CN104208291A - Chinese medicine preparation for treating heat strangury and preparation method thereof - Google Patents

Abstract

The invention discloses a Chinese medicine preparation for treating heat strangury. The Chinese medicine preparation is characterized by comprising the following bulk drugs in parts by weight: 10-20 parts of seeds of cowherb, 10-20 parts of fructus kochiae, 10-20 parts of rosa laevigata, 10-20 parts of gallnut, 10-20 parts of white gourd kernel, 10-20 parts of fried semen pharbitidis, 10-20 parts of euphorbia kansui, 10-20 parts of dried rhizome of rehmannia, 10-20 parts of giant knot weed, 10-20 parts of prepared fleece flower root, 10-20 parts of tuckahoe, 10-20 parts of red peony root, 10-20 parts of root of red-rooted salvia, 10-20 parts of chingma abutilon seed, 10-20 parts of grifola, 10-20 parts of verbena, 10-20 parts of root of large-flowered skullcap, 10-20 parts of glossy privet fruit, 10-20 parts of eclipta, 10-20 parts of patrinia and 10-20 parts of dandelion. The Chinese medicine preparation has effects of clearing away heat and toxic materials, resisting bacteria and eliminating inflammation, inducing diuresis for treating stranguria and simulating the circulation of blood to reduce swelling; by using the Chinese medicine composition, the disappearance time of urinary tract infection symptoms and physical symptoms can be obviously shortened, and the bacterium removal rate can be improved; and meanwhile, by adopting the Chinese medicine preparation to treat the urinary tract infection, the defects of increase of drug-fast bacteria, dysbacteriosis and damage to liver and kidney functions and the like caused by using antibiotics for a long time and extensively can be avoided.

Description

A kind of Chinese medicine preparation for the treatment of pyretic stranguria and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials, particularly a kind of Chinese medicine preparation for the treatment of pyretic stranguria and preparation method thereof.

Background technology

Pyretic stranguria, belongs to the scope of Chinese medicine stranguria, comprising the illness such as acute and chronic prostatitis, prostatic hyperplasia, urgent, chronic nephropyeltis, cystitis, urethritis of modern medicine.Many because throwing off restraint hot, the delicious food of food; Or excessive drinking too, leads to damp and hot; Or experience pathogenic summer-heat in time removing summer-heat, and cause damp and hotly noting in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels; Or lower the moon is unclean, foul heresy invades the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, leads to damp and hot; Or the heresy of wind heat wind and cold attacks table in an opponent's defence, Taiyang channel gas is first sick, the heresy of priming damp-heat in the urinary bladder, and pathogen is full of in meridian of Foot-TAI YANG and internal organs; Or because of hyperactivity of heart-fire, move down small intestinal.All above because all causing the damp-heat accumulation part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, functioning of bladder is unfavorable, and pyretic stranguria occurs." all source of disease marquis opinions " meaning: pyretic stranguria person three Jiao has heat, and gas is fought in kidney, flows in born of the same parents and forms pouring also, its shape hot urination.

Motherland's medical science is thought, prostatitis, prostatic hyperplasia, prostate hyperplasia etc. also belong to pyretic stranguria category, and pathogenesis is retention of damp-heat in the urinary bladder, disturbance in functioning of QI, disturbance in water passage; The anxious therapeutic quality of lid bad temper therefore urinate frequently anxious; Damp and hot heap soil or fertilizer over and around the roots is contained, and mechanism of qi loses a surname, therefore urine is difficult puckery; Damp and hotly accumulate steaming, scorching hot twinge, therefore yellowish urine is red short.Urinary tract infection is to have a large amount of bacterial reproduction in urine, to cause urinary tract inflammation, and with frequent micturition, urgent micturition, dysurea, urinary tract infection symptom etc. for clinical characters.Pyretic stranguria one is demonstrate,proved, and common people are commonly using eight just, bavin a kind of reed mentioned in ancient books generation controls it, have sequel time right.The method of YIN nourishing if assistant people is reinforced the kidney, but often receive good effect, concrete grammar is clearing away heat-damp and promoting diuresis while, mergings tonifying the kidney to reduce urination, the product at YIN nourishing increasing night, often with synthesis sides such as Caulis Lonicerae, Radix Isatidis, Poria, Rhizoma Alismatis etc. and Pill for Decreasing Urination, ERZHI WAN, Radix Scrophulariaes.Pill for Decreasing Urination is made up of the Radix Linderae, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, is the recipe of the kidney warming contracting spring, and She Zhi pyretic stranguria is every Fang Biyong almost, can not be limited to stranguria and avoid saying of benefit.Gonorrhea controls kidney, and ancients early have bright instruction.Control in pyretic stranguria side the product applying tonifying the kidney to reduce urination, obviously can not only alleviate urinary tract excitation symptom, and the product using relieving stranguria by diuresis can be reduced.In this external treatment pouring side, also conventional application Radix Scrophulariae, Radix Adenophorae (Radix Glehniae), Herba Ecliptae, Fructus Ligustri Lucidi such as to give at the product that YIN nourishing increases night.Because caused by the solid many damp-heat accumulations of disease that pyretic stranguria oliguria is puckery, also relevant with YIN-fluid being insufficient.Treatise on Febrile Diseases institute cloud: " deficiency of YIN difficulty in urination " has just reacted this part pathology of stranguria.Control in pouring side for this reason and increase except the product at night except applying YIN nourishing, also should avoid the relieving stranguria by diuresis medicine by bitter cold impairment of YIN as far as possible.To the treatment of some so-called Chronic urinary infection acute attack patients, on the basis of reusing nourishing YIN and clearing away heat, sometimes can without the product of relieving stranguria by diuresis.

Urinary tract infection is divided into upper urinary tract infection and lower urinary tract infection, is modal diseases of urinary system, is also the modal infectious disease of adult.Mainly contain bacteriological infection to cause, any antibacterial invades and all can cause, but modal is intestinal gram negative bacilli, wherein common with escherichia coli, account for 70% of urinary tract infection, other is followed successively by Bacillus proteus, klebsiella bacillus, aerobacteria, Bacillus alcaligenes, group B streptococcus, bacillus pyocyaneus and staphylococcus.Due to prostatitis with urinary system infection is many is caused by sensitive organism or pathogenic microorganism, therefore doctor trained in Western medicine is main mainly with broad-spectrum antibiotic anti-inflammation; And the burnt damp-heat accumulation of differential diagnosis in tcm subordinate, functioning of bladder is unfavorable and the various prostatosis that causes and urinary system infection (both pyretic stranguria), be then the main rule for the treatment of with heat clearing away, diuretic, treating stranguria, immunity, compensate for western medicine and medical practitioners large to hepatorenal damage, only focus on the deficiency that reparation and immunity are not focused in treatment.

Summary of the invention

Technical problem to be solved by this invention is, due to prostatitis with urinary system infection is many is caused by sensitive organism or pathogenic microorganism, therefore doctor trained in Western medicine is main mainly with broad-spectrum antibiotic anti-inflammation; And the burnt damp-heat accumulation of differential diagnosis in tcm subordinate, functioning of bladder is unfavorable and the various prostatosis that causes and urinary system infection (both pyretic stranguria), be then the main rule for the treatment of with heat clearing away, diuretic, treating stranguria, immunity, compensate for western medicine and medical practitioners large to hepatorenal damage, only focus on the deficiency that reparation and immunity are not focused in treatment.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of pyretic stranguria, described in it, the parts by weight of Chinese medicine preparation crude drug are: Semen Vaccariae 10 ~ 20 parts, the Fructus Kochiae 10 ~ 20 parts, Fructus Rosae Laevigatae 10 ~ 20 parts, Galla Chinensis 10 ~ 20 parts, Semen Benincasae 10 ~ 20 parts, Semen Pharbitidis (parched) 10 ~ 20 parts, Radix Kansui 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Paeoniae Rubra 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Semen Abutili 10 ~ 20 parts, Polyporus 10 ~ 20 parts, Herba Verbenae 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Herba Ecliptae 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts.

The Chinese medicine preparation of described treatment pyretic stranguria, described in it, the parts by weight of Chinese medicine preparation crude drug are: Semen Vaccariae 10 ~ 15 parts, the Fructus Kochiae 10 ~ 15 parts, Fructus Rosae Laevigatae 10 ~ 15 parts, Galla Chinensis 10 ~ 15 parts, Semen Benincasae 10 ~ 15 parts, Semen Pharbitidis (parched) 10 ~ 15 parts, Radix Kansui 10 ~ 15 parts, 10 ~ 15 parts, the Radix Rehmanniae, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, Radix Polygoni Multiflori Preparata 10 ~ 15 parts, 10 ~ 15 parts, Poria, Radix Paeoniae Rubra 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Semen Abutili 10 ~ 20 parts, Polyporus 10 ~ 20 parts, Herba Verbenae 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Herba Ecliptae 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts.

The Chinese medicine preparation of described treatment pyretic stranguria, described in it, the parts by weight of Chinese medicine preparation crude drug are: Semen Vaccariae 10 ~ 20 parts, the Fructus Kochiae 10 ~ 20 parts, Fructus Rosae Laevigatae 10 ~ 20 parts, Galla Chinensis 10 ~ 20 parts, Semen Benincasae 10 ~ 20 parts, Semen Pharbitidis (parched) 10 ~ 20 parts, Radix Kansui 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Paeoniae Rubra 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Semen Abutili 10 ~ 15 parts, Polyporus 10 ~ 15 parts, Herba Verbenae 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, Herba Ecliptae 10 ~ 15 parts, Herba Patriniae 10 ~ 15 parts, Herba Taraxaci 10 ~ 15 parts.

For solving the problems of the technologies described above, the invention provides a kind of preparation method for the treatment of dysurea, the red short Chinese medicine preparation of yellowish urine, it is characterized in that, the preparation process of described Chinese medicine preparation comprises:

A, get crude drug and put into ethanol and soak, heat is extracted 2 times, and becoming paste, is component 1;

B, medicinal residues extracting in water 2 times, thickening filtration is paste, is component 2;

C, above-mentioned two kinds of pastes to be merged, be condensed into powder and incapsulate.

In described step a, crude drug can be got add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, stand for standby use, becomes component 1.

In described step b, the medicinal residues of the crude drug above-mentioned ethanol extraction can crossed add 10 times of water gagings, heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill; Above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.08; Being concentrated into relative density is 1.20, and the extractum of temperature to 60 DEG C-70 DEG C, stand for standby use, becomes component 2.

In described step c, the extractum of component 1 and component 2 can be merged, then put into concentrating under reduced pressure tank, being evaporated to relative density is 1.20, then takes out, and puts into drying machine drying powdered, puts into capsule, becomes capsule.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of dysurea, the red short Chinese medicine preparation of yellowish urine, and the dosage form of described preparation is pill, and preparation method comprises:

By the roguing of described component crude drug, dry, be ground into granule, soak 1 hour; Soaked raw material is put in multi-function extractor and decocts with water secondary; Add up the water of medical material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of total amount 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters; The filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, convection drying powdered; Then add Mel and be twisted into pill.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of dysurea, the red short Chinese medicine preparation of yellowish urine, and the dosage form of described preparation is that the preparation method of tablet comprises the following steps:

First Semen Vaccariae, Fructus Rosae Laevigatae steam method are distilled according to described number, obtain crystal, for subsequent use as component 1; Get the 60-90% soak with ethanol 1-2 hour that the medicinal residues mixing surplus stock after distillation adds 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, concentrated solution is settled into extractum shape, mass continues heating and is concentrated into extractum shape, stand for standby use, becomes component 2; The component 1 of distillation extraction and the component 2 of ethanol extraction are mixed, tablet made by tabletting.

The red short Chinese medicine preparation of described treatment dysurea, yellowish urine, the dosage form of preparation described in it can be: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation, solution or injection.

The present invention has effect of heat-clearing and toxic substances removing, anti-inflammation, inducing diuresis for treating stranguria syndrome, promoting blood circulation and detumescence, uses the present invention obviously can shorten the extinction time of urinary tract infection symptom and sign, and can improve bacteria clearance; Be usually used in the treatments such as urgent, chronic nephropyeltis, cystitis, urethritis, lithangiuria, prostatitis, vaginitis, pelvic inflammatory disease, cervicitis, gonorrhea and sexually transmitted disease (STD) sequela.Pharmacological evaluation has excellent antibacterial action to Gram-positive, negative bacterium such as staphylococcus aureus, escherichia coli, Bacillus typhi, dysentery bacterium, bacillus pyocyaneus, Bacillus proteus, gonococcuss.Use the present invention obviously can shorten the extinction time of urinary tract infection symptom and sign, and can bacteria clearance be improved, can be used as a kind of active drug for the treatment of urinary tract infection.Meanwhile, use Relinqing Granula treatment urinary tract infection, can avoid using antibiosis rope and the shortcomings such as the fastbacteria that causes increases, dysbacteriosis and infringement hepatic and renal function because of long-term, a large amount of, in Clinical practice, not find obvious toxic and side effects.

Detailed description of the invention

Pyretic stranguria, belongs to the scope of Chinese medicine stranguria, comprising the illness such as acute and chronic prostatitis, prostatic hyperplasia, urgent, chronic nephropyeltis, cystitis, urethritis of modern medicine.Many because throwing off restraint hot, the delicious food of food; Or excessive drinking too, leads to damp and hot; Or experience pathogenic summer-heat in time removing summer-heat, and cause damp and hotly noting in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels; Or lower the moon is unclean, foul heresy invades the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, leads to damp and hot; Or the heresy of wind heat wind and cold attacks table in an opponent's defence, Taiyang channel gas is first sick, the heresy of priming damp-heat in the urinary bladder, and pathogen is full of in meridian of Foot-TAI YANG and internal organs; Or because of hyperactivity of heart-fire, move down small intestinal.All above because all causing the damp-heat accumulation part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, functioning of bladder is unfavorable, and pyretic stranguria occurs." all source of disease marquis opinions " meaning: " pyretic stranguria person three Jiao has heat, and gas is fought in kidney, flows in born of the same parents and forms pouring also, its shape hot urination.″

Motherland's medical science is thought, prostatitis, prostatic hyperplasia, prostate hyperplasia etc. also belong to pyretic stranguria category, and pathogenesis is retention of damp-heat in the urinary bladder, disturbance in functioning of QI, disturbance in water passage; The anxious therapeutic quality of lid bad temper therefore urinate frequently anxious; Damp and hot heap soil or fertilizer over and around the roots is contained, and mechanism of qi loses a surname, therefore urine is difficult puckery; Damp and hotly accumulate steaming, scorching hot twinge, therefore yellowish urine is red.Urinary tract infection is to have a large amount of bacterial reproduction in urine, to cause urinary tract inflammation, and with frequent micturition, urgent micturition, dysurea, urinary tract infection symptom etc. for clinical characters.Urinary tract infection is divided into upper urinary tract infection and lower urinary tract infection, it is modal diseases of urinary system, also be that the modal infectious disease glass of adult mainly contains bacteriological infection and causes, any antibacterial invades and all can cause, but modal is intestinal gram negative bacilli, wherein common with escherichia coli, account for more than 70% of urinary tract infection.

Pyretic stranguria, belongs to the scope of Chinese medicine stranguria, comprising the illness such as acute and chronic prostatitis, prostatic hyperplasia, urgent, chronic nephropyeltis, cystitis, urethritis of modern medicine.Many because throwing off restraint hot, the delicious food of food; Or excessive drinking too, leads to damp and hot; Or experience pathogenic summer-heat in time removing summer-heat, and cause damp and hotly noting in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels; Or lower the moon is unclean, foul heresy invades the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, leads to damp and hot; Or the heresy of wind heat wind and cold attacks table in an opponent's defence, Taiyang channel gas is first sick, the heresy of priming damp-heat in the urinary bladder, and pathogen is full of in meridian of Foot-TAI YANG and internal organs; Or because of hyperactivity of heart-fire, move down small intestinal.All above because all causing the damp-heat accumulation part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, functioning of bladder is unfavorable, and pyretic stranguria occurs." all source of disease marquis opinions " meaning: pyretic stranguria person three Jiao has heat, and gas is fought in kidney, flows in born of the same parents and forms pouring also, its shape hot urination.

Motherland's medical science is thought, prostatitis, prostatic hyperplasia, prostate hyperplasia etc. also belong to pyretic stranguria category, and pathogenesis is retention of damp-heat in the urinary bladder, disturbance in functioning of QI, disturbance in water passage; The anxious therapeutic quality of lid bad temper therefore urinate frequently anxious; Damp and hot heap soil or fertilizer over and around the roots is contained, and mechanism of qi loses a surname, therefore urine is difficult puckery; Damp and hotly accumulate steaming, scorching hot twinge, therefore yellowish urine is red short.Urinary tract infection is to have a large amount of bacterial reproduction in urine, to cause urinary tract inflammation, and with frequent micturition, urgent micturition, dysurea, urinary tract infection symptom etc. for clinical characters.

Urinary tract infection is divided into upper urinary tract infection and lower urinary tract infection, is modal diseases of urinary system, is also the modal infectious disease of adult.Mainly contain bacteriological infection to cause, any antibacterial invades and all can cause, but modal is intestinal gram negative bacilli, wherein common with escherichia coli, account for 70% of urinary tract infection, other is followed successively by Bacillus proteus, klebsiella bacillus, aerobacteria, Bacillus alcaligenes, group B streptococcus, bacillus pyocyaneus and staphylococcus.Due to prostatitis with urinary system infection is many is caused by sensitive organism or pathogenic microorganism, therefore doctor trained in Western medicine is main mainly with broad-spectrum antibiotic anti-inflammation; And the burnt damp-heat accumulation of differential diagnosis in tcm subordinate, functioning of bladder is unfavorable and the various prostatosis that causes and urinary system infection (both pyretic stranguria), be then the main rule for the treatment of with heat clearing away, diuretic, treating stranguria, immunity, compensate for western medicine and medical practitioners large to hepatorenal damage, only focus on the deficiency that reparation and immunity are not focused in treatment.

Semen Vaccariae: be the dry seed of pinkwort Vaccaria segetalis Vaccariasegetalis (neck) Garcker, there is promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, expedite the emergence of the function of stimulating milk secretion.Cure mainly menoxenia, agalactosis, difficult labour, the diseases such as carbuncle furunculosis are the important medicines of clinical conventional stimulating milk secretion.Cure mainly: blood stasis amenorrhea, dysmenorrhea, difficult labour; Lack of lactation after delivery, acute mastitis swells and ache; Pyretic stranguria, stranguria with blood, stranguria caused by urinary stone.. " property of medicine opinion ": control pathogenic wind toxic, promoting blood circulation." detailed outline ": diuresis.

The Fructus Kochiae is cold in nature, acrid in the mouth, hardship.Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.Diuresis, clearing away damp-heat.Control dysuria, gonorrhea, leukorrhagia, hernia, rubella, sore, scabies, pudendum pruritus due to damp pathogen." herbal classic ": " main bladder heat, diuresis.Invigorating middle warmer, beneficial vital essence.Steam in " " not Lu ": " peeling skin, loose malignant boil, hernia abdominal mass, reinforcing YIN-essence, makes people moisten.

Fructus Rosae Laevigatae root bark obtains through refining tannic extract; Fruit medicine, has diuresis, kidney tonifying functions; Leaf has removing toxic substances and promoting subsidence of swelling effect; Root is medicinal, can promoting blood circulation to remove blood stasis, convergence of drawing out pus by applying a plaster to the affected part, dispel the wind that it is wet to drive.Fruit is containing vitamin C, malic acid, citric acid, tannin, Saponin etc.Not solid for suffering from a deficiency of the kidney, emission and spermatorrhea, the enuresis, frequent micturition, or women's profuse leukorrhea; Insufficiency of the spleen incessant chronic diarrhea, or chronic dysentery large intestine is not solid.In addition, also can be used for the empty vigour of body not solid, proctoptosis, uterine prolapse, metrorrhagia, astringing intestine to stop diarrhea, controlling nocturnal emission with astringent drugs, stopping leak dysentery, urine reducing.Fructus Rosae Laevigatae is the famous medicine of the kidney invigorating simply.The traditional Chinese medical science is thought, Fructus Rosae Laevigatae sour in the mouth, and property is put down, and enters kidney, large intestine two warp, has reinforcing the kidney and controlling nocturnal emission, effect of reducing urination and antidiarrheal.Emission and spermatorrhea can be treated, frequent urination and enuresis, leukorrhagia, metrorrhagia, spontaneous perspiration, night sweat, cough due to deficiency of the lung, insufficiency of the spleen dysentery etc.Modern pharmacology research confirms: Fructus Rosae Laevigatae extract can extend the interval between micturition time; Contained tannin has stronger inhibitory action to staphylococcus aureus, escherichia coli, bacillus pyocyaneus etc.

Galla Chinensis sour in the mouth is puckery, cold in nature.Return lung, large intestine, kidney channel.Effect: astringe the lung; Hidroschesis; Astringing intestine to stop diarrhea; Controlling nocturnal emission with astringent drugs; Hemostasis; Removing toxic substances.Cure mainly: chronic cough of deficiency lung; Spontaneous sweating; Chronic dysentery chronic diarrhea; Proctoptosis; Seminal emission; Nebulousurine; Various hemorrhage; Carbuncle furuncle.Detailed outline ": pathogenic fire reducing of astringing the lung, reduce phlegm drink, and cough-relieving is coughed, and quenches one's thirst, night sweat, and vomiting, loses blood, chronic dysentery, jaundice, cardiac and abdominal pain, and the nocturnal fretfulness in infants, controls eye red and wet rotten, and detumescence poison, sore throat, hold back routed skin ulcer, incised wound, under receiving proctoptosis, sub-intestinal pendant.

Semen Benincasae sweet in the mouth; Cold nature, returns lung; Large intestine channel.Function cures mainly removing heat from the lung and dissipating phlegm; Eliminating carbuncle evacuation of pus; Dampness removing.Main phlegm-heat cough; Lung abscess; Intestinal carbuncle; Nebulousurine; Leukorrhagia; Foot gas; Edema; Stranguria." Bencao Jingshu ": can whet the appetite the Pi that wakes up." book on Chinese herbal medicine is stated ": cure mainly heart channel intrinsic heat, little water drenches pain, and nasal surface schlempe is as numb bean, and pain, yellow fluid goes out." Bencao Congxin ": tonifying liver improving eyesight.

Semen Pharbitidis: bitter in the mouth, cold in nature, poisonous.Return lung, kidney, large intestine channel.Have removing water retention by purgation relieving constipation, drink is washed in expectorant, the function that parasite killing merit is long-pending.Semen Pharbitidis is longer than detumescence of relieving oedema or abdominal distension through diuresis or purgation, parasite killing.For edema distension, constipation and anuresis, malnutrition due to parasitic infestation is suffered from diarrhoea.Semen Pharbitidis (parched): reduce toxicity after stir-fry, the property of medicine relaxes, and exempts to hinder healthy energy, and with clearing away phlegm drink, removing food stagnancy is stagnant to be good at, and after frying, gas is fragrant, slightly function of invigorating spleen among removing food stagnancy.Can be used for dyspnea with cough due to overabundant phlegm, eating accumulation.Outer casing rupture simultaneously, quality is crisp, and enzyme is destroyed, and is easy to pulverize and fried effective ingredient, is beneficial to methods of glycosides and preserves.Have under rushing down, diuresis, detumescence, the effect such as anthelmintic, cure mainly the diseases such as limds edema, oedema due to nephritis, cirrhotic ascites, constipation, abdominal pain due to worm stagnation.

Radix Kansui bitter in the mouth; Cold in nature; Poisonous.Gui Jing: spleen channel; Lung meridian; Kidney channel; Urinary bladder channel; Large intestine channel; Small intestine meridian.Function: removing water retention by purgation by swollen, dispersing swelling and dissipating binds.Cure mainly: edema; Ascites; Prolonged fluid-retention blocked-up chest; Epilepsy; Breath with cough; Sphincter disturbance.. Materia Medica of Decoction: Radix Kansui can water flowing, and its gas directly thoroughly reach knot place." Bencao Jingshu ": Radix Kansui, its bitter in the mouth, its gas is cold and poisonous, is apt to relieve oedema or abdominal distension through diuresis or purgation.Its main large abdomen person, namely the so-called ascites of generation also.Main hernia abdominal mass abdominal distention, the edema of the face and prolonged fluid-retention again, dredging water passages anus, Xia Wushui, loose bladder stays heat, and mass at the hypochondrium generalized edema with distention of the chest and abdomen person in skin, calls all diseases and all given birth to from wet water, and water goes drink to disappear wet removing, and is pull out it also.Radix Kansui is insidious, though kind lower water dehumidifying, so can consume vital qi, thanks to exhaust body fluid.Unit deficiency of vital energy people, except typhoid fever accumulation of fluid in the chest have to except, all the other edema tympanites, the many deficiency of spleen-YIN of class, native void can not controlling the water circulation, so that aqueous vapor is spread unchecked, and namely Liu He asks that all damp-edema of cloud completely belong to spleen soil, and method answers the real soil of spleen reinforcing, diuresis of holding concurrently.Not this figure, and anticaustic Radix Kansui purgation, be heavy its void empty also.Water both went temporarily, and multiple swelling will certainly die.Must examine disease and belong to damp and hot, have drink to have water, and the people that vigour is still strong, be one can execute ear, not so trouble is not far off.

Pollen Typhae sweet in the mouth, micro-pungent; Property is put down.Return liver; The heart; Spleen channel.Effect is stopped blooding; Blood stasis dispelling; Diuresis.Effect is classified: blood-cooling hemostatic; Blood circulation and stasis-eliminating medicine.Cure mainly: spit blood; Spitting of blood; Epistaxis; Standby dysentery; Have blood in stool; Metrorrhagia; Traumatic hemorrhage; Trusted subordinate's pain; Amenorrhea is suffered from abdominal pain; Puerperal the stasis of blood pain; Dysmenorrhea; Tumbling and swelling; Blood strangury and dry pain; Leukorrhagia; Congenital deformity of the tongue; Aphtha; Ting ear; Uncontrolled urination is itched.Pollen Typhae can prevent the serum cholesterol level of feed height fat animal from increasing, and can increase the fecal cholesterol of feed hyperlipidemia rabbit.This effect, may be also relevant with affecting the metabolism of body inner cholesterol except suppression intestinal absorption cholesterol, increase fecal cholesterol.By Pollen Typhae oil, Pollen Typhae residue and Pollen Typhae pollen feed bait Rabbits With HypercholesterolemiaIn respectively, the effect for reducing blood fat of result Pollen Typhae pollen is the most obvious.Often only add Pollen Typhae 16g every day to raising with the rabbit of high lipid food, 12 Zhou Houting raise high fat, continue to take Pollen Typhae 4 weeks, and administration group not only serum cholesterol declines rapidly, within 9 weeks, namely reach normal concentration, and Cholesterol concentration in aortic tissue content reduces, and pathological changes alleviates.Arteriolar dilatation in cardiac muscle, blood flow increases, and metabolism is vigorous, and myocardial nutrition improves, and Mottling formation is less; Electron microscopic examination, visible most rabbit aorta endothelium is complete smooth, and subintima is normal, only the cellular infiltration of accidental minute quantity and lipidosis.

The Radix Rehmanniae: the Radix Rehmanniae is also Radix Rehmanniae, the fresh or dry tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch..Heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, the incised wound stasis of blood, removing heat from blood, hemostasis; The effect of Radix Rehmanniae and Radix Rehmanniae is different.Radix Rehmanniae clearing away heat and promoting production of body fluid, can stop blooding and removing heat from blood, is often for consumption of YIN caused by febrile disease, the diseases such as haematemesis, laryngopharynx swelling and pain, crimson tongue excessive thirst, a speckle dermexanthesis and nosebleed heat.Relative to Radix Rehmanniae, Radix Rehmanniae is heat clearing and blood cooling, also can promote the production of body fluid, all right yin nourishing, is used for treatment yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, crimson tongue excessive thirst, sends out the problems such as speckle dermexanthesis.The Radix Rehmanniae is cold in nature, and function is enriching yin and nourishing kidney.Not only promoting the production of body fluid to quench thirst and heat clearing and blood cooling, also have effect to metrorrhagia, menoxenia, frequent fetal movement, constipation etc., every blood system has the people of thermal burn the moon, can often take.If want to treat epidemic febrile disease, qingying decoction can be done with the Radix Rehmanniae; If the later stage for the treatment of epidemic febrile disease, because She's heat does not also disappear to the greatest extent, the Radix Rehmanniae should be used for boiling QINGHAOBIEJIATANG; In addition, contain for heat in blood poison, macule purple is black, and the serious heat of epidemic febrile disease enters the symptom of nutrient blood, can take the Sisheng Wan that the Radix Rehmanniae is made; General want YIN nourishing and the production of body fluid promoting to treat interior-heat quenches one's thirst with constipation, the once liquid soup that the Radix Rehmanniae boils should be eaten.

Fructus Ligustri Lucidi is used for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, slowly must get effect.Control poor vision, often join Radix Rehmanniae Preparata, Fructus Lycii is equal to use, controls early whitening of beard and hair, and often join the same use of Fructus Mori, fever due to yin deficiency, often joins Cortex Lycii.The hepatic and renal YIN deficiency, Light-headedness, seminal emission tinnitus, soreness of the waist and knees, early whitening of beard and hair, coronary heart disease, hyperlipemia, hypertension, chronic hepatitis.The protective effect research of liver is thought, Fructus Ligustri Lucidi contains oleanolic acid, to rat skin lower injection, serum glutamic pyruvic transminase can be reduced, there is obvious protective effect to the hepatic injury of Carbon Tetrachloride Induced, and can liver cell regeneration be promoted. oleanolic acid also can make triglyceride accumulation minimizing in liver, hepatocellular degeneration necrosis obviously alleviates, glycogen accumulation increases, serum γglobulin declines; Ultrastructure visible hepatocyte mitochondrial swelling and endosomal vesicle degeneration alleviate, hepatic tissue asks that matter inflammatory reaction weakens

The micro-hardship of Rhizoma Polygoni Cuspidati, is slightly cold.Return liver, gallbladder, lung meridian.Function with cure mainly: heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea, postnatal blood stasis does not Xia ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, traumatic injury, carbuncle sore tumefacting virus.Rhizoma Polygoni Cuspidati extract has antipyretic effect.Resveratrol glycoside and pentobarbital sodium and urethanes have synergism, can obvious Sleeping Time Prolong Ed.Huzhang has convergence to scald wound, protects from infection and antiinflammation.In addition, certain density emodin can cause small intestinal hypermyotonia, and contractive amplitude increases, and increased dosage amount then can suppress small intestinal movable.Supplement to the Herbal: main air asks about blood stasis at joint.Liquor takes it as wine." Japan hanako materia medica ": after managing property stagnant blood not under, trusted subordinate's distension.Evacuation of pus, main furuncle carbuncle poison, married woman's bruise, flutters damage blood stasis, broken pathogenic wind toxic stagnation of QI." the southern regions of the Yunnan Province book on Chinese herbal medicine ": attack all toxic swellings, only have sore throat, diuresis, walk meridians.Control five types of stranguria nebulousurine, anal fistula, carbuncle sore, married woman's leucorrhea with red and white discharge.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Poria slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, is reached by strong activating the spleen pulmonary function, different from the Chinese medicine of other direct diuretic.For diarrhea due to hypofunction of the spleen, leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.

Radix Paeoniae Rubra, clots absorbing, pain relieving, removing heat from blood, detumescence.Cure mainly: control the stagnant amenorrhea of the stasis of blood, hernia abdominal mass is gathered, suffer from abdominal pain, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle, injury from falling down.Radix Paeoniae Rubra can purify the blood a point excess-heat, and dissipating blood stasis blood is detained.This product function is close with Cortex Moutan, therefore normal and Cortex Moutan mutual reinforcement between is for use.But the effect of Cortex Moutan clearing away heat and cooling blood is better, can purify the blood a point excess-heat, can control fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for blood system excess-heat, be good at promoting blood circulation to remove blood stasis." herbal classic ": main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating.

Radix Polygoni Multiflori Preparata: Chinese medicine Radix Polygoni Multiflori have Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata point, direct slicing is used as medicine for Radix Polygoni Multiflori, dries be used as medicine for Radix Polygoni Multiflori Preparata with Semen sojae atricolor liquor after mixing steaming.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, eliminating carbuncle, loosening bowel to relieve constipation, is usually used in treatment scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; The invigorating the liver and kidney of Radix Polygoni Multiflori Preparata function, benefiting essence-blood, black beard and hair, bone and muscle strengthening, for blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void etc.Radix Polygoni Multiflori Preparata of the present invention is the good merchantable brand of invigrating kidney.

Polyporus sweet in the mouth, light, flat.Enter the heart, spleen, stomach, lung, kidney, warp.Promoting diuresis to eliminate damp pathogen.Control dysuria, edema, to have loose bowels, stranguria with turbid discharge, leukorrhagia.Polyporus is long at China's applicating history.As far back as " village " in book " pig zero " by name; Shennong's Herbal is classified as middle product.Collective Notes to the Canon of Materia medica note has: " maple Siberian cocklebur, its skin de-black makes block like pig dung, thus with name it.Meat Bai Ershi person is good, with it casting skin of pruning." amplification on Canon of Materia Medica carries: " Polyporus, the merit spirit of row water, clothes must damage kidney qi for a long time, enter order dusk "." book on Chinese herbal medicine is looked for the truth " carries: " Polyporus, the side such as all four Siberian cockleburs, five Siberian cockleburs, and all with this, though property has class Rhizoma Alismatis, with entering bladder kidney channel, antipyretic dehumidifying, row key diuretic, right water disappears then spleen must be dry, and water to the greatest extent then gas must be walked.

Herba Verbenae: the dry aerial parts " Bencao Jingshu " of Verbenaceae Herba Verbenae Verbena officinalis L.: Herba Verbenae is originally the medicine of removing heat from blood removing blood stasis.Bottom abscess person, the pole of heat in blood, furthermore damp and hot, therefore blood stains are turbid forms skin ulcer, and have worm also.The cool pyrolysis of blood, the broken and row of dirty person, waste and be not recovered.CHEN Zang-Qi calls its removing blood stasis parasite killing, also this meaning ear." China's book on Chinese herbal medicine " cures mainly cold, fever; Laryngopharynx swelling and pain; Gingival swelling and pain; Jaundice; Dysentery; Blood stasis amenorrhea; Dysmenorrhea; Lump in the abdomen; Edema; Dysuria; Malaria; Carbuncle pyogenic infections from tumour or sore; Traumatic injury.Venbenalin is excited in a small amount to SNE, suppresses in a large number; Galactopoiesis can be promoted to mammal.Heat and toxic materials clearing away medicine; Promoting blood circulation to restore menstrual flow medicine; Edema-alleviating diuretic; Preventing the attack (or recurrence) of malaria medicine; Promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, removing toxic substances, inducing diuresis to remove edema.For lump in the abdomen, amenorrhea dysmenorrhea, malaria, sore throat, carbuncle, edema, pyretic stranguria

Liver-nourishing kidney-boosting, cooling blood for hemostasis medicine that Herba Ecliptae grass is commonly used for the traditional Chinese medical science.To caused by the Light-headedness caused by the hepatic and renal YIN deficiency, odontoseisis, aching pain in waist and back, all diseases of flaccidity and weakness of the lower limbs and heat in blood multiple go out blood disorder have good efficacy.Herba Ecliptae contains the chemical compositions such as volatile oil, tannin, Saponin, Herba Ecliptae element and vitamin A.Animal experiment has haemostatic effect, and in vitro tests has inhibitory action to staphylococcus aureus.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are by the strong feature of broad-spectrum antibacterial action, are used in fungal culture miscellaneous bacteria and infect special severe, fine by Radix Scutellariae extracting solution effect." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so evil removing: bitter in the mouth is so dampness; YIN-cold is so victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, and the disease of all damp and hot victory also, analyses it, then all diseases are from recover.Bitter cold can except damp and hot, thus small intestinal profit and water from by, source is clearly then flowed also clean.The blood person of closing, excess-heat is at blood system, and instant heating human blood room, it is obstructed to make us amenorrhea, and damp and hot solution, then Ying Qi clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood then stays knot, and is that carbuncle stain is also rotten: acute scleritis person, also, removing heat from blood heat extraction, then spontaneous recovery also for fire of moxibustion blood trouble.Radix Scutellariae has antiallergic action and antiinflammatory action: the anaphylaxis contractile response that baicalin contained by Radix Scutellariae and baicalin can obviously suppress sensitized guinea pig rat small intestine in vitro and isolated tracheal to produce antigen, to passive general allergy and the Cavia porcellus passivity skin allergic reaction of Cavia porcellus and mice, baicalin and baicalin also have inhibitory action.Radix Scutellariae has refrigeration function, and most test proves, the active ingredient baicaligenin of Radix Scutellariae has refrigeration function.Radix Scutellariae has Detoxication, and baicalin has obvious Detoxication, and this may be that baicalin decomposites glucuronic acid due under the effect of glucuronidase, and caused by being combined with multiple poisonous substance.The LD50 that baicalin 10 milligrams can improve strychnine reaches 2.5 times, and the hepatic glycogen content of carbon tetrachloride poisoning mice is increased.

Herba Patriniae nature and flavor hardship is flat, has effect of heat-clearing and toxic substances removing, evacuation of pus removing blood stasis with potent drugs.Acute appendicitis, dysentery, leucorrhea with red and white discharge, the stagnant stomachache of the stasis of blood in puerperal, conjunctival congestion and swelling pain can be cured.Enter stomach, large intestine, Liver Channel.Cure mainly heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.For acute appendicitis, lung abscess and sore and toxic, the stagnant caused breast abdomen pain of the excess-heat stasis of blood, the diseases such as the stagnant stomachache of the stasis of blood in puerperal.

Containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in Herba Taraxaci plant, there are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Herba Taraxaci, simultaneously containing protein, fat, carbohydrate, trace element and vitamin etc., has abundant nutritive value, raw-eaten, stir-fry and eat, cook soup, is the plant of dietotherapeutic.Containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in Herba Taraxaci plant, there are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Herba Taraxaci containing protein, fat, carbohydrate, trace element and vitamin etc., has abundant nutritive value simultaneously.The carotene wherein contained and C and mineral, to the effect that dyspepsia, constipation are all improved.Leaf is also improved eczema in addition, the effect of dermatitis of releiving, and root then has antiinflammation, and flower decocts into medicine juice can remove freckle.

The specific embodiment of the invention

Specific embodiment 1

The preparation of capsule of the present invention: get Semen Vaccariae 1000g, Fructus Kochiae 1000g, Fructus Rosae Laevigatae 1000g, Galla Chinensis 1000g, Semen Benincasae 1000g, Semen Pharbitidis (parched) 1000g, Radix Kansui 1000g, Radix Rehmanniae 1000g, Rhizoma Polygoni Cuspidati 1000g, Radix Polygoni Multiflori Preparata 1000g, Poria 1000g, Radix Paeoniae Rubra 1000g, Radix Salviae Miltiorrhizae 1000g, Semen Abutili 1000g, Polyporus 1000g, Herba Verbenae 1000g, Radix Scutellariae 1000g, Fructus Ligustri Lucidi 1000g, Herba Ecliptae 1000g, Herba Patriniae 1000g, Herba Taraxaci 1000g.Get above-mentioned raw materials medicine to add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, removes supernatant after leaving standstill, and then 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, stand for standby use, becomes component 1.The medicinal residues of the crude drug crossed by above-mentioned ethanol extraction add 10 times of water gagings, heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill; Above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.08; Being concentrated into relative density is 1.20, and the extractum of temperature to 60 DEG C-70 DEG C, stand for standby use, becomes component 2.Merged by the extractum of component 1 and component 2, then put into concentrating under reduced pressure tank, being evaporated to relative density is 1.20, then takes out, and puts into drying machine drying powdered, puts into capsule, becomes capsule.

Specific embodiment 2

The preparation of the present invention's honey refining pill:

Get Semen Vaccariae 1200g, Fructus Kochiae 1300g, Fructus Rosae Laevigatae 1200g, Galla Chinensis 1200g, Semen Benincasae 1200g, Semen Pharbitidis (parched) 1200g, Radix Kansui 1200g, Radix Rehmanniae 1200g, Rhizoma Polygoni Cuspidati 1100g, Radix Polygoni Multiflori Preparata 1200g, Poria 1200g, Radix Paeoniae Rubra 1200g, Radix Salviae Miltiorrhizae 1200g, Semen Abutili 1200g, Polyporus 1200g, Herba Verbenae 1200g, Radix Scutellariae 1200g, Fructus Ligustri Lucidi 1300g, Herba Ecliptae 1200g, Herba Patriniae 1100g, Herba Taraxaci 1200g.By the roguing of above-mentioned component crude drug, dry, be ground into granule, soak 1 hour; Soaked raw material is put in multi-function extractor and decocts with water secondary; Add up the water of medical material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of total amount 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters; The filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, convection drying powdered; Then add Mel and be twisted into pill

Specific embodiment 3

The preparation of oral solutions of the present invention:

Get Semen Vaccariae 1100g, Fructus Kochiae 1200g, Fructus Rosae Laevigatae 1100g, Galla Chinensis 1200g, Semen Benincasae 1200g, Semen Pharbitidis (parched) 1200g, Radix Kansui 1200g, Radix Rehmanniae 1200g, Rhizoma Polygoni Cuspidati 1100g, Radix Polygoni Multiflori Preparata 1200g, Poria 1200g, Radix Paeoniae Rubra 1200g, Radix Salviae Miltiorrhizae 1200g, Semen Abutili 1200g, Polyporus 1300g, Herba Verbenae 1300g, Radix Scutellariae 1100g, Fructus Ligustri Lucidi 1200g, Herba Ecliptae 1200g, Herba Patriniae 1200g, Herba Taraxaci 1200g.The medicine of crude drug is put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then put into concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06 extractum, become component 2.By component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

Specific embodiment 4

The preparation of Tablets:

Get Semen Vaccariae 1300g, Fructus Kochiae 1200g, Fructus Rosae Laevigatae 1100g, Galla Chinensis 1200g, Semen Benincasae 1200g, Semen Pharbitidis (parched) 1200g, Radix Kansui 1200g, Radix Rehmanniae 1300g, Rhizoma Polygoni Cuspidati 1100g, Radix Polygoni Multiflori Preparata 1200g, Poria 1200g, Radix Paeoniae Rubra 1200g, Radix Salviae Miltiorrhizae 1200g, Semen Abutili 1200g, Polyporus 1300g, Herba Verbenae 1300g, Radix Scutellariae 1200g, Fructus Ligustri Lucidi 1200g, Herba Ecliptae 1300g, Herba Patriniae 1200g, Herba Taraxaci 1200g.First Semen Vaccariae, Fructus Rosae Laevigatae steam method are distilled according to described number, obtain crystal, for subsequent use as component 1; Get the 60-90% soak with ethanol 1-2 hour that the medicinal residues mixing surplus stock after distillation adds 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, concentrated solution is settled into extractum shape, mass continues heating and is concentrated into extractum shape, stand for standby use, becomes component 2; The component 1 of distillation extraction and the component 2 of ethanol extraction are mixed, tablet made by tabletting.

Pharmacological toxicity is tested

One, test material:

(1) laboratory animal: mouse NIH, body weight 25-28g, male and female half and half; Rats Wistar body weight 130-160g, male and female half and half, the feedstuff of rat, mice is provided by Shandong medical college animal experimental center.

(2) test medicine:

1, medicine of the present invention: the pill that embodiment 2 is made, applies with distilled water diluting during three batch equal amount of mixture experiments.

2, positive control medicine: JINGUI SHENQI WAN, commercially available.

Two, test method and result:

(1) get the healthy mice 80 of body weight 25-28g, female, hero half and half, is divided into four groups respectively by sex and body weight, often organizes 20.1, take medicine of the present invention for 2,3 groups, dosage is respectively 8.6g crude drug/kg/d, 6.4g crude drug/kg/d, 4.2g crude drug/kg/d, and take positive control drug JINGUI SHENQI WAN for the 4th group, dosage is 6g crude drug/kg/d, is used in conjunction 15 days.

Result of the test: 1,2,3 groups of mices obviously strengthen than 4 groups of mice sexual excitation degree, the number of copulations of 1,2,3 group of mice average every day increases by 3 times than the number of copulations of 4 groups of mices.

Result of the test shows that medicine of the present invention has obvious excitation to central nervous system, thus medicine of the present invention for adjustment human body function equilibrium, QI invigorating, enrich blood, slow down aging strengthens metabolism, neurolysis, sexual hypofunction has treatment foundation.

Animal acute toxicity test of the present invention

One, test material

(1) animal mouse NIH kind male and female half and half, body weight 20-22g, are provided by Shandong medical college Animal Lab..

(2) test medicine: the oral liquid that the present invention is made, is diluted with distilled water into suspension.

Two, test method and result:

Mice maximum tolerance determination: get healthy mice 32, male and female half and half, divided three groups within 24 hours, and only, gross weight 1.8ml, is equivalent to crude drug in whole 4.0g to each 0.6ml/ of gavage intestinal, i.e. 100g crude drug/kg/d, is equivalent to 857 times of clinical 65 kilograms of people.After mice administration routinely feedstuff within 12 days, have no animal dead and do not go out, existing toxic reaction.Therefore prove, medicine of the present invention has no side effect, and clinical practice is safe and reliable.

The long-term toxicity test for animals of pharmaceutical composition of the present invention

One, test material and method

(1) test medicine: the tablet that the embodiment of the present invention is made.

(2) laboratory animal, healthy rat Wistar, body weight 100-130g, 140 male and female half and half, by sex and body weight random packet, four groups, often organize 35.1, take test medicine for 2,3 groups, dosage is respectively 9.6/kg/d, 6.4/kg/d, 3.2/kg/d.4 groups contrast to the distilled water of respective volume amount, the equal gavage enteral administration of rat, often organize and be once used in conjunction 6 months, put to death half, and under She, all death in 12 days is observed in 1/2 drug withdrawal.

Two, test index

(1) general status comprises body weight, diet, emotion, movable energy.

(2) hemogram checking: red blood cell count(RBC), numeration of leukocyte, platelet count, hemogram etc., quantitative hemoglobin counts.

(3) biochemical analysis, serum albumin quantitatively, cholesterol, blood sugar quantitative.

(4) pathologic diagnosis: get half animal after experimental result and weigh, sacrificed by decapitation, gets blood, solution is treated others for earnest simultaneously, liver, kidney, lung, brain, spleen, gastrointestinal, bladder, adrenal gland do pathologic diagnosis.

Three, result of the test: show through rat chronic toxicity test, with the heavy dose of coloclysis of the present invention six months, increases the growth of rat, body weight, all has no side effect to brain, Liver and kidney function.Do not find that infringement changes to each histoorgan of rat, blood circulation, medication group compares no significant difference with matched group.Illustrate that medicine of the present invention has warming and recuperating the kidney-YANG, QI invigorating, enriches blood, slow down aging strengthens the drug effects such as metabolism, avirulence.

Medicine and clinical experiment

Urinary system infection is commonly encountered diseases clinically, refers to that various pathogenic microorganism grows in urinary tract, breeding and the urinary tract infection disease that causes, is more common in Women of Childbearing Age, old people, hypoimmunity and urinary tract deformity person.Select rational Drug therapy very necessary.Plan prescription and the clear granule of hot woods are certainly chosen in this experiment, and [authentication code is: the accurate word Z52020383 of traditional Chinese medicines, contrast, prove the pure Chinese medicinal preparation of the present invention's development, there is effect of heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, be widely used in the treatment of the diseases such as urgent, chronic nephropyeltis, cystitis, urethritis clinically.Now the Ureteral Calculus that 40 routine urinary system infection patients observe in my section is summarized as follows:

1. data and method

1.1 physical data: from JIUYUE, 2012 to December, my section selects the urinary system infection patient 40 example clear granule therapy of hot woods altogether, man 25 example, female 15 example, 34 years old mean age.All come the Urology Department outpatient service of self-institute or inpatient.Patient all has typical urinary tract infection symptom (frequent micturition, urgent micturition, dysurea) and (or) kowtows pain, routine urianlysis leukocyte meter > 5/HP with lumbago, hematuria, heating and kidney district; And get CCMS antibacterial culturing, Urine culture bacteria colony count > 10 ⁵ml.Chinese medical discrimination is stranguria: damp-heat in lower-JIAO, frequent micturition, frequent micturition, urethra scorching hot, puckery pain, urine yellow red or companion lumbago, abdomen pain, heating, aversion to cold, yellowish fur, wiry and frequent pulse etc.Treat the antibacterials that the previous moon did not use other.

Following situation is not as treatment target: 1. not by regulation medication and cannot judge the full person of curative effect or data; 2. edge design women or have the complete and cachexia person of severe cardiac, Liver and kidney function; 3. the urinary disorders such as urethra symptom group, tuberculosis of urinary system, acute and chronic nephritis; 4. the age was under-18s and more than 70 years old, allergic constitution person; 5. there is hyperpyrexia, kidney district kowtows the obvious acute pyelonephritiss of General Symptoms such as pain; 6. x line radiography confirms have the distortion of renal pelvis renal calices, the irregular chronic pyelonephritis even not reducing person of kidney shadow; 7. gonorrhea; 8. urinary system pathology dissect physiology is associated with abnormal as urinary tract obstruction, foreign body, VUR and neurogenic bladder function obstructor; 9. anti-infectives and other associated treatment was used in selected first 7 days; 1. participate in the patient of other clinical trials and participate in the medical personnel of this test.

By medical precedence, patient is divided into treatment group and matched group two groups at random, each 20 examples.After urinary system infection is made a definite diagnosis, give particulate oral clear with patient Re Lin, the oral Chinese medicine preparation of the present invention for the treatment of group patient, the matched group patient clear granule of oral hot woods and norfloxacin, wherein in treatment group, merge lithangiuria 3 example, in matched group, merge lithangiuria 3 example.

1.2 clinical trial protocols:

1.2.1 medication: clinical research adopts method that is random, parallel control, and the ratio for the treatment of group and matched group is 1:1.Treatment group Chinese medicine preparation of the present invention, makes granule (preparing by the method for embodiment 1), matched group Relinqing Granula, adds with norfloxacin capsule; For the compliance of experimenter, the work of experimenter must be carried out, make the meaning of its apprehension test, persuade its household to supervise and take medicine according to quantity on time, and further consultation on request.

1.2.2 the course for the treatment of: 7-10 days.Namely all optant's of entering completed treatments carry out statistical analysis and clinical summary, treat in first 1 week and use antibiotic person not include research in.

1.2.3 observation item: clinical symptoms, sign and routine blood test, routine urinalysis, urine cultivation results before and after record treatment; Relevant untoward reaction after recording medicine.

1.3 efficacy assessment standards: the guideline of clinical investigations issuing " antibacterials clinical research guidance standard " and < new Chinese medicine guideline of clinical investigations > (second volume) relevant new Chinese medicine treatment urinary system infection according to Ministry of Public Health for 1993 is drafted.

1.3.1 lab testing and etiological examination evaluation curative effect: recovery from illness: symptom, sign, lab testing and etiological examination 4 recover normal; Effective: the state of an illness is clearly better, but in above-mentioned four, have 1 not recover normal completely; Effective: after medication, the state of an illness takes a turn for the better to some extent, but obvious not; Invalid: medication after 72 hours the state of an illness without obviously progressive or add severe one to some extent.Recovery from illness+effective, does clinical effective calculating; Effectively+and invalid, make invalid computation.

1.3.2 tcm syndrome comprehensive therapeutic effect is observed: recovery from illness: clinical symptom disappearance or substantially disappear; Effective: clinical symptoms is obviously improved; Effective: clinical symptoms takes a turn for the better; Invalid: clinical symptoms is improved not obvious.

2. result

2.1 liang of group Clinical efficacy comparisons, (see table 1).

Table 1 Capsules group of the present invention and Relinqing Granula add norfloxacin group Clinical efficacy comparison

After 2.2 treatments, two groups of symptoms, sign extinction times compare, (see table 2).

Table 2 liang group symptom, sign extinction time compare (my god)

From (table 1): two groups of comparitive study, through Ridit inspection, P < 0.05, the clear granule of hot woods adds norfloxacin group cure rate and total effective rate is all significantly higher than alone norfloxacin group.From (table 2): two groups are compared, t checks, and P < 0.01, Relinqing Granula adds norfloxacin group urinary tract infection symptom: lumbago, hematuria, heating, and the extinction time of percussion tenderness over kidney region is obviously longer than Capsules group of the present invention.

2.3 liang of group bacteria clearance compare.The present invention treats front CCMS positive bacterial culture 13 example (comprising escherichia coli 11 example, staphylococcus epidermidis 1 example, Bacillus proteus I example), and after treatment, 9 routine antibacterials are eliminated, and bacteria clearance is 69.2% (9/13).

Before Relinqing Granula adds the treatment of norfloxacin group, after CCMS positive bacterial culture 13 example (comprising escherichia coli 12 example, Bacillus proteus 1 example) treatment, 12 routine antibacterials are eliminated, and bacteria clearance is 92.3 (12/13).

The difference of two groups of bacteria clearance is through the inspection of fisher exact propability, and P < 0.05, thinks that Relinqing Granula adds norfloxacin group bacteria clearance and is better than alone of the present invention group.

The comparison of 2.4 untoward reaction.In of the present invention group, adverse reaction rate is 10% (2/20), shows as nauseating 1 example, vomiting 1 example; Relinqing Granula adds in norfloxacin group, and adverse reaction rate is 5% (1/20), shows as stomach discomfort.Before and after treatment, two groups of patients are showed no in Peripheral blood and obviously decline and the infringement of hepatic and renal function from cell counting.The difference of two groups of untoward reaction rates is significance (P > 0.05) through fisher exact propability inspection difference.

3. discuss

The present invention has effect of heat-clearing and toxic substances removing, anti-inflammation, inducing diuresis for treating stranguria syndrome, promoting blood circulation and detumescence, is usually used in the treatments such as urgent, chronic nephropyeltis, cystitis, urethritis, lithangiuria, prostatitis, vaginitis, pelvic inflammatory disease, cervicitis, gonorrhea and sexually transmitted disease (STD) sequela.Pharmacological evaluation has excellent antibacterial action to Gram-positive, negative bacterium such as staphylococcus aureus, escherichia coli, Bacillus typhi, dysentery bacterium, bacillus pyocyaneus, Bacillus proteus, gonococcuss.This group is observed and is found that this medicine has remarkable auxiliary curative effect effect in clinical treatment urinary tract infection.Alone of the present invention group of cure rate is 73.3%, and Relinqing Granula and norfloxacin share treatment group cure rate is 93.3%, and total effective rate is 95%.In addition, the result of this group also shows, and uses the present invention obviously can shorten the extinction time of urinary tract infection symptom and sign, and can improve bacteria clearance; Itself and norfloxacin use in conjunction produce synergism, can be used as a kind of active drug for the treatment of urinary tract infection.Meanwhile, use the present invention to treat urinary tract infection, can avoid using antibiosis rope and the shortcomings such as the fastbacteria that causes increases, dysbacteriosis and infringement hepatic and renal function because of long-term, a large amount of, in Clinical practice, not find obvious toxic and side effects.

The present invention is a kind of pure Chinese medicinal preparation, and for brown to dark brown speckles, fragrant odour, peroral dosage form, Clinical practice is convenient, and patient compliance is better, is worth of widely use.In addition, the present invention is Sugarless type, to diabetics, particularly applicable.

Specific embodiment

Example 1: Wang, man, 33 years old, order first visit August 12 in 2010.Aversion to cold, heating before three days, frequent micturition is short red, and drench the puckery pain of drop, certain hospital outpatient routine urianlysis shows: erythrocyte (++), leukocyte (+++).Be diagnosed as acute urinary system to infect.With treatments such as antibiotic.Existing cold and heat are not obvious, and frequent micturition, urgent micturition, Urethra astringent pain do not subtract, xerostomia, red tongue, yellow, greasy and thin fur, stringy,thready and rapid pulse.Prescription: Semen Vaccariae 12g, Fructus Kochiae 11g, Fructus Rosae Laevigatae 12g, Galla Chinensis 12g, Semen Benincasae 13g, Semen Pharbitidis (parched) 12g, Radix Kansui 12g, Radix Rehmanniae 12g, Rhizoma Polygoni Cuspidati 11g, Radix Polygoni Multiflori Preparata 12g, Poria 12g, Radix Paeoniae Rubra 11g, Radix Salviae Miltiorrhizae 12g, Semen Abutili 12g, Polyporus 13g, Herba Verbenae 12g, Radix Scutellariae 12g, Fructus Ligustri Lucidi 13g, Herba Ecliptae 11g, Herba Patriniae 12g, Herba Taraxaci 11g, takes 14 days and recovers, after visit and have no recurrence.Card belong to from the beginning of, therefore heat-clearing and toxic substances removing, relieving stranguria by diuresis and tonifying the kidney to reduce urination, YIN nourishing increases advances side by side night.

Example 2: go into business certain, man, 45 years old, first visit on March 16 in 2011.Occurred hematuria before March, sometimes accompany fast shape thing, the involved and abstruse twinge of urine, lower abdominal distention pain, urgently has a pain.Certain hospital's cystography is diagnosed as papilloma of bladder, and when examining, expression is painful, becomes thin, stringy pulse, dimly red tongue.Prescription: Semen Vaccariae 11g, Fructus Kochiae 11g, Fructus Rosae Laevigatae 12g, Galla Chinensis 12g, Semen Benincasae 13g, Semen Pharbitidis (parched) 12g, Radix Kansui 13g, Radix Rehmanniae 12g, Rhizoma Polygoni Cuspidati 11g, Radix Polygoni Multiflori Preparata 12g, Poria 12g, Radix Paeoniae Rubra 12g, Radix Salviae Miltiorrhizae 12g, Semen Abutili 12g, Polyporus 13g, Herba Verbenae 12g, Radix Scutellariae 12g, Fructus Ligustri Lucidi 13g, Herba Ecliptae 11g, Herba Patriniae 12g, Herba Taraxaci 11g, 10 doses.Two examine (March 26): top clothes, to 5 doses, are discharged volume block (microscopy system sludged blood) all diseases in patient's urine and are clearly better.This routine stranguria with blood is caused by tumor of bladder.First visit with cooling blood for hemostasis, blood circulation and removing stasis, heat-clearing and toxic substances removing is main; The stasis of blood is gone then with cooling blood for hemostasis, and flat spleen reinforcing kidney is for wanting.January is taken altogether, symptom complete incidence graph before and after this example.

Example 3: pay certain, man, 42 years old, workman.First visit on April 10 in 2010.Readme burst left side lumbar severe pain, pain draws pudendum, and urine is not smooth, and be sometimes with blood, certain hospital x line plain abdominal radiograph, is diagnosed as ureteral calculus.Today, waist abdomen severe pain was done again, and urine is not smooth, and short urination is red, xerostomia, red tongue, yellow and greasy fur, wiry and rapid pulse.Prescription: Semen Vaccariae 13g, Fructus Kochiae 12g, Fructus Rosae Laevigatae 12g, Galla Chinensis 12g, Semen Benincasae 13g, Semen Pharbitidis (parched) 12g, Radix Kansui 13g, Radix Rehmanniae 12g, Rhizoma Polygoni Cuspidati 11g, Radix Polygoni Multiflori Preparata 12g, Poria 12g, Radix Paeoniae Rubra 12g, Radix Salviae Miltiorrhizae 12g, Semen Abutili 12g, Polyporus 13g, Herba Verbenae 11g, Radix Scutellariae 12g, Fructus Ligustri Lucidi 13g, Herba Ecliptae 11g, Herba Patriniae 12g, Herba Taraxaci 11g, take to 10 doses, discharge the calculus of Semen phaseoli radiati size, continue to take 10 doses and recover.Press: this routine stranguria caused by urinary stone disease belong to from the beginning of, card feelings are true, close expel the heat-evil removing blood stasis and get effect with Tonglin Paishi.

Claims (10)

1. treat the Chinese medicine preparation of pyretic stranguria for one kind, it is characterized in that, the parts by weight of described Chinese medicine preparation crude drug comprise: Semen Vaccariae 10 ~ 20 parts, the Fructus Kochiae 10 ~ 20 parts, Fructus Rosae Laevigatae 10 ~ 20 parts, Galla Chinensis 10 ~ 20 parts, Semen Benincasae 10 ~ 20 parts, Semen Pharbitidis (parched) 10 ~ 20 parts, Radix Kansui 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Paeoniae Rubra 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Semen Abutili 10 ~ 20 parts, Polyporus 10 ~ 20 parts, Herba Verbenae 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Herba Ecliptae 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts.

2. treat the Chinese medicine preparation of pyretic stranguria according to claim 1, it is characterized in that, the parts by weight of described Chinese medicine preparation crude drug comprise: Semen Vaccariae 10 ~ 15 parts, the Fructus Kochiae 10 ~ 15 parts, Fructus Rosae Laevigatae 10 ~ 15 parts, Galla Chinensis 10 ~ 15 parts, Semen Benincasae 10 ~ 15 parts, Semen Pharbitidis (parched) 10 ~ 15 parts, Radix Kansui 10 ~ 15 parts, 10 ~ 15 parts, the Radix Rehmanniae, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, Radix Polygoni Multiflori Preparata 10 ~ 15 parts, 10 ~ 15 parts, Poria, Radix Paeoniae Rubra 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Semen Abutili 10 ~ 20 parts, Polyporus 10 ~ 20 parts, Herba Verbenae 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Herba Ecliptae 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts.

3. treat the Chinese medicine preparation of pyretic stranguria according to claim 1, it is characterized in that, the parts by weight of described Chinese medicine preparation crude drug comprise: Semen Vaccariae 10 ~ 20 parts, the Fructus Kochiae 10 ~ 20 parts, Fructus Rosae Laevigatae 10 ~ 20 parts, Galla Chinensis 10 ~ 20 parts, Semen Benincasae 10 ~ 20 parts, Semen Pharbitidis (parched) 10 ~ 20 parts, Radix Kansui 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Paeoniae Rubra 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Semen Abutili 10 ~ 15 parts, Polyporus 10 ~ 15 parts, Herba Verbenae 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, Herba Ecliptae 10 ~ 15 parts, Herba Patriniae 10 ~ 15 parts, Herba Taraxaci 10 ~ 15 parts.

4. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicine preparation of pyretic stranguria, it is characterized in that, the preparation process of described Chinese medicine preparation comprises:

A, get crude drug and put into ethanol and soak, heat is extracted 2 times, and becoming paste, is component 1;

B, medicinal residues extracting in water 2 times, thickening filtration is paste, is component 2;

C, above-mentioned two kinds of pastes to be merged, be condensed into powder and incapsulate.

5. treat the preparation method of the Chinese medicine preparation of pyretic stranguria according to claim 4, it is characterized in that, in described step a, get crude drug to add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, stand for standby use, becomes component 1.

6. treat the preparation method of the Chinese medicine preparation of pyretic stranguria according to claim 4, it is characterized in that, in described step b, the medicinal residues of the crude drug that above-mentioned ethanol extraction is crossed add 10 times of water gagings, 2 extracting solution each 1 ~ 2 hour, are merged and leave standstill by heating and refluxing extraction 2 times; Above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.08; Being concentrated into relative density is 1.20, and the extractum of temperature to 60 DEG C-70 DEG C, stand for standby use, becomes component 2.

7. treat the preparation method of the Chinese medicine preparation of pyretic stranguria according to claim 4, it is characterized in that, in described step c, merged by the extractum of component 1 and component 2, then put into concentrating under reduced pressure tank, being evaporated to relative density is 1.20, then take out, put into drying machine drying powdered, put into capsule, become capsule.

8. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicine preparation of pyretic stranguria, it is characterized in that, the dosage form of described preparation is pill, and preparation method comprises:

By the roguing of described component crude drug, dry, be ground into granule, soak 1 hour; Soaked raw material is put in multi-function extractor and decocts with water secondary; Add up the water of medical material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of total amount 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters; The filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, convection drying powdered; Then add Mel and be twisted into pill.

9. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicine preparation of pyretic stranguria, it is characterized in that, the dosage form of described preparation is that the preparation method of tablet comprises the following steps:

First Semen Vaccariae, Fructus Rosae Laevigatae steam method are distilled according to described number, obtain crystal, for subsequent use as component 1; Get the 60-90% soak with ethanol 1-2 hour that the medicinal residues mixing surplus stock after distillation adds 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, concentrated solution is settled into extractum shape, mass continues heating and is concentrated into extractum shape, stand for standby use, becomes component 2; The component 1 of distillation extraction and the component 2 of ethanol extraction are mixed, tablet made by tabletting.

10. according to any one of claim 1 ~ 9, treat the Chinese medicine preparation of pyretic stranguria, it is characterized in that, the dosage form of described preparation is: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation, solution or injection.