CN1861166A - Medicinal composition for treating hyperinsulinar type polycystic overies and its prepn. method - Google Patents

Abstract

A Chinese medicine in the form of capsule, tablet or particle for treating high-insulin polycystic ovary syndrome, high-androgen amenorrhoea, etc is prepared from 14 Chinese-medicinal materials including anemarrhena rhizome, epimedium, wolfberry fruit, fleece flower root etc. Its preparing process is also disclosed.

Description

A kind of pharmaceutical composition for the treatment of high insulin polycystic ovary syndrome and preparation method thereof

Technical field

The invention belongs to field of traditional Chinese medicine pharmacy, particularly be used for the treatment of the Chinese medicine composition of women's high insulin polycystic ovary syndrome, relate to the preparation method of said composition simultaneously.

Background technology

Polycystic ovarian syndrome (POOS) is the common endocrine regulation diseases of the women of child-bearing age, because its cause of disease complexity, shows variously, and high insulin polycystic ovary syndrome is arranged; The amenorrhea of excessive androgen type anovulation, companion's hyperinsulinemia, it is that main Cervical back, oxter and pudendum part skin slightly can have melanin pigmentation (black sour jujube skin phenomenon) that hypertension, diabetes family members' history, obesity, outstanding above abdominal obesity are often arranged, hirsutism, normal performance have symptoms such as xerostomia, vexed or constipation, tongue be dark red.At present clinical therapeutic effect is still unsatisfactory.Therefore, this disease becomes the focus and the difficult point of gynaecopathia research day by day.

Summary of the invention

The purpose of this invention is to provide a kind of pharmaceutical composition for the treatment of high insulin polycystic ovary syndrome.Further purpose of the present invention provides this preparation of drug combination method.

Pharmaceutical composition of the present invention is mainly used in the treatment high insulin polycystic ovary syndrome; The amenorrhea of excessive androgen type anovulation, companion's hyperinsulinemia, it is that main Cervical back, oxter and pudendum part skin slightly have melanin pigmentation that hypertension, diabetes family members' history, obesity, outstanding above abdominal obesity are arranged, hirsutism, yin deficiency and blood stasis phlegm-damp card persons such as xerostomia, vexed or constipation, tongue are dark red are to clomiphene treatment nonresponder.

Chinese medicine does not still have the record of this name of disease, according to clinical manifestations such as its menoxenia, infertile, amenorrheas, should belong to categories such as " amenorrhea ", " infertile ", " menoxenia ".Modern Chinese medicine is thought and is suffered from a deficiency of the kidney and two important pathogenesis of the tired POOS of being of blood.Thinking that again primary disease is tired for the blood of suffering from a deficiency of the kidney, based on insufficiency of kidney-YANG, usually is the deficiency of YIN and sun.Re-recognize for to suffer from a deficiency of the kidney.

Pharmaceutical composition of the present invention is with the kidney tonifying heat clearing away, and phlegm reduction of blood circulation promoting is with sufficient kidney yin, Yin Yang balancing, change fertile people's constitution of YIN-deficiency, dispel the consume of interior-heat essence and blood, the blood flow smoothness, kidney qi foot, phlegm-damp must be changed simultaneously, dash and appoint self-regulated, adopt the Chinese medicine Hippocampus, the Rhizoma Anemarrhenae, Radix Ophiopogonis, Rhizoma Polygonati, Fructus Lycii, Rhizoma Coptidis, Carapax et Plastrum Testudinis, the Radix Polygoni Multiflori, Radix Et Rhizoma Rhei, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Acori Graminei and Herba Verbenae are made.Wherein Rhizoma Anemarrhenae bitter cold is gone into lung, kidney, stomach warp, nourishing kidney and clearing heat, and relieving restlessness is allayed excitement; Close the Herba Epimedii that the little hot temperature of sweet perfume (or spice) is gone into liver, kidney channel, the kidney invigorating and essence nourishing is transferred to dash and is appointed, and two medicines are principal agent of the present invention.Get the salty-cold in love product Carapax et Plastrum Testudinis of flesh and blood of going into liver, kidney channel, the marrow mind calming is mended in the YIN nourishing replenishing essence; Sweet little bitter cold is gone into the Radix Ophiopogonis of the heart, lung, stomach warp, Yin-nourishing and body fluid promoting, tired the quenching one's thirst of dispelling; Sweet Fructus Lycii of putting down into spleen, liver, kidney, lung meridian, liver and kidney tonifying, Yi Yan calms the nerves; Sweet Rhizoma Polygonati of putting down into lung, spleen, stomach warp, the spleen reinforcing lung moistening is promoted the production of body fluid and is preserved youthful looks; Gan Wen is the in love product Hippocampus of flesh and blood of impairment of YIN not, the kidney warming tonify deficiency; Close the Radix Polygoni Multiflori that bitter sweet tepor is gone into liver, kidney channel again, invigorating the liver and kidney, benefiting essence-blood is adjuvant altogether.The Rhizoma Coptidis bitter cold is gone into the heart, lung, gallbladder, stomach, the large intestine Five Classics, clears away heart-fire, the fire of lung, large intestine; The Radix Et Rhizoma Rhei processed with wine is gone into spleen, liver, large intestine channel to subtract its bitter cold, the purging FU-organs of invigorating blood circulation; The hot temperature of Spina Gleditsiae is gone into lung, large intestine channel, and the hot temperature of loosing is logical, activating blood circulation and dissipating phlegm, and the sharp power profit of property, the arduous temperature of Rhizoma Acori Graminei is gone into the heart, Liver Channel, reduces phlegm to remove and stops up, and it is sensible to refresh oneself; Close the Herba Verbenae hardship and be slightly cold into liver, spleen channel, the promoting the circulation of blood diuretic is controlled the wet resistance of married woman's stasis, the enlarged abdomen amenorrhea; Four flavors are adjuvant drug, the deficiency of the removing heat-phlegm of invigorating blood circulation that still has in the auxiliary main and auxiliary medicine enriching kidney essence.Select sweet arduous using warming therapy Radix Angelicae Sinensis, go into the heart, spleen channel promoting the circulation of bloodization and stagnate, moisturize the taste lung, be guiding drug of the present invention.。

Above-mentioned each medical material is wherein:

The Rhizoma Anemarrhenae: be the dry rhizome of liliaceous plant Rhizoma Anemarrhenae Anemarrhena asphodeloides Bge..Spring, Qiu Erji excavate, and remove fibrous root and silt, dry.Nature and flavor hardship, sweet, cold.Return lung, stomach, kidney channel.Have clearing away heat-fire, promote the production of body fluid and moisturize.Be used for fever caused by exogenous pathogenic factors, the hyperpyrexia excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, the dryness of the intestine constipation.

Studies show that, the general unit of effective ingredient Rhizoma Anemarrhenae soap (zMS) in the Rhizoma Anemarrhenae has can improve the memory of plan Model of Dementia animal learning, rising superoxide dismutase (soD) vigor, reduce lipid peroxide (LPO) and the lipofuscin (concentration of L agate, strengthen choline second phthalein transferring enzyme (chAT) activity in the brain, and can reduce intracerebral injection A β 25-35 rat model cerebral tissue Zou effectively and deposit pharmacological actions such as speckle.

Herba Epimedii: be the dry aerial parts of Berberidaceae plant Herba Epimedii Epimedium brevicornum Maxim., arrow leaf Herba Epimedii Epimediumsagittatum (Sieb.et Zucc.) Maxim., pubescence Herba Epimedii Epimediumpubescens Maxim., Epimedium wushanense Epimedium wushanense T.S.Ying or Herba Epimedii Epimedium koreanum Nakai.Tap when stem and leaf is luxuriant between summer, autumn, remove thick stalk and impurity, dry or dry in the shade.Nature and flavor suffering, sweet, temperature.Return liver, kidney channel.Has kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Be used for impotence and seminal emission, the muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension disease.

Zoopery confirms, this medical instrument has the sexual function improving effect, can also coronary blood flow increasing, lower peripheral vascular resistance, alleviate cardiac afterload, microcirculation improvement, and can resist acute myocardial ischemia damage and the experimental arrhythmia that pituitrin causes, reduce myocardial oxygen consumption, have the effect of blood pressure lowering and the effect of enhancing body nonspecific immunity defense function.

Hippocampus: be the dry body of Syngnathidae animal strain line Hippocampus Hippocampus kelloggi Jordan et Snyder, HIPPOCAMPUS Hippocampus histrix Kaup, big Hippocampus Hippocampus kuda Bleeder, hippocampus trimaculatus Leacs Hippocampus trimaculatus Leach or little Hippocampus (HAIQU) Hippocampusjaponicaus Kaup.Summer, Qiu Erji catch labor, clean, and dry; Or remove epithelium and internal organs, dry.Nature and flavor are sweet, temperature.Return liver, kidney channel.Has warming the kidney to invigorate YANG, mass dissipating and swelling eliminating.Be used for sexual impotence, the enuresis is suffered from a deficiency of the kidney and is made Chuan ， WEIJIA and gather injury from falling down; External treatment carbuncle furuncle.

Modern pharmacological research confirms that the rutting period of female mice can be brought out and prolong to Hippocampus, and the weight of uterus and ovary is increased, and can make male Mus prostate again. seminal vesicle. and the weight of levator ani obviously increases, and shows as androgen-like action.Hippocampus can strengthen the mice anoxia enduring again, reduces the activity of monoamine oxidase, MAO, reduces lipid peroxidation body content in vivo, and in addition, various Hippocampus extracts all have the effect of calcium channel blocker, by flowing in the blocking-up calcium, reaches the effect of neuroprotective unit.

Radix Ophiopogonis: be the dried root of liliaceous plant Ophiopogon Radix Ophiopogonis japonicus (Thunb.) Ker-Gawl..Excavate summer, cleans, and is exposed to the sun repeatedly, banks up, and to doing very likely, removes fibrous root, drying.This product is spindle, and two ends are point slightly, long 1.5～3cm, diameter 0.3～0.6cm.Surface yellow-white or faint yellow has thin longitudinal grin.Matter is pliable and tough, the section yellow-white, and translucent, center pillar is tiny.Feeble QI perfume (or spice), sweet, the little hardship of nature and flavor is slightly cold.GUIXIN, lung, stomach are through having YIN nourishing and the production of body fluid promoting, and lung moistening clears away heart-fire.Be used for dryness of the lung dry cough, the chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.

Rhizoma Polygonati: be the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati Polygonatum kingianum Coll.et Hemsl., Rhizoma Polygonati Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua.By the shape difference, practise title " big Rhizoma Polygonati ", " polygonatum sibiricum Redoute ", " RHIZOMA POLYGONATI ZINGIBERIFORME ".Spring, Qiu Erji excavate, and remove fibrous root, clean, and put the boiling water part omitted and scald or steam to the saturating heart, drying.Nature and flavor are sweet, and are flat.Return spleen, lung, kidney channel.Has boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.Be used for weakness of the spleen and stomach, fatigue and asthenia, the xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.

Pharmacological research shows that except that above-mentioned effect, Rhizoma Polygonati also has antibacterial action, especially tubercule bacillus and fungus is had significant effect, and the effect that brings high blood pressure down is arranged again simultaneously; Recent research shows that also Rhizoma Polygonati to coronary blood flow increasing, alleviates the atherosclerosis degree, and superoxide dismutase (S OD) activity has tangible effect in the raising liver.

Fructus Lycii: be the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Summer, two season of autumn gather when fruit is orange red, dry in the air to rhicnosis, tan by the sun again stiff to crust, sarcocarp is soft, removes carpopodium; Or the hot blast oven drying at low temperature, remove carpopodium.Nature and flavor are sweet, and are flat.Return liver, kidney channel.Has nourishing the liver and kidney, replenishing vital essence to improve eyesight.Be used for the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.The modern pharmacology experimentation shows that Fructus Lycii has the effect of anti-kidney aging.

Carapax et Plastrum Testudinis: be carapace and the sternite of Testudinidae animal Testudinis Chinemys reevesii (Gray).All can catch the whole year, with autumn, two seasons of winter be many, kill after the seizure, or scald deadly with boiling water, strip carapace and sternite, remove residual meat, dry.Nature and flavor and salty, sweet are slightly cold.Return liver, kidney, heart channel.Has nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, the reinforcing the heart of nourishing blood.Be used for deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat is had a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and the muscles and bones flaccidity is soft, and it is forgetful to have a guilty conscience.

The Radix Polygoni Multiflori: be the dried root of polygonum multiflorum thunb Polygonum multiflorum Thunb..Autumn, two season of winter excavate when leaf is withered, and the two ends of pruning are cleaned, individual big piece, the drying of being cut into.Nature and flavor hardship, sweet, puckery, temperature.Return liver, the heart, kidney channel.Has detoxifcation, eliminating carbuncle, loosening bowel to relieve constipation.Be used for the scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.

Through the whole bag of tricks the main nutrient composition content of the different goods of the Radix Polygoni Multiflori is measured, show and not only contain general nutrition such as a certain amount of crude protein, crude fat, free sugar and starch in the Radix Polygoni Multiflori, still be rich in the necessary trace element of multivitamin, aminoacid, inorganic salt and human body.Higher in the vitamin with vitamin B group content.Total amino acid content and Radix Panacis Quinquefolii are close, are many with glutamic acid, aspartic acid, arginine wherein.And contain multiple elements such as the necessary zinc of human body, magnesium, calcium, ferrum, and phospholipid composition.

Radix et Rhizoma Rhei: be the dry root and rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.The nature and flavor hardship, cold.Return spleen, stomach, large intestine, liver, pericardium channel.Has purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Be used for the excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.Be used for the conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay eliminating fire and detoxication.Be used for pathogenic fire,toxin and furuncles.The hemostasis of charred Radix Et Rhizoma Rhei cooling blood and removing stasis.Be used for heat in blood stasis of blood hemorrhage is arranged.

Studies show that emodin may suppress TNP by plain inhibitors of kinases p27 of raising cycle level.Induce kidney mesangial cell (mesangial eell, Mc) hypertrophy.

Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.The autumn art is excavated, and removes fibrous root and silt, treat that moisture evaporates slightly after, tie into wisp, last canopy is with pyrotechnics smoke-dried beancurd slowly.Nature and flavor are sweet, hot, temperature.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.The Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.Be used for the amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

Studies show that Radix Angelicae Sinensis not only has traditional pharmacological effects such as nourishing blood and promoting blood circulation, also has antioxidation, remove free radical, cholesterol reducing, the neontology effects such as information transmission adjusting of participation signaling system.

Rhizoma Acori Graminei: be the dry rhizome of acorus gramineus araceae plant Acorus tatarinowii Schott..Autumn, two seasons of winter excavate, and remove fibrous root and silt, dry.This product is oblate cylindricality, and is how crooked, and branch is often arranged, long 3～20cm, diameter 0.3～1cm.Surface sepia or taupe brown, coarse, link of uneven density is arranged, the long 0.2～0.8cm of internode, the thin longitudinal grin of tool, residual fibrous root of one side or round point shape root trace; Leaf scar is triangular in shape, about arrange the flaky phyllopodium remnants of hairiness on its that has alternately.Matter is hard, section fibrous, and off-white color or blush, the endodermis ring is obvious, visible most vascular bundle points and brown oil cell.Gas fragrance, nature and flavor suffering, hardship, temperature.GUIXIN, stomach warp.Has the removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.It is not hungry to be used for the gastral cavity painful abdominal mass, mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.

Herba Verbenae: be the aerial parts of Verenaceae plant Herba Verbenae Verbena officinalis L..Perennial herb, high 30～80cm usually.Stem top is square, old rear lower subcircular.Leaf is to life, and is avette to short circular, long 2～8cm, and wide 1～4cm, there is coarse wool on the two sides, and there is the rough sawn tooth at the edge or incises, the stem leaf stockless, most 3 drastic cracks, plumage splits sometimes, and there is irregular sawtooth at the sliver edge.The spike top is given birth to or is born in the top axil, and usually like horsewhip, every flower has 1 bract when blooming, and bract is slightly shorter than calyx, the outside hairiness; The calyx tubulose, 5 fissures; The corolla tubulose, lavender or blueness, nearly 2 lips; Stamen 4, the last two; Ovary Room 4, every chamber 1 ovule.Be split into 4 oblong pyrenes when ripe.6～August of florescence, really 7～November of phase.Cool in nature, bitter in the mouth.Herb contains venbenalin verbenalin) ey 5-hydroxy herba verbenae glycoside; Other contains emulsin, tannin; Leaf contains gland glycoside (adenoside), beta-carotene again.Has promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, detoxifcation, inducing diuresis to remove edema.Be used for lump in the abdomen, amenorrhea dysmenorrhea, malaria, sore throat, carbuncle, edema, pyretic stranguria.

The present invention adopts the following raw material of Chinese medicine (every pair of Chinese medicine) of following weight proportioning:

Hippocampus 0.3-3g, Rhizoma Anemarrhenae 6-20g, Radix Ophiopogonis 6-18g, Rhizoma Polygonati 9-30g, Fructus Lycii 9-30g, Rhizoma Coptidis 3-12g, Carapax et Plastrum Testudinis 9-30g, Radix Polygoni Multiflori 9-30g, Radix Et Rhizoma Rhei 3-15g, Herba Epimedii 9-30g, Radix Angelicae Sinensis 6-20g, Rhizoma Acori Graminei 9-30g, Herba Verbenae 9-30g,

By the preparation of following method: after Carapax et Plastrum Testudinis added 3 times of amounts of water and decoct 1 hour, leaching filtrate, residue adds all medical materials except that Hippocampus again, adds 8,6 times of amounts of water and extracts secondary, each 1.5 hours, filter, merging filtrate is concentrated into relative density and is about at 1.35 o'clock, and oven drying adds through being ground into the Hippocampus powder of fine powder to dry extract, cross 60 mesh sieves, filled capsules, be pressed into tablet or make granule.

Preparing pharmaceutical composition raw material of Chinese medicine preferred weight proportioning of the present invention is

Hippocampus 0.6-2.4g, Rhizoma Anemarrhenae 9-18g, Radix Ophiopogonis 9-15g, Rhizoma Polygonati 12-27g, Fructus Lycii 12-27g, Rhizoma Coptidis 6-9g, Carapax et Plastrum Testudinis 12-27g, Radix Polygoni Multiflori 12-27g, Radix Et Rhizoma Rhei 6-12g, Herba Epimedii 12-24g, Radix Angelicae Sinensis 9-15g, Rhizoma Acori Graminei 12-24g, Herba Verbenae 15-27g,

Pharmaceutical composition of the present invention through clinic trial in the diagnosis and treatment high insulin polycystic ovary syndrome; Yin deficiency and blood stasis phlegm-damp card persons such as the amenorrhea of excessive androgen type anovulation, companion's hyperinsulinemia, with clomiphene is treated the hundreds of examples of reactionless patient, the result shows, the fat Cervical of epigastrium back, oxter and pudendum part skin crude melanin calmness (black sour jujube skin phenomenon), hirsutism, symptom such as xerostomia, vexed or constipation, tongue are dark red takes an evident turn for the better or alleviates.

The specific embodiment

Embodiment 1

Get by following weight,

Hippocampus 0.3g, Rhizoma Anemarrhenae 6g, Radix Ophiopogonis 6g, Rhizoma Polygonati 9g, Fructus Lycii 9g, Rhizoma Coptidis 3g, Carapax et Plastrum Testudinis 9g, Radix Polygoni Multiflori 9g, Radix Et Rhizoma Rhei 3g, Herba Epimedii 9g, Radix Angelicae Sinensis 6g, Rhizoma Acori Graminei 9g, Herba Verbenae 9g,

After Carapax et Plastrum Testudinis added 3 times of amounts of water and decoct 1 hour, leaching filtrate, residue adds all medical materials except that Hippocampus again, adds 8,6 times of amounts of water and extracts secondary, each 1.5 hours, filter, merging filtrate is concentrated into relative density and is about at 1.35 o'clock, and oven drying adds through being ground into the Hippocampus powder of fine powder to dry extract, cross 60 mesh sieves, filled capsules.

Embodiment 2

Get by following weight,

Hippocampus 3 g, Rhizoma Anemarrhenae 20g, Radix Ophiopogonis 18g, Rhizoma Polygonati 30g, Fructus Lycii 30g, Rhizoma Coptidis 12g, Carapax et Plastrum Testudinis 30g, Radix Polygoni Multiflori 30g, Radix Et Rhizoma Rhei 15g, Herba Epimedii 30g, Radix Angelicae Sinensis 20g, Rhizoma Acori Graminei 30g, Herba Verbenae 30g,

After Carapax et Plastrum Testudinis added 3 times of amounts of water and decoct 1 hour, leaching filtrate, residue adds all medical materials except that Hippocampus again, adds 8,6 times of amounts of water and extracts secondary, each 1.5 hours, filter, merging filtrate is concentrated into relative density and is about at 1.35 o'clock, and oven drying adds through being ground into the Hippocampus powder of fine powder to dry extract, cross 60 mesh sieves, make granule.

Embodiment 3

Get by following weight,

Hippocampus 0.6g Rhizoma Anemarrhenae 18g 15g Radix Ophiopogonis

Rhizoma Polygonati 12g Fructus Lycii 12g Rhizoma Coptidis 9g

Carapax et Plastrum Testudinis 15g Radix Polygoni Multiflori 27g Radix Et Rhizoma Rhei 6g

Herba Epimedii 24g Radix Angelicae Sinensis 15g Rhizoma Acori Graminei 18g

Herba Verbenae 27g

Preparation method: after Carapax et Plastrum Testudinis added 3 times of amounts of water and decoct 1 hour, leaching filtrate, residue adds all medical materials except that Hippocampus again, adds 8,6 times of amounts of water and extracts secondary, each 1.5 hours, filter, merging filtrate is concentrated into relative density and is about at 1.35 o'clock, and oven drying adds through being ground into the Hippocampus powder of fine powder to dry extract, cross 60 mesh sieves, be pressed into tablet.

Embodiment 4

Get by following weight,

Hippocampus 1g Rhizoma Anemarrhenae 9g 9g Radix Ophiopogonis

Rhizoma Polygonati 27g Fructus Lycii 27g Rhizoma Coptidis 6g

Carapax et Plastrum Testudinis 27g Radix Polygoni Multiflori 12g Radix Et Rhizoma Rhei 9g

Herba Epimedii 12g Radix Angelicae Sinensis 9g Rhizoma Acori Graminei 24g

Herba Verbenae 15g

Preparation method: after Carapax et Plastrum Testudinis added 3 times of amounts of water and decoct 1 hour, leaching filtrate, residue adds all medical materials except that Hippocampus again, adds 8,6 times of amounts of water and extracts secondary, each 1.5 hours, filter, merging filtrate is concentrated into relative density and is about at 1.35 o'clock, and oven drying adds through being ground into the Hippocampus powder of fine powder to dry extract, cross 60 mesh sieves, make granule.

Embodiment 5

Get by following weight,

Hippocampus 2.4g Rhizoma Anemarrhenae 12g 12g Radix Ophiopogonis

Rhizoma Polygonati 18g Fructus Lycii 18g Rhizoma Coptidis 9g

Carapax et Plastrum Testudinis 12g Radix Polygoni Multiflori 18g Radix Et Rhizoma Rhei 12g

Herba Epimedii 18g Radix Angelicae Sinensis 12g Rhizoma Acori Graminei 12g

Herba Verbenae 18g

Preparation method: after Carapax et Plastrum Testudinis added 3 times of amounts of water and decoct 1 hour, leaching filtrate, residue adds all medical materials except that Hippocampus again, adds 8,6 times of amounts of water and extracts secondary, each 1.5 hours, filter, merging filtrate is concentrated into relative density and is about at 1.35 o'clock, and oven drying adds through being ground into the Hippocampus powder of fine powder to dry extract, cross 60 mesh sieves, filled capsules.

Claims (7)

1, a kind of pharmaceutical composition for the treatment of high insulin polycystic ovary syndrome is characterized in that adopting following raw materials by weight proportions to make (every pair of Chinese medicine):

Hippocampus 0.3-3g, Rhizoma Anemarrhenae 6-20g, Radix Ophiopogonis 6-18g, Rhizoma Polygonati 9-30g, Fructus Lycii 9-30g, Rhizoma Coptidis 3-12g, Carapax et Plastrum Testudinis 9-30g, Radix Polygoni Multiflori 9-30g, Radix Et Rhizoma Rhei 3-15g, Herba Epimedii 9-30g, Radix Angelicae Sinensis 6-20g, Rhizoma Acori Graminei 9-30g, Herba Verbenae 9-30g.

2, by the pharmaceutical composition of the described treatment high insulin polycystic ovary syndrome of claim 1, wherein the weight proportion of each raw material is:

Hippocampus 0.6-2.4g, Rhizoma Anemarrhenae 9-18g, Radix Ophiopogonis 9-15g, Rhizoma Polygonati 12-27g, Fructus Lycii 12-27g, Rhizoma Coptidis 6-9g, Carapax et Plastrum Testudinis 12-27g, Radix Polygoni Multiflori 12-27g, Radix Et Rhizoma Rhei 6-12g, Herba Epimedii 12-24g, Radix Angelicae Sinensis 9-15g, Rhizoma Acori Graminei 12-24g, Herba Verbenae 15-27g.

3, by the pharmaceutical composition of the described treatment high insulin polycystic ovary syndrome of claim 1, wherein the weight proportion of each raw material is:

Hippocampus 0.6g Rhizoma Anemarrhenae 18g 15g Radix Ophiopogonis

Rhizoma Polygonati 12g Fructus Lycii 12g Rhizoma Coptidis 9g

Carapax et Plastrum Testudinis 15g Radix Polygoni Multiflori 27g Radix Et Rhizoma Rhei 6g

Herba Epimedii 24g Radix Angelicae Sinensis 15g Rhizoma Acori Graminei 18g

Herba Verbenae 27g.

4, by the pharmaceutical composition of the described treatment high insulin polycystic ovary syndrome of claim 1, wherein the weight proportion of each raw material is:

Hippocampus 1g Rhizoma Anemarrhenae 9g 9g Radix Ophiopogonis

Rhizoma Polygonati 27g Fructus Lycii 27g Rhizoma Coptidis 6g

Carapax et Plastrum Testudinis 27g Radix Polygoni Multiflori 12g Radix Et Rhizoma Rhei 9g

Herba Epimedii 12g Radix Angelicae Sinensis 9g Rhizoma Acori Graminei 24g

Herba Verbenae 15g.

5, by the pharmaceutical composition of the described treatment high insulin polycystic ovary syndrome of claim 1, wherein the weight proportion of each raw material is:

Hippocampus 2.4g Rhizoma Anemarrhenae 12g 12g Radix Ophiopogonis

Rhizoma Polygonati 18g Fructus Lycii 18g Rhizoma Coptidis 9g

Carapax et Plastrum Testudinis 12g Radix Polygoni Multiflori 18g Radix Et Rhizoma Rhei 12g

Herba Epimedii 18g Radix Angelicae Sinensis 12g Rhizoma Acori Graminei 12g

Herba Verbenae 18g.

6, the pharmaceutical composition by the described treatment high insulin polycystic ovary syndrome of claim 1 is characterized in that its dosage form of described pharmaceutical composition is capsule, tablet or granule.

7, press the preparation of drug combination method of the described treatment high insulin polycystic ovary syndrome of claim 1, it is characterized in that being undertaken: after Carapax et Plastrum Testudinis is added 3 times of amounts of water and decocts 1 hour by following step, leaching filtrate, residue adds all medical materials except that Hippocampus again, add 8,6 times of amounts of water and extract secondary, each 1.5 hours, filter, merging filtrate is concentrated into relative density and is about 1.35, oven drying is to dry extract, adding is crossed 60 mesh sieves through being ground into the Hippocampus powder of fine powder, filled capsules, is pressed into tablet or makes granule.