CN105497701A - Natural medicine for treating gout diseases and preparation method thereof - Google Patents

Abstract

The invention provides a natural medicine for treating gout diseases. The natural medicine is prepared from the following components in parts by weight: 45-55 parts of eurycoma longifolia jack extract, 60-70 parts of rhizoma smilacis glabrae extract, 25-30 parts of salvia miltiorrhiza extract, 45-65 parts of flemingia philippinensis extract, 25-45 parts of lophatherum gracile extract, 20-25 parts of astragalus glycosides, 25-35 parts of lalang grass rhizome extract, 30-65 parts of kudzu vine root extract, 30-35 parts of gynostemma pentaphylla extract, 20-40 parts of rhizoma alismatis extract, 25-30 parts of semen plantaginis extract and 40000-50000 parts of carrots. The medicine has the effects of strengthening kidneys and bones, expelling wind, eliminating dampness, removing spur, expelling cold and repairing chondrocytes, so that the effect of the medicine can quickly penetrate and reach the focus, 'rheumatism toxicity' in a human body or bone joints can be accurately cleaned, development of osteoarthritic joint inflammation can be stopped, an injured synovial membrane and synovial membranes can be repaired, and gout diseases can be radically treated.

Description

Natural drug for the treatment of gout disease and preparation method thereof

Technical field

The present invention relates to a kind of natural drug composition, be specifically related to a kind ofly treat natural drug of gout disease and preparation method thereof.

Background technology

Gout is a kind of ancient disease, and as far back as B.C. 5th century, western developed country just has the description about this disease, and to the 17th century, scientist just finds there is a kind of crystallization in tophus from microscope.Later from the blood of gout patients, subcutaneous tissue and articular cartilage deposit, find urate again.

Current gout is the trend of rejuvenation, and one is the dietary structure generation significant change of people, especially 20-40 year youngster diet in significantly increase containing high-energy, high purine substance person.Two is that overweight people increases.In patient with gout below 40 years old, the body weight for humans of about 85% is overweight.In addition, owing to the reason such as to be busy with one's work, in the gout crowd below 40 years old, majority's daily life is irregular, and physical exertion is fewer and feweri, and the person by bus that gos out increases, and by bike, pedestrian is gradually few.Serum uric acid level and Body Mass Index are proportionate.

In recent years, human body metabolic arthritis disease had been the healthy topic that middle-aged and elderly people is concerned about most.The display of the investigation for 300,000 retired persons of one, Nanjing, have old people's uric acid of 7.68% higher, the age is larger, and rate of falling ill is higher.More than China, the 4th height has also become the puzzlement of global people.European and American areas prevalence of hyperuricemia is 2%-18%.An investigation of Japan then shows, hyperuricemia nearly 20% is adult male.

Gout (gout) is long-term disorders of purine metabolism, blood uric acid increases the one group of disease causing tissue injury.Clinical characters is: hyperuricemia, acute arthritis recurrent exerbation, tophus are formed, chronic arthritis and joint deformity, and kidney urate calculus and gouty excess of the kidney matter pathological changes appear in the phase after being ill.

Uric acid is the product generated through oxidative metabolism by the purine base in human body, and purine is mainly high from (special medicated beer) content in the internal organs of our food, particularly animal, bone marrow and fish, shrimp, Eriocheir sinensis, chicken, duck, high nucleic acid health product, drinks.

Uric acid is the metabolic end product that in human body, purine nucleotides decomposes, and " rubbish " of human body, wherein three point two is discharged by urine, is discharged for three point one by feces.Purine nucleotides is originally the necessary a kind of element of human body, and the ratio of male and women is about 20: 1, and male accounts for 78.1% ~ 95%, and women only accounts for about 5%, and the group occurred frequently of male is middle-aged and elderly people, and women just there will be after menolipsis.This is because the estrogen in female body can suppress the generation of metabolic arthritis.In addition, male's the whirl of society, more than women, is often eaten meat, is drunk, particularly medicated beer, so male patient is in the majority.There is " funnel " that can hold 1200 milligrams of uric acid in human body, newly-generated 600 milligrams of every day, drain 600 milligrams simultaneously.But once " funnel " goes wrong, can not drain uric acid in time by kidney, uric acid will be brought in blood.When the uric acid concentration in blood exceedes normally, will be diagnosed as " hyperuricemia " clinically.If purine is too much in body, the uric acid generated is just many, no matter be that the interior uric acid manufactured of body is too much, or eliminating speed is obstructed, capital causes metabolic arthritis in blood, uric acid will be caused to be deposited in joint, cartilage and kidney with the form of sodium salt and to form crystallization, cause and organize foreign body inflammatory reaction, be i.e. gout.

Gout divides again gouty nephropathy, lithangiuria, acute obstructive nephropathy, tophus, acute arthritis, nephropathy, gouty nephropathy, persistence hyperuricemia, 20% has nephropathy to show clinically, through the several years or longer time can successively occur renal tubules and glomerule impaired, small part is developed to uremia.Research shows, the order of severity of urate nephropathy and gouty arthritis has nothing to do, and namely slight arthritis also can have nephropathy, and serious arthritis not necessarily has renal abnormality.

Lithangiuria; The urine of gout patients is in acid, and thus urine uric acid concentration increases, and less calculus is discharged with urine, but normal numbness, visible tiny brown sand grains in urinary sediment thing, larger calculus can be blocked ureter and cause hematuria and renal colic, because bradyuria secondary infection becomes pyelonephritis.Huge gallstone can cause the distortion of renal pelvis renal calices, hydronephrosis.

Acute obstructive nephropathy; See blood uric acid and urine uric acid obviously raises, that is because a large amount of uric acid crystal popularity is blocked caused by renal tubules.Gout is often with hypertension, hyperlipemia, arteriosclerosis, coronary heart disease and type 2 diabetes mellitus.In the gout cause of death, cardiovascular factor far exceedes renal insufficiency.But there is no direct causal connection between gout and cardiovascular disease, just both are all relevant with obesity, dietary factor.

Tophus; Also known as tophus, be that human body endogenous cause of ill blood uric acid excessively raises, exceed its saturation and health a part separate out white crystal.Gout patients, except central nervous system, all can form tophus in nearly all tissue.Tophus is most commonly in helix, also Duo Jian Yu Hallux toe Metatarsophalangeal joint, refer to, the place such as wrist, elbow and knee joint, a few patients can appear at nasal cartilages, tongue, vocal cords, eyelid, aorta, cardiac valve and cardiac muscle.

Acute arthritis; Psychentonia, overtired, take food high purine diet, joint injury, operation, infection etc. are for common inducement.With the first sole of the foot Zhi Ji Mu toe joint is common, be secondly other joint of ankle, hands, wrist, knee joint, elbow and foot.

Nephropathy; The primary gout patient of about 20% ~ 25% merges renal calculus, and wherein about 85% belongs to urate calculus.Renal colic, hematuria can be had when calculus is larger.The patient of 20% ~ 40% can have intermittent a small amount of albuminuria in early days.

It is the key reason that gout occurs that uric acid in blood increases for a long time, Uric Acid is mainly derived from two aspects: (1) human body cell internal protein catabolism produce nucleic acid and other purine compound, through some enzymes effect and generate endogenous uric acid; (2) contained in food purine compound, nucleic acid and nucleoprotein composition, after peptic ulcer bleeding, the effect through some enzymes generates exogenous uric acid.The generation of uric acid is a very complicated process, needs the participation of some enzymes.These enzymes are broadly divided into two classes: the enzyme promoting uric acid synthesis, are mainly 5-NAP-1-pyrophosphate synthetase, the acid of adenine phosphoric acid nucleoside transferring enzyme, phosphoribosylpyrophosphate amide transferase and xanthine oxidase; Suppress the enzyme of uric acid synthesis, mainly hypoxanthine-guanosine transferring enzyme.Gout is exactly because various factors causes the activity of these enzymes abnormal, such as, promote the increased activity of uric acid synzyme, suppress the reduced activity etc. of uric acid synzyme, thus cause uricopoiesis too much.Or cause kidney excretion uric acid generation obstacle due to various factors, uric acid is built up in blood, produces hyperuricemia.Hyperuricemia is as long-term existence, and uric acid will be deposited on the positions such as joint, subcutaneous tissue and kidney with uratic form, causes the series of clinical manifestations such as arthritis, subcutaneous gout calculus, kidney stone or gouty nephropathy.

Gout is Recurrent Acute or the chronic arthritis in joint, periphery, because the monosodium urate salt-pepper noise in supersaturation hyperuricemia body fluid is in joint, in tendon and around caused by deposition, patient with gout men and women disease rates is 20 to 1, the main cause that women's gout sickness rate is low is: women's body inner estrogen can promote urate excretion, and has the effect suppressing arthritis outbreak.

The harm of gout disease is as follows:

Due to uric acid excessive concentration in blood of human body, at soft tissue as formed acicular crystal in membrana articulata or tendon, cause body immune system overreaction and the inflammation that causes suffering.General outbreak position is thumb joint, ankle joint, knee joint etc.According to statistics, gout patients 20%-25% has urate nephropathy, and confirms through postmortem, and person is almost 100% nephropathy, and it comprises gouty nephropathy, acute obstructive nephropathy and lithangiuria.

Patient with gout main causes of death; Gout causes kidney damage lethal, and renal function suffers damage, and finally develops into renal failure and uremia is lethal, and this kind of situation accounts for about the 20%-30% of the gout cause of death.Only a few patient with gout blood uric acid when gout acute attack obviously raises, and can in a short time acute renal failure occur and cause death.

Two, because not taking remedy measures in time after the lethal tophus ulceration of skin infection, do not pay attention to sanitation and hygiene again, result causes antibacterial severe infections, spread in blood cause bacteremia and septicemia lethal, but this kind is very rare.

Three, the lethal gouty renal calculus of urinary tract infection or hydronephrosis, vesical calculus etc. cause intractable urinary system infection, especially cause pyelonephritis, and in time thoroughly treatment can cause pyonephrosis or necrotic renal papillitis, septicemia and lethal.

Some acute and chronic complication etc. that the some diseases that four, the lethal gout of complication is concurrent causes as hypertension, arteriosclerosis, coronary heart disease, cerebrovas-cularaccident, myocardial infarction, heart failure, mortality cardiac arrhythmia and diabetes, these concurrent diseases are major reasons of patient with gout death, occupy certain ratio in death.In older patient with gout (especially more than 55 years old), its main causes of death are for merging cardiovascular disease, instead of kidney disease.

Gout can be divided into four-stage clinically:

First stage is the metabolic arthritis disease phase, and patient, except blood uric acid raises, does not occur the clinical symptoms of gout;

Second stage is that gout is early stage, blood uric acid persistence increases, acute gouty arthritis is caused to break out, most people be in one's sleep as wake up with a start by the pain as lancinating, first place is often the halluces of foot, redness and swelling of joints, scorching hotly to swell, can not cover son, foot is stretched in outside, if there is slight wind blow over or slightly touch, activity is toe once, immediately pain must as unbearable, but in several days or several weeks, meeting disappears automatically, seems the inflammation in joint, symptom eliminates, the same with normal person.In fact the crystallization of uric acid does not disappear, and mistake-section can continue to do mischief, and joint becomes that swelling is stiff, joint stuffiness gradually;

Phase III is gout mid-term, toe joint when falling ill by just, gouty arthritis is acute attack repeatedly, several times after acute attack, feed through to the general joint such as finger, toe, wrist, ankle, knee joint gradually, and then soft tissue around and sclerotin also suffer destruction in various degree and dysfunction, uric acid crystal constantly deposits, and defines at leisure " tophus " that calculus is the same;

Fourth stage is late gout, and patient articular's deformity and dysfunction are day by day serious, and tophus increases, and volume increases, and easy ulceration flows out white urate crystal, joint permanent deformity.Urate constantly deposits in kidney, forms renal calculus etc., clinically occurs the impaired renal function evils such as edema, oliguria, albuminuria, nocturia increase, hypertension, anemia, and renal function obviously goes down, the renal failure not easily reversed and threat to life.

The chemicals that gout disease is commonly used at present has: the third semi-annular jade pendant relaxes (probenecid), the mechanism of action of uricosuric drug is suppress renal tubules absorbing again uric acid, increase uric acid to discharge from urine, thus the concentration of uric acid in minimizing blood, final minimizing urate deposition, in soft tissue, reduces the generation of gout inflammation.

Colchicine: for the medicine of analgesic agent and suppression uricopoiesis processes gout patients, curative effect is pretty good substantially, but the side effect of allergic constitution and gastrointestinal upset is rather common.

Benzbromarone (Benzbromarone): be benzofuran derivative, has and suppresses renal tubules thus to reduce uric acid concentration in blood to the resorption of uric acid.Oral easy absorption, its metabolite is for there being acting type, and in latter 24 hours blood of taking medicine, uric acid is 66.5% before taking medicine.

Conventional antiinflammatory chemicals: diclofenac sodium, has another name called two grams of chlorine fen sodium (DiclofenacSodium) non-steroidal anti-inflammatory analgesic 25mg every days two to three times after the meal, each one to two.

Celebrex (celecoxib): every day one to secondary after the meal, each 200mg.The general acute gout of antiinflammatory chemicals is taken.

If long-term taking, above-mentioned medicine easily allows patient occur gastroenteropathy, leukopenia, even liver function injury etc.Therefore be necessary that exploitation one can drain uric acid, suppress uric acid synthesis, again can reducing swelling and alleviating pain, and the new Chinese patent medicine that safety has no side effect.

Summary of the invention

An object of the present invention is to overcome the above-mentioned deficiency of prior art and provides a kind of natural drug for the treatment of gout disease, with strengthening kidney and tonifying bone, expelling wind and removing dampness, except thorn cold expelling, repair chondrocyte for theory, the effect of medicine is made to alter through focus fast, in accurate removing human body, " the numbness poison " of bone joint, blocking-up osteoarthritic inflammation develops, and repairs impaired synovial membrane and cartilage.Treatment gout disease natural drug breaks through the bottleneck that tradition is cured the symptoms, not the disease, can fundamentally for goat patient solves slight illness.

Two of object of the present invention is the preparation method providing above-mentioned treatment gout disease natural drug.

The present invention treats the natural drug of gout disease, with weight parts, comprises following composition:

Eurycoma longifolia extract product 45-55 part, Rhizoma Smilacis Glabrae extract 60-70 part, Radix Salviae Miltiorrhizae extract 25-30 part,

Hang horse pier extract 45-65 part, Herba Lophatheri extract 25-45 part, astragalosides 20-25 part,

Rhizoma Imperatae extract 25-35 part, Radix Puerariae extract 30-65 part, Herb Gynostemmae Pentaphylli extract 30-35 part,

Rhizoma Alismatis extract 20-40 part, Semen Plantaginis extract 25-30 part, Radix Dauci Sativae 40000-50000 part.

The present invention treats the natural drug of gout disease, can also add Herba Lysimachiae extract 15-25 part.

The present invention treats the natural drug of gout disease, can also add garlicin 15-25 part.

The present invention treats the natural drug of gout disease, can also add Formica fusca extract 25-30 part.

The present invention treats the natural drug of gout disease, can also add tartary buckwheat extract 100-120 part.

The preferred 45-50 part of wherein said Eurycoma longifolia extract product, purity is not less than 80%.

The preferred 20-23 part of wherein said astragalosides, purity is not less than 80%.

The preferred 20-25 part of wherein said garlicin, purity is not less than 95%.

Wherein said red square-bottomed bamboo basket is foretold for the bright red square-bottomed bamboo basket in northeast is foretold, preferred 40000-45000 part.

The preparation method for the treatment of gout disease natural drug of the present invention, in turn includes the following steps:

(1) beater is put in red square-bottomed bamboo basket fore-telling chopping and break into Radix Raphani slurry;

(2) treatment gout disease natural drug other composition used is calculated lots processed raw material weight by formula proportion, be positioned over to stir and hold in ware, add Radix Raphani slurry and stir, stir 20-30 minute;

(3) then add enhanced water mixing, deliver to extruder grain through transmission; The Mixing ratio by weight example of material and water is 10:(1-1.5);

(4) after prepared by finished granule, dried by finished granule, bake out temperature 70-80 degree, after dry, moisture is no more than 10%; Every 5g mono-bag packs, the qualified warehouse-in of the examination and test of products.Granularity size is adjustable.

The wherein moisture 15-20% of the middle mixed material of step (3), after adding enhanced water mixing, the dry wet standard of material is: use hand grip wet-milling, namely grab conglomeration, unclamp and do not fall apart, namely External Force Acting falls apart.Use hand grip wet-milling, grab and do not glue, pine and do not become loose.

Add enhanced water mixing in step (3) to make, appropriate stevioside can be dissolved regulate taste in water.

The present invention treats the instructions of taking of gout disease natural drug: every day 3 times, is total to 5-6.5g, 30 days courses for the treatment of at every turn.

The present invention treats the scope of application of gout disease natural drug: hyperuricemia, primary gout, secondary gout, heritability gout, gouty arthritis, rheumatoid arthritis, tophus, gouty nephropathy, acute obstructive nephropathy, uric acid renal calculus, gouty arthritis, gouty nephropathy, gouty renal calculus, gouty heart disease, gouty hypertension.

Kidney is " the congenital foundation ", and kidney has the functions such as store essential substances, main growth, growth, reproduction, the metabolism of main water liquid, and it is cause visceral dysfunction that deficiency of the kidney essence is damaged, and produces disease.Though gout disease pain is in joint, root is at blood, but also can say it is the problem of suffering from a deficiency of the kidney, because the filtering function of kidney reduces, the acid poison row in blood does not go out, and acid poison row do not go out, just the most easily accumulate in big toe joint, tip joint, thumb joint becomes crystallization, so long-term extruding joint, and deformity appears in joint.

The present invention treats the action principle of gout disease natural drug mainly: utilize distinctive bioactive molecule in composition to play the effect of two-way control enzyme, namely nucleic acid decomposition speed is controlled, suppress uric acid to synthesize and suppress the inflammatory reaction of the different in nature factor, improve the activity of uricolytic enzymes, promote dissolving and the excretion of uric acid; Secondly, the spontaneous recovery toxin expelling system of quick startup human body, participate in regulating human body " acid-base balance, in and blood uric acid ", conditioning the five internal organs balance, effectively promotes " metabolism of purine ", thorough correction purine metabolic disturbance, make purine metabolism recover physiological normal, thoroughly the uric acid crystal body of cleaning renal deposition, repairs damaged organ, swelling transference cure, blood uric acid is normal.

The present invention treats the using method of gout disease natural drug: every day 3 times, each 1 bag, and 40 minutes ante cibum, warm water was taken after mixing it with water, and product specification is 5g/ bag.

The present invention treats the Formica fusca extract in gout disease natural medicinal ingredients, garlicin, Radix Dauci Sativae slurry, Herba Lysimachiae, Rhizoma Imperatae, the Radix Astragali, hang the extracts such as Ma Dun, with strengthening kidney and tonifying bone, expelling wind and removing dampness, except thorn cold expelling, repair chondrocyte for theory, the effect of medicine is made to alter through focus fast, in accurate removing human body, " the numbness poison " of bone joint, blocking-up osteoarthritic inflammation develops, and repairs impaired synovial membrane and cartilage.Break through the bottleneck that tradition is cured the symptoms, not the disease, can fundamentally for goat patient solves slight illness.

Period 1, basis conditioning 15 days: Herb Gynostemmae Pentaphylli wherein, Rhizoma Alismatis extract, Semen Plantaginis, Radix Puerariae, penetrating power by Formica fusca formic acid, distinctive bioactive molecule, the purine metabolism in human body is regulated from positive and negative both direction, reverse purine, reach the quantity controlling purine synzyme, improve purine inhibitory enzyme activity.Reduce the synthesis of purine in body, after 15 days, pain, the symptom such as stiff, swollen, swollen are obviously alleviated, and uric acid declines, thus promotes the dissolving of uric acid, makes purine metabolism recover physiological normally, effectively controls metabolic arthritis.

Second round, nurse one's health 30 days mid-term: after the basis conditionings of 15 days, continue to take, comprehensive conditioning will be started to body, to patient articular, the uric acid micro-crystallization molecule of renal tract carries out softening dissolving, a part " neutralization is offset ", balance with plasma metabolism, uric acid micro-crystallization is reduced gradually, effective correction purine metabolic disturbance, regulate uric acid, the concentration of balance blood uric acid, alleviate and eliminate the inflammation of gout outbreak place, prevent from again forming calculus, make articular muscle capable of expansion and contraction, thus reach the object of curing gout, this step needs a course for the treatment of (30 days).

Period 3, the convalescent period of stablizing nurse one's health 90 days: the garlicin in compatibility, hang the pharmaceutical compositions such as Ma Dun, Rhizoma Imperatae, Semen Plantaginis, firmly the distinctive bioactive molecule of control had the effect of two-way control enzyme, suppress the inflammatory reaction of the different in nature factor, cleaning blood uric acid virulence factor, in body, uricopoiesis greatly reduces, uric acid in blood content recovers normal, joint, uric acid sodium salt micro-crystallization in body is softening rapidly to be dissolved, eliminate harmful enzyme in articular cavity, promote the excretion of uric acid, make purine metabolism recover physiological normal, tophus gradually deliquescing diminishes and disappears.This is the important prerequisite eliminating gout disease, and be also a crucial step, this step generally needs three courses for the treatment of (3 months).

Period 4, steadiness conditioning 2-4 the course for the treatment of (the 2-4 month): kidney has charge of the function such as growth promoter, reproduction, the metabolism of water liquid, improving inspiration by invigorating kidney-QI of human body.The Radix Astragali, Eurycoma longifolia extract product, nourishing the liver and kidney, repair impaired renal tissue, comprehensive and systematic enhancing immune function of human body, thorough correction purine metabolic disturbance, promote the dissolving of uric acid, thoroughly block inflammatory development, the acid discharge function of kidney is strengthened further, control atopen inflammatory and produce.Thus tophaceous deposition in effective removing the tissues and joints, thoroughly clear up the uric acid crystal body of renal deposition.Really complete rehabilitation gout disease on " disease " root.This step needs 2-4 the course for the treatment of (the 2-4 month).

General gout condition subject takes the present invention and treats and will entirely heal for gout disease natural drug granule 4-6 month.But crystallization appears in severe gout disease acid poison, joint deformity patient then needs just can thoroughly cure for 8-9 month.

The present invention treats gout disease natural drug main feature:

Feature one: green Chinese prescription, safe and effective, curative effect is thorough, without any side effects, is particularly suitable for that the course of disease is longer, the patient of aged debility takes.

Feature two: new therapeutic theory, auxiliaryly to control to support, and makes patient reach thorough healing truly.

Feature three: have and participate in Liver and kidney removing toxic substances, play antiinflammatory liver protection effect, stimulates bifidus bacillus in intestinal to increase, has good curative effect, have inhibitory action to the growth of malignant cell to gastric ulcer.

It is that one is directly oral that the present invention treats gout disease natural drug, is absorbed, does not injure liver, gallbladder, spleen, kidney, do not cause any burden to the intestines and stomach by stomach, and native granular complexing agent without any side effects, effective percentage is up to more than 95%.

Manufacture process is without chemistry and biochemical reaction, and product, not containing any chemical composition, after measured without any toxicity, does not produce the secondary impact of any poison to liver, kidney and other organs.

The primary raw material medicine that the present invention uses is described as follows:

(1) Eurycoma longifolia:

According to 2010 editions " Chinese Pharmacopoeias ", another name: the king of natural philter, the earth warrior, forest, control the medicine etc. of all kinds of diseases and ailments.Growing environment: be born in forest hillside place, be generally only distributed in tropical rainy country, original producton location Malaysia and Southeast Asian countries.[gathering processing]: medicinal, root bark, fruit and leaf.Using fresh herb or section are dried for subsequent use.Eurycoma longifolia can treat gout, prostatitis etc., can be anticancer.

(2) Herba Lysimachiae:

According to 2010 editions " Chinese Pharmacopoeias ", this product is the dry herb of Ofthe Primulaceae Lysimachia christinae Hance LysimachiachristinaeHance.Summer, Qiu Erji gather, and removing impurity, dries.The normal tangled mass of [character] this product, without hair or by thin pubescence.Stem distortion, the brown or dark brownish red in surface, have longitudinal grin, bottom stipes is had sometimes a fibrous root, section is solid.Leaf is to life, and many shrinkages are width egg shape or heart after flattening, long 1 ~ 4cm, wide 1 ~ 5cm, base portion nick, Quan Yuan; Upper surface celadon or sepia, following table complexion is more shallow, the obvious projection of master pulse, after water logging, to x ray fluoroscopy x visible black color or brown stripes; Long 1 ~ the 4cm of petiole.What have is wounded in the battle, brightly yellowish color, single leave axil, the long stalk of tool.Capsule is spherical.Feeble QI, lightly seasoned.[nature and flavor with return through] are sweet, salty, are slightly cold.Return liver, gallbladder, kidney, urinary bladder channel.[function with cure mainly] dampness removing jaundice eliminating, inducing diuresis for treating stranguria syndrome, removing toxic substances and promoting subsidence of swelling.For jaundice due to damp-heat, gallbladder-distention hypochondriac pain, stranguria caused by urinary stone, pyretic stranguria, difficulty and pain in micturition, carbuncle furuncle, snake bite and insect sting.

(3) Rhizoma Smilacis Glabrae:

According to 2010 editions " Chinese Pharmacopoeias ", it is the dry rhizome of liliaceous plant smilacis glabra SmilaxglabraRoxb..Summer, Qiu Erji excavate, removing fibrous root, cleaning, drying; Or take advantage of fresh-cut flakiness, dry.[character] this product is slightly cylindrical, slightly flat or in irregular stick, nodosity shape swells, the short branch of tool, long 5 ~ 22cm, diameter 2 ~ 5cm.Surface yellowish-brown or taupe, uneven, have hard fibrous root residue, there is circular bud trace on branch top, the existing irregular crackle of some crusts, and has residual scale leaf.Matter is hard.Section is Long Circle or irregular, thick l ~ 5mm, and edge is irregular; Tangent plane off-white color is extremely light red brown, mealiness, visible point-like vascular bundle and most sparklet; Matter is slightly tough, has dust from flying when fractureing, and has glutinous sliding sense after moistening with water.Feeble QI, taste is micro-sweet, puckery.[nature and flavor with return through] are sweet, light, flat.Return liver, stomach warp.[function with cure mainly] detoxify, dehumidifies, easing joint movement.For the limbs contracture caused by syphilis and mercurialism, bones and muscles pain; Damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula, scabies.

(4) Bulbus Allii:

According to 2010 editions " Chinese Pharmacopoeias ", this product is the bulb of liliaceous plant Bulbus Allii AlliumsativumL..Excavate when summer, leaf was withered, removing fibrous root and silt, ventilation dry in the sun is dry to crust.[character] this product is that class is spherical, diameter 3 ~ 6cm.Surface is by white, lavender or mauve film quality firecoat.Top is point slightly, and there is residual scape centre, and base portion has most mark of fibrous root.Peel off crust, visible solely head or 6 ~ 16 flap cloves, and be born in residual scape primitive period and enclose.Bulb lobe is slightly in oval, and crust film quality, tip is point slightly, and an arcuate eminence, peels off epithelium, white, meat.Gas is special, and acrid in the mouth is peppery, tool zest.[nature and flavor with return through] are pungent, temperature.Return spleen, stomach, lung meridian.[function with cure mainly] removing toxic substances and promoting subsidence of swelling, parasite killing, dysentery relieving.For carbuncle skin infection, scabies, pulmonary tuberculosis, pertussis, has loose bowels, dysentery.

(5) Radix Salviae Miltiorrhizae:

According to 2010 editions " Chinese Pharmacopoeias ", this product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae SalviamiltiorrhizaBge..Spring, Qiu Erji excavate, removing silt, dry.[character] this product rhizome is short and thick, and top is residual stem foot sometimes.Radical bar, elongated cylindrical, slightly bending, some branches tool must shape radiculas, long 10 ~ 20cm, diameter 0.3 ~ 1cm.Surface brownish red is to dark brownish red, and coarse, tool indulges wrinkle.Old root crust loosens, and shows purple brown, normal flake off more.Matter is hard and crisp, and section loosens, and have crack or slightly smooth and fine and close, skin zone's brownish red, woody part lark or puce, vessel cluster yellow-white, radially arranges.Feeble QI, mildly bitter flavor is puckery.Cultivation product are more sturdy, diameter 0.5-1.5CM.Surface red is brown, and the vertical wrinkle of tool, crust is close to incrust.Matter is solid, and section is more smooth, slightly in cutin sample.[nature and flavor with return through] are bitter, are slightly cold.GUIXIN, Liver Channel.[function with cure mainly] stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, { note of the ancient Chinese } abdominal mass is gathered, breast ventral spine pain, pyretic arthralgia pain, and skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.

(6) Ma Dun is hung:

According to 2010 editions " Chinese Pharmacopoeias ", [another name] golden pheasant lands, colour of loess chicken, rat tail, thoroughly Pheretima, Millettia Speciosa, winged steed, Niu Duntou, Glycine tomentella, colour of loess dusk, hang hitching post, very heavyly to hang, energetically yellow, thousand tails swing, three strands of silks, Taurus tail, a thousand pieces of golds pendants, Radix Flemingiae Philippinensis.[nature and flavor] are sweet; Puckery; Flat.[return through] lung; Kidney; Urinary bladder channel.[function cures mainly] expelling wind and removing dampness; Bone and muscle strengthening; Promoting blood circulation and detoxication.Main air pain of dampness syndrome; Lumbar muscle strain; Extremity flaccidity is soft; Traumatic injury; Laryngopharynx swelling and pain.

(7) Herba Lophatheri:

According to 2010 editions " Chinese Pharmacopoeias ", this product is the dry stem and leaf of grass Herba Lophatheri LophatherumgracileBrongn..Tap before not taking out spica summer, dry.Long 25 ~ the 75cm of [character] this product.Stem is cylindrical, has joint, surperficial pistac, section hollow.Sheath ftractures.Blade lanceolar, some shrinkages are curling, long 5 ~ 20cm, wide 1 ~ 3.5cm; Surface light green color or yellow green.Vein is parallel, and tool walks crosswise scun, and formed rectangular latticed, lower surface is particularly evident.Body is light, and matter is pliable and tough.Feeble QI, lightly seasoned.[meridian distribution of property and flavor] is sweet, light, cold.GUIXIN, stomach, small intestine meridian.[function with cure mainly] clearing away heat-fire, relieving restlessness is quenched the thirst, inducing diuresis for treating stranguria syndrome.For calentura excessive thirst, the puckery pain of oliguria with reddish urine, aphtha of the mouth and tongue.

(8) Radix Astragali:

According to 2010 editions " Chinese Pharmacopoeias ", this product is the dry root of leguminous plant Radix Astagali Astragalusmembranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Radix Astragali Astragalusmembranaceus (Fisch.) Bge..Spring, Qiu Erji excavate, and removing fibrous root and root head, dry.[nature and flavor] are sweet, temperature.[return through] returns lung, spleen channel.[function cures mainly] invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.

(9) Formica fusca:

According to 2010 editions " Chinese Pharmacopoeias ", this product is the adult dry body of ant insect bitooth multi-ant PolyrhachisdivesSmith.Caught before March November to next year, put in appropriate vessel and suffocate, take out dry, or scald rapidly dead with 60 DEG C of water, dry.[nature and flavor with return through] are salty, flat.Return liver, kidney channel.[function with cure mainly] the kidney invigorating is dispeled cold, nourishing the liver battalion muscle, eliminating blood stasis and smoothing collaterals.For rheumatoid arthritis, rheumatic arthritis, neurasthenia, chronic hepatitis etc.

(10): Rhizoma Imperatae:

According to 2010 editions " Chinese Pharmacopoeias ", [another name] cogonsatintail, Rhizoma Imperatae, Rhizoma Imperatae, root of couch grass [source] this product are the dry rhizome of grass Herba Imperatae ImperatacylindricaBeauv.var.major (Nees) C.E.Hubb..Spring, Qiu Erji excavate, and clean, dry, and removing fibrous root and film quality sheath, be bundled into wisp.[nature and flavor] are sweet, cold.[return through] returns lung, stomach, urinary bladder channel.[function cures mainly] cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema.

(11) Radix Puerariae:

According to 2010 editions " Chinese Pharmacopoeias ", this product is the dry root of legume pueraria lobata Puerarialobata (Willd.) ohwi.Practise and claim Herba Gelsemii Elegantis.Autumn, season in winter two excavate, and take advantage of fresh-cut and become sheet or fritter; Dry.[character] this product is rectangle sheet or the blockage of rip cutting, long 5 ~ 35cm, thick 0.5 ~ lcm.Crust light brown, has vertical wrinkle, coarse.Tangent plane yellow-white, texture is not obvious.Matter is tough, and fibroid is strong.Feeble QI, taste is micro-sweet.[nature and flavor with return through] are sweet, pungent, cool.Return spleen, stomach, lung meridian.[function with cure mainly] expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, rash, yang invigorating antidiarrheal, dredge the meridian passage, alcoholic intoxication.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels, dizziness and headache, apoplectic hemiplegia, obstruction of qi in the chest and cardialgia, damage of the spleen and stomach caused by alcoholism.

(12) Herb Gynostemmae Pentaphylli:

According to 2010 editions " Chinese Pharmacopoeias ", [another name] Herba Gynostemmatis, Herba Gynostemmatis, Herb Gynostemmae Pentaphylli, raw, Herba Gynostemmatis [source] the medical material Ji Yuan that lands: be the herb of cucurbitaceous plant Herb Gynostemmae Pentaphylli.Latin plant animal mineral name: Gynostemmapentaphyllum (Thunb.) Makino gathers and stores: the annual summer, can to gather 3-4 time in season in autumn two, cleans, dries.[nature and flavor] bitter in the mouth; Micro-sweet; Cool in nature.[return through] returns lung; Spleen; Kidney channel.[function cures mainly] heat clearing away; Tonify deficiency; Removing toxic substances.Main body void is weak; Nephrasthenia emission; Leukopenia; Hyperlipemia; Viral hepatitis; Chronic gastroenteritis; Chronic tracheitis.

(13) Rhizoma Alismatis:

According to 2010 editions " Chinese Pharmacopoeias ", this product is the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis Alismaorientalis (Sam.) Juzep..Excavate when winter, stem and leaf started withered, cleaning, drying, removing fibrous root and rough bark.[character] this product is spherical, the oval or oval of class, long 2 ~ 7cm, diameter 2 ~ 6cm.Surface yellow-white or fallow, have the mark of fibrous root of irregular transverse annular shallow ridges stricture of vagina and the tiny projection of majority, what bottom had has warty bud trace.Matter is solid, section yellow-white, and mealiness has most pore.Feeble QI, mildly bitter flavor.[meridian distribution of property and flavor] is sweet, light, cold.Return kidney, urinary bladder channel.[function with cure mainly] promoting diuresis to eliminate damp pathogen, expels the heat-evil, changes turbid blood fat reducing.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipemia.

(14) Semen Plantaginis:

According to 2010 editions " Chinese Pharmacopoeias ", this product is Plantaginaceae plant Herba Plantaginis.The dry mature seed of PlantagoasiaticaL or Plantago depressa Willd PlantagodepressssaWiltd..To gather when summer, autumn two season seed maturity fruit ear, dry, rub seed, removing impurity.[character] this product ovalize, irregular Long Circle or triangular shape Long Circle, slightly flat, be about 2mm, wide about 1mm.Surface yellowish-brown, to pitchy, has fine wrinkle, and one side has canescence concave point shape hilum, and matter is hard, and feeble QI is lightly seasoned.[decoction pieces]: meridian distribution of property and flavor is sweet, cold.Return liver, kidney, lung, small intestine meridian.[function with cure mainly]: clearing away heat and promoting diuresis is treating stranguria, eliminating dampness by diuresis antidiarrheal, and improving eyesight, eliminates the phlegm.For the puckery pain of pyretic stranguria, edema distension, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain.Phlegm-heat cough.

(15) Radix Dauci Sativae:

Radix Dauci Sativae is the one of Radix Raphani, is " Cruciferae Rhaphanus ", has another name called " large Radix Dauci Sativae ", " rouge radish " " northeast Radix Dauci Sativae ", one, biennial herb, root meat is spherical, root bark is red, root meat white.Originate in China, all there is cultivation various places, and northeast is the large Radix Dauci Sativae major production areas of China, because the factor such as weather and kind defines its high nutritive value and medical value.Radix Dauci Sativae slightly warm in nature, enters lung, stomach two warp, has the functions such as heat clearing away, removing toxic substances, dampness removing, dissipating blood stasis, invigorating the stomach and promoting digestion, preventing phlegm from forming and stopping coughing, pleasant, convenient, promoting the production of body fluid to quench thirst, invigorating middle warmer, settling five organs.

(16): Radix Et Rhizoma Fagopyri Tatarici:

Radix Et Rhizoma Fagopyri Tatarici is the medicine-food two-purpose crop that occurring in nature is very few, records according to Compendium of Material Medica: Radix Et Rhizoma Fagopyri Tatarici bitter in the mouth, and property is flat cold, the real the intestines and stomach of energy, physical strength profiting, continuous spirit, sharp knowledge, and refining the five internal organs slag is dirty; All on the books to Radix Et Rhizoma Fagopyri Tatarici in Thousand Golden Prescriptions, " Chinese medicine voluminous dictionary " and pertinent literature: can calm the nerves, wind pain is swollen in the wide intestinal of lively atmosphere blood, sending down the abnormal ascending QI, heat clearing away, long-pendingization of dispelling is stagnant, bowel relieving, intestine moistening, relieving constipation, cough-relieving, relieving asthma, antiinflammatory, antiallergic, heart tonifying, fat-reducing, the effect such as beauty treatment.Radix Et Rhizoma Fagopyri Tatarici and Radix Et Rhizoma Fagopyri Tatarici, formal name used at school hull buckwheat, another name buckwheat leaf seven, Radix Rhapontici buckwheat, Wan Nianqiao, spinach wheat, Wu Mai, Hua Qiao.

Detailed description of the invention

Below in conjunction with embodiment, embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting scope of the present invention.

The Example formulations that table 1 is pharmaceutical composition of the present invention.

In embodiment, the purity of Eurycoma longifolia extract product used is 80%, and garlicin purity used is 98%, and astragalosides purity used is 80%.

Table 1

The preparation method of above embodiment is as follows:

The first step: bright red for northeast square-bottomed bamboo basket is foretold chopping and put beater making beating, break into Radix Raphani slurry.

Second step: treatment gout disease natural drug other composition used is calculated lots processed raw material weight by formula proportion, is positioned over to stir and holds in ware, adds Radix Raphani slurry and stirs, stir 20 minutes.Add enhanced water mixing, material and water ratio mixed weight ratio 10:1 (material is 10, and water is 1), make the wet weight percentage ratio of mixed material be 15-20%.The dry wet standard of material is: use hand grip wet-milling, namely grab conglomeration, unclamp and do not fall apart, namely External Force Acting falls apart.Note: use hand grip wet-milling, grab and do not glue, pine and do not become loose.

3rd step: after adding enhanced water mixing, deliver to extruder grain through transmission, granularity size is (size is adjustable) as Semen setariae, namely completes mixed powder to finished granule preparation process.

4th step: after prepared by finished granule, dried by finished granule, bake out temperature is not higher than 80 degree, and after dry, moisture is no more than 10%, is carried out in accordance with regulations every 5g mono-bag and packs, the qualified warehouse-in of the examination and test of products.

Clinical Treatment Test one:

(1) patient

Choose 240 routine patients, the age was at 40 years old--and between 45 years old, check and examine as hyperuricemia, the gouty acute arthritis recurrent exerbation caused, symptom and the course of disease, without significant difference, are in ventilation mid-term stage, through treating with Western medicine gout, DeGrain.

Above 240 routine patients are divided into 12 groups at random, often organize 20 people, take the treatment gout disease natural drug of embodiment 1-12 respectively, every day 3 times, each 1 bag, every bag of 5g, 40 minutes ante cibum warm boiled water, within 30 days, be 1 course for the treatment of, take 6 courses for the treatment of, concrete outcome is in table 2.

(2) efficacy assessment standard:

Clinical cure: clinical symptoms and sign disappear, and lab testing uric acid, erythrocyte sedimentation rate, leukocyte and urine protein are normal.

Effective: clinical symptom disappearance, lab testing uric acid slightly increases, erythrocyte sedimentation rate, leukocyte and urine protein are normal.

Effective: clinical symptoms is obviously improved before comparatively treating, lab testing uric acid level declines obviously, erythrocyte sedimentation rate and leukocyte thereof

Higher.

Invalid: clinical symptoms and laboratory checking index are without change.

Table 2

Clinical Treatment Test two:

Gout disease patient 5 example, give the natural drug of the treatment gout disease that every patient prepares by the embodiment of the present invention 11 respectively, every day 3 times, each 1 bag, every bag of 5g, 40 minutes ante cibum, warm boiled water, 30 days was 1 course for the treatment of, took 6 courses for the treatment of.

Experimental result:

Gout disease: 5 routine patients, the age was at 20 years old--and between 45 years old, check and examine as hyperuricemia, the gouty acute arthritis recurrent exerbation caused.Suffered from gouty acute arthritis, rheumatoid factor false positive rate is high.Patient's palm refers to, toe, wrist, knee joint, elbow, ankle, shoulder and hip joint etc., and ankylosis becomes deformity, and knee joint, elbow, finger, wrist become fixing and bend position, finger becomes subluxation laterally, trick redness and swelling of joints has an intense pain, and two carpal joint red and swollen heat pains, lose self care ability.

Through treating with Western medicine gout, DeGrain.Use treatment gout disease natural drug granule of the present invention, after 15 days, effectively: symptom, sign disappear substantially, blood uric acid declines, and effectively control inflammation process, suppresses the inflammatory reaction to nonspecific factor, symptom fades away, and joint motion improves, pain relief.

After taking 30 days (1 month), treatment gout disease natural drug granule, comprehensive and systematic enhancing immune function of human body, regulates Liver and kidney metabolic function, nourishing kidney wind dispelling, blood circulation promoting and blood stasis dispelling, and reduce the quantity of sequestered uric acid in blood, inflammation is eliminated substantially.

After taking 4 course for the treatment of (4 months), treatment gout disease natural drug granule firmly has the effect of two-way control enzyme the distinctive bioactive molecule of control, control nucleic acid decomposition speed, suppress uric acid synthesis, suppress the inflammatory reaction of nonspecific factor, promote the excretion of uric acid, make purine metabolism recover physiological normal, swelling transference cure, blood uric acid is normal.

To take after 6 courses for the treatment of after (6 months), potassium in the northeast Radix Dauci Sativae slurry that treatment gout disease natural drug granule is exclusive, participate in regulating human body " acid-base balance, in and blood uric acid ", Radix Raphani thionin in the treatment gout disease natural drug granule of effective promotion " metabolism of purine ", the spontaneous recovery toxin expelling system of human body can be started fast, conditioning the five internal organs balance, thorough correction purine metabolic disturbance, promotes the dissolving of uric acid.What make the uric acid of in human body 75% is discharged by Liver and kidney, a small amount of by neutralization counteracting in body.Thus tophaceous deposition in effective removing the tissues and joints, thoroughly clear up the uric acid crystal body of renal deposition, " reparation damaged organ ", fundamentally cures gout.

5 routine patients, from then on no longer recur, effective percentage reaches more than 98%.

Claims (10)

1. treat a natural drug for gout disease, it is characterized in that with weight parts, comprise following composition: Eurycoma longifolia extract product 45-55 part, Rhizoma Smilacis Glabrae extract 60-70 part, Radix Salviae Miltiorrhizae extract 25-30 part, hangs horse pier extract 45-65 part, Herba Lophatheri extract 25-45 part, astragalosides 20-25 part, Rhizoma Imperatae extract 25-35 part, Radix Puerariae extract 30-65 part, Herb Gynostemmae Pentaphylli extract 30-35 part, Rhizoma Alismatis extract 20-40 part, Semen Plantaginis extract 25-30 part, Radix Dauci Sativae 40000-50000 part.

2. the natural drug for the treatment of gout disease according to claim 1, is characterized in that adding Herba Lysimachiae extract 15-25 part.

3. the natural drug for the treatment of gout disease according to claim 1, is characterized in that adding garlicin 15-25 part.

4. the natural drug for the treatment of gout disease according to claim 1, is characterized in that adding Formica fusca extract 25-30 part.

5. the natural drug for the treatment of gout disease according to claim 1, is characterized in that adding tartary buckwheat extract 100-120 part.

6. the natural drug for the treatment of gout disease according to claim 1, it is characterized in that described Eurycoma longifolia extract product is 45-50 part, purity is not less than 80%.

7. the natural drug for the treatment of gout disease according to claim 1, it is characterized in that described astragalosides is 20-23 part, purity is not less than 80%.

8. the natural drug for the treatment of gout disease according to claim 3, it is characterized in that described garlicin is 20-25 part, purity is not less than 95%.

9. the natural drug for the treatment of gout disease according to claim 1, it is characterized in that described red square-bottomed bamboo basket is foretold for the bright red square-bottomed bamboo basket in northeast is foretold, consumption is 40000-45000 part.

10. treat the preparation method of gout disease natural drug according to claim 1, it is characterized in that in turn including the following steps:

(1) beater is put in red square-bottomed bamboo basket fore-telling chopping and break into Radix Raphani slurry;

(2) treatment gout disease natural drug other composition used is calculated lots processed raw material weight by formula proportion, be positioned over to stir and hold in ware, add Radix Raphani slurry and stir, stir 20-30 minute;

(3) then add enhanced water mixing, deliver to extruder grain through transmission; The Mixing ratio by weight example of material and water is 10:(1-1.5);

(4) after prepared by finished granule, finished granule is dried, packaging.