CN102302669B - Traditional Chinese medicine composition for treating kidney-yin deficiency and phlegm-blood stasis polycystic ovary syndrome (PCOS) - Google Patents
Traditional Chinese medicine composition for treating kidney-yin deficiency and phlegm-blood stasis polycystic ovary syndrome (PCOS) Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating kidney-yin deficiency and phlegm-blood stasis polycystic ovary syndrome (PCOS). The traditional Chinese medicine composition comprises the medicinal materials such as anemarrhena, fritillary bulb, tortoise plastron, radix polygoni multiflori preparata, lilyturf root, hippocampus and the like. The medicinal materials are cooperative with each other so as to realize the efficacies of nourishing kidney and clearing away heat and reducing phlegm and removing blood stasis. The traditional Chinese medicine composition has the advantages of reducing the level of androgens and androgen receptors of patients suffering from PCOS, improving the level of sex hormone-binding globulin (SHBG), lowering the level of free testosterone (F-TESTO), further raising the level of in-vivo estrogens, improving growth and development of follicles and increasing ovulation rate and pregnancy rate of the patients.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition that is used for the treatment of polycystic ovarian syndrome, relate in particular to a kind of by several kinds of Chinese medicinal materials by monarch, minister, help, make compatible pharmaceutical composition, be used for the Chinese medicine composition of deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome.
Background technology
Polycystic ovarian syndrome (Polycystic Ovary Syndrome, PCOS) proposed in nineteen thirty-five by Stein and Leventhal, refer to have menoxenia, amenorrhea, anovulation, hirsutism, obesity, infertile merging bilateral ovaries increase a class disease that is the performances such as polycystic change.This disease is the common endocrinopathy of women and mostly causes dysgenesia, and its sickness rate accounts for the women of child-bearing age's 5%-10%.Research in recent years recognizes that extensively there is insulin resistant in various degree in the women of PCOS, and the insulin resistant hyperinsulinemia that occurs together causes many clinical symptoms, as: androgen levels is too high, reproduction is disorderly, metabolism disorder, acne and hirsutism etc.Suffer from women's arteriosclerosis of PCOS and the risk factor increase of cardiovascular disease incidence owing to there being insulin resistant.Think that at present PCOS patient's insulin resistant (IR) mainly occurs in the classical target organ of insulin action---skeletal muscle, fat and liver etc., and reproduction abnormality mainly occurs in ovary tissue.
The syndromic genetics research of Stein-Leventhal was just proposed as far back as the thirties in last century, the foundation of diagnosis concentrates on the feature of polycystic ovary, it is polymorphism that the people such as Goldzicher in 1962 and Green have proposed clinical manifestation, and therapeutic effect is also polymorphic.Produced laboratory diagnosis standard along with radioimmunoassay technique carries out the seventies: lutropin/follicule-stimulating hormone (FSH) (LH/FSH)＞3 is emphasized in diagnosis, change into later on 〉=2.5.Rotterdam meeting U.S. reproductive medicine in 2003 can and the European mankind's reproductive medicine diagnostic criteria of PCOS can be proposed, possessing in following 32 can set up: (1) oligo-ovulation or do not ovulate; (2) clinical or biochemical excessive androgen performance; (3) ultrasonoscopy Ovarian Volume＞10ml, or the follicle of visible 〉=12 diameter 2-9mm.The history of the existing last 100 years of the understanding of relevant polycystic ovarian syndrome, its diagnostic criteria changes with the epoch transition, and molecule genetics research has so far generally acknowledged that PCOS is a polygenic disease.2006 Nian Yujin professor combination Chinese and western medicine clinical practices for many years, around the too high core of PCOS androgen, proposed diagnostic point: (1) androgen is too high: have clinical or biochemical indicator (T or logT/E
2), can determine by the clinical manifestation performance the corresponding biochemical indicator of this mensuration; (2) anovular menstruation, infrequent menstruation, amenorrhea or anovulatory dysfunctional uterine hemorrhage: after menophania, can regular menstrual onset, but painless warp or menstrual period are uncomfortable, the basal body temperature individual event; Or infrequent menstruation, amenorrhea, small number of patients has the anovulatory dysfunctional uterine hemorrhage phenomenon; Sterile; (3) polycystic ovary is seen in ultrasonoscopy: Ovarian Volume＞6ml, the follicle of a visible diameter 2-10mm in plane＞10 meets above 3 simultaneously, and gets rid of congenital adrenal cortical hyperplasia and the diseases such as ovary or adrenal gland neoplasms.
The common western medicine therapy of PCOS mainly uses contraceptive or promoting ovulation drug, receives sweet smell, Marvelon and Da Ying etc. as: clomiphene, HMG, GnRH, fruit.These medicines not only can not be realized effectively treatment to all PCOS, also have the defectives such as low pregnancy rate and high abortion ratio.The surgery puncture technique also is applied to the treatment of PCOS, and these therapies may be to the ovary injury, or causes pelvic adhesion and fetus is had potential harm.
The traditional Chinese medical science is also treated PCOS from its peculiar understanding and medication angle, as: name is called the prescription of " growing the water Yishen Tang ", and its ingredients is: Radix Puerariae 30 grams, fresh Herba Dendrobii 12 grams, Radix Trichosanthis 10 grams, Endothelium Corneum Gigeriae Galli 15 grams, Semen Sinapis Albae 10 grams, Radix Cyathulae 15 grams, Fructus Schisandrae Chinensis 5 grams, Radix Angelicae Sinensis 10 grams, Radix Paeoniae Alba (parched) 10 grams, Radix Curcumae 10 grams, Radix Dipsaci 15 grams and Rhizoma Polygoni Cuspidati 15 grams.The people such as Yu Jin are using for reference theory of Chinese medical science, have obtained " Yu Shi temperature compensation ball " by practice, and the induced ovulation rate is 82.7% in treatment PCOS, pregnancy rate 50%.Further studies confirm that, " Yu Shi temperature compensation ball " has the PCOS patient of reduction androgen, thereby the secretion that has improved follicule-stimulating hormone (FSH) causes the effect of ovulating.
Summary of the invention
one object of the present invention is to provide a kind of Chinese medicine composition for deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome, to improve patient's xerostomia, vexed, leucorrhea reduces, fat, acne, hair oil, the clinical symptoms such as anovulation, and androgen and the Androgen Receptor Level that reduces PCOS patient arranged, improve sex hormone binding protein (Sex Hormone-Binding Globulin, SHBG) level, reduce the effect of free testosterone level, thereby further improve body inner estrogen level, improve the growth promoter of follicle, improve patient's ovulation rate and pregnancy rate.
Another object of the present invention is to provide a kind of preparation that contains the Chinese medicine composition that is useful on deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome.
" the deficiency of the kidney yin phlegm and blood stasis " that the present invention is alleged, cardinal symptom is few except the delayed menstrual cycle amount, amenorrhea or infertile, simultaneously, abundant expectoration few with xerostomia, vexed, interior-heat, leucorrhea, constipation, tongue is dark red, few tongue and thready and rapid pulse etc.The present invention take the cloudy clearind deficient heat of kidney tonifying as main, reduces the consumption of essence and blood in kidney thus, and the product that being aided with reduces phlegm invigorates blood circulation are so that equilibrium between yin and yang in kidney rushes to appoint and fills Sheng, menstruation self-regulated.
Alleged " patient " of the present invention refers to suffer from people, wild animal and the domestic animal (Livestock) of disease.Wild animal is without domestication's animal under naturalness.Domestic animal is the animal of the artificial breeding for food source is provided, as: monkey, ape, Canis familiaris L., Mus, hamster, pig, rabbit, horse, milch cow, Babalus bubalis L., bull, sheep and goat etc." patient " that diagnose preferentially selects mammal, especially people.
The Rhizoma Anemarrhenae is the rhizome of Liliaceae (Liliaceae) the plant Rhizoma Anemarrhenae (Anemarrhena asphodeloides Bunge), cold in nature, bitter in the mouth, sweet is returned lung, harmonization of the stomach kidney channel, the effect that has nourishing YIN to lower pathogenic fire and moisturize laxation, tcm clinical practice is multiplex in diabete.Its chemical composition that mainly contains has flavonoid, icariin, icariine, 3,5,7-trihydroxy-2-(4-methoxy-phenyl)-8-(3-methyl-but-2-enyl)-chromen-4-one, and the volatile oil such as the acid of leaf fiber crops, oleic acid, Palmic acid, also contains the materials such as sterin, benzene, tannic acid, vitamin E and flavone.Herb or the leaf of XIAONIE section plant Herba Epimedii taken from its crude drug source, enters medicinal its stem and leaf, the preferential fresh leaf of selecting with cyan of medical material.
Bulbus Fritillariae Uninbracteatae, cold nature, bitter in the mouth, sweet is returned lung and the heart two warps.Its bulb hyoscine has the effect of relieving cough and resolving phlegm, heat clearing away eliminating stagnation.Can be divided into Bulbus Fritillariae Cirrhosae, Bulbus Fritillariae Thunbergii (Bulbus Fritillariae Thunbergii) and Rhizoma Bolbostematis three major types, different Bulbus Fritillariae Uninbracteatae effects also there are differences.Bulbus Fritillariae Cirrhosae is slightly cold, sweet in the mouth, and the relieving cough and resolving phlegm effect is stronger, and the effect of lung moistening is arranged, and abundant expectoration expectorant all can use less, is specially adapted to the cough due to the dryness of the lung or autumn-dryness disease.The patient shows as cough, and, difficulty few with expectorant coughed up, or the discomfort such as sputum mixed with blood, mouth and nose drying, dry throat and mouth.If the patient shows as cough chest pain, fever with aversion to cold, cough tell stench purulent sputum, be hard and dry, during the symptom such as red tongue xerostomia, should select Bulbus Fritillariae Thunbergii, because the effect of Bulbus Fritillariae Thunbergii pathogenic fire purging is better than Bulbus Fritillariae Cirrhosae, and being good at the eliminating stagnation of relieving inflammation or internal heat, is the good medicine for the treatment of lung abscess.For take cough, unfavorable, the expectorant of expectoration yellow sticky, xerostomia is thirsty, the red cough due to pathogenic wind-heat patient as main manifestations of tongue fur, both can select Bulbus Fritillariae Cirrhosae, can select Bulbus Fritillariae Thunbergii again.Because of the Bulbus Fritillariae Cirrhosae this medicine is mild, abnormal smells from the patient is not dense, is more suitable for taking in the elderly and infirm.And for children's and adolescence that plain body heat is contained, preferably select Bulbus Fritillariae Thunbergii.Rhizoma Bolbostematis, cold in nature, bitter in the mouth has stronger antiinflammatory, antiviral and antineoplastic action, normal uses treatment breast disease, tuberculosis and the skin disease such as rotten that swells with other heat-clearing and toxic substances removing medicine compatibilities.The alleged Bulbus Fritillariae Uninbracteatae of the present invention is Bulbus Fritillariae Cirrhosae and Bulbus Fritillariae Thunbergii.
Carapax et Plastrum Testudinis, cold nature, salty in the mouth, sweet is returned liver, kidney and heart channel.Also claim Carapax et Plastrum Testudinis, Carapax et Plastrum Testudinis, raw tortoise plastron, stir-fry Carapax et Plastrum Testudinis, Carapax Et Plastrum Testudinis (processed), vinegar Carapax et Plastrum Testudinis, Colla Plastri Testudinis and stir-baked PLASTRUM TESTUDINIS then treated with vinegar etc. in tcm prescription, sternite and carapace for Testudinidae animal (chinemys reevesii), have the effects such as nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening and the reinforcing the heart of nourishing blood, consumption is generally the 9-24 weight portion.In medical this cure mainly the diseases such as deficiency of kidney yin, hectic fever due to YIN-deficiency consumptive fever, haematemesis, epistaxis, chronic cough, seminal emission, metrorrhagia, leukorrhagia, lumbago, the atrophic debility of bones, stirring of wind due to deficiency of YIN, chronic dysentery, chronic malaria, hemorrhoid and non-closure of fontanels jin infants.Conventional manufacture method as: with its execution, or scald deadly with boiling water, strip the shell first, remove residual meat, dry, use with quench in vinegar after husky stir-baking with sand.
The Radix Polygoni Multiflori is divided into Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata, and direct slicing is used as medicine and is Radix Polygoni Multiflori, mixes to dry to be used as medicine after steaming with the Semen sojae atricolor liquor to be Radix Polygoni Multiflori Preparata.Radix Polygoni Multiflori, property is flat, sweet in the mouth, hardship, GUIXIN, liver and large intestine channel; Radix Polygoni Multiflori Preparata, slightly warm in nature, sweet in the mouth, puckery is returned liver and kidney channel.Radix Polygoni Multiflori has the effect of detoxifcation, eliminating carbuncle and loosening bowel to relieve constipation, is usually used in treating the diseases such as scrofula carbuncle sore, rubella pruritus and dryness of the intestine constipation; Radix Polygoni Multiflori Preparata has the effect of invigorating the liver and kidney, benefiting essence-blood, black beard and hair and bone and muscle strengthening, is used for the treatment of the diseases such as blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses and chronic malaria body void.
Radix Angelicae Sinensis, warm in nature, sweet in the mouth, suffering are returned liver, the heart and spleen channel, have another name called that Radix Angelicae Sinensis, cloud are returned, western Radix Angelicae Sinensis and Min Radix Angelicae Sinensis etc., are the dry root of umbelliferae angelica (Angelica sinensis (Oliv.) Diels).The traditional Chinese medical science is thought, Radix Angelicae Sinensis have enrich blood invigorate blood circulation, the effect of menstruction regulating and pain relieving and loosening bowel to relieve constipation, be usually used in treating blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, apoplexy syncope, spit out white foams, puerperal paralysis and the disease such as ulcer sores, consumption is generally the 6-12 weight portion.Radix Angelicae Sinensis (processed with wine) has promoting blood circulation to restore menstrual flow, can be used for the amenorrhea dysmenorrhea, rheumatic arthralgia and injury from falling down.
Radix Ophiopogonis, cold nature, sweet in the mouth, little hardship, GUIXIN, lung, stomach warp, tcm prescription also claims Radix Ophiopogonis, Radix Ophiopogonis, RADIX OPHIOPOGONIS from Hangzhou of China, Zhejiang Radix Ophiopogonis, Radix Ophiopogonis, very little Radix Ophiopogonis, the Radix Ophiopogonis of processing, Radix Ophiopogonis, Zhu's Radix Ophiopogonis, occasion Radix Ophiopogonis, occasion Radix Ophiopogonis, bright Radix Ophiopogonis and stir and mix with CINNABARIS Radix Ophiopogonis etc., is the dried root of liliaceous plant Radix Ophiopogonis (Ophiopogon japonicus (L.f) Ker-Gawl).Have nourishing YIN and moistening the lung Radix Ophiopogonis, the effect of clear away heart-fire relieving restlessness and reinforcing stomach reg fluid, be usually used in treating dryness of the lung dry cough, haematemesis, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, quench one's thirst, the disease such as calentura Tianjin wound, dry mouth and throat and constipation, consumption is the 2-4 weight portion.
A kind of Chinese medicine composition for deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome provided by the invention comprises
Monarch drug: the Bulbus Fritillariae Uninbracteatae of the Rhizoma Anemarrhenae of weight portion 9-21 and weight portion 9-24; Ministerial drug: weight portion is that the Carapax et Plastrum Testudinis of 9-21, the Radix Polygoni Multiflori Preparata that weight portion is 12-24, Radix Angelicae Sinensis and the weight portion that weight portion is 9-21 are the Radix Ophiopogonis of 9-24; Adjuvant drug: weight portion is the Hippocampus of 0.3-15.
In addition, Spina Gleditsiae is warm in nature enters lung and large intestine channel, phlegm reduction of blood circulation promoting, promoting blood circulation; The bitter temperature of Rhizoma Acori Graminei enters the heart and Liver Channel, reduces phlegm except stopping up, and refreshes oneself sensible.Chinese medicine composition of the present invention adds Spina Gleditsiae and Rhizoma Acori Graminei further to improve the therapeutic effect of compositions again.
Another kind provided by the invention is used for the Chinese medicine composition of deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome, comprises
Monarch drug: the Bulbus Fritillariae Uninbracteatae of the Rhizoma Anemarrhenae of weight portion 9-21 and weight portion 9-24; Ministerial drug: weight portion is that the Carapax et Plastrum Testudinis of 9-21, the Radix Polygoni Multiflori Preparata that weight portion is 12-24, Radix Angelicae Sinensis and the weight portion that weight portion is 9-21 are the Radix Ophiopogonis of 9-24; Adjuvant drug: weight portion is that the Hippocampus of 0.3-15, Spina Gleditsiae and the weight portion that weight portion is 9-21 are the Rhizoma Acori Graminei of 9-21.
PCOS patient usually also be attended by such as: weak fatiguability, obesity, have expectorant, oral ulcer, insomnia, mammary swelling, hyperhidrosis, stomach upset, merging pelvic inflammatory disease, endometriosis and tongue that the clinical manifestations such as the stasis of blood are secretly arranged, therefore need to be in conjunction with actual state of an illness increase simply or the multi-flavor medical material.
Weak fatiguability, mostly take the deficiency of vital energy as main, the Chinese crude drug that need to re-use invigorating the spleen and benefiting QI as: but be not limited only to, Radix Codonopsis, the Radix Astragali, Radix Pseudostellariae and Rhizoma Dioscoreae, consumption is the 9-30 weight portion.
Obesity, how by deficiency of the kidney yin, deficiency-fire produced in the interior, refining liquid becomes expectorant, overflows skin and causes, often need again Chinese crude drug that compatibility uses drying dampness to eliminate phlegm as: but be not limited only to, Rhizoma Pinelliae Preparata, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Poria, Rhizoma Alismatis and Folium Nelumbinis, consumption are the 6-24 weight portion.
Expectorant is arranged in pharynx, how by blockage of qi mechanism by phlegm, disturbance of lung-QI and causing, the Chinese crude drug that often needs again the compatibility phlegm-eliminiating and qi-regulating as: but be not limited only to, Thallus Laminariae (Thallus Eckloniae), Sargassum, Rhizoma Pinelliae Preparata, Pericarpium Citri Reticulatae, Pericarpium Trichosanthis and Bulbus Allii Macrostemonis, consumption are the 6-21 weight portion.
How oral ulcer damages the moon for a long time by disease, due to hyperactivity of deficient fire, the Chinese crude drug that often needs again the compatibility nourishing YIN and clearing away fire as: but be not limited only to, the Rhizoma Anemarrhenae and Cortex Phellodendri, consumption is the 6-24 weight portion.
Insomnia, how by imbalance of YIN and YANG, due to disarmony between the heart and kidney, often need again Chinese crude drug that compatibility calms the nerves as: but be not limited only to, Semen Ziziphi Spinosae, Semen Platycladi, Magnetitum, Concha Haliotidis, Cortex Albiziae and Caulis Polygoni Multiflori, consumption are the 6-30 weight portion.
Mammary swelling, how by the liver failing to maintain the normal flow of QI, due to newborn network is obstructed, the Chinese crude drug that often needs again compatibility depressed liver-energy dispersing and QI regulating collateral dredging as: but be not limited only to, Pericarpium Citri Reticulatae Viride, Radix Bupleuri, Cortex Moutan and Semen Vaccariae, consumption are the 6-24 weight portion.
Merge pelvic inflammatory disease person, the card that damp invasion of lower energizer is arranged more, the Chinese crude drug that often needs again the compatibility heat-clearing and toxic substances removing as: but be not limited only to, Pollen Typhae, Herba Taraxaci, Rhizoma Curcumae, Herba Patriniae, Herba Violae, Radix Sophorae Tonkinensis, Flos Lonicerae, Fructus Forsythiae, Herba Commelinae, Rhizoma Osmundae, Rhizoma Paridis, Rhizoma Smilacis Glabrae and Rhizoma Paridis, consumption are the 6-30 weight portion.
Merge the endometriosis person, the card that stops in blood stasis is arranged more, the Chinese crude drug that often needs again compatibility blood circulation promoting and blood stasis dispelling Xiao Disorder as: but be not limited only to, Hirudo, Rhizoma Curcumae, Olibanum, Myrrha, Eupolyphaga seu steleophaga, Pollen Typhae, Semen Persicae, rhizoma sparganic, Scolopendra and Pheretima, consumption is the 2-24 weight portion.
Hyperhidrosis, how by the deficiency of vital energy, can not astringency inducing or the deficiency of YIN, due to the rising body fluid of interior-heat leaks, the Chinese crude drug that often needs again the astringent or styptic treatment for spontaneous sweating arresting sweating of compatibility as: but be not limited only to, Concha Ostreae, Fructus Tritici Levis and Radix Ephedrae, consumption are the 9-30 weight portion.
Stomach upset, how by due to disorder of stomach-QI, the Chinese crude drug that often needs again the compatibility regulating qi-flowing for harmonizing stomach as: but be not limited only to, Fructus Evodiae, Radix Aucklandiae (Radix Vladimiriae) and Fructus Amomi, consumption are the 3-15 weight portion.
Tongue secretly has the stasis of blood, how by caused by energy stagnation and blood stasis, the Chinese crude drug that often needs again the compatibility blood circulation promoting and blood stasis dispelling as: but be not limited only to, Semen Persicae, consumption are the 6-21 weight portion.
Chinese medicine composition for deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome provided by the invention is made decoction by decocting method, or makes unguentum by traditional Chinese medical science traditional method.
The beneficial effect that technical solution of the present invention realizes:
Chinese medicine composition for deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome provided by the invention comprises the medical materials such as the Rhizoma Anemarrhenae, Bulbus Fritillariae Uninbracteatae, Carapax et Plastrum Testudinis, the Radix Polygoni Multiflori, Radix Ophiopogonis and Hippocampus, ingredients work in coordination nourishing kidney and clearing heat, dissipating phlegm and removing blood stasis.Give to PCOS patient decoction or the unguentum that Chinese medicine composition of the present invention is made, after taking a period of time, patient's androgen levels significantly reduces, and the growth promoter of follicle improves, and has improved patient's ovulation rate and pregnancy rate.But Chinese medicine composition nourishing kidney and clearing heat of the present invention, dissipating phlegm and removing blood stasis be with regulating menstruation, be used for clinical manifestation take xerostomia, vexed, interior-heat, constipation, leukorrhagia is few, tongue is dark red, few tongue and thready and rapid pulse etc. are as main deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome patient.
The specific embodiment
Below describe technical scheme of the present invention in detail.The embodiment of the present invention is only unrestricted in order to technical scheme of the present invention to be described, although with reference to preferred embodiment, the present invention is had been described in detail, those of ordinary skill in the art is to be understood that, can modify or be equal to replacement the technical scheme of invention, and not breaking away from the spirit and scope of technical solution of the present invention, it all should be encompassed in claim scope of the present invention.
Embodiment of the present invention medical material used is dated except separately having, and all can obtain from Chinese crude drug sales company.The medical material that obtains is dated except separately having, and is tcm and herbal slice.Decoction pieces both can obtain from sales company, can be also to obtain by processing.
The preparation of embodiment 1 decoction
Get Rhizoma Anemarrhenae 15g, Bulbus Fritillariae Uninbracteatae 12, Radix Polygoni Multiflori Preparata 24g, Radix Ophiopogonis 12g, Carapax et Plastrum Testudinis 12g, Hippocampus 0.6g, Radix Angelicae Sinensis 9g, Spina Gleditsiae 15g and Rhizoma Acori Graminei 15g, soak more than 2 hours in container after water rinses, then adopt and be decocted first and rear lower traditional fried technique, the normal pressure decoction leached medicinal liquid in 20 minutes.
The preparation of embodiment 2 unguentum
Get Rhizoma Anemarrhenae 150g, Bulbus Fritillariae Uninbracteatae 120, Radix Polygoni Multiflori Preparata 260g, Radix Ophiopogonis 120g, Carapax et Plastrum Testudinis 120g, Hippocampus 6g, Radix Angelicae Sinensis 90g, Spina Gleditsiae 150g and Rhizoma Acori Graminei 150g, soak more than 2 hours in container after water rinses, then adopt be decocted first and rear under traditional fried technique, normal pressure leaches medicinal liquid and concentrating under reduced pressure medicinal liquid after decocting, in the medicinal liquid concentration process, add the required saccharide such as crystal sugar, maltose and yellow wine and necessary adjuvant, stir and receive cream.
Embodiment 3 clinical observations
Deficiency of the kidney yin intermingled phlegm and blood stasis type patient includes in by following standard:
A) Western medicine diagnose standard: 1) menstrual onset is still anovulatory menstruation (BBT is single-phase), infrequent menstruation or amenorrhea more than 2 years; 2) the blood androgen raises: metrorrhagia the 3rd day, testosterone (T) raises or testosterone/estradiol logarithm ratio (Log (T/E
2))＞0.97; Can merge 17 α-hydroxyprogesterone (17 α-OHP) increase with androstenedione; 3) ultrasound diagnosis find Ovarian Volume increase (〉=6ml), the follicle number of diameter 2～9mm on plane in cortex＞10.
B) Syndrome Differentiation of Traditional Chinese Medicine standard: the few or amenorrhea except the delayed menstrual cycle amount, infertile, the companion sees that xerostomia, vexed, interior-heat, leukorrhagia are few, constipation etc., tongue is dark red, tongue is few, thready and rapid pulse.
Adopt Chinese medicine composition decoction of the present invention to treat to the patient who includes in by above-mentioned standard, and before and after treating, every lab index of patient detects, and observe (seeing Table 1) with regard to clinical symptoms, take to treat the cross-reference mode and judge effects of clinic diagnosis.
Observe and find: after treatment in 2～3 months, patient's menstruation obviously improve the time, General Symptoms (as: obesity, xerostomia, vexed, leucorrhea reduces and hair greasy etc.), emotion and energy also is clearly better, most of pigmentation patient obviously disappear (seeing Table 2).The ovulation rate of being controlled the patient reaches 89.7%, and pregnancy rate is 50% (seeing Table 1).
Blood androgen that lab testing is found patient after treatment is as 17 α hydroxyprogesterones, testosterone (T), logT/E
2Level obviously descends; Estradiol level obviously rise (seeing Table 3).
Table 1
In table 1, clinical cure refers to that gestation or menstruation monthly rise, and occurs continuously 3 ovulations in half a year; Weight loss simultaneously, the General Symptomies such as xerostomia, vexed, leucorrhea minimizing obviously improve; Produce effects refers to that menstruation rose once in 30～45 days, and 2 ovulations were arranged in half a year, and General Symptoms obviously improves; Effectively the finger menstruation is risen once for 1～February, and 1 ovulation was arranged in half a year, and General Symptoms improves; Invalid finger menstruation can be risen, the anovulation phenomenon, and General Symptoms improves.
Table 2
Wherein, " * * " expression and front relatively P＜0.01 for the treatment of.
Table 3
Wherein, " * " expression and front relatively P＜0.05 for the treatment of; Compare P＜0.01 before " * * " expression treatment.
After treatment, patient's blood estradiol level obviously rises (P＜0.05), testosterone, Log (T/E
2) and 17 α hydroxyprogesterone levels obviously descend (P＜0.01, P＜0.01, P＜0.01).Illustrate that patient body inner estrogen level rises, and the excessive androgen state makes moderate progress.
Claims (12)
1. a Chinese medicine composition that is used for deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome, is characterized in that comprising
Monarch drug: the Bulbus Fritillariae Uninbracteatae of the Rhizoma Anemarrhenae of weight portion 9-21, weight portion 9-24; With
Ministerial drug: weight portion is that the Carapax et Plastrum Testudinis of 9-21, the Radix Polygoni Multiflori Preparata that weight portion is 12-24, Radix Angelicae Sinensis, the weight portion that weight portion is 9-21 are the Radix Ophiopogonis of 9-24; With
Adjuvant drug: weight portion is the Hippocampus of 0.3-15, and
Spina Gleditsiae and Rhizoma Acori Graminei.
2. a Chinese medicine composition that is used for deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome, is characterized in that comprising
Monarch drug: the Bulbus Fritillariae Uninbracteatae of the Rhizoma Anemarrhenae of weight portion 9-21, weight portion 9-24; With
Ministerial drug: weight portion is that the Carapax et Plastrum Testudinis of 9-21, the Radix Polygoni Multiflori Preparata that weight portion is 12-24, Radix Angelicae Sinensis, the weight portion that weight portion is 9-21 are the Radix Ophiopogonis of 9-24; With
Adjuvant drug: weight portion is that the Hippocampus of 0.3-15, Spina Gleditsiae and the weight portion that weight portion is 9-21 are the Rhizoma Acori Graminei of 9-21.
3. one of according to claim 1-2 described Chinese medicine compositions for deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome, is characterized in that described Chinese medicine composition also comprises one or more of Radix Codonopsis, the Radix Astragali, Radix Pseudostellariae and Rhizoma Dioscoreae.
4. one of according to claim 1-2 described Chinese medicine compositions for deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome, is characterized in that described Chinese medicine composition also comprises one or more of Rhizoma Pinelliae Preparata, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Poria, Rhizoma Alismatis and Folium Nelumbinis.
5. one of according to claim 1-2 described Chinese medicine compositions for deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome, is characterized in that described Chinese medicine composition also comprises one or more of Rhizoma Pinelliae Preparata, Pericarpium Citri Reticulatae, Pericarpium Trichosanthis and Bulbus Allii Macrostemonis.
6. one of according to claim 1-2 described Chinese medicine compositions for deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome, is characterized in that described Chinese medicine composition also comprises one or more of Semen Ziziphi Spinosae, Semen Platycladi, Magnetitum, Concha Haliotidis, Cortex Albiziae and Caulis Polygoni Multiflori.
7. one of according to claim 1-2 described Chinese medicine compositions for deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome, is characterized in that described Chinese medicine composition also comprises one or more of Pericarpium Citri Reticulatae Viride, Radix Bupleuri, Cortex Moutan and Semen Vaccariae.
8. one of according to claim 1-2 described Chinese medicine compositions for deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome, is characterized in that described Chinese medicine composition also comprises one or more of Pollen Typhae, Herba Taraxaci, Rhizoma Curcumae, Herba Patriniae, Herba Violae, Radix Sophorae Tonkinensis, Flos Lonicerae, Fructus Forsythiae, Herba Commelinae, Rhizoma Osmundae, Rhizoma Paridis, Rhizoma Smilacis Glabrae and Rhizoma Paridis.
9. one of according to claim 1-2 described Chinese medicine compositions for deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome, is characterized in that described Chinese medicine composition also comprises one or more of Hirudo, Rhizoma Curcumae, Olibanum, Myrrha, Eupolyphaga seu steleophaga, Pollen Typhae, Semen Persicae, rhizoma sparganic, Scolopendra and Pheretima.
10. one of according to claim 1-2 described Chinese medicine compositions for deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome, is characterized in that described Chinese medicine composition also comprises one or more of Concha Ostreae, Fructus Tritici Levis and Radix Ephedrae.
11. one of according to claim 1-2 described Chinese medicine compositions for deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome is characterized in that described Chinese medicine composition also comprises one or more of Fructus Evodiae, Radix Aucklandiae (Radix Vladimiriae) and Fructus Amomi.
12. one of according to claim 1-2 described Chinese medicine compositions for deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome is characterized in that described Chinese medicine composition also comprises Semen Persicae.
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| CN1861166A (en) * | 2005-05-11 | 2006-11-15 | 绿谷（集团）有限公司 | Medicinal composition for treating hyperinsulinar type polycystic overies and its prepn. method |
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| Title |
|---|
| .《中医药治疗多囊卵巢综合征研究概况》.《河南中医》.1994,第14卷(第2期),123－125. * |
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