CN104706856A - Traditional Chinese medicine for treatment of gout - Google Patents
Traditional Chinese medicine for treatment of gout Download PDFInfo
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- CN104706856A CN104706856A CN201510151096.6A CN201510151096A CN104706856A CN 104706856 A CN104706856 A CN 104706856A CN 201510151096 A CN201510151096 A CN 201510151096A CN 104706856 A CN104706856 A CN 104706856A
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Abstract
The invention relates to a traditional Chinese medicine for the treatment of gout, which is prepared from the following herbal materials in parts by weight: 24 parts of rhizoma ligustici wallichii, 24 parts of angelica sinensis, 18 parts of angelica pubescens, 18 parts of rhizoma alismatis, 18 parts of herba leonuri, 15 parts of pawpaws, 15 parts of clematis chinensis, 15 parts of cortex phellodendri, 5 parts of loofah sponge, and 10 parts of radix glycyrrhizae. Clinical experiments show that the traditional Chinese medicine disclosed by the invention can safely and effectively treat gout.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine being used for the treatment of gout.
Background technology
Gout is a kind of due to biosynthesis of purine metabolism increase, and uric acid produces too much or the uric acid rising in hyperamization because urate excretion is bad, and urate crystal is deposited on the repeated relapsing inflammatory diseases caused in synovium of joint, synovial bursa, cartilage and hetero-organization thereof.Normal merging with obesity, glucose-lipid metabolism disorder, hypertension, arteriosclerosis, coronary heart disease etc. occurs, long-term hyperuricemia, uric acid deposition can cause acute gouty arthritis recurrent exerbation; Chronic arthritis and joint deformity, function of joint is impaired; Cause renal calculus or gouty nephropathy, with the passing of time the course of disease can cause renal insufficiency, and finally can cause metabolism disorder, multi viscera is got involved, and has a strong impact on patient health status and life quality.There is no at present and carry out for the cause of disease medicine that effects a radical cure, Modern medical therapy usually uses oral suppression uric acid to synthesize or promotes urate excretion medicine, multiple organ injury is alleviated by reducing uric acid deposition, hepatic and renal function injure and myelosuppressive side effect can be there is in some patients, by clinical observation for many years, be intended to explore the advantage of Chinese medicine in primary disease treatment.Its Clinical symptoms is: hyperuricemia and urate crystal, characteristic acute arthritis, tophus, interstitial nephritis caused by deposition, and severe patient is shown in joint deformity and dysfunction, the uric acid lithangiuria of normal companion.
Medical material present Research involved in the present invention is as follows:
Rhizoma Chuanxiong [another name] rhizome of chuanxiong Qiong, Rhizoma Chuanxiong [source] this product are the dry rhizome of samphire Rhizoma Chuanxiong.Summer shows outstanding when joint dish on stem, and excavates during purplish, and removing silt, after shining, a heatable brick bed is done, then removes fibrous root.[nature and flavor] are pungent, temperature.[return through] returns liver, gallbladder, pericardium channel.[function cures mainly] blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.[usage and dosage] takes orally: decoct soup, 9 ~ 25g.[attention] hyperactivity of fire caused by deficiency of YIN, upper excess and lower deficiency and the weak people of gas avoid clothes.[extracts] " China's book on Chinese herbal medicine "
Radix Angelicae Sinensis [another name] is dry returns.[source] this product is the dry root of umbelliferae angelica.Autumn end excavates, and removing fibrous root and silt, after moisture slightly evaporates, be bundled into wisp, upper canopy, with pyrotechnics slowly smoke-dried beancurd.[nature and flavor] sweet, acrid, warm.[return through] returns liver, the heart, spleen channel.[function cures mainly] is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.[usage and dosage] takes orally: decoct soup, 10 ~ 25g.[attention] dampness fullness in the epigastrium and abdomen and the careful clothes of diarrhea with loose stool person.[extracts] " China's book on Chinese herbal medicine ".
Radix Angelicae Pubescentis [another name] fragrant Radix Angelicae Pubescentis, meat Radix Angelicae Pubescentis, RADIX ANGELICAE PUBESCENTIS from Sichuan of China, money mound Radix Angelicae Pubescentis.[source] this product is the dry root of samphire Angelica pubescens.Excavate when Seedling at the beginning of spring has just germinateed or autumn Mo, stem and leaf was withered, removing fibrous root and silt, be dried to half-dried, bank up 2 ~ 3 days, be dried to absolutely dry after feeling like jelly again.[nature and flavor] are pungent, bitter, tepor.[return through] returns kidney, urinary bladder channel.[function cures mainly] expelling wind and removing dampness, numbness relieving and pain relieving.For anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache.[usage and dosage] takes orally: decoct soup, 3-9g.The careful clothes of the dry person of [attention] deficiency of YIN blood.[extracts] " China's book on Chinese herbal medicine ".
Rhizoma Alismatis [another name] marshy land, Rhizoma Alismatis, car Herba Sonchi Oleracei, Saxidomus purpuratus, sky are bald, YIZHIHUA.[source] this product is the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis.Excavate when winter, stem and leaf started withered, cleaning, drying, removing fibrous root and rough bark.[nature and flavor] are sweet, cold.[return through] returns kidney, urinary bladder channel.[function cures mainly] diuresis, clearing away damp-heat.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia.[usage and dosage] takes orally: decoct soup, 6 ~ 9g.[attention] suffer from a deficiency of the kidney essence cunning person avoid clothes.[extracts] " China's book on Chinese herbal medicine ".
Herba Leonuri [another name] Herba Leonuri Artemisia, Herba Leonuri Chinese mugwort, Flos Carthami Chinese mugwort, Herba Leonuri, motherwort, triangle linseed, four stupefied sons.[source] this product is the fresh of labiate Herba Leonuri or dry aerial parts.Fresh goods Seedling Stage in spring is tapped to first summer flower early stage; Dry product stem and leaf in summer is luxuriant, Hua Weikai or tap when just opening, and dry, or cutting is dried.[nature and flavor] are bitter, pungent, are slightly cold.[return through] returns liver, pericardium channel.[function cures mainly] promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.[usage and dosage] takes orally: decoct soup, 9-30g.[attention] anemia of pregnant woman is forbidden.[extracts] " China's book on Chinese herbal medicine ".
Fructus Chaenomelis [another name] chaenomeles lagenaria, iron pin pear, wrinkled papaya, Fructus Chaenomelis.[source] this product is the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria.Summer, autumn two gather when season, fruit was greenish-yellow, and put in boiling water and scald to crust canescence, double vertical profile, dries.[nature and flavor] acid, temperature.[return through] returns liver, spleen channel.[function cures mainly] suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.For arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, convulsion of vomiting and diarrhoea, beriberi edema.[usage and dosage] takes orally: decoct soup, 6 ~ 9g.[attention] can not polyphagia, damages tooth and bone.Avoid lead, ferrum.[extracts] " China's book on Chinese herbal medicine ".
Radix Clematidis [another name] radix smilacis sieboldi, Radix Stemonae, Tacca chantrieri Andre, Herba Lespedezae Cuneatae [source] this product are the dry root and rhizome of ranunculaceae plant Radix Clematidis Clematis hexapetala (mountain knotweed) or northeast clematis (black common vetch).Autumn excavates, and removing silt, dries.[nature and flavor] are pungent, salty, temperature.[return through] returns urinary bladder channel.[function cures mainly] expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.For rheumatic arthralgia, numb limbs and tense tendons, the contracture of muscle arteries and veins, joint stuffiness, bone is choked with sobs larynx.[usage and dosage] takes orally: decoct soup, 6 ~ 9g.[attention] deficiency of vital energy blood is weak, and without wind-cold damp pathogen, person avoids clothes.[extracts] " China's book on Chinese herbal medicine ".
Cortex Phellodendri [another name] Cortex Phellodendri, Cortex Phellodendri, bark of a cork tree wood.[source] this product is the dry bark of rutaceae wampee or Cortex Phellodendri.The former practises title " Cortex Phellodendri ", and the latter practises title " Cortex Phellodendri ".After stripping bark, removing rough bark, dries.[nature and flavor] are bitter, cold.[return through] returns kidney, urinary bladder channel.[function cures mainly] heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.[usage and dosage] takes orally: decoct soup, 3 ~ 12g.[attention] diarrhea due to hypofunction of the spleen, the weak lack of appetite person of stomach avoids clothes.[extracts] " China's book on Chinese herbal medicine ".
Retinervus Luffae Fructus [another name] Fructus Luffae net, Fructus Luffae shell, melon network, wadding melon pulp, sky sieve line, vegetable sponge, chalina, Hypericum perforatum L..[source] this product is the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae.Summer, season in autumn two fruit maturation, peel turns yellow, inner withered time pluck, removing crust and sarcocarp, clean, dry, removing seed.[nature and flavor] are sweet, flat.[return through] returns lung, stomach, Liver Channel.[function cures mainly] dredging collateral, invigorates blood circulation, dispels the wind.For arthralgia pain contracture, distending pain in the chest and hypochondrium, galactostasis.[usage and dosage] takes orally: decoct soup, 4.5 ~ 9g.[extracts] " China's book on Chinese herbal medicine ".
Radix Glycyrrhizae [source] this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat., Glycyrrhiza glabra L..Spring, Qiu Erji excavate, and removing fibrous root, dries.[nature and flavor] are sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.[usage and dosage] takes orally: decoct soup, 1.5 ~ 10g.[attention] should not with Radix Euphorbiae Pekinensis, Flos Genkwa, Radix Kansui with using.[extracts] " China's book on Chinese herbal medicine ".
Summary of the invention
The present invention aims to provide a kind of Chinese medicine being used for the treatment of gout, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing gout.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of Chinese medicine being used for the treatment of gout, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Rhizoma Chuanxiong 24 parts, Radix Angelicae Sinensis 24 parts, Radix Angelicae Pubescentis 18 parts, Rhizoma Alismatis 18 parts, Herba Leonuri 18 parts, Fructus Chaenomelis 15 parts, Radix Clematidis 15 parts, Cortex Phellodendri 15 parts, Retinervus Luffae Fructus 5 parts, 10 parts, Radix Glycyrrhizae.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Outpatient service is collected and patient with gout 96 example of being in hospital altogether in inventor in October, 2012 ~ 2013 between year October, be divided into treatment group 56 example and matched group 40 example at random, treatment group man 53 example, female 3 example, 20 ~ 69 years old age, 43.5 years old mean age; Matched group man 38 example, female 2 example, 20 ~ 69 years old age, 48 years old mean age.2 groups of sexes, age and course of disease comparing difference not statistically significants, have comparability.
Diagnostic criteria
Diagnostic criteria according to the meeting of national gout clinical speciality: (1), arthralgia acute attack are the classical symptoms of acute gout.Seizure of disease is many after slight damage, hyperalimentation or relevant disease, is apt to occur in far-end of limb joint especially, and typical symptom is sent out in toes (podagra), also can cause renal colic because of urate calculi.Chronic gout is changed to feature with destructive joint.(2) skin symptom: the case of about 1/2, have urate deposition in subcutaneous, these tuberositys are called as tophus or tophus.Tophus often in white or pearl tuberosity (gout Margarita), betides the skin edge (as auricle) of free arc.The other characteristic symptom of tophus refers to (toe) joint white or yellow tuberosity.Skin urate deposition.Thunder egg is seen by thinning skin, and they may ulceration.The tophus of juxtra-articular has the trend occurring in groups or merge.Tophus produces after acute attack, painless.If skin ulceration, can discharge white Calx sample material, the carcinogenic mixture of microscopical examination showed pencil pin sample material, is accredited as Monosodium urate.
2, test method
2.1 Therapeutic Method
The capsule that the oral the present invention for the treatment of group obtains according to specific embodiment 3, every day 2 times.Two weeks courses for the treatment of.
The oral other purine of matched group, 0.4g ~ 0.6g every day, two weeks courses for the treatment of.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Clinic control: clinical symptom disappearance, in hematuria liquid, uric acid content is normal, normal renal function;
Effective: clinical symptom remission, joint is red, swollen, hot, pain disappears, and local is without any reaction, and movable as usual, Level of Serum Uric Acid is down to normal range, and renal function takes a turn for the better;
Effective: arthroncus is gone down, pain relief, Level of Serum Uric Acid declines, but does not reach normal range;
Invalid: after treating 2 weeks, clinical symptoms is without change, and joint is red, swollen, hot, pain symptom is not obvious, and activity is still influenced, and Level of Serum Uric Acid does not decline.
3.2 therapeutic outcomes are in table 1.
Table 1 liang group comparitive study
| Group | n | Clinic control | Effective | Effectively | Invalid | Total effective rate (%) | Serious adverse reaction example |
| Treatment group | 56 | 10 | 18 | 25 | 3 | 94.64% | 0 |
| Matched group | 40 | 5 | 12 | 13 | 10 | 75% | 0 |
Visible, the medicine that the present invention obtains can safe and effective treatment gout, has promotional value.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Take: Rhizoma Chuanxiong 24 grams, Radix Angelicae Sinensis 24 grams, Radix Angelicae Pubescentis 18 grams, Rhizoma Alismatis 18 grams, Herba Leonuri 18 grams, Fructus Chaenomelis 15 grams, Radix Clematidis 15 grams, Cortex Phellodendri 15 grams, Retinervus Luffae Fructus 5 grams, 10 grams, Radix Glycyrrhizae; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of gout.Oral, every bu is taken for twice sooner or later.
Embodiment 2
Take: Rhizoma Chuanxiong 24 grams, Radix Angelicae Sinensis 24 grams, Radix Angelicae Pubescentis 18 grams, Rhizoma Alismatis 18 grams, Herba Leonuri 18 grams, Fructus Chaenomelis 15 grams, Radix Clematidis 15 grams, Cortex Phellodendri 15 grams, Retinervus Luffae Fructus 5 grams, 10 grams, Radix Glycyrrhizae; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of gout.Oral, every bu is taken for twice sooner or later.
Embodiment 3
Take: Rhizoma Chuanxiong 24 grams, Radix Angelicae Sinensis 24 grams, Radix Angelicae Pubescentis 18 grams, Rhizoma Alismatis 18 grams, Herba Leonuri 18 grams, Fructus Chaenomelis 15 grams, Radix Clematidis 15 grams, Cortex Phellodendri 15 grams, Retinervus Luffae Fructus 5 grams, 10 grams, Radix Glycyrrhizae; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of gout.Oral, every bu is taken for twice sooner or later.
Claims (4)
1. one kind is used for the treatment of the Chinese medicine of gout, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Rhizoma Chuanxiong 24 parts, Radix Angelicae Sinensis 24 parts, Radix Angelicae Pubescentis 18 parts, Rhizoma Alismatis 18 parts, Herba Leonuri 18 parts, Fructus Chaenomelis 15 parts, Radix Clematidis 15 parts, Cortex Phellodendri 15 parts, Retinervus Luffae Fructus 5 parts, 10 parts, Radix Glycyrrhizae.
2. as claimed in claim 1 for the Chinese medicine of gout, it is characterized in that, its preparation method is: take: Rhizoma Chuanxiong 24 parts, Radix Angelicae Sinensis 24 parts, Radix Angelicae Pubescentis 18 parts, Rhizoma Alismatis 18 parts, Herba Leonuri 18 parts, Fructus Chaenomelis 15 parts, Radix Clematidis 15 parts, Cortex Phellodendri 15 parts, Retinervus Luffae Fructus 5 parts, 10 parts, Radix Glycyrrhizae; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 parts, obtains decoct; Above-mentioned part all refers to weight portion.
3. be used for the treatment of the Chinese medicine of gout as claimed in claim 1, it is characterized in that, its preparation method is: take: Rhizoma Chuanxiong 24 parts, Radix Angelicae Sinensis 24 parts, Radix Angelicae Pubescentis 18 parts, Rhizoma Alismatis 18 parts, Herba Leonuri 18 parts, Fructus Chaenomelis 15 parts, Radix Clematidis 15 parts, Cortex Phellodendri 15 parts, Retinervus Luffae Fructus 5 parts, 10 parts, Radix Glycyrrhizae; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight portion.
4. be used for the treatment of the Chinese medicine of gout as claimed in claim 1, it is characterized in that, its preparation method is: take: Rhizoma Chuanxiong 24 parts, Radix Angelicae Sinensis 24 parts, Radix Angelicae Pubescentis 18 parts, Rhizoma Alismatis 18 parts, Herba Leonuri 18 parts, Fructus Chaenomelis 15 parts, Radix Clematidis 15 parts, Cortex Phellodendri 15 parts, Retinervus Luffae Fructus 5 parts, 10 parts, Radix Glycyrrhizae; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, obtains capsule; Above-mentioned part all refers to weight portion.
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| CN201510151096.6A CN104706856A (en) | 2015-04-01 | 2015-04-01 | Traditional Chinese medicine for treatment of gout |
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| CN201510151096.6A CN104706856A (en) | 2015-04-01 | 2015-04-01 | Traditional Chinese medicine for treatment of gout |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106439A (en) * | 2015-09-30 | 2015-12-02 | 淄博夸克医药技术有限公司 | Traditional Chinese medicine for treating hiccup |
| WO2017101595A1 (en) * | 2015-12-14 | 2017-06-22 | 华坚 | Traditional chinese medicine composition for treating gout and preparation method therefor |
| CN107812075A (en) * | 2017-11-24 | 2018-03-20 | 郭涤尘 | A kind of capsule for treating gout |
-
2015
- 2015-04-01 CN CN201510151096.6A patent/CN104706856A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106439A (en) * | 2015-09-30 | 2015-12-02 | 淄博夸克医药技术有限公司 | Traditional Chinese medicine for treating hiccup |
| WO2017101595A1 (en) * | 2015-12-14 | 2017-06-22 | 华坚 | Traditional chinese medicine composition for treating gout and preparation method therefor |
| CN107812075A (en) * | 2017-11-24 | 2018-03-20 | 郭涤尘 | A kind of capsule for treating gout |
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Application publication date: 20150617 |
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