CN103656355B - Medicine being used for the treatment of swine paratyphoid and preparation method thereof - Google Patents
Medicine being used for the treatment of swine paratyphoid and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of medicine being used for the treatment of swine paratyphoid and preparation method thereof, medicine comprises following crude drug: Radix Ophiopogonis, Radix Scutellariae, BAIMI, Flos Bombacis Malabarici, Herba Ephedrae, Fructus Artocarpi Heterophylli, Testa dolichoris, Fructus Arctii, Cortex Fraxini, Cortex Acanthopanacis Radicis, Herba Medicaginis, Semen setariae, Semen Arecae, Semen Coicis, Poria cum Radix Pini, Semen Phaseoli, Cortex Hibisci, Fructus Piperis, Tremella, Fructus Quisqualis, Moschus and Foliumet Ramulus Evodiae.The invention has the beneficial effects as follows: the present invention is Therapeutic Principle according to " strengthening vital QI to eliminate pathogenic factors, clearing away heat and nourishing YIN, anti-inflammatory and antalgic " to have evident in efficacy to the pig treatment suffering from paratyphoid fever, treating both the principal and secondary aspects of a disease, strengthening vital QI to eliminate pathogenic factors, cure rate is high, and toxic and side effects is little, not easily recur, the advantage that cost is low.
Description
Technical field
The present invention relates to herbal medicine technical field, particularly a kind of medicine being used for the treatment of swine paratyphoid and preparation method thereof.
Background technology
Swine paratyphoid (also known as porcine salmonellosis) is a kind of infectious disease being caused piglet by Salmonella bacteria.Acute person with septicemia, chronic person with necrotic enteritis, sometimes with Catarrhal or in cheese pneumonia for feature.Cause of disease is Salmonella choleraesuls and moscow' typhisuis mainly.Salmonella typhimurium, Dare also often cause primary disease in order to do Salmonella and Salmonella enteritidis etc.Salmonella is Gram-negative, the blunt circle in two ends, oval dialister bacterium, does not form brood cell, amphitrichous, can move.This bacterium has stronger resistance to the environmental factors such as drying, corruption, daylight, can survive in water 2 ~ 3 weeks, can survive in feces 1 ~ 2 month, can survive in freezing soil and pass the winter, though can only survive at damp warm place 4 ~ 6 weeks, the vigor of 8 ~ 20 weeks then can be kept in drying place.This bacterium is not strong to the resistance of heat, and 60 DEG C can be killed for 15 minutes.Also not strong to the resistance of various chemosterilant, routine disinfection medicine and typical concentrations thereof all can reach the object of sterilization.
Sick pig and the pig that carries disease germs are major source of infection, can from the fetus of excrement, urine, milk and miscarriage, afterbirth and amniotic fluid discharge of bacteria.Primary disease is mainly through digestive tract infection.Copulation or artificial insemination also can be infected.Also PI in uterus.According to another report, healthy poultry carries disease germs (particularly Salmonella typhimurium) quite generally, when affecting by extraneous undesirable element and animal resistance declines, often causes autogenous infection.Primary disease mainly encroaches on 6 monthly ages below piglet, especially with 1 ~ 4 the monthly age piglet multiple.6 the monthly age above piglet seldom fall ill.Primary disease all can occur throughout the year, but overcast and rainy wet season is multiple.
Primary disease incubation period is a couple of days, or reaches the several months, relevant with the quantity of pig body resistance and antibacterial, virulence.Divide acute, subacute and chronic three types clinically.Acute: also known as septic, the multiple piglet be born in before and after ablactation, normal sudden death.The course of disease is elder slightly, and performance body temperature raises (41 ~ 42 DEG C), and stomachache, dysentery, dyspnea, under the basal part of the ear, front and abdomen, skin has purpura, comes to an end mainly with death.The course of disease 1 ~ 4 day.Subacute and chronic type: be commonly encountered diseases type.Performance body temperature raises, and the inflammation of eye conjunctiva, has purulent secretion.Suffer from diarrhoea after first constipation, ash discharge white or yellow green stench feces.Sick pig becomes thin, and skin has crust shape eczema.The course of disease continues to reach several weeks, and end is to death or become cad pig.Acute: acute is changed to feature with septicemia.Corpse fat degree is normal, and portion's skins such as ear, abdomen, the side of body are visible congestion or hemorrhage sometimes, and have jaundice.Whole body serous coat, (larynx, bladder etc.) mucosa have ecchymosis.Splenomegaly, hard like rubber, tangent plane is bluish violet.The enlargement of mesenteric lymph node strand, the also enlargement in various degree of other lymph nodes of whole body, tangent plane is marble sample.Liver, renomegaly, hyperemia and hemorrhage, gastrointestinal mucosa catarrhal inflammation.Subacute type and chronic type: take necrotic enteritis as feature, common caecum, colon, involve ileum back segment sometimes.Intestinal mucosa is covered with the rotten milk of one deck lark, peels off by force, expose the ulcer surface that redness, edge are not whole.As mucosa around folliculus is downright bad, the concentric colyliform ulcer surface of normal formation.Mesenteric lymph strand swells, some caseous necrosises.Spleen is enlargement slightly, and liver has visible lark necrosis region.Sometimes lung generation chronic catarrhal inflammation, and have yellow cheesy tuberosity.
The treatment of current swine paratyphoid disease adopts more: oxytetracycline is oral, every day every kg body weight 50-100 milligram, point 2-3 time is oral, or every kg body weight 40 milligrams, 1 intramuscular injection; Or neomycin is oral, dosage is every kg body weight 40-50 milligram everyday, and point 2-3 time oral.
The shortcoming of Western medicine is that side effect is relatively large, is not suitable for long-term taking, and be also not suitable for uses as health medicine more, and some medicines easily produce drug resistance or Drug resistance.And Chinese medicine has no side effect, without Drug resistance, its role is to, the QI and blood of conditioning human body, smooth the liver and regulate the spleen, the metabolic function of adjustment body and immunologic function, have antivirus action again, therefore body recovery is fast, more do not recur after, with herbal control swine paratyphoid be in recent years many veterinarian concentrate one's attention on study problem.
The Chinese medicine developed at present is good not as Western medicine to the treatment curative effect of swine paratyphoid, therefore has report Western medicine and Chinese medicine composition to be used, though it has the advantage of relative low price, effective speed is comparatively slow, just can make transference cure when medicine time is longer.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of medicine being used for the treatment of swine paratyphoid, the various defects of Chinese medicine of the prior art and Western medicine can be overcome, have evident in efficacy to the piglet treatment suffering from primary disease, treating both the principal and secondary aspects of a disease, strengthening vital QI to eliminate pathogenic factors, cure rate is high, and toxic and side effects is little, not easily recur, the advantage that cost is low.
In order to realize foregoing invention object, the invention provides a kind of medicine being used for the treatment of swine paratyphoid, described medicine comprises following crude drug: Radix Ophiopogonis, Radix Scutellariae, BAIMI, Flos Bombacis Malabarici, Herba Ephedrae, Fructus Artocarpi Heterophylli, Testa dolichoris, Fructus Arctii, Cortex Fraxini, Cortex Acanthopanacis Radicis, Herba Medicaginis, Semen setariae, Semen Arecae, Semen Coicis, Poria cum Radix Pini, Semen Phaseoli, Cortex Hibisci, Fructus Piperis, Tremella, Fructus Quisqualis, Moschus and Foliumet Ramulus Evodiae.
Described medicine is made up of the crude drug of following ratio of weight and number: Radix Ophiopogonis 10-30 weight portion, Radix Scutellariae 10-20 weight portion, BAIMI 15-30 weight portion, Flos Bombacis Malabarici 10-20 weight portion, Herba Ephedrae 10-15 weight portion, Fructus Artocarpi Heterophylli 10-20 weight portion, Testa dolichoris 10-20 weight portion, Fructus Arctii 10-20 weight portion, Cortex Fraxini 15-30 weight portion, Cortex Acanthopanacis Radicis 15-30 weight portion, Herba Medicaginis 15-25 weight portion, Semen setariae 10-30 weight portion, Semen Arecae 10-20 weight portion, Semen Coicis 10-30 weight portion, Poria cum Radix Pini 10-20 weight portion, Semen Phaseoli 10-20 weight portion, Cortex Hibisci 10-20 weight portion, Fructus Piperis 10-20 weight portion, Tremella 10-20 weight portion, Fructus Quisqualis 10-20 weight portion, Moschus 10-25 weight portion and Foliumet Ramulus Evodiae 15-25 weight portion.
Described medicine is preferably made up of the crude drug of following ratio of weight and number: Radix Ophiopogonis 21 weight portion, Radix Scutellariae 15 weight portion, BAIMI 21 weight portion, Flos Bombacis Malabarici 15 weight portion, Herba Ephedrae 13 weight portion, Fructus Artocarpi Heterophylli 15 weight portion, Testa dolichoris 15 weight portion, Fructus Arctii 15 weight portion, Cortex Fraxini 23 weight portion, Cortex Acanthopanacis Radicis 22 weight portion, Herba Medicaginis 20 weight portion, Semen setariae 20 weight portion, Semen Arecae 15 weight portion, Semen Coicis 20 weight portion, Poria cum Radix Pini 15 weight portion, Semen Phaseoli 15 weight portion, Cortex Hibisci 15 weight portion, Fructus Piperis 13 weight portion, Tremella 15 weight portion, Fructus Quisqualis 13 weight portion, Moschus 17 weight portion and Foliumet Ramulus Evodiae 21 weight portion.
Described medicine also comprises: Pericarpium Citri Reticulatae, Ganoderma, Bulbus Allii, Fructus Jujubae and Fructus Crataegi.
Described medicine is made up of the crude drug of following ratio of weight and number: Radix Ophiopogonis 10-30 weight portion, Radix Scutellariae 10-20 weight portion, BAIMI 15-30 weight portion, Flos Bombacis Malabarici 10-20 weight portion, Herba Ephedrae 10-15 weight portion, Fructus Artocarpi Heterophylli 10-20 weight portion, Testa dolichoris 10-20 weight portion, Fructus Arctii 10-20 weight portion, Cortex Fraxini 15-30 weight portion, Cortex Acanthopanacis Radicis 15-30 weight portion, Herba Medicaginis 15-25 weight portion, Semen setariae 10-30 weight portion, Semen Arecae 10-20 weight portion, Semen Coicis 10-30 weight portion, Poria cum Radix Pini 10-20 weight portion, Semen Phaseoli 10-20 weight portion, Cortex Hibisci 10-20 weight portion, Fructus Piperis 10-20 weight portion, Tremella 10-20 weight portion, Fructus Quisqualis 10-20 weight portion, Moschus 10-25 weight portion, Foliumet Ramulus Evodiae 15-25 weight portion, Pericarpium Citri Reticulatae 15-30 weight portion, Ganoderma 15-25 weight portion, Bulbus Allii 10-15 weight portion, Fructus Jujubae 15-35 weight portion and Fructus Crataegi 15-25 weight portion.
Described medicine is preferably made up of the crude drug of following ratio of weight and number: Radix Ophiopogonis 15-25 weight portion, Radix Scutellariae 15-20 weight portion, BAIMI 20-30 weight portion, Flos Bombacis Malabarici 10-15 weight portion, Herba Ephedrae 10-15 weight portion, Fructus Artocarpi Heterophylli 12-18 weight portion, Testa dolichoris 12-19 weight portion, Fructus Arctii 10-20 weight portion, Cortex Fraxini 19-30 weight portion, Cortex Acanthopanacis Radicis 19-30 weight portion, Herba Medicaginis 15-20 weight portion, Semen setariae 15-25 weight portion, Semen Arecae 10-20 weight portion, Semen Coicis 15-25 weight portion, Poria cum Radix Pini 10-20 weight portion, Semen Phaseoli 13-18 weight portion, Cortex Hibisci 12-19 weight portion, Fructus Piperis 13-15 weight portion, Tremella 10-14 weight portion, Fructus Quisqualis 13-20 weight portion, Moschus 10-20 weight portion, Foliumet Ramulus Evodiae 15-20 weight portion, Pericarpium Citri Reticulatae 20-25 weight portion, Ganoderma 20-25 weight portion, Bulbus Allii 10-13 weight portion, Fructus Jujubae 20-30 weight portion and Fructus Crataegi 15-20 weight portion.
Described medicine is preferably made up of the crude drug of following ratio of weight and number: Radix Ophiopogonis 20 weight portion, Radix Scutellariae 19 weight portion, BAIMI 25 weight portion, Flos Bombacis Malabarici 13 weight portion, Herba Ephedrae 12 weight portion, Fructus Artocarpi Heterophylli 15 weight portion, Testa dolichoris 16 weight portion, Fructus Arctii 15 weight portion, Cortex Fraxini 25 weight portion, Cortex Acanthopanacis Radicis 24 weight portion, Herba Medicaginis 17 weight portion, Semen setariae 20 weight portion, Semen Arecae 15 weight portion, Semen Coicis 20 weight portion, Poria cum Radix Pini 15 weight portion, Semen Phaseoli 16 weight portion, Cortex Hibisci 15 weight portion, Fructus Piperis 14 weight portion, Tremella 12 weight portion, Fructus Quisqualis 15 weight portion, Moschus 12 weight portion, Foliumet Ramulus Evodiae 17 weight portion, Pericarpium Citri Reticulatae 23 weight portion, Ganoderma 24 weight portion, Bulbus Allii 12 weight portion, Fructus Jujubae 25 weight portion and Fructus Crataegi 18 weight portion.
In order to better realize foregoing invention object, present invention also offers a kind of preparation method being used for the treatment of the medicine of swine paratyphoid, described preparation method comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials, after mixing, be ground into powder; Added by powder in cold water and soak 24 hours ~ 36 hours, with slow fire boiling, decocting time is 2 hours ~ 3 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 3 ~ 5 times of the powder quality that the first step obtains;
Second step, the first step is filtered the filtering residue obtained again add in cold water, with slow fire boiling 2 ~ 4 times, each to decoct 1 hour ~ 2 hours, filter and merge filtrate, obtaining the second filtrate, the quality of the water added and identical in the first step;
3rd step, the first filtrate and the second filtrate merged, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, ensure that inlet temperature is at 160 DEG C ~ 170 DEG C, leaving air temp 50 DEG C ~ 70 DEG C, be ground into 200 order ~ 400 orders subsequently, obtain drug powder.
The beneficial effect that technical scheme provided by the invention is brought is: the present invention is Therapeutic Principle according to " strengthening vital QI to eliminate pathogenic factors, clearing away heat and nourishing YIN, anti-inflammatory and antalgic ", have evident in efficacy to the pig treatment suffering from paratyphoid fever, treating both the principal and secondary aspects of a disease, strengthening vital QI to eliminate pathogenic factors, cure rate is high, toxic and side effects is little, not easily recurs, the advantage that cost is low.
Detailed description of the invention
Chinese veterinarian think swine paratyphoid disease belong to damp and hot caused by, damp and hotly outer to attack or from interior life, damp and hotly to fight mutually, delay three burnt, gasification is obstructed, water channel is not smooth, and body internal organs healthy energy can not be fluent, and anti-heresy is unable, causes heating not smooth, tired mind, fever subsiding after perspiration, then re-heat, touching difficulty more, becomes typhoid fever; Damp and hotly fumigate in interior, can cause the enlargement of the internal organs such as spleen, liver congestion, serous coat is hemorrhage, the inflammation of intestinal ulcer, foul strongly fragrant corruption; Invade outside damp and hot removing toxic substances, the multiple speckle of visible skin surface is hemorrhage or form crust sample eczema.Primary disease with " strengthening vital QI to eliminate pathogenic factors, clearing away heat and nourishing YIN and anti-inflammatory and antalgic " for Therapeutic Principle, should improve the immunity of pig.According to above-mentioned theory and principle, the invention provides a kind of medicine being used for the treatment of swine paratyphoid, comprise following raw medicinal material: Radix Ophiopogonis, Radix Scutellariae, BAIMI, Flos Bombacis Malabarici, Herba Ephedrae, Fructus Artocarpi Heterophylli, Testa dolichoris, Fructus Arctii, Cortex Fraxini, Cortex Acanthopanacis Radicis, Herba Medicaginis, Semen setariae, Semen Arecae, Semen Coicis, Poria cum Radix Pini, Semen Phaseoli, Cortex Hibisci, Fructus Piperis, Tremella, Fructus Quisqualis, Moschus and Foliumet Ramulus Evodiae.
The pharmacological property of each crude drug is as follows:
Radix Ophiopogonis: sweet; Micro-hardship; Cold.Cure mainly: nourishing YIN and moistening the lung; Reinforcing stomach reg fluid; Clear away heart-fire relieving restlessness.Dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, and asthenia dysphoria with smothery sensation, quenches one's thirst, and calentura Tianjin is hindered, dry mouth and throat, constipation." book on Chinese herbal medicine converges and says ": Radix Ophiopogonis, the medicine of clearing away heart-fire and moistening the lung also.Main deficiency of heart-QI, palpitation with fear palpitation with a distress feeling, dimly forgetful, spirit fall; Or the lung-heat dryness of the lung, cough sound running fire, consumptive lung disease leaf scorch, dyspnea due to deficiency of losing heart, in fire volt lung, spitting of blood hemoptysis; Or asthenia exopathogenic heat, body fluid is dry few; Or taste are dry dries up, constipation due to insufficiency dyschezia; This card that all cardiopulmonary kidney spleen unit asthenic fire is strongly fragrant also.But sweet in the mouth gas is put down, energy lung benefiting gold, bitter in the mouth is cold in nature, can fall heart-fire, and body profit matter is mended, and can support medulla renis, and the merit specially controlling strain deficiency-heat is in the majority.Stagnation of QI in chest and abdomen as main in front Gu, damaging the spleen and stomach wound is full, and stomach channels is exhausted, and weakness and emaciation such as to be losed heart at the disease, then belong to strain bright." book on Chinese herbal medicine newly organized ": Radix Ophiopogonis, the volt fire in eliminating the pathogens from the lung, the pathogenic heat in clearing stomach, the impairment caused by overstrain of reinforcing the heart gas, the vomiting of hemostasis man, beneficial smart reinforcing YIN-essence, separates tired quenching the thirst, U.S. color, happy skin, and reducing the asthenic fever, separates the dryness of the lung, fixed cough, and what very can hold is monarch and making also for minister of can borrowing.But the magical effect of common people unknown Radix Ophiopogonis, often few use and can not be successfully unfortunate also.Do not know that Radix Ophiopogonis must be multiplex, strength begins large, and Gai Huofu is in lung, and sparkle liquid in doing, more than Radix Ophiopogonis, then fire can not be made; Heat is vehement in stomach, and endure its moon to the greatest extent, more than Radix Ophiopogonis, then fire can not cease.More have the fire of bladder, superinverse is in ambition, and urine drop can not go out, and people thinks that urine fire closes, due to bladder heat also, do not imitate with the medicine of water flowing, do not imitate with the agent of pathogenic fire reducing, this again what with? the gas of lid bladder, must the respectful clearly order row of the part of the body cavity above the diaphragm housing the heart and lungs, and fire is decline, and water is lower logical.The respectful clearly order of husband's part of the body cavity above the diaphragm housing the heart and lungs is reported in lung also, and heat of the lung, then making that lung is respectful is clearly not all right, and bladder fire closes, and water also closes.Therefore for logical bladder person, must the gas of lung heat clearing gold, the medicine of lung heat clearing is a lot of, all damages unhelpful, if eventually not Radix Ophiopogonis clear in have benefit, the fire of bladder can be rushed down, and don't damage the gas of bladder, but few with it, also can not be successful, lid abnormal smells from the patient Radix Ophiopogonis is flat cold, must be multiplex and the beginning has Ji also.
Radix Scutellariae: have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are by the strong feature of broad-spectrum antibacterial action, are used in fungal culture miscellaneous bacteria and infect special severe, fine by Radix Scutellariae extracting solution effect." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so evil removing: bitter in the mouth is so dampness; YIN-cold is so victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, and the disease of all damp and hot victory also, analyses it, then all diseases are from recover.Bitter cold can except damp and hot, thus small intestinal profit and water from by, source is clearly then flowed also clean.The blood person of closing, excess-heat is at blood system, and instant heating human blood room, it is obstructed to make us amenorrhea, and damp and hot solution, then Ying Qi clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood then stays knot, and is that carbuncle stain is also rotten: acute scleritis person, also, removing heat from blood heat extraction, then spontaneous recovery also for fire of moxibustion blood trouble.
BAIMI: acrid in the mouth; Sweet; Bitter; Be slightly cold; Nontoxic.Function cures mainly: main QI invigorating should spleen.
Flos Bombacis Malabarici: sweet; Light; Cool in nature.Return spleen; Liver; Large intestine channel.Function cures mainly: heat clearing away; Dampness removing; Removing toxic substances; Hemostasis.Master has loose bowels; Dysentery; Hemoptysis; Spit blood; Metrorrhagia; Incised wound is hemorrhage; Sore; Eczema.1. " the SHENGCAO property of medicine is standby to be wanted ": control dysentery disease, white person is still better.2. " book on Chinese herbal medicine asks former ": red person goes bloody dysentery, and white person controls Hakuri, decoct normal drink with military Yi nationality tea.3. " south of the Five Ridges gather medicinal herbs record ": relieve summer heat.4. " Chinese medicine is newly organized ": diuresis and stomach invigorating.5. " Nanning City's medicine will ": remuval of damp and hot.Control metrorrhagia, gold wound.6. " Guangxi Chinese medicinal herbal ": dry poison, controls malignant boil.7. Guangzhou army " conventional Chinese herbal medicine handbook ": clearing away heat-damp and promoting diuresis, controls enteritis, bacillary dysentery.
Herba Ephedrae: pungent, micro-hardship, temperature.Return lung, urinary bladder channel.Function cures mainly: diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.For anemofrigid cold, uncomfortable in chestly to breath with cough, edema due to wind pathogen edema; Bronchial asthma.Herba ephedrae nourishing the lung to arrest cough.Be used for table disease to separate, asthma and cough.
Fructus Artocarpi Heterophylli: sweet micro-acid is flat, nontoxic." function cures mainly: 1. " detailed outline ": " is quenched the thirst to separate and is tired of, relieving alcoholic intoxication, QI invigorating." 2. " register planted by Guangxi medicine ": " promotes the production of body fluid, and quenches the thirst, aid digestion."
Testa dolichoris: sweetness and bitterness; Temperature.Return spleen; Large intestine channel.Function cures mainly: removing dampness of relieving summer heat, invigorating the spleen and regulating the stomach.Accumulate in main heat-damp in summer, vomiting is had loose bowels, uncomfortable in chest indigestion and loss of appetite, beriberi edema, women's leukorrhagia.1. " book on Chinese herbal medicine is just read ": reach the capable water of flesh.2. " Anhui medical material ": spleen reinforcing removing dampness, antidiarrheal dysentery.Control alimentary toxicosis vomiting and dirarrhea, separate alcoholism.3. " medicine will is planted in Jiangsu ": control beriberi foot swollen.
Fructus Arctii: pungent, bitter, cold.Attach to the lung and stomach meridians.Function cures mainly: dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.For anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, mumps erysipelas, carbuncle sore tumefacting virus.
Cortex Fraxini: bitter, puckery, cold.Return liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, astringent therapy, improving eyesight.For hematodiarrhoea, have loose bowels, leucorrhea with red and white discharge, conjunctival congestion and swelling pain, the raw nebula film of order.1. antiinflammatory, analgesic activity.Rats by intraperitoneal injection aesculin 10 mgs/kg, diagonal angle justice dish colloidality, dextran, 5-hydroxy tryptamine and histamine " arthritis " have inhibitory action, and the intensity of suppression is respectively 35, and 28,20,8%.Also have report, aesculin PARA FORMALDEHYDE PRILLS(91,95) " arthritis " also has inhibitory action, but is weaker than diagonal angle justice dish colloidality person, and not obvious to the suppression of dextran " arthritis ".Also there is inhibitory action at aesculetin diagonal angle justice dish colloidality " arthritis " when heavy dose.Aesculin can suppress the Granuloma formation (cotton pellet method) of rat, to the erythematous response that Cavia porcellus ultraviolet radiation back causes, also inhibitory action is had, comparatively aesculin is more remarkable in the effect of aesculetin, both there is the effect of the capillary permeability significantly suppressing histamine to cause, aesculin also has faint analgesic activity (hot plate method in mice), as using the effect of morphine subcutaneous injection 5 mgs/kg as 100%, then tiring of oral 10 mgs/kg of aesculin is 14.8%.2. on the impact of urine volume and urate excretion.Early annual report fraxin has diuresis, can promote the excretion of rabbit and rheumatisant's uric acid.Aesculin is in the test of rat and rabbit, and various route of administration all can promote the excretion of uric acid.After rabbit vein injection aesculin, in initial half an hour, urine volume increases, and after this in blood, namely uric acid concentration is shown in rising, and after half an hour, namely urine volume reduces gradually, and the excretion of urine uric acid constantly increases.The increase of urine volume, after only showing medicine in the short term (may be reabsorption reduce caused), administration be after 3 ~ 4 hours, and urine volume is only 1/2 before administration.The action principle of urate excretion enhancement, according to analysis, has been sympathetic nervous system excited; And aesculin also has direct effect to kidney, namely inhibit to uric acid heavily caused by absorption.The result increased as uricopoiesis in liver increases of uric acid concentration in blood.Also have report, aesculin there is no diuresis to normal rat, and has more significant diuresis to mice.3. other effect aesculins are general neither remarkable to the effect of other organs.To the blood pressure of rabbit, breathing, intestinal tube all without effect.To guinea pig in vitro small intestinal, uterus, bladder, gallbladder and isolated frog heart and to rabbit uterus in place, rabbit ear blood vessel, Bufo siccus lower limb vascular also without effect; Also the blood flow of rabbit carotid artery, femoral artery is not affected.Aesculetin has slight boosting to rabbit, can also suppress Isolated Toad Heart and isolated rabbit intestinal, and light contraction Bufo siccus lower limb vascular, the irritability of isolated toad gastrocnemius also slightly reduces.Cortex Fraxini decoct also has some effect that is antibacterial, that treat chronic tracheitis.The chemical constitution of aesculin is similar to dicoumarol, therefore has some anticoagulant effect, and its 4% solution can absorb ultraviolet, therefore can protect skin, from the damage of sun exposure.4. drain, absorb and general toxicity horse chestnut bark glycoside oral after upper part of small intestine absorb, stomach and large intestine do not absorb; Can come across after injection in gallbladder and urine, namely occur very early in adrenal gland, testis and kidney, also can in brain.The no matter oral or intravenous injection of rat, all have discharge in urine and in stool, based on original shape, Cavia porcellus is then mainly destroyed in vivo.Aesculin 3 gs/kg or aesculetin 1 g/kg of lumbar injection are in mice, neither lethal, therefore toxicity is very low; But also there is report aesculetin subcutaneous injection 250 mgs/kg namely pernicious.Japan's Cortex Fraxini extract, to rabbit gavage every day 3 gs/kg, only causes slight lesion tissue in continuous 45 weeks, as gastrointestinal mucosa present hypersecretion, enteric plexus expand and glomerule, renal tubules degeneration; Long term injections administration, liver function and tip hemogram are all without significant change.
Cortex Acanthopanacis Radicis: sweet, sour, temperature.Function cures mainly: strengthening the spleen and stomach, aid digestion, calms the nerves, and induces sweat, stimulating milk secretion.For weakness of the spleen and stomach, dyspepsia, neurasthenia, flu, agalactia.
Herba Medicaginis: bitter, micro-puckery, flat.Function cures mainly: stomach invigorating, clearing away heat and promoting diuresis.Cure mainly enteritis, lithangiuria, nyctalopia.
Semen setariae: Gan Xian is cool.Specially enter kidney, double enter spleen, stomach.Function cures mainly: with in, kidney tonifying, heat extraction, removing toxic substances.Control taste deficiency-heat, regurgitation is vomitted, and quenches one's thirst, has loose bowels.Old Semen setariae: dysentery relieving, separates unhappy.
Semen Arecae: bitter in the mouth; Pungent; Warm in nature.Return stomach; Large intestine channel.Effect, anthelmintic; Removing food stagnancy; The therapeutic method to keep the adverse QI flowing downwards; Row water; Preventing the attack (or recurrence) of malaria.Malnutrition due to parasitic infestation; Dyspepsia; Abdominal distention; Heavy after dysentery; Foot gas; Edema; Malaria.Resisting pathogenic microbes effect Semen Arecae infusion (1:1) in vitro to trichophyton, permitted the dermatophytes such as blue achorion and had inhibitory action in various degree.Decoct and some strain of water logging agent infected by influenza A type have certain inhibitory action, and antiviral effect may be relevant with wherein contained tannin.
Semen Coicis: sweet, light, cool.Return spleen, stomach, lung meridian.Function cures mainly: spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, and row is dense in heat clearing away.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.
Poria cum Radix Pini: sweet light, flat.Enter the heart, spleen channel.Function cures mainly: mind calming, calms the nerves, diuretic.Control palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria.
Semen Phaseoli: sweet, sour is flat.GUIXIN, small intestine meridian.Function cures mainly: inducing diuresis to remove edema, removing toxic substances and promoting pus discharge.For edema distension, beriberi limb swells, jaundice dark coloured urine, beriberoid pyretic arthralgia, carbuncle sore tumefacting virus, abdominalgia with intestinal abscess.
Cortex Hibisci: sweet, tepor.Function cures mainly: clearing away heat-damp and promoting diuresis, killing parasites for relieving itching.For dysentery, leucorrhea; Eczema scrotum tinea corporis is controlled in external, tinea pedis.
Fructus Piperis: pungent, heat.Return stomach, large intestine channel.Function cures mainly: warming spleen and stomach for dispelling cold, the therapeutic method to keep the adverse QI flowing downwards, expectorant.For gastrofrigid vomiting, stomachache is had loose bowels, inappetence, epilepsy abundant expectoration.
Tremella: sweet is flat.Function cures mainly: invigorating the lung and benefiting vital QI, nourishing YIN to relieve dryness.For body is empty after being ill, chronic cough of deficiency lung, sputum mixed with blood, metrorrhagia, constipation, hypertension, sclerosis of blood vessels.
Fructus Quisqualis: sweet, temperature.Return spleen, stomach warp.Function cures mainly: killing insect and eliminating accumulation.For ascarid, enterobiasis, abdominal pain due to worm stagnation, infantile malnutrition.
Moschus: pungent, temperature.GUIXIN, spleen channel.Function cures mainly: refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.For calentura coma, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, amenorrhea ， WEIJIA, difficult labour stillborn fetus, trusted subordinate's sudden pain, carbuncle scrofula, and laryngopharynx swelling and pain, falls and flutter the pain of injury, and arthralgia pain is numb.
Foliumet Ramulus Evodiae: bitter, cold.Function cures mainly: heat-clearing and toxic substances removing, eliminating stasis to stop pain.Prevent and treat influenza, epidemic cerebrospinal meningitis, encephalitis B, heatstroke, cure cold high heat, tonsillitis, pharyngolaryngitis, lung abscess, pneumonia, malaria, rheumatic arthritis, sciatica, lumbago and skelalgia, stomachache, icterohepatitis, Gelsemium elegans Benth. (Herba Gelsemii Elegantis) is poisoning.Osteopatia sprain is controlled in external, worm venom, carbuncle furuncle and phyma poison, trauma infection contamination, eczema, dermatitis.
Preferably, the present invention can also comprise: Pericarpium Citri Reticulatae, Ganoderma, Bulbus Allii, Fructus Jujubae and Fructus Crataegi.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship; Return spleen, lung meridian, for diseases such as distension and fullness of the chest and abdomen.The pungent loose logical temperature of Pericarpium Citri tangerinae, fragrant odour, is longer than and regulates the flow of vital energy, spleen lung can be entered, therefore can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, gather around stagnant, chest and diaphragm feeling of fullness and the disease such as stagnation of QI in spleen and stomach, distension and fullness in the abdomen for lung qi, for retention of dampness in middle-JIAO, gastral cavity abdomen painful abdominal mass is swollen, have loose bowels in loose stool, and the disease such as abundant expectoration cough.Pericarpium Citri tangerinae dispelling the damp pathogen with bitter and warm drugs and can spleen invigorating circulation of qi promoting, therefore be usually used in the diseases such as retention of dampness in middle-JIAO, gastral cavity abdominal distention are vexed, loose stool greasy fur, can compatibility Rhizoma Atractylodis, Cortex Magnoliae Officinalis is with using.Be good at drying dampness to eliminate phlegm again, be control the conventional key medicine that damp-phlegm stops up lung, abundant expectoration cough, reduce for insufficiency of the spleen diet, dyspepsia, and the disease such as nausea and vomiting.This product dampness and can spleen benefiting and stimulating the appetite, is applicable to the diseases such as weakness of the spleen and stomach, diet minimizings, dyspepsia, loose stool and diarrhea, often and the fit applications such as Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria.Because it can spleen invigorating, can regulate the flow of vital energy again, therefore the assistant being often used as Qi-tonifying drug makes, and can make tonify without causing stagnation, prevent heap soil or fertilizer over and around the roots from holding back and do swollen effect, in addition, Pericarpium Citri tangerinae again can with in, stomach-QI being unable to descend normally, nausea and vomiting can be controlled.
Ganoderma: property is sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, has phlegm-dispelling functions to respiratory system, in addition, also has hepatoprotective, improves immunologic function, antibacterially waits effect.
Bulbus Allii: warm in nature, acrid in the mouth is put down; Enter spleen, stomach, lung meridian.Removing toxic substances parasite killing, reducing swelling and alleviating pain, antidiarrheal dysentery relieving, controls lung, anthelmintic, also has warming the spleen warming the stomach in addition.Control swollen ulcer drug, white bald tinea skin ulcer, dysentery is had loose bowels, pulmonary tuberculosis pertussis, ascarid pinworm, eating accumulation, coldness and pain in the epigastrium, edema distension, circulation of qi promoting removing food stagnancy, and parasite killing detoxifies.For flu, bacillary dysentery, amebic dysentery, enteritis, eating accumulation, carbuncle skin infection.Strong disinfecting: in Bulbus Allii, sulfur-containing compound has strong antibacterial and anti-inflammation functions, all has suppression and killing action to multiple coccus, bacillus, fungus and virus etc., is the one that in the natural plants found at present, antibacterial action is the strongest.Anti-curing oncoma and cancer: the elements such as the germanium in Bulbus Allii and selenium can the growth of inhibition tumor cell and cancerous cell, and experiment finds, the crowd that cancer incidence is minimum is exactly the crowd that in blood, selenium content is the highest.National Cancer tissue is thought, in the plant of the anticancer potentiality of whole world most, what rank first is Bulbus Allii.Toxin-expelling intestine-cleaning, prevention of gastrointestinal: Bulbus Allii can effectively suppress and kill the bacterial viruses such as the helicobacter pylori causing gastroenteropathy, removes the intestines and stomach noxious substance, stimulating gastrointestinal mucosa, promotes appetite, accelerates digestion.Reduce blood glucose, prevent diabetes: Bulbus Allii can promote the secretion of insulin, increase histiocyte to the absorption of glucose, improve human glucose tolerance, blood sugar level in rapid reduction body, and the various pathogenic bacterias because of infection-induced diabetes can be killed, thus effective prevention and therapy diabetes.Control cardiovascular and cerebrovascular disease: Bulbus Allii can prevent the lipidosis in cardiovascular and cerebrovascular vessel, the metabolism of induced tissue fat inside, remarkable increase fibrinolytic activity, reduces cholesterol, suppresses hematoblastic gathering, reduce plasma concentration, increase arteriolar expansion ratio, impel vasodilation, regulate blood pressure, increase the permeability of blood vessel, thus suppress formation and the prevention of arterial sclerosis of thrombosis.Eat 2 ~ 3 lobe Bulbus Alliis every day, be the preferably the most easy way of blood pressure lowering, Bulbus Allii can help the right quantity of a kind of enzyme in holder and avoid occurring hypertension.
Fructus Jujubae: there is immunosuppressive action, the ethanol extract of Fructus Jujubae with every day 100mg to rat oral gavage, display Fructus Jujubae has same immunosuppressant with azathioprine; The generation of antibody can be suppressed to atopic diseases.Fructus Jujubae ethanol extract may have inhibitory action to rat reactive antibody, and other effects of inhibitory action are not produced to non-reacted antibody: the two glucoside A of the flavone in Fructus Jujubae, pharmacological evaluation proves have calmness, hypnosis and hypotensive effect, and Fructus Jujubae has the effect increasing cAMP in leukocyte.Fructus Jujubae decoct can reduce the damage of CCl4 to Rabbit Liver.The swimming time of mice can be extended.Nearest report Fructus Jujubae has the proliferation function of anticancer.
Fructus Crataegi: section is dried, put in pot large stir-fry of useing force and be degree to outer wrinkly face brown, inner yellowish-brown, spray clear water, taking-up is dried, and is Fructus Crataegi (parched to brown).There is appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, circulation of qi promoting of reducing phlegm effect, meridian distribution of property and flavor, sour, sweet, slightly warm in nature.Main component is containing chlorogenic acid, caffeic acid, Crataegolic acid, neat chrysanthemum fruit acid, Quercetin, ursolic acid, oleanolic acid, hyperin, epicatechin etc.Oral Fructus Crataegi can increase digestive enzyme, promotes decomposition and the digestion of fat, to because of eat meat or greasy too much caused by distension and fullness in the abdomen, belch, anorexia, stomachache, diarrhoea person, curative effect is especially good.In addition, modern medicines test shows, Fructus Crataegi has slow and lasting effect reduced blood pressure, and also can reduce cholesterol and triglyceride, atherosclerosis, but also can diastole coronary artery, increases myocardial contraction, to arrhythmia.Therefore, be conducive to preventing and treating hypertension, hyperlipidemia, arteriosclerosis and coronary heart disease.
Embodiment 1 medicine 1
The embodiment of the present invention 1 provides a kind of medicine being used for the treatment of swine paratyphoid, be made up of following crude drug: Radix Ophiopogonis 21 weight portion, Radix Scutellariae 15 weight portion, BAIMI 21 weight portion, Flos Bombacis Malabarici 15 weight portion, Herba Ephedrae 13 weight portion, Fructus Artocarpi Heterophylli 15 weight portion, Testa dolichoris 15 weight portion, Fructus Arctii 15 weight portion, Cortex Fraxini 23 weight portion, Cortex Acanthopanacis Radicis 22 weight portion, Herba Medicaginis 20 weight portion, Semen setariae 20 weight portion, Semen Arecae 15 weight portion, Semen Coicis 20 weight portion, Poria cum Radix Pini 15 weight portion, Semen Phaseoli 15 weight portion, Cortex Hibisci 15 weight portion, Fructus Piperis 13 weight portion, Tremella 15 weight portion, Fructus Quisqualis 13 weight portion, Moschus 17 weight portion and Foliumet Ramulus Evodiae 21 weight portion.
The preparation method of medicine comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials, after mixing, be ground into powder; Added by powder in cold water and soak 24 hours, with slow fire boiling, decocting time is 2 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 3 times of the powder quality that the first step obtains;
Second step, the first step is filtered the filtering residue obtained again add in cold water, with slow fire boiling 2 times, each to decoct 1 hour, filter and merge filtrate, obtaining the second filtrate, the quality of the water added and identical in the first step;
3rd step, the first filtrate and the second filtrate merged, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, and ensure that inlet temperature is at 170 DEG C, leaving air temp 60 DEG C, is ground into 200 orders subsequently, obtains drug powder.
Embodiment 2 medicine 2
The embodiment of the present invention 2 provides a kind of medicine being used for the treatment of swine paratyphoid, be made up of following crude drug: Radix Ophiopogonis 20 weight portion, Radix Scutellariae 19 weight portion, BAIMI 25 weight portion, Flos Bombacis Malabarici 13 weight portion, Herba Ephedrae 12 weight portion, Fructus Artocarpi Heterophylli 15 weight portion, Testa dolichoris 16 weight portion, Fructus Arctii 15 weight portion, Cortex Fraxini 25 weight portion, Cortex Acanthopanacis Radicis 24 weight portion, Herba Medicaginis 17 weight portion, Semen setariae 20 weight portion, Semen Arecae 15 weight portion, Semen Coicis 20 weight portion, Poria cum Radix Pini 15 weight portion, Semen Phaseoli 16 weight portion, Cortex Hibisci 15 weight portion, Fructus Piperis 14 weight portion, Tremella 12 weight portion, Fructus Quisqualis 15 weight portion, Moschus 12 weight portion, Foliumet Ramulus Evodiae 17 weight portion, Pericarpium Citri Reticulatae 23 weight portion, Ganoderma 24 weight portion, Bulbus Allii 12 weight portion, Fructus Jujubae 25 weight portion and Fructus Crataegi 18 weight portion.
The preparation method of medicine comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials, after mixing, be ground into powder; Added by powder in cold water and soak 36 hours, with slow fire boiling, decocting time is 3 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 5 times of the powder quality that the first step obtains;
Second step, the first step is filtered the filtering residue obtained again add in cold water, with slow fire boiling 3 times, each to decoct 1.5 hours, filter and merge filtrate, obtaining the second filtrate, the quality of the water added and identical in the first step;
3rd step, the first filtrate and the second filtrate merged, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, and ensure that inlet temperature is at 160 DEG C DEG C, leaving air temp 70 DEG C, is ground into 300 orders subsequently, obtains drug powder.
Toxicity test
1, cumulative toxicity test report
Select 20 healthy mices, female, each 10 of hero, with the medicine of the embodiment of the present invention 1 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD50,0.50LD50, the LD50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.With the medicine 2 of embodiment 2 for object, carry out toxicity test according to the method described above, result is as identical in embodiment 1.
2, acute toxicity test
Application NIH mice 40, SPF level, male and female half and half, body weight 16 ~ 20g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The medicine dissolution prepared by embodiments of the invention 1 is in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.9 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.The medicine LD50>32.9 crude drug/kg of the Mouse oral gavage embodiment of the present invention 1, every day, maximum dosage-feeding was 65.8g crude drug/kg/ day.The clinical application amount of the embodiment of the present invention 1 medicine 1 be 3g crude drug/day/head, pig weight is in 6kg, and average dosage is 0.5g crude drug/kg/ day.By weighing machine: the dosis tolerata of the medicine of mice (average weight is in 20g) the oral administration gavage embodiment of the present invention 1 is 131 times of quantity.Therefore the acute toxicity of the medicine 1 of the embodiment of the present invention 1 is low, clinical drug safety.With the medicine 2 of embodiment 2 for object, carry out toxicity test according to the method described above, result is as identical in embodiment 1.
Clinical trial
(1) laboratory animal
In August, 2012, pig farm, Accessories during Binzhou, Shandong Province finds that the phenomenon of pig death appears in piglet group, clinical examination is carried out to swinery, find that in swinery, piglet occurs that fever is to more than 41 DEG C mostly, there is the phenomenon of diarrhoea, excretion canescence or yellow stench feces, dyspnea, under the basal part of the ear and abdomen, skin has purpura; Dead piglet is dissected, finds that congestion appears in the skin such as ear, abdominal part, with the rotten milk of one deck lark on intestinal mucosa, liver, renomegaly, hemorrhage.Through clinical examination, have 290 piglets nearly to suffer from gastric ulcer, select wherein 150 body weight in the ill piglet experiment pig the most of about 8kg.
(2) test method
By 150 ill piglets with entering to be divided into three experimental grouies, often organize 50, often organizing average weight is 8kg.Three components does not use the medicine 1(embodiment group 1 of the embodiment of the present invention 1), the medicine 2(embodiment group 2 of embodiment 2) and conventional medicament (matched group) treat.Medicine 1 and medicine 2 are added feedstuff according to the percentage by weight of feedstuff 5-12% by embodiment 1 and 2 respectively; Conventional medicament selects oxytetracycline, every day every kg body weight 50-100 milligram, point 2-3 time is oral.Test period is 3-7 days.
(3) criterion of therapeutical effect
Recovery from illness: symptom, sign, microbiology and laboratory examination four all recover normal;
Effective: symptom, sign, microbiology and laboratory examination wherein one do not recover normal;
Effective: after medication, the state of an illness takes a turn for the better to some extent, but obvious not; Symptom, sign, microbiology and laboratory examination wherein at least two do not recover normal;
Invalid: after medication, the state of an illness even increases the weight of without improvement.
Wherein, recovery from illness and effective number count effective percentage.
(4) therapeutic outcome
The results are shown in Table 1, from therapeutic effect, adopt medicine of the present invention to be more than 88% to the treated effect of swine paratyphoid, higher than matched group.
Data as can be seen from table 1: compared with matched group, use the Drug therapy pig swine paratyphoid of the embodiment of the present invention 1 and embodiment 2, have evident in efficacy, that cure rate is high advantage; Find in long-term observation subsequently, embodiment group 1 and embodiment group 2 piglet of curing again sickness rate is starkly lower than the pig of matched group.
Concrete case
Case 1
In May, 2011, Wu finds that 17 ablactational baby pig appearance fever all is in various degree to more than 41 DEG C, diarrhoea, excretion canescence or yellow stench feces, dyspnea, and under the basal part of the ear and abdomen, skin has the symptoms such as purpura, is swine paratyphoid through tentative diagnosis.In feedstuff, add the medicine of the embodiment of the present invention 1 of feedstuff gross weight 8%, adhere to use 5 days, 17 piglets all recover normal.
Case 2
In August, 2012, Distributions in Liaocheng of Shandong Province pig farm, finds that 1 piglet is dead, and the piglet appearance all in various degree of 35 is had a fever to more than 41 DEG C, diarrhoea, excretion canescence or yellow stench feces, dyspnea, under the basal part of the ear and abdomen, skin has the symptoms such as purpura, dead piglet is dissected, find that congestion appears in the skin such as abdominal part, with the rotten milk of one deck lark on intestinal mucosa, liver, renomegaly, hemorrhage.Be diagnosed as swine paratyphoid.35 ill piglet isolation fed separately, in feedstuff, add the medicine of the embodiment of the present invention 2 of feedstuff gross weight 12%, adhere to use 3 days, 30 piglets all recover normal, and continue use three days, other piglets all recover normal.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (6)
1. be used for the treatment of the medicine of swine paratyphoid, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Radix Ophiopogonis 10-30 weight portion, Radix Scutellariae 10-20 weight portion, BAIMI 15-30 weight portion, Flos Bombacis Malabarici 10-20 weight portion, Herba Ephedrae 10-15 weight portion, Fructus Artocarpi Heterophylli 10-20 weight portion, Testa dolichoris 10-20 weight portion, Fructus Arctii 10-20 weight portion, Cortex Fraxini 15-30 weight portion, Cortex Acanthopanacis Radicis 15-30 weight portion, Herba Medicaginis 15-25 weight portion, Semen setariae 10-30 weight portion, Semen Arecae 10-20 weight portion, Semen Coicis 10-30 weight portion, Poria cum Radix Pini 10-20 weight portion, Semen Phaseoli 10-20 weight portion, Cortex Hibisci 10-20 weight portion, Fructus Piperis 10-20 weight portion, Tremella 10-20 weight portion, Fructus Quisqualis 10-20 weight portion, Moschus 10-25 weight portion and Foliumet Ramulus Evodiae 15-25 weight portion.
2. the medicine being used for the treatment of swine paratyphoid according to claim 1, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Radix Ophiopogonis 21 weight portion, Radix Scutellariae 15 weight portion, BAIMI 21 weight portion, Flos Bombacis Malabarici 15 weight portion, Herba Ephedrae 13 weight portion, Fructus Artocarpi Heterophylli 15 weight portion, Testa dolichoris 15 weight portion, Fructus Arctii 15 weight portion, Cortex Fraxini 23 weight portion, Cortex Acanthopanacis Radicis 22 weight portion, Herba Medicaginis 20 weight portion, Semen setariae 20 weight portion, Semen Arecae 15 weight portion, Semen Coicis 20 weight portion, Poria cum Radix Pini 15 weight portion, Semen Phaseoli 15 weight portion, Cortex Hibisci 15 weight portion, Fructus Piperis 13 weight portion, Tremella 15 weight portion, Fructus Quisqualis 13 weight portion, Moschus 17 weight portion and Foliumet Ramulus Evodiae 21 weight portion.
3. be used for the treatment of the medicine of swine paratyphoid, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Radix Ophiopogonis 10-30 weight portion, Radix Scutellariae 10-20 weight portion, BAIMI 15-30 weight portion, Flos Bombacis Malabarici 10-20 weight portion, Herba Ephedrae 10-15 weight portion, Fructus Artocarpi Heterophylli 10-20 weight portion, Testa dolichoris 10-20 weight portion, Fructus Arctii 10-20 weight portion, Cortex Fraxini 15-30 weight portion, Cortex Acanthopanacis Radicis 15-30 weight portion, Herba Medicaginis 15-25 weight portion, Semen setariae 10-30 weight portion, Semen Arecae 10-20 weight portion, Semen Coicis 10-30 weight portion, Poria cum Radix Pini 10-20 weight portion, Semen Phaseoli 10-20 weight portion, Cortex Hibisci 10-20 weight portion, Fructus Piperis 10-20 weight portion, Tremella 10-20 weight portion, Fructus Quisqualis 10-20 weight portion, Moschus 10-25 weight portion, Foliumet Ramulus Evodiae 15-25 weight portion, Pericarpium Citri Reticulatae 15-30 weight portion, Ganoderma 15-25 weight portion, Bulbus Allii 10-15 weight portion, Fructus Jujubae 15-35 weight portion and Fructus Crataegi 15-25 weight portion.
4. the medicine being used for the treatment of swine paratyphoid according to claim 3, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Radix Ophiopogonis 15-25 weight portion, Radix Scutellariae 15-20 weight portion, BAIMI 20-30 weight portion, Flos Bombacis Malabarici 10-15 weight portion, Herba Ephedrae 10-15 weight portion, Fructus Artocarpi Heterophylli 12-18 weight portion, Testa dolichoris 12-19 weight portion, Fructus Arctii 10-20 weight portion, Cortex Fraxini 19-30 weight portion, Cortex Acanthopanacis Radicis 19-30 weight portion, Herba Medicaginis 15-20 weight portion, Semen setariae 15-25 weight portion, Semen Arecae 10-20 weight portion, Semen Coicis 15-25 weight portion, Poria cum Radix Pini 10-20 weight portion, Semen Phaseoli 13-18 weight portion, Cortex Hibisci 12-19 weight portion, Fructus Piperis 13-15 weight portion, Tremella 10-14 weight portion, Fructus Quisqualis 13-20 weight portion, Moschus 10-20 weight portion, Foliumet Ramulus Evodiae 15-20 weight portion, Pericarpium Citri Reticulatae 20-25 weight portion, Ganoderma 20-25 weight portion, Bulbus Allii 10-13 weight portion, Fructus Jujubae 20-30 weight portion and Fructus Crataegi 15-20 weight portion.
5. the medicine being used for the treatment of swine paratyphoid according to claim 3, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Radix Ophiopogonis 20 weight portion, Radix Scutellariae 19 weight portion, BAIMI 25 weight portion, Flos Bombacis Malabarici 13 weight portion, Herba Ephedrae 12 weight portion, Fructus Artocarpi Heterophylli 15 weight portion, Testa dolichoris 16 weight portion, Fructus Arctii 15 weight portion, Cortex Fraxini 25 weight portion, Cortex Acanthopanacis Radicis 24 weight portion, Herba Medicaginis 17 weight portion, Semen setariae 20 weight portion, Semen Arecae 15 weight portion, Semen Coicis 20 weight portion, Poria cum Radix Pini 15 weight portion, Semen Phaseoli 16 weight portion, Cortex Hibisci 15 weight portion, Fructus Piperis 14 weight portion, Tremella 12 weight portion, Fructus Quisqualis 15 weight portion, Moschus 12 weight portion, Foliumet Ramulus Evodiae 17 weight portion, Pericarpium Citri Reticulatae 23 weight portion, Ganoderma 24 weight portion, Bulbus Allii 12 weight portion, Fructus Jujubae 25 weight portion and Fructus Crataegi 18 weight portion.
6. the preparation method being used for the treatment of the medicine of swine paratyphoid as described in any one of claim 1-5, is characterized in that, described preparation method comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials, after mixing, be ground into powder; Added by powder in cold water and soak 24 hours ~ 36 hours, with slow fire boiling, decocting time is 2 hours ~ 3 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 3 ~ 5 times of the powder quality that the first step obtains;
Second step, the first step is filtered the filtering residue obtained again add in cold water, with slow fire boiling 2 ~ 4 times, each to decoct 1 hour ~ 2 hours, filter and merge filtrate, obtaining the second filtrate, the quality of the water added and identical in the first step;
3rd step, the first filtrate and the second filtrate merged, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, ensure that inlet temperature is at 160 DEG C ~ 170 DEG C, leaving air temp 50 DEG C ~ 70 DEG C, be ground into 200 order ~ 400 orders subsequently, obtain drug powder.
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| CN102038099A (en) * | 2010-09-14 | 2011-05-04 | 周剑峰 | Feed additive for preventing and treating pig paratyphus |
| CN102613412A (en) * | 2012-04-10 | 2012-08-01 | 胡海波 | Feed and traditional Chinese medicine for treating pigling epidemic diarrhea and preparation method thereof |
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| CN102038099A (en) * | 2010-09-14 | 2011-05-04 | 周剑峰 | Feed additive for preventing and treating pig paratyphus |
| CN102613412A (en) * | 2012-04-10 | 2012-08-01 | 胡海波 | Feed and traditional Chinese medicine for treating pigling epidemic diarrhea and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 中药治疗仔猪副伤寒;于华光;《中兽医学杂志》;19951231(第1期);13-14 * |
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