CN105169149A - Traditional Chinese medicine composition for treating pyrophlegm stasis accumulation type thyroid cancer, preparation method and application - Google Patents
Traditional Chinese medicine composition for treating pyrophlegm stasis accumulation type thyroid cancer, preparation method and application Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating the pyrophlegm stasis accumulation type thyroid cancer, a preparation method and application. The traditional Chinese medicine composition is prepared from, by weight, 6-12 parts of dioscorea bulbifera L, 6-12 parts of rhizoma Sparganii, 6-12 parts of radix glycyrrhizae, 10-20 parts of dried radix rehmanniae, 10-20 parts of radix scrophulariae, 4-9 parts of bupleurum, 6-12 parts of fried tangerine seed, 10-20 parts of snake gourd fruit, 10-20 parts of lonicera japonica, 10-20 parts of common selfheal fruit-spike, 10-20 parts of pericarpium citri reticulatae, 10-20 parts of seaweed, 10-20 parts of kelp and 20-40 parts of oyster. According to the formula, on the basis of comprehensive analysis on the thyroid cancer, according to the dialectical therapy principle, through the latest technology and means, through the combination of 30 years of clinical experience of hospitals and through trials and errors, the traditional Chinese medicine composition is developed, has a good curative effect on the later-period thyroid cancer, especially the undifferentiation type thyroid cancer, is mainly suitable for the pyrophlegm stasis accumulation type thyroid cancer, and has curative effects on eliminating sputum and softening hard mass, and promoting blood circulation to remove blood stasis.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of treat phlegm-fire stasis type thyroid carcinoma Chinese medicine composition and preparation method, application.
Background technology
Thyroid carcinoma is the modal malignant tumor of incidence, from pathology, mainly be divided into four types: papillary carcinoma, follicular carcinoma, medullary carcinoma and undifferentiated carcinoma, operation is its topmost therapeutic modality, can not the person of elimination for late tumor operation, papillary carcinoma and follicular carcinoma can adopt radionuclide therapy as differentiated thyroid carcinoma, medullary carcinoma and undifferentiated carcinoma are then of no curative effect the expectant treatment method of affirmative, especially undifferentiated carcinoma progress is fast, grade malignancy is high, and Most patients is dead in 6-10 month.
Thyroid carcinoma belongs to the traditional Chinese medical science " stony goiter " category, and the main pathogenesis of primary disease is stagnation of QI due to depression of the liver, dysfunction of the spleen in transportation, raw in phlegm-damp, stagnation of QI-blood, and phlegm-damp condensation throat, with the passing of time causes blood-vessel obstructive, with gas, expectorant, stasis of blood three combined into trouble.The disease of goiter, though have, the stagnation of QI, expectorant are solidifying, blood stasis is not, the intrinsic factor of its morbidity, is namely that human righteousness is weak.The generation of disease and human righteousness's close relation, due to positive QI-insufficiency, so that pathogenic factor is taken advantage of a weak point, knot gathers in meridians, internal organs, causes the pathological changes such as the stagnation of QI, expectorant are solidifying, blood stasis, leads to the disease of goiter.Its etiology and pathogenesis mainly contains three aspects: 1, the stagnation of QI: gas is the main manifestations of human body physiological function, is the important substance basis maintaining human life activity.As crossed because of diet partially or depressed, depressed emotion of being worried, making fate row not normal, functional disorder, forming the pathological phenomenon of the stagnation of QI, the stagnation of QI.Long-term depression and stagnation of QI, is polymerized to shape for a long time, causes lump to occur, and tying in throat is goiter due to disorder of QI.2, blood stasis: qi being the governor of blood, the stagnation of QI is hematogenous blockage then, stagnate with the passing of time, Ze Cheng Disorder tie lump, in cervical region be then stony goiter.3, expectorant coagulates: exopathogen is invaded and harassed, or feelings will internal injury, and has a delicate constitution, and multipotency makes mechanism of qi block, and body fluid gathers as expectorant.It is toxic goiter that expectorant is condensed in larynx both sides.
In a word, the origin cause of formation of thyroid carcinoma is that many factors causes, and other still have wet poly-, deficiency of the liver and kindey, heart-fire to recklessly act etc., and main be positive QI-insufficiency, exopathogen invade, so that the stagnation of QI, blood stasis, expectorant coagulate mutually cementing, form goiter.
Thyroid carcinoma mostly is phlegm-fire stasis type late period, and main manifestations is: cervical region wart arsine, partially hard in matter, in circle or oval, border is still clear, or matter is hard as stone, be difficult to pass, can be upper and lower with swallowing, with pharyngeal discomfort, or see the lower scrofula of chin, throat blocks, and swallows not smooth, very then hoarseness, suffocated breathing uncomfortable in chest, shape is thin thin, face is dim not damp, and thin fur or few, colour of the tongue purple is dim.Or having menoxenia, yellow, greasy and thin fur, body of the tongue is partially dark, stringy and rolling pulse.
For various reasons, the expectant treatment of thyroid carcinoma lacks effective method, especially undifferentiated carcinoma, and simple operative treatment is unsatisfactory, in the urgent need to finding novel Therapeutic Method.To the treatment of goiter, Chinese dynasties also have accumulated and compares rich experience, as Jin Dynasty ZHANG Cong-zheng proposes to prevent and treat goiter with Thallus Laminariae (Thallus Eckloniae), Sargassum, Thallus Laminariae (Thallus Eckloniae) in " Confucian's Duties to Their Parents ", Li Shizhen (1518-1593 A.D.) is loaded with by Rhizoma Dioscoreae Bulbiferae wine treatment goiter etc. in Compendium of Material Medica, so far these a few herbs are still the key medicine for the treatment of thyroid tumor, adopt and do not wane.More and more evidence shows, Chinese medicine can improve patient's immunity, fast track rehabilitation, prevents and delay recurrence and the transfer of thyroid carcinoma.
Thyroid carcinoma traditional Chinese medical herbal treatment relates generally to liver, spleen, dialectically should first distinguish excess and weakness of pathogen and vital QI relation, distinguishes the stagnation of QI and expectorant is tied, and distinguishes stagnation of liver-QI and insufficiency of the spleen.Disease in early days based on the domination of pathogen, namely with phlegm-damp cohesion, stagnation of QI due to depression of the liver for principal contradiction, now treatment should focus on liver-smoothing, qi-regulating, invigorating spleen to remove dampness reduces phlegm, the wart that disappears eliminating stagnation, to disappear, to attack; Middle and advanced stage thyroid cancer patients is due to the long-term consumption of disease, and healthy energy virtual loss is double accompanies the domination of pathogen, wherein based on healthy energy virtual loss, treatment should be noted the principle of strengthening vital QI to eliminate pathogenic factors, invigorating the spleen and benefiting QI, reinforcement and elimination in combination.Because of the stagnation of QI, expectorant coagulate, to stop up knot throat be the basic pathology that stony goiter is formed to blood stasis three, and some patients also shows as mental disorder pent-up, the strongly fragrant and pathological change of fire-transformation.Therefore primary disease is in the majority with excess syndrome person in early days, but sick then wasting QI-blood for a long time, cloudy essence is impaired, and often Sthenia is transforming into asthenia for disease, is wherein common with the deficiency of YIN, the deficiency of vital energy especially, so that becomes the syndrome of intermingled deficiency and excess that provide for the real in the unreal and for the unreal in the real.Be resolving phlegm and softening hard masses to the main rule for the treatment of of phlegm-fire stasis type thyroid carcinoma, blood circulation promoting and dispersing pathogen accumulation.
Summary of the invention
For the deficiencies in the prior art, the problem to be solved in the present invention is to provide a kind of Chinese medicine formula for the treatment of thyroid carcinoma, formula is carrying out on comprehensive analysis foundation to thyroid carcinoma, principle is treated according to dialectical, utilize state-of-the-art technology and means, in conjunction with hospital's more than 30 years clinical experience, develop through repetition test, to patients with late-stage thyroid carcinoma, especially undifferentiated type thyroid carcinoma has good therapeutic effect.Mainly be applicable to phlegm-fire stasis type thyroid carcinoma, the rule for the treatment of is resolving phlegm and softening hard masses, blood circulation promoting and dispersing pathogen accumulation.
For achieving the above object, the present invention adopts following technical scheme:
Treat a Chinese medicine composition for phlegm-fire stasis type thyroid carcinoma, be made up of the crude drug of following parts by weight:
Rhizoma Dioscoreae Bulbiferae 6-12 part, Rhizoma Sparganii 6-12 part, Radix Glycyrrhizae 6-12 part, Radix Rehmanniae 10-20 part, Radix Scrophulariae 10-20 part, Radix Bupleuri 4-9 part, stir-fry Fructus Citri tangerinae core 6-12 part, Fructus Trichosanthis 10-20 part, Flos Lonicerae 10-20 part, Spica Prunellae 10-20 part, Pericarpium Citri Reticulatae 10-20 part, Sargassum 10-20 part, Thallus Laminariae (Thallus Eckloniae) 10-20 part, Concha Ostreae 20-40 part.
Preferably, the Chinese medicine composition of above-described treatment phlegm-fire stasis type thyroid carcinoma, be made up of the crude drug of following parts by weight:
Rhizoma Dioscoreae Bulbiferae 7-11 part, Rhizoma Sparganii 7-11 part, Radix Glycyrrhizae 7-11 part, Radix Rehmanniae 12-18 part, Radix Scrophulariae 12-18 part, Radix Bupleuri 5-8 part, stir-fry Fructus Citri tangerinae core 7-11 part, Fructus Trichosanthis 12-18 part, Flos Lonicerae 12-18 part, Spica Prunellae 12-18 part, Pericarpium Citri Reticulatae 12-18 part, Sargassum 12-18 part, Thallus Laminariae (Thallus Eckloniae) 12-18 part, Concha Ostreae 25-35 part.
Preferably, the Chinese medicine composition of above-described treatment phlegm-fire stasis type thyroid carcinoma, be made up of the crude drug of following parts by weight:
Rhizoma Dioscoreae Bulbiferae 8 parts, Rhizoma Sparganii 8 parts, 8 parts, Radix Glycyrrhizae, 16 parts, the Radix Rehmanniae, Radix Scrophulariae 16 parts, Radix Bupleuri 6 parts, stir-fry Fructus Citri tangerinae core 8 parts, Fructus Trichosanthis 16 parts, Flos Lonicerae 16 parts, Spica Prunellae 16 Pericarpium Citri Reticulatae 16 parts, Sargassum 16 parts, Thallus Laminariae (Thallus Eckloniae) 16 parts, Concha Ostreae 30 parts.
The Chinese medicine composition for the treatment of phlegm-fire stasis type thyroid carcinoma of the present invention, is prepared into oral liquid, granule, capsule, drop pill, decoction or tablet etc. by the extract of each crude drug and pharmaceutically acceptable carrier and facilitates the clinical pharmaceutical dosage form taken.
When the extract of each raw material of the Chinese medicine composition for the treatment of phlegm-fire stasis type thyroid carcinoma provided by the invention is made oral liquid, the extract adding distil water of each raw material is dissolved, filter, add syrup, adjust ph, make oral liquid.
When the extract of each raw material of the Chinese medicine composition for the treatment of phlegm-fire stasis type thyroid carcinoma provided by the invention is made tablet, the extract of each raw material and lactose or corn starch, add magnesium stearate lubricant when needing, mix homogeneously, granulate, then tablet made by tabletting.
The extract of each raw material and carrier lactose or corn starch mix homogeneously when the extract of each raw material of the Chinese medicine composition for the treatment of phlegm-fire stasis type thyroid carcinoma provided by the invention makes capsule, granulate, then encapsulatedly makes capsule.
When the extract of each raw material of the Chinese medicine composition for the treatment of phlegm-fire stasis type thyroid carcinoma provided by the invention makes granule, the extract of each raw material and diluent lactose or corn starch mix homogeneously, granulate, dry, make granule.
The Chinese medicine composition for the treatment of phlegm-fire stasis type thyroid carcinoma of the present invention is preparing the application prevented and treated in thyroid carcinoma medicine.
The preparation method of the Chinese medicine composition for the treatment of phlegm-fire stasis type thyroid carcinoma provided by the invention: the mixing of various crude drug is placed in extractor, extracts with water or hydrophilic solvent, concentrated extracting solution and get final product.
Described hydrophilic solvent is preferably selected from ethanol, methanol, acetone, butanediol or propylene glycol etc.
Described extraction can be the methods such as decoction, reflux, extract, dipping, percolation.
Specifically comprise the steps:
Get each taste crude drug by the parts by weight described in above-mentioned Chinese medicine composition, add crude drug 8-16 times water gaging, decoct and extract 2-3 time, each 30-60 minute, obtains decocting liquid, and being concentrated into decocting liquid proportion is 1.15-1.20---and when 40 DEG C, leave standstill 1-2 hour, obtain decoction.
Further, each crude drug is taken with the weight proportion described in above-mentioned Chinese medicine composition, be distributed in clean sandbag, then insert in retort and soak 1-1.5 hour, decocted 3 times respectively with 1 hour, 40 minutes, 30 minutes, merge 3 decocting liquids, filtering with 40-60 mesh sieve, is 0.1Kg/cm in steam pressure
2condition under, then concentrate decocting liquid with membrane evaporator, when being 1.15-1.20 (40 DEG C) to decocting liquid proportion, stop concentrated, leave standstill after 1-2 hour, by concentrated supernatant soft-packaged machine with therapeutic dose subpackage, conventional sterilant, label, packaging, namely makes decoction.
Containing a certain amount of linalool, epoxylinalol in Flos Lonicerae of the present invention, after mixing with the medical material such as Rhizoma Dioscoreae Bulbiferae, Rhizoma Sparganii, decocting in process for a long time, be subject to high temperature, loss of volatile oil is comparatively large, therefore, in the present invention, preferred decocting time is 15 minutes, and decocting number of times is 2 times.
The present invention also provides a kind of Chinese medicine preparation be made up of above-mentioned Chinese medicine composition and excipient, and this Chinese medicine preparation can be solution, ointment, Emulsion or cream kind.Such as, in the concentrated solution of gained, add a certain amount of ethanol or polyhydric alcohol and appropriate antiseptic, can be made into the solution containing crude drug amount 50-500mg/ml.
The Chinese medicine composition for the treatment of phlegm-fire stasis type thyroid carcinoma provided by the invention, in side, Rhizoma Dioscoreae Bulbiferae, Sargassum, Thallus Laminariae (Thallus Eckloniae) dissipating phlegm and resolving masses softening the hard mass are monarch drug altogether, and Concha Ostreae, Spica Prunellae hard masses softening and resolving, removing heat-phlegm mutual reinforcement between are for using, Fructus Trichosanthis, Radix Platycodonis removing heat-phlegm, eliminating stagnation, Rhizoma Sparganii removing blood stasis disappears abdominal mass, is ministerial drug.Help with Radix Bupleuri, Pericarpium Citri Reticulatae promoting QI circulation for relieving depression, regulating functional activities of qi.The Radix Rehmanniae, Radix Scrophulariae have the merit of eliminating fire and detoxication, hard masses softening and resolving, are equipped with Flos Lonicerae eliminating carbuncle and dispel swollen.Radix Glycyrrhizae, Gan Wen, coordinating the actions of various ingredients in a prescription.
Rhizoma Dioscoreae Bulbiferae returns lung, Liver Channel, nature and flavor: bitter, pungent, salty, cool in nature, slightly poisonous.Obvious toxic-side effects is had to liver containing toxicity saponin, terpenoid.Chemical composition: containing diobulbine A, Saponin, tannin and starch.Partial desiccation tuber is containing sucrose 22.5%, reducing sugar 0.69%, starch 2.5%, Saponin, tannin.Also containing diosbulbin B, C and diosgenin.There is removing toxic substances and promoting subsidence of swelling, dissipating phlegm and resolving masses, effect of cooling blood for hemostasis.For thyromegaly, tuberculous lymphadenitis, laryngopharynx swelling and pain, spits blood, spitting of blood, pertussis, cancerous protuberance; Furuncle is controlled in external.To various types of goiter, all there is certain effect.Rhizoma Dioscoreae Bulbiferae wine like partly replacing surgical removal to thyroid tumor, for thyroid carcinoma, coordinates operative treatment, can improve curative effect.Eliminating stagnation disappears wart; Heat-clearing and toxic substances removing; Cooling blood for hemostasis.Main goiter, sore throat, carbuncle sore tumefacting virus, venom, tumor, haematemesis, epistaxis, spitting of blood, pertussis, lung-heat cough with asthma.
Rhizoma Sparganii returns liver, spleen channel, and property is pungent, bitter, flat, has removing blood stasis circulation of qi promoting, effect of removing food stagnancy pain relieving, for lump in the abdomen mass in the abdomen, and dysmenorrhea, blood stasis amenorrhea, obstruction of qi in the chest and cardialgia, food stagnation distending pain.Chemical analysis is phenethanol, hydroquinone, hexadecylic acid; also have totally 21 compositions such as dehydrocostuslactone, 3,4-dihydro-8-hydroxy-3-methyl-1H2-benzopyran-4-ones, 1-hydroxyl-2-acetyl group-4-methylbenzene, β elemene, 2-furan alcohol, 2-acetyl pyrrole.Again containing multiple organic acid: the acid of succinic acid, Rhizoma Sparganii, 9-11-octadecadienoic acid, 9-12-octadecadienoic acid, 10-nonadecenoic acid, 11-eicosenoic acid, benzoic acid, 3-benzene-2-acrylic acid, Azelaic Acid, decanedioic acid and the fatty acid containing C8-C10, C12, C14-C20.Also containing formoononetin, stigmasterol, cupreol, daucosterol etc.
Radix Glycyrrhizae property is sweet, flat, enters spleen, stomach, lung meridian.Have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic and antitumaous effect, in the traditional Chinese medical science, the removing toxic substances of Radix Glycyrrhizae energy invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, emergency, hundred medicines that are in harmonious proportion.Modern medicine study shows, Radix Glycyrrhizae has antiviral, antiinflammatory, effect of protecting the liver, can be used for treating insufficiency of the spleen, cough and asthma, laryngopharynx swelling and pain, carbuncle pyogenic infections from tumour or sore etc.
The Radix Rehmanniae is sweet, cold.GUIXIN, liver, kidney channel.Main containing B-sitosterol and mannitol, and a small amount of stigmasterol, micro-campesterol, also containing rehmanin, alkaloid, fatty acid, catalpol, glucose and retinoid material; Root is again containing stachyose, arginine and r-Gamma Amino Butyric Acid.Have heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, removing heat from blood, anastalsis.
Sweet, salty, the micro-hardship of Radix Scrophulariae property, cold.Enter lung, stomach, kidney channel.There is effect of clearing away heat and cooling blood, eliminating fire and detoxication, hard masses softening and resolving.Normal cooperation Bulbus Fritillariae Uninbracteatae, the same use of Concha Ostreae, name says Xiao Lei Wan.Or suitably add Spica Prunellae, Thallus Laminariae (Thallus Eckloniae), the equivalent use of Sargassum.
Radix Bupleuri nature and flavor are bitter, be slightly cold, and return liver, gallbladder meridian.There is reconciling superficies and interior, effect of soothing the liver yang invigorating.Radix Bupleuri root is containing volatile oil, bupleurumol, oleic acid, linolenic acid, Palmic acid, stearic acid, carnaubic acid, glucose and Saponin etc.Markets Drug is had, saikoside unit F, E, G, longispinogenin in Saponin.Separately have report, separate saikoside in root and seed, this is the general name of multiple glycoside.In addition, hitodesterol, Δ 7-stigmastenol, Δ 22-stigmastenol, stigmasterol, adonite, Radix Angelicae Dahuricae element is contained in root.Stem, leaf are containing globulariacitrin.Fruit oil-containing 11.2%, wherein has petroselinic acid, petroselidic acid and sub-sleeve acid.Saikosaponin d gavage or lumbar injection have Tumor suppression growth to mice ehrlich carcinoma, and obviously can extend the life span of animal.Have the tumor necrosis factor of anticarcinogenic effect with the purebred white rabbit preparation of New Zealand with Radix Bupleuri, using hepatoma carcinoma cell as target cell, result makes cancer cellular necrosis, cracking.
Fry Fructus Citri tangerinae nuclearity bitter, flat, nontoxic.Enter liver, kidney channel.Regulate the flow of vital energy, eliminating stagnation, pain relieving.
Fructus Trichosanthis sweet in the mouth, cold in nature.Have lung moistening to eliminate the phlegm, the effect of promoting the circulation of QI the chest stuffiness relieving.Containing Saponin, organic acid and salt thereof, resin, fatty oil and pigment.The fatty oil amount of imitating is 26%, and wherein satisfied fatty acid accounts for 30%, and unsaturated fatty acid accounts for 66.5%, based on trichosanic acid.In addition, still containing pomegranate acid in seed oil, may be the special sheet composition in snake gourd seed oil.Also containing 4 △ 5-terpenoid in oil, 6 △ 7-terpenoid, are accredited as campesterol, 7,24-gallbladder steroid diene alcohol, 7,25-gallbladder steroid diene alcohol, 7,22,25-cholestatriene alcohol.And assign to the complete alcohol of bean steroid.1:5 Fructus Trichosanthis decoct can kill mouse ascites cancerous cell in vitro.The external anticancer effect of Pericarpium Trichosanthis is better than Semen Trichosanthis, and the strongest with 60% ethanol extraction effect.The noncrystal powder of off-white color obtained in the ether leachate of Pericarpium Trichosanthis also has anti-cancer effect in vitro, and animal experiment shows, Fructus Trichosanthis has certain inhibitory action to sarcoma.
Flos Lonicerae is sweet, micro-hardship, and delicate fragrance is pungent, cold.Return lung, stomach, the heart, large intestine channel.Containing chlorogenic acid, isochlorogenic acid, Ginnol, cupreol, stigmasterol, cupreol-D-Glucose glycoside, stigmasterol-D-Glucose glycoside, also containing volatile oil, its composition has linalool, left-handed-along trimethyl-2-vinyl-5-dihydroxy-tetrahydro pyrans, ethyl palmitate, 1, 1-di-thiacyclohexane, methyl linoleate, 3-methyl-2-(pentenyl)-2-cyclopentene-1-one, trans-anti-farnesol, ethyl linolenate, β-Bi clear casket oil alkene, cis-3-is alkene-1-alcohol, alpha-terpineol, Geraniol, benzyl benzoate, 2-methyl-butanol, benzyl alcohol, phenethanol, cis-linalool oxide, eugenol and carvacrol etc. tens of kinds.There are resisting pathogenic microbes effect, antiinflammatory and refrigeration function, the effect of booster immunization function, central excitation effect, blood fat reducing, antiendotoxin etc.Honeysuckle flower water and steeping in wine liquid have obvious lethal effect to tentative tumor cell.
Spica Prunellae is cold in nature, sweet in the mouth, pungent, micro-hardship.For the key medicine of clearing away liver-fire, Disperse hepatic depression, for scrofula, goiter, often join Concha Ostreae, Bulbus Fritillariae Thunbergii.Containing acidity many grain Polysaccharides from Prunella vulgaris L of tool anti human immune deficiency virus (HIV), it is also the Saponin of glycoside unit containing oleanolic acid, ursolic acid, oleanolic acid, globulariacitrin, hyperin, caffeic acid, vitamin C, D, D carotene, tannin and volatile oil.
Pericarpium Citri Reticulatae is warm in nature, acrid in the mouth, bitter in the mouth.Enter spleen channel, stomach warp, lung meridian.Regulating qi-flowing for strengthening spleen, in tune, dampness, reduces phlegm.Cure mainly distension and fullness in the abdomen or pain, the dyspepsia of stagnation of QI in spleen and stomach.Containing volatile oil, in oil, main component is D-limonene, beta-myrcene α-and nopinene etc., another containing the nor-dihydro Nobiletin of flavones ingredient hesperidin, neohesperidin, naringenin, dihydro Nobiletin and 5-.
Sargassum property is bitter, salty, cold.Return lung, spleen, kidney, liver stomach warp.There is effect of softening the hard mass, expectorant, diuretic, detumescent, cure mainly scrofula, goiter etc.Seaweed extracted liquor proteoglycan can resist various virus, comprising HIV (human immunodeficiency virus) and carcinogenic RNA viruses, has anticancer antivirus action.
Thallus Laminariae (Thallus Eckloniae) is salty, cold, returns liver, stomach, kidney channel.There is hard masses softening and resolving, expectorant, the function of diuretic, for goiter, scrofula.Containing algin element, mannitol, galactan, laminine, Thallus Laminariae (Thallus Eckloniae) polysaccharide, glutamic acid, aspartic acid, proline, vitamin B1, vitamin C, Citrin and iodine, potassium etc.
Concha Ostreae property is salty, is slightly cold.Return liver, gallbladder, kidney channel.Suppressing the hyperactive liver to relieve the wind syndrome and yin-nourishing drug, hard masses softening and resolving.Calcium carbonate containing 80% ~ 95%, calcium phosphate and calcium sulfate, and containing magnesium, aluminum, silicon and ferrum oxide etc.Concha Ostreae is containing glycogen, and taurine, 10 kinds of essential amino acids, glutathion, vitamin A, B1, B2, D, inanimate matter is as copper, zinc, manganese, barium, phosphorus and calcium etc., and wherein contained leucine, arginine, citrulline content are the abundantest.
The each flavour of a drug proportioning of full side, has the pathogenesis demonstrate,proved for thyroid carcinoma " phlegm-fire stasis ", reinforcement and elimination in combination, plays the merit of " resolving phlegm and softening hard masses, blood circulation promoting and dispersing pathogen accumulation " altogether, clinical evident in efficacy to thyroid carcinoma.
Beneficial effect: compared to the prior art the Chinese medicine composition for the treatment of phlegm-fire stasis type thyroid carcinoma provided by the invention has the following advantages:
1, the medicine for the treatment of thyroid carcinoma of the present invention particularly above-mentioned Chinese medicine decoction, application modern crafts process, not only inhibition tumor cell growth diffusion, and anti-gene mutation, can also improve body's immunity, thus mitigation symptoms, extend patient vitals.
2, the medicine for the treatment of thyroid carcinoma of the present invention is for patients with late-stage thyroid carcinoma, especially the pathological characteristic of undifferentiated type thyroid carcinoma, the cost-effective therapeutic scheme of custom-designed one is treated in conjunction with differential diagnosis in tcm, can significantly improve symptom, reduce tumor and even make tumor disappearance, extend patient's life-span.
3, the present invention is according to Chinese medical theory, the theory of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is adopted to carry out Chinese prescription screening, the Chinese medicine composition proportioning of the treatment phlegm-fire stasis type thyroid carcinoma provided is scientific and reasonable, experimental result shows, Chinese medicine composition provided by the invention has the effect well suppressing thyroid carcinoma cell growth and can promote apoptosis of tumor cells; There is raising immunity function, can obviously reduce tumor patient misery, extend life cycle, improve the effect of life in patients, and show through long-term experiment research, the Chinese medicine composition safety for the treatment of phlegm-fire stasis type thyroid carcinoma provided by the invention is high, and toxic and side effects is low.
4, the extract of the Chinese medicine composition for the treatment of phlegm-fire stasis type thyroid carcinoma provided by the invention, can facilitate and pharmaceutical carriers is prepared into multiple dosage form, taking convenience clinically.
Detailed description of the invention
The present invention is illustrated further below in conjunction with specific embodiment, these embodiments should be understood only be not used in for illustration of the present invention and limit the scope of the invention, after having read the present invention, the amendment of those skilled in the art to the various equivalent form of value of the present invention has all fallen within the application's claims limited range.
Embodiment 1
Each crude drug (unit in kilogram) is taken by following weight proportion
Preparation method is as follows: take each crude drug with the weight proportion described in prescription respectively, be distributed in clean sandbag, then insert in retort and soak 1-1.5 hour, decocted 3 times respectively with 1 hour, 40 minutes, 30 minutes, merge 3 decocting liquids, filtering with 40-60 mesh sieve, is 0.1Kg/cm in steam pressure
2condition under, then concentrate decocting liquid with membrane evaporator, when being 1.15-1.20 (40 DEG C) to decocting liquid proportion, stop concentrated, leave standstill after 1-2 hour, by concentrated supernatant soft-packaged machine with therapeutic dose subpackage, conventional sterilant, label, packaging, namely makes decoction.
Instructions of taking: every day 1 dose, serve on 5 days, 5 doses weekly, having a rest 2 days, 4 weeks is a course for the treatment of.
Embodiment 2
Each crude drug (unit in kilogram) is taken by following weight proportion
Preparation method is as follows: take each crude drug with the weight proportion described in prescription respectively, be distributed in clean sandbag, then insert in retort and soak 1-1.5 hour, decocted 3 times respectively with 1 hour, 40 minutes, 30 minutes, merge 3 decocting liquids, filtering with 40-60 mesh sieve, is 0.1Kg/cm in steam pressure
2condition under, then concentrate decocting liquid with membrane evaporator, when being 1.15-1.20 (40 DEG C) to decocting liquid proportion, stop concentrated, leave standstill after 1-2 hour, by concentrated supernatant soft-packaged machine with therapeutic dose subpackage, conventional sterilant, label, packaging, namely makes decoction.
Instructions of taking: every day 1 dose, serve on 5 days, 5 doses weekly, having a rest 2 days, 4 weeks is a course for the treatment of.
Embodiment 3
Each crude drug (unit in kilogram) is taken by following weight proportion
Preparation method is as follows: take each crude drug with the weight proportion described in prescription respectively, be distributed in clean sandbag, then insert in retort and soak 1-1.5 hour, decocted 3 times respectively with 1 hour, 40 minutes, 30 minutes, merge 3 decocting liquids, filtering with 40-60 mesh sieve, is 0.1Kg/cm in steam pressure
2condition under, then concentrate decocting liquid with membrane evaporator, when being 1.15-1.20 (40 DEG C) to decocting liquid proportion, stop concentrated, leave standstill after 1-2 hour, by concentrated supernatant soft-packaged machine with therapeutic dose subpackage, conventional sterilant, label, packaging, namely makes decoction.
Instructions of taking: every day 1 dose, serve on 5 days, 5 doses weekly, having a rest 2 days, 4 weeks is a course for the treatment of.
Embodiment 4
Each crude drug (unit in kilogram) is taken by following weight proportion
Preparation method is as follows: take each crude drug with the weight proportion described in prescription respectively, be distributed in clean sandbag, then insert in retort and soak 1-1.5 hour, decocted 3 times respectively with 1 hour, 40 minutes, 30 minutes, merge 3 decocting liquids, filtering with 40-60 mesh sieve, is 0.1Kg/cm in steam pressure
2condition under, then concentrate decocting liquid with membrane evaporator, when being 1.15-1.20 (40 DEG C) to decocting liquid proportion, stop concentrated, leave standstill after 1-2 hour, by concentrated supernatant soft-packaged machine with therapeutic dose subpackage, conventional sterilant, label, packaging, namely makes decoction.
Instructions of taking: every day 1 dose, serve on 5 days, 5 doses weekly, having a rest 2 days, 4 weeks is a course for the treatment of.
Embodiment 5
Each crude drug (unit in kilogram) is taken by following weight proportion
Preparation method is as follows: take each crude drug with the weight proportion described in prescription respectively, be distributed in clean sandbag, then insert in retort and soak 1-1.5 hour, decocted 3 times respectively with 1 hour, 40 minutes, 30 minutes, merge 3 decocting liquids, filtering with 40-60 mesh sieve, is 0.1Kg/cm in steam pressure
2condition under, then concentrate decocting liquid with membrane evaporator, when being 1.15-1.20 (40 DEG C) to decocting liquid proportion, stop concentrated, leave standstill after 1-2 hour, by concentrated supernatant soft-packaged machine with therapeutic dose subpackage, conventional sterilant, label, packaging, namely makes decoction.
Instructions of taking: every day 1 dose, serve on 5 days, 5 doses weekly, having a rest 2 days, 4 weeks is a course for the treatment of.
Embodiment 6
Be, in preparation process with the difference of embodiment 1: Concha Ostreae is decocted first.Get Concha Ostreae, add Concha Ostreae 8 times of water yields, decoct after 15 minutes, again other crude drug medicine is put into simultaneously, add medical material 8 times of water yields, decocted 3 times respectively with 1 hour, 40 minutes, 30 minutes, merge 3 decocting liquids, filter with 40-60 mesh sieve, take steam pressure as 0.1Kg/cm2 condition, concentrate decocting liquid with membrane evaporator again, when being 1.15-1.20 (40 DEG C) to decocting liquid proportion, stop concentrated, leave standstill after 1-2 hour, by concentrated supernatant soft-packaged machine with therapeutic dose subpackage, conventional sterilant, labels, packaging, namely makes decoction.
Embodiment 7
Be with the difference of embodiment 1, preparation method is:
(1) get Concha Ostreae 24 parts, add medical material 15 times of water gagings, supersound extraction 3 times, each 3 hours, obtain Aqueous extracts, concentrated, n-butanol extraction, obtains butanol extraction liquid, upper macroporous resin column, rinse with water, then be 20 ~ 50% ethanol elutions by concentration, obtain alcohol eluen, vacuum drying, obtain Concha Ostreae extract, for subsequent use;
(2) get Rhizoma Dioscoreae Bulbiferae 7 parts, Rhizoma Sparganii 7 parts, 7 parts, Radix Glycyrrhizae, 10 parts, the Radix Rehmanniae, Radix Scrophulariae 10 parts, Radix Bupleuri 4 parts, fry Fructus Citri tangerinae core 7 parts, Fructus Trichosanthis 10 parts, Flos Lonicerae 10 parts, Spica Prunellae 10 parts, Pericarpium Citri Reticulatae 10 parts, Sargassum 10 parts, Thallus Laminariae (Thallus Eckloniae) 10 parts, add medical material 10 times amount concentration 60% alcohol heating reflux and extract three times, each 2 hours, merge extractive liquid, filter, filtrate recycling ethanol, concentrated, vacuum drying obtains extract, for subsequent use;
(3) extract that obtains of the Radix Codonopsis extract that obtains of combining step (1) and step (2), then add lactose, corn starch mix homogeneously, adds magnesium stearate lubricant, mix homogeneously, granulate, and then tablet made by tabletting.
Embodiment 8
In the medicine book in modern times, the record about Concha Ostreae mostly is life suppressing the hyperactive liver and subsiding YANG, forges with convergence astringent or styptic treatment for spontaneous sweating.Containing abundant ferrum, manganese, copper, zinc in Concha Ostreae, and returning of the content of trace element and Concha Ostreae has substantial connection through, effect.When adopting the decocting method process Concha Ostreae described in the embodiment of the present invention 1, experiment shows: Concha Ostreae is after forging, and the fried amount of zinc, copper increases, and especially after forging vinegar extraction, the fried amount of manganese, ferrum significantly increases.
Embodiment 9
Be with the difference of embodiment 1, in preparation process, decocting time is 15min, and decocting number of times is 2 times.
Embodiment 10
Clinical observation experiment
1.1 clinical data
1.1 physical data
Choose Shandong Tumor Hospital's outpatient service or ward and be diagnosed as late period and undifferentiated type thyroid cancer patients 298 example, male 157 example, women 141 example, 51.3 ± 6.00 years old mean age, the course of disease 4.32 ± 1.09 years;
1.2 Therapeutic Method
Taking the Traditional Chinese medicine compound composition that the embodiment of the present invention 1 prepares, usage: every day 1 dose, serve on 5 days, 5 doses weekly, have a rest 2 days, 4 weeks is a course for the treatment of.
1.3 therapeutic evaluation
Recovery from illness (complete incidence graph): body strengthens, antisecosis, transference cure, CT shows tumor and disappears completely after treatment, and the time is no less than 4 weeks.
Effectively (partial rcsponse): body strengthens, and muscle power comparatively treats front improvement, and symptom alleviates, CT shows tumor and reduce more than 50% after treatment, and the persistent period is no less than 4 weeks, occurs without new focus simultaneously.
Tumor stabilisation or unchanged: patient's muscle power comparatively before makes moderate progress, symptom without significant change, CT show tumor through treatment after reduce be no more than 50% or increase be no more than 25%.
Tumour progression: patient's physically-draining, exacerbation of symptoms, CT shows tumor and comparatively treats front increase or occur new focus.
2 therapeutic outcomes
Late period and undifferentiated type thyroid carcinoma 298 example, (5 doses weekly, serve on 5 days, has a rest 2 days to take Chinese medicine preparation of the present invention, within 4 weeks, be a course for the treatment of), applied for 3 courses for the treatment of, result shows: recovery from illness 9 example, effective 211 examples, stable disease 31 example, progress 46 example, total effective rate 84.6%.
The medicine particularly above-mentioned Chinese medicine decoction for the treatment of thyroid carcinoma of the present invention, application modern crafts process, not only inhibition tumor cell growth diffusion, and anti-gene mutation, can also improve body's immunity, thus mitigation symptoms, extend patient vitals.
Outcome measure
3 model cases
The outstanding effect of compound preparation in clinical treatment applying treatment thyroid carcinoma of the present invention is further illustrated below with model case.
Case 1 Wang, female, 45 years old, Heze City, Shandong Province people, finds that throat enclosed mass is gone to see a doctor with hoarseness for 1 month, is diagnosed as thyroid carcinoma and walks abreast operative treatment, because tumor invading carotid arteries and vitals fail thoroughly to excise, post operative diagnosis is anaplastic thyroid carcinoma.Take treatment by Chinese herbs of the present invention, pronounce comparatively and improve after 1 course for the treatment of, 3 CT check display course for the treatment of tumor disappearance, follow up a case by regular visits to half a year without recurrence.
Case 2 Lee, female, 65 years old, people from Dezhou, Shandong, because " Diagnosis of Cervical Masses 20 years; hoarseness 2 months " went to see a doctor, be diagnosed as thyroid malignancy, give excision, in art, find tumors invading and trachea and larynx, fail to excise completely for retaining larynx trachea function, Pathological diagnoses is anaplastic thyroid carcinoma.Take 3 courses for the treatment of of Chinese medicine preparation of the present invention, CT checks before tumor is comparatively taken medicine and reduces 80%, follows up a case by regular visits to 1 year tumor and has no continued growth.
In a word, the medicine for the treatment of thyroid carcinoma of the present invention is for patients with late-stage thyroid carcinoma, especially the pathological characteristic of undifferentiated type thyroid carcinoma, the cost-effective therapeutic scheme of custom-designed one is treated in conjunction with differential diagnosis in tcm, can significantly improve symptom, reduce tumor and even make tumor disappearance, extend patient's life-span.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (9)
1. treat a Chinese medicine composition for phlegm-fire stasis type thyroid carcinoma, it is characterized in that, be made up of the crude drug of following parts by weight:
Rhizoma Dioscoreae Bulbiferae 6-12 part, Rhizoma Sparganii 6-12 part, Radix Glycyrrhizae 6-12 part, Radix Rehmanniae 10-20 part, Radix Scrophulariae 10-20 part, Radix Bupleuri 4-9 part, stir-fry Fructus Citri tangerinae core 6-12 part, Fructus Trichosanthis 10-20 part, Flos Lonicerae 10-20 part, Spica Prunellae 10-20 part, Pericarpium Citri Reticulatae 10-20 part, Sargassum 10-20 part, Thallus Laminariae (Thallus Eckloniae) 10-20 part, Concha Ostreae 20-40 part.
2. the Chinese medicine composition for the treatment of phlegm-fire stasis type thyroid carcinoma according to claim 1, is characterized in that, be made up of the crude drug of following parts by weight:
Rhizoma Dioscoreae Bulbiferae 7-11 part, Rhizoma Sparganii 7-11 part, Radix Glycyrrhizae 7-11 part, Radix Rehmanniae 12-18 part, Radix Scrophulariae 12-18 part, Radix Bupleuri 5-8 part, stir-fry Fructus Citri tangerinae core 7-11 part, Fructus Trichosanthis 12-18 part, Flos Lonicerae 12-18 part, Spica Prunellae 12-18 part, Pericarpium Citri Reticulatae 12-18 part, Sargassum 12-18 part, Thallus Laminariae (Thallus Eckloniae) 12-18 part, Concha Ostreae 25-35 part.
3. the Chinese medicine composition for the treatment of phlegm-fire stasis type thyroid carcinoma according to claim 1, is characterized in that, be made up of the crude drug of following parts by weight:
Rhizoma Dioscoreae Bulbiferae 8 parts, Rhizoma Sparganii 8 parts, 8 parts, Radix Glycyrrhizae, 16 parts, the Radix Rehmanniae, Radix Scrophulariae 16 parts, Radix Bupleuri 6 parts, stir-fry Fructus Citri tangerinae core 8 parts, Fructus Trichosanthis 16 parts, Flos Lonicerae 16 parts, Spica Prunellae 16, Pericarpium Citri Reticulatae 16 parts, Sargassum 16 parts, Thallus Laminariae (Thallus Eckloniae) 16 parts, Concha Ostreae 30 parts.
4. the preparation method of the Chinese medicine composition described in any one of Claim 1-3, is characterized in that, the mixing of various crude drug is placed in extractor, extracts with water or hydrophilic solvent, concentrated extracting solution and get final product.
5. preparation method as claimed in claim 4, it is characterized in that, described hydrophilic solvent is ethanol, methanol, acetone, butanediol or propylene glycol.
6. preparation method as claimed in claim 4, is characterized in that, specifically comprise the following steps:
Get each taste crude drug, add crude drug 8-16 times water gaging, decoct and extract 2-3 time, each 30-60 minute, obtains decocting liquid, and being concentrated into decocting liquid proportion is 1.15-1.20---and when 40 DEG C, leave standstill 1-2 hour, to obtain final product.
7. treat a Chinese medicine preparation for phlegm-fire stasis type thyroid carcinoma, it is characterized in that, be made up of the Chinese medicine composition described in any one of claim 1-3 and excipient.
8. Chinese medicine preparation according to claim 7, is characterized in that, it is oral liquid, granule, capsule, drop pill, decoction or tablet.
9. the Chinese medicine composition of the treatment phlegm-fire stasis type thyroid carcinoma described in any one of claims 1 to 3 is preparing the application prevented and treated in thyroid carcinoma medicine.
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| CN105902733A (en) * | 2016-05-19 | 2016-08-31 | 李丽丽 | Preparation with thyroid cancer resisting function for ultrasonography and preparation method thereof |
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| JP2009057340A (en) * | 2007-09-03 | 2009-03-19 | Kyushu Univ | Cell proliferation inhibitor |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105878600A (en) * | 2016-05-19 | 2016-08-24 | 李丽丽 | Traditional Chinese medicine preparation for treating thyroid cancer and preparation method thereof |
| CN105902733A (en) * | 2016-05-19 | 2016-08-31 | 李丽丽 | Preparation with thyroid cancer resisting function for ultrasonography and preparation method thereof |
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