CN103446445B - Traditional Chinese medicine preparation for treating qi-yin deficiency-type chronic bronchitis and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating qi-yin deficiency-type chronic bronchitis and a preparation method thereof. The traditional Chinese medicine preparation is prepared from the following medicinal raw materials: dwarf lilyturf tuber, prepared rehmannia root, white atractylodes rhizome, liquorice, poria cocos, tussilago farfara, common bletilla pseudobulb, ginkgo leaf, wild chrysanthemum flower, lily, companumoea root, passiflora henryi hemsl, radix glehniae, monotropa uniflora, crassifolia paraboea, polygonatum odoratum, chorion ovi, Chinese forgetmenot herb, Chinese pholidota herb, levant cotton root, elaeagnus conferta roxb, cudweed herb and helwingia root. The traditional Chinese medicine preparation has the beneficial effects that the traditional Chinese medicine preparation provided by the invention is based on China traditional Chinese medicine theory, has the effects of tonifying lung, benefiting qi, nourishing yin, engendering liquid, clearing way heat and toxic materials and relieving cough and asthma and a definite curative effect for treating the qi-yin deficiency-type chronic bronchitis with few side effects.

Description

Chinese medicine preparation for the treatment of type of deficiency of both QI and YIN chronic bronchitis and preparation method thereof

Technical field

The present invention relates to pharmaceutical technology, particularly a kind ofly treat Chinese medicine preparation of type of deficiency of both QI and YIN chronic bronchitis and preparation method thereof.

Background technology

Chronic bronchitis (chronic bronchitis) is trachea, the chronic nonspecific inflammation of bronchial mucosa and surrounding tissue thereof.Clinically with cough, expectoration or be cardinal symptom with asthma recurrent exerbation of etc.ing, lasting 3 months every year, continuous more than 2 years.Early symptom is slight, and more than winter attack, spring and summer is alleviated.Late period, symptom can exist throughout the year because of increased inflammation.Its Pathologic Characteristics is bronchus glandular hyperplasia and mucosa secretion increasing.The state of an illness is slow Progressive symmetric erythrokeratodermia progress, and Chang Bingfa obstructive emphysema, severe patient often pulmonary hypertension occurs, even pulmonary heart disease.

Current western medicine chronic bronchitis mainly adopts infection, the Therapeutic Method such as antitussive and antiasthmatic, though have certain curative effect for symptom management, relief of symptoms, cannot effect a radical cure, and easily causes bacterial drug resistance due to abuse of antibiotics, and treatment difficulty is strengthened.

Chronic bronchitis belongs to " cough ", " the syndrome of dyspnea ", " phlegm retention " category of the traditional Chinese medical science.Dirty closely related with lung, spleen, kidney three.Chronic bronchitis is mainly reflected as lung on pathogenesis, spleen, kidney three deficiency of five ZANG-organs damage, and their mutual relation is unbalance, simultaneously the more sophisticated because of the participation of the factors such as expectorant, fire, the stasis of blood again.Its basic pathogenesis is deficiency in origin and excess in superficiality.

The traditional Chinese medical science is particular about differentiation of symptoms and signs for classification of syndrome treatment, and Chinese medicine is divided into following four types by dialectical for chronic bronchitis: (1) external cold internal rheum type (2) damp and hot phlegm stagnancy type (3) type of deficiency of both QI and YIN (4) yang deficiency of spleen and stomache.And type of deficiency of both QI and YIN bronchitis is because gas the moon is all caused by void, cardinal symptom is: cough is breathed hard, and timidness and low voice, sound of cough being low and weak, coughs up phlegm thin or expectorant is few, restlessness and fever with thirst, discomfort in the throat, flushed face in the afternoon.Light red tongue or red tongue with exfoliative fur, thready and rapid pulse.Syndrome analysis: deficiency of the lung gas is become homeless master, insufficiency of lung-QI, therefore sees that cough is breathed hard, sound of cough being low and weak; Failure of qi transforming fluid, therefore it is thin to cough up phlegm; Lack of lung-YIN, hyperactivity of deficient fire, be then shown in cough few expectorant, restlessness and fever with thirst, discomfort in the throat, flushed face in the afternoon; Light red tongue or red tongue with exfoliative fur, thready and rapid pulse is levying of deficiency of both QI and YIN.Therefore, the bronchitic Therapeutic Principle of type of deficiency of both QI and YIN is invigorating the lung and benefiting vital QI, YIN nourishing and the production of body fluid promoting.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of and is used for the treatment of Chinese medicine preparation of type of deficiency of both QI and YIN chronic bronchitis and preparation method thereof, Chinese medicine preparation invigorating the lung and benefiting vital QI of the present invention, YIN nourishing and the production of body fluid promoting, heat-clearing and toxic substances removing, relieving cough and asthma, determined curative effect, side effect are little.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of type of deficiency of both QI and YIN chronic bronchitis, wherein, described Chinese medicine preparation comprises following raw medicinal material: Radix Ophiopogonis, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Poria, Flos Farfarae, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium Ginkgo, Flos Chrysanthemi Indici, Bulbus Lilii, Radix Campanumoeae, swallow tail, Radix Glehniae, Radix Monotropae Uniflorae, thick leaf Herba Boeae Hygrometricae, Rhizoma Polygonati Odorati, Membrana Follicularis ovi, Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis), Pseudobulbus Pholidotae Chinensis, Radix Gossypii, elaeagnus conferta fruits, Herba Gnaphalii Affinis and Radix Helwingiae.

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can be preferably as follows: Radix Ophiopogonis 20 ~ 40 parts, Radix Rehmanniae Preparata 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, 20 ~ 40 parts, Radix Glycyrrhizae, 15 ~ 25 parts, Poria, Flos Farfarae 20 ~ 40 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Folium Ginkgo 15 ~ 30 parts, Flos Chrysanthemi Indici 10 ~ 20 parts, Bulbus Lilii 25 ~ 40 parts, Radix Campanumoeae 20 ~ 40 parts, 15 ~ 30 parts, swallow tail, Radix Glehniae 15 ~ 30 parts, Radix Monotropae Uniflorae 5 ~ 15 parts, thick leaf Herba Boeae Hygrometricae 10 ~ 20 parts, Rhizoma Polygonati Odorati 15 ~ 30 parts, Membrana Follicularis ovi 20 ~ 40 parts, Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 10 ~ 20 parts, Pseudobulbus Pholidotae Chinensis 8 ~ 15 parts, Radix Gossypii 10 ~ 20 parts, elaeagnus conferta fruits 15 ~ 25 parts, Herba Gnaphalii Affinis 5 ~ 12 parts and 10 ~ 20 parts, Radix Helwingiae.

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can also be preferably as follows: Radix Ophiopogonis 30 ~ 40 parts, Radix Rehmanniae Preparata 10 ~ 15 parts, the Rhizoma Atractylodis Macrocephalae 15 ~ 20 parts, 25 ~ 35 parts, Radix Glycyrrhizae, 20 ~ 25 parts, Poria, Flos Farfarae 20 ~ 30 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 15 parts, Folium Ginkgo 20 ~ 30 parts, Flos Chrysanthemi Indici 10 ~ 15 parts, Bulbus Lilii 30 ~ 40 parts, Radix Campanumoeae 25 ~ 35 parts, 20 ~ 30 parts, swallow tail, Radix Glehniae 20 ~ 30 parts, Radix Monotropae Uniflorae 5 ~ 10 parts, thick leaf Herba Boeae Hygrometricae 10 ~ 15 parts, Rhizoma Polygonati Odorati 15 ~ 25 parts, Membrana Follicularis ovi 25 ~ 35 parts, Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 10 ~ 15 parts, Pseudobulbus Pholidotae Chinensis 8 ~ 12 parts, Radix Gossypii 15 ~ 20 parts, elaeagnus conferta fruits 20 ~ 25 parts, Herba Gnaphalii Affinis 5 ~ 8 parts and 10 ~ 15 parts, Radix Helwingiae.

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can be preferably as follows again: Radix Ophiopogonis 35 parts, Radix Rehmanniae Preparata 12 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, 28 parts, Radix Glycyrrhizae, 23 parts, Poria, Flos Farfarae 27 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 13 parts, Folium Ginkgo 22 parts, Flos Chrysanthemi Indici 14 parts, Bulbus Lilii 35 parts, Radix Campanumoeae 31 parts, 22 parts, swallow tail, Radix Glehniae 24 parts, Radix Monotropae Uniflorae 7 parts, thick leaf Herba Boeae Hygrometricae 11 parts, Rhizoma Polygonati Odorati 20 parts, Membrana Follicularis ovi 29 parts, Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 12 parts, Pseudobulbus Pholidotae Chinensis 9 parts, Radix Gossypii 17 parts, elaeagnus conferta fruits 23 parts, Herba Gnaphalii Affinis 7 parts and 14 parts, Radix Helwingiae.

Wherein, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:

The first step, by Radix Campanumoeae, swallow tail, Radix Glehniae, Radix Monotropae Uniflorae, thick leaf Herba Boeae Hygrometricae, Rhizoma Polygonati Odorati and Membrana Follicularis ovi mix in described ratio, are the dissolve with ethanol of 90% ~ 95% with the determining alcohol of 6 ~ 8 times relative to the mixture quality obtained, reflux is extracted for 4 ~ 6 hours, filters, obtains the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 80% ~ 85% of 3 ~ 5 times relative to the mixture quality obtained, reflux is extracted for 2 ~ 4 hours, filters, obtains the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.1 ~ 1.3g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 10 times of resin column volumes, be 70% ~ 75% ethanol elution with the determining alcohol of 6 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis), Pseudobulbus Pholidotae Chinensis, Radix Gossypii, elaeagnus conferta fruits, Herba Gnaphalii Affinis and Radix Helwingiae mix in described ratio, add the ethanol of the determining alcohol 90% ~ 95% of 8 ~ 10 times relative to the mixture quality obtained, heating and refluxing extraction 3 ~ 5 times, each time extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C ~ 80 DEG C 70 DEG C, relative density is the mastic of 1.32 ~ 1.34, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water of 6 ~ 10 times relative to the mixture quality obtained, and soaks 12-18 hour, and heating decoction 5 ~ 8 hours, filters; By filtering residue again with the water of 4 ~ 6 times relative to the mixture quality obtained, heating decoction 3 ~ 4 hours, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, be crushed and screened into 200 ~ 300 object fine powders subsequently, add starch, the percentage by weight of described starch in described powder is 25% ~ 35%, drops in mixing and blending machine and stirs, namely obtain described Chinese powder medicine, by the Chinese powder medicine pouch after mixing or packing box subpackage, every 8 ~ 15 grams is one bag or a box subpackage.

Wherein, when the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:

The first step, by Radix Campanumoeae, swallow tail, Radix Glehniae, Radix Monotropae Uniflorae, thick leaf Herba Boeae Hygrometricae, Rhizoma Polygonati Odorati and Membrana Follicularis ovi mix in described ratio, add the water extraction volatile oil relative to 5 ~ 10 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1:4 ~ 8, stir 100 minutes ~ 150 minutes, temperature 45 C ~ 60 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 70 DEG C relative density be the clear paste of 1.31 ~ 1.33;

Second step, by Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis), Pseudobulbus Pholidotae Chinensis, Radix Gossypii, elaeagnus conferta fruits, Herba Gnaphalii Affinis and Radix Helwingiae mix in described ratio, add relative to mixture 6 ~ 10 times amount determining alcohol be 90% ~ 95% alcohol reflux 3 ~ 5 times, each 2 ~ 4 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 70 DEG C, relative density is the clear paste of 1.34 ~ 1.36, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 5 ~ 7 times of water gagings, boil 3 ~ 5 hours, filter, and when being concentrated into 70 DEG C, relative density is the clear paste of 1.36 ~ 1.38;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 75 DEG C ~ 80 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 ~ 10 weight portion carboxymethyl starch sodium, 15 ~ 20 weight starch mix homogeneously, adding 120 ~ 150 weight portion determining alcohols is again 80% ~ 90% alcohol granulation, dry, granulate, subsequently again relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 10 ~ 15 weight portion magnesium stearate, then load in gelatine capsule.

Beneficial effect of the present invention: the theory of Chinese medical science that Chinese medicine preparation provided by the invention utilizes China traditional, invigorating the lung and benefiting vital QI, YIN nourishing and the production of body fluid promoting, heat-clearing and toxic substances removing, relieving cough and asthma, treatment type of deficiency of both QI and YIN chronic bronchitis determined curative effect, side effect is little.

Detailed description of the invention

The invention provides a kind of Chinese medicine preparation for the treatment of type of deficiency of both QI and YIN chronic bronchitis, wherein, described Chinese medicine preparation comprises following raw medicinal material: Radix Ophiopogonis, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Poria, Flos Farfarae, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium Ginkgo, Flos Chrysanthemi Indici, Bulbus Lilii, Radix Campanumoeae, swallow tail, Radix Glehniae, Radix Monotropae Uniflorae, thick leaf Herba Boeae Hygrometricae, Rhizoma Polygonati Odorati, Membrana Follicularis ovi, Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis), Pseudobulbus Pholidotae Chinensis, Radix Gossypii, elaeagnus conferta fruits, Herba Gnaphalii Affinis and Radix Helwingiae.

In described Chinese medicine preparation, the pharmacology of each raw medicinal material is as follows:

Radix Ophiopogonis: sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease is coughed, and Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.

Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.Nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.

The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.

Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Poria: sweet, light is flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Flos Farfarae: pungent, micro-hardship, temperature.Return lung meridian.Nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm.Cough for new chronic cough, dyspnea and cough with excessive sputum, chronic cough hemoptysis.

Pseudobulbus Bletillae (Rhizoma Bletillae): bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.

Folium Ginkgo: sweet, bitter, puckery is flat.GUIXIN, lung meridian.Astringe the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving.For cough and asthma due to lung deficiency; Coronary heart disease, angina pectoris, hyperlipidemia.

Flos Chrysanthemi Indici: bitter, pungent, is slightly cold.Return liver, heart channel.Heat-clearing and toxic substances removing.For furuncle carbuncle, conjunctival congestion and swelling pain, has a headache dizzy.

Bulbus Lilii: sweet, cold.GUIXIN, lung meridian.Nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.

Radix Campanumoeae: sweet in the mouth, micro-hardship, warm in nature.Strengthening the spleen and stomach, tonifying the lung gas, expelling phlegm for arresting cough.Control asthenia internal injury, cough due to deficiency of the lung, diarrhea due to hypofunction of the spleen, milk is few, infantile malnutrition, the enuresis." Guizhou side's medicine among the people collection ": tonify deficiency QI invigorating, expelling phlegm for arresting cough.

Swallow tail: bitter, micro-sweet, temperature.Invigorating the lung and benefiting vital QI, antiinflammatory, sterilization.Cure mainly dysentery, pulmonary tuberculosis, bronchitis.

Radix Glehniae: cold nature, sweet in the mouth, micro-hardship.Enter lung, spleen channel.Nourishing YIN and clearing away lung-heat, expelling phlegm for arresting cough.Control lung-heat type cough, chronic consumptive disease chronic cough, the moon hinders dry pharynx, thirsty." Bencao Congxin ": specially tonifying the lung is cloudy, lung heat clearing fire, controls chronic cough consumptive lung disease." will planted by northeast medicine ": control chronic bronchitis, pulmonary tuberculosis, pulmonary atelectasis, lung abscess etc." Chinese medicinal herbal ": support lung yin, clearing away lung-heat, expelling phlegm for arresting cough.Control deficient fever, the moon hinders cough caused by dryness, thirsty and dry pharynx.

Radix Monotropae Uniflorae: sweet, property is put down.Tonifying the lung and stopping cough.Main cough due to deficiency of the lung.

Thick leaf Herba Boeae Hygrometricae: sweet in the mouth, property is put down.Tonifying the lung and stopping cough, cooling blood for hemostasis.Main cough and asthma due to lung deficiency, spitting of blood, metrorrhagia." Xinhua's book on Chinese herbal medicine outline ": herb: sweet in the mouth, property are flat.There is strengthening by means of tonics, the function of hemostasis, cough-relieving.For treating the liver insufficiency of the spleen weak, over-strained hemoptysis, internal injury spitting of blood, pneumonopathy cough with asthma, leucorrhea, innominate toxic swelling etc.

Rhizoma Polygonati Odorati: sweet in the mouth, is slightly cold, and property is put down.Return lung; Stomach warp.Nourishing YIN and moistening the lung, promoting the production of body fluid to quench thirst.Main cough caused by dryness, chronic cough, the dry throat and mouth of calentura cloudy liquid consumption wound, interior-heat is quenched one's thirst, deficiency of YIN diseases caused by exogenous pathogenic factor, dizzy dizzy, muscle arteries and veins spasm and pain." Guangxi Chinese medicinal herbal ": nourishing YIN and clearing away lung-heat is moisturized.Control the deficiency of YIN, hyperhidrosis, cough caused by dryness, consumptive lung disease.

Membrana Follicularis ovi: sweet, temperature.Return spleen, stomach, lung meridian.Tonifying the lung and stopping cough.For chronic tracheitis, chronic cough, night sweat." Zhejiang Chinese medicine handbook ": lung heat clearing fire, dryness-transformation expectorant.Control pharyngalgia aphonia.

Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis): bitter, cool.Return lung, liver, kidney channel.Removing heat from the lung and dissipating phlegm, hemostasis.Control cough, spit blood, scrofula, knife injury." Tian Bao book on Chinese herbal medicine ": clearing away lung-heat to relieve cough reduces phlegm, controls gas fire scrofula.Chengdu " conventional herbtherapy handbook ": nourishing YIN and moistening the lung, clearing and antitussive.Control pulmonary tuberculosis cough, aphonia, lyssodexis.

Pseudobulbus Pholidotae Chinensis: sweet, bitter, light, cool.Enter lung, liver two warp.Nourishing the lung to arrest cough, blood-activating analgetic.For pulmonary tuberculosis cough, cough with asthma QI rising in reverse order person.

Radix Gossypii: sweet in the mouth, warm in nature.Return lung, spleen, Liver Channel.Relieving cough and asthma, inducing menstruation to relieve menalgia.Main cough, asthma, has through uncomfortable, metrorrhagia.

Elaeagnus conferta fruits: acid is flat.Relieving cough and asthma, astringing to arrest diarrhea.Cure mainly asthma, void is coughed, chronic bronchitis, enteritis, diarrhoea, treating swelling and pain by traumatic injury, rheumatalgia, jaundice.Also haematemesis can be controlled, spitting of blood, laryngopharynx swelling and pain, flu, infantile convulsion, the diseases such as skin ulcer tinea.

Herba Gnaphalii Affinis: sweet is flat.Relieving cough and asthma, blood pressure lowering, wind-damp dispelling, eliminates the phlegm.For cold cough, bronchitis, asthma, hypertension, favism, lumbago, skelalgia of rheumatism, phlegm dyspnea, rheumatic arthralgia; Traumatic injury is controlled in external, venom.

Radix Helwingiae: bitter, pungent is flat.Antiasthmatic-antitussive, blood circulation promoting and blood stasis dispelling.Control cough with asthma, rheumatism, impairment caused by overstrain, menoxenia, traumatic injury." Guizhou medical herbs ": tonify deficiency, cough-relieving, pain relieving, Gu de-.

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can be preferably as follows: Radix Ophiopogonis 20 ~ 40 parts, Radix Rehmanniae Preparata 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, 20 ~ 40 parts, Radix Glycyrrhizae, 15 ~ 25 parts, Poria, Flos Farfarae 20 ~ 40 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Folium Ginkgo 15 ~ 30 parts, Flos Chrysanthemi Indici 10 ~ 20 parts, Bulbus Lilii 25 ~ 40 parts, Radix Campanumoeae 20 ~ 40 parts, 15 ~ 30 parts, swallow tail, Radix Glehniae 15 ~ 30 parts, Radix Monotropae Uniflorae 5 ~ 15 parts, thick leaf Herba Boeae Hygrometricae 10 ~ 20 parts, Rhizoma Polygonati Odorati 15 ~ 30 parts, Membrana Follicularis ovi 20 ~ 40 parts, Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 10 ~ 20 parts, Pseudobulbus Pholidotae Chinensis 8 ~ 15 parts, Radix Gossypii 10 ~ 20 parts, elaeagnus conferta fruits 15 ~ 25 parts, Herba Gnaphalii Affinis 5 ~ 12 parts and 10 ~ 20 parts, Radix Helwingiae.

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can also be preferably as follows: Radix Ophiopogonis 30 ~ 40 parts, Radix Rehmanniae Preparata 10 ~ 15 parts, the Rhizoma Atractylodis Macrocephalae 15 ~ 20 parts, 25 ~ 35 parts, Radix Glycyrrhizae, 20 ~ 25 parts, Poria, Flos Farfarae 20 ~ 30 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 15 parts, Folium Ginkgo 20 ~ 30 parts, Flos Chrysanthemi Indici 10 ~ 15 parts, Bulbus Lilii 30 ~ 40 parts, Radix Campanumoeae 25 ~ 35 parts, 20 ~ 30 parts, swallow tail, Radix Glehniae 20 ~ 30 parts, Radix Monotropae Uniflorae 5 ~ 10 parts, thick leaf Herba Boeae Hygrometricae 10 ~ 15 parts, Rhizoma Polygonati Odorati 15 ~ 25 parts, Membrana Follicularis ovi 25 ~ 35 parts, Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 10 ~ 15 parts, Pseudobulbus Pholidotae Chinensis 8 ~ 12 parts, Radix Gossypii 15 ~ 20 parts, elaeagnus conferta fruits 20 ~ 25 parts, Herba Gnaphalii Affinis 5 ~ 8 parts and 10 ~ 15 parts, Radix Helwingiae.

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can be preferably as follows again: Radix Ophiopogonis 35 parts, Radix Rehmanniae Preparata 12 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, 28 parts, Radix Glycyrrhizae, 23 parts, Poria, Flos Farfarae 27 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 13 parts, Folium Ginkgo 22 parts, Flos Chrysanthemi Indici 14 parts, Bulbus Lilii 35 parts, Radix Campanumoeae 31 parts, 22 parts, swallow tail, Radix Glehniae 24 parts, Radix Monotropae Uniflorae 7 parts, thick leaf Herba Boeae Hygrometricae 11 parts, Rhizoma Polygonati Odorati 20 parts, Membrana Follicularis ovi 29 parts, Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 12 parts, Pseudobulbus Pholidotae Chinensis 9 parts, Radix Gossypii 17 parts, elaeagnus conferta fruits 23 parts, Herba Gnaphalii Affinis 7 parts and 14 parts, Radix Helwingiae.

Wherein, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:

The first step, by Radix Campanumoeae, swallow tail, Radix Glehniae, Radix Monotropae Uniflorae, thick leaf Herba Boeae Hygrometricae, Rhizoma Polygonati Odorati and Membrana Follicularis ovi mix in described ratio, are the dissolve with ethanol of 90% ~ 95% with the determining alcohol of 6 ~ 8 times relative to the mixture quality obtained, reflux is extracted for 4 ~ 6 hours, filters, obtains the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 80% ~ 85% of 3 ~ 5 times relative to the mixture quality obtained, reflux is extracted for 2 ~ 4 hours, filters, obtains the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.1 ~ 1.3g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 10 times of resin column volumes, be 70% ~ 75% ethanol elution with the determining alcohol of 6 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis), Pseudobulbus Pholidotae Chinensis, Radix Gossypii, elaeagnus conferta fruits, Herba Gnaphalii Affinis and Radix Helwingiae mix in described ratio, add the ethanol of the determining alcohol 90% ~ 95% of 8 ~ 10 times relative to the mixture quality obtained, heating and refluxing extraction 3 ~ 5 times, each time extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C ~ 80 DEG C 70 DEG C, relative density is the mastic of 1.32 ~ 1.34, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water of 6 ~ 10 times relative to the mixture quality obtained, and soaks 12-18 hour, and heating decoction 5 ~ 8 hours, filters; By filtering residue again with the water of 4 ~ 6 times relative to the mixture quality obtained, heating decoction 3 ~ 4 hours, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, be crushed and screened into 200 ~ 300 object fine powders subsequently, add starch, the percentage by weight of described starch in described powder is 25% ~ 35%, drops in mixing and blending machine and stirs, namely obtain described Chinese powder medicine, by the Chinese powder medicine pouch after mixing or packing box subpackage, every 8 ~ 15 grams is one bag or a box subpackage.

Wherein, when the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:

The first step, by Radix Campanumoeae, swallow tail, Radix Glehniae, Radix Monotropae Uniflorae, thick leaf Herba Boeae Hygrometricae, Rhizoma Polygonati Odorati and Membrana Follicularis ovi mix in described ratio, add the water extraction volatile oil relative to 5 ~ 10 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1:4 ~ 8, stir 100 minutes ~ 150 minutes, temperature 45 C ~ 60 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 70 DEG C relative density be the clear paste of 1.31 ~ 1.33;

Second step, by Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis), Pseudobulbus Pholidotae Chinensis, Radix Gossypii, elaeagnus conferta fruits, Herba Gnaphalii Affinis and Radix Helwingiae mix in described ratio, add relative to mixture 6 ~ 10 times amount determining alcohol be 90% ~ 95% alcohol reflux 3 ~ 5 times, each 2 ~ 4 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 70 DEG C, relative density is the clear paste of 1.34 ~ 1.36, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 5 ~ 7 times of water gagings, boil 3 ~ 5 hours, filter, and when being concentrated into 70 DEG C, relative density is the clear paste of 1.36 ~ 1.38;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 75 DEG C ~ 80 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 ~ 10 weight portion carboxymethyl starch sodium, 15 ~ 20 weight starch mix homogeneously, adding 120 ~ 150 weight portion determining alcohols is again 80% ~ 90% alcohol granulation, dry, granulate, subsequently again relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 10 ~ 15 weight portion magnesium stearate, then load in gelatine capsule.

Below adopt example to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Powder prepared by embodiment 1 the present invention

Get 350g Radix Ophiopogonis, Radix Rehmanniae Preparata 120g, Rhizoma Atractylodis Macrocephalae 180g, Radix Glycyrrhizae 280g, Poria 230g, Flos Farfarae 270g, Pseudobulbus Bletillae (Rhizoma Bletillae) 130g, Folium Ginkgo 220g, Flos Chrysanthemi Indici 140g, Bulbus Lilii 350g, Radix Campanumoeae 310g, swallow tail 220g, Radix Glehniae 240g, Radix Monotropae Uniflorae 70g, thick leaf Herba Boeae Hygrometricae 110g, Rhizoma Polygonati Odorati 200g, Membrana Follicularis ovi 290g, Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 120g, Pseudobulbus Pholidotae Chinensis 90g, Radix Gossypii 170g, elaeagnus conferta fruits 230g, Herba Gnaphalii Affinis 70g and Radix Helwingiae 140g;

Its preparation method comprises the following steps:

The first step, by Radix Campanumoeae, swallow tail, Radix Glehniae, Radix Monotropae Uniflorae, thick leaf Herba Boeae Hygrometricae, Rhizoma Polygonati Odorati and Membrana Follicularis ovi mix in described ratio, are the dissolve with ethanol of 95% with the determining alcohol of 7 times relative to the mixture quality obtained, reflux is extracted for 5 hours, filters, obtains the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 80% of 5 times relative to the mixture quality obtained, reflux is extracted for 4 hours, filters, obtains the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.2g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 10 times of resin column volumes, be 75% ethanol elution with the determining alcohol of 6 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis), Pseudobulbus Pholidotae Chinensis, Radix Gossypii, elaeagnus conferta fruits, Herba Gnaphalii Affinis and Radix Helwingiae mix in described ratio, add the ethanol of the determining alcohol 90% of 9 times relative to the mixture quality obtained, heating and refluxing extraction 5 times, each time extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 80 DEG C 70 DEG C, relative density is the mastic of 1.34, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water of 9 times relative to the mixture quality obtained, soaks 15 hours, and heating decoction 7 hours, filters; By filtering residue again with the water of 5 times relative to the mixture quality obtained, heating decoction 3 hours, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, be crushed and screened into 300 object fine powders subsequently, add starch, the percentage by weight of starch in powder is 30%, drops in mixing and blending machine and stirs, namely obtain described Chinese powder medicine, by the Chinese powder medicine pouch after mixing or packing box subpackage, every 12 grams is one bag of subpackage.

Capsule prepared by embodiment 2 the present invention

Get 320g Radix Ophiopogonis, Radix Rehmanniae Preparata 140g, Rhizoma Atractylodis Macrocephalae 160g, Radix Glycyrrhizae 340g, Poria 210g, Flos Farfarae 240g, Pseudobulbus Bletillae (Rhizoma Bletillae) 110g, Folium Ginkgo 280g, Flos Chrysanthemi Indici 110g, Bulbus Lilii 390g, Radix Campanumoeae 340g, swallow tail 270g, Radix Glehniae 280g, Radix Monotropae Uniflorae 90g, thick leaf Herba Boeae Hygrometricae 130g, Rhizoma Polygonati Odorati 170g, Membrana Follicularis ovi 330g, Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 140g, Pseudobulbus Pholidotae Chinensis 110g, Radix Gossypii 150g, elaeagnus conferta fruits 210g, Herba Gnaphalii Affinis 60g and Radix Helwingiae 120g;

Its preparation method comprises the following steps:

The first step, by Radix Campanumoeae, swallow tail, Radix Glehniae, Radix Monotropae Uniflorae, thick leaf Herba Boeae Hygrometricae, Rhizoma Polygonati Odorati and Membrana Follicularis ovi mix in described ratio, add the water extraction volatile oil relative to 7 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1:7, stir 130 minutes, temperature 50 C, obtains volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 70 DEG C relative density be the clear paste of 1.33;

Second step, by Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis), Pseudobulbus Pholidotae Chinensis, Radix Gossypii, elaeagnus conferta fruits, Herba Gnaphalii Affinis and Radix Helwingiae mix in described ratio, add relative to mixture 10 times amount determining alcohol be 90% alcohol reflux 5 times, each 3 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 70 DEG C, relative density is the clear paste of 1.35, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 6 times of water gagings, boil 4 hours, filter, and when being concentrated into 70 DEG C, relative density is the clear paste of 1.37;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 80 DEG C of reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 9 weight portion carboxymethyl starch sodium, 19 weight starch mix homogeneously, then to add 135 weight portion determining alcohols be 85% alcohol granulation, dry, granulate, subsequently again relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 13 weight portion magnesium stearate, then load in gelatine capsule.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 24 ~ 30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese powder medicine prepared by embodiments of the invention 1, (concentration is 4.28g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 21.4 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet of the present invention and LD50 > 21.4 crude drugs/kg, every day, maximum dosage-feeding was 42.8 crude drugs/kg/ day.Chinese medicine preparation clinical application amount of the present invention be 4.8g crude drug/day/people, adult body weight in 60KG, average dosage is 0.08g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 27g) oral administration gavage Chinese medicine preparation of the present invention is 535 times of quantity.Therefore Chinese medicine preparation acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: application rat 30, male and female half and half, body weight 220 ~ 260g, carries out long term toxicity test.Powder prepared by the embodiment of the present invention 1 to rat by 16.15,24.16 and 47.23g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and each internal organs of rat are all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data

Case selection: whole 60 routine cases are my Out-patient Department patient in August, 2009 ~ in June, 2012.Be divided into treatment group and matched group at random, wherein treatment group 30 people, male 12 people, women 18 people, 30 ~ 69 years old age; Matched group 30 people, male 10 people, women 20 people, 32 ~ 65 years old age.Two groups in age, sex, clinical manifestation etc. through statistical analysis there was no significant difference (p > 0.05).

Diagnostic criteria: cough, expectoration or companion pant, annual morbidity continue 3 months continuous more than 2 years, and get rid of other heart, lung disease (pulmonary tuberculosis, pneumoconiosis, bronchial asthma, bronchiectasis, pulmonary carcinoma, heart disease, cardiac insufficiency), and breathe hard with cough, timidness and low voice, sound of cough being low and weak, expectoration is thin or expectorant is few, restlessness and fever with thirst, discomfort in the throat, flushed face in the afternoon, light red tongue or red tongue with thin fur, thready and rapid pulse.

Therapeutic Method: treatment group: take Chinese medicine preparation embodiment 1 powder of the present invention, each 1 bag, every day 3 times 30 days was 1 course for the treatment of.

Matched group: each 0.25 ~ 0.5g of oral cefalexin, every day 3 times; Each 0.3 ~ the 0.5g of oral ammonium chloride, every day 3 times; Each 0.1 ~ the 0.2g of aminophylline, every day 3 times.It within 30 days, was 1 course for the treatment of.

Symptom curative effect judging standard: cure: cough and clinical symptom disappearance, endogenous cough did not show effect more than two weeks.Effective: cough alleviates, amount of expectoration reduces.Invalid: clinical symptoms is without change.

Therapeutic outcome: treat 1 course for the treatment of respectively for two groups, curative effect statistics is as following table.

	n	Cure	Effectively	Invalid	Cure rate	Total effective rate
							Treatment group	30	24	6	0	24(80％)	15(100％)
Matched group	30	13	9	8	12(43.33％)	22(73.33％)

Known by upper table, treatment group cure rate and the effective percentage of taking Chinese medicine preparation of the present invention are all high than matched group, for the treatment of type of deficiency of both QI and YIN chronic bronchitis, have determined curative effect, rapid-action, the advantage that side effect is little.

Model case: Luo, female, 42 years old, cough was breathed hard, sound of cough being low and weak, and expectoration is thin or expectorant is few, restlessness and fever with thirst, discomfort in the throat, flushed face in the afternoon, red tongue with thin fur, thready and rapid pulse; By auscultation, the situation of heart is: do not hear and obvious pathologic murmur, heart rate 70 beats/min, heart rate is neat.The situation of lung is: do not hear and dry, moist rales, wheezing sound is not obvious, and bottom right lung is even has respiratory coarse.It is thick that chest x-ray shows that two lung bottom textures increase.Be diagnosed as type of deficiency of both QI and YIN chronic bronchitis.Take Chinese medicine preparation embodiment 1 powder of the present invention 20 days, be almost recovered, fully recover after continuing to take 10 days, follow up a case by regular visits to and do not recur for 1 year half.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (3)

1. treat the Chinese medicine preparation of type of deficiency of both QI and YIN chronic bronchitis, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is as follows: Radix Ophiopogonis 20 ~ 40 parts, Radix Rehmanniae Preparata 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, 20 ~ 40 parts, Radix Glycyrrhizae, 15 ~ 25 parts, Poria, Flos Farfarae 20 ~ 40 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Folium Ginkgo 15 ~ 30 parts, Flos Chrysanthemi Indici 10 ~ 20 parts, Bulbus Lilii 25 ~ 40 parts, Radix Campanumoeae 20 ~ 40 parts, 15 ~ 30 parts, swallow tail, Radix Glehniae 15 ~ 30 parts, Radix Monotropae Uniflorae 5 ~ 15 parts, thick leaf Herba Boeae Hygrometricae 10 ~ 20 parts, Rhizoma Polygonati Odorati 15 ~ 30 parts, Membrana Follicularis ovi 20 ~ 40 parts, Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 10 ~ 20 parts, Pseudobulbus Pholidotae Chinensis 8 ~ 15 parts, Radix Gossypii 10 ~ 20 parts, elaeagnus conferta fruits 15 ~ 25 parts, Herba Gnaphalii Affinis 5 ~ 12 parts and 10 ~ 20 parts, Radix Helwingiae,

The dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

The first step, by Radix Campanumoeae, swallow tail, Radix Glehniae, Radix Monotropae Uniflorae, thick leaf Herba Boeae Hygrometricae, Rhizoma Polygonati Odorati and Membrana Follicularis ovi mix in described ratio, are the dissolve with ethanol of 90% ~ 95% with the determining alcohol of 6 ~ 8 times relative to the mixture quality obtained, reflux is extracted for 4 ~ 6 hours, filters, obtains the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 80% ~ 85% of 3 ~ 5 times relative to the mixture quality obtained, reflux is extracted for 2 ~ 4 hours, filters, obtains the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.1 ~ 1.3g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 10 times of resin column volumes, be 70% ~ 75% ethanol elution with the determining alcohol of 6 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis), Pseudobulbus Pholidotae Chinensis, Radix Gossypii, elaeagnus conferta fruits, Herba Gnaphalii Affinis and Radix Helwingiae mix in described ratio, add the ethanol of the determining alcohol 90% ~ 95% of 8 ~ 10 times relative to the mixture quality obtained, heating and refluxing extraction 3 ~ 5 times, each time extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C ~ 80 DEG C 70 DEG C, relative density is the mastic of 1.32 ~ 1.34, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water of 6 ~ 10 times relative to the mixture quality obtained, and soaks 12-18 hour, and heating decoction 5 ~ 8 hours, filters; By filtering residue again with the water of 4 ~ 6 times relative to the mixture quality obtained, heating decoction 3 ~ 4 hours, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, be crushed and screened into 200 ~ 300 object fine powders subsequently, add starch, the percentage by weight of described starch in described powder is 25% ~ 35%, drops in mixing and blending machine and stirs, namely obtain described Chinese powder medicine, by the Chinese powder medicine pouch after mixing or packing box subpackage, every 8 ~ 15 grams is one bag or a box subpackage.

2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is as follows: Radix Ophiopogonis 30 ~ 40 parts, Radix Rehmanniae Preparata 10 ~ 15 parts, the Rhizoma Atractylodis Macrocephalae 15 ~ 20 parts, 25 ~ 35 parts, Radix Glycyrrhizae, 20 ~ 25 parts, Poria, Flos Farfarae 20 ~ 30 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 15 parts, Folium Ginkgo 20 ~ 30 parts, Flos Chrysanthemi Indici 10 ~ 15 parts, Bulbus Lilii 30 ~ 40 parts, Radix Campanumoeae 25 ~ 35 parts, 20 ~ 30 parts, swallow tail, Radix Glehniae 20 ~ 30 parts, Radix Monotropae Uniflorae 5 ~ 10 parts, thick leaf Herba Boeae Hygrometricae 10 ~ 15 parts, Rhizoma Polygonati Odorati 15 ~ 25 parts, Membrana Follicularis ovi 25 ~ 35 parts, Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 10 ~ 15 parts, Pseudobulbus Pholidotae Chinensis 8 ~ 12 parts, Radix Gossypii 15 ~ 20 parts, elaeagnus conferta fruits 20 ~ 25 parts, Herba Gnaphalii Affinis 5 ~ 8 parts and 10 ~ 15 parts, Radix Helwingiae.

3. Chinese medicine preparation as claimed in claim 1, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is as follows: Radix Ophiopogonis 35 parts, Radix Rehmanniae Preparata 12 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, 28 parts, Radix Glycyrrhizae, 23 parts, Poria, Flos Farfarae 27 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 13 parts, Folium Ginkgo 22 parts, Flos Chrysanthemi Indici 14 parts, Bulbus Lilii 35 parts, Radix Campanumoeae 31 parts, 22 parts, swallow tail, Radix Glehniae 24 parts, Radix Monotropae Uniflorae 7 parts, thick leaf Herba Boeae Hygrometricae 11 parts, Rhizoma Polygonati Odorati 20 parts, Membrana Follicularis ovi 29 parts, Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 12 parts, Pseudobulbus Pholidotae Chinensis 9 parts, Radix Gossypii 17 parts, elaeagnus conferta fruits 23 parts, Herba Gnaphalii Affinis 7 parts and 14 parts, Radix Helwingiae.