CN106266109B - It is a kind of to treat Chinese medicine composition of calculi in urinary system and preparation method thereof - Google Patents
It is a kind of to treat Chinese medicine composition of calculi in urinary system and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention provides a kind of Chinese medicine composition for treating calculi in urinary system, it is made up of the Chinese medicine of following weight：3 10 parts of 10 30 parts of Desmodium styracifolium, 10 30 parts of the membrane of a chicken's gizzard, extra large 10 30 parts of gold sand rattan, 15 40 parts of pyrrosia lingua, extra large 5 20 parts of gold sand, 5 20 parts of excrementum pteropi, 5 15 parts of Fructus Aurantii, 5 15 parts of dried orange peel, 5 20 parts of talcum powder and Radix Glycyrrhizae.The Chinese medicine composition of the present invention has therapeutic effect to the calculi in urinary system including kidney stone, ureteral calculi, vesical calculus and urethral calculus etc., and evident in efficacy, toxic and side effect is small, and preparation method raw material is easy to get, step is simple, reproducible.
Description
Technical field
The invention belongs to field of traditional Chinese, in particular to a kind of Chinese medicine composition for treating calculi in urinary system and
Its preparation method.
Background technology
Calculus is in the catheter lumen in human body or animal body or luminal organ (such as kidney, ureter, gall-bladder or bladder)
Chamber in the solid mass that is formed.It is mainly seen in gall-bladder and bladder, renal plevis, also seen in pancreas conduit, salivary ducts etc.
In chamber.Calculus is made up of inorganic salts or organic matter.Typically there is a core in calculus, by the epithelial cell come off, bacterial aggregate, post
Infested ovum or polypide, excrement block or foreign matter composition, inorganic salts or organic matter are deposited on core layer by layer again.Due to afflicted organ not
Together, contained by the mechanism of calculus composition, shape, quality, influence to body etc. are differed.Generally speaking, calculus can
Cause tube chamber to block, influence the discharge of afflicted organ's liquid, produce the symptoms such as pain, bleeding or secondary infection.
Calculi in urinary system is one of most common urological diseases, with the characteristics of the incidence of disease is high, the cause of disease is complicated.Root
It can be divided into kidney stone, ureteral calculi, vesical calculus and urethral calculus etc. according to position where calculus.Calculi in urinary system in kidney and
Formed in bladder.Upper urinary stone and the Forming Mechanism of calculus of lower urinary tract, the cause of disease, calculus composition and epidemiology have significance difference
It is different.Most of upper urinary stone is calcinm oxalate calculus.Magnesium ammonium phosphate calculus is common compared with upper urinary tract in vesical calculus.Ultrasonic rubble
Art, ureter endoscopic stone extraction technique, percutaneous nephrolithotomy etc. achieve good development, effect in terms of calculi therapy in recent years
Significantly.Particularly laser lithotripsy turns into applies most kidney stone treatment technologies in recent years.But the recurrence rate of calculus and control again
Rate is higher than traditional operation, and there is traumatic and complication.
Calculi in urinary system often shows as odynuria, urine color muddiness or color, pain in the back, with frequent micturition, urgent urination, yellow,greasy and thin fur, arteries and veins
Number is lubricated, obstruction and renal failure can be caused when serious.Kidney stone, ureteral calculi, vesical calculus and urethral calculus etc. belong to
" urolithiasis " of " stranguria ", " sand pouring ", " blood strangury " and " stomachache ", the scope of " waist is swollen " in motherland's medical science.The hair of stone in urinary system
Raw reason successive dynasties books are recorded quite in detail,《The General Treatise on the Cause and Symptoms of Diseases》Cloud:" Zhu Linzhe, by and bladder heat therefore.”《Huatuo's Zhongzang classic》Cloud:It is " empty
Feel frustrated, heat symptoms caused by an exopathgen crescendo, knot is poly- to form sandstone, and and for example water is got salt by evaporation of sea-water, boil the salt off the water, and fiery too water is few, salt gradually Cheng Shi etc." its disease is more accumulates long because damp and hot
Urine is decocted, becomes sandstone and blocks caused by urinary tract, therefore urinates involved and abstruse and interrupts.It is high with western medical treatment calculi in urinary system price
Unlike expensive, complication is more, TCM Therapy curative effect affirmative, non-invasive, adverse reaction are small, are vast stone in urinary system
Patient is received.
Doctor trained in Western medicine thinks calculi in urinary system and dietary structure, Water intake, weather, heredity, metabolism, obstruction and urinary tract infections
It is relevant Deng many factors.And the traditional Chinese medical science thinks that the etiology and pathogenesis of calculi in urinary system is mainly kidney deficiency, bladder qi dysfunction, damp and hot accumulate
Tie, decoct body fluid, the with the passing of time moon tire out, gather and form stone.The research for treating stone in urinary system with people deepens continuously and developed, and treats
Method mainly has clearing heat and promoting diuresis to arrange method, loins-strengthening and kidney-invigorating method, warming kidney for duresis method, Invigorating Qi, yin Method, regulating qi-flowing for activating stagnancy method, promoting blood circulationization
Stasis of blood method, relieving spasm to stop pain method etc..
The content of the invention
In order to solve technical problem of the prior art, the invention provides a kind of Chinese medicine group for treating calculi in urinary system
Compound, it has diuresis promoting, regulating qi to disperse stagnation, the effect of promoting blood circulation and stopping pain, to including kidney stone, ureteral calculi, vesical calculus
And the calculi in urinary system including urethral calculus etc. has therapeutic effect, and evident in efficacy, toxic and side effect is small.In addition, of the invention
The preparation method raw material of Chinese medicine composition is easy to get, step is simple, reproducible.
To realize the purpose of the application, the present invention is realized by following technical schemes.
On the one hand, the invention provides a kind of Chinese medicine composition for treating calculi in urinary system, it is by Desmodium styracifolium, chicken
Gold, extra large gold sand rattan and pyrrosia lingua are made.
It has been found that on the basis of Desmodium styracifolium, the membrane of a chicken's gizzard, extra large gold sand rattan, pyrrosia lingua, the further extra large gold sand of addition,
Excrementum pteropi, Fructus Aurantii, dried orange peel, talcum powder and Radix Glycyrrhizae, can preferably play diuresis promoting, the effect of heat-clearing stasis eliminatings.
As a preferred embodiment, the Chinese medicine system that Chinese medicine composition of the invention is made up of following parts by weight
Into：10-30 parts of Desmodium styracifolium, 10-30 parts of the membrane of a chicken's gizzard, extra large 10-30 parts of gold sand rattan, 15-40 parts of pyrrosia lingua, extra large 5-20 parts of gold sand, five
3-10 parts of clever fat 5-20 parts, 5-15 parts of Fructus Aurantii, 5-15 parts of dried orange peel, 5-20 parts of talcum powder and Radix Glycyrrhizae.
It is highly preferred that the Chinese medicine that the Chinese medicine composition of the present invention is made up of following parts by weight is made：Desmodium styracifolium 15-25
Part, 15-25 parts of the membrane of a chicken's gizzard, extra large 15-25 parts of gold sand rattan, 20-30 parts of pyrrosia lingua, extra large 12-18 parts of gold sand, 12-18 parts of excrementum pteropi, Fructus Aurantii
3-8 parts of 7-12 parts, 7-12 parts of dried orange peel, 12-18 parts of talcum powder and Radix Glycyrrhizae.
Most preferably, the Chinese medicine that Chinese medicine composition of the invention is made up of following parts by weight is made：20 parts of Desmodium styracifolium, chicken
Interior golden 20 parts, extra large 20 parts of gold sand rattan, 25 parts of pyrrosia lingua, extra large 15 parts of gold sand, 15 parts of excrementum pteropi, 10 parts of Fructus Aurantii, 10 parts of dried orange peel, talcum powder
15 parts and 5 parts of Radix Glycyrrhizae.
In the pharmaceutical composition of the present invention, the source of each Chinese medicine material and effect are described below.
Desmodium styracifolium：For legume Desmodium styracifolium Desmodium styracifolium (Osh.) Merr. dryly
Upper part.Nature and flavor are sweet, light, cool.Return liver, kidney, bladder warp.With removing damp-heat, effect of inducing diuresis for treating strangurtia.For heat gonorrhea, sand drenches,
Urolithiasis, difficulty and pain in micturition, oedema oliguria, jaundice, lithangiuria.
The membrane of a chicken's gizzard：For Phasianidae animal family chicken Gallus gallus domesticus Brisson drying inner wall of sandbag.
Nature and flavor are sweet, put down.Returns spleen, stomach, small intestine, bladder warp.With stomach strengthening and digestion promoting, effect of arresting seminal emission.For dyspepsia, vomiting is rushed down
Dysentery, infantile malnutrition, the enuresis, seminal emission.
Herba lygodii：For the herb of Lygodiaceae plant Lygodium japonicum.Nature and flavor are sweet, tremble with fear.With clearing heat and detoxicating, promoting diuresis for stranguria
Effect.Control under urinary tract infections, lithangiuria, gonorrhoea band, difficult urination, nephritic dropsy, jaundice with damp-heat pathogen, cold, fever, cough, pharynx
Larynx swells and ache, enteritis, dysentery, scalds, erysipelas.
Pyrrosia lingua：For Plants of Polypodiaceae pyrrosia sheareriChing Pyrrosia sheareri (Bak.) Ching, pyrrosia lingua Pyrrosia
Lingua (Thunb.) Farwell or pyrrosia petiolosaChing Pyrrosia petiolosa (Christ) Ching dried leaf.Nature and flavor
Sweet, hardship, is slightly cold.Return lung, bladder warp.With inducing diuresis for treating strangurtia, effect of clearing away heat to stop bleeding.For heat gonorrhea, blood strangury, urolithiasis, urine is not
It is logical, the puckery pain of drip is drenched, is spitted blood, bleeding from five sense organs or subcutaneous tissue, hematuria, uterine bleeding, dyspnea and cough due to lung-heat.
Lygodium japonicum：For Lygodiaceae plant Lygodium japonicum Lygodium japonicum (Thunb.) Sw. drying and ripening spore
Son.Nature and flavor are sweet, salty, tremble with fear.Return bladder, small intestinl channel.With eliminating dampness and heat, effect for the treatment of stranguria analgesic.For heat gonorrhea, sand drenches, urolithiasis,
Blood strangury, cream drenches, Urethra astringent pain.
Excrementum pteropi：For flying squirrel section animal trogopterus xanthipes Trogopterus Xanthipes Milne-Edwards or flying squirrel
The small flying squirrel Pteromys volans L. of section animal drying excrement.Nature and flavor are sweet, temperature.With promoting blood circulation to remove blood stasis, the work(of fries charcoal hemostasis
Effect.For trusted subordinate's extravasated blood, dysmenorrhoea, blood stasis, postpartum congestion and abdominal pain；Fry charcoal and control metrostaxis；Traumatic injury is controlled in external application,
Snake, insect bite.
Fructus Aurantii：For rutaceae bitter orange Citrus aurantium L. and its drying immature fruit of variety.
Bitter in taste, pungent, acid, temperature.Returns spleen, stomach.With regulating the flow of QI to ease the stomach, effect of the stagnant dissipate-swelling of row.For the chest side of body stagnation of the circulation of vital energy, turgor pain,
Stop in accumulation of food in the stomach and intes tine due to indigestion, phlegm and retained fluid；Gastroptosis, prolapse of the anus, sub-official prolapses.
Dried orange peel：For rutaceae orange Citrus reticulata Blanco and its drying and ripening of variety really
Skin.It is bitter in taste, pungent, temperature.Return lung, the spleen channel.With regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm effect.For chest gastral cavity turgor, deficiency of food is vomited and diarrhoea,
Coughing with a lot of sputum.
Talcum powder：Be talcum it is featured purification, crush, drying be made.Nature and flavor are sweet, light, tremble with fear.Return bladder, lung, stomach.Tool
There are inducing diuresis for treating strangurtia, clearing away summerheat, effect of clearing damp sore.For heat gonorrhea, urolithiasis urinates hot puckery pain, summer-heat and damp polydipsia, damp and hot watery diarrhea；
Control eczema, wet sore, prickly heat outside.
Radix Glycyrrhizae：For glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza
Inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L. dry root.Nature and flavor are sweet, put down.The thoughts of returning home, lung, spleen, stomach
Through.It is clearing heat and detoxicating with invigorating the spleen and benefiting qi, expelling phlegm and arresting coughing, relieving spasm to stop pain, effect of coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, burnout is weary
Power, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
In the Chinese medicine preparation of the present invention, there is heat-clearing to remove for Desmodium styracifolium, Herba lygodii, pyrrosia lingua, Lygodium japonicum, talcum powder
Wet, inducing diuresis for treating strangurtia, effect of clearing away heat to stop bleeding, the membrane of a chicken's gizzard, Fructus Aurantii, dried orange peel and Radix Glycyrrhizae have effects that regulating qi-flowing for activating stagnancy, strengthening the spleen and stomach, five
Clever fat has effects that promoting blood circulation to remove blood stasis.All medicines merge, and diuresis promoting, regulating qi to disperse stagnation, the effect of promoting blood circulation and stopping pain are played altogether, to including kidney
Calculi in urinary system including calculus, ureteral calculi, vesical calculus and urethral calculus etc. has therapeutic effect, and curative effect is aobvious
Work, toxic and side effect are small.
For the Chinese medicine composition of the present invention, the conventional Chinese medicine in this area can further be made after active component is extracted
Type, such as decoction, pill, tablet, capsule, pill, powder, granule, oral liquid.
Second aspect comprises the following steps there is provided the method for preparing pharmaceutical composition of the present invention, this method：
A, weigh Desmodium styracifolium, the membrane of a chicken's gizzard, extra large gold sand rattan, pyrrosia lingua, extra large gold sand, excrementum pteropi, Fructus Aurantii, dried orange peel, talcum powder and
Radix Glycyrrhizae, it is standby；
B, the membrane of a chicken's gizzard, extra large gold sand, talcum powder be crushed respectively after drying, and then cross 100-200 mesh sieves and obtain fine powder, it is standby；
C, will Desmodium styracifolium, extra large gold sand rattan, pyrrosia lingua, excrementum pteropi, Fructus Aurantii, dried orange peel and Radix Glycyrrhizae crush after mix, plus 6-10 times
The decocting of volume is boiled twice, first time 2-5 hour, second 0.5-3 hours, and collecting decoction simultaneously retains filter residue, filters decocting liquid, filter
It is standby that liquid is concentrated under reduced pressure into the clear cream that relative density is 1.12-1.18 (60 DEG C)；
D, the 45-60% ethanol that step C filter residue is added to 4-8 times of volume, refluxing extraction 2 times are each 1-3 hours, filtering,
Merging filtrate, then vacuum distillation removes ethanol, and it is standby to be concentrated into the clear cream that relative density is 1.12-1.18 (60 DEG C)；
E, the clear cream merging by step C and step D, stir, and are heated to 50-80 DEG C and cross the filter of 200-400 mesh sieves while hot
Cross, filtrate is spray-dried, produce spray powder, then add step B fine powder, cross 100-200 mesh sieves and be well mixed, i.e.,
.
For step E spray drying, condition preferably is：80-100 DEG C of outlet temperature, 130-160 DEG C of inlet temperature,
Flow velocity 0.2-0.6kg/min, 23-30 DEG C of feed temperature.
For the mixed-powder obtained by step E, pharmaceutically acceptable auxiliary material is optionally added into, decoction, pill, piece is made
Agent, capsule, pill, powder, granule, oral liquid.
Further, use of the Chinese medicine composition of the present invention in the medicine for preparing treatment calculi in urinary system is additionally provided
On the way.
Compared with prior art, it is of the invention to include following advantage：
(1), the present invention on the basis of China's traditional Chinese medicine, scientific and reasonable formula, Desmodium styracifolium, Herba lygodii, pyrrosia lingua,
Lygodium japonicum, talcum powder have effects that removing damp-heat, inducing diuresis for treating strangurtia, clearing away heat to stop bleeding, and the membrane of a chicken's gizzard, Fructus Aurantii, dried orange peel and Radix Glycyrrhizae have
Effect of regulating qi-flowing for activating stagnancy, strengthening the spleen and stomach, excrementum pteropi has effects that promoting blood circulation to remove blood stasis.All medicines merge, and diuresis promoting, promoting the circulation of qi are played altogether
The effect of the stasis of blood, promoting blood circulation and stopping pain, to the urinary system including kidney stone, ureteral calculi, vesical calculus and urethral calculus etc.
Calculus has therapeutic effect, and evident in efficacy, toxic and side effect is small.
(2), Chinese medicine composition of the invention is after water boiling and extraction, and active constituent content is higher, and can further make
The standby form for being easier to receive into patients such as decoction, pill, tablet, capsule, pill, powder, granule, oral liquids, from
And the drug compliance of patient is more preferable.
(3), for preparing, the method raw material of Chinese medicine preparation of the present invention is easy to get, step is simple, reproducible, meets industry
The need for production.
Embodiment
To make the object, technical solutions and advantages of the present invention clearer, below in conjunction with tool of the embodiment to the present invention
Body embodiment is clearly and completely described.
Embodiment 1：
Formula and parts by weight composition：20 parts of Desmodium styracifolium, 20 parts of the membrane of a chicken's gizzard, extra large 20 parts of gold sand rattan, 25 parts of pyrrosia lingua, extra large gold sand
5 parts of 15 parts, 15 parts of excrementum pteropi, 10 parts of Fructus Aurantii, 10 parts of dried orange peel, 15 parts of talcum powder and Radix Glycyrrhizae.
Preparation method：A, weigh Desmodium styracifolium, the membrane of a chicken's gizzard, extra large gold sand rattan, pyrrosia lingua, extra large gold sand, excrementum pteropi, Fructus Aurantii, dried orange peel,
Talcum powder and Radix Glycyrrhizae, it is standby；B, the membrane of a chicken's gizzard, extra large gold sand, talcum powder be crushed respectively after drying, and then cross 100 mesh sieves and obtain fine powder,
It is standby；C, will Desmodium styracifolium, extra large gold sand rattan, pyrrosia lingua, excrementum pteropi, Fructus Aurantii, dried orange peel and Radix Glycyrrhizae crush after mix, plus 6 times of volumes
Decocting is boiled twice, and 3 hours for the first time, second 1 hour, collecting decoction simultaneously retained filter residue, filtered decocting liquid, and filtrate decompression is concentrated into
Relative density is standby for the clear cream of 1.15 (60 DEG C)；D, 60% ethanol that step C filter residue is added to 6 times of volumes, refluxing extraction 2
It is secondary, 1 hour every time, filtering, merging filtrate, then vacuum distillation removes ethanol, and is concentrated into relative density for 1.15 (60 DEG C)
Clear cream it is standby；E, the clear cream merging by step C and step D, stir, and are heated to 60 DEG C and cross the filtration of 200 mesh sieves, filter while hot
Liquid is spray-dried, and produces spray powder, and spray drying condition is：80 DEG C of outlet temperature, 130 DEG C of inlet temperature, flow velocity
Then 0.3kg/min, 25 DEG C of feed temperature adds step B fine powder, crosses 100 mesh sieves and is well mixed；Add appropriate lactose, wheat
Bud dextrin and magnesium stearate, are well mixed, direct tablet compressing produces tablet.
Embodiment 2：
Formula and parts by weight composition：15 parts of Desmodium styracifolium, 25 parts of the membrane of a chicken's gizzard, extra large 25 parts of gold sand rattan, 22 parts of pyrrosia lingua, extra large gold sand
4 parts of 16 parts, 16 parts of excrementum pteropi, 8 parts of Fructus Aurantii, 8 parts of dried orange peel, 16 parts of talcum powder and Radix Glycyrrhizae.
Preparation method：A, weigh Desmodium styracifolium, the membrane of a chicken's gizzard, extra large gold sand rattan, pyrrosia lingua, extra large gold sand, excrementum pteropi, Fructus Aurantii, dried orange peel,
Talcum powder and Radix Glycyrrhizae, it is standby；B, the membrane of a chicken's gizzard, extra large gold sand, talcum powder be crushed respectively after drying, and then cross 200 mesh sieves and obtain fine powder,
It is standby；C, will Desmodium styracifolium, extra large gold sand rattan, pyrrosia lingua, excrementum pteropi, Fructus Aurantii, dried orange peel and Radix Glycyrrhizae crush after mix, plus 8 times of volumes
Decocting is boiled twice, and 4 hours for the first time, second 2 hours, collecting decoction simultaneously retained filter residue, filtered decocting liquid, and filtrate decompression is concentrated into
Relative density is standby for the clear cream of 1.12 (60 DEG C)；D, 50% ethanol that step C filter residue is added to 6 times of volumes, refluxing extraction 2
It is secondary, 2 hours every time, filtering, merging filtrate, then vacuum distillation removes ethanol, and is concentrated into relative density for 1.12 (60 DEG C)
Clear cream it is standby；E, the clear cream merging by step C and step D, stir, and are heated to 80 DEG C and cross the filtration of 200 mesh sieves, filter while hot
Liquid is spray-dried, and produces spray powder, and spray drying condition is：100 DEG C of outlet temperature, 150 DEG C of inlet temperature, flow velocity
Then 0.5kg/min, 28 DEG C of feed temperature adds step B fine powder, crosses 200 mesh sieves and is well mixed；Add appropriate cornstarch
And talcum powder, it is well mixed, fills to capsule shells, produce capsule.
Embodiment 3：
Formula and parts by weight composition：23 parts of Desmodium styracifolium, 23 parts of the membrane of a chicken's gizzard, extra large 23 parts of gold sand rattan, 23 parts of pyrrosia lingua, extra large gold sand
6 parts of 12 parts, 12 parts of excrementum pteropi, 10 parts of Fructus Aurantii, 10 parts of dried orange peel, 12 parts of talcum powder and Radix Glycyrrhizae.
Preparation method：A, weigh Desmodium styracifolium, the membrane of a chicken's gizzard, extra large gold sand rattan, pyrrosia lingua, extra large gold sand, excrementum pteropi, Fructus Aurantii, dried orange peel,
Talcum powder and Radix Glycyrrhizae, it is standby；B, the membrane of a chicken's gizzard, extra large gold sand, talcum powder be crushed respectively after drying, and then cross 100 mesh sieves and obtain fine powder,
It is standby；C, will Desmodium styracifolium, extra large gold sand rattan, pyrrosia lingua, excrementum pteropi, Fructus Aurantii, dried orange peel and Radix Glycyrrhizae crush after mix, plus 7 times of volumes
Decocting is boiled twice, and 2 hours for the first time, second 2 hours, collecting decoction simultaneously retained filter residue, filtered decocting liquid, and filtrate decompression is concentrated into
Relative density is standby for the clear cream of 1.18 (60 DEG C)；D, 45% ethanol that step C filter residue is added to 6 times of volumes, refluxing extraction 2
It is secondary, 3 hours every time, filtering, merging filtrate, then vacuum distillation removes ethanol, and is concentrated into relative density for 1.18 (60 DEG C)
Clear cream it is standby；E, the clear cream merging by step C and step D, stir, and are heated to 50 DEG C and cross the filtration of 200 mesh sieves, filter while hot
Liquid is spray-dried, and produces spray powder, and spray drying condition is：90 DEG C of outlet temperature, 140 DEG C of inlet temperature, flow velocity
Then 0.6kg/min, 26 DEG C of feed temperature adds step B fine powder, crosses 100 mesh sieves and is well mixed；Add appropriate malt paste
Essence, starch and honey, pill is made after being well mixed.
Test example 1：Animal model test
1st, to the influence of rat kidney stone
(1), test method：60 health Wistar rats are randomly selected, body weight 180-250g is randomly divided into 4 groups, every group
15.Blank control group：15, gavage physiological saline；Model control group：15, gavage physiological saline；Positive controls：15
Only, the aqueous solution of gavage compound stranguria-treating and calculus-removing tablet, dosage 25g/kg；Of the present invention group：15, the tablet of gavage the embodiment of the present application 1
The aqueous solution, dosage 25g/kg.The daily gavage of every group of rat 1 time, continuous 30 days.During raising, model control group, positive controls
With of the present invention group in 100g feeds add ethylene glycol 2g and ammonium chloride 1g, and weekly intramuscular injection vitamine D3 once, dosage 3
Ten thousand units/kg, to form kidney stone model.Experimental animal is put to death after off-test, double kidneys is taken out, longitudinally splits, observation kidney is cutd open
Face whether there is obvious crystalline deposit thing and free calculus or calcified plaque.It is divided into according to the degree of the number of calculus and kidney injury
5 grades below, and model control group, positive controls and present invention group are given a mark.
I grades：Cortex renis, medullary substance and renal papilla are without visible calculus and crystalline deposit thing, and kidney profile is without exception to be become
Change, remember 0 point；
II grades：Cortex renis or medullary substance it is visible it is a small amount of be dispersed in crystalline deposit thing, remember 1 point；
III level：Cortex renis, medullary substance and the visible crystalline deposit thing of renal plevis have small free crystallization, remember 2 points；
IV grades：Kidney section is visible compared with polycrystalline, and has free calculus, the visible calcified plaque of renal papilla, pyclectasis product
Water, remembers 3 points；
V grades：The visible mass crystallization of cortex renis, medullary substance, there is free calculus, and the visible calcified plaque of renal papilla, renal plevis is obvious
Ponding is expanded, 4 points are remembered.
(2), result of the test：As shown in table 1, present invention group and model control group (P<0.01) with positive controls (P<
0.05) there is significant difference, Chinese medicine composition of the invention can substantially prevent the kidney stone of the inductions such as ethylene glycol and ammonium chloride
Formed, and the calculus rate of rat is decreased.
Influence of each group of table 1 to rat kidney stone
| Group | Size of animal (only) | Dosage (g/kg) | Kidney stone scores (dividing) | Calculus rate (%) |
| Blank control group | 15 | 0 | 0 | 0 |
| Model control group | 15 | 0 | 3.02±1.58 | 91.2% |
| Positive controls | 15 | 25.0 | 0.43±0.54 | 30.7% |
| Of the present invention group | 15 | 25.0 | 0.29±0.21 | 21.5% |
2nd, to the influence of rat urine
(1), test method：45 health Wsiatar rats are randomly selected, body weight 180-250g is randomly divided into 3 groups, sky
White other 15 of control group, positive controls and instant component.Fasting can't help water 10 days, and then every rat oral gavage gives 5%
Glucose saline 3mL/100g, after 30 minutes, to blank control group gavage physiological saline, to positive controls gavage compound urolithiasis
The aqueous solution of logical piece, dosage 25g/kg, to the aqueous solution of the tablet of present invention group gavage the embodiment of the present application 1, dosage 25g/kg.Give
Rat lower abdomen is oppressed after medicine, remaining urine is drained, is subsequently placed in metabolic cage, the urine of 5 hours is collected, and oppresses rat lower abdomen and is drained
Remaining urine, measures the volume of urine of each group rat respectively.
(2), result of the test：As shown in table 2, present invention group and blank control group (P<0.01) with positive controls (P<
0.05) there is significant difference, Chinese medicine composition of the invention can substantially increase the urination amount of rat, shows that there is significant profit
Urine is acted on.
Influence of each group of table 2 to rat urine
3rd, to the influence of rat ear swelling
(1), test method：45 healthy kunming mices are randomly selected, body weight 22-30g is randomly divided into 3 groups.Blank control
Group：15, gavage physiological saline；Positive controls：15, the aqueous solution of gavage compound stranguria-treating and calculus-removing tablet, dosage 25g/kg；This hair
Bright group：15, the aqueous solution of the tablet of gavage the embodiment of the present application 1, dosage 25g/kg.After administration 1 hour, to a left side for every rat
Ear injects 2% croton oil mixture 0.05mL and causes left ear inflammation swelling, and auris dextra is used as control.After 4 hours, experimental animal is put to death, is cut
Lower two ears, auricle is laid with card punch at same position respectively, and the left and right ear of mouse is weighed, and inflammation is used as using its difference
Property swelling degree, calculate swelling suppress percentage.
(2), result of the test：As shown in table 3, present invention group and blank control group (P<0.01) with positive controls (P<
0.05) there is significant difference, Chinese medicine composition of the invention has obvious inhibitory action to croton oil induced mice ear swelling.
Influence of each group of table 3 to mice ear
| Group | Size of animal (only) | Dosage (g/kg) | Left ear swelling degree (mg) | Inhibiting rate (%) |
| Blank control group | 15 | 0 | 19.8±1.58 | 0 |
| Positive controls | 15 | 25.0 | 13.5±1.76 | 35.4% |
| Of the present invention group | 15 | 25.0 | 12.3±1.44 | 48.5% |
Test example 2：Model case
Model case 1：Xiao, man, 38 years old, main suit's left side waist and belly distending pain several months, Zuo Shen areas kowtowed pain, and CT examination finds left
Kidney has several pieces of calculus, and diameter the maximum 0.9cm, reckling 0.2cm are diagnosed as left kidney Calculus.Take the embodiment of the present application 1
Tablet in treatment, 2 tablets once, 3 times a day, and advise every daily drink 2000ml and do jumping more.After treatment 3 days, discharge is straight
5 pieces of footpath about 0.3cm calculus, continues after taking said medicine treatment 5 days, smoothly 3 pieces of discharge diameter about 0.8cm calculus, continues to take
Consolidated with 2 weeks.Patient's waist and belly pain symptom disappears, and check CT does not have found calculus light blocking shadow, with anti-1 year without recurrence.
Model case 2：Meng, female, 47 years old, main suit's urination was difficult, band blood in urine, and hospital diagnosis is kidney stone, operative treatment
Alleviate afterwards, but recurred and aggravate after 1 month.The tablet in treatment of the embodiment of the present application 1 is taken, 2 tablets once, 3 times a day, and
Advise every daily drink 2000ml and do jumping more.After treatment 7 days, frequent micturition and hematuria are significantly reduced, and urine is normal, continue to take
With 2 weeks, above-mentioned symptom was wholly absent, and calculus is had no through CT checks.
Model case 3：Mr. Wang, male, 51 years old, there is the not clear right lumbar region angina of reason in main suit before 2 months, after lying up
Spontaneous remission, ultrasound diagnosis finds that there are many pieces of calculus (4mm × 4mm) in right side kidney portion.The tablet in treatment of the embodiment of the present application 1 is taken,
2 tablets once, 3 times a day, and advise every daily drink 2000ml and do jumping more.Treat and checked after 3 weeks B ultrasound display right side kidney knot
Stone disappears.
Model case 4：Jiang, man, 23 years old, main suit had found ureteral calculi 2 years, abdomen pain slight pain during initial onset
Bitterly, there is cramp during breaking-out recently, the right kidney of ultrasound diagnosis and ureter there are many pieces of 8 × 6mm calculus.Take the application implementation
The tablet in treatment of example 1,2 tablets once, 3 times a day, and advise every daily drink 2000ml and do jumping more.B is checked after treating 3 weeks
Super display calculus is wholly absent.
Claims (4)
1. a kind of Chinese medicine composition for treating calculi in urinary system, it is characterised in that be made up of the Chinese medicine of following weight：
20 parts of Desmodium styracifolium, 20 parts of the membrane of a chicken's gizzard, extra large 20 parts of gold sand rattan, 25 parts of pyrrosia lingua, extra large 15 parts of gold sand, 15 parts of excrementum pteropi, 10 parts of Fructus Aurantii,
5 parts of 10 parts of dried orange peel, 15 parts of talcum powder and Radix Glycyrrhizae.
2. the preparation method of Chinese medicine composition as claimed in claim 1, it is characterised in that comprise the following steps：
A, Desmodium styracifolium, the membrane of a chicken's gizzard, extra large gold sand rattan, pyrrosia lingua, extra large gold sand, excrementum pteropi, Fructus Aurantii, dried orange peel, talcum powder and Radix Glycyrrhizae are weighed,
It is standby；
B, the membrane of a chicken's gizzard, extra large gold sand, talcum powder be crushed respectively after drying, and then cross 100-200 mesh sieves and obtain fine powder, it is standby；
C, will Desmodium styracifolium, extra large gold sand rattan, pyrrosia lingua, excrementum pteropi, Fructus Aurantii, dried orange peel and Radix Glycyrrhizae crush after mix, plus 6-10 times of volume
Decocting boil twice, first time 2-5 hour, second 0.5-3 hours, collecting decoction simultaneously retained filter residue, filtered decocting liquid, filtrate subtracts
It is standby that pressure is concentrated into the clear cream that 60 DEG C of relative densities are 1.12-1.18；
D, the 45-60% ethanol that step C filter residue is added to 4-8 times of volume, refluxing extraction 2 times are each 1-3 hours, filter, and merge
Filtrate, then vacuum distillation removes ethanol, and it is standby to be concentrated into the clear cream that 60 DEG C of relative densities are 1.12-1.18；
E, the clear cream merging by step C and step D, stir, and are heated to 50-80 DEG C and cross the filtration of 200-400 mesh sieves, filter while hot
Liquid is spray-dried, and produces spray powder, then adds step B fine powder, is crossed 100-200 mesh sieves and is well mixed, produces.
3. preparation method as claimed in claim 2, it is characterised in that step E spray drying condition is：Outlet temperature 80-
100 DEG C, 130-160 DEG C of inlet temperature, flow velocity 0.2-0.6kg/min, 23-30 DEG C of feed temperature.
4. purposes of the Chinese medicine composition as claimed in claim 1 in the medicine for preparing treatment calculi in urinary system.
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|---|---|---|---|---|
| CN102475777A (en) * | 2010-11-23 | 2012-05-30 | 鲜丹科 | Urolith elimination |
| CN104758702A (en) * | 2015-04-22 | 2015-07-08 | 李丽丽 | Liver soothing and bladder relieving agent for treating gallstone and preparation method of agent |
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| CN102475777A (en) * | 2010-11-23 | 2012-05-30 | 鲜丹科 | Urolith elimination |
| CN104758702A (en) * | 2015-04-22 | 2015-07-08 | 李丽丽 | Liver soothing and bladder relieving agent for treating gallstone and preparation method of agent |
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