CN114099590B

CN114099590B - Fermented Chinese herbal medicine preparation for preventing and treating diarrhea of livestock and poultry and preparation method thereof

Info

Publication number: CN114099590B
Application number: CN202111288475.1A
Authority: CN
Inventors: 张吉鹍; 肖军平; 刘志富; 陈梁; 邵智军; 赖贻圶; 胡厚平; 朱斌; 尧国荣; 吴晓林; 李检香; 李龙瑞
Original assignee: JIANGXI PUZHENG PHARMACEUTICAL CO Ltd; JIANGXI XINTIANDI PHARMACEUTICAL CO Ltd
Current assignee: JIANGXI PUZHENG PHARMACEUTICAL CO Ltd; JIANGXI XINTIANDI PHARMACEUTICAL CO Ltd
Priority date: 2021-11-02
Filing date: 2021-11-02
Publication date: 2023-07-04
Anticipated expiration: 2041-11-02
Also published as: CN114099590A

Abstract

The invention relates to the technical field of Chinese herbal medicines for livestock and poultry, in particular to a fermented Chinese herbal medicine preparation for preventing and treating diarrhea of livestock and poultry and a preparation method thereof. The fermented Chinese herbal medicine preparation comprises the following components in percentage by weight: 55-65% of Chinese herbal medicine mixture and 35-45% of yeast culture, wherein the Chinese herbal medicine mixture comprises white paeony root, beautyberry, dried orange peel, largehead atractylodes rhizome, climbing groundsel herb and divaricate saposhnikovia root. The invention has the advantages of good curative effect, quick response, convenient use, simple production process and no toxic or side effect.

Description

Fermented Chinese herbal medicine preparation for preventing and treating diarrhea of livestock and poultry and preparation method thereof

Technical Field

The invention relates to the technical field of Chinese herbal medicines for livestock and poultry, in particular to a fermented Chinese herbal medicine preparation for preventing and treating diarrhea of livestock and poultry and a preparation method thereof.

Background

In recent years, the breeding scale of livestock is continuously enlarged, but the problem of diarrhea of livestock in breeding production always plagues farmers, and the problem of diarrhea affects the health state of livestock, so that the livestock grows slowly, the feed conversion rate is reduced, various diseases are even caused, the economic benefit of a large-scale livestock farm is seriously affected, and great economic loss is caused.

Diarrhea in livestock is caused by a variety of reasons, which are summarized as disease diarrhea and environmental diarrhea. Diseases caused by various pathogenic bacteria such as Escherichia coli, salmonella, paratyphoid, etc. can cause diarrhea in livestock. Diseases caused by various viruses such as newcastle disease virus, avian influenza virus, etc. can cause diarrhea in livestock. Moreover, diarrhea also often plays a significant role in diagnosing disease as a concurrent symptom.

Climate diarrhea refers to severe changes in the feeding environment, resulting in stronger stress reactions in livestock and poultry, and diarrhea. When the health and safety of feed (such as feeding soybean meal, moldy feed and the like) and drinking water (the water source is polluted and the like) are problematic, the digestive system of livestock can be disturbed, and diarrhea is caused.

The main cause of diarrhea in livestock and poultry is as follows: viral diarrhea; bacterial diarrhea; thirdly, parasitic diarrhea; fourthly, nutritional and metabolic diarrhea; fifth, environmental stress diarrhea; and sixth, compensatory diarrhea, etc. The main symptoms are as follows: the feces are watery or pasty, grey, yellow to white, and occasionally brown, yellow brown or white in shape due to occult blood, with blood streaks or purulent blood, fishy smell, emaciation, poor hair color, rough and messy hair, poor growth, mental wilt, abdominal pain, urgent back and heavy, and inappetence.

The diarrhea of livestock and poultry is syndrome caused by enterotoxin which is characterized by diarrhea of livestock and poultry and is caused by various pathogenic factors, and the current medicines for preventing and treating the diarrhea of livestock and poultry are mostly western medicine preparations, traditional Chinese medicine powder and traditional Chinese medicine powder, mainly aiming at bacterial diarrhea, and the traditional Chinese medicine powder has a certain effect but also has great side effect.

The Chinese patent application CN201610901370.1 discloses a traditional Chinese medicine composition for preventing and treating diarrhea of livestock and poultry, which comprises the following components in parts by weight: 4-8 parts of mulberry, 6-8 parts of medlar, 3-5 parts of poria cocos, 1-3 parts of liquorice, 4-8 parts of nandina chinensis, 6-8 parts of lily, 1-2 parts of fritillaria cirrhosa, 2-5 parts of loquat leaves, 1-3 parts of snakegourd seeds, 1-2 parts of snakegourd leaves, 6-8 parts of perilla, 4-6 parts of almond, 3-6 parts of wild chrysanthemum, 2-4 parts of honeysuckle, 5-8 parts of seaweed, 5-10 parts of schisandra chinensis, 4-6 parts of rhizoma cynanchi, 3-7 parts of Chinese cabbage roots, 3-5 parts of sea clam shell powder, 3-6 parts of radix isatidis and 2-6 parts of ephedra. The invention is prepared from natural medicinal materials, and the medicines are combined, warm but not dry and pungent but not scattered, so that the invention is safe and effective, has the effects of clearing heat and detoxicating, ventilating lung and relieving cough, reducing phlegm and relieving asthma, has better treatment effect on external cough, upper respiratory tract infection and bronchitis, and has no side effect. However, the traditional Chinese medicine composition has the advantages of numerous raw materials, undefined action mechanism and unstable effect, and the diarrhea prevention and treatment effect of the composition is not verified in the text.

The Chinese patent application CN201810787483.2 discloses a traditional Chinese medicine compound for preventing and treating diarrhea of livestock and poultry and a preparation process thereof, wherein the traditional Chinese medicine compound is prepared from the following components in parts by weight: 25-30 parts of dandelion, 20-25 parts of glabrous greenbrier rhizome, 25-30 parts of herba violae, 20-25 parts of wild chrysanthemum flower and 25-30 parts of herba patriniae. The preparation method comprises the following steps: weighing the raw materials according to the parts by weight, screening, and crushing the raw materials into superfine powder of 800-1000 meshes; adding 1% sodium hydroxide and water, soaking at 80deg.C for 60 min, separating solid and liquid with horizontal decanter centrifuge and butterfly centrifuge, and adjusting pH of the extractive solution to 3.5-4.0 with diluted hydrochloric acid. Concentrating the above extractive solution with three-effect concentrator to density of 1.05-1.10, centrifuging, filtering, spray drying the concentrated solution to obtain water-soluble product or adsorbing with granular silicon dioxide, and drying with blade screw drying to obtain granular powder. The invention has the functions of clearing away heat and toxic material and resisting inflammation, can obviously inhibit colibacillus which is common pathogenic bacteria of pigs and chickens, and can replace antibiotics to prevent and treat diarrhea of livestock and poultry. However, the traditional Chinese medicine composition has slow onset of action, complex preparation process and further improved curative effect.

Therefore, it is necessary to develop a fermented Chinese herbal medicine preparation for preventing and treating diarrhea of livestock and poultry and a preparation method thereof, which can solve the above technical problems.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provide a fermented Chinese herbal medicine preparation for preventing and treating mixed infection of livestock and poultry, which has the advantages of good curative effect, quick response, convenient use, simple production process and no toxic or side effect, and a preparation method thereof.

The invention is realized by the following technical scheme:

a fermented Chinese herbal medicine composition comprises the following components in percentage by weight: 55-65% of Chinese herbal medicine mixture and 35-45% of yeast culture, wherein the Chinese herbal medicine mixture comprises white paeony root, beautyberry, dried orange peel, largehead atractylodes rhizome, climbing groundsel herb and divaricate saposhnikovia root.

White peony root: bitter acid cold enters the liver, spleen and lung channels, clears and nourishes liver blood, astringes liver and relieves pain;

callicarpa nudiflora: bitter and cold enters the lung and stomach channels, and is dispersed to disperse blood stasis, detumescence, astringe and stop bleeding;

all-grass of groundsel: bitter slight cold enters the large intestine channel of liver and lung, clears away heat and toxic materials, clears liver and improves vision, clears damp and heat;

dried orange peel: pungent and bitter warm entering the lung and spleen and stomach meridians, conditioning spleen qi, drying dampness and resolving phlegm;

white atractylodes rhizome: sweet and bitter, warms the spleen and stomach meridians, and invigorates the spleen and eliminates dampness;

wind prevention: pungent, sweet and slightly warm in nature enter the liver, spleen and bladder meridians, dispelling wind and removing dampness.

Liver wood can control spleen soil, spleen deficiency and excessive dampness, so that the stool is thin, sour and smelly and sticky; liver depression is due to qi-blood disharmony, and dysfunction of water and blood circulation; spleen failing to transport due to excessive liver and spleen deficiency, and damp turbidity stopping internally; therefore, the spleen should be strengthened, the spleen should be enliven, the spleen qi should be dredged, the liver and spleen function should be restored to normal state, and the gastrointestinal function should be restored to normal state; more effectively clearing the enteropathogenic toxins, in particular the spleen and stomach endotoxins, killing harmful microorganisms in the intestinal tract and promoting the mass propagation of beneficial microorganisms; stimulating mesenteric lymph node and lymph follicular, establishing immune barrier, promoting proliferation of mucosal antibody IgA, recovering normal flora, strengthening gastrointestinal tract of livestock and fowl, and promoting healthy growth of livestock and fowl.

Preferably, the Chinese herbal medicine mixture comprises the following components in parts by weight: 9-16 parts of white peony root, 9-16 parts of beautyberry, 8-16 parts of dried orange peel, 9-16 parts of bighead atractylodes rhizome, 9-16 parts of senecio and 9-12 parts of divaricate saposhnikovia root.

Preferably, the yeast culture comprises a yeast bacillus and a basic nutrient.

More preferably, the yeast culture further comprises at least one of lactobacillus, bacillus subtilis and bacillus butyricum.

More preferably, the basic nutrients include biological glycolytic enzymes, vitamins, amino acids and peptones.

More preferably, the biological glycolytic enzyme includes at least one of a cellulase, a protease, a lipase, and a phytase.

More preferably, the yeast culture is a double peptide yeast culture, available from the company Paglia Biotechnology (Gobi) Inc.

The invention also relates to a fermented Chinese herbal medicine preparation, which comprises the fermented Chinese herbal medicine composition.

The invention also relates to a preparation process of the fermented Chinese herbal medicine preparation, which comprises the following steps:

(1) Pulverizing radix Paeoniae alba, folium Callicarpae Formosanae, pericarpium Citri Tangerinae, atractylodis rhizoma, herba Senecionis Scandentis and radix Saposhnikoviae respectively into 100-200 mesh coarse powders, and mixing to obtain Chinese herbal medicine mixture;

(2) Mixing the Chinese herbal medicine mixture with yeast culture for 15-20min, and fermenting for 10-15 days to obtain fermented Chinese herbal medicine preparation.

Preferably, the preparation process of the fermented Chinese herbal medicine preparation comprises the following steps:

The invention also relates to the application of the fermented Chinese herbal medicine composition or the fermented Chinese herbal medicine preparation prepared by the preparation process in preparing medicines for preventing and treating diarrhea of livestock and poultry.

The main cause of diarrhea of livestock and poultry is as follows: viral diarrhea; bacterial diarrhea; thirdly, parasitic diarrhea; fourthly, nutritional and metabolic diarrhea; fifth, environmental stress diarrhea; and sixth, compensatory diarrhea, etc. The main symptoms are as follows: the feces are watery or pasty, grey, yellow to white, and occasionally brown, yellow brown or white in shape due to occult blood, with blood streaks or purulent blood, fishy smell, emaciation, poor hair color, rough and messy hair, poor growth, mental wilt, abdominal pain, urgent back and heavy, and inappetence.

The beneficial effects of the invention are as follows:

the fermented Chinese herbal medicine composition has a reasonable formula. The fermented Chinese herbal medicine composition is prepared by taking one or more probiotics in Chinese herbal medicine and intestinal probiotics as strains, simulating the intestinal environment of an animal body and the digestion and decomposition process of Chinese herbal medicine components in the animal body in vitro by using a microecology and bionics method, performing biological conversion on the effective components of the Chinese herbal medicine, and converting macromolecular substances of the Chinese herbal medicine into small molecular components which can be directly absorbed by the intestinal tract of the animal body through microorganisms, so that the Chinese herbal medicine becomes a novel medicine capable of being rapidly absorbed and quantitatively treating.

The formula compatibility principle of the invention is 'damp-clearing antidiarrheal, spleen-tonifying and liver-softening', and the principal drug of the formula is bighead atractylodes rhizome, which is sweet and bitter in taste and warm in nature, can tonify spleen and remove dampness to treat soil deficiency; the ministerial drug is beautyberry, bitter in taste and cold in nature, and can astringe to stop bleeding, dissipate blood stasis and reduce swelling; qianli Cao, bitter in taste and cold in nature, can clear away heat and toxic materials, clear away dampness and heat; white peony root, bitter in taste and sour in nature, can soften liver, relieve urgency and stop pain to suppress liver hyperactivity; dried orange peel, with the effect of regulating qi, eliminating dampness, activating spleen and stomach; the medicine has the effects of preventing wind, having pungent and bitter taste and warm nature, and being capable of dispersing liver depression, regulating spleen qi, inhibiting liver exuberance, tonifying spleen and eliminating dampness, relieving spasm and pain, eliminating dampness and stopping diarrhea. The aims of eliminating dampness, relieving diarrhea, tonifying spleen and softening liver are achieved together.

The medicines are picked up and matched, and the medicine has the effects of eliminating dampness, relieving diarrhea, tonifying spleen and softening liver; the traditional Chinese medicine has the advantages of wide sources, environmental protection, low cost, quick curative effect, high cure rate, no residue and no toxic or side effect.

The fermented Chinese herbal medicine preparation provided by the invention is convenient to use, simple in preparation process and beneficial to industrial production.

Detailed Description

The invention will be further described with reference to specific embodiments, and advantages and features of the invention will become apparent from the description. These examples are merely exemplary and do not limit the scope of the invention in any way. It will be understood by those skilled in the art that various changes and substitutions of details and forms of the technical solution of the present invention may be made without departing from the spirit and scope of the present invention, but these changes and substitutions fall within the scope of the present invention.

The yeast cultures in the examples below are double peptide yeast cultures, available from the company Papaver, inc. of the environmental protection technology (Gobi).

Example 1

The formula comprises the following components: 20g of white peony root, 15g of beautyberry, 10g of dried orange peel, 30g of bighead atractylodes rhizome, 15g of senecio and 10g of divaricate saposhnikovia root.

The components with sufficient amounts are checked conventionally, crushed into 100 meshes and mixed uniformly for 15 minutes to obtain the Chinese herbal medicine mixture. Adding 35g of yeast culture into 65g of Chinese herbal medicine mixture, uniformly mixing for 15 minutes, fermenting for 10 days, finally preparing a fermented Chinese herbal medicine preparation, checking to be qualified, and sub-packaging for later use.

Example 2

The formula comprises the following components: 25g of white peony root, 20g of beautyberry, 15g of dried orange peel, 35g of bighead atractylodes rhizome, 20g of senecio and 15g of divaricate saposhnikovia root.

The components with sufficient amounts are checked conventionally, crushed into 200 meshes and mixed uniformly for 20 minutes to obtain the Chinese herbal medicine mixture. Adding 38g of yeast culture into 62g of Chinese herbal medicine mixture, uniformly mixing for 15 minutes, fermenting for 15 days, finally preparing a fermented Chinese herbal medicine preparation, checking to be qualified, and sub-packaging for later use.

Example 3

The formula comprises the following components: 30g of white peony root, 25g of beautyberry, 20g of dried orange peel, 40g of bighead atractylodes rhizome, 25g of senecio and 20g of divaricate saposhnikovia root.

The components with sufficient amounts are checked conventionally, crushed into 150 meshes and mixed evenly for 15 minutes to obtain the Chinese herbal medicine mixture. Adding 38g of yeast culture into 62g of Chinese herbal medicine mixture, uniformly mixing for 15 minutes, fermenting for 12 days, finally preparing a fermented Chinese herbal medicine preparation, checking to be qualified, and sub-packaging for later use.

Example 4

The formula comprises the following components: 35g of white peony root, 30g of beautyberry, 25g of dried orange peel, 45g of bighead atractylodes rhizome, 30g of senecio and 25g of divaricate saposhnikovia root.

The components with sufficient amounts are checked conventionally, crushed into 100 meshes and mixed uniformly for 15 minutes to obtain the Chinese herbal medicine mixture. Adding 38g of yeast culture into 62g of Chinese herbal medicine mixture, uniformly mixing for 15 minutes, fermenting for 10 days, finally preparing a fermented Chinese herbal medicine preparation, checking to be qualified, and sub-packaging for later use.

Example 5

The formula comprises the following components: 40g of white peony root, 35g of beautyberry, 30g of dried orange peel, 50g of bighead atractylodes rhizome, 35g of senecio, and 30g of divaricate saposhnikovia root.

The components with sufficient amounts are checked conventionally, crushed into 100 meshes and mixed uniformly for 20 minutes to obtain the Chinese herbal medicine mixture. Adding 40g of yeast culture into 60g of Chinese herbal medicine mixture, uniformly mixing for 15 minutes, fermenting for 15 days, finally preparing a fermented Chinese herbal medicine preparation, checking to be qualified, and sub-packaging for later use.

Example 6

The formula comprises the following components: 45g of white peony root, 40g of beautyberry, 35g of dried orange peel, 55g of bighead atractylodes rhizome, 40g of senecio and 35g of divaricate saposhnikovia root.

The components with sufficient amounts are checked conventionally, crushed into 100 meshes and mixed uniformly for 15 minutes to obtain the Chinese herbal medicine mixture. Adding 40g of yeast culture into 60g of Chinese herbal medicine mixture, uniformly mixing for 20 minutes, fermenting for 13 days, finally preparing a fermented Chinese herbal medicine preparation, checking to be qualified, and sub-packaging for later use.

Example 7

The formula comprises the following components: 50g of white peony root, 45g of beautyberry, 40g of dried orange peel, 60g of bighead atractylodes rhizome, 45g of senecio, and 40g of divaricate saposhnikovia root.

The components with sufficient amounts are checked conventionally, crushed into 100 meshes and mixed uniformly for 20 minutes to obtain the Chinese herbal medicine mixture. Adding 40g of yeast culture into 60g of Chinese herbal medicine mixture, uniformly mixing for 15 minutes, fermenting for 14 days, finally preparing a fermented Chinese herbal medicine preparation, checking to be qualified, and sub-packaging for later use.

Example 8

The formula comprises the following components: 55g of white peony root, 50g of beautyberry, 45g of dried orange peel, 65g of bighead atractylodes rhizome, 50g of senecio and 45g of divaricate saposhnikovia root.

The components with sufficient amounts are checked conventionally, crushed into 100 meshes and mixed uniformly for 15 minutes to obtain the Chinese herbal medicine mixture. Adding 40g of yeast culture into 60g of Chinese herbal medicine mixture, uniformly mixing for 15 minutes, fermenting for 10 days, finally preparing a fermented Chinese herbal medicine preparation, checking to be qualified, and sub-packaging for later use.

Example 9

The formula comprises the following components: 60g of white peony root, 55g of beautyberry, 50g of dried orange peel, 70g of bighead atractylodes rhizome, 55g of senecio and 50g of divaricate saposhnikovia root.

The components with sufficient amounts are checked conventionally, crushed into 100 meshes and mixed uniformly for 15 minutes to obtain the Chinese herbal medicine mixture. Adding 45g of yeast culture into 55g of Chinese herbal medicine mixture, uniformly mixing for 15 minutes, fermenting for 10 days, finally preparing a fermented Chinese herbal medicine preparation, checking to be qualified, and sub-packaging for later use.

Example 10

The formula comprises the following components: 60g of white peony root, 60g of beautyberry, 55g of dried orange peel, 75g of bighead atractylodes rhizome, 60g of climbing groundsel herb and 55g of divaricate saposhnikovia root.

Comparative example 1

The difference from example 1 is only that the dosage proportions of the components are different, and the other conditions are the same, and the specific conditions are as follows:

the formula comprises the following components: 14g of white peony root, 28g of beautyberry, 5g of dried orange peel, 28g of bighead atractylodes rhizome, 5g of senecio and 20g of divaricate saposhnikovia root.

Comparative example 2

The difference from example 1 is that the total mass of beautyberry, bighead atractylodes rhizome and senecio is unchanged, the beautyberry is not contained, and the mass ratio of bighead atractylodes rhizome to senecio is unchanged, specifically as follows:

the formula comprises the following components: 20g of white peony root, 10g of dried orange peel, 40g of bighead atractylodes rhizome, 20g of groundsel and 10g of divaricate saposhnikovia root.

Comparative example 3

The difference from example 1 is that the total mass of beautyberry, white atractylodes rhizome and senecio is unchanged, no white atractylodes rhizome and senecio are contained, and beautyberry is contained only, specifically as follows:

the formula comprises the following components: 20g of white peony root, 60g of beautyberry, 10g of dried orange peel and 10g of divaricate saposhnikovia root.

Effect of the invention

The dosage of the fermented Chinese herbal medicine preparation is as follows: the fermented Chinese herbal medicine preparation is added according to the total price of 0.5-1 percent and is used for 5-10 days.

The amounts of each drug in the same application case are the same.

Application example 1

Address: pig farm Wang Mou in Jiangxi Jiangzhou Nankang region

In the period of 20 days of 4.2018, wang Mou, 600 sows are raised, 869 sows are raised, the whole fattening pigs have poor feed intake, a small part of sows also have mastitis, the whole herd of pigs has diarrhea manure, and most of water-like manure is also yellow-white, yellow-green and undigested feed in the thin manure. Pig herds show coarse fur, squinting eyes and flushing conjunctiva. The definite diagnosis of swine transmissible gastroenteritis, rotavirus infection, ileitis and other infections is carried out after 5 months 12, and the effects of the Chinese herbal medicine powder (such as plague clearing and toxin relieving powder, yinfang powder and the like) and the sulfanilamide-2-methoxypyrimidine, doxycycline, florfenicol and the like are not obvious. Every 5 months and 28 days, 600 diarrhea sows and 800 diarrhea fat pigs are randomly divided into 4 groups of 150 sows and 200 fat pigs. The products of the invention of example 1 and comparative examples 1-3 were added at 1% of full price for 10 days. Observing on the 7 th day, the sow group and the fat pig group in the example 1 have good spirit, improved excrement, increased feed intake, and also slowly improved mastitis, and the milk production is vigorous, the eyes are red and bright, the fur is red and moist, and the diarrhea cure rate is 100%; the diarrhea of 20 sows and 32 fat pigs in the group 1 is not improved, and the diarrhea cure rate is 85.14%; the diarrhea of 45 sows and 53 fattening pigs in the group of comparative example 2 is not improved, and the diarrhea cure rate is 72%; the diarrhea of 56 sows and 71 fat pigs in the group 3 of comparative example is not improved, and the diarrhea cure rate is 63.71%. The product has the effects of preventing and treating the infection of transmissible gastroenteritis, rotavirus, ileitis and the like of swine herd, has no toxic and side effect after use, has no drug residue, has low cost, and is a safe, green and environment-friendly fermented Chinese herbal medicine preparation.

Application example 2

Address: special households for beef cattle in Jiangxi province Hui Chang county raise a certain position

In the year 6 and 23 of 2017, 546 heads of a certain raised beef cattle are raised, and since the year 2017, beef cattle in the beef cattle group are uneven in feeding, the time is high, the time is low, and the feeding amount is reduced; diluting and softening the manure; mental depression; ruminal ruminant diminution; drying oral mucosa, and depressing eye socket; easily causes laminitis and the like; the mixed infection of infectious gastroenteritis, salmonella and parasites and chronic acidosis of beef cattle is diagnosed by animal quarantine analysis laboratory of animal medical system of Jiangxi agricultural university. The product of the invention of the example 3 is added according to 1% of the total price for 10 days. Then observing that the feeding and the feces of the whole cattle are recovered to be normal, the feeding amount is gradually increased, the feces are formed, the eyes are clear and bright, the oral mucosa is pink and moist, the mental condition is improved, the ruminant is recovered to be normal, and the ruminant is ruminant for 12-14 times a day, 40-50 minutes each time, which shows that the product of the invention has good effect on mixed infection of transmissible gastroenteritis, salmonella, parasites and chronic acidosis of beef cattle, and healthy fattening of the beef cattle is ensured, so the product of the invention is a safe, green and environment-friendly fermented Chinese herbal medicine preparation.

Application example 3

Address: liu Mou for certain milk goat farm in Wenchang City of Hainan province

8 days of 10 months of 2015, liu Mou, 3214 milk goats are bred, the whole milk goats have poor feed intake, yellowish white or gray green thin manure and unsatisfactory milk yield after the last half of 2015, and the goats are produced to be emaciated, coarse fur, squinting eyes, conjunctival flushing and diagnosed as rotavirus infection, salmonella disease and parasitic infection by animal medicine laboratories of agricultural university of south China. The product of the invention example 4 is added according to 1% of the total price for 10 days. After administration, the milk goats are observed to have good spirit, improved excrement, obviously increased milk yield, increased feed intake, vigorous milk production, snow eyes and red fur. The product of the invention has definite effect on preventing and treating rotavirus, salmonella and parasite mixed infection of milk goats, has no toxic and side effect after use, has no drug residue, low cost and high effective protection rate, and is a safe, green and environment-friendly fermented Chinese herbal medicine preparation.

Application example 4

Address: tri-yellow chicken farm Lv Mou in Ningdu county in Jiangxi province

After the three yellow chickens 12698 feather of 78 days are bred in 5 months and 12 days of 2018 and Lv Mou and the three yellow chickens of 78 days are bred in 2 months and 10 days of 2018, the chicken newcastle disease and the coccidiosis complicated by colibacillosis are basically cured, but some chicken groups with about 1/3 of the spirit difference have sub-health symptoms such as softer feces, fluffy feather, no blood color, uneven growth and the like; it is also seen that a small portion of chickens have watery feces, 15 days 5.2018, and begin to add 1% of the daily ration using the product of example 5 of the invention for 10 days. The chickens were observed for 20 days, and the chickens were mental, fecal was improved, feathers were moist, responsive, active and even in growth until the chickens were out of the pen. The product of the invention has the advantages of improving the sub-health of chickens, preventing and curing diarrhea of chickens, no toxic or side effect, no drug residue after use, low cost and high effective protection rate, and is a safe, green and environment-friendly fermented Chinese herbal medicine preparation.

Application example 5

Address: guo Mou base for breeding ducks in four meeting provinces in Guangdong

The 20 th 3 rd 2017, guo Mou feeding the 74874 th feather of 248 th year, the laying rate is 65%, the laying individuals are small, the laying ducks are thin all the time from the beginning of laying, the feed intake is low, the average feed per feather duck is 0.3 jin, the ducks are thin, the feathers are rough, the wasting is realized, the whole ducks are in a sub-health state, the obvious resistance is low, and in order to improve the sub-health state of the ducks, the product of the embodiment 2 of the invention is added according to 1% of the whole ducks, and the whole ducks are continuously used for 10 days. The ducks are observed for 25 days, the spirit is improved, the feces is improved, the laying rate is obviously increased to more than 85%, the feed intake is increased, the average feed intake of each feather duck is more than 0.33 jin, and the feathers are moist, sensitive in response and active in growth. The product of the invention has the advantages of improving the sub-health of ducks, resisting diarrhea of ducks, no toxic or side effect after use, no drug residue, low cost and high effective protection rate, and is a safe, green and environment-friendly fermented Chinese herbal medicine preparation.

Application example 6

Address: base Wang Mou for laying hen in Qing mountain of Nanchang county in Nanchang city of Jiangxi province

In 2019, wang Mou feeds 10000 feathers of 41-day-old laying hens, the feed intake of the chickens is reduced from 3 months and 3 days, the chickens are in mental wilt and gradually lean, green manure is pulled, blood and silk are carried in the manure, a fishy smell is taken in the chicken house, wang Mou considers that the chickens suffer from bacterial diseases such as colibacillosis, salmonella and clostridium welfare, and then the chickens are mixed with the carbendazim, enrofloxacin and furin for 5-7 days, but the effect is not obvious, 568 feathers die, and then the manure is adopted to laboratory tests of animal medicine laboratory veterinary analysis of the agricultural university of Jiangxi, and the result is epidemic diarrhea of birds, colibacillosis, salmonella and coccidiosis of chickens. Immediately after that, the product of the invention of the example 9 is added according to 1% of daily ration, and the use is continued for 10 days, the blood and the feces are less in the third day of the use, the feces are softened from thin, and the feces are improved after the seventh day, so that death is stopped. The product has the advantages of no toxic or side effect after use, no drug residue, low cost and high effective protection rate, and is a safe, efficient, green, environment-friendly and anti-diarrhea fermented Chinese herbal medicine preparation.

Practical example 7

Address: special households Chen Mou for raising geese in Yongfeng county in Jiangxi province

Purchasing 6000 feathers of geese in 2019, 4 months and 2 months, and generating serous secretion from mental depression, sleepiness, necking, weakness of two feet, slow action, anorexia, eyes and nose in 4 months and 14 days; pulling yellow green thin manure; the anus pollutes the feces. The fibropericarditis, perihepatitis and air sac inflammation are detected by dissection; arthritis, arthrocele, yellow liver, bleeding points with different sizes on the surface, and pulmonary, splenic and renal swelling bleeding, etc., and finally, mixed infection of infectious serositis of geese, gosling viral hepatitis and goose salmonella is confirmed. The gosling viral hepatitis refined serum is injected immediately, and the product of the embodiment 10 of the invention is added according to 1% of the total price for 10 days. The next day of administration, the death is greatly reduced except for the death of the stark, the askew head and the torticollis and the general spastic tic convulsion, and the death is stopped in the fifth day, so that the recovery is basically realized. The product of the invention has the advantages of definite effect in treating the disease, no toxic or side effect after use, no drug residue, low cost and high effective protection rate, and is a safe, efficient, green and environment-friendly fermented Chinese herbal medicine preparation.

The foregoing detailed description is directed to one of the possible embodiments of the present invention, which is not intended to limit the scope of the invention, but is to be accorded the full scope of all such equivalents and modifications so as not to depart from the scope of the invention.

Claims

1. The fermented Chinese herbal medicine composition for preventing and treating diarrhea of livestock and poultry is characterized by comprising the following components in parts by weight: 20g of white peony root, 15g of beautyberry, 10g of dried orange peel, 30g of bighead atractylodes rhizome, 15g of senecio, and 10g of divaricate saposhnikovia root;

the preparation process of the fermented Chinese herbal medicine composition comprises the following steps:

the components with sufficient amounts are checked conventionally and crushed into 100 meshes, and the mixture is evenly mixed for 15 minutes to obtain a Chinese herbal medicine mixture; and adding 35g of yeast culture into 65g of the Chinese herbal medicine mixture, uniformly mixing for 15 minutes, fermenting for 10 days together, and finally preparing the fermented Chinese herbal medicine preparation, wherein the yeast culture is a double peptide yeast culture.

2. A fermented Chinese herbal medicine preparation for preventing and treating diarrhea of livestock and poultry, which is characterized by comprising the fermented Chinese herbal medicine composition according to claim 1.

3. A process for preparing a fermented chinese herbal formulation as claimed in claim 2, comprising the steps of:

(1) Pulverizing radix Paeoniae alba, folium Callicarpae Formosanae, pericarpium Citri Tangerinae, atractylodis rhizoma, herba Senecionis Scandentis and radix Saposhnikoviae into 100 mesh, and mixing for 15 min to obtain Chinese herbal medicine mixture;

(2) Adding 35g of yeast culture into 65g of Chinese herbal medicine mixture, uniformly mixing for 15 minutes, fermenting for 10 days, and finally preparing the fermented Chinese herbal medicine preparation.

4. The use of the fermented chinese herbal medicine composition of claim 1 or the fermented chinese herbal medicine formulation of claim 2 or the fermented chinese herbal medicine formulation prepared by the preparation process of claim 3 in the preparation of a medicament for preventing and treating diarrhea in livestock and poultry.