CN107007640A - A kind of production method for preventing and treating livestock and birds respiratory disease product - Google Patents

A kind of production method for preventing and treating livestock and birds respiratory disease product Download PDF

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CN107007640A
CN107007640A CN201710427501.1A CN201710427501A CN107007640A CN 107007640 A CN107007640 A CN 107007640A CN 201710427501 A CN201710427501 A CN 201710427501A CN 107007640 A CN107007640 A CN 107007640A
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chinese herbal
production method
herbal medicine
respiratory disease
preventing
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李德彬
陈刚
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TAICANG YOUHUO BIOTECHNOLOGY Co Ltd
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TAICANG YOUHUO BIOTECHNOLOGY Co Ltd
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    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747Lactobacilli, e.g. L. acidophilus or L. brevis
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/062Ascomycota
    • A61K36/064Saccharomycetales, e.g. baker's yeast
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    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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Abstract

The invention discloses a kind of production method for preventing and treating livestock and birds respiratory disease product, the probiotics such as Bifidobacterium Bifidum, lactic acid bacteria, Bacillus, saccharomycete and its metabolite and Chinese herbal medicine tunning, prebiotics, respiratory tract and the one or more of of intestinal mucosa reparative factor are mixed by a certain percentage.Through the above way, what the present invention was provided prevents and treats the production method of livestock and birds respiratory disease product, the product coordinates oral administration effectively to prevent and treat livestock and birds respiratory disease by atomized medicine introducing, reduce or prevent the use of antibiotic in breeding process, suppress the generation of breathing problem by improving the health of respiratory mucosa and intestinal mucosa, improve feed digestibility, reduce aquaculture cost, the residual of antibiotic in animal product is reduced, the animal product for production green, noresidue provides technology and product support.

Description

A kind of production method for preventing and treating livestock and birds respiratory disease product
Technical field
It is specifically a kind of the present invention relates to a kind of product processes for preventing and treating livestock and birds respiratory disease Mixed by a certain percentage by the one or more of probiotics and its metabolite, Chinese herbal medicine, respiratory mucosa reparative factor.
Background technology
The aquaculture of China passes through the development of decades, scale, intensive degree more and more higher, with New Oversea Products kind Introduction, circulation widens, and the increase of stocking density is that the prevalence of breathing problem creates objective condition, respiratory tract Disease also increasingly becomes a big obstacle of aquaculture development.
1 )Feeding management be not good at or stress factor caused by respiratory diseases(Environmental factor)
a:Cold stress, such as weather cool, and thermal source breaks down, and the factor such as excessive of divulging information and interior have harmful wind or draught to cause house Warm fusion, causes the respiratory symptoms such as sneeze, cough;
b:Dust and pernicious gas in improper ventilation, house(Ammonia, hydrogen sulfide, carbon dioxide etc.)Too high levels, if now divulging information Bad, then harmful gas concentration is too high, stimulates respiratory mucosa, causes respiratory symptom;
c:Density is too high in pouity dwelling place
d:In band chicken spraying disinfection, the big disinfectant of excitant is used:Such as chloride class, Lysol, can stimulate respiratory tract to stick Film, causes respiratory symptom;
Above stress factor, can all stimulate respiratory mucosa, not only cause corresponding respiratory symptom, while also making respiratory tract The resistance of mucous membrane is reduced, now some pathogenic microorganisms(Such as bacterium, mycoplasma)It will avail oneself of the opportunity to get in, cause more serious biography Metachromia breathing problem, now, it is invalid to throw the medicines such as antibiotic in the treatment time, it is necessary to which coordinating the improvement of environment could obtain Good effect.
2)Respiratory diseases caused by vaccine improper use
3)Strong poison seedling repeatedly, Use out of range when, internal pathogen may be caused to accumulate, cause vaccine virus to infect
4)By pathogenic microorganism(Virus, bacterium and mycoplasma etc.)Caused respiratory diseases
Ewcastle disease, bird flu, infective bronchitis, infectious laryngotracheitis, chronic respiratory tract disease, infective rhinitis, large intestine Bacillosis etc. has respiratory symptom performance, but their cause of disease is different.And more complicated is two kinds or two kinds Above respiratory pathogen acts on animal respiratory simultaneously or successively, pathogenic synergy can be produced between them, than single Pathogen associated diseases are much serious.Especially some inhibitive ability of immunity diseases, occur the chicken group of breathing problem and exist to exempt from When epidemic disease suppresses pathogen, breathing problem can be very serious and uncontrollable.
The content of the invention
The present invention solves the technical problem of provide a kind of life for preventing and treating livestock and birds respiratory disease product Production method, the product coordinates oral administration effectively to prevent and treat livestock and birds respiratory disease by atomized medicine introducing, reduce or Prevent the use of antibiotic in breeding process, suppress the hair of breathing problem by improving the health of respiratory mucosa and intestinal mucosa Life, improves feed digestibility, reduces aquaculture cost, reduces the residual of antibiotic in animal product, green, noresidue for production Animal product provides technology and product support.
In order to solve the above technical problems, one aspect of the present invention is:It can be prevented and treated there is provided one kind The production method of livestock and birds respiratory disease product, by probiotics and its metabolite and Chinese herbal medicine tunning, prebiotics, breathing Road is mixed by a certain percentage with the one or more of intestinal mucosa reparative factor, and described preparation method comprises the following steps:
1)Prepare seed liquor
By the one or more in Bifidobacterium Bifidum, lactic acid bacteria, Bacillus, saccharomycete, the liquid seeds training after the corresponding sterilizing of access Support in base, cultivating 24-72h in 24-38 DEG C obtains seed liquor;
2)Prepare probiotics fermention liquid
By the one or more in Bifidobacterium Bifidum, lactic acid bacteria, Bacillus, saccharomycete, the liquid fermentation training after the corresponding sterilizing of access Support in base, cultivating 48-96h in 24-38 DEG C obtains zymotic fluid;
3)Prepare probiotics and its metabolite
Corresponding bacterium mud is obtained after probiotics fermention liquid is centrifuged, carrier is then added and is freeze-dried, it is ensured that be living after drying The quantity of bacterium is in certain valid value range, and fermented supernatant fluid after centrifugation carries out being lotion after cryogenic vacuum concentration, by with Upper method respectively obtains probiotics and dries viable bacteria powder and supernatant cream mud;
Or, it is that probiotics fermention liquid is directly carried out to cryogenic vacuum to concentrate to be cream mud;
4)Prepare Chinese herbal medicine tunning
By Chinese herbal medicine after ultramicro grinding is handled, the fermentation rich in Chinese herbal medicine effective ingredientses is obtained after probiotics fermention and is produced Thing, is then prepared into Chinese recipe mud;
5)Preparation can carry out the preparation of atomized medicine introducing
Probiotics and its metabolite are pressed one with the one or more in Chinese herbal medicine tunning, respiratory mucosa reparative factor Certainty ratio, which is mixed with, can carry out the preparation of atomized medicine introducing;
6)Prepare orally available preparation
By probiotics and its metabolite and Chinese herbal medicine tunning, respiratory mucosa reparative factor, intestinal mucosa reparative factor In one or more be mixed with orally available preparation by a certain percentage;
7)Compatibility is combined with quantitative prebiotics.
In a preferred embodiment of the present invention, described probiotics fermention liquid is through 3000-6000r/min × 5-20min Centrifugal treating.
In a preferred embodiment of the present invention, described Chinese herbal medicine uses one effective to treatment breathing problem to hit Herbal medicine, includes but is not limited to:Radix Isatidis, gypsum, the dried rhizome of rehmannia, balloonflower root, the coptis, radix scutellariae, cape jasmine, radix scrophulariae, the capsule of weeping forsythia, two flowers, safflower, Rheum officinale, saltcake, radix glycyrrhizae, conjunction cape jasmine, honeysuckle, myrobalan, caulis bambusae in taenian, golden cypress, the root of herbaceous peony, gypsum, saltcake, folium isatidis, Radix Et Rhizoma Rhei, Soviet Union It is son, gingko, almond, double skins, tussilago, Chinese ephedra, cordate houttuynia, ginseng, ganoderma lucidum, honeysuckle, schizonepeta, windproof, cassia twig, loguat leaf, old Tealeaves, Plant Soot, the wind-weed, fritillaria, balloonflower root, mulberry skin, loguat leaf, lepidium seed, the tuber of dwarf lilyturf, alstonia-leaf, Rajmahal creeper, cacumen biotae, stone green pepper Grass, pappy shell, Verbena officinalis, kuh-seng, the tuber of pinellia, cape jasmine, Radix Angelicae Sinensis, the achene of Siberian cocklebur, the bighead atractylodes rhizome, injustice silk, radix bupleuri, fructus psoaleae, dried orange peel.
In a preferred embodiment of the present invention, fineness after described Chinese herbal medicine ultra-fine powder is broken 100-6000 mesh it Between.
In a preferred embodiment of the present invention, described Chinese herbal medicine probiotics fermention mode is divided into solid fermentation and liquid Fermentation.
In a preferred embodiment of the present invention, the mode of described solid fermentation is divided into aerobic fermentation, anaerobic fermentation, elder generation It is aerobic after aerobic rear anaerobism or first anaerobism.
In a preferred embodiment of the present invention, described liquid fermentation is quantitative bacterium will to be added after Chinese herbal medicine micro mist Culture medium accesses corresponding probiotics strain after high-temperature sterilization and carries out aerobic or anaerobic fermentation.
In a preferred embodiment of the present invention, described respiratory mucosa reparative factor can answer respiratory tract using all Material, including but not limited to EGF.
In a preferred embodiment of the present invention, described intestinal mucosa reparative factor can repair the thing of enteron aisle using all Matter, including but not limited to EGF.
In a preferred embodiment of the present invention, described prebiotics be oligosaccharide, polysaccharide, vegetable Chinese herbal medicine extract, Protein hydrolysate or polyalcohol.
The beneficial effects of the invention are as follows:The production method for preventing and treating livestock and birds respiratory disease product of the present invention, The product coordinates oral administration effectively to prevent and treat livestock and birds respiratory disease by atomized medicine introducing, reduces or prevents cultivation During antibiotic use, suppress the generation of breathing problem by improving the health of respiratory mucosa and intestinal mucosa, improve Feed digestibility, reduces aquaculture cost, reduces the residual of antibiotic in animal product, for production green, the animal system of noresidue Product provide technology and product support.
Brief description of the drawings
Technical scheme in order to illustrate the embodiments of the present invention more clearly, makes required in being described below to embodiment Accompanying drawing is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the present invention, for For those of ordinary skill in the art, on the premise of not paying creative work, it can also obtain other according to these accompanying drawings Accompanying drawing, wherein:
Fig. 1 is the structure stream of a preferred embodiment of the production method that the present invention can prevent and treat livestock and birds respiratory disease product Cheng Tu.
Embodiment
The technical scheme in the embodiment of the present invention will be clearly and completely described below, it is clear that described implementation Example is only a part of embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, this area is common All other embodiment that technical staff is obtained under the premise of creative work is not made, belongs to the model that the present invention is protected Enclose.
As shown in figure 1, the embodiment of the present invention includes:
A kind of production method for preventing and treating livestock and birds respiratory disease product, by Bifidobacterium Bifidum, lactic acid bacteria, Bacillus, ferment The probiotics such as female bacterium and its metabolite and the one of Chinese herbal medicine tunning, prebiotics, respiratory tract and intestinal mucosa reparative factor Kind or it is several mix by a certain percentage, described preparation method comprises the following steps:
1)Prepare seed liquor
By the one or more in Bifidobacterium Bifidum, lactic acid bacteria, Bacillus, saccharomycete, the liquid seeds training after the corresponding sterilizing of access Support in base, cultivating 24-72h in 24-38 DEG C obtains seed liquor;
2)Prepare probiotics fermention liquid
By the one or more in Bifidobacterium Bifidum, lactic acid bacteria, Bacillus, saccharomycete, the liquid fermentation training after the corresponding sterilizing of access Support in base, cultivating 48-96h in 24-38 DEG C obtains zymotic fluid;
3)Prepare probiotics and its metabolite
Corresponding bacterium mud is obtained after probiotics fermention liquid is centrifuged, carrier is then added and is freeze-dried, it is ensured that be living after drying The quantity of bacterium is in certain valid value range, and fermented supernatant fluid after centrifugation carries out being lotion after cryogenic vacuum concentration, by with Upper method respectively obtains probiotics and dries viable bacteria powder and supernatant cream mud, wherein, described probiotics fermention liquid is through 3000- 6000r/min × 5-20min centrifugal treatings;
Or, it is that probiotics fermention liquid is directly carried out to cryogenic vacuum to concentrate to be cream mud;
4)Prepare Chinese herbal medicine tunning
By Chinese herbal medicine after ultramicro grinding is handled, the fermentation rich in Chinese herbal medicine effective ingredientses is obtained after probiotics fermention and is produced Thing, is then prepared into Chinese recipe mud, wherein, fineness after described Chinese herbal medicine ultra-fine powder is broken 100-6000 mesh it Between;
5)Preparation can carry out the preparation of atomized medicine introducing
Probiotics and its metabolite are pressed one with the one or more in Chinese herbal medicine tunning, respiratory mucosa reparative factor Certainty ratio, which is mixed with, can carry out the preparation of atomized medicine introducing;
6)Prepare orally available preparation
By probiotics and its metabolite and Chinese herbal medicine tunning, respiratory mucosa reparative factor, intestinal mucosa reparative factor In one or more be mixed with orally available preparation by a certain percentage;
7)Compatibility is combined with quantitative prebiotics.
In above-mentioned, described probiotics strain is as defined in Minister Agriculture of China in microorganism fodder strain Directory Scope.
Described Chinese herbal medicine be Radix Isatidis, gypsum, the dried rhizome of rehmannia, balloonflower root, the coptis, radix scutellariae, cape jasmine, radix scrophulariae, the capsule of weeping forsythia, two flower, Safflower, rheum officinale, saltcake, radix glycyrrhizae, conjunction cape jasmine, honeysuckle, myrobalan, caulis bambusae in taenian, golden cypress, the root of herbaceous peony, gypsum, saltcake, folium isatidis, river are big Huang, perillaseed, gingko, almond, double skins, tussilago, Chinese ephedra, cordate houttuynia, ginseng, ganoderma lucidum, honeysuckle, schizonepeta, windproof, cassia twig, loquat Leaf, old tea, Plant Soot, the wind-weed, fritillaria, balloonflower root, mulberry skin, loguat leaf, lepidium seed, the tuber of dwarf lilyturf, alstonia-leaf, Rajmahal creeper, cacumen biotae, Boenninghausenia sessilicarpa, pappy shell, Verbena officinalis, kuh-seng, the tuber of pinellia, cape jasmine, Radix Angelicae Sinensis, the achene of Siberian cocklebur, the bighead atractylodes rhizome, injustice silk, radix bupleuri, fructus psoaleae, dried orange peel Deng to treatment breathing problem effectively all Chinese herbal medicines.
Further, described Chinese herbal medicine probiotics fermention mode is divided into solid fermentation and liquid fermentation, and wherein solid is sent out Ferment can be divided into the several ways such as aerobic after aerobic fermentation, anaerobic fermentation, first aerobic rear anaerobism, first anaerobism.Liquid fermentation is by Quantitative bacteria culture media is added after herbal medicine micro mist corresponding probiotics strain is accessed after high-temperature sterilization and carried out aerobic or detest Aerobe fermentation.
Wherein, described respiratory mucosa reparative factor is EGF(People's oligopeptides -1)The thing of respiratory tract can be repaired Deng all Matter;Described intestinal mucosa reparative factor is EGF(People's oligopeptides -1)The material of enteron aisle can be repaired Deng all.
Further, described prebiotics be oligosaccharide, it is polysaccharide, vegetable Chinese herbal medicine extract, protein hydrolysate, many First alcohol etc..
Embodiment:
Probiotics by taking lactobacillus acidophilus, bacillus subtilis, saccharomyces cerevisiae as an example, Chinese herbal medicine by taking Radix Isatidis as an example, prebiotics with Exemplified by oligoisomaltose.
1)Prepare probiotics seed liquor
By lactobacillus acidophilus, bacillus subtilis test tube strains, in the liquid seed culture medium after the corresponding sterilizing of access, in 37 DEG C Culture 36h obtains seed liquor;
By saccharomyces cerevisiae test tube strains, in the liquid seed culture medium after the corresponding sterilizing of access, cultivate 48h in 28 DEG C and obtain seed Liquid.
2)Prepare zymotic fluid
By lactobacillus acidophilus seed liquor, in the liquid fermentation medium after the corresponding sterilizing of access, cultivate 72h in 37 DEG C and fermented Liquid;
By bacillus subtilis seed liquor, in the liquid fermentation medium after the corresponding sterilizing of access, cultivate 48h in 37 DEG C and sent out Zymotic fluid;
By saccharomyces cerevisiae seed liquor, in the liquid fermentation medium after the corresponding sterilizing of access, cultivate 48h in 28 DEG C and fermented Liquid.
3)Prepare probiotics and its metabolite
By lactobacillus acidophilus, bacillus subtilis fermentation liquor 6000r/min × 10min centrifugal treatings, collect and add respectively after bacterium mud Enter and be freeze-dried in the skimmed milk solution that concentration is 20%;
By fermentation by saccharomyces cerevisiae liquid 3000r/min × 5min centrifugal treatings, collect after bacterium mud added by 20% addition it is dry In soluble starch, 37 DEG C of vacuum and low temperature drying;
Lactobacillus acidophilus, bacillus subtilis, saccharomyces cerevisiae centrifugation after fermentation supernatant are added into drying by 80% addition In soluble starch, 37 DEG C of vacuum and low temperature drying.
4)Prepare Chinese herbal medicine tunning
By Radix Isatidis after ultramicro grinding to 380 mesh, by 1:0.5 amount adds the bacterium solution containing profitable probliotics, after stirring 37 DEG C fermentation 10 days after take out 80 DEG C dry to obtain Radix Isatidis solid fermentation thing powder;
By Radix Isatidis after ultramicro grinding to 380 mesh, added by 10% amount and contain probiotics fermention culture medium bacterium solution, through 121 DEG C × 30min sterilization treatments after, after zymotic fluid 6000r/min × 10min centrifugal treatings supernatant will be taken to be concentrated through cryogenic vacuum To the weak solution that dry matter content is 5.0%;
By Radix Isatidis after ultramicro grinding to 380 mesh, added by 10% amount and contain probiotics fermention culture medium bacterium solution, through 121 DEG C × 30min sterilization treatments after, by the drying of 80 DEG C of zymotic fluid solid residue to moisture below 14%.
5)Prebiotics uses food-grade oligoisomaltose.
Product formula is constituted
Spray delivery is formulated:100 grams of the powder of fermented liquid supernatant containing lactobacillus acidophilus, fermentation of bacillus subtilis in per 1000ml products 100 grams of liquid supernatant powder, 200 grams of fermentation by saccharomyces cerevisiae liquid supernatant powder, Radix Isatidis tunning content are 5% weak solution 500ml, low 150 grams of IMO, adds distilled water and is settled to 1000ml.
Formulation for oral delivery:50 grams of powder containing lactobacillus acidophilus, 80 grams of bacillus subtilis powder, wine brewing in every 1000 grams of products 20 grams of yeast bacterium powder, 300 grams of oligoisomaltose.On 200 grams of bacillus subtilis fermentation liquor supernatant powder, fermentation by saccharomyces cerevisiae liquid Clear 100 grams of powder, 50 grams of Radix Isatidis zymotic fluid solid residue, 200 grams of Radix Isatidis solid fermentation thing powder.
In summary, the production method for preventing and treating livestock and birds respiratory disease product of the invention, the product passes through Atomized medicine introducing coordinates oral administration effectively to prevent and treat livestock and birds respiratory disease, reduces or prevents antibiosis in breeding process The use of element, suppresses the generation of breathing problem by improving the health of respiratory mucosa and intestinal mucosa, improves feed digestibility, Reduce aquaculture cost, reduce animal product in antibiotic residual, for production green, noresidue animal product provide technology and Product support.
Embodiments of the invention are the foregoing is only, are not intended to limit the scope of the invention, it is every to utilize this hair Equivalent structure or equivalent flow conversion that bright description is made, or directly or indirectly it is used in other related technology necks Domain, is included within the scope of the present invention.

Claims (10)

1. a kind of production method for preventing and treating livestock and birds respiratory disease product, it is characterised in that by probiotics and its generation Thank product and Chinese herbal medicine tunning, prebiotics, respiratory tract and intestinal mucosa reparative factor it is one or more of by a certain percentage Mixing, described preparation method comprises the following steps:
1)Prepare seed liquor
By the one or more in Bifidobacterium Bifidum, lactic acid bacteria, Bacillus, saccharomycete, the liquid seeds training after the corresponding sterilizing of access Support in base, cultivating 24-72h in 24-38 DEG C obtains seed liquor;
2)Prepare probiotics fermention liquid
By the one or more in Bifidobacterium Bifidum, lactic acid bacteria, Bacillus, saccharomycete, the liquid fermentation training after the corresponding sterilizing of access Support in base, cultivating 48-96h in 24-38 DEG C obtains zymotic fluid;
3)Prepare probiotics and its metabolite
Corresponding bacterium mud is obtained after probiotics fermention liquid is centrifuged, carrier is then added and is freeze-dried, it is ensured that be living after drying The quantity of bacterium is in certain valid value range, and fermented supernatant fluid after centrifugation carries out being lotion after cryogenic vacuum concentration, by with Upper method respectively obtains probiotics and dries viable bacteria powder and supernatant cream mud;
Or, it is that probiotics fermention liquid is directly carried out to cryogenic vacuum to concentrate to be cream mud;
4)Prepare Chinese herbal medicine tunning
By Chinese herbal medicine after ultramicro grinding is handled, the fermentation rich in Chinese herbal medicine effective ingredientses is obtained after probiotics fermention and is produced Thing, is then prepared into Chinese recipe mud;
5)Preparation can carry out the preparation of atomized medicine introducing
Probiotics and its metabolite are pressed one with the one or more in Chinese herbal medicine tunning, respiratory mucosa reparative factor Certainty ratio, which is mixed with, can carry out the preparation of atomized medicine introducing;
6)Prepare orally available preparation
By probiotics and its metabolite and Chinese herbal medicine tunning, respiratory mucosa reparative factor, intestinal mucosa reparative factor In one or more be mixed with orally available preparation by a certain percentage;
7)Compatibility is combined with quantitative prebiotics.
2. the production method according to claim 1 for preventing and treating livestock and birds respiratory disease product, it is characterised in that Described probiotics fermention liquid is through 3000-6000r/min × 5-20min centrifugal treatings.
3. the production method according to claim 1 for preventing and treating livestock and birds respiratory disease product, it is characterised in that Described Chinese herbal medicine uses all Chinese herbal medicines effective to treatment breathing problem, includes but is not limited to:Radix Isatidis, gypsum, The dried rhizome of rehmannia, balloonflower root, the coptis, radix scutellariae, cape jasmine, radix scrophulariae, the capsule of weeping forsythia, two flowers, safflower, rheum officinale, saltcake, radix glycyrrhizae, close cape jasmine, honeysuckle, scold Son, caulis bambusae in taenian, golden cypress, the root of herbaceous peony, gypsum, saltcake, folium isatidis, Radix Et Rhizoma Rhei, perillaseed, gingko, almond, double skins, tussilago, Chinese ephedra, Cordate houttuynia, ginseng, ganoderma lucidum, honeysuckle, schizonepeta, windproof, cassia twig, loguat leaf, old tea, Plant Soot, the wind-weed, fritillaria, balloonflower root, mulberry Skin, loguat leaf, lepidium seed, the tuber of dwarf lilyturf, alstonia-leaf, Rajmahal creeper, cacumen biotae, boenninghausenia sessilicarpa, pappy shell, Verbena officinalis, kuh-seng, the tuber of pinellia, Cape jasmine Son, Radix Angelicae Sinensis, the achene of Siberian cocklebur, the bighead atractylodes rhizome, injustice silk, radix bupleuri, fructus psoaleae, dried orange peel.
4. the production method according to claim 1 for preventing and treating livestock and birds respiratory disease product, it is characterised in that Fineness after described Chinese herbal medicine ultra-fine powder is broken is between 100-6000 mesh.
5. the production method according to claim 1 for preventing and treating livestock and birds respiratory disease product, it is characterised in that Described Chinese herbal medicine probiotics fermention mode is divided into solid fermentation and liquid fermentation.
6. the production method according to claim 5 for preventing and treating livestock and birds respiratory disease product, it is characterised in that The mode of described solid fermentation is divided into aerobic after aerobic fermentation, first anaerobic fermentation, aerobic rear anaerobism or first anaerobism.
7. the production method according to claim 5 for preventing and treating livestock and birds respiratory disease product, it is characterised in that Described liquid fermentation is will to add quantitative bacteria culture media after Chinese herbal medicine micro mist to access corresponding benefit after high-temperature sterilization Raw bacterium strain carries out aerobic or anaerobic fermentation.
8. the production method according to claim 1 for preventing and treating livestock and birds respiratory disease product, it is characterised in that Described respiratory mucosa reparative factor can answer the material of respiratory tract, including but not limited to EGF using all.
9. the production method according to claim 1 for preventing and treating livestock and birds respiratory disease product, it is characterised in that Described intestinal mucosa reparative factor can repair the material of enteron aisle, including but not limited to EGF using all.
10. the production method according to claim 1 for preventing and treating livestock and birds respiratory disease product, its feature exists In described prebiotics is oligosaccharide, polysaccharide, vegetable Chinese herbal medicine extract, protein hydrolysate or polyalcohol.
CN201710427501.1A 2017-06-08 2017-06-08 A kind of production method for preventing and treating livestock and birds respiratory disease product Pending CN107007640A (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109043159A (en) * 2018-08-24 2018-12-21 广东群林牧业有限公司 A kind of internal expelling parasite ewe feed formulation method
CN111034855A (en) * 2019-12-31 2020-04-21 山西大禹生物工程股份有限公司 Composition for enhancing respiratory tract immunity of animals, method and application thereof
CN111388527A (en) * 2020-04-10 2020-07-10 聊城创新畜禽养殖有限公司 Preparation for preventing and treating mycoplasma of laying hens and preparation method thereof
CN112618620A (en) * 2020-07-20 2021-04-09 六安恒佳生物科技有限公司 Solid-state fermentation traditional Chinese medicine additive for controlling respiratory diseases of laying fowls and preparation method thereof
CN114099590A (en) * 2021-11-02 2022-03-01 江西新天地药业有限公司 Fermented Chinese herbal medicine preparation for preventing and treating livestock and poultry diarrhea and preparation method thereof
CN116585370A (en) * 2023-03-21 2023-08-15 上海交通大学医学院附属第九人民医院 Traditional Chinese medicine composition and application thereof in preparation of medicine for treating/preventing acute upper respiratory tract infection

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CN102805209A (en) * 2012-08-30 2012-12-05 湖南省微生物研究所 Synbiotics feed additive for beasts and birds and application thereof
CN103704483A (en) * 2013-12-31 2014-04-09 株洲千金药业股份有限公司 Feed fermented by utilizing traditional Chinese medicine drugs and preparation method of feed

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Publication number Priority date Publication date Assignee Title
CN102805209A (en) * 2012-08-30 2012-12-05 湖南省微生物研究所 Synbiotics feed additive for beasts and birds and application thereof
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109043159A (en) * 2018-08-24 2018-12-21 广东群林牧业有限公司 A kind of internal expelling parasite ewe feed formulation method
CN111034855A (en) * 2019-12-31 2020-04-21 山西大禹生物工程股份有限公司 Composition for enhancing respiratory tract immunity of animals, method and application thereof
CN111388527A (en) * 2020-04-10 2020-07-10 聊城创新畜禽养殖有限公司 Preparation for preventing and treating mycoplasma of laying hens and preparation method thereof
CN112618620A (en) * 2020-07-20 2021-04-09 六安恒佳生物科技有限公司 Solid-state fermentation traditional Chinese medicine additive for controlling respiratory diseases of laying fowls and preparation method thereof
CN114099590A (en) * 2021-11-02 2022-03-01 江西新天地药业有限公司 Fermented Chinese herbal medicine preparation for preventing and treating livestock and poultry diarrhea and preparation method thereof
CN116585370A (en) * 2023-03-21 2023-08-15 上海交通大学医学院附属第九人民医院 Traditional Chinese medicine composition and application thereof in preparation of medicine for treating/preventing acute upper respiratory tract infection

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