CN103656355A - Drug for curing pig paratyphus and preparation method thereof - Google Patents
Drug for curing pig paratyphus and preparation method thereof Download PDFInfo
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Abstract
The invention discloses drug for curing pig paratyphus and a preparation method thereof. The drug comprises the following crude drugs: ophiopogon root, scutellaria root, barn grass, bombax flower, Chinese ephedra, jaca, testa dolichoris, arctium fruit, ash bark, nitraria, alfalfa, corn, areca, coix seed, poria with hostwood, red bean, shrubalthea bark, pepper, white fungus, quisqualis fruit, musk and thin evodia. The drug takes the therapeutic principles of strengthening the body resistance to eliminate pathogenic factors, clearing heat, nourishing yin, relieving inflammation and alleviating pain, and has the advantages of obvious curative effect on pigs with paratyphus, treating both symptoms and root causes, strengthening the body resistance to eliminate pathogenic factors, high cure rate, small toxic and side effects, uneasiness in relapse and low cost.
Description
Technical field
The present invention relates to herbal medicine technical field, particularly a kind of medicine that is used for the treatment of swine paratyphoid and preparation method thereof.
Background technology
Swine paratyphoid (claiming again porcine salmonellosis) is by Salmonella antibacterial, to be caused a kind of infectious disease of piglet.Acute person is with septicemia, and chronic person is with necrotic enteritis, sometimes take Catarrhal or be feature in cheese pneumonia.Cause of disease is mainly Salmonella choleraesuls and moscow' typhisuis.Salmonella typhimurium, Dare also often cause primary disease in order to do Salmonella and Salmonella enteritidis etc.Salmonella is Gram-negative, the blunt circle in two ends, oval dialister bacterium, does not form brood cell, and amphitrichous can move.This bacterium has stronger resistance to environmental factorss such as dry, corruption, daylight, in water, can survive 2～3 weeks, in feces, can survive 1～2 month, in freezing soil, can survive and pass the winter, though can only survive 4～6 weeks at the warm place of humidity, at dry place, can keep the vigor of 8～20 weeks.This bacterium is not strong to hot resistance, and 60 ℃ can be killed for 15 minutes.Also not strong to the resistance of various chemosterilants, routine disinfection medicine and typical concentrations thereof all can reach the object of sterilization.
Sick pig and the pig that carries disease germs are the main sources of infection, can be from fetus, afterbirth and the amniotic fluid discharge of bacteria of excrement, urine, milk and miscarriage.Primary disease is mainly through digestive tract infection.Copulation or artificial insemination also can be infected.Also PI in uterus.According to another report, it is quite general that health is raiseeed carry disease germs (particularly Salmonella typhimurium), when affected by extraneous undesirable element and animal resistance declines, often causes autogenous infection.Primary disease mainly encroach on 6 the monthly age following piglet, especially with 1～4 the monthly age piglet multiple.6 the monthly age above piglet seldom fall ill.Primary disease all can occur throughout the year, but overcast and rainy wet season is multiple.
Primary disease incubation period is a couple of days, or reaches the several months, relevant with quantity, the virulence of pig body resistance and antibacterial.Divide clinically acute, subacute and chronic three types.Acute: claim again septic, the multiple piglet that is born in ablactation front and back, normal sudden death.The course of disease is elder slightly, performance fervescence (41～42 ℃), and stomachache, dysentery, dyspnea, under the basal part of the ear, front and abdomen, skin has purpura, mainly with death, comes to an end.The course of disease 1～4 day.Subacute and chronic type: be commonly encountered diseases type.Performance fervescence, the inflammation of eye conjunctiva, has purulent secretion.After just constipation, suffer from diarrhoea, ash discharge white or yellow green stench feces.Sick pig becomes thin, and skin has crust shape eczema.The course of disease continues to reach several weeks, and end is to death or become cad pig.Acute: acute is changed to feature with septicemia.Corpse fat degree is normal, and portion's skins such as ear, abdomen, the side of body are visible congestion or hemorrhage sometimes, and have jaundice.Whole body serous coat, (larynx, bladder etc.) mucosa have ecchymosis.Splenomegaly, hard like rubber, tangent plane is bluish violet.The enlargement of mesenteric lymph node strand, the also enlargement in various degree of other lymph nodes of whole body, tangent plane is marble sample.Liver, renomegaly, hyperemia and hemorrhage, gastrointestinal mucosa catarrhal inflammation.Subacute type and chronic type: take necrotic enteritis as feature, common caecum, colon, involve ileum back segment sometimes.On intestinal mucosa, be covered with the rotten milk of one deck lark, peel off by force and expose the not whole ulcer surface in redness, edge.As folliculus, around mucosa is downright bad, often forms concentric colyliform ulcer surface.Mesentery lymph strand is swollen, some caseous necrosises.Spleen is enlargement slightly, and liver has visible lark necrosis region.Sometimes lung generation chronic catarrhal inflammation, and have yellow cheesy tuberosity.
The at present treatment of swine paratyphoid disease adopts more: oxytetracycline is oral, every day every kg body weight 50-100 milligram, minute 2-3 time is oral, or 40 milligrams of every kg body weight, 1 intramuscular injection; Or neomycin is oral, dosage is every kg body weight 40-50 milligram everyday, and minute 2-3 time oral.
The shortcoming of Western medicine is that side effect is relatively large, is not suitable for long-term taking, and be also not suitable for used as health medicine more, and some medicines easily produce drug resistance or Drug resistance.And Chinese medicine has no side effect, without Drug resistance, its role is to, the QI and blood of conditioning human body, smooth the liver and regulate the spleen, metabolic function and the immunologic function of adjusting body, have again antivirus action, therefore body recovery is fast, more after, not recurring, is the problem of the concentrated research of many veterinary work persons in recent years by herbal control swine paratyphoid.
The Chinese medicine of developing at present be not as good as Western medicine, therefore has report that Western medicine and Chinese medicine composition are used to the treatment curative effect of swine paratyphoid, though it has advantages of relative low price, effective speed is slower, when medicine time is longer, just can make transference cure.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of medicine that is used for the treatment of swine paratyphoid, can overcome the various defects of Chinese medicine of the prior art and Western medicine, to suffering from the piglet treatment of primary disease, have evident in efficacy, treating both the principal and secondary aspects of a disease, strengthening vital QI to eliminate pathogenic factors, cure rate is high, and toxic and side effects is little, be difficult for recurrence, the advantage that cost is low.
In order to realize foregoing invention object, the invention provides a kind of medicine that is used for the treatment of swine paratyphoid, described medicine comprises following crude drug: Radix Ophiopogonis, Radix Scutellariae, BAIMI, Flos Bombacis Malabarici, Herba Ephedrae, Fructus Artocarpi Heterophylli, Testa dolichoris, Fructus Arctii, Cortex Fraxini, Cortex Acanthopanacis Radicis, Herba Medicaginis, Semen setariae, Semen Arecae, Semen Coicis, Poria cum Radix Pini, Semen Phaseoli, Cortex Hibisci, Fructus Piperis, Tremella, Fructus Quisqualis, Moschus and Foliumet Ramulus Evodiae.
Described medicine is comprised of the crude drug of following ratio of weight and number: Radix Ophiopogonis 10-30 weight portion, Radix Scutellariae 10-20 weight portion, BAIMI 15-30 weight portion, Flos Bombacis Malabarici 10-20 weight portion, Herba Ephedrae 10-15 weight portion, Fructus Artocarpi Heterophylli 10-20 weight portion, Testa dolichoris 10-20 weight portion, Fructus Arctii 10-20 weight portion, Cortex Fraxini 15-30 weight portion, Cortex Acanthopanacis Radicis 15-30 weight portion, Herba Medicaginis 15-25 weight portion, Semen setariae 10-30 weight portion, Semen Arecae 10-20 weight portion, Semen Coicis 10-30 weight portion, Poria cum Radix Pini 10-20 weight portion, Semen Phaseoli 10-20 weight portion, Cortex Hibisci 10-20 weight portion, Fructus Piperis 10-20 weight portion, Tremella 10-20 weight portion, Fructus Quisqualis 10-20 weight portion, Moschus 10-25 weight portion and Foliumet Ramulus Evodiae 15-25 weight portion.
Described medicine is preferably comprised of the crude drug of following ratio of weight and number: Radix Ophiopogonis 21 weight portions, Radix Scutellariae 15 weight portions, BAIMI 21 weight portions, Flos Bombacis Malabarici 15 weight portions, Herba Ephedrae 13 weight portions, Fructus Artocarpi Heterophylli 15 weight portions, Testa dolichoris 15 weight portions, Fructus Arctii 15 weight portions, Cortex Fraxini 23 weight portions, Cortex Acanthopanacis Radicis 22 weight portions, Herba Medicaginis 20 weight portions, Semen setariae 20 weight portions, Semen Arecae 15 weight portions, Semen Coicis 20 weight portions, Poria cum Radix Pini's 15 weight portions, Semen Phaseoli 15 weight portions, Cortex Hibisci 15 weight portions, Fructus Piperis 13 weight portions, Tremella 15 weight portions, Fructus Quisqualis 13 weight portions, Moschus 17 weight portions and Foliumet Ramulus Evodiae 21 weight portions.
Described medicine also comprises: Pericarpium Citri Reticulatae, Ganoderma, Bulbus Allii, Fructus Jujubae and Fructus Crataegi.
Described medicine is comprised of the crude drug of following ratio of weight and number: Radix Ophiopogonis 10-30 weight portion, Radix Scutellariae 10-20 weight portion, BAIMI 15-30 weight portion, Flos Bombacis Malabarici 10-20 weight portion, Herba Ephedrae 10-15 weight portion, Fructus Artocarpi Heterophylli 10-20 weight portion, Testa dolichoris 10-20 weight portion, Fructus Arctii 10-20 weight portion, Cortex Fraxini 15-30 weight portion, Cortex Acanthopanacis Radicis 15-30 weight portion, Herba Medicaginis 15-25 weight portion, Semen setariae 10-30 weight portion, Semen Arecae 10-20 weight portion, Semen Coicis 10-30 weight portion, Poria cum Radix Pini 10-20 weight portion, Semen Phaseoli 10-20 weight portion, Cortex Hibisci 10-20 weight portion, Fructus Piperis 10-20 weight portion, Tremella 10-20 weight portion, Fructus Quisqualis 10-20 weight portion, Moschus 10-25 weight portion, Foliumet Ramulus Evodiae 15-25 weight portion, Pericarpium Citri Reticulatae 15-30 weight portion, Ganoderma 15-25 weight portion, Bulbus Allii 10-15 weight portion, Fructus Jujubae 15-35 weight portion and Fructus Crataegi 15-25 weight portion.
Described medicine is preferably comprised of the crude drug of following ratio of weight and number: Radix Ophiopogonis 15-25 weight portion, Radix Scutellariae 15-20 weight portion, BAIMI 20-30 weight portion, Flos Bombacis Malabarici 10-15 weight portion, Herba Ephedrae 10-15 weight portion, Fructus Artocarpi Heterophylli 12-18 weight portion, Testa dolichoris 12-19 weight portion, Fructus Arctii 10-20 weight portion, Cortex Fraxini 19-30 weight portion, Cortex Acanthopanacis Radicis 19-30 weight portion, Herba Medicaginis 15-20 weight portion, Semen setariae 15-25 weight portion, Semen Arecae 10-20 weight portion, Semen Coicis 15-25 weight portion, Poria cum Radix Pini 10-20 weight portion, Semen Phaseoli 13-18 weight portion, Cortex Hibisci 12-19 weight portion, Fructus Piperis 13-15 weight portion, Tremella 10-14 weight portion, Fructus Quisqualis 13-20 weight portion, Moschus 10-20 weight portion, Foliumet Ramulus Evodiae 15-20 weight portion, Pericarpium Citri Reticulatae 20-25 weight portion, Ganoderma 20-25 weight portion, Bulbus Allii 10-13 weight portion, Fructus Jujubae 20-30 weight portion and Fructus Crataegi 15-20 weight portion.
Described medicine is preferably comprised of the crude drug of following ratio of weight and number: Radix Ophiopogonis 20 weight portions, Radix Scutellariae 19 weight portions, BAIMI 25 weight portions, Flos Bombacis Malabarici 13 weight portions, Herba Ephedrae 12 weight portions, Fructus Artocarpi Heterophylli 15 weight portions, Testa dolichoris 16 weight portions, Fructus Arctii 15 weight portions, Cortex Fraxini 25 weight portions, Cortex Acanthopanacis Radicis 24 weight portions, Herba Medicaginis 17 weight portions, Semen setariae 20 weight portions, Semen Arecae 15 weight portions, Semen Coicis 20 weight portions, Poria cum Radix Pini's 15 weight portions, Semen Phaseoli 16 weight portions, Cortex Hibisci 15 weight portions, Fructus Piperis 14 weight portions, Tremella 12 weight portions, Fructus Quisqualis 15 weight portions, Moschus 12 weight portions, Foliumet Ramulus Evodiae 17 weight portions, Pericarpium Citri Reticulatae 23 weight portions, Ganoderma 24 weight portions, Bulbus Allii 12 weight portions, Fructus Jujubae 25 weight portions and Fructus Crataegi 18 weight portions.
In order better to realize foregoing invention object, the present invention also provides a kind of preparation method that is used for the treatment of the medicine of swine paratyphoid, and described preparation method comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials, after mixing, be ground into powder; Powder is added in cold water and soaked 24 hours～36 hours, and with slow fire boiling, decocting time is 2 hours～3 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 3～5 times of the powder quality that obtains of the first step;
Second step, the filtering residue that the first step filter is obtained add in cold water again, with slow fire boiling 2～4 times, decoct 1 hour～2 hours at every turn, filter and merge filtrate, obtain the second filtrate, identical in the quality of the water adding and the first step;
The 3rd step, the first filtrate and the second filtrate are merged, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, guarantee that inlet temperature is at 160 ℃～170 ℃, 50 ℃～70 ℃ of leaving air temps, be ground into subsequently 200 order～400 orders, obtain drug powder.
The beneficial effect that technical scheme provided by the invention is brought is: the present invention is Therapeutic Principle according to " strengthening vital QI to eliminate pathogenic factors, clearing away heat and nourishing YIN, anti-inflammatory and antalgic ", to suffering from the pig treatment of paratyphoid fever, have evident in efficacy, treating both the principal and secondary aspects of a disease, strengthening vital QI to eliminate pathogenic factors, cure rate is high, toxic and side effects is little, is difficult for recurrence, the advantage that cost is low.
The specific embodiment
Chinese veterinarian think swine paratyphoid disease belong to damp and hot due to, damp and hot outer attack or from interior life, damp and hotly fights mutually, delays three warmers, gasification is obstructed, water channel is not smooth, and body internal organs healthy energy can not be fluent, and anti-heresy is unable, causes heating not smooth, tired mind, fever subsiding after perspiration, re-heat then, touching difficulty more, becomes typhoid fever; Damp and hot fumigating in interior, can cause the internal organs congestion enlargements such as spleen, liver, and serous coat is hemorrhage, the inflammation of intestinal ulcer, foul strongly fragrant corruption; Damp and hot removing toxic substances is invaded outward, and the visible multiple speckle of skin surface is hemorrhage or form crust sample eczema.Primary disease should take " strengthening vital QI to eliminate pathogenic factors, clearing away heat and nourishing YIN and anti-inflammatory and antalgic " be Therapeutic Principle, improve the immunity of pig.According to above-mentioned theory and principle, the invention provides a kind of medicine that is used for the treatment of swine paratyphoid, comprise following raw medicinal material: Radix Ophiopogonis, Radix Scutellariae, BAIMI, Flos Bombacis Malabarici, Herba Ephedrae, Fructus Artocarpi Heterophylli, Testa dolichoris, Fructus Arctii, Cortex Fraxini, Cortex Acanthopanacis Radicis, Herba Medicaginis, Semen setariae, Semen Arecae, Semen Coicis, Poria cum Radix Pini, Semen Phaseoli, Cortex Hibisci, Fructus Piperis, Tremella, Fructus Quisqualis, Moschus and Foliumet Ramulus Evodiae.
The pharmacological property of each crude drug is as follows:
Radix Ophiopogonis: sweet; Micro-hardship; Cold.Cure mainly: nourishing YIN and moistening the lung; Reinforcing stomach reg fluid; Relieving restlessness clears away heart-fire.Dryness of the lung dry cough, spits blood, spitting of blood, and consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, quenches one's thirst, calentura Tianjin wound, dry mouth and throat, constipation.< < book on Chinese herbal medicine converges says > >: Radix Ophiopogonis, the medicine of clearing away heart-fire and moistening the lung also.Main deficiency of heart-QI, palpitation with fear palpitation with a distress feeling, forgetful in a trance, spirit fall; Or the lung-heat dryness of the lung, cough sound running fire, consumptive lung disease leaf scorch, the dyspnea due to deficiency of losing heart, in fire volt lung, spitting of blood hemoptysis; Or asthenia exopathogenic heat, body fluid is dry few; Or taste are dry dries up, constipation due to insufficiency dyschezia; All the strongly fragrant card of cardiopulmonary kidney spleen unit asthenic fire is also for this.Yet sweet in the mouth gas is flat, energy lung benefiting gold, bitter in the mouth is cold in nature, can fall heart-fire, and body profit matter is mended, and can support medulla renis, and the merit of specially controlling strain deficiency-heat is in the majority.Stagnation of QI in chest and abdomen as main in front Gu, damaging the spleen and stomach wound is full, and stomach channels is exhausted, and the weakness and emaciation disease such as lose heart, belongs to strain bright.The newly organized > > of < < book on Chinese herbal medicine: Radix Ophiopogonis, the volt fire in eliminating the pathogens from the lung, the pathogenic heat in clearing stomach, the impairment caused by overstrain of reinforcing the heart gas, the vomiting of hemostasis man, beneficial smart reinforcing YIN-essence, separates tired quenching the thirst, U.S. color, happy skin, reducing the asthenic fever, separates the dryness of the lung, fixed cough, what very can hold is monarch and making also for minister of can borrowing.But the magical effect of common people unknown Radix Ophiopogonis, often use less and can not be successfully for unfortunately also.Do not know that Radix Ophiopogonis is necessary multiplex, strength begins large, and Gai Huofu, in lung, sparkles dry interior liquid, and more than Radix Ophiopogonis, fire can not be made; Heat is vehement in stomach, endures its moon to the greatest extent, and more than Radix Ophiopogonis, fire can not cease.The fire that more has bladder, superinverse is in ambition, and urine drop can not go out, and people thinks that urine fire closes, due to the heat of bladder also, with the medicine of water flowing, do not imitate, with the agent of pathogenic fire reducing, do not imitate, how does this use again? the gas of lid bladder, must the clear respectful order of the part of the body cavity above the diaphragm housing the heart and lungs go, and fire is to decline, and water is lower logical.The clear respectful order of husband's part of the body cavity above the diaphragm housing the heart and lungs is reported in lung also, heat of the lung, and making that lung is respectful is clearly not all right, and bladder fire closes, water also closes.Therefore wish is led to bladder person, gas that must lung heat clearing gold, the medicine of lung heat clearing is a lot of, all damages unhelpfully, if do not have benefit in clear Radix Ophiopogonis eventually, can rush down the fire of bladder, and don't damage the gas of bladder, yet use less it, also can not be successful, lid abnormal smells from the patient Radix Ophiopogonis is flat cold, must be multiplex and begin have Ji also.
Radix Scutellariae: have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are used in fungal culture miscellaneous bacteria and infect special severity by the strong feature of broad-spectrum antibacterial action, fine by Radix Scutellariae extracting solution effect.< < Bencao Jingshu > >: Radix Scutellariae, its property is respectful clearly, so evil removing: so bitter in the mouth dampness; So YIN-cold victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, the disease of all damp and hot victory also, is analysed it, all diseases are from recover.Bitter cold can be except damp and hot, thus small intestinal profit and water from by, source is clearly flowed also clean.The blood person of closing, excess-heat is at blood system, and amenorrhea is made us obstructed in instant heating human blood chamber, damp and hot solution, Ying Qi is clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood is stayed knot, and is that carbuncle stain is also rotten: acute scleritis person, fire of moxibustion blood trouble also, removing heat from blood heat extraction, spontaneous recovery also.
BAIMI: acrid in the mouth; Sweet; Bitter; Be slightly cold; Nontoxic.Function cures mainly: main QI invigorating should spleen.
Flos Bombacis Malabarici: sweet; Light; Cool in nature.Return spleen; Liver; Large intestine channel.Function cures mainly: heat clearing away; Dampness removing; Removing toxic substances; Hemostasis.Main having loose bowels; Dysentery; Hemoptysis; Spit blood; Metrorrhagia; Incised wound is hemorrhage; Sore; Eczema.1. the < < SHENGCAO property of medicine is standby wants > >: control dysentery disease, white person is still better.2. < < book on Chinese herbal medicine is asked former > >: red person goes bloody dysentery, and white person controls Hakuri, and Tong Wu Yi nationality tea is decocted normal drink.3. < < gathers medicinal herbs in the south of the Five Ridges and records > >: relieve summer heat.4. the newly organized > > of < < Chinese medicine: diuresis and stomach invigorating.5. < < Nanning City medicine will > >: remuval of damp and hot.Control metrorrhagia, gold wound.6. < < Guangxi Chinese medicinal herbal > >: the poison that dries, control malignant boil.7. the < < of Guangzhou army commonly uses Chinese herbal medicine handbook > >: clearing away heat-damp and promoting diuresis, control enteritis, bacillary dysentery.
Herba Ephedrae: pungent, micro-hardship, temperature.Return lung, urinary bladder channel.Function cures mainly: diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.For anemofrigid cold, uncomfortable in chest breathing with cough, edema due to wind pathogen edema; Bronchial asthma.Honey Herba Ephedrae nourishing the lung to arrest cough.Be used for showing disease and separate, asthma and cough.
Fructus Artocarpi Heterophylli: sweet micro-acid, flat, nontoxic." function cures mainly: 1. < < detailed outline > >: " quench the thirst separate tired, relieving alcoholic intoxication, QI invigorating." 2. < < Guangxi medicine is planted register > >: " promotes the production of body fluid, and quenches the thirst, aid digestion."
Testa dolichoris: sweetness and bitterness; Temperature.Return spleen; Large intestine channel.Function cures mainly: the removing dampness of relieving summer heat, invigorating the spleen and regulating the stomach.In main heat-damp in summer, accumulate, vomiting is had loose bowels, uncomfortable in chest indigestion and loss of appetite, beriberi edema, women's leukorrhagia.1. < < book on Chinese herbal medicine is just read > >: reach the capable water of flesh.2. < < Anhui medical material > >: spleen reinforcing removing dampness, antidiarrheal dysentery.Control alimentary toxicosis vomiting and dirarrhea, separate alcoholism.3. < < plants in Jiangsu medicine will > >: control beriberi foot swollen.
Fructus Arctii: pungent, bitter, cold.Attach to the lung and stomach meridians.Function cures mainly: dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.For anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, mumps erysipelas, carbuncle sore tumefacting virus.
Cortex Fraxini: bitter, puckery, cold.Return liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, astringent therapy, improving eyesight.For hematodiarrhoea, have loose bowels, leucorrhea with red and white discharge, conjunctival congestion and swelling pain, the raw nebula film of order.1. antiinflammatory, analgesic activity.10 mgs/kg of rats by intraperitoneal injection aesculins, diagonal angle justice dish colloidality, dextran, 5-hydroxy tryptamine Xing Ji histamine property " arthritis " have inhibitory action, and the intensity of inhibition is respectively 35,28, and 20,8%.Also have report, aesculin PARA FORMALDEHYDE PRILLS(91,95) " arthritis " also has inhibitory action, but is weaker than diagonal angle justice dish colloidality person, and not obvious to the inhibition of dextran " arthritis ".Aesculetin diagonal angle justice dish colloidality " arthritis " when heavy dose also has inhibitory action.Aesculin can suppress the Granuloma formation (cotton pellet method) of rat, the erythematous response that Cavia porcellus ultraviolet radiation back is caused, also there is inhibitory action, the effect of aesculetin is more remarkable compared with aesculin, both there is the effect of the capillary permeability that remarkable inhibition histamine causes, aesculin also has faint analgesic activity (hot plate method in mice), as using the effect of 5 mgs/kg of morphine subcutaneous injections as 100%, tiring of oral 10 mgs/kg of aesculin is 14.8%.2. the impact on urine amount and urate excretion.Early annual report fraxin has diuresis, can promote the excretion of rabbit and rheumatisant's uric acid.Aesculin is in the test of rat and rabbit, and various route of administration all can be promoted the excretion of uric acid.After rabbit vein injection aesculin, in initial half an hour, urine amount increases, and after this in blood, uric acid concentration is shown in rising, and after half an hour, urine amount reduces gradually, and the excretion of urine uric acid constantly increases.The increase of urine amount, only shows after medicine (may be due to reabsorption reduces) in the short term, and administration is after 3～4 hours, and urine amount is only 1/2 before administration.The action principle of urate excretion enhancement, according to one's analysis, has been sympathetic nervous system excited; And aesculin also has direct effect to kidney, suppressed due to the heavily absorption of uric acid.In blood, uric acid concentration increases the result increasing for uricopoiesis in liver.Also have report, aesculin there is no diuresis to normal rat, and mice is had to more significant diuresis.3. other effect aesculins are generally neither remarkable to the effect of other organs.To the blood pressure of rabbit, breathing, intestinal tube all without effect.To guinea pig in vitro small intestinal, uterus, bladder, gallbladder and isolated frog heart and to rabbit uterus in place, rabbit ear blood vessel, Bufo siccus lower limb vascular also without effect; Also do not affect the blood flow of rabbit carotid artery, femoral artery.Aesculetin has slight boosting to rabbit, can also suppress Isolated Toad Heart and isolated rabbit intestinal, slightly shrinks Bufo siccus lower limb vascular, and the irritability of isolated toad gastrocnemius also slightly reduces.Cortex Fraxini decoct also has some antibacterial, to treat chronic tracheitis effect.The chemical constitution of aesculin is similar to dicoumarol, therefore there is some anticoagulant effect, its 4% solution can absorb ultraviolet, therefore can protect skin, avoids the damage of sun exposure.4. drain, absorption and general toxicity horse chestnut bark glycoside absorb at upper part of small intestine after oral, stomach and large intestine do not absorb; After injection, can come across in gallbladder and urine, in adrenal gland, testis and kidney, occur very early, also can be to brain.The no matter oral or intravenous injection of rat, all has discharge in urine and in stool, take original shape as main, and Cavia porcellus is mainly destroyed in vivo.1 g/kg of lumbar injection of 3 gs/kg of aesculins or aesculetin is in mice, neither lethal, therefore toxicity is very low; But also there are 250 mgs/kg of report aesculetin subcutaneous injections pernicious.Japan's Cortex Fraxini extract, to 3 gs/kg of rabbit gavage every days, only causes slight lesion tissue for continuous 45 weeks, as gastrointestinal mucosa presents the degeneration of expanding of hypersecretion, enteric plexus and glomerule, renal tubules; Long-term drug administration by injection, liver function and tip hemogram are all without significant change.
Cortex Acanthopanacis Radicis: sweet, sour, temperature.Function cures mainly: strengthening the spleen and stomach, and aid digestion, calm the nerves, induce sweat, stimulating milk secretion.For weakness of the spleen and stomach, dyspepsia, neurasthenia, flu, agalactia.
Herba Medicaginis: bitter, micro-puckery, flat.Function cures mainly: stomach invigorating, clearing away heat and promoting diuresis.Cure mainly enteritis, lithangiuria, nyctalopia.
Semen setariae: sweet salty, cool.Specially enter kidney, doublely enter spleen, stomach.Function cures mainly: and in, kidney tonifying, heat extraction, removing toxic substances.Control taste deficiency-heat, regurgitation vomiting, quenches one's thirst, and has loose bowels.Old Semen setariae: dysentery relieving, separate unhappy.
Semen Arecae: bitter in the mouth; Pungent; Warm in nature.Return stomach; Large intestine channel.Effect, anthelmintic; Removing food stagnancy; The therapeutic method to keep the adverse QI flowing downwards; Row water; Preventing the attack (or recurrence) of malaria.Malnutrition due to parasitic infestation; Dyspepsia; Abdominal distention; Heavy after dysentery; Foot gas; Edema; Malaria.Resisting pathogenic microbes effect Semen Arecae infusion (1:1) in vitro to trichophyton, permitted the dermatophytess such as blue achorion and had inhibitory action in various degree.Decoct and some strain of water logging agent infected by influenza A type have certain inhibitory action, and antiviral effect may be relevant with wherein contained tannin.
Semen Coicis: sweet, light, cool.Return spleen, stomach, lung meridian.Function cures mainly: spleen invigorating eliminating dampness by diuresis, and eliminating impediment antidiarrheal, row is dense in heat clearing away.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.
Poria cum Radix Pini: sweet light, flat.Enter the heart, spleen channel.Function cures mainly: mind calming, calm the nerves, and diuretic.Control the palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria.
Semen Phaseoli: sweet, sour, flat.GUIXIN, small intestine meridian.Function cures mainly: inducing diuresis to remove edema, removing toxic substances and promoting pus discharge.For edema distension, beriberi limb is swollen, jaundice dark coloured urine, rheumatism pyretic arthralgia, carbuncle sore tumefacting virus, abdominalgia with intestinal abscess.
Cortex Hibisci: sweet, tepor.Function cures mainly: clearing away heat-damp and promoting diuresis, killing parasites for relieving itching.For dysentery, leucorrhea; Eczema scrotum tinea corporis, tinea pedis are controlled in external.
Fructus Piperis: pungent, heat.Return stomach, large intestine channel.Function cures mainly: warming spleen and stomach for dispelling cold, the therapeutic method to keep the adverse QI flowing downwards, expectorant.For gastrofrigid vomiting, stomachache is had loose bowels, inappetence, epilepsy abundant expectoration.
Tremella: sweet, flat.Function cures mainly: invigorating the lung and benefiting vital QI, nourishing YIN to relieve dryness.For body is empty after being ill, chronic cough of deficiency lung, sputum mixed with blood, metrorrhagia, constipation, hypertension, sclerosis of blood vessels.
Fructus Quisqualis: sweet, temperature.Return spleen, stomach warp.Function cures mainly: killing insect and eliminating accumulation.For ascarid, enterobiasis, abdominal pain due to worm stagnation, infantile malnutrition.
Moschus: pungent, temperature.GUIXIN, spleen channel.Function cures mainly: the refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.For calentura coma, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors stupor, amenorrhea ， WEIJIA, difficult labour stillborn fetus, trusted subordinate's sudden pain, carbuncle scrofula, laryngopharynx swelling and pain, falls and flutters the pain of injury, and arthralgia pain is numb.
Foliumet Ramulus Evodiae: hardship, cold.Function cures mainly: heat-clearing and toxic substances removing, eliminating stasis to stop pain.Prevent and treat influenza, epidemic cerebrospinal meningitis, encephalitis B, heatstroke, the high heat that cures cold, tonsillitis, pharyngolaryngitis, lung abscess, pneumonia, malaria, rheumatic arthritis, sciatica, lumbago and skelalgia, stomachache, icterohepatitis, Gelsemium elegans Benth. (Herba Gelsemii Elegantis) is poisoning.Osteopatia sprain is controlled in external, worm venom, carbuncle furuncle and phyma poison, trauma infection contamination, eczema, dermatitis.
Preferably, the present invention can also comprise: Pericarpium Citri Reticulatae, Ganoderma, Bulbus Allii, Fructus Jujubae and Fructus Crataegi.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship; Return spleen, lung meridian, for diseases such as distension and fullness of the chest and abdomen.The pungent loose logical temperature of Pericarpium Citri tangerinae, fragrant odour, is longer than and regulates the flow of vital energy, can enter spleen lung, thus can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, for lung qi, gather around the diseases such as stagnant, chest and diaphragm feeling of fullness and stagnation of QI in spleen and stomach, distension and fullness in the abdomen, for retention of dampness in middle-JIAO, gastral cavity abdomen painful abdominal mass is swollen, have loose bowels in loose stool, and the disease such as abundant expectoration cough.Pericarpium Citri tangerinae dispelling the damp pathogen with bitter and warm drugs and can spleen invigorating circulation of qi promoting, therefore be usually used in the diseases such as retention of dampness in middle-JIAO, gastral cavity abdominal distention are vexed, loose stool greasy fur, can compatibility Rhizoma Atractylodis, Cortex Magnoliae Officinalis is with using.Be good at again drying dampness to eliminate phlegm, for controlling damp-phlegm, stop up the conventional key medicine of lung, abundant expectoration cough, for insufficiency of the spleen diet reduce, dyspepsia, and the disease such as nausea and vomiting.This product dampness and can spleen benefiting and stimulating the appetite, is applicable to the diseases such as weakness of the spleen and stomach, diet minimizing, dyspepsia, loose stool and diarrhea, the fit applications such as normal and Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria.Can spleen invigorating because of it, can regulate the flow of vital energy again, therefore often make as the assistant of Qi-tonifying drug, can make tonify without causing stagnation, prevent from stopping up and hold back the swollen effect of doing, in addition, Pericarpium Citri tangerinae again can with in, can control stomach-QI being unable to descend normally, nausea and vomiting.
Ganoderma: property is sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, and respiratory system is had to phlegm-dispelling functions, in addition, also has hepatoprotective, improves immunologic function, antibacterially waits effect.
Bulbus Allii: warm in nature, acrid in the mouth is put down; Enter spleen, stomach, lung meridian.Removing toxic substances parasite killing, reducing swelling and alleviating pain, antidiarrheal dysentery relieving, controls lung, and anthelmintic also has warming the spleen warming the stomach in addition.Control swollen ulcer drug, white bald tinea skin ulcer, dysentery is had loose bowels, pulmonary tuberculosis pertussis, ascarid pinworm, eating accumulation, coldness and pain in the epigastrium, edema distension, circulation of qi promoting removing food stagnancy, parasite killing removing toxic substances.For flu, bacillary dysentery, amebic dysentery, enteritis, eating accumulation, carbuncle skin infection.Strong disinfecting: in Bulbus Allii, sulfur-containing compound has strong antibacterial and anti-inflammation functions, all has and suppresses and killing action multiple coccus, bacillus, fungus and virus etc., is the strongest a kind of of antibacterial action in the natural plants of finding at present.Anti-curing oncoma and cancer: the elements such as the germanium in Bulbus Allii and selenium can inhibition tumor cell and the growth of cancerous cell, experiment finds, the crowd that cancer incidence is minimum is exactly the highest crowd of selenium content in blood.American National cancerous tissue thinks, in the plant of the anticancer potentiality of tool in the whole world, what rank first is Bulbus Allii.Toxin-expelling intestine-cleaning, prevention of gastrointestinal: Bulbus Allii can effectively suppress and kill the bacterial viruses such as helicobacter pylori that cause gastroenteropathy, removes the intestines and stomach noxious substance, and stimulating gastrointestinal mucosa promotes appetite, accelerates digestion.Reduce blood glucose, prevent diabetes: Bulbus Allii can promote the secretion of insulin, increases the absorption of histiocyte to glucose, improve human glucose tolerance, reduce rapidly blood sugar level in body, and can kill the various pathogenic bacterias because of infection-induced diabetes, thereby effectively prevent and treat diabetes.Control cardiovascular and cerebrovascular disease: Bulbus Allii can prevent the lipidosis in cardiovascular and cerebrovascular vessel, the metabolism of induced tissue fat inside, significantly increase fibrinolytic activity, reduce cholesterol, suppress hematoblastic gathering, reduce plasma concentration, increase arteriolar expansion ratio, impel vasodilation, regulate blood pressure, increase the permeability of blood vessel, thereby suppress formation and the prevention of arterial sclerosis of thrombosis.Eating 2 ~ 3 lobe Bulbus Alliis every day, is the preferably the most easy way of blood pressure lowering, and Bulbus Allii can help the right quantity of a kind of enzyme in holder and avoid occurring hypertension.
Fructus Jujubae: there is immunosuppressive action, the ethanol extract of Fructus Jujubae with every day 100mg to rat oral gavage, show that Fructus Jujubae and azathioprine have same immunosuppressant; To atopic diseases, can suppress the generation of antibody.Fructus Jujubae ethanol extract may have inhibitory action to rat reactive antibody, and non-reacted antibody is not produced to other effects of inhibitory action: the two glucoside A of flavone in Fructus Jujubae, pharmacological evaluation proof has calmness, hypnosis and hypotensive effect, Fructus Jujubae to have the effect that increases cAMP in leukocyte.Fructus Jujubae decoct can reduce the damage of CCl4 to Rabbit Liver.Can extend the swimming time of mice.Report Fructus Jujubae has the proliferation function of anticancer recently.
Fructus Crataegi: section is dried, putting uses force in pot fries to outer wrinkly face brown, inner yellowish-brown as degree greatly, spray clear water, and taking-up is dried, and is Fructus Crataegi (parched to brown).There is appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, the effect of promoting blood circulation to remove blood stasis, the circulation of qi promoting of reducing phlegm, meridian distribution of property and flavor, sour, sweet, slightly warm in nature.Main component is containing chlorogenic acid, caffeic acid, Crataegolic acid, neat chrysanthemum fruit acid, Quercetin, ursolic acid, oleanolic acid, hyperin, epicatechin etc.Oral Fructus Crataegi can increase digestive enzyme, promotes fatty decomposition and digestion, to because of eat meat or greasy too much due to distension and fullness in the abdomen, belch, anorexia, stomachache, diarrhoea person, curative effect is especially good.In addition, modern medicines tests shows, Fructus Crataegi has the slow and lasting effect reducing blood pressure, and also can reduce cholesterol and triglyceride, atherosclerosis, but also can diastole coronary artery, increase myocardial contraction, to arrhythmia.Therefore, be conducive to prevent and treat hypertension, hyperlipidemia, arteriosclerosis and coronary heart disease.
Embodiment 1 medicine 1
The embodiment of the present invention 1 provides a kind of medicine that is used for the treatment of swine paratyphoid, by following crude drug, formed: Radix Ophiopogonis 21 weight portions, Radix Scutellariae 15 weight portions, BAIMI 21 weight portions, Flos Bombacis Malabarici 15 weight portions, Herba Ephedrae 13 weight portions, Fructus Artocarpi Heterophylli 15 weight portions, Testa dolichoris 15 weight portions, Fructus Arctii 15 weight portions, Cortex Fraxini 23 weight portions, Cortex Acanthopanacis Radicis 22 weight portions, Herba Medicaginis 20 weight portions, Semen setariae 20 weight portions, Semen Arecae 15 weight portions, Semen Coicis 20 weight portions, Poria cum Radix Pini's 15 weight portions, Semen Phaseoli 15 weight portions, Cortex Hibisci 15 weight portions, Fructus Piperis 13 weight portions, Tremella 15 weight portions, Fructus Quisqualis 13 weight portions, Moschus 17 weight portions and Foliumet Ramulus Evodiae 21 weight portions.
The preparation method of medicine comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials, after mixing, be ground into powder; Powder is added in cold water and soaked 24 hours, and with slow fire boiling, decocting time is 2 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 3 times of the powder quality that obtains of the first step;
Second step, the filtering residue that the first step filter is obtained add in cold water again, with slow fire boiling 2 times, decoct 1 hour at every turn, filter and merge filtrate, obtain the second filtrate, identical in the quality of the water adding and the first step;
The 3rd step, the first filtrate and the second filtrate are merged, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, guarantees that inlet temperature is at 170 ℃, and 60 ℃ of leaving air temps, are ground into 200 orders subsequently, obtain drug powder.
Embodiment 2 medicines 2
The embodiment of the present invention 2 provides a kind of medicine that is used for the treatment of swine paratyphoid, by following crude drug, formed: Radix Ophiopogonis 20 weight portions, Radix Scutellariae 19 weight portions, BAIMI 25 weight portions, Flos Bombacis Malabarici 13 weight portions, Herba Ephedrae 12 weight portions, Fructus Artocarpi Heterophylli 15 weight portions, Testa dolichoris 16 weight portions, Fructus Arctii 15 weight portions, Cortex Fraxini 25 weight portions, Cortex Acanthopanacis Radicis 24 weight portions, Herba Medicaginis 17 weight portions, Semen setariae 20 weight portions, Semen Arecae 15 weight portions, Semen Coicis 20 weight portions, Poria cum Radix Pini's 15 weight portions, Semen Phaseoli 16 weight portions, Cortex Hibisci 15 weight portions, Fructus Piperis 14 weight portions, Tremella 12 weight portions, Fructus Quisqualis 15 weight portions, Moschus 12 weight portions, Foliumet Ramulus Evodiae 17 weight portions, Pericarpium Citri Reticulatae 23 weight portions, Ganoderma 24 weight portions, Bulbus Allii 12 weight portions, Fructus Jujubae 25 weight portions and Fructus Crataegi 18 weight portions.
The preparation method of medicine comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials, after mixing, be ground into powder; Powder is added in cold water and soaked 36 hours, and with slow fire boiling, decocting time is 3 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 5 times of the powder quality that obtains of the first step;
Second step, the filtering residue that the first step filter is obtained add in cold water again, with slow fire boiling 3 times, decoct 1.5 hours at every turn, filter and merge filtrate, obtain the second filtrate, identical in the quality of the water adding and the first step;
The 3rd step, the first filtrate and the second filtrate are merged, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, guarantees that inlet temperature is at 160 ℃ ℃, and 70 ℃ of leaving air temps, are ground into 300 orders subsequently, obtain drug powder.
Toxicity test
1, cumulative toxicity test report
Select 20 healthy mices, female, male each 10, the medicine of the embodiment of the present invention 1 of take is object, it is first phase that dosage designs every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, and the LD 50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjust dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose, to tested material after 20 days, female, buck all occurs without death condition.The medicine 2 of embodiment 2 of take is object, carries out according to the method described above toxicity test, and result is as identical in embodiment 1.
2, acute toxicity test
40 of application NIH mices, SPF level, male and female half and half, body weight 16～20g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, matched group and administration group, test front fasting 12 hours; Medicine dissolution prepared by embodiments of the invention 1 is in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 32.9 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and records toxic reaction and the death toll of mice.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.The medicine LD50>32.9 crude drug/kg of the mice oral administration gavage embodiment of the present invention 1, every day, maximum dosage-feeding was 65.8g crude drug/kg/ day.The clinical application amount of the embodiment of the present invention 1 medicine 1 is 3g crude drug/day/head, and piglet body weight is in 6kg, and average dosage is 0.5g crude drug/kg/ day.By weighing machine: the dosis tolerata of the medicine of mice (average weight take 20g) the oral administration gavage embodiment of the present invention 1 is quantity 131 times.Therefore the acute toxicity of the medicine 1 of the embodiment of the present invention 1 is low, clinical drug safety.The medicine 2 of embodiment 2 of take is object, carries out according to the method described above toxicity test, and result is as identical in embodiment 1.
Clinical trial
(1) laboratory animal
Pig farm, Accessories during Binzhou, Shandong Province finds that in August, 2012 phenomenon of pig death appears in piglet group, swinery is carried out to clinical examination, find that in swinery, most piglets occur that fever is to more than 41 ℃, the phenomenon that has diarrhoea, excretion canescence or yellow stench feces, dyspnea, under the basal part of the ear and abdomen, skin has purpura; Dead piglet is dissected, found that congestion appears in the skins such as ear, abdominal part, on intestinal mucosa, have the rotten milk of one deck lark, liver, renomegaly, hemorrhage.Through clinical examination, there are 290 piglets nearly to suffer from gastric ulcer, select wherein 150 body weight in the ill piglet of 8kg left and right experiment pig the most.
(2) test method
By 150 ill piglets, with entering to be divided into three experimental grouies, 50 every group, every group of average weight is 8kg.Three groups of medicine 1(embodiment groups 1 of using respectively the embodiment of the present invention 1), the medicine 2(embodiment group 2 of embodiment 2) and conventional medicament (matched group) treat.Embodiment 1 and 2 adds feedstuff by medicine 1 and medicine 2 according to the percentage by weight of feedstuff 5-12% respectively; Conventional medicament is selected oxytetracycline, every day every kg body weight 50-100 milligram, minute 2-3 time is oral.Test period is 3-7 days.
(3) criterion of therapeutical effect
Recovery from illness: symptom, sign, microbiology and four of laboratory examinations all recover normal;
Effective: symptom, sign, microbiology and laboratory examination wherein one do not recover normal;
Effective: after medication, the state of an illness takes a turn for the better to some extent, but obvious not; Symptom, sign, microbiology and laboratory examination wherein at least two do not recover normal;
Invalid: after medication, the state of an illness even increases the weight of without taking a turn for the better.
Wherein, recovery from illness and effective number are counted effective percentage.
(4) therapeutic outcome
The results are shown in Table 1, from therapeutic effect, adopting medicine of the present invention is more than 88% to the treated effect of swine paratyphoid, higher than matched group.
From the data of table 1, can find out: compare with matched group, use the Drug therapy pig swine paratyphoid of the embodiment of the present invention 1 and embodiment 2, have advantages of evident in efficacy, cure rate is high; In long-term observation subsequently, find, the piglet that embodiment group 1 and embodiment group 2 cured again sickness rate is starkly lower than the pig of matched group.
Concrete case
Case 1
Wu in May, 2011 find 17 ablactational baby pig all appearance in various degree fever to more than 41 ℃, diarrhoea, excretion canescence or yellow stench feces, dyspnea, under the basal part of the ear and abdomen, skin has the symptoms such as purpura, through tentative diagnosis, is swine paratyphoid.To the medicine that adds the embodiment of the present invention 1 of feedstuff gross weight 8% in feedstuff, to adhere to using 5 days, 17 piglets all recover normal.
Case 2
In August, 2012, Distributions in Liaocheng of Shandong Province pig farm, finds that 1 piglet is dead, the piglet of 35 all appearance fever in various degree to more than 41 ℃, diarrhoea, excretion canescence or yellow stench feces, dyspnea, under the basal part of the ear and abdomen, skin has the symptoms such as purpura, dead piglet is dissected, find that congestion appears in the skins such as abdominal part, on intestinal mucosa, have the rotten milk of one deck lark, liver, renomegaly, hemorrhage.Be diagnosed as swine paratyphoid.35 ill piglets isolation are fed separately, to the medicine that adds the embodiment of the present invention 2 of feedstuff gross weight 12% in feedstuff, adhere to using 3 days, 30 piglets all recover normally, continue use three days, and it is normal that other piglets all recover.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (8)
1. the medicine that is used for the treatment of swine paratyphoid, it is characterized in that, described medicine comprises following crude drug: Radix Ophiopogonis, Radix Scutellariae, BAIMI, Flos Bombacis Malabarici, Herba Ephedrae, Fructus Artocarpi Heterophylli, Testa dolichoris, Fructus Arctii, Cortex Fraxini, Cortex Acanthopanacis Radicis, Herba Medicaginis, Semen setariae, Semen Arecae, Semen Coicis, Poria cum Radix Pini, Semen Phaseoli, Cortex Hibisci, Fructus Piperis, Tremella, Fructus Quisqualis, Moschus and Foliumet Ramulus Evodiae.
2. the medicine that is used for the treatment of swine paratyphoid according to claim 1, it is characterized in that, described medicine is comprised of the crude drug of following ratio of weight and number: Radix Ophiopogonis 10-30 weight portion, Radix Scutellariae 10-20 weight portion, BAIMI 15-30 weight portion, Flos Bombacis Malabarici 10-20 weight portion, Herba Ephedrae 10-15 weight portion, Fructus Artocarpi Heterophylli 10-20 weight portion, Testa dolichoris 10-20 weight portion, Fructus Arctii 10-20 weight portion, Cortex Fraxini 15-30 weight portion, Cortex Acanthopanacis Radicis 15-30 weight portion, Herba Medicaginis 15-25 weight portion, Semen setariae 10-30 weight portion, Semen Arecae 10-20 weight portion, Semen Coicis 10-30 weight portion, Poria cum Radix Pini 10-20 weight portion, Semen Phaseoli 10-20 weight portion, Cortex Hibisci 10-20 weight portion, Fructus Piperis 10-20 weight portion, Tremella 10-20 weight portion, Fructus Quisqualis 10-20 weight portion, Moschus 10-25 weight portion and Foliumet Ramulus Evodiae 15-25 weight portion.
3. the medicine that is used for the treatment of swine paratyphoid according to claim 1 and 2, it is characterized in that, described medicine is comprised of the crude drug of following ratio of weight and number: Radix Ophiopogonis 21 weight portions, Radix Scutellariae 15 weight portions, BAIMI 21 weight portions, Flos Bombacis Malabarici 15 weight portions, Herba Ephedrae 13 weight portions, Fructus Artocarpi Heterophylli 15 weight portions, Testa dolichoris 15 weight portions, Fructus Arctii 15 weight portions, Cortex Fraxini 23 weight portions, Cortex Acanthopanacis Radicis 22 weight portions, Herba Medicaginis 20 weight portions, Semen setariae 20 weight portions, Semen Arecae 15 weight portions, Semen Coicis 20 weight portions, Poria cum Radix Pini's 15 weight portions, Semen Phaseoli 15 weight portions, Cortex Hibisci 15 weight portions, Fructus Piperis 13 weight portions, Tremella 15 weight portions, Fructus Quisqualis 13 weight portions, Moschus 17 weight portions and Foliumet Ramulus Evodiae 21 weight portions.
4. according to the medicine that is used for the treatment of swine paratyphoid described in claim 1-3 any one, it is characterized in that, described medicine also comprises: Pericarpium Citri Reticulatae, Ganoderma, Bulbus Allii, Fructus Jujubae and Fructus Crataegi.
5. according to the medicine that is used for the treatment of swine paratyphoid described in claim 1-4 any one, it is characterized in that, described medicine is comprised of the crude drug of following ratio of weight and number: Radix Ophiopogonis 10-30 weight portion, Radix Scutellariae 10-20 weight portion, BAIMI 15-30 weight portion, Flos Bombacis Malabarici 10-20 weight portion, Herba Ephedrae 10-15 weight portion, Fructus Artocarpi Heterophylli 10-20 weight portion, Testa dolichoris 10-20 weight portion, Fructus Arctii 10-20 weight portion, Cortex Fraxini 15-30 weight portion, Cortex Acanthopanacis Radicis 15-30 weight portion, Herba Medicaginis 15-25 weight portion, Semen setariae 10-30 weight portion, Semen Arecae 10-20 weight portion, Semen Coicis 10-30 weight portion, Poria cum Radix Pini 10-20 weight portion, Semen Phaseoli 10-20 weight portion, Cortex Hibisci 10-20 weight portion, Fructus Piperis 10-20 weight portion, Tremella 10-20 weight portion, Fructus Quisqualis 10-20 weight portion, Moschus 10-25 weight portion, Foliumet Ramulus Evodiae 15-25 weight portion, Pericarpium Citri Reticulatae 15-30 weight portion, Ganoderma 15-25 weight portion, Bulbus Allii 10-15 weight portion, Fructus Jujubae 15-35 weight portion and Fructus Crataegi 15-25 weight portion.
6. according to the medicine that is used for the treatment of swine paratyphoid described in claim 1-5 any one, it is characterized in that, described medicine is comprised of the crude drug of following ratio of weight and number: Radix Ophiopogonis 15-25 weight portion, Radix Scutellariae 15-20 weight portion, BAIMI 20-30 weight portion, Flos Bombacis Malabarici 10-15 weight portion, Herba Ephedrae 10-15 weight portion, Fructus Artocarpi Heterophylli 12-18 weight portion, Testa dolichoris 12-19 weight portion, Fructus Arctii 10-20 weight portion, Cortex Fraxini 19-30 weight portion, Cortex Acanthopanacis Radicis 19-30 weight portion, Herba Medicaginis 15-20 weight portion, Semen setariae 15-25 weight portion, Semen Arecae 10-20 weight portion, Semen Coicis 15-25 weight portion, Poria cum Radix Pini 10-20 weight portion, Semen Phaseoli 13-18 weight portion, Cortex Hibisci 12-19 weight portion, Fructus Piperis 13-15 weight portion, Tremella 10-14 weight portion, Fructus Quisqualis 13-20 weight portion, Moschus 10-20 weight portion, Foliumet Ramulus Evodiae 15-20 weight portion, Pericarpium Citri Reticulatae 20-25 weight portion, Ganoderma 20-25 weight portion, Bulbus Allii 10-13 weight portion, Fructus Jujubae 20-30 weight portion and Fructus Crataegi 15-20 weight portion.
7. according to the medicine that is used for the treatment of swine paratyphoid described in claim 1-6 any one, it is characterized in that, described medicine is comprised of the crude drug of following ratio of weight and number: Radix Ophiopogonis 20 weight portions, Radix Scutellariae 19 weight portions, BAIMI 25 weight portions, Flos Bombacis Malabarici 13 weight portions, Herba Ephedrae 12 weight portions, Fructus Artocarpi Heterophylli 15 weight portions, Testa dolichoris 16 weight portions, Fructus Arctii 15 weight portions, Cortex Fraxini 25 weight portions, Cortex Acanthopanacis Radicis 24 weight portions, Herba Medicaginis 17 weight portions, Semen setariae 20 weight portions, Semen Arecae 15 weight portions, Semen Coicis 20 weight portions, Poria cum Radix Pini's 15 weight portions, Semen Phaseoli 16 weight portions, Cortex Hibisci 15 weight portions, Fructus Piperis 14 weight portions, Tremella 12 weight portions, Fructus Quisqualis 15 weight portions, Moschus 12 weight portions, Foliumet Ramulus Evodiae 17 weight portions, Pericarpium Citri Reticulatae 23 weight portions, Ganoderma 24 weight portions, Bulbus Allii 12 weight portions, Fructus Jujubae 25 weight portions and Fructus Crataegi 18 weight portions.
8. a preparation method for the medicine that is used for the treatment of swine paratyphoid as described in claim 1-7 any one, is characterized in that, described preparation method comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials, after mixing, be ground into powder; Powder is added in cold water and soaked 24 hours～36 hours, and with slow fire boiling, decocting time is 2 hours～3 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 3～5 times of the powder quality that obtains of the first step;
Second step, the filtering residue that the first step filter is obtained add in cold water again, with slow fire boiling 2～4 times, decoct 1 hour～2 hours at every turn, filter and merge filtrate, obtain the second filtrate, identical in the quality of the water adding and the first step;
The 3rd step, the first filtrate and the second filtrate are merged, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, guarantee that inlet temperature is at 160 ℃～170 ℃, 50 ℃～70 ℃ of leaving air temps, be ground into subsequently 200 order～400 orders, obtain drug powder.
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| CN102038099A (en) * | 2010-09-14 | 2011-05-04 | 周剑峰 | Feed additive for preventing and treating pig paratyphus |
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| 于华光: "中药治疗仔猪副伤寒", 《中兽医学杂志》 * |
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|---|---|---|---|---|
| CN105343602A (en) * | 2015-11-20 | 2016-02-24 | 陈启福 | Chinese patent medicine composition used for treating chicken paratyphoid, and preparation method thereof |
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| CN103656355B (en) | 2016-01-06 |
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Effective date of registration: 20191106 Address after: 550018 No. 998, Jinhua Town, guanshanhu District, Guiyang City, Guizhou Province Patentee after: Guiyang new hope agricultural science and Technology Co., Ltd. Address before: 266061 Shandong city of Qingdao province Chengyang Jihongtan Street Green Industrial Park Patentee before: Shandong New Hope Liuhe Group Co., Ltd. |