CN108578607A

CN108578607A - A kind of pharmaceutical composition for treating kidney stone

Info

Publication number: CN108578607A
Application number: CN201810910351.4A
Authority: CN
Inventors: 王英美
Original assignee: Qingdao Jin Liya Medical New Technology Development Co Ltd
Current assignee: Qingdao Jin Liya Medical New Technology Development Co Ltd
Priority date: 2018-08-10
Filing date: 2018-08-10
Publication date: 2018-09-28

Abstract

The bulk pharmaceutical chemicals of a kind of pharmaceutical composition for treating kidney stone, described pharmaceutical composition are made of Radix Notoginseng, spina date seed, corydalis tuber, setose thistle, Lygodium japonicum, desmodium, Asiatic plantain, honeysuckle, oldenlandia diffusa, eclipta, rhizoma imperatae, paniculate swallowwort, Poria cocos, lophatherum gracile, cape jasmine, corn stigma, purslane, the membrane of a chicken's gizzard, Radix Glycyrrhizae, Radix Paeoniae Alba, the fruit of Chinese wolfberry, dried orange peel, ternip, Herba Epimedii, Rhizoma Chuanxiong, great burdock achene, turtle shell, pueraria lobata, rhizoma atractylodis, gynostemma pentaphylla, cassia twig, wrinkled giant hyssop, coix seed.The selected medicament composing prescription of the present invention, its drug component is through dialectical compatibility, the effect of mutually assistant helps, plays clearing heat and promoting diuresis, Tonglin Paishi, promoting blood circulation and removing blood stasis, kidney and spleen invigorating altogether is being used, nature dissolve stone, lithagogue rate are improved, good effect, it is quick, improve renal function, treating both manifestation and root cause of disease is reached to the treatment of kidney stone, rapid recovery kidney stone is ailing, and radical cure is not recurred.

Description

A kind of pharmaceutical composition for treating kidney stone

Technical field

The invention belongs to pharmaceutical technology fields, are related to a kind of Chinese medicine composition, and in particular to a kind of medicine for treating kidney stone Compositions.

Background technology

Kidney stone is urinary system common disease, and frequently-occurring disease, male, which falls ill, is more than women, mostly occurs in person between twenty and fifty, left and right sides Incidence no significant difference.40%~75% kidney stone patient has different degrees of pain in the back.Calculus is larger, and degree of excursion is very It is small, the swollen discomfort of waist acid is shown as, or have secret anguish or dull pain when body movement increases.It is often rapid compared with the angina that microlith causes The severe pain of waist and belly cut sample so occurs, is in paroxysmal.

Influence calculus factor it is very much, the age, sex, race, heredity, environmental factor, eating habit and occupation with The formation of calculus is related.The metabolic disorder of body, the obstruction of urinary tract, infection, the use of foreign matter and drug are the normal of calculus See the cause of disease.It is calcium oxalate to have known urinary calculi to have 32 kinds of ingredients, modal composition.The calculus of other compositions such as ammonium phosphate Magnesium, uric acid, calcium phosphate and Cystine (a kind of amino acid) etc., can also be the mixture of any of the above ingredient.

Position according to calculus can be divided into：Upper urinary stone includes kidney stone, ureteral calculi；Calculus of lower urinary tract includes wing Guang calculus, urethral calculus.

The patient of kidney stone is mostly without symptom, unless kidney stone falls to the urine that ureter causes ureter from kidney Obstruction.Common symptom has waist and belly angina, Nausea and vomiting, dysphoria, abdominal distension, blood urine etc..If merging urinary tract infections, Phenomena such as chilly fever may also occur.Acute renal colic often makes patient pain unbearably.

Sometimes patient is painless, and only blood urine or blood volume is atomic, visually can't see.Include urine mostly when physical examination Fluid inspection, and have if seeing that red blood cell number has excessively meant that blood urine with the sediment after the centrifugation of microexamination urine When exactly kidney stone early stage sign.

Therapy：Treatment kidney stone is using drug therapy or operative treatment at present, analgesic drug product when breaking out such as angina, If it was found that concurrent infection or obstruction, should use drug infection control, when necessary intra-ureteral cannula or renal plevis fistulization as the case may be, Ensure that urine drainage is unobstructed, is controlled with sharp inflammation, prevent kidney function damage.But though drug therapy has different degrees of curative effect, But there is the deficiency that cannot thoroughly effect a radical cure, and easily recur.

Extracorporeal shock wave lithotripsy method refers to being positioned to the calculus of patient by x-ray or B ultrasound, then utilizes high energy After shock wave focusing, calculus is crushed；The therapy can crush most of kidney stones, be particularly suitable for calculus and be less than 2.5cm Pyelolithiasis patient；But following kidney stone patient is not suitable for using extracorporeal shock wave lithotripsy therapy：1. suffering from hemorrhagic disease The patient of disease；2. the patient of gestation；3. the patient with severe cardiovascular disease；4. there is the patient blocked in calculus distal end；⑤ The patient that urinary tract infections is not controlled；In addition, it is fat, the position of kidney is excessively high, backbone has serious deformity, calculus positioning not Clear kidney stone patient should not also select extracorporeal shock wave lithotripsy therapy.Meanwhile extracorporeal shock-wave lithotomy is calculus is smaller, fat trouble Person is occasionally there are location difficulty, and gravelstone falls into the problems such as ureter causes obstruction after position depth, big energy-consuming, rubble, and effect is not It is highly desirable.

Open operation is the conventional method for treating kidney stone, and kidney stone patient can select according to the concrete condition of oneself Renal plevis takes the methods of stone and partial nephrectomy to be treated through sinus renalis pyelolithotomy, kidney parenchyma incision.This method can Various kidney stones are treated, are primarily adapted for use in the patient for doing Minimally Invasive Surgery with the kidney stone patient and no condition of infection at present； This method is not necessarily to special installation, can handle the various situations of patient's appearance, and the effect for the treatment of is also relatively more definite.The cure pair The damage of patient is larger, and the pain that patient bears is also more, and needs to be hospitalized for a long time.

Invention content

The object of the present invention is to provide a kind of easy, at low cost, significant in efficacy, the without side-effects treatment kidney stones of preparation Pharmaceutical composition.

The above-mentioned purpose of the present invention is realized by following technical proposals：

A kind of pharmaceutical composition for treating kidney stone, the bulk pharmaceutical chemicals of described pharmaceutical composition by Radix Notoginseng, spina date seed, prolong recklessly Rope, setose thistle, Lygodium japonicum, desmodium, Asiatic plantain, honeysuckle, oldenlandia diffusa, eclipta, rhizoma imperatae, paniculate swallowwort, Poria cocos, henon bamboo Leaf, cape jasmine, corn stigma, purslane, the membrane of a chicken's gizzard, Radix Glycyrrhizae, Radix Paeoniae Alba, the fruit of Chinese wolfberry, dried orange peel, ternip, Herba Epimedii, Rhizoma Chuanxiong, great burdock achene, Turtle shell, pueraria lobata, rhizoma atractylodis, gynostemma pentaphylla, cassia twig, wrinkled giant hyssop, coix seed composition.

Further, the bulk pharmaceutical chemicals that described pharmaceutical composition is made form and parts by weight are：12-20 parts of eclipta, ox 10-16 parts of burdock, 3-8 parts of the membrane of a chicken's gizzard, 5-12 parts of wrinkled giant hyssop, 12-17 parts of setose thistle, 7-12 parts of Radix Notoginseng, 4-9 parts of Radix Glycyrrhizae, lophatherum gracile 15- 20 parts, 10-15 parts of spina date seed, 8-12 parts of Poria cocos, 2-5 parts of cape jasmine, 3-7 parts of Asiatic plantain, 11-14 parts of corn stigma, honeysuckle 9-15 Part, 3-6 parts of Lygodium japonicum, 8-13 parts of paniculate swallowwort, 3-5 parts of the fruit of Chinese wolfberry, 1-3 parts of corydalis tuber, 5-10 parts of dried orange peel, oldenlandia diffusa 5-10 Part, 13-16 parts of ternip, 3-10 parts of desmodium, 8-13 parts of Herba Epimedii, 3-5 parts of turtle shell, 1-3 parts of Radix Paeoniae Alba, 5-10 parts of gynostemma pentaphylla, river 3-6 parts of rhizome of chuanxiong, 8-13 parts of rhizoma imperatae, 3-5 parts of pueraria lobata, 11-15 parts of cassia twig, 4-8 parts of rhizoma atractylodis, 13-16 parts of coix seed, purslane 11- 14 parts.

Further, the bulk pharmaceutical chemicals that described pharmaceutical composition is made form and parts by weight are：12 parts of eclipta, great burdock achene 16 parts, 3 parts of the membrane of a chicken's gizzard, 12 parts of wrinkled giant hyssop, 12 parts of setose thistle, 10 parts of Radix Notoginseng, 9 parts of Radix Glycyrrhizae, 15 parts of lophatherum gracile, 15 parts of spina date seed, Poria cocos 8 Part, 5 parts of cape jasmine, 3 parts of Asiatic plantain, 14 parts of corn stigma, 9 parts of honeysuckle, 6 parts of Lygodium japonicum, 8 parts of paniculate swallowwort, 5 parts of the fruit of Chinese wolfberry prolong recklessly 1 part of rope, 10 parts of dried orange peel, 5 parts of oldenlandia diffusa, 16 parts of ternip, 10 parts of desmodium, 8 parts of Herba Epimedii, 5 parts of turtle shell, 1 part of Radix Paeoniae Alba, 10 parts of gynostemma pentaphylla, 6 parts of Rhizoma Chuanxiong, 8 parts of rhizoma imperatae, 3 parts of pueraria lobata, 15 parts of cassia twig, 4 parts of rhizoma atractylodis, 13 parts of coix seed, 14 parts of purslane.

Further, the bulk pharmaceutical chemicals that described pharmaceutical composition is made form and parts by weight are：20 parts of eclipta, great burdock achene 10 parts, 8 parts of the membrane of a chicken's gizzard, 5 parts of wrinkled giant hyssop, 17 parts of setose thistle, 12 parts of Radix Notoginseng, 4 parts of Radix Glycyrrhizae, 20 parts of lophatherum gracile, 10 parts of spina date seed, Poria cocos 12 Part, 2 parts of cape jasmine, 7 parts of Asiatic plantain, 11 parts of corn stigma, 15 parts of honeysuckle, 3 parts of Lygodium japonicum, 13 parts of paniculate swallowwort, 3 parts of the fruit of Chinese wolfberry prolong 3 parts of Hu rope, 5 parts of dried orange peel, 10 parts of oldenlandia diffusa, 13 parts of ternip, 3 parts of desmodium, 13 parts of Herba Epimedii, 3 parts of turtle shell, Radix Paeoniae Alba 3 Part, 5 parts of gynostemma pentaphylla, 4 parts of Rhizoma Chuanxiong, 10 parts of rhizoma imperatae, 4 parts of pueraria lobata, 13 parts of cassia twig, 5 parts of rhizoma atractylodis, 16 parts of coix seed, purslane 11 Part.

Further, the bulk pharmaceutical chemicals that described pharmaceutical composition is made form and parts by weight are：13 parts of eclipta, great burdock achene 11 parts, 4 parts of the membrane of a chicken's gizzard, 6 parts of wrinkled giant hyssop, 13 parts of setose thistle, 7 parts of Radix Notoginseng, 5 parts of Radix Glycyrrhizae, 18 parts of lophatherum gracile, 11 parts of spina date seed, Poria cocos 9 Part, 4 parts of cape jasmine, 6 parts of Asiatic plantain, 12 parts of corn stigma, 13 parts of honeysuckle, 4 parts of Lygodium japonicum, 9 parts of paniculate swallowwort, 4 parts of the fruit of Chinese wolfberry prolong recklessly 2 parts of rope, 6 parts of dried orange peel, 6 parts of oldenlandia diffusa, 14 parts of ternip, 5 parts of desmodium, 10 parts of Herba Epimedii, 4 parts of turtle shell, 2 parts of Radix Paeoniae Alba twist Stock is 6 parts blue, 5 parts of Rhizoma Chuanxiong, 12 parts of rhizoma imperatae, 3 parts of pueraria lobata, 12 parts of cassia twig, 6 parts of rhizoma atractylodis, 14 parts of coix seed, 12 parts of purslane.

Further, the bulk pharmaceutical chemicals that described pharmaceutical composition is made form and parts by weight are：17 parts of eclipta, great burdock achene 15 parts, 7 parts of the membrane of a chicken's gizzard, 11 parts of wrinkled giant hyssop, 16 parts of setose thistle, 8 parts of Radix Notoginseng, 8 parts of Radix Glycyrrhizae, 16 parts of lophatherum gracile, 14 parts of spina date seed, Poria cocos 11 Part, 3 parts of cape jasmine, 5 parts of Asiatic plantain, 13 parts of corn stigma, 14 parts of honeysuckle, 5 parts of Lygodium japonicum, 12 parts of paniculate swallowwort, 3 parts of the fruit of Chinese wolfberry prolong 1 part of Hu rope, 10 parts of dried orange peel, 9 parts of oldenlandia diffusa, 13 parts of ternip, 7 parts of desmodium, 11 parts of Herba Epimedii, 3 parts of turtle shell, Radix Paeoniae Alba 1 Part, 10 parts of gynostemma pentaphylla, 4 parts of Rhizoma Chuanxiong, 11 parts of rhizoma imperatae, 4 parts of pueraria lobata, 14 parts of cassia twig, 7 parts of rhizoma atractylodis, 15 parts of coix seed, purslane 13 Part.

Further, the bulk pharmaceutical chemicals that described pharmaceutical composition is made form and parts by weight are：15 parts of eclipta, great burdock achene 12 parts, 5 parts of the membrane of a chicken's gizzard, 9 parts of wrinkled giant hyssop, 15 parts of setose thistle, 9 parts of Radix Notoginseng, 7 parts of Radix Glycyrrhizae, 19 parts of lophatherum gracile, 13 parts of spina date seed, Poria cocos 10 Part, 4 parts of cape jasmine, 4 parts of Asiatic plantain, 11 parts of corn stigma, 11 parts of honeysuckle, 5 parts of Lygodium japonicum, 10 parts of paniculate swallowwort, 5 parts of the fruit of Chinese wolfberry prolong 3 parts of Hu rope, 8 parts of dried orange peel, 8 parts of oldenlandia diffusa, 14 parts of ternip, 9 parts of desmodium, 12 parts of Herba Epimedii, 5 parts of turtle shell, 3 parts of Radix Paeoniae Alba, 8 parts of gynostemma pentaphylla, 6 parts of Rhizoma Chuanxiong, 9 parts of rhizoma imperatae, 5 parts of pueraria lobata, 12 parts of cassia twig, 7 parts of rhizoma atractylodis, 13 parts of coix seed, 11 parts of purslane.

Further, the bulk pharmaceutical chemicals that described pharmaceutical composition is made form and parts by weight are：19 parts of eclipta, great burdock achene 14 parts, 6 parts of the membrane of a chicken's gizzard, 7 parts of wrinkled giant hyssop, 14 parts of setose thistle, 9 parts of Radix Notoginseng, 6 parts of Radix Glycyrrhizae, 17 parts of lophatherum gracile, 13 parts of spina date seed, Poria cocos 10 Part, 4 parts of cape jasmine, 4 parts of Asiatic plantain, 11 parts of corn stigma, 11 parts of honeysuckle, 5 parts of Lygodium japonicum, 10 parts of paniculate swallowwort, 5 parts of the fruit of Chinese wolfberry prolong 3 parts of Hu rope, 8 parts of dried orange peel, 8 parts of oldenlandia diffusa, 14 parts of ternip, 4 parts of desmodium, 9 parts of Herba Epimedii, 5 parts of turtle shell, 3 parts of Radix Paeoniae Alba, 8 parts of gynostemma pentaphylla, 3 parts of Rhizoma Chuanxiong, 8 parts of rhizoma imperatae, 5 parts of pueraria lobata, 15 parts of cassia twig, 8 parts of rhizoma atractylodis, 16 parts of coix seed, 14 parts of purslane.

Further, described pharmaceutical composition uses following preparation steps：

(1) each medicinal material of components by weight percent in any described pharmaceutical compositions of claim 3-8 is taken, decocts dosing material for the first time 10-15 times of water boiling and extraction of total weight decocts 1-2 hours：The 8-12 times of water measured of second of addition, decocts 1-1.2h, filter It is for use to go out liquid；The 8-12 times of water measured is added in third time, decocts 0.8-1.2h, it is for use to filter out liquid；Merge decocting liquid three times, mistake Filtrate is collected in filter, and relative density is the clear cream of 1.10-1.30 when being concentrated into 50-60 DEG C；

(2) clear cream made from step (1) is placed to room temperature, ethyl alcohol is added to make containing amount of alcohol to weight percent 60- 75%, 24-48 hours are stood, supernatant is taken；Supernatant recycles ethyl alcohol, and relative density is 1.20- when being concentrated under reduced pressure into 50-60 DEG C 1.30 clear cream then centrifuges under the rotating speed of 3000r/min；In 60 DEG C of -80 DEG C of spray drying, dry extract is obtained；

(3) dry extract made from step (2) is put into micronizer and is crushed 1-2 hours, be sieved, obtain 100-200 Suitable amount of sucrose, dextrin mixing is added in purpose micropowders, and using ethyl alcohol as wetting agent, granulation is dry, and particle can be made in whole grain Agent；Or crushed being put into micronizer after dry extract drying made from step (2) 1-2 hours, it is sieved, obtains 100- The micropowders of 200 mesh, are made powder；Or by dry extract made from step (2) be put into micronizer crush 1-2 it is small When, sieving obtains the micropowders of 100-200 mesh, and appropriate superfine silica gel powder, α-galactolipin mixing is added, using ethyl alcohol as wetting agent, Granulation, dry, whole grain is encapsulated, and capsule is made；Or dry extract made from step (2) is put into powder in micronizer 1-2 hours broken, sieving obtains the micropowders of 100-200 mesh, and suitable amount of sucrose, dextrin mixing is added, using ethyl alcohol as wetting agent, Tablet is made in granulation, dry, whole grain, tabletting；Or it is added in the concentrate after the centrifugation obtained to above-mentioned steps (2) appropriate Sucrose, essence mixing, sterilizing is filling, and liquid agent is made.

The invention further relates to a kind of application of described pharmaceutical composition in treating kidney stone drug.

The pharmaceutical composition for the treatment of kidney stone provided by the present invention gives full play to using common Chinese herbal medicine as raw material The pharmacological property of each component：

Radix Notoginseng：Warm-natured, sweet in flavor, slight bitter, Return liver, stomach have hemostasis, dissipate the stasis of blood, detumescence, and the effect of analgesic cures mainly：It controls and spits Blood, hemoptysis, bleeding from five sense organs or subcutaneous tissue are had blood in stool, bloody flux, uterine bleeding, abdominal mass, postpartum anemic fainting, lochia not under, fall and flutter hemostasis, traumatic hemorrhage, carbuncle swells pain Deng card, modern pharmacology proves, Radix Notoginseng can stop blooding, antithrombotic, promote hematopoiesis, anti-inflammatory, liver protection, antitumor, analgesia, to angiocarpy There is good effect, has protective effect to myocardial damage.

Spina date seed：Base：For the seed of rhamnaceae plant wild jujube.Chemical analysis：It is main to contain two kinds of triterpenoids：White birch fat Alcohol, betulic acid.Separately contain jujuboside, glucoside member is jujubogenin, hydrolyzes the second step that obtained Ebelin Lactone is saponin Product.Also vitamin C containing volume.Pharmacological action：1. calm, syngignoscism, 2. analgesia, anticonvulsion, cooling effect, 3. to painstaking effort The influence of guard system, 4. to the influence of burn.Nature and flavor：Sweet and neutral.Channel tropism：Enter the heart, spleen, liver, gallbladder channel.Major function：Nourishing the liver, rather The heart is calmed the nerves, arrest sweating.Restlessness of asrhenia type and insomnia is controlled, palpitation of palpitating with fear, polydipsia, abnormal sweating.

Corydalis tuber, it is bitter, pungent, it is warm-natured；Return liver, the heart, stomach；Benefaction is wandered away, and can rise can drop, and has promoting blood circulation to remove blood stasis, promoting the circulation of qi The effect of analgesic.Cure mainly chest impediment and cardialgia, side of body rib, all pains of gastral cavity abdomen, headache, pain in the back, hernia pain, muscle and bone ache, dysmenorrhoea, Amenorrhea, postpartum Stasis of blood abdominal pain, traumatic injury.

Setose thistle, main component are fragrant containing alkaloid, volatile oil, taraxasterylacetate, stigmasterol, mono- amyrins of a, B- Jis Resinol, B- sitosterol, Linaria vulgaris flower glucoside 2-1%, sweet in flavor, bitter, cool in nature, nontoxic, converge to heart and liver channels have cool blood, stop blooding, disappear Bitterly, the effect of detoxifying, controls the illnesss such as haematemesis, bleeding from five sense organs or subcutaneous tissue, hematuria, blood strangury, metrorrhagia, intestines wind, acute appendicitis, large carbuncle pyogenic infections, furunculosis.

Lygodium japonicum：For the drying and ripening spore of Lygodiaceae plant Lygodium japonicum Lygodium japonicum (Thunb.) Sw. Son.Autumn spore taps cane leaves when not falling off, and dries, and crumples or lay spore, removes cane leaves.Nature and flavor and channel tropism：It is sweet, salty, it trembles with fear, Return bladder, small intestinl channel.Function with cure mainly：Eliminating dampness and heat, treating stranguria analgesic.For heat gonorrhea, urolithiasis, blood strangury, cream leaching, Urethra astringent pain.

Desmodium：For the drying herb of Ofthe Primulaceae Lysimachia christinae Lysimachia christinae Hance.Summer, Qiu Erji is harvested, and is removed impurity, is dried.Nature and flavor and channel tropism：It is sweet, salty, it is slightly cold, Return liver, courage, kidney, bladder warp.Function with cure mainly： Pierce wet removing jaundice, inducing diuresis for treating strangurtia, removing toxicity for detumescence.For jaundice with damp-heat pathogen, hypochondriac pain that courage is swollen, urolithiasis, heat gonorrhea, difficulty and pain in micturition, carbuncle swells furunculosis, Snakebite and bugbite.

Asiatic plantain：For plantago plant Chinese herbaceous peony Plantago asiatica L. or ordinary building Plantago depressa Willd. drying herb.Summer excavates, and removes silt, dries.Nature and flavor and channel tropism：It is sweet, it trembles with fear, Return liver, kidney, lung, small intestinl channel.Work( Can with cure mainly：Reducing fever and causing diuresis is treating stranguria, eliminating the phlegm, cool blood, removing toxic substances.For puckery pain of heat gonorrhea, oedema oliguria, summer heat damp diarrhea, phlegm-heat cough, Hematemesis and epistaxis, carbuncle sore tumefacting virus.

Honeysuckle, nature and flavor：It is sweet in flavor, cold in nature, have clearing heat and detoxicating, dispelling wind and heat from the body, dredge throat, relieve summer heat relieving restlessness the effect of, For treating the illnesss such as summer fever, rush down dysentery, influenza, sore furuncle poison, acute and chronic tonsillitis, periodontitis.

Oldenlandia diffusa：Mildly bitter flavor, it is cold in nature.Enter stomach, large intestine, small intestinl channel.Clearing heat and detoxicating, dampness removing is treating stranguria.It is breathed heavily for lung heat Cough, abscess of throat, acute appendicitis, furuncle sore, venomous snake bite, puckery pain of heat gonorrhea, oedema, dysentery, enteritis, jaundice with damp-heat pathogen, cancerous swelling.

Eclipta, sweet in flavor, acid is cool in nature, returns liver and kidney channel, tonifies the liver and kidney；Cooling blood and hemostasis.Main kidney deficiency and liver；It has a dizzy spell； Poliosis；It spits blood；Spitting of blood；Bleeding from five sense organs or subcutaneous tissue；It has blood in stool；Bloody flux；It collapses；Leakage；Traumatic hemorrhage.

Rhizoma imperatae, it is sweet, it trembles with fear.Return lung, stomach, bladder warp.Major function：Cooling blood and hemostasis, reducing fever and causing diuresis.It spits blood for blood-head, Bleeding from five sense organs or subcutaneous tissue, hematuria, pyreticosis polydipsia, jaundice, oedema, puckery pain of heat gonorrhea；Acute nephritis edema.

Paniculate swallowwort cures mainly:Analgesia, cough-relieving, inducing diuresis for removing edema, promoting blood circulation and detoxication.It treats for stomachache, has a toothache, rheumatalgia pain, menstrual period abdomen Bitterly, chronic bronchitis, ascites, oedema, dysentery, enteritis, traumatic injury, eczema, nettle rash, venomous snake bite.1, it is used for rheumatism numbness Bitterly, the various pains such as pain in the back, traumatic injury pain, abdominal pain, toothache.Paniculate swallowwort has preferable wind-expelling pain-stopping to act on, widely For rheumatism, cold solidifying, caused by the stagnation of the circulation of vital energy, blood stasis various pains.It is also used for postoperative pain and cancerous swelling pain in recent years, has certain Analgesic effect.Can single application, or with the related drug of card compatibility.2, with skin diseases such as eczema, wheal, stubborn dermatitis.This product There is dispelling wind and arresting itching effect.For oral administration or decoction washout can be applied alone, also can the eliminating dampness and heat such as compatibility kuh-seng, the fruit of summer cypress, the root bark of shaggy-fruited dittany medicine Object.In addition, this product can also antidote against snake bite, venomous snake bite is controlled.It can be with the same for oral administration or external application of Chinese lobelia.

Poria cocos：Nature and flavor and channel tropism：It is sweet, light, it puts down.The thoughts of returning home, lung, spleen, kidney channel.There is the effect of clearing damp and promoting diuresis, invigorating the spleen, calming heart. For oedema oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.

Lophatherum gracile：It is sweet in flavor, light, it is cold in nature.There is the effect of clearing heat and relieving fidgetness, diuresis, is used for pyreticosis polydipsia, hot urination drenches pain, Aphthae.

Its cold in nature, bitter of cape jasmine, function with cure mainly：Purging intense heat relieving restlessness, clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body,《Sheng Nong's herbal classic》： " cure mainly perverse trend in five, white leprosy, red leprosy, sore ....”

Corn stigma：Diuresis expels the heat-evil, soothing the liver, cholagogic.Control nephritic dropsy, tinea pedis, icterohepatitis, hypertension, cholecystitis, courage Calculus, diabetes, hematemesis and epistaxis, nasosinusitis, acute mastitis.The present invention selects the style and column of grass maize ZeamaysL. Head.

Purslane：For the dry aerial parts of portulacaceous plant purslane Portulaca oleracea L..Summer, autumn Two seasons harvested, and removed undesirable root and impurity, cleaned, and slightly steamed or were dried after scalding.Nature and flavor and channel tropism：Acid is trembled with fear, Return liver, large intestine channel.Function With cure mainly：It is clearing heat and detoxicating, cooling blood and hemostasis, stop dysentery.For toxic-heat and blood stasis, carbuncle swells treat sore, eczema, erysipelas, and snakebite and bugbite are had blood in stool, Hemorrhoid blood, metrostaxis.

The membrane of a chicken's gizzard：For the drying inner wall of sandbag of Phasianidae animal family chicken Gallus gallus domesticus Brisson. After killing chicken, chicken gizzard is taken out, peels inner wall, cleaning, drying immediately.Nature and flavor and channel tropism sweet and neutral.Returns spleen, stomach, small intestine, bladder warp.Work( Can with cure mainly stomach strengthening and digestion promoting, arresting seminal emission, treating stranguria fossil.For dyspepsia, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission, The puckery pain of urolithiasis, hypochondriac pain that courage is swollen.

Radix Glycyrrhizae：For glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza The dry root and rhizome of inflate Bat. or glycyrrhiza glabra Glycyrrhiza glabra L..Spring, the excavation of two season of autumn remove Fibrous root dries.Nature and flavor and channel tropism：Sweet and neutral, the thoughts of returning home, lung, spleen, stomach.Function with cure mainly：It invigorates the spleen and benefits qi, clearing heat and detoxicating, eliminating the phlegm Cough-relieving, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction are anxious Pain, carbuncle sore tumefacting virus alleviate drug toxicity, strong.

Radix Paeoniae Alba：For the dry root of ranunculaceae plant Chinese herbaceous peony Paeonia lactiflora Pall..Summer, the excavation of two season of autumn, It cleans, removes end to end and radicula, set and boiled again after removing crust or peeling after being boiled in boiling water, dried.Nature and flavor and channel tropism：Bitter, acid, it is micro- It is cold, Return liver, the spleen channel.Function with cure mainly：Nourishing blood for regulating menstruation, astringing YIN to stop sweating, soft liver analgesic, suppressing liver-YANG.For blood deficiency chlorosis, menstruation It is uncomfortable, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, four limbs contraction pain, dizziness of having a headache.

The fruit of Chinese wolfberry：For the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Summer, two season of autumn fruit It is harvested when taking on a red color in fact, hot-air seasoning, removes carpopodium, or dry in the air to rhicnosis, dry, remove carpopodium.Nature and flavor and channel tropism：Sweet and neutral, Return liver and kidney channel.Function with cure mainly：It is nourishing liver and kidney, benefiting shrewd head.For consumption consumptive loss, soreness of waist and knee joint, dizziness and tinnitus, impotence something lost Essence, Heat Diabetes, blood deficiency chlorosis, blurred vision.

Dried orange peel is warm-natured, acrid flavour, bitter.Enter the spleen channel, stomach, lung channel.Regulating qi-flowing for strengthening spleen, in tune, eliminating dampness, resolving sputum.Cure mainly taste The abdominal fullness and distention or pain of the stagnation of the circulation of vital energy, indigestion.Abdominal distension uncomfortable in chest, indigestion and loss of appetite loose stool in wet turbid resistance.The cough and asthma of phlegm obstructing lung. For chest gastral cavity turgor, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.《Compendium of Materia Medica》：It is to hundred and always takes the work(of chess qi-regulating eliminating dampness, same to tonic It then mends, is then rushed down with cathartic, then risen with hydrargyrum oxydatum crudum, then dropped with medicine is dropped.Spleen is the mother of vigour, and lung is taking the photograph wanting for gas, therefore orange peel is two warps Qi leel is wanted, but with match and reinforcing and reducing methods lift.《Daily book on Chinese herbal medicine》：Can dissipate can rush down, and warm can mend, and can disappear diaphragm gas, resolving sputum saliva, and Spleen is only coughed, and five leaching are led to.

Ternip also known as radish, reed Fu, warm ancient name for Chinese cabbage, soil are crisp, and property acrid, sweet, cool enters lung, stomach, has and eliminates indigestion and phlegm, lower gas Effect in width.Contain mustard oil and amylase in ternip, therefore has acid, can be aid digestion, increase appetite；Wherein also contain A certain amount of crude fibre can promote gastrointestinal peristalsis, tonneau stool；Also there is relieving cough and reducing sputum effect simultaneously, to flu, meningitis, white The infectious diseases such as larynx have certain prevention effect.

Herba Epimedii, acrid flavour, sweet, warm-natured, return liver warp, kidney channel.Energy kidney-replenishing, strengthening the bones and muscles, wind-damp dispelling.For impotence and seminal emission, Muscles and bones impotence, arthralgia pain due to rheumatism, numbness contracture；Climacteric hypertension.

Rhizoma Chuanxiong, nature and flavor are acrid in flavour and warm in nature.Enter liver, gallbladder channel.Promote breath and open depression is cured mainly, method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache rotation It is dizzy, hypochondriac pain abdomen pain, arthritis muscle contraction, Amenorrhea, difficult labour, postpartum stasis block pain, ulcer sores.For irregular menstruation, closed dysmenorrhea, lump in the abdomen Abdominal pain, chest side of body shouting pain, tumbling and swelling, headache, arthralgia pain due to rheumatism.

Great burdock achene：Have effects that dispelling wind and heat from the body, facilitaing lung promoting eruption, relieving sore-throat dissipating bind, removing toxicity for detumescence, cures mainly cough due to wind-heat evil, pharynx Larynx swells and ache, macula is impermeable, rubella itch, sore swollen toxin.Drying and ripening selected from feverfew burdock Arctium lappa L. Fruit.

Turtle shell, it is salty, it is slightly cold.Return liver and kidney channel.Major function：Nourishing and suppressing Yang, softening and resolving hard mass are brought down a fever except steaming.It is sent out for the deficiency of Yin Heat, the hot hectic fever due to yin of labor, endogenous deficient wind, Amenorrhea , wei lumps in the abdomen, chronic malaria malaria with abdominal mass.

Pueraria lobata, it is sweet in flavor, pungent, it is cool in nature.Enter spleen, stomach.With rising Yang expelling pathogenic factors from muscles and skin, promoting eruption antidiarrheal, relieving restlessness stops effect of temperature.For Typhoid fever, warm headache Xiang Qiang, dysphoria with smothery sensation are quenched one's thirst, and diarrhea, dysentery, ecchymosis is impermeable, hypertension, angina pectoris, deaf.Clinically it is used for controlling High blood pressure neck pain, coronary disease and angina pectoris are treated, but also there is hypoglycemic effect.

Rhizoma atractylodis acrid flavour, hardship, it is warm-natured.Returns spleen, stomach, Liver Channel.Major function：It is drying damp and strengthening spleen, expelling wind and clearing away cold.It is swollen for gastral cavity abdomen It is full, diarrhea oedema.

Gynostemma pentaphylla：It is sweet in flavor, bitter, cold nature；Distributed in lung channel, the spleen channel, kidney channel.Energy QI invigorating, calms the nerves, blood pressure lowering is clearing heat and detoxicating, only Cough eliminating the phlegm.After small number of patients medication, there are the symptoms such as nausea and vomiting, abdominal distension diarrhea (or constipation), dizziness, dim eyesight, tinnitus.

Cassia twig acrid, sweet, warm.The thoughts of returning home, lung, bladder warp.Expelling cold and relieving exterior syndrome；Warming meridian；Activating YANG and prormoting functioning of QI.Sweating expelling pathogenic factors from muscles and skin, Wen Tong Passages through which vital energy circulates, helps yang transforming qi, flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, blood trembles with fear Amenorrhea, joint pain, phlegm and retained fluid, oedema, the heart Throb with fear, run quickly globefish.1. antibacterial action:Cassia twig alcohol extract can inhibit Escherichia coli, hay bacillus and staphylococcus aureus in vitro, have Imitate a concentration of 25mg/ml or following；To staphylococcus albus, Shigella shigae, Typhoid and paratyphoid first bacillus, pneumonia ball Bacterium, aerobacteria, proteus, bacillus anthracis, Bacterium enteritidis, comma bacillus etc. also have inhibiting effect (tablet dig a hole method) 2. antivirus action：With the primary adhesion tissue cultures of human embryo kidney (HEK), cassia twig decoction (1: 20) is to influenza Asia A type capital Section 68-l plants has inhibiting effect with orphan virus (ECHO11).In chicken embryo, infected by influenza has inhibiting effect, with 70% alcohol leaching Agent effect is preferable.

Wrinkled giant hyssop, pungent, tepor.Such as lung, spleen, stomach.Major function：Fast gas, and in, dirty, clearing damp is warded off, cure cold summer-heat and damp, trembles with fear Heat, headache, chest wrist ruffian is bored, vomiting and diarrhea, malaria, dysentery, halitosis.

Coix seed：Enter spleen, lung, kidney channel.Invigorating the spleen, tonifying lung, heat-clearing, dampness removing.Diarrhea, arthritis with fixed pain caused by dampness are controlled, muscle arteries and veins contraction is bent and stretched not Profit, oedema, tinea pedis, consumptive lung disease, lung carbuncle, acute appendicitis, stranguria with turbid discharge, leukorrhea.

Motherland's medicine thinks the scopes such as kidney stone category Chinese medicine " urolithiasis ", " blood strangury ", " pain in the back ".Kidney stone mostly because it is lower it is cloudy not It is clean, foul heresy from lower intrusion body, by the heat evil for the diseases caused by external factors such as small intestine heat symptoms caused by an exopathgen, the heart channel of Hang-Shaoyin be burning hot be passed to bladder or it is damp and hot accumulate long, Urine is endured at caused by stone.

In the pharmaceutical composition of the present invention, Lygodium japonicum eliminating dampness and heat, treating stranguria analgesic, the wet removing jaundice of money bur, diuresis is logical Leaching, removing toxicity for detumescence, Asiatic plantain reducing fever and causing diuresis is treating stranguria, eliminating the phlegm, cool blood, and removing toxic substances, oldenlandia diffusa is clearing heat and detoxicating, and dampness removing is treating stranguria, chicken The interior treating stranguria fossil of gold, Lygodium japonicum, desmodium, Asiatic plantain, oldenlandia diffusa, the membrane of a chicken's gizzard are monarch drug in a prescription；Honeysuckle is clearing heat and detoxicating, evacuates Wind-heat dredges throat, relieving restlessness of relieving summer heat, rhizoma imperatae cooling blood and hemostasis, reducing fever and causing diuresis, paniculate swallowwort inducing diuresis for removing edema, promoting blood circulation and detoxication, Poria cocos profit Water excreting dampness, invigorating the spleen, calming heart, lophatherum gracile clearing heat and relieving fidgetness, diuresis, cape jasmine purging intense heat relieving restlessness, clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body, corn stigma profit Urine, expels the heat-evil, and soothing the liver, cholagogic, the fruit of Chinese wolfberry is nourishing liver and kidney, benefiting shrewd head, Herba Epimedii kidney-replenishing, strengthening the bones and muscles, wind-damp dispelling, honeysuckle, Rhizoma imperatae, paniculate swallowwort, Poria cocos, lophatherum gracile, cape jasmine, corn stigma, the fruit of Chinese wolfberry, Herba Epimedii are ministerial drug；Pseudo-ginseng hemostatic dissipates the stasis of blood, subsides a swelling, Analgesic, spina date seed nourishing the liver, calming heart are calmed the nerves, arrest sweating, corydalis tuber promoting blood circulation to remove blood stasis, promoting qi circulation and relieving pain, and setose thistle cool blood is stopped blooding, the pain that disappears, solution Poison, eclipta are tonified the liver and kidney, and cooling blood and hemostasis, purslane is clearing heat and detoxicating, cooling blood and hemostasis, stop dysentery, and Radix Paeoniae Alba nourishing blood for regulating menstruation is held back the moon and stopped Sweat, soft liver relieve pain, suppressing liver-YANG, dried orange peel regulating qi-flowing for strengthening spleen, and in tune, eliminating dampness, resolving sputum, ternip eliminates indigestion and phlegm, during lower gas is wide, river Rhizome of chuanxiong promote breath and open depression, method wind-dryness is wet, promoting blood circulation and stopping pain, great burdock achene dispelling wind and heat from the body, facilitaing lung promoting eruption, relieving sore-throat dissipating bind, removing toxicity for detumescence, and turtle shell is grown Cloudy checking exuberance of yang, softening and resolving hard mass are brought down a fever except steaming, and pueraria lobata rising Yang expelling pathogenic factors from muscles and skin, promoting eruption antidiarrheal, relieving restlessness is only warm, and rhizoma atractylodis are drying damp and strengthening spleen, and wind-dispelling dissipates Cold, gynostemma pentaphylla QI invigorating is calmed the nerves, and blood pressure lowering is clearing heat and detoxicating, cough-relieving apophlegmatic, cassia twig expelling cold and relieving exterior syndrome, warming meridian, activating YANG and prormoting functioning of QI, the leaves of pulse plants Fragrant fast gas, and in, ward off dirty, clearing damp, coix seed invigorating the spleen, tonifying lung, heat-clearing, dampness removing, Radix Notoginseng, spina date seed, corydalis tuber, setose thistle, ink drought Lotus, purslane, Radix Paeoniae Alba, dried orange peel, ternip, Rhizoma Chuanxiong, great burdock achene, turtle shell, pueraria lobata, rhizoma atractylodis, gynostemma pentaphylla, cassia twig, wrinkled giant hyssop, coix seed For adjutant；Radix Glycyrrhizae has effects that invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription, to make medicine.This hair Bright selected medicament composing prescription, drug component help using mutually assistant through dialectical compatibility, play clearing heat and promoting diuresis, Tonglin Paishi, work altogether The effect of blood stagnation resolvation, kidney and spleen invigorating, improves nature dissolve stone, lithagogue rate, and good effect is quick, improves renal function, to kidney stone Treatment reaches treating both manifestation and root cause of disease, and rapid recovery kidney stone is ailing, and radical cure is not recurred.

Specific implementation mode

In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with embodiment to this hair Bright technical solution is clearly and completely described.Obviously, described embodiment is the part of the present invention, rather than complete The embodiment in portion.Based on described the embodiment of the present invention, those of ordinary skill in the art are before without creative work The every other embodiment obtained is put, shall fall within the protection scope of the present invention.Unless otherwise indicated, the ethyl alcohol in the present invention The percentage of amount is percentage by volume, and v/v indicates the volume ratio of solution.

Embodiment 1：

A kind of pharmaceutical composition for treating kidney stone of the present invention, takes following traditional Chinese medicine raw medicine：12 grams of eclipta, great burdock achene 16 grams, 3 grams of the membrane of a chicken's gizzard, 12 grams of wrinkled giant hyssop, 12 grams of setose thistle, 10 grams of Radix Notoginseng, 9 grams of Radix Glycyrrhizae, 15 grams of lophatherum gracile, 15 grams of spina date seed, Poria cocos 8 Gram, 5 grams of cape jasmine, 3 grams of Asiatic plantain, 14 grams of corn stigma, 9 grams of honeysuckle, 6 grams of Lygodium japonicum, 8 grams of paniculate swallowwort, 5 grams of the fruit of Chinese wolfberry, prolong recklessly 1 gram of rope, 10 grams of dried orange peel, 5 grams of oldenlandia diffusa, 16 grams of ternip, 10 grams of desmodium, 8 grams of Herba Epimedii, 5 grams of turtle shell, 1 gram of Radix Paeoniae Alba, 10 grams of gynostemma pentaphylla, 6 grams of Rhizoma Chuanxiong, 8 grams of rhizoma imperatae, 3 grams of pueraria lobata, 15 grams of cassia twig, 4 grams of rhizoma atractylodis, 13 grams of coix seed, 14 grams of purslane.

Embodiment 2：

A kind of pharmaceutical composition for treating kidney stone of the present invention, takes following traditional Chinese medicine raw medicine：20 grams of eclipta, great burdock achene 10 grams, 8 grams of the membrane of a chicken's gizzard, 5 grams of wrinkled giant hyssop, 17 grams of setose thistle, 12 grams of Radix Notoginseng, 4 grams of Radix Glycyrrhizae, 20 grams of lophatherum gracile, 10 grams of spina date seed, Poria cocos 12 Gram, 2 grams of cape jasmine, 7 grams of Asiatic plantain, 11 grams of corn stigma, 15 grams of honeysuckle, 3 grams of Lygodium japonicum, 13 grams of paniculate swallowwort, 3 grams of the fruit of Chinese wolfberry prolongs 3 grams of Hu rope, 5 grams of dried orange peel, 10 grams of oldenlandia diffusa, 13 grams of ternip, 3 grams of desmodium, 13 grams of Herba Epimedii, 3 grams of turtle shell, Radix Paeoniae Alba 3 Gram, 5 grams of gynostemma pentaphylla, 4 grams of Rhizoma Chuanxiong, 10 grams of rhizoma imperatae, 4 grams of pueraria lobata, 13 grams of cassia twig, 5 grams of rhizoma atractylodis, 16 grams of coix seed, purslane 11 Gram.

Embodiment 3：

A kind of pharmaceutical composition for treating kidney stone of the present invention, takes following traditional Chinese medicine raw medicine：13 grams of eclipta, great burdock achene 11 grams, 4 grams of the membrane of a chicken's gizzard, 6 grams of wrinkled giant hyssop, 13 grams of setose thistle, 7 grams of Radix Notoginseng, 5 grams of Radix Glycyrrhizae, 18 grams of lophatherum gracile, 11 grams of spina date seed, Poria cocos 9 Gram, 4 grams of cape jasmine, 6 grams of Asiatic plantain, 12 grams of corn stigma, 13 grams of honeysuckle, 4 grams of Lygodium japonicum, 9 grams of paniculate swallowwort, 4 grams of the fruit of Chinese wolfberry, prolong recklessly 2 grams of rope, 6 grams of dried orange peel, 6 grams of oldenlandia diffusa, 14 grams of ternip, 5 grams of desmodium, 10 grams of Herba Epimedii, 4 grams of turtle shell, 2 grams of Radix Paeoniae Alba twist Stock is 6 grams blue, 5 grams of Rhizoma Chuanxiong, 12 grams of rhizoma imperatae, 3 grams of pueraria lobata, 12 grams of cassia twig, 6 grams of rhizoma atractylodis, 14 grams of coix seed, 12 grams of purslane.

Embodiment 4：

A kind of pharmaceutical composition for treating kidney stone of the present invention, takes following traditional Chinese medicine raw medicine：17 grams of eclipta, great burdock achene 15 grams, 7 grams of the membrane of a chicken's gizzard, 11 grams of wrinkled giant hyssop, 16 grams of setose thistle, 8 grams of Radix Notoginseng, 8 grams of Radix Glycyrrhizae, 16 grams of lophatherum gracile, 14 grams of spina date seed, Poria cocos 11 Gram, 3 grams of cape jasmine, 5 grams of Asiatic plantain, 13 grams of corn stigma, 14 grams of honeysuckle, 5 grams of Lygodium japonicum, 12 grams of paniculate swallowwort, 3 grams of the fruit of Chinese wolfberry prolongs 1 gram of Hu rope, 10 grams of dried orange peel, 9 grams of oldenlandia diffusa, 13 grams of ternip, 7 grams of desmodium, 11 grams of Herba Epimedii, 3 grams of turtle shell, Radix Paeoniae Alba 1 Gram, 10 grams of gynostemma pentaphylla, 4 grams of Rhizoma Chuanxiong, 11 grams of rhizoma imperatae, 4 grams of pueraria lobata, 14 grams of cassia twig, 7 grams of rhizoma atractylodis, 15 grams of coix seed, purslane 13 Gram.

Embodiment 5：

A kind of pharmaceutical composition for treating kidney stone of the present invention, takes following traditional Chinese medicine raw medicine：15 grams of eclipta, great burdock achene 12 grams, 5 grams of the membrane of a chicken's gizzard, 9 grams of wrinkled giant hyssop, 15 grams of setose thistle, 9 grams of Radix Notoginseng, 7 grams of Radix Glycyrrhizae, 19 grams of lophatherum gracile, 13 grams of spina date seed, Poria cocos 10 Gram, 4 grams of cape jasmine, 4 grams of Asiatic plantain, 11 grams of corn stigma, 11 grams of honeysuckle, 5 grams of Lygodium japonicum, 10 grams of paniculate swallowwort, 5 grams of the fruit of Chinese wolfberry prolongs 3 grams of Hu rope, 8 grams of dried orange peel, 8 grams of oldenlandia diffusa, 14 grams of ternip, 9 grams of desmodium, 12 grams of Herba Epimedii, 5 grams of turtle shell, 3 grams of Radix Paeoniae Alba, 8 grams of gynostemma pentaphylla, 6 grams of Rhizoma Chuanxiong, 9 grams of rhizoma imperatae, 5 grams of pueraria lobata, 12 grams of cassia twig, 7 grams of rhizoma atractylodis, 13 grams of coix seed, 11 grams of purslane.

Embodiment 6：

A kind of pharmaceutical composition for treating kidney stone of the present invention, takes following traditional Chinese medicine raw medicine：19 grams of eclipta, great burdock achene 14 grams, 6 grams of the membrane of a chicken's gizzard, 7 grams of wrinkled giant hyssop, 14 grams of setose thistle, 9 grams of Radix Notoginseng, 6 grams of Radix Glycyrrhizae, 17 grams of lophatherum gracile, 13 grams of spina date seed, Poria cocos 10 Gram, 4 grams of cape jasmine, 4 grams of Asiatic plantain, 11 grams of corn stigma, 11 grams of honeysuckle, 5 grams of Lygodium japonicum, 10 grams of paniculate swallowwort, 5 grams of the fruit of Chinese wolfberry prolongs 3 grams of Hu rope, 8 grams of dried orange peel, 8 grams of oldenlandia diffusa, 14 grams of ternip, 4 grams of desmodium, 9 grams of Herba Epimedii, 5 grams of turtle shell, 3 grams of Radix Paeoniae Alba, 8 grams of gynostemma pentaphylla, 3 grams of Rhizoma Chuanxiong, 8 grams of rhizoma imperatae, 5 grams of pueraria lobata, 15 grams of cassia twig, 8 grams of rhizoma atractylodis, 16 grams of coix seed, 14 grams of purslane.

Embodiment 7：

A kind of pharmaceutical composition for treating kidney stone of the present invention, takes following traditional Chinese medicine raw medicine：22 parts of eclipta, great burdock achene 9 parts, 9 parts of the membrane of a chicken's gizzard, 4 parts of wrinkled giant hyssop, 15 parts of setose thistle, 6 parts of Radix Notoginseng, 10 parts of Radix Glycyrrhizae, 15 parts of lophatherum gracile, 15 parts of spina date seed, Poria cocos 13 Part, 6 parts of cape jasmine, 2 parts of Asiatic plantain, 15 parts of corn stigma, 16 parts of honeysuckle, 5 parts of Lygodium japonicum, 7 parts of paniculate swallowwort, 8 parts of the fruit of Chinese wolfberry prolong recklessly 2 parts of rope, 8 parts of dried orange peel, 7 parts of oldenlandia diffusa, 18 parts of ternip, 11 parts of desmodium, 15 parts of Herba Epimedii, 5 parts of turtle shell, 2 parts of Radix Paeoniae Alba, 5 parts of gynostemma pentaphylla, 7 parts of Rhizoma Chuanxiong, 10 parts of rhizoma imperatae, 5 parts of pueraria lobata, 11 parts of cassia twig, 8 parts of rhizoma atractylodis, 12 parts of coix seed, 11 parts of purslane.

Embodiment 8：

A kind of pharmaceutical composition for treating kidney stone of the present invention, takes following traditional Chinese medicine raw medicine：12 parts of eclipta, great burdock achene 10 parts, 2 parts of the membrane of a chicken's gizzard, 15 parts of wrinkled giant hyssop, 18 parts of setose thistle, 13 parts of Radix Notoginseng, 10 parts of Radix Glycyrrhizae, 22 parts of lophatherum gracile, 16 parts of spina date seed, Poria cocos 13 parts, 6 parts of cape jasmine, 8 parts of Asiatic plantain, 15 parts of corn stigma, 16 parts of honeysuckle, 8 parts of Lygodium japonicum, 14 parts of paniculate swallowwort, 6 parts of the fruit of Chinese wolfberry, 4 parts of corydalis tuber, 11 parts of dried orange peel, 15 parts of oldenlandia diffusa, 18 parts of ternip, 12 parts of desmodium, 15 parts of Herba Epimedii, 6 parts of turtle shell, in vain 4 parts of Chinese herbaceous peony, 11 parts of gynostemma pentaphylla, 8 parts of Rhizoma Chuanxiong, 15 parts of rhizoma imperatae, 6 parts of pueraria lobata, 20 parts of cassia twig, 10 parts of rhizoma atractylodis, 19 parts of coix seed, dent 17 parts of amaranth.

Embodiment 9：

A kind of pharmaceutical composition for treating kidney stone of the present invention, takes following traditional Chinese medicine raw medicine：18 parts of eclipta, great burdock achene 12 parts, 13 parts of the membrane of a chicken's gizzard, 18 parts of wrinkled giant hyssop, 23 parts of setose thistle, 15 parts of Radix Notoginseng, 11 parts of Radix Glycyrrhizae, 22 parts of lophatherum gracile, 18 parts of spina date seed, Fu 13 parts of Siberian cocklebur, 6 parts of cape jasmine, 9 parts of Asiatic plantain, 15 parts of corn stigma, 19 parts of honeysuckle, 8 parts of Lygodium japonicum, 15 parts of paniculate swallowwort, the fruit of Chinese wolfberry 8 Part, 3 parts of corydalis tuber, 15 parts of dried orange peel, 12 parts of oldenlandia diffusa, 19 parts of ternip, 19 parts of desmodium, 15 parts of Herba Epimedii, 8 parts of turtle shell, 5 parts of Radix Paeoniae Alba, 15 parts of gynostemma pentaphylla, 6 parts of Rhizoma Chuanxiong, 15 parts of rhizoma imperatae, 24 parts of pueraria lobata, 8 parts of cassia twig, 10 parts of rhizoma atractylodis, 17 parts of coix seed, horse 15 parts of bitterroot.

Wherein, the preparation method of the Chinese medicine composition is：

(1) each medicinal material of components by weight percent in any described pharmaceutical composition of each embodiment is taken, it is total to decoct dosing material for the first time 10-15 times of water boiling and extraction of weight decocts 1-2 hours：The 8-12 times of water measured of second of addition, decocts 1-1.2h, filters out Liquid is for use；The 8-12 times of water measured is added in third time, decocts 0.8-1.2h, it is for use to filter out liquid；Merge decocting liquid three times, filter, Filtrate is collected, relative density is the clear cream of 1.10-1.30 when being concentrated into 50-60 DEG C；

Acute toxicity test：

Take mouse 100,22-25 grams of weight is randomly divided into 10 groups, 1 group of 9 groups for the treatment of group and control group by weight：Treatment Group takes tablet prepared by 1-9 of the embodiment of the present invention respectively, and fasting presses 0.42ml/10g weight gastric infusions, dose after 12 hours 0.395g/ml, control group take distilled water, three times per day, give observation post administration 14 days, none is dead for mouse, and main organs have no It is abnormal, it also has no other apparent exceptions, puts to death within the 14th day simultaneously dissect some animals, visually observe main organs no abnormality seen.

Six months long term toxicity tests：It weighs weekly during administration primary, claims appetite daily, it is no dead or dying dynamic Object, as a result mouse hair color is bright and clean, and behavioral activity, glandular secretion, breathing, fecal character are normal.Pathologic finding prompts, to various Internal organs are without apparent drug-induced pathological change.

Clinical reasoning：

In order to verify the effect of pharmaceutical composition of the present invention, in November, -2016 in April, 2015 randomly selects kidney at outpatient service Calculus patient 500, patient age ranging from 21-62 Sui, average age is 43.5 ± 2.2 years old, wherein man 83, female 97； All patients are diagnosed as kidney stone through color ultrasound or abdomen plain film inspection, and calculus diameter is between 0.25~1.22cm, routine urinalysis inspection It the inspections such as looks into and makes a definite diagnosis that there are urinary system infection contaminations.Case is randomly divided into 10 groups, every group 50, wherein treatment group 1-9 groups, control group 1 group：Each group gender, age, course of disease etc. compare, difference there are no significant meaning (P>0.05) it, is comparable.

Diagnosis basis：

1.1 waists or upper abdomen continue dull pain or the violent angina of paroxysmal, are radiated to homonymy lower abdomen or vulva, angina hair There can be obstruction person that there can be renal shutdown simultaneously with cold sweat, vomiting, nausea, bilateral when making.

1.2 can have naked eyes or microscopic hematuria, hematuria aggravation when angina is broken out.

The most of visible calculus shades of 1.3X line urinary system plain films.

1.4 intravenous urography can further determine that whether calcification shadow is related with urinary system in plain abdominal radiograph, it may be determined that Position where calculus, whether there is or not obstructions, and can show x-ray radioparent calculus.

1.5 isotope kidney maps, B ultrasound, CT have certain help to diagnosis.

1.6 symptom：Symptoms include shiver with cold, fever, urgent urination, frequent micturition, odynuria, pain in the back, inability, blood urine, pyuria etc., chronic phase inflammation Or inflammation recurrent exerbation may occur in which edema, hypertension, albuminuria etc..Routine urianlysis：Specific gravity of urine increases or reduces, Urine proteins are positive Property, glucose in urine it is positive, microexamination finds that red blood cell is more than 3/HP, finds leucocyte and epithelial cell, cast etc..

Therapy：

Treatment group's 1-9 groups take granule prepared by 1-9 of the embodiment of the present invention respectively, take orally a 10mg, twice a day.

Control group takes the PAISHI KELI of Nanjing Tongrentang Pharmaceutical Co., Ltd., twice daily, 1 bag every time.

Each group treats the 2-3 course for the treatment of altogether with 10 days for 1 course for the treatment of.

Control group and control group are being taken medicine simultaneously, and daily amount of drinking water is increased, and average daily drink amount is 3000~5000ml, more It takes exercises, based on jumping or going upstairs movement, both hands intersect knocking rear waist in back side.

Criterion of therapeutical effect：

It cures：Clinical symptoms and sign disappear, calculus discharge, and color ultrasound or abdomen plain film show that uronephrosis disappears, calculus shade It disappears；

It improves：Clinical symptoms disappear, and calculus is moved down, reduces or is partly discharged, and uronephrosis disappears substantially；

In vain：Symptom is not improved, and calculus is unchanged without mobile or uronephrosis.

Effectively=healing+improvement

Efficacy result：

1 two groups of patient's effective percentage comparative analyses of table

Group	Number of cases	It cures	It improves	In vain	It is total effective
						Treatment group 1	50	39	11	0	50 (100%)
Treatment group 2	50	41	9	0	50 (100%)
						Treatment group 3	50	40	9	1	49 (98%)
Treatment group 4	50	42	8	0	50 (100%)
						Treatment group 5	50	40	10	0	50 (100%)
Treatment group 6	50	42	7	1	49 (98%)
						Treatment group 7	50	27	12	11	39 (78%)
Treatment group 8	50	25	13	12	38 (76%)
						Treatment group 9	50	29	12	9	41 (82%)
Control group	50	22	13	15	35 (70%)

1 result of table is shown：The drug of Chinese medicine composition embodiment 1-6 of the present invention for kidney stone patient outcomes most Good, for the prescription of embodiment 7-9 because of the composition transfers such as monarch drug in a prescription, ministerial drug, effect is slightly inferior, but is superior to comparative example.

Finally it should be noted that：The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although Present invention has been described in detail with reference to the aforementioned embodiments, it will be understood by those of ordinary skill in the art that：It still may be used With technical scheme described in the above embodiments is modified or equivalent replacement of some of the technical features； And these modifications or replacements, the range for various embodiments of the present invention technical solution that it does not separate the essence of the corresponding technical solution.

Claims

1. a kind of pharmaceutical composition for treating kidney stone, it is characterised in that：The bulk pharmaceutical chemicals of described pharmaceutical composition are by Radix Notoginseng, wild jujube Benevolence, corydalis tuber, setose thistle, Lygodium japonicum, desmodium, Asiatic plantain, honeysuckle, oldenlandia diffusa, eclipta, rhizoma imperatae, paniculate swallowwort, Fu Siberian cocklebur, lophatherum gracile, cape jasmine, corn stigma, purslane, the membrane of a chicken's gizzard, Radix Glycyrrhizae, Radix Paeoniae Alba, the fruit of Chinese wolfberry, dried orange peel, ternip, Herba Epimedii, Rhizoma Chuanxiong, Great burdock achene, turtle shell, pueraria lobata, rhizoma atractylodis, gynostemma pentaphylla, cassia twig, wrinkled giant hyssop, coix seed composition.

2. the pharmaceutical composition for the treatment of kidney stone according to claim 1, it is characterised in that：Described pharmaceutical composition is made Bulk pharmaceutical chemicals composition and parts by weight be：12-20 parts of eclipta, 10-16 parts of great burdock achene, 3-8 parts of the membrane of a chicken's gizzard, 5-12 parts of wrinkled giant hyssop, 12-17 parts of setose thistle, 7-12 parts of Radix Notoginseng, 4-9 parts of Radix Glycyrrhizae, 15-20 parts of lophatherum gracile, 10-15 parts of spina date seed, 8-12 parts of Poria cocos, cape jasmine 2-5 parts, 3-7 parts of Asiatic plantain, 11-14 parts of corn stigma, 9-15 parts of honeysuckle, 3-6 parts of Lygodium japonicum, 8-13 parts of paniculate swallowwort, the fruit of Chinese wolfberry 3-5 parts, 1-3 parts of corydalis tuber, 5-10 parts of dried orange peel, 5-10 parts of oldenlandia diffusa, 13-16 parts of ternip, 3-10 parts of desmodium, excessive sheep 8-13 parts of the leaves of pulse plants, 3-5 parts of turtle shell, 1-3 parts of Radix Paeoniae Alba, 5-10 parts of gynostemma pentaphylla, 3-6 parts of Rhizoma Chuanxiong, 8-13 parts of rhizoma imperatae, 3-5 parts of pueraria lobata, osmanthus 11-15 parts of branch, 4-8 parts of rhizoma atractylodis, 13-16 parts of coix seed, 11-14 parts of purslane.

3. the pharmaceutical composition for the treatment of kidney stone according to claim 1, it is characterised in that：Described pharmaceutical composition is made Bulk pharmaceutical chemicals composition and parts by weight be：12 parts of eclipta, 16 parts of great burdock achene, 3 parts of the membrane of a chicken's gizzard, 12 parts of wrinkled giant hyssop, 12 parts of setose thistle, three 7 10 parts, 9 parts of Radix Glycyrrhizae, 15 parts of lophatherum gracile, 15 parts of spina date seed, 8 parts of Poria cocos, 5 parts of cape jasmine, 3 parts of Asiatic plantain, 14 parts of corn stigma, gold 9 parts of honeysuckle flower, 6 parts of Lygodium japonicum, 8 parts of paniculate swallowwort, 5 parts of the fruit of Chinese wolfberry, 1 part of corydalis tuber, 10 parts of dried orange peel, 5 parts of oldenlandia diffusa, ternip 16 parts, 10 parts of desmodium, 8 parts of Herba Epimedii, 5 parts of turtle shell, 1 part of Radix Paeoniae Alba, 10 parts of gynostemma pentaphylla, 6 parts of Rhizoma Chuanxiong, 8 parts of rhizoma imperatae, pueraria lobata 3 Part, 15 parts of cassia twig, 4 parts of rhizoma atractylodis, 13 parts of coix seed, 14 parts of purslane.

4. the pharmaceutical composition for the treatment of kidney stone according to claim 1, it is characterised in that：Described pharmaceutical composition is made Bulk pharmaceutical chemicals composition and parts by weight be：20 parts of eclipta, 10 parts of great burdock achene, 8 parts of the membrane of a chicken's gizzard, 5 parts of wrinkled giant hyssop, 17 parts of setose thistle, three 7 12 parts, 4 parts of Radix Glycyrrhizae, 20 parts of lophatherum gracile, 10 parts of spina date seed, 12 parts of Poria cocos, 2 parts of cape jasmine, 7 parts of Asiatic plantain, 11 parts of corn stigma, gold 15 parts of honeysuckle flower, 3 parts of Lygodium japonicum, 13 parts of paniculate swallowwort, 3 parts of the fruit of Chinese wolfberry, 3 parts of corydalis tuber, 5 parts of dried orange peel, 10 parts of oldenlandia diffusa, white trailing plants 13 parts of fore-telling, 3 parts of desmodium, 13 parts of Herba Epimedii, 3 parts of turtle shell, 3 parts of Radix Paeoniae Alba, 5 parts of gynostemma pentaphylla, 4 parts of Rhizoma Chuanxiong, 10 parts of rhizoma imperatae, pueraria lobata 4 Part, 13 parts of cassia twig, 5 parts of rhizoma atractylodis, 16 parts of coix seed, 11 parts of purslane.

5. the pharmaceutical composition for the treatment of kidney stone according to claim 1, it is characterised in that：Described pharmaceutical composition is made Bulk pharmaceutical chemicals composition and parts by weight be：13 parts of eclipta, 11 parts of great burdock achene, 4 parts of the membrane of a chicken's gizzard, 6 parts of wrinkled giant hyssop, 13 parts of setose thistle, three 77 parts, 5 parts of Radix Glycyrrhizae, 18 parts of lophatherum gracile, 11 parts of spina date seed, 9 parts of Poria cocos, 4 parts of cape jasmine, 6 parts of Asiatic plantain, 12 parts of corn stigma, gold and silver Spend 13 parts, 4 parts of Lygodium japonicum, 9 parts of paniculate swallowwort, 4 parts of the fruit of Chinese wolfberry, 2 parts of corydalis tuber, 6 parts of dried orange peel, 6 parts of oldenlandia diffusa, ternip 14 Part, 5 parts of desmodium, 10 parts of Herba Epimedii, 4 parts of turtle shell, 2 parts of Radix Paeoniae Alba, 6 parts of gynostemma pentaphylla, 5 parts of Rhizoma Chuanxiong, 12 parts of rhizoma imperatae, 3 parts of pueraria lobata, 12 parts of cassia twig, 6 parts of rhizoma atractylodis, 14 parts of coix seed, 12 parts of purslane.

6. the pharmaceutical composition for the treatment of kidney stone according to claim 1, it is characterised in that：Described pharmaceutical composition is made Bulk pharmaceutical chemicals composition and parts by weight be：17 parts of eclipta, 15 parts of great burdock achene, 7 parts of the membrane of a chicken's gizzard, 11 parts of wrinkled giant hyssop, 16 parts of setose thistle, three 78 parts, 8 parts of Radix Glycyrrhizae, 16 parts of lophatherum gracile, 14 parts of spina date seed, 11 parts of Poria cocos, 3 parts of cape jasmine, 5 parts of Asiatic plantain, 13 parts of corn stigma, gold 14 parts of honeysuckle flower, 5 parts of Lygodium japonicum, 12 parts of paniculate swallowwort, 3 parts of the fruit of Chinese wolfberry, 1 part of corydalis tuber, 10 parts of dried orange peel, 9 parts of oldenlandia diffusa, white trailing plants 13 parts of fore-telling, 7 parts of desmodium, 11 parts of Herba Epimedii, 3 parts of turtle shell, 1 part of Radix Paeoniae Alba, 10 parts of gynostemma pentaphylla, 4 parts of Rhizoma Chuanxiong, 11 parts of rhizoma imperatae, pueraria lobata 4 parts, 14 parts of cassia twig, 7 parts of rhizoma atractylodis, 15 parts of coix seed, 13 parts of purslane.

7. the pharmaceutical composition for the treatment of kidney stone according to claim 1, it is characterised in that：Described pharmaceutical composition is made Bulk pharmaceutical chemicals composition and parts by weight be：15 parts of eclipta, 12 parts of great burdock achene, 5 parts of the membrane of a chicken's gizzard, 9 parts of wrinkled giant hyssop, 15 parts of setose thistle, three 79 parts, 7 parts of Radix Glycyrrhizae, 19 parts of lophatherum gracile, 13 parts of spina date seed, 10 parts of Poria cocos, 4 parts of cape jasmine, 4 parts of Asiatic plantain, 11 parts of corn stigma, gold 11 parts of honeysuckle flower, 5 parts of Lygodium japonicum, 10 parts of paniculate swallowwort, 5 parts of the fruit of Chinese wolfberry, 3 parts of corydalis tuber, 8 parts of dried orange peel, 8 parts of oldenlandia diffusa, ternip 14 parts, 9 parts of desmodium, 12 parts of Herba Epimedii, 5 parts of turtle shell, 3 parts of Radix Paeoniae Alba, 8 parts of gynostemma pentaphylla, 6 parts of Rhizoma Chuanxiong, 9 parts of rhizoma imperatae, pueraria lobata 5 Part, 12 parts of cassia twig, 7 parts of rhizoma atractylodis, 13 parts of coix seed, 11 parts of purslane.

8. the pharmaceutical composition for the treatment of kidney stone according to claim 1, it is characterised in that：Described pharmaceutical composition is made Bulk pharmaceutical chemicals composition and parts by weight be：19 parts of eclipta, 14 parts of great burdock achene, 6 parts of the membrane of a chicken's gizzard, 7 parts of wrinkled giant hyssop, 14 parts of setose thistle, three 79 parts, 6 parts of Radix Glycyrrhizae, 17 parts of lophatherum gracile, 13 parts of spina date seed, 10 parts of Poria cocos, 4 parts of cape jasmine, 4 parts of Asiatic plantain, 11 parts of corn stigma, gold 11 parts of honeysuckle flower, 5 parts of Lygodium japonicum, 10 parts of paniculate swallowwort, 5 parts of the fruit of Chinese wolfberry, 3 parts of corydalis tuber, 8 parts of dried orange peel, 8 parts of oldenlandia diffusa, ternip 14 parts, 4 parts of desmodium, 9 parts of Herba Epimedii, 5 parts of turtle shell, 3 parts of Radix Paeoniae Alba, 8 parts of gynostemma pentaphylla, 3 parts of Rhizoma Chuanxiong, 8 parts of rhizoma imperatae, 5 parts of pueraria lobata, 15 parts of cassia twig, 8 parts of rhizoma atractylodis, 16 parts of coix seed, 14 parts of purslane.

9. according to the pharmaceutical composition of any treatment kidney stones of claim 3-8, which is characterized in that the pharmaceutical composition Object uses following preparation steps：

(1) each medicinal material of components by weight percent in any described pharmaceutical compositions of claim 3-8 is taken, decocts dosing material gross weight for the first time 10-15 times of water boiling and extraction of amount decocts 1-2 hours：The 8-12 times of water measured of second of addition, decocts 1-1.2h, filters out medicine Liquid is for use；The 8-12 times of water measured is added in third time, decocts 0.8-1.2h, it is for use to filter out liquid；Merge decocting liquid three times, filter, receives Collect filtrate, relative density is the clear cream of 1.10-1.30 when being concentrated into 50-60 DEG C；

(2) clear cream made from step (1) is placed to room temperature, ethyl alcohol is added to make containing amount of alcohol to weight percent 60-75%, it is quiet It sets 24-48 hours, takes supernatant；Supernatant recycles ethyl alcohol, and relative density is 1.20-1.30's when being concentrated under reduced pressure into 50-60 DEG C Clear cream then centrifuges under the rotating speed of 3000r/min；In 60 DEG C of -80 DEG C of spray drying, dry extract is obtained；

(3) dry extract made from step (2) is put into micronizer and is crushed 1-2 hours, be sieved, obtain 100-200 purposes Suitable amount of sucrose, dextrin mixing is added in micropowders, and using ethyl alcohol as wetting agent, granulation is dry, and granule can be made in whole grain；Or Person will be put into micronizer after dry extract drying made from step (2) and crush 1-2 hours, is sieved, obtains 100-200 purposes Powder is made in micropowders；Or dry extract made from step (2) is put into micronizer and is crushed 1-2 hours, it is sieved, The micropowders of 100-200 mesh are obtained, appropriate superfine silica gel powder, α-galactolipin mixing is added and pelletizes using ethyl alcohol as wetting agent, does Dry, whole grain is encapsulated, and capsule is made；Or by dry extract made from step (2) be put into micronizer crush 1-2 it is small When, sieving obtains the micropowders of 100-200 mesh, suitable amount of sucrose, dextrin mixing is added, using ethyl alcohol as wetting agent, granulation is done Dry, tablet is made in whole grain, tabletting；Or suitable amount of sucrose, perfume (or spice) are added in the concentrate after the centrifugation obtained to above-mentioned steps (2) Essence mixing, sterilizing is filling, and liquid agent is made.

10. application of the pharmaceutical composition of the treatment kidney stone as described in claim 1-9 is any in treating kidney stone drug.