CN104524422A

CN104524422A - Pill for treating gynecomastia and preparation method thereof

Info

Publication number: CN104524422A
Application number: CN201410706426.9A
Authority: CN
Inventors: 牛兆霞; 杨美荣; 朱雪洁
Original assignee: Individual
Current assignee: Qingdao Women and Childrens Hospital
Priority date: 2014-11-28
Filing date: 2014-11-28
Publication date: 2015-04-22
Anticipated expiration: 2034-11-28
Also published as: CN104524422B

Abstract

The invention discloses a pill for treating gynecomastia and a preparation method thereof, and belongs to the field of traditional Chinese medicine. The pill comprises the raw materials of effective components: eucommia bark, radix dipsaci, semen cuscutae, white atractylodes rhizome, herba epimedii, fructus lycii, cortex cinnamomi, radix bupleuri, nutgrass galingale rhizome, pericarpium citri reticulatae, radix salviae miltiorrhizae, poria cocos, cortex moutan, rhizoma chuanxiong, radix paeoniae rubra, radix polygoni multiflori, rhizoma curcumae, cornua cervi pantotrichum, radix cyathulae, rhizoma alismatis, rhizoma pinellinae praeparata, tuber fleeceflower stem, bulbus fritillariae cirrhosae, licorice, pulp of cornus, and curculigo orchioides; the above medicines are processed in a certain way to prepare the pill product. The selected medicines meet the principle of different raw materials having different functions, drug properties are adapted and complemented with each other, the remedy is suited to the cases aiming at loss of nourishment of liver and kidney, blood and qi stagnation, liver qi depression and phlegm stasis, qi stagnation and blood stasis and other pathogenesis, and the pill has the effects of nourishing the liver and kidney, smoothing liver and resolving depression, and promoting blood circulation to remove meridian obstruction, has the advantages of good absorption effect, obvious curative effect, no toxic or side effect and no clinical adverse reactions, and has relatively high cure rate on gynecomastia through clinical verification.

Description

A kind of pill and preparation method for the treatment of gynecomastia

Art

The present invention relates to the field of Chinese medicines, particularly relate to a kind of pill and preparation method for the treatment of gynecomastia.

Background technology

Gynecomastia is common clinical disease, refers to that man's breast is in adolescence or one-sided or bilateral breast increase after growing up, and occurs oblate lump under mammary areola, even present gynecoid type breast, with the disease of distending pain.Clinical in gynecomastia.Primary disease can betide adolescence and grow up after, but with middle age and the aged be many.Along with the hebetic age shifts to an earlier date, the clinical child patient also seeing about 10 years old.Primary disease belongs to optimum mammary gland interstitial and ductal hyperplasia, and has the case disappeared voluntarily.

Modern medicine thinks that the pathogenic factor of primary disease is not still affirmed, it is generally acknowledged relevant with endocrine disturbance.The inflammation of testicular hypoplasia or testis, damage, tumor can cause androgen secretion to reduce.And the exception of liver function, can cause again estrogenic deactivation generation obstacle, both all can make the estrogen level in body relatively increase, thus cause mammary gland tissue to be grown and paraplasm.In addition, the long-term taking estrin treatment because of prostate hyperplasia and carcinoma of prostate, and the medicine such as prolonged application Folium Digitalis Purpureae, reserpine, isoniazid, ftivazide, all can cause male breast to breed loose.

Western medical treatment there are at present Drug therapy and the operative treatment of adjustment estrogen and androgen level.Operation is generally carried out under local anaesthesia, and general operation has through areola edge, nipple, mammary areola transverse incision and make " L " shape otch outside mammary areola and breast, by mammary gland tissue and partial skin excision.Postoperative drainage, pressure dressing, takes 7 days antibiotic prophylaxis and infects; The hormone medicine treatments such as heptanesulfonic acid dihydrotestosterone, tamoxifen, clomifene, testosterone lactone also can be used except operation.But abnormal pigmentary deposit on the skin trace is easily stayed for surgical removal, not only affects attractive in appearance but also easily recur.How not adopt at present, remove because breast is excessive, distending pain is obvious, even causes patient mental upper anxious; And long-term steroid adjustment class Drug therapy, can not short-term response, need Long-term Hormone medicine, this can have very large side effect to patient, therefore the Therapeutic Method of doctor trained in Western medicine to gynecomastia is unsatisfactory.

The traditional Chinese medical science is thought, man's breast belongs to kidney, nipple belongs to liver, if feelings will is uncomfortable, rage impairing the liver, cause depression of liver-QI not smooth, strongly fragrant then fire-transformation of a specified duration, to burn the body fluid of Liver and kidney, liver function injury, function of detoxification is low, the estrogen making human body too much can not be able to deactivation at liver, and act on target organ breast, or aged debility, the kidney usually involved in chronic disease, caused by liver and kidney deficiency, the deficiency of both YIN and YANG of kidney, edema with the liver involved can not be conserved, wood gas does not relax, catharsis is neglected one's duty, then phlegm-damp stops gathering, also this disease can be there is in the newborn network of upper knot, or congenital pathogen impairing the liver, it is foster that the liver failing to maintain the normal flow of QI all can cause meridians to lose, QI and blood is not smooth, thus there is blood stasis and phlegm stagnation, obstruction of meridian forms gynecomastia.In a word, this sick position, at breast, dialectically relates to liver,spleen,kidney; Characteristic of disease simulataneous insufficiency and excessive; Leading pathogenesis is liver energy depression and phlegm stagnation, qi depression to blood stasis; Treat also soothing the liverly to reduce phlegm, promoting flow of QI and blood, help with hard masses softening and resolving, kidney tonifying, essence replenishing etc.; Add and subtract with disease time clinical.The one-tenth side of current Chinese traditional treatment gynecomastia is less, and greatly mainly with depressed liver-energy dispersing and QI regulating, dredge the meridian passage is main, has certain curative effect, but treatment cycle longer take effect slow.

Pill many employings adjusting and reinforcing liver and kidney of the present invention, with---hypophysis---function between testis axis that regulates hypothalamus, recovers liver function simultaneously, strengthen the estrogenic deactivation of surplus, enhance metabolism, improve qi-blood circulating, reach and protect the liver kidney tonifying, reasonable adjusting endocrine, makes hormone in vivo level keep relative equilibrium, for treatment gynecomastia, from old complaint, treating both the principal and secondary aspects of a disease, without the side effect of doctor trained in Western medicine hormone medicine, curative effect is also very remarkable.

Summary of the invention

The invention provides a kind of pill and preparation method for the treatment of gynecomastia, there is nourishing the liver and kidney, soothing liver-QI for relieving depression, effect of dissipating phlegm and resolving masses, cure the disease and ask source treating both the principal and secondary aspects of a disease, to the gynecomastia that a variety of causes causes, all there is good curative effect.

For achieving the above object, technical scheme of the present invention is implemented as follows:

Treat a pill for gynecomastia, raw material composition and the parts by weight of making described effective ingredient are:

Raw material composition and the parts by weight of making described effective ingredient are:

Treat a preparation method for the pill of gynecomastia, comprise following processing step:

(1) Fructus Lycii, Fructus Corni, Cortex Cinnamomi, Poria, Cortex Moutan, Radix Bupleuri, Pericarpium Citri Reticulatae, Radix Cyathulae, Rhizoma Pinelliae Preparatum, Caulis Polygoni Multiflori, Radix Glycyrrhizae are cleaned, dry rear mix homogeneously, put into container, add the water of 6 ~ 8 times amount in a reservoir, heated and boiled 3 ~ 4 hours, gets immersion after cooling; The water of 4 ~ 6 times amount is added again, heated and boiled 2 ~ 3 hours, immersion after cooling in remaining medicinal residues; Merge twice gained immersion, heating, evaporation and concentration is the thick paste of relative density 1.10 ~ 1.20, for subsequent use;

(2) Radix Polygoni Multiflori, Radix Dipsaci, Semen Cuscutae are put into container, add the shao-hsing rice wine of 3 ~ 5 times amount, cool after boiling, continue immersion 3 ~ 4 hours, get immersion; In remaining medicinal residues, add the shao-hsing rice wine of 2 ~ 3 times amount again, put after boiling and dry in the air, continue immersion 2 ~ 3 hours, get immersion; Merge twice gained immersion, add and steam the thick paste that evaporation and concentration is relative density 1.15 ~ 1.25, for subsequent use;

(3) Cornu Cervi Pantotrichum, Rhizoma Curcumae, Bulbus Fritillariae Cirrhosae are ground into powder after pulverizing, cross 120 order dusting covers, obtain fine powder, for subsequent use;

(4) Rhizoma Atractylodis Macrocephalae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Rhizoma Curculiginis are put into iron pan, the micro-stir-fry of slow fire, fry after turning yellow to epidermis, spray Ji Me Lao Jiu, after continuation stir-fry is sallow to epidermis, taking-up cools, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(5) get Rhizoma Cyperi and clean section, add quantitative rice vinegar and mix thoroughly, after moistening to vinegar is sucked, puts in parch container, heat fried dry with slow fire, taking-up is dried in the air cool.Sieve removes chip, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(6) getting quantitative common salt is dissolved in clear water, evenly admixes in Eucommia ulmoides, and put heating in pot and stir-fry to dry, medical material surface color is degree slightly deeply, and sieve removes chip, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(7) get Adeps caprae seu ovis and enter heat fused in pot, then add Herba Epimedii mix thoroughly stir-fry to Adeps caprae seu ovis exhaust, medical material is crisp, sieve remove chip, pulverizing is ground into powder, cross 120 order dusting covers, obtain fine powder, for subsequent use;

(8) get Radix Salviae Miltiorrhizae, Rhizoma Alismatis is cleaned section and dries, add Radix Salviae Miltiorrhizae, Rhizoma Alismatis sheet, stir-fry for several times, even with yellow wine spray, fried dry, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(9) thick paste of just step (1), step (2) gained, mix with the fine powder of gained in step (3), step (4), step (5), step (6), step (7), step (8), add after refined honey stirs, be prepared as the pill of every 10g.

The property of medicine of the present invention's Chinese medicine used is as follows:

The Cortex Eucommiae: sweet in the mouth; Micro-pungent; Warm in nature.Enter liver; Kidney channel.Invigorating the liver and kidney; Bone and muscle strengthening.Cure mainly spinal column ache; Rheumatic arthralgia.Prescriptions Worth Thousand Gold for Emergencies carries: " liver and kidney tonifying, fills blood for wind-damp dispelling, stopping numbness pain, and be affected by the cold damp, chills and pain of the waist and kness, podomere joint stuffiness, or benumbs meciless, fear of cold happiness temperature." modern medicine study confirms, the Cortex Eucommiae has sedation to nerve centre, can strengthen the immunologic function of cell, promotes cortisol secretion and cAMP in plasma and cGMP metabolism.

Radix Dipsaci: bitter in the mouth; Pungent; Slightly warm in nature.Return liver; Kidney channel.Invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Continuous injured; Only metrorrhagia.For back ache; Podomere flaccidity syndrome and arthralgia syndrome; Fall and flutter wound; Damage dish folding bone; Carbuncle skin ulcer swells." Standards of Diagnosis and Treatment " carry: " sweet temperature is supporing yang, pungent with dissipating blood stasis, has liver and kidney tonifying concurrently, strong bone strengthening, the merit of promoting blood circulation." modern medicine study confirmation, Radix Dipsaci contains multiple alkaloid and Trace Element Titanium, has the effect of vitamin antagonist E deficiency disease, carbuncle and ulcer is had to the effect of evacuation of pus, hemostasis, analgesia, promotion tissue regeneration.

Semen Cuscutae: acrid in the mouth; Sweet; Property is put down.Enter liver; Kidney; Spleen channel.The kidney invigorating and essence nourishing; Nourishing the liver to improve visual acuity; Gu tire stopping leak.Cure mainly soreness of waist and knee joint; Seminal emission; Sexual impotence; Premature ejaculation; Sterile; Quench one's thirst; Stranguria with turbid discharge; The enuresis; Blurred vision tinnitus; Frequent fetal movement; Miscarriage; Have loose bowels." book on Chinese herbal medicine converge with speech " carries: " the kidney invigorating nourishing the liver, warming the spleen helps the medicine of stomach also, but mends and not high, temperature and not dry, and void can be mended, in fact can be in order to, cold can temperature, heat can be cool, and temperature can be dry, dryly can moisten." modern medicine study confirms, Semen Cuscutae can protect hepatic injury active significantly, increases nonspecific resistance, enhancement vigor, also has antitumor, antiinflammatory, antisterility, diarrhea inducing in addition and suppresses the effect of central nervous system.

The Rhizoma Atractylodis Macrocephalae: bitter in the mouth; Sweet; Warm in nature.Return spleen; Stomach warp.Invigorating the spleen and benefiting QI; Dampness diuretic; Hidroschesis; Antiabortive.Cure mainly deficiency-weakness of spleen-QI; Spiritlessness and weakness; Lack of appetite abdominal distention; Large loose stool is thin; Fluid-retention stagnating in the interior; Dysuria; Edema; Dizziness due to fluid-retention; Arthralgia chiefly caused by damp pathogen is ached; Spontaneous sweating due to deficiency of QI; Frequent fetal movement." herbal classic is met former " carries: " art, raw with there being dehumidifying benefit dry, expectorant diuretic, controls anemofrigid-damp arthralgia, dead flesh convulsion subcutaneous ulcer, blood between loose waist umbilicus, and chong channel is disease, the merit of inverse gas pain in the abdomen; Make ripe, have and middle QI invigorating, slake thirst and help produce saliva, hidroschesis heat extraction, enters diet, antiabortive effect." modern medicine study confirmation, the Rhizoma Atractylodis Macrocephalae has effect that is strong and raising body resistance against diseases, strengthen the phagocytic function of reticuloendothelial system, strengthen the function of leukocytes phagocytic staphylococcus aureus, leukogenic effect is had to leukopenia, improve lymhocyte transformation rate, promote cellular immune function, to staphylococcus aureus, Hemolytic streptococcus, viridans streptococci, streptococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus subtilis has inhibitory action in various degree, to acrothesium floccosum, star-shaped nocardia, trichophyton, the dermatophytess such as Trichophyton concentricunm have certain inhibitory action.

Herba Epimedii: acrid in the mouth; Sweet; Warm in nature.Enter liver; Kidney two warp.Kidney invigorating and YANG supporting; Expelling wind and removing dampness; Strengthening the tendons and bones.Cure mainly soreness of the waist and knees; Rheumatic arthralgia; Hemiplegia; Extremity are meciless." Bencao Jingshu " carries: " kidney tonifying liver then muscles and bones is certainly hard for liver governing tendons, kidney governing bones.Pungent can eliminating stagnation, in Gan Nenghuan, temperature can be ventilated promoting the circulation of blood, therefore the red carbuncle of main scrofula, and skin ulcer is arranged at bottom, washes out worm." modern medicine study confirmation; Herba Epimedii has more significant inhibitory action to Staphylococcus albus, staphylococcus aureus; have slight inhibitory action to Nai Shi micrococcus catarrhalis, Diplococcus pneumoniae, hemophilus influenza; can reduce red blood cell hematocrit; accelerate erythrocyte sedimentation rate; reduce whole blood contrast viscosity, improves DNA synthetic ratio.

Fructus Lycii: sweet in the mouth; Property is put down.Return liver; Kidney; Lung meridian.Nourishing the liver; Nourishing kidney; Lung moistening.Cure mainly caused by liver and kidney deficiency; Have a dizzy spell; Visual one clear; Soreness of the waist and knees; The expensive essence of sexual impotence; Cough due to consumptive disease; To quench one's thirst taking fluids profusely." book on Chinese herbal medicine just " carries: " improve visual and auditory acuity, adds the solid marrow of essence, strengthen the muscle and bone, and kind benefit impairment caused by overstrain, especially only quenches one's thirst." modern medicine study confirm, Fructus Lycii scalable body's immunity, can effectively Tumor suppression grow and cell mutation, there is the effect of the aspect such as slow down aging, anti-fatty liver, adjusting blood lipid and blood glucose, promotion hemopoietic function.

Cortex Cinnamomi: acrid in the mouth; Bitter; Hot in nature.Enter kidney; Spleen; The heart; Liver Channel.Mend fire supporing yang; Let the fire back to its origin; Dispersing cold for relieving pain; Warming the meridian and promoting blood circulation.Cure mainly insufficiency of kidney-YANG; Gate of vitality's fire; Aversion to cold and cold limbs; Soreness of the waist and knees; Impotence and seminal emission; Dysuria or frequency; To lose heart dyspnea with rapid and short breath; The all cards of edema oliguria; Decline of the fire from the gate of life; Fire is Gui Yuan not; Floating YANG; Refusing yang; And heat in the upper and cold in the lower; Flushed complexion cold foot; Dizziness and tinnitus; Dispute gruel is broken; Spleen-kidney vacuity cold; Coldness and pain in the epigastrium; Decreased food intake loose stool; Lumbago due to renal deficiency; Arthralgia due to cold-dampnes; Colic of cold type pain; Cold womb is infertile; Dysmenorrhea amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Carbuncle of yin nature multiple abscess; Or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus; Or do not hold back after bursting." property of medicine opinion " carries: " cure mainly nine types of precordial pain, kill three worms, main removing blood stasis, the tonneau moon closes, and controls weak foot, numbness, meciless, retention of placenta, and except cough with dyspnea, stagnation of QI, gather around numbness, only cold air in abdomen, unbearably painful, main dysentery, nasal polyp.Herbicide wood poison." modern medicine study confirmation, Cortex Cinnamomi contains the compositions such as cinnamic aldehyde, cinnamyl acetate, acetoxyphenyl group third cheese, has the effect of fragrant stomach invigorating, antipyretic-antalgic, anti-inflammation.

Radix Bupleuri: bitter in the mouth; Pungent; Cold nature.Return liver; Gallbladder meridian.Induce sweat and bring down a fever; Dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Cure mainly: fever caused by exogenous pathogens; Alternate attack of chill and fever; Malaria; Hypochondriac pain due to stagnation of liverQI mammary swelling; Headache dizziness; Menoxenia; The proctoptosis of collapse of QI; Uterine prolapse; Gastroptosis." detailed outline " carries, and " control yang-energy to sink, suppressing the hyperactive liver, gallbladder, three burnt, envelope is mutually fiery, and headache, dizzy, and blurred vision, swelling pain are hidden from view, deaf ring, all malarias, and lump at the left hypochondrium cold and heat, married woman's invasion of the blood-chamber by heat, irregular menstruation, children's's varioliform exanthema waste heat, the thin heat of five kinds of child malnutrition." modern medicine study confirms, Radix Bupleuri has antipyretic, calm, analgesia, antitussive, antiinflammatory action, resists hepatic injury, function of gallbladder promoting, anti-fatty liver simultaneously, and promotion enterokinesia etc. has certain effect.

Rhizoma Cyperi: acrid in the mouth; Cold nature; Nontoxic.Return liver; Lung; Spleen; Stomach; Tri-jiao channel.To regulate the flow of vital energy resolving depression; Menstruction regulating and pain relieving; Antiabortive.Cure mainly distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation; Vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement." detailed outline " carries: " loose seasonal epidemic pathogens is trembled with fear epidemic disease, and profit three is burnt, Xie Nvyu, and the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot; abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, and ulcer sores is spitted blood; hematochezia, hematuria, married woman's bleeding not during menses, menoxenia, before tire puerperal all kinds of diseases and ailments." modern medicine study proves, Rhizoma Cyperi energy nervous system regulation function, has heart tonifying, decreased heart rate, reduces blood pressure, prevents and treats the effect such as hyperlipemia and atherosclerosis.

Pericarpium Citri Reticulatae: acrid in the mouth; Sweet; Cold in nature.Enter spleen; Stomach warp.The therapeutic method to keep the adverse QI flowing downwards; In tune; Reduce phlegm; Relieving alcoholic intoxication.Cure mainly drinking and eating irregularly; Upper gas stuffy sensation with restlessness; Get sick from drinking too much wine thirsty." Japan hanako materia medica " carries: " skin is processed and is made soup, can alcoholic intoxication and wine thirsty, typhoid fever diet recurrence caused by overexertion person, densely decocts juice clothes." medicine clinical research shows; the Hesperidin contained by Pericarpium Citri Reticulatae can suppress gastric ulcer; reduce capillary permeability; have adjustment gastrointestinal function and antiinflammatory action; its volatile oil has eliminating the phlegm, relievings asthma, facilitating digestion liquid secretion and get rid of the effects such as enteral pneumatosis, also has coronary artery dilator in addition, reduces blood pressure and the effect such as function of gallbladder promoting.

Radix Salviae Miltiorrhizae: bitter in the mouth; Cold nature; Nontoxic.Enter the heart; Liver Channel.Promoting blood flow to regulate menstruation; Stasis-dispelling and pain-killing; Removing heat from blood eliminating carbuncle; Clear away heart-fire relieving restlessness; Nourishing blood to tranquillize the mind.Cure mainly trusted subordinate's pathogen; Cold and heat gather; Ailment said due to cold or exposure stays heat." herbal classic " carries: " main trusted subordinate's pathogen, borborygmus are faint as leaked water, and cold and heat gather; Broken disease, except abdominal mass, stops stuffy sensation with restlessness, QI invigorating." modern medicine study confirms; Radix Salviae Miltiorrhizae can improve plasmin activity; extend hemorrhage, clotting time; anticoagulant; coronary artery dilating and peripheral blood vessel, increases myocardial flow, promotes reparation and the regeneration of tissue; promote fibroblast differentiation and the formation of collagen fiber, the synthesis of originality cholesterol in T suppression cell

Poria: sweet in the mouth; Light; Property is put down.Enter the heart; Spleen; Lung; Kidney channel.Eliminating dampness and diuresis; Invigorating the spleen and regulating the stomach; Mind tranquilizing and the heart calming.Cure mainly dysuria; Edema distension; Phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Let out wash with watercolours; Palpitation and restlessness; Insomnia forgetfulness; Seminal emission nebulousurine." not Lu " carries: " only quench one's thirst, like to sleep, large abdomen, drench drop, the disease due to obstruction of QI of middle-JIAO expectorant water, edema drenches knot.Open breast internal organs, adjust visceral-qi, cut down kidney heresy, long cloudy, physical strength profiting, during guarantor god keeps." modern medicine study confirmation; Poria all has inhibitory action to staphylococcus aureus, escherichia coli, Bacillus proteus etc.; can kill the antibacterials such as leptospira; have certain protective effect to digestive system, blood system and central nervous system; pachyman content is very high in addition, can anti-tumor activity.

Cortex Moutan: acrid in the mouth is bitter; Cool in nature, be slightly cold, GUIXIN; Liver; Kidney; Lung meridian.Heat clearing away; Promoting blood circulation to remove blood stasis.Cure mainly: the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The pathogenic bacteria later stage brimful of tears, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and flutter the pain of injury; Beriberoid pyretic arthralgia.Compendium of Material Medica: Cortex Moutan, controls the few the moon of brothers, faints cloudy four through blood system volt fire.Gai Fuhuo and YIN-fire also, YIN-fire namely mutually fire also, ancient prescription only controls fire mutually with this, therefore Zhong Jing shenqi pill uses it.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of Cortex Moutan more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it.

Rhizoma Chuanxiong: acrid in the mouth; Warm in nature.Return liver; Gallbladder; Pericardium channel.Blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping.Zhu Zhi WEIJIA lump; Pain in chest and hypochondrium; Have a headache dizzy; Anemofrigid-damp arthralgia; Traumatic injury; Ulcer sores." book on Chinese herbal medicine just " carries: " dispersing wind and cold, control pain, removing blood stasis with potent drugs stores, promoting blood circulation, separates stagnation of QI, and by pain, evacuation of pus is subsided a swelling, and stimulates the menstrual flow by blood." modern medicine scientific research discovery; Rhizoma Chuanxiong extracting solution has certain effect to suppression leukaemia; preparation has certain antibacterial action; especially all have inhibitory action to Bacillus typhi, Salmonella paratyphi, vibrio cholera, bacillus pyocyaneus and pathogenic dermatophytes etc.; the ligustrazine contained by Rhizoma Chuanxiong, ferulic acid are received has blood circulation invigorating efficacies; expansible coronary artery, promote coronary flow, allevating angina pectoris, and there is anti-thrombosis function, contained cnidium lactone has smooth muscle spasmolysis and suppresses the effect such as myenteron, uterine contraction.

Radix Paeoniae Rubra: bitter in the mouth; Be slightly cold.Return Liver Channel.Clearing away heat and cooling blood; Eliminating stasis to stop pain.Cure mainly maculae caused by violent heat pathogen, hematemesis and epistaxis; Conjunctival congestion and swelling pain; Hypochondriac pain due to stagnation of liverQI; Amenorrhea dysmenorrhea; Lump in the abdomen is suffered from abdominal pain; Injury from falling down; Carbuncle skin infection.Shennong's Herbal carries: " bitter in the mouth is put down, main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending cold and heat hernia abdominal mass, pain relieving, and raw Semen Coicis." modern medicine study confirms; Radix Paeoniae Rubra changes to the viscid blood patients with coronary heart disease of height the effect of hemorheological property; can make whole blood viscosity when erythrocyte electrophoretic time reduce; by affect calcium metabolism antagonism atherosclerosis; water-alcohol extraction has significant sedation and analgesic effect; slightly can improve the acidity of gastric juice, can be used for improvement appetite, digestive function and some neuropathy.

Radix Polygoni Multiflori: bitter in the mouth; Sweet; Puckery; Slightly warm in nature.Return liver; Kidney channel.Nourishing the blood and yin; Loosening bowel to relieve constipation; Preventing the attack (or recurrence) of malaria; Dispel the wind; Removing toxic substances.Cure mainly: blood deficiency Light-headedness; Cardiopalmus; Insomnia; The soreness of the waist and knees of the hepatic and renal YIN deficiency; Early whitening of beard and hair; Tinnitus; Seminal emission; Dryness of the intestine constipation; Chronic malaria body is empty; Rubella pruritus; Carbuncle sore; Scrofula.Compendium of Material Medica: Radix Polygoni Multiflori, white person enters edema caused by disorder of QI, and red person enters blood system.Kidney master closes Tibetan, liver controlling conveyance and dispersion, this thing temperature bitter and puckery flavor, bitter the kidney invigorating, and temperature compensation liver, can restrain vital essence, so the liver benefiting that can nourish blood, controlling nocturnal emission with astringent drugs kidney tonifying, muscle reinforcing and bone strengthening, black hair is tonic medicine, and cold not dry, merit is on Radix Rehmanniae, all medicines of Radix Asparagi.QI and blood Taihe county, then wind void, carbuncle, all diseases of scrofula known (removing).

Rhizoma Curcumae: acrid in the mouth; Bitter; Warm in nature.Return liver; Spleen channel.Circulation of qi promoting removing blood stasis; Removing food stagnancy pain relieving.Cure mainly vim and vigour pained; Eating accumulation; Abdominal distention; Amenorrhea due to stagnation of blood; Dysmenorrhea; WEIJIA tumor mass in the abdomen; Traumatic injury." medicineization justice " carries: " acrid in the mouth is strong, specializes in the blood in gas, and main removing mass disappears heavily fortified point, goes to gather addiction block, amenorrhea blood stasis, flutters report pain." modern medicine study confirmation; the growth of Rhizoma Curcumae to multiple tumor strain has significantly suppression and destruction; have inhibitory action to tumor, the metabolism of cancerous cell core; significantly improve the content of lymphocytes in blood; strengthen oncocyte immunogenicity; temptation or promotion body, to the immunological rejection of tumor, improve the effect of radiation therapy.Take orally and decoct soup, grind into powder or enter ball and fall apart; External is decocted soup and is washed or grind into powder and dress.The how raw use of promoting the circulation of QI to relieve pain, removing blood stasis should be fried by vinegar.

Cornu Cervi Pantotrichum: sweet in the mouth; Salty; Warm in nature.Enter kidney; Liver Channel.Invigorating kidney-YANG; Benefiting essence-blood; Bone and muscle strengthening; Holder sore.Cure mainly kidney yang deficiency; Sexual impotence spermatorrhea; Cold womb is infertile; Asthenia is won thin; Mental fatigue fear of cold; Dizzy; Hiccough and deaf; Aching pain in waist and back; Muscles and bones flaccidity is soft; Children's's five kinds of growth retardation; Woman's bleeding not during menses; Carbuncle of yin nature." Bencao Jingshu " carries: " treat the voluminous symptoms like malaria of asthenia, weakness and emaciation, painful limbs, pain along the spinal column, normal urination, lets out essence, hematuria, and broken stagnant blood is at abdomen, and loose stranguria caused by urinary stone, carbuncle, heat in bone, cellulitis is itched." modern medicine study confirm; Cornu Cervi Pantotrichum contains abundant aminoacid, lecithin, vitamin and trace element; can improve cellular immunization and the humoral immune function of body; promote lymphocytic conversion; have the effect of immunopotentiating agent; can also increase body defence capability to external world, the immunologic balance in control agent and avoid disease occur and promote wound healing, sick body rehabilitation.

Radix Cyathulae: sweet in the mouth; Micro-hardship; Property is put down.Enter liver; Kidney channel.Blood circulation promoting and blood stasis dispelling; Expelling wind and removing dampness.Cure mainly blood stasis amenorrhea; Difficult labour; Retention of placenta; Postnatal blood stasis is suffered from abdominal pain; Pyretic stranguria; Stranguria caused by urinary stone; Dysmenorrhea; Rheumatism lumbocrural pain." Traditional Chinese Medicine in Sichuan will " carries: " expelling wind and removing dampness, stimulate the menstrual flow loose blood, controls gonorrhea, hematuria, loses and drown." modern medicine study confirmation, the insectean metamorphosis steroidal contained by Radix Cyathulae has stronger protein synthesis facilitation.

Rhizoma Alismatis: sweet in the mouth; Light; Cold in nature.Return kidney; Urinary bladder channel.Promoting diuresis to eliminate damp pathogen; Expel the heat-evil treating stranguria.Cure mainly dysuria; The puckery pain of pyretic stranguria; Edema distension; Have loose bowels; Dizziness due to fluid-retention; Seminal emission." not Lu " carries: " tonifying deficiency five kinds of over strain, except the five internal organs feeling of fullness, plays cloudy gas, stopping leak essence, quenches one's thirst, drenches drop, cuts off the water by bladder, three Jiao." modern medicine study confirmation, Rhizoma Alismatis has reduction cholesterol and atherosclerosis effect, improves liver lipid metabolism, reduces blood glucose, blood pressure, affects function of immune system, reduces serum hemolysin.

Rhizoma Pinelliae Preparatum: acrid in the mouth; Warm in nature; Be slightly cold.Enter spleen; Stomach warp.Drying dampness to eliminate phlegm; Sending down the abnormal ascending QI preventing or arresting vomitting; Dissolving lump and resolving mass; Outer subduing inflammation." not Lu " carries: " subduing inflammation, treats sallow, happy damp appearance." modern medicine study confirmation, the Rhizoma Pinelliae has significant antitussive effect, can suppress the secretion of body of gland, suppresses tryptic hydrolysis, also has blood pressure lowering, blood coagulation, the fissional effect of promotion in addition.

Caulis Polygoni Multiflori: sweet in the mouth; Micro-hardship; Property is put down.Enter the heart; Liver Channel.Tranquilizing by nourishing the heart; Dispel the wind; Dredging collateral.Cure mainly insomnia; Dreaminess; Blood deficiency general pain; Numbness of the skin; Rheumatic arthralgia; Rubella pruritus." decoction pieces is newly joined " carries: " nourishing the liver and kidney, only sweating due to debility, hypnosis of calming the nerves, invigorating middle warmer gas, network of passing through, promoting blood circulation, controls impairment caused by overstrain." modern medicine study confirmation, Caulis Polygoni Multiflori contains emodin, physcione, is synergism with pentobarbital sodium, has significant calmness, syngignoscism, especially extends S sleep phase.

Bulbus Fritillariae Cirrhosae: sweet in the mouth; Bitter; Cold nature.Return lung; Heart channel.Clearing heat and moistening lung; Preventing phlegm from forming and stopping coughing; Mass dissipating and swelling eliminating.Cure mainly the deficiency of the lung; Chronic cough; Cough due to consumptive disease; Cough caused by dryness-heat; Lung abscess; Scrofula; Carbuncle; Acute mastitis." book on Chinese herbal medicine converge with speech ": Bulbus Fritillariae Uninbracteatae, dissipating depression of QI, the therapeutic method to keep the adverse QI flowing downwards, the medicine that reduces phlegm are also.Lung moistening expectorant, relieving cough and relieving asthma, the then card of asthenia fire knot, Bulbus Fritillariae Uninbracteatae specially takes charge of first dose.Therefore join the Rhizoma Anemarrhenae, can clearing heat in QI system YIN nourishing; Join a kind of reed mentioned in ancient books, connecting can clearing away phlegm pathogenic fire reducing; Join to join over sixty years of age can go to mend and do not gather; Join return, Chinese herbaceous peony can regulating QI and battalion; Stick up can resolving depression poison for accessory again, controls wart core under item; Join two old generation half summer grade, can tonifying the lung expectorant and middle pathogenic fire reducing person also.More than repairing use, must be wonderful with river person.If separate carbuncle poison, broken crux, disappear real expectorant, applies malignant boil, is good again with native person.The lightly seasoned property of right river person is excellent, and native person's bitter in the mouth is bad, and the two is to use respectively.Modern medicine study confirms, Bulbus Fritillariae Cirrhosae has significant antitussive and phlegm-dispelling functions, significantly suppresses pepsin and stress ulcer, suppresses central nervous system.

Radix Glycyrrhizae: sweet in the mouth; Property is put down.GUIXIN; Lung; Spleen; Stomach warp.Invigorating the spleen and replenishing QI; Heat-clearing and toxic substances removing; Expelling phlegm for arresting cough; Relieving spasm to stop pain; Coordinating the actions of various ingredients in a prescription.Cure mainly weakness of the spleen and stomach; Fatigue and weakness; Shortness of breath and palpitation; Cough with copious phlegm; Gastral cavity abdomen four muscle spasm of the leg and foot pain; Carbuncle sore tumefacting virus; Cushion toxicity.Compendium of Material Medica is carried: " in all medicines, Radix Glycyrrhizae is monarch.Control 72 kinds of mammary calculus poison, draft is malicious by every means to separate 1,002, is in harmonious proportion from medicine and gains merit." modern medicine study confirmation; Radix Glycyrrhizae has stronger Detoxication; also have antiulcer, anti-inflammatory, spasmolytic antitussive, blood pressure lowering, blood fat reducing, antitumaous effect; be widely used in the diseases such as treatment pharyngolaryngitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis, have anti-gastric-ulcer, gastritis effect in addition.

Fructus Corni: sour in the mouth; Slightly warm in nature, returns liver; Kidney channel.Liver and kidney tonifying; Convergence is solid de-, cures mainly: waist is had a dizzy spell; Deafness and tinnitus; Soreness of the waist and knees; Xian essence spermatorrhea; Frequent micturition; Incessant sweating due to debility; Woman uterine bleeding." Elementary Medicine ": this astringent of Fructus Corni also, how can lead to and send out heresy? covering all diseases is all bottom deficiency and coldness, the tonic Liver and kidney of use, and with Yi Qiyuan, then the five internal organs Amway, only, the meaning of the light dredging of Fei Ruota medicine also for the logical and sharp person of the person of closing.Modern medicine study shows: Fructus Corni has antibacterial, immunity moderation, blood sugar lowering, blood fat reducing, antioxidation, anticancer, the function such as anti-AIDS, heart tonifying.

Rhizoma Curculiginis: acrid in the mouth; Warm in nature; Poisonous.Enter kidney; Liver Channel.The kidney warming sun is strong; Dispel cold-damp.Cure mainly sexual impotence cold sperm; Urinary incontinence; Coldness and pain in the epigastrium; Soreness of waist and knee joint; Muscles and bones is weak; Lower limb contracture; Climacteric syndrome." the SHENGCAO property of medicine standby will " carries: " nebulousurine is controlled in the kidney invigorating, pain relieving, and reason phlegm-fire, pot is carnivorous.Ten steam nine shines, and can strengthen spirit, black beard and hair." clinic study shows; Rhizoma Curculiginis can significantly improve the phagocytosis of macrophage; strengthen immunologic function; obviously extend the length of one's sleep; obviously extend the incubation period that toxin causes convulsion effect; improve the activity of Na-ATP enzyme, in addition antibacterial, antitumor, coronary artery dilating, heart tonifying, blood pressure lowering and antiinflammatory action in addition.

The present invention compared with prior art, has following beneficial effect:

The present invention selects medical material monarch, minister, a left side, makes all reasons all standby, the property of medicine is suitable mutually auxiliary mutually, Liver and kidney for triggering male Gynecomastia loses supports, QI and blood is not smooth, liver energy depression and phlegm stagnation, and the causes of disease such as qi depression to blood stasis are suited the remedy to the case, and have effect of nourishing the liver and kidney, soothing liver-QI for relieving depression, promoting blood circulation to remove obstruction in the collateral, dissipating phlegm and resolving masses, good absorbing effect, evident in efficacy, have no side effect and clinical adverse, higher to gynecomastia cure rate through clinical verification.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

The raw material composition of effective ingredient of the present invention and weight are:

The processing step of process for preparing medicine of the present invention is:

(5) get Rhizoma Cyperi and clean section, add quantitative rice vinegar and mix thoroughly, after moistening to vinegar is sucked, puts parch and hold in 3 devices, heat fried dry with slow fire, taking-up is dried in the air cool.Sieve removes chip, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

Usage and dosage: oral, every day 3 each 2 balls, severe patient every day 3 each 3 balls, ante cibum

Within one hour, taking with warm water or warm yellow wine, 24 days is a course for the treatment of.

Embodiment 2

The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.

Embodiment 3

Clinical data:

1, case selection

Select the routine clinical observation of gynecomastia patient 60 that my institute or outer court make a definite diagnosis, patient is divided into two groups at random.Treatment group 30 example, male, 45 ~ 65 years old age, 56.6 years old mean age.Matched group 30 example, male, 47 ~ 64 years old age, 55.4 years old mean age.Two groups of qualifications and record of service are basically identical, without significant difference, have comparability.

2, treatment group patient takes medicine of the present invention, oral, every day 3 each 2 balls, severe patient every day 3 each 3 balls, one hour ante cibum took with warm water or warm yellow wine, within 24 days, was a course for the treatment of, took three courses for the treatment of.Matched group, according to the classification of the gynecomastia diagnosed out, is used the hormone medicine treatments such as heptanesulfonic acid dihydrotestosterone, tamoxifen, clomifene, testosterone lactone respectively.

3, efficacy determination:

(1) cure: clinical symptoms obviously disappears, palpation lump disappears, and pain disappears.

(2) take a turn for the better: clinical symptoms obviously alleviates, and palpation mass reduction, pain is obviously alleviated.

(3) invalid: before and after treatment, clinical symptoms is without obvious change.

4, result

Cure 21 examples in treatment group, take a turn for the better 7 examples, invalid 2 examples, cure rate 70%, total effective rate 93.33%.

Cure 18 examples in matched group, take a turn for the better 8 examples, invalid 4 examples, cure rate 60%, total effective rate 86.67%.

Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.

Model case is illustrated:

1, Zhao so-and-so, man, 47 years old, patient found the large and distending pain of two swelling of the breast before half a year, coming my institute haves a medical check-up medical, have a medical check-up to levy through my institute and see the obviously enlargement of two breasts, sign female breast, two breast can touch 11X11cm disk sample lump, matter is hard, the activity pushed away, smooth surface, clear border, tenderness and tenderness are obviously. be diagnosed as gynecomastia (bilateral), further consultation after taking 1 course for the treatment of of pill of the present invention, two breast obviously subsides, lump deliquescing is reduced, after serveing on two courses for the treatment of again, lump all dissipates, palpation is painless, bilateral breast recovers normal, cure.

2, Yang, man, 61 years old, the right breast of patient has lump to have distending pain sense nearly 2 years, coming my institute haves a medical check-up medical, disease is shown in right breast obvious tumefaction, the large lump of 8x7cm is touched under nipple, clear border, the activity pushed away, smooth surface, there is tenderness and sense of touching a tender spot, left newborn no abnormality seen. be diagnosed as gynecomastia (right side), after taking 1 course for the treatment of of pill of the present invention, the obvious deliquescing of lump is contracted to 5x5cm, palpation pain obviously alleviates, after serveing on two courses for the treatment of again, lump dissipates, palpation is painless, right breast shape and left side no significant difference, cure.

From clinical treatment analysis of statistical data, this disease is mainly in middle-aged and elderly people, and main cause deficiency of both the liver and kidney is this, and phlegm and qi stasis blood stasis is mark, and pill of the present invention is from old complaint, and the property of medicine is suitable mutually auxiliary mutually, is intended to the liver and the kidney tonifying, blood circulation promoting and blood stasis dispelling, this mark take into account.Chinese medicine warm invigorating the liver and kidney, the Chong and Ren Meridians regulating such as the Cortex Eucommiae, Radix Polygoni Multiflori, Herba Epimedii, Rhizoma Curculiginis, Fructus Lycii, Fructus Corni in side; The Chinese medicine such as Radix Bupleuri, Rhizoma Cyperi liver-smoothing, qi-regulating, Chinese medicine invigorating the spleen and regulating the stomach, the promoting the circulation of QI and reducing phlegm such as the Rhizoma Atractylodis Macrocephalae, Poria, Pericarpium Citri Reticulatae, Rhizoma Pinelliae Preparatum, Chinese medicine blood circulation promoting and blood stasis dispelling, the dissipating phlegm and resolving masses such as Radix Salviae Miltiorrhizae, Radix Cyathulae, Rhizoma Curcumae, Rhizoma Chuanxiong, then use Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, reach and protect the liver kidney tonifying, blood circulation promoting and blood stasis dispelling, reasonable adjusting endocrine, make hormone in vivo level keep relative equilibrium, organize 30 routine therapeutic effect from this, use pill of the present invention to treat gynecomastia, curative effect is very remarkable, and has no side effect.

Claims

1. treat a pill for gynecomastia, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:

。

2. a kind of pill for the treatment of gynecomastia according to claim 1, is characterized in that:

。

3. a kind of pill and preparation method for the treatment of gynecomastia according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:

。

4. treat a preparation method for the pill of gynecomastia, it is characterized in that: comprise following processing step: