CN1977948A - Chinese medicine composition for treating high insulin polycystic ovary syndrome - Google Patents

Abstract

The present invention relates to a Chinese medicine composition for curing female high-insulin type polycystic ovary syndrome. Said Chinese medicine composition includes 11 Chinese medicinal materials of anemarrhena root, epimedium, tortoise plastron, ophiopogon tuber, lyceum berry, polygonatum root, sea horse, flowery knotweed root and others.

Description

A kind of Chinese medicine composition for the treatment of high insulin polycystic ovary syndrome

Technical field

The invention belongs to field of traditional Chinese medicine pharmacy, relate to a kind of Chinese medicine composition for the treatment of high insulin polycystic ovary syndrome.

Background technology

(polycystic ovary syndrome PCOS) is a kind of many syndromes because of property, clinical manifestation polymorphism of falling ill that cause because of menstrual regulation mechanism is not normal to polycystic ovarian syndrome.Clinical is feature with the plain opposing in functional high island, mainly show as hypomenorrhea, amenorrhea or irregular vagina bleeding, infertile, fat, hirsutism, endometrium hyperplasia and pernicious variation, and bilateral or one-sided ovary are the change of polycystic change and some hormonal readiness etc.PCOS belongs to sick categories such as Chinese medicine is infertile, amenorrhea, metrorrhagia, disease is lame, month crust is fat.

Chinese medicine does not still have the record of this name of disease, according to clinical manifestations such as its menoxenia, infertile, amenorrheas, should belong to categories such as " amenorrhea ", " infertile ", " menoxenia ".Modern Chinese medicine is thought and is suffered from a deficiency of the kidney and two important pathogenesis of the tired POOS of being of blood.Thinking that again primary disease is tired for the blood of suffering from a deficiency of the kidney, based on insufficiency of kidney-YANG, usually is the deficiency of YIN and sun.Re-recognize for to suffer from a deficiency of the kidney.Think that in addition the expectorant of suffering from a deficiency of the kidney is its main pathogenesis in fact, and its excessive androgen, hyperinsulinemia are interior-heat caused by deficiency of YIN, dash appoint have tired.Polycystic ovarian syndrome (POOS) is the common endocrine regulation diseases of the women of child-bearing age, because its cause of disease complexity, show variously, and present clinical therapeutic efficacy is still unsatisfactory.Therefore, this disease becomes the focus and the difficult point of gynaecopathia research day by day.

Summary of the invention

Purpose in of the present invention provides a kind of Chinese medicine composition for the treatment of high insulin polycystic ovary syndrome and preparation method thereof.

The present invention is with the heat clearing away of theory of Chinese medical science kidney tonifying, and phlegm reduction of blood circulation promoting is a foundation, and with sufficient kidney yin, Yin Yang balancing changes fertile people's constitution of YIN-deficiency, dispels the consume of interior-heat to essence and blood, the blood flow smoothness, and kidney qi foot, phlegm-damp must be changed simultaneously, dash and appoint from being adjusted to principle.Adopt Chinese medicine Hippocampus 0.3-3g, Rhizoma Anemarrhenae 6-20g, Radix Ophiopogonis 6-18g, Rhizoma Polygonati 9-30g, Fructus Lycii 9-30g, Rhizoma Coptidis 3-12g, Carapax et Plastrum Testudinis 9-30g, Radix Polygoni Multiflori 9-30g, Radix Et Rhizoma Rhei 3-15g, Herba Epimedii 9-30g, Radix Angelicae Sinensis 6-20g, Spina Gleditsiae 9-30g, the Herba Verbenae 9-30g of following weight proportioning to make the Chinese medicine composition of treatment women high insulin polycystic ovary syndrome.

Described Chinese medicine composition, wherein:

Rhizoma Anemarrhenae bitter cold is gone into lung, kidney, stomach warp, nourishing kidney and clearing heat, and relieving restlessness is allayed excitement; Close the Herba Epimedii that the little hot temperature of sweet perfume (or spice) is gone into liver, kidney channel, the kidney invigorating and essence nourishing is transferred to dash and is appointed, and two medicines are our principal agent.Get the salty-cold in love product Carapax et Plastrum Testudinis of flesh and blood of going into liver, kidney channel, the marrow mind calming is mended in the YIN nourishing replenishing essence; Sweet little bitter cold is gone into the Radix Ophiopogonis of the heart, lung, stomach warp, Yin-nourishing and body fluid promoting, tired the quenching one's thirst of dispelling; Sweet Fructus Lycii of putting down into spleen, liver, kidney, lung meridian, liver and kidney tonifying, Yi Yan calms the nerves; Sweet Rhizoma Polygonati of putting down into lung, spleen, stomach warp, the spleen reinforcing lung moistening is promoted the production of body fluid and is preserved youthful looks; Gan Wen is the in love product Hippocampus of flesh and blood of impairment of YIN not, the kidney warming tonify deficiency; Close the Radix Polygoni Multiflori that bitter sweet tepor is gone into liver, kidney channel again, invigorating the liver and kidney, benefiting essence-blood is adjuvant altogether.The Rhizoma Coptidis bitter cold is gone into the heart, lung, gallbladder, stomach, the large intestine Five Classics, clears away heart-fire, the fire of lung, large intestine; The Radix Et Rhizoma Rhei processed with wine is gone into spleen, liver, large intestine channel to subtract its bitter cold, the purging FU-organs of invigorating blood circulation; The hot temperature of Spina Gleditsiae is gone into lung, large intestine channel, and the hot temperature of loosing is logical, activating blood circulation and dissipating phlegm, and the sharp power profit of property, the hot temperature of Spina Gleditsiae is gone into lung, large intestine channel, and the hot temperature of loosing is logical, activating blood circulation and dissipating phlegm, the sharp power profit of property; Close the Herba Verbenae hardship and be slightly cold into liver, spleen channel, the promoting the circulation of blood diuretic is controlled the wet resistance of married woman's stasis, the enlarged abdomen amenorrhea; Four flavors are adjuvant drug, the deficiency of the removing heat-phlegm of invigorating blood circulation that still has in the auxiliary main and auxiliary medicine enriching kidney essence.Select sweet arduous using warming therapy Radix Angelicae Sinensis, go into the heart, spleen channel promoting the circulation of bloodization and stagnate, moisturize the taste lung, be we's guiding drug.

Above-mentioned each medical material has respectively:

The Rhizoma Anemarrhenae: be the dry rhizome of liliaceous plant Rhizoma Anemarrhenae Anemarrhena asphodeloides Bge..Spring, Qiu Erji excavate, and remove fibrous root and silt, dry.Nature and flavor hardship, sweet, cold.Return lung, stomach, kidney channel.Have clearing away heat-fire, promote the production of body fluid and moisturize.Be used for fever caused by exogenous pathogenic factors, the hyperpyrexia excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, the dryness of the intestine constipation.

Studies show that in recent years, the general unit of effective ingredient Rhizoma Anemarrhenae soap (zMS) in the Rhizoma Anemarrhenae has can improve the memory of plan Model of Dementia animal learning, rising superoxide dismutase (soD) vigor, reduce lipid peroxide (LPO) and the lipofuscin (concentration of L agate, strengthen choline second phthalein transferring enzyme (chAT) activity in the brain, and can reduce intracerebral injection A β 25 1 35 rat model cerebral tissue Zou effectively and deposit pharmacological actions such as speckle.

Herba Epimedii: be the dry aerial parts of Berberidaceae plant Herba Epimedii Epimedium brevicomum Maxim., arrow leaf Herba Epimedii Epimediumsagittatum (Sieb.et Zucc.) Maxim., pubescence Herba Epimedii Epimedium pubescens Maxim., Epimedium wushanense Epimedium wushanenseT.S.Ying or Herba Epimedii Epimedium koreanum Nakai.Tap when stem and leaf is luxuriant between summer, autumn, remove thick stalk and impurity, dry or dry in the shade.Nature and flavor suffering, sweet, temperature.Return liver, kidney channel.Has kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Be used for impotence and seminal emission, the muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension disease.

Excessive sheep flower bud has another name called Herba Epimedii, and property acrid-sweet flavor, temperature are gone into Liver and kidney two warps, have kidney invigorating and YANG supporting, the strengthening the tendons and bones effect.Other has report, and the extracting solution of excessive sheep flower bud has the effect of androgen sample, and its effectiveness is better than HAHA, Hippocampus.Can also coronary blood flow increasing, lower peripheral vascular resistance, alleviate cardiac afterload, microcirculation improvement, and can resist acute myocardial ischemia damage and the experimental arrhythmia that pituitrin causes, and reduce myocardial oxygen consumption, have the effect of blood pressure lowering.Excessive sheep flower bud energy enhancing body nonspecific immunity defense function improves cytophagous phagocytic activity, and the LT effect of promotion is arranged, and drugs for nourishing yin such as the compatibility Radix Rehmanniae, mountain Fructus Corni are taken the circumstances into consideration in clinical practice, with treating YANG within YIN, are sure not to consume the moon that is impairment of the kidney.

Hippocampus: be the dry body of Syngnathidae animal strain line Hippocampus Hippocampus kelloggi Jordan etSnyder, HIPPOCAMPUS Hippocampus histrix Kaup, big Hippocampus Hippocampus kudaBleeder, hippocampus trimaculatus Leacs Hippocampus trimaculatus Leach or little Hippocampus (HAIQU) Hippocampus japonicaus Kaup.Summer, Qiu Erji catch labor, clean, and dry; Or remove epithelium and internal organs, dry.Nature and flavor are sweet, temperature.Return liver, kidney channel.Has warming the kidney to invigorate YANG, mass dissipating and swelling eliminating.Be used for sexual impotence, the enuresis is suffered from a deficiency of the kidney and is made Chuan ， WEIJIA and gather injury from falling down; External treatment carbuncle furuncle.

Modern pharmacological research confirms that the rutting period of female mice can be brought out and prolong to Hippocampus, and the weight of uterus and ovary is increased, and can make male Mus prostate again. seminal vesicle. and the weight of levator ani obviously increases, and shows as androgen-like action.Hippocampus can strengthen the mice anoxia enduring again, reduces the activity of monoamine oxidase, MAO, reduces lipid peroxidation body content in vivo, and in addition, various Hippocampus extracts all have the effect of calcium channel blocker, by flowing in the blocking-up calcium, reaches the effect of neuroprotective unit.

The Rhizoma Anemarrhenae: be the dry rhizome of liliaceous plant Rhizoma Anemarrhenae Anemarrhena asphodeloides Bge..Spring, Qiu Erji excavate, and remove fibrous root and silt, dry.Nature and flavor hardship, sweet, cold.Return lung, stomach, kidney channel.Have clearing away heat-fire, promote the production of body fluid and moisturize.Be used for fever caused by exogenous pathogenic factors, the hyperpyrexia excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, the dryness of the intestine constipation.

Studies show that, the general unit of effective ingredient Rhizoma Anemarrhenae soap (zMS) in the Rhizoma Anemarrhenae has can improve the memory of plan Model of Dementia animal learning, rising superoxide dismutase (soD) vigor, reduce lipid peroxide (LPO) and the lipofuscin (concentration of L agate, strengthen choline second phthalein transferring enzyme (chAT) activity in the brain, and can reduce intracerebral injection A β 25 1 35 rat model cerebral tissue Zou effectively and deposit pharmacological actions such as speckle.

Radix Ophiopogonis: be the dried root of liliaceous plant Ophiopogon Radix Ophiopogonis japonicus (Thunb.) Ker-Gawl..Excavate summer, cleans, and is exposed to the sun repeatedly, banks up, and to doing very likely, removes fibrous root, drying.This product is spindle, and two ends are point slightly, long 1.5～3cm, diameter 0.3～0.6cm.Surface yellow-white or faint yellow has thin longitudinal grin.Matter is pliable and tough, the section yellow-white, and translucent, center pillar is tiny.Feeble QI perfume (or spice), sweet, the little hardship of nature and flavor is slightly cold.GUIXIN, lung, stomach are through having YIN nourishing and the production of body fluid promoting, and lung moistening clears away heart-fire.Be used for dryness of the lung dry cough, the chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.

Rhizoma Polygonati: be the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati Polygonatum kingianum Coll.etHemsl., Rhizoma Polygonati Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua Polygonatumcyrtonema Hua.By the shape difference, practise title " big Rhizoma Polygonati ", " polygonatum sibiricum Redoute ", " RHIZOMA POLYGONATI ZINGIBERIFORME ".Spring, Qiu Erji excavate, and remove fibrous root, clean, and put the boiling water part omitted and scald or steam to the saturating heart, drying.Nature and flavor are sweet, and are flat.Return spleen, lung, kidney channel.Has boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.Be used for weakness of the spleen and stomach, fatigue and asthenia, the xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.

The historic sweet in the mouth of the medication in existing more than 2000 year of Rhizoma Polygonati is flat, goes into lung, spleen, the invigorating the spleen and replenishing QI of kidney channel effect, the profit cardiopulmonary, and deficient cold and heat are controlled in bone and muscle strengthening, the pain in the lung spitting of blood, the empty lack of appetite of body after being ill, the muscles and bones weakness, rheumatalgia, the insane tinea disease of wind is the product of nourishing YIN; Pharmacological research shows that except that above-mentioned effect, Rhizoma Polygonati also has antibacterial action, especially tubercule bacillus and fungus is had significant effect, and the effect that brings high blood pressure down is arranged again simultaneously; With the active effect of superoxide dismutase (S OD) in the raising liver.

Fructus Lycii: be the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Summer, two season of autumn gather when fruit is orange red, dry in the air to rhicnosis, tan by the sun again stiff to crust, sarcocarp is soft, removes carpopodium; Or the hot blast oven drying at low temperature, remove carpopodium.Nature and flavor are sweet, and are flat.Return liver, kidney channel.Has nourishing the liver and kidney, replenishing vital essence to improve eyesight.Be used for the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.

The modern pharmacology experiment shows the effect of the anti-kidney aging of Fructus Lycii.

Carapax et Plastrum Testudinis: be carapace and the sternite of Testudinidae animal Testudinis Chinemys reevesii (Gray).All can catch the whole year, with autumn, two seasons of winter be many, kill after the seizure, or scald deadly with boiling water, strip carapace and sternite, remove residual meat, dry.Nature and flavor and salty, sweet are slightly cold.Return liver, kidney, heart channel.Has nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, the reinforcing the heart of nourishing blood.Be used for deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat is had a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and the muscles and bones flaccidity is soft, and it is forgetful to have a guilty conscience.

The Radix Polygoni Multiflori: be the dried root of polygonum multiflorum thunb Polygonum multiflorum Thunb..Autumn, two season of winter excavate when leaf is withered, and the two ends of pruning are cleaned, individual big piece, the drying of being cut into.Nature and flavor hardship, sweet, puckery, temperature.Return liver, the heart, kidney channel.Has detoxifcation, eliminating carbuncle, loosening bowel to relieve constipation.Be used for the scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.

Measure through main nutrient composition content, show and not only contain general nutrition such as a certain amount of crude protein, crude fat, free sugar and starch in the Radix Polygoni Multiflori, still be rich in the necessary trace element of multivitamin, aminoacid, inorganic salt and human body.Higher in the vitamin with vitamin B group content.Total amino acid content and Radix Panacis Quinquefolii are close, are many with glutamic acid, aspartic acid, arginine wherein.The highest arginine content is up to 2.23% at the product of giving birth to, and contains multiple elements such as the necessary zinc of human body, magnesium, calcium, ferrum, and wherein zinc element content is especially high.The Radix Polygoni Multiflori is rich in the phospholipid composition, mainly contains compositions such as lecithin lipositol, ethanolamine phospholipid and phosphatidic acid, and is wherein the highest with linoleic acid content.

Radix et Rhizoma Rhei: be the dry root and rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.The nature and flavor hardship, cold.Return spleen, stomach, large intestine, liver, pericardium channel.Has purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Be used for the excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.Be used for the conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay eliminating fire and detoxication.Be used for pathogenic fire,toxin and furuncles.The hemostasis of charred Radix Et Rhizoma Rhei cooling blood and removing stasis.Be used for heat in blood stasis of blood hemorrhage is arranged.

According to another report, emodin can suppress TNP by improving the p27 level, induces kidney mesangial cell (mesangial cell, Mc) hypertrophy.

Chrysophanic acid (Rhein, 4.5 1 dihydroxyanthraquinone are called for short RH) belongs to single Herba Alii fistulosi nuclear class l, and the 8 one the second light industry bureau base Herba Alii fistulosis derivant of waking up is the effective ingredient of purifying out from multiple Chinese medicine separation such as Radix Et Rhizoma Rhei, Radix Polygoni Multiflori, Rhizoma Polygoni Cuspidati.The structural formula of RH, RH contain two light bases and a carbonyl, and polarity is stronger, has electrochemical redox character.Chrysophanic acid (RH) mainly is distributed in the few section plant for the wake up monomer of derivant of Herba Alii fistulosi, be plurality of Chinese such as Radix Et Rhizoma Rhei, Radix Polygoni Multiflori, Rhizoma Polygoni Cuspidati mainly contain one of effective constituent.In recent years, discover that it has to protect the liver and anti-hepatic fibrosis, effects such as control diabetic nephropathy (DN), antitumor, to have clinical medical value in view of its pharmacological action more widely.

Herba Epimedii: be the dry aerial parts of Berberidaceae plant Herba Epimedii Epimedium brevicomum Maxim., arrow leaf Herba Epimedii Epimediumsagittatum (Sieb.et Zucc.) Maxim., pubescence Herba Epimedii Epimedium pubescens Maxim., Epimedium wushanense Epimedium wushanenseT.S.Ying or Herba Epimedii Epimedium koreanum Nakai.Tap when stem and leaf is luxuriant between summer, autumn, remove thick stalk and impurity, dry or dry in the shade.Nature and flavor suffering, sweet, temperature.Return liver, kidney channel.Has kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Be used for impotence and seminal emission, the muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension disease.

Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Autumn end excavates, and removes fibrous root and silt, treat that moisture evaporates slightly after, tie into wisp, last canopy is with pyrotechnics smoke-dried beancurd slowly.Nature and flavor are sweet, hot, temperature.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.The Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.Be used for the amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

Studies show that Radix Angelicae Sinensis as can be known, can remove ultra-oxygen anion free radical (02), light basic free radical, reduce Hepar Mus homogenate level of lipid oxygen-derived free radicals, mitochondrial effect, and by above-mentioned effect protective wire plastochondria.According to another discovering, Radix Angelicae Sinensis not only has traditional pharmacological effects such as nourishing blood and promoting blood circulation, also has antioxidation, removes free radical, cholesterol reducing, the neontology effects such as information transmission adjusting of participation signaling system.

Spina Gleditsiae: be the Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..Warm in nature, acrid in the mouth.Has the detumescence poison holding, evacuation of pus, parasite killing.Be used for carbuncle from the beginning of or pusization do not burst; External treatment scabies leprosy.

It is gleditschiasaponin B-G (gleditsiasaaponin B-G), Palmic acid (palmitic acid), hard ester acid, oleic acid, inferior sterol, sitosterol, nonacosane (nonacosane) etc. that Spina Gleditsiae includes chemical constituent.

Herba Verbenae: be the aerial parts of Verenaceae plant Herba Verbenae Verbena officinalis L..Perennial herb, cool in nature, bitter in the mouth.Herb contains venbenalin verbenalin) ey 5-hydroxy herba verbenae glycoside; Other contains emulsin, tannin; Leaf contains gland glycoside (adenoside), beta-carotene again.Has promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, detoxifcation, inducing diuresis to remove edema.Be used for lump in the abdomen, amenorrhea dysmenorrhea, malaria, sore throat, carbuncle, edema, pyretic stranguria.

The present invention adopts nine age in days androgens to cause not, and pregnant rat (9 d-A SR) animal model carries out effect experiment, the result shows: the water-soluble part of the extraction of the used Chinese medicine of the present invention can make form, the weight of rat ovary take place obviously to change, reproductive function is recovered, ovulation rate increases, lose weight, and can make follicule-stimulating hormone (FSH) (FSH), lutropin (LH), leptin, estradiol (E2), the equivalent recovery of androgen (T) normally, the induced ovulation rate reaches 60%.Show that this Chinese medicine composition can be by playing a role to maincenter and each horizontal corrdination of periphery, the adjustment energy is unbalance and reproduction low (low GnRH-FSH or LH secretion).

Chinese medicine composition of the present invention has shown curative effect preferably in long-term clinical experiment treatment, can improve patient's xerostomia significantly, the interior-heat disease is alleviated, agitation, insomnia, weak, subjective symptoms such as stomach is received.And warp is measured and is all decreased patient's blood Ins level, waist-to-hipratio value (WHR), Body Mass Index (BMI),, logT testosterone/E2 estradiol reduces obviously, and form, the weight of ovary are recovered to some extent.Patients more than half recover rule menstruation companion two-way type basal body temperature.And untoward reaction do not appear in the patient,, so the patient all is willing to adhere to long-term prescription.

The specific embodiment

Embodiment 1

Hippocampus 0.6g Rhizoma Anemarrhenae 18g 15g Radix Ophiopogonis

Rhizoma Polygonati 12g Fructus Lycii 12g Rhizoma Coptidis 9g

Carapax et Plastrum Testudinis 15g Radix Polygoni Multiflori 27g Radix Et Rhizoma Rhei 6g

Herba Epimedii 24g Radix Angelicae Sinensis 15g Spina Gleditsiae 18g

Herba Verbenae 27g

After Carapax et Plastrum Testudinis added 3 times of amounts of water and decoct 1 hour, leaching filtrate, residue adds all medical materials except that Hippocampus again, adds 8,6 times of amounts of water and extracts secondary, each 1.5 hours, filter, merging filtrate is concentrated into relative density and is about at 1.35 o'clock, after baking oven is dried to dry extract, adds through being ground into the Hippocampus powder of fine powder, cross 60 mesh sieves, filled capsules, be pressed into tablet or make granule.

Embodiment 2

Hippocampus 1g Rhizoma Anemarrhenae 9g 9g Radix Ophiopogonis

Rhizoma Polygonati 27g Fructus Lycii 27g Rhizoma Coptidis 6g

Carapax et Plastrum Testudinis 27g Radix Polygoni Multiflori 12g Radix Et Rhizoma Rhei 9g

Herba Epimedii 12g Radix Angelicae Sinensis 9g Spina Gleditsiae 24g

Herba Verbenae 15g

After Carapax et Plastrum Testudinis added 3 times of amounts of water and decoct 1 hour, leaching filtrate, residue adds all medical materials except that Hippocampus again, adds 8,6 times of amounts of water and extracts secondary, each 1.5 hours, filter, merging filtrate is concentrated into relative density and is about at 1.35 o'clock, after baking oven is dried to dry extract, adds through being ground into the Hippocampus powder of fine powder, cross 60 mesh sieves, filled capsules, be pressed into tablet or make granule.

Embodiment 3

Hippocampus 2.4g Rhizoma Anemarrhenae 12g 12g Radix Ophiopogonis

Rhizoma Polygonati 18g Fructus Lycii 18g Rhizoma Coptidis 9g

Carapax et Plastrum Testudinis 12g Radix Polygoni Multiflori 18g Radix Et Rhizoma Rhei 12g

Herba Epimedii 18g Radix Angelicae Sinensis 12g Spina Gleditsiae 12g

Herba Verbenae 18g

Preparation method: after Carapax et Plastrum Testudinis added 3 times of amounts of water and decoct 1 hour, leaching filtrate, residue adds all medical materials except that Hippocampus again, adds 8,6 times of amounts of water and extracts secondary, each 1.5 hours, filter, merging filtrate is concentrated into relative density and is about at 1.35 o'clock, after baking oven is dried to dry extract, adds through being ground into the Hippocampus powder of fine powder, cross 60 mesh sieves, filled capsules, be pressed into tablet or make granule.

Claims (6)

1, a kind of Chinese medicine composition for the treatment of high insulin polycystic ovary syndrome is characterized in that being made by following raw material medicaments: Hippocampus, the Rhizoma Anemarrhenae, Radix Ophiopogonis, Rhizoma Polygonati, Fructus Lycii, Rhizoma Coptidis, Carapax et Plastrum Testudinis, the Radix Polygoni Multiflori, Radix Et Rhizoma Rhei, Herba Epimedii, Radix Angelicae Sinensis, Spina Gleditsiae, Herba Verbenae.

2, the Chinese medicine composition of treatment high insulin polycystic ovary syndrome as claimed in claim 1 is characterized in that the weight proportion of described crude drug is:

Hippocampus 0.3-3g, Rhizoma Anemarrhenae 6-20g, Radix Ophiopogonis 6-18g, Rhizoma Polygonati 9-30g, Fructus Lycii 9-30g, Rhizoma Coptidis 3-12g, Carapax et Plastrum Testudinis 9-30g, Radix Polygoni Multiflori 9-30g, Radix Et Rhizoma Rhei 3-15g, Herba Epimedii 9-30g, Radix Angelicae Sinensis 6-20g, Spina Gleditsiae 9-30g, Herba Verbenae 9-30g.

3, the Chinese medicine composition of treatment high insulin polycystic ovary syndrome as claimed in claim 1 is characterized in that the weight proportion of described crude drug is:

Hippocampus 0.6g Rhizoma Anemarrhenae 18g 15g Radix Ophiopogonis

Rhizoma Polygonati 12g Fructus Lycii 12g Rhizoma Coptidis 9g

Carapax et Plastrum Testudinis 15g Radix Polygoni Multiflori 27g Radix Et Rhizoma Rhei 6g

Herba Epimedii 24g Radix Angelicae Sinensis 15g Spina Gleditsiae 18g

Herba Verbenae 27g.

4, the Chinese medicine composition of treatment high insulin polycystic ovary syndrome as claimed in claim 1 is characterized in that the weight proportion of described crude drug is:

Hippocampus 1g Rhizoma Anemarrhenae 9g 9g Radix Ophiopogonis

Rhizoma Polygonati 27g Fructus Lycii 27g Rhizoma Coptidis 6g

Carapax et Plastrum Testudinis 27g Radix Polygoni Multiflori 12g Radix Et Rhizoma Rhei 9g

Herba Epimedii 12g Radix Angelicae Sinensis 9g Spina Gleditsiae 24g

Herba Verbenae 15g.

5, the Chinese medicine composition of treatment high insulin polycystic ovary syndrome as claimed in claim 1 is characterized in that the weight proportion of described crude drug is:

Hippocampus 2.4g Rhizoma Anemarrhenae 12g 12g Radix Ophiopogonis

Rhizoma Polygonati 18g Fructus Lycii 18g Rhizoma Coptidis 9g

Carapax et Plastrum Testudinis 12g Radix Polygoni Multiflori 18g Radix Et Rhizoma Rhei 12g

Herba Epimedii 18g Radix Angelicae Sinensis 12g Spina Gleditsiae 12g

Herba Verbenae 18g.

6, the preparation method of Chinese medicine composition as claimed in claim 1, by following step: after Carapax et Plastrum Testudinis added 3 times of amounts of water and decoct 1 hour, leaching filtrate, residue adds all medical materials except that Hippocampus again, add water 8 or 6 times of amount extraction secondaries, each 1.5 hours, filter, merging filtrate is concentrated into relative density and is about 1.35, oven drying is to dry extract, add the Hippocampus fine powder, cross 60 mesh sieves, filled capsules or tabletting or make granule.