CN107823354A - A kind of Chinese medicine for being used to treat gout - Google Patents

Abstract

The present invention relates to a kind of Chinese medicine for being used to treat gout, it is prepared by the raw medicinal material of following weight proportion：24 parts of Ligusticum wallichii, 24 parts of Radix Angelicae Sinensis, 18 parts of levisticum, 18 parts of rhizoma alismatis, 18 parts of motherwort, 15 parts of pawpaw, 15 parts of the root of Chinese clematis, 15 parts of golden cypress, 5 parts of luffa, 10 parts of radix glycyrrhizae.Clinical experiments have proved that the present invention can safely and effectively treat gout.

Description

A kind of Chinese medicine for being used to treat gout

Technical field

The present invention relates to a kind of Chinese medicine, and in particular to a kind of Chinese medicine for being used to treat gout.

Background technology

Gout is a kind of because biosynthesis of purine is metabolized increase, and uric acid produces excessive or causes blood because uric acid excretion is bad Middle uric acid rise, urate crystal are deposited on caused repeated relapsing inflammatory in synovium of joint, synovial bursa, cartilage and its hetero-organization Disease.Often merge appearance with obesity, glucose -lipid metabolism disorder, hypertension, artery sclerosis, coronary heart disease etc., long-term hyperuricemia, Uric acid deposition can cause acute gouty arthritis recurrent exerbation；Chornic arthritis and joint deformity, function of joint are damaged；Cause With the passing of time kidney stone or gouty nephropathy, the course of disease can cause renal insufficiency, can finally cause metabolic disorder, multi viscera involvement, serious shadow Ring patient health status and life quality.The medicine effected a radical cure for the cause of disease is there is no at present, Modern medical therapy generally uses It is oral to suppress uric acid synthesis or promote uric acid excretion medicine, mitigate multiple organ injury, some patientss by reducing uric acid deposition The side effect of liver and kidney dysfunction and bone marrow suppression is may occur in which, passes through clinical observation for many years, it is intended to explores traditional Chinese medicine and is controlled in this disease Advantage in terms for the treatment of.Its Clinical symptoms is：Characteristic acute arthritis caused by hyperuricemia and urate crystal, deposition, Tophus, interstitial nephritis, severe patient see joint deformity and dysfunction, often with uric acid lithangiuria.

Medicinal material present Research involved in the present invention is as follows：

Ligusticum wallichii【Alias】Rhizome of chuanxiong Qiong, leaflet Ligusticum wallichii【Source】This product is the dry rhizome of samphire Ligusticum wallichii.Summer is when on stem The significant protrusion of disk is saved, and is excavated during purplish, removes silt, a heatable brick bed is done after solarization, then removes fibrous root.【Nature and flavor】It is pungent, temperature.【Channel tropism】 Return liver, courage, pericardium channel.【Major function】Blood-activating and qi-promoting, wind-expelling pain-stopping.For irregular menstruation, closed dysmenorrhea, abdominal mass stomachache, chest Coerce shouting pain, tumbling and swelling, headache, arthralgia pain due to rheumatism.【Usage and dosage】It is for oral administration：Decoct soup, 9~25g.【Pay attention to】It is fire excess from yin deficiency, upper Sheng Lower empty and weak gas people avoids clothes.【Take passages】《Chinese book on Chinese herbal medicine》

Radix Angelicae Sinensis【Alias】It is dry to return.【Source】This product is the dry root of umbelliferae angelica.Autumn Mo excavates, and removes fibrous root and mud Sand, after moisture slightly evaporates, it is bundled into wisp, upper canopy, with pyrotechnics slowly smoke-dried beancurd.【Nature and flavor】Sweet, acrid, warm.【Channel tropism】Return liver, the heart, The spleen channel.【Major function】Replenishing and activating blood, menstruction regulating and pain relieving, relax bowel.For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, Amenorrhea Dysmenorrhoea, asthenia cold abdominalgia, dry constipation of intestines, arthralgia pain due to rheumatism, injury from falling down, ulcer sores.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine invigorate blood circulation.For Amenorrhea pain Through, arthralgia pain due to rheumatism, injury from falling down.【Usage and dosage】It is for oral administration：Decoct soup, 10~25g.【Pay attention to】Full and diarrhea with loose stool person in dampness Careful clothes.【Take passages】《Chinese book on Chinese herbal medicine》.

Levisticum【Alias】Fragrant levisticum, meat levisticum, RADIX ANGELICAE PUBESCENTIS from Sichuan of China, money mound levisticum.【Source】This product is samphire weight peristome The dry root of Radix Angelicae Sinensis.Seedling at the beginning of spring is excavated when just germination or autumn end cauline leaf are withered, removes fibrous root and silt, is dried to half-dried, bank up 2~ 3 days, it is dried to again after feeling like jelly absolutely dry.【Nature and flavor】It is pungent, bitter, tepor.【Channel tropism】Return kidney, bladder warp.【Major function】Dispelling wind and eliminating dampness, Numbness relieving and pain relieving.For wind-cold-dampness arthralgia, lumbocrural pain, few the moon volt wind headache.【Usage and dosage】It is for oral administration：Decoct soup, 3-9g.【Pay attention to】 The careful clothes of the dry person of deficiency of Yin blood.【Take passages】《Chinese book on Chinese herbal medicine》.

Rhizoma alismatis【Alias】Marshy land, flower of complying with one's wishes, car bitter dish, day goose egg, day are bald, a flower.【Source】This product is planted for Alismataceae The dry tuber of thing rhizoma alismatis.Winter cauline leaf is excavated when starting withered, cleaning, drying, removes fibrous root and tertia.【Nature and flavor】It is sweet, tremble with fear. 【Channel tropism】Return kidney, bladder warp.【Major function】Diuresis, clearing away damp-heat.For difficult urination, oedema turgor, oliguria of having loose bowels, phlegm and retained fluid Dizziness, puckery pain of heat gonorrhea；High fat of blood.【Usage and dosage】It is for oral administration：Decoct soup, 6~9g.【Pay attention to】Kidney deficiency essence cunning person avoids clothes.【Take passages】 《Chinese book on Chinese herbal medicine》.

Motherwort【Alias】The female Chinese mugwort of the female wormwood artemisia of benefit, benefit, safflower Chinese mugwort, female grass, motherwort, triangle linseed, four stupefied sons.【Source】This Product are the fresh or dry aerial parts of labiate motherwort.Fresh goods spring Seedling Stage to first summer flower early stage taps；Dry product Tap, dry, or segment is dried when summer cauline leaf is luxuriant, Hua Weikai or first is opened.【Nature and flavor】It is bitter, pungent, it is slightly cold.【Channel tropism】Return Liver, pericardium channel.【Major function】Promoting blood circulation for regulating menstruation, inducing diuresis to remove edema.For irregular menstruation, dysmenorrhoea, Amenorrhea, lochiorrhagia, oedema urine It is few；Acute nephritis edema.【Usage and dosage】It is for oral administration：Decoct soup, 9-30g.【Pay attention to】Pregnant woman disables.【Take passages】《Chinese book on Chinese herbal medicine》.

Pawpaw【Alias】Chaenomeles lagenaria, iron pin pear, wrinkled papaya, Xuancheng's pawpaw.【Source】This product is rosaceous plant patch stalk The drying almost ripe fruit of Malus spectabilis.Summer, two season of autumn fruit it is greenish-yellow when harvest, put and scalded in boiling water to crust canescence, double of vertical profile, Dry.【Nature and flavor】Acid, temperature.【Channel tropism】Return liver, the spleen channel.【Major function】Soothing the liver relaxing muscles and tendons, stomach dampness elimination.For arthritis with fixed pain caused by dampness contraction, Waist and knee joint acid weight pain, convulsion of vomiting and diarrhoea, tinea pedis oedema.【Usage and dosage】It is for oral administration：Decoct soup, 6~9g.【Pay attention to】It can not eat more, Damage tooth and bone.Avoid lead, iron.【Take passages】《Chinese book on Chinese herbal medicine》.

The root of Chinese clematis【Alias】Radix smilacis sieboldi, hundred roots, LAOHUXU, cuneate lespedezas【Source】This product is ranunculaceae plant Wheeling Celestial Clematis hexapetala（Mountain knotweed）Or northeast clematis（Black common vetch）Drying root and rhizome.Autumn excavates, and removes silt, dries.【Property Taste】It is pungent, salty, temperature.【Channel tropism】Return bladder warp.【Major function】Dispelling wind and eliminating dampness, remove obstruction in channels to relieve pain.For arthralgia pain due to rheumatism, limbs fiber crops Wood, muscle arteries and veins contraction, joint stuffiness, bone are choked with sobs larynx.【Usage and dosage】It is for oral administration：Decoct soup, 6~9g.【Pay attention to】Deficiency of vital energy blood is weak, calm Cold-dampness heresy person avoids clothes.【Take passages】《Chinese book on Chinese herbal medicine》.

Golden cypress【Alias】Cork tree, first cypress, bark of a cork tree wood.【Source】This product is that rutaceae wampee or drying for cork tree are set Skin.The former practises title " CORTEX PHELLODENDRI CHINENSE ", and the latter, which practises, claims " CORTEX PHELLODENDRI AMURENE ".After stripping bark, tertia is removed, is dried.【Nature and flavor】Hardship, tremble with fear.【Return Through】Return kidney, bladder warp.【Major function】Heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice, under band, Heat gonorrhea, tinea pedis, impotence { are warded off }, hectic fever due to yin labor heat, night sweat, seminal emission, sore swollen toxin, eczema itch.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing Yin and falling fire.For the deficiency of Yin Hyperactivity of fire, night sweat hectic fever due to yin.【Usage and dosage】It is for oral administration：Decoct soup, 3~12g.【Pay attention to】Splenasthenic diarrhea, the weak deficiency of food person of stomach avoid clothes.【Take passages】 《Chinese book on Chinese herbal medicine》.

Luffa【Alias】Sponge gourd net, sponge gourd shell, melon network, wadding melon pulp, day sieve line, vegetable sponge, chalina, Hypericum perforatum L.【Come Source】This product is the vascular bundle of the dry mature fruit of cucurbitaceous plant sponge gourd.Summer, two season of autumn fruit maturation, pericarp turn yellow, are interior Portion is plucked when withered, removes crust and pulp, is cleaned, is dried, and removes seed.【Nature and flavor】It is sweet, put down.【Channel tropism】Return lung, stomach, liver Through.【Major function】Dredging collateral, promoting blood circulation, wind-dispelling.For numbness pain contraction, distending pain in the chest and hypochondrium, alactation.【Usage and dosage】It is for oral administration：Decoct Soup, 4.5~9g.【Take passages】《Chinese book on Chinese herbal medicine》.

Radix glycyrrhizae【Source】This product is glycyrrhizic legume, swollen fruit Radix, the dry root of glycyrrhiza glabra.Spring, the excavation of season in autumn two, Fibrous root is removed, is dried.【Nature and flavor】It is sweet, put down.【Channel tropism】The thoughts of returning home, lung, spleen, stomach.【Major function】Invigorate the spleen and benefit qi, heat-clearing solution Poison, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four Limb contraction urgency pain, carbuncle sore tumefacting virus, alleviate drug toxicity, strong.【Usage and dosage】It is for oral administration：Decoct soup, 1.5~10g.【Pay attention to】No Preferably with Beijing spurge root, lilac daphne, the root of gansui with use.【Take passages】《Chinese book on Chinese herbal medicine》.

The content of the invention

The present invention is intended to provide a kind of Chinese medicine for being used to treat gout, by selecting suitable medicinal material and its proportioning, reaches Safely and effectively cure the purpose of gout.

In order to achieve the above object, the present invention uses following technical scheme：

A kind of Chinese medicine for being used to treat gout, it is characterised in that it is prepared by the raw medicinal material of following weight proportion：River 24 parts of rhizome of chuanxiong, 24 parts of Radix Angelicae Sinensis, 18 parts of levisticum, 18 parts of rhizoma alismatis, 18 parts of motherwort, 15 parts of pawpaw, 15 parts of the root of Chinese clematis, golden cypress 15 part, thread 5 parts of melon network, 10 parts of radix glycyrrhizae.

The beneficial effects of the present invention will now be described with reference to clinical experimental data：

1st, general information

Outpatient service and in hospital patient with gout 96 are collected in inventor in October, 2012 ~ 2013 year altogether between October, are randomly divided into treatment group 56 and control group 40, treatment group man 53, female 3,20~69 years old age, average age 43.5 years old；Control group man 38, Female 2,20~69 years old age, average age 48 years old.2 groups of sexes, age and course of disease comparing difference are not statistically significant, and having can Compare property.

Diagnostic criteria

Diagnostic criteria according to national gout clinical speciality meeting：（1）, arthralgia acute attack be acute gout typical disease Shape.Seizure of disease is more after slight damage, hyperalimentation or relevant disease, is especially apt to occur in far-end of limb joint, typically Symptom is sent out in toes (podagra), also can cause renal colic because of urate calculi.Chronic gout is become with destructive joint turns to spy Sign.（2）Skin symptom：About 1/2 case, there is lithate to be deposited on subcutaneously, these tubercles are referred to as tophus or tophus. The normal white or pearl tubercle (gout pearl) of tophus, betide the skin edge (such as auricle) of free arc.Tophus Other characteristic symptom refers to the tubercle of (toe) joint white or yellow.Skin uric acid mineralization.Thunder egg can pass through change Thin skin sees that they may ulceration.The tophus of juxtra-articular has the trend for occurring in groups or merging.Tophus is in urgency Property breaking-out after produce, it is painless.If skin ulceration, white lime sample material, the cause of microscopical examination showed pencil needle-like material can release Cancer mixture, is accredited as Monosodium urate.

2nd, test method

2.1 treatment method

The oral present invention for the treatment of group is according to capsule made from specific embodiment 3,2 times a day.The course for the treatment of two weeks.

The oral other purine of control group, 0.4g ~ 0.6g is daily, the course for the treatment of two weeks.

3rd, criterion of therapeutical effect and treatment results

3.1 criterion of therapeutical effect

Clinic control：Clinical symptom disappearance, uric acid content is normal in blood urine liquid, normal renal function；

It is effective：Clinical symptom remission, joint is red, swollen, hot, pain disappears, and local without any reaction, activity is as usual, blood uric acid value drop To normal range (NR), renal function takes a turn for the better；

Effectively：Arthroncus is declined, pain relief, and blood uric acid value declines, but does not reach normal range (NR)；

It is invalid：After treating 2 weeks, clinical symptoms are without change, joint red, swollen, hot, pain symptoms unobvious, movable still impacted, blood urine Acid number does not decline.

3.2 treatment results are shown in Table 1.

1 two groups of curative effects of table compare

Group	n	Clinic control	It is effective	Effectively	It is invalid	Total effective rate (%)	Serious adverse reaction example
								Treatment group	56	10	18	25	3	94.64%	0
Control group	40	5	12	13	10	75%	0

It can be seen that medicine produced by the present invention can safely and effectively treat gout, there is promotional value.

Embodiment

In order to more fully understand and implement the present invention, the present invention is further illustrated with reference to specific embodiment.

Embodiment 1

Weigh：24 grams of Ligusticum wallichii, 24 grams of Radix Angelicae Sinensis, 18 grams of levisticum, 18 grams of rhizoma alismatis, 18 grams of motherwort, 15 grams of pawpaw, 15 grams of the root of Chinese clematis, 15 grams of golden cypress, 5 grams of luffa, 10 grams of radix glycyrrhizae；Add 8 times of amount water, decoct 1.5 hours, filtering；Filter residue adds 6 times of amount water, and it is small to decoct 1 When, filtering；Merging filtrate, 120 grams are concentrated into, produce the decoction for meeting one day dosage of normal adult.

For treating gout.Orally, taken twice sooner or later per bu.

Embodiment 2

Weigh：24 grams of Ligusticum wallichii, 24 grams of Radix Angelicae Sinensis, 18 grams of levisticum, 18 grams of rhizoma alismatis, 18 grams of motherwort, 15 grams of pawpaw, 15 grams of the root of Chinese clematis, 15 grams of golden cypress, 5 grams of luffa, 10 grams of radix glycyrrhizae；Add 10 times of amount water, decoct 2 hours, filtering；Filter residue adds 8 times of amount water, and it is small to decoct 1.5 When, filtering；Merging filtrate, concentrate, dry, packaging, produce the powder for meeting one day dosage of normal adult.

For treating gout.Orally, taken twice sooner or later per bu.

Embodiment 3

Weigh：24 grams of Ligusticum wallichii, 24 grams of Radix Angelicae Sinensis, 18 grams of levisticum, 18 grams of rhizoma alismatis, 18 grams of motherwort, 15 grams of pawpaw, 15 grams of the root of Chinese clematis, 15 grams of golden cypress, 5 grams of luffa, 10 grams of radix glycyrrhizae；Add 6 times of amount water, decoct 3 times, decoct 1 hour every time, merging decoction liquor, concentration, Dry, load capsule shells, produce the capsule for meeting one day dosage of normal adult.

For treating gout.Orally, taken twice sooner or later per bu.

Claims (4)

1. a kind of Chinese medicine for being used to treat gout, it is characterised in that it is prepared by the raw medicinal material of following weight proportion： 24 parts of Ligusticum wallichii, 24 parts of Radix Angelicae Sinensis, 18 parts of levisticum, 18 parts of rhizoma alismatis, 18 parts of motherwort, 15 parts of pawpaw, 15 parts of the root of Chinese clematis, 15 parts of golden cypress, 5 parts of luffa, 10 parts of radix glycyrrhizae.

2. it is used for the Chinese medicine of gout as claimed in claim 1, it is characterised in that its preparation method is：Weigh：24 parts of Ligusticum wallichii, 24 parts of Radix Angelicae Sinensis, 18 parts of levisticum, 18 parts of rhizoma alismatis, 18 parts of motherwort, 15 parts of pawpaw, 15 parts of the root of Chinese clematis, 15 parts of golden cypress, 5 parts of luffa, 10 parts of radix glycyrrhizae；Add 8 times of amount water, decoct 1.5 hours, filtering；Filter residue adds 6 times of amount water, decocts 1 hour, filtering；Merging filtrate is dense 120 parts are reduced to, produces decoction；Above-mentioned part each means parts by weight.

3. the as claimed in claim 1 Chinese medicine for being used to treat gout, it is characterised in that its preparation method is：Weigh：Ligusticum wallichii 24 Part, 24 parts of Radix Angelicae Sinensis, 18 parts of levisticum, 18 parts of rhizoma alismatis, 18 parts of motherwort, 15 parts of pawpaw, 15 parts of the root of Chinese clematis, 15 parts of golden cypress, luffa 5 Part, 10 parts of radix glycyrrhizae；Add 10 times of amount water, decoct 2 hours, filtering；Filter residue adds 8 times of amount water, decocts 1.5 hours, filtering；Merge filter Liquid, concentrate, dry, packaging, produce powder；Above-mentioned part each means parts by weight.

4. the as claimed in claim 1 Chinese medicine for being used to treat gout, it is characterised in that its preparation method is：Weigh：Ligusticum wallichii 24 Part, 24 parts of Radix Angelicae Sinensis, 18 parts of levisticum, 18 parts of rhizoma alismatis, 18 parts of motherwort, 15 parts of pawpaw, 15 parts of the root of Chinese clematis, 15 parts of golden cypress, luffa 5 Part, 10 parts of radix glycyrrhizae；Add 6 times of amount water, decoct 3 times, decoct 1 hour every time, merge decoction liquor, concentrate, dry, load capsule shells, Produce capsule；Above-mentioned part each means parts by weight.