CN105724770A - Chinese herbal medicine nanometer feed additive and preparing method and application thereof - Google Patents

Chinese herbal medicine nanometer feed additive and preparing method and application thereof Download PDF

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CN105724770A
CN105724770A CN201610076297.9A CN201610076297A CN105724770A CN 105724770 A CN105724770 A CN 105724770A CN 201610076297 A CN201610076297 A CN 201610076297A CN 105724770 A CN105724770 A CN 105724770A
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chinese herbal
herbal medicine
parts
raw material
medicine feed
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胡永灵
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315Isatis, e.g. Dyer's woad
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    • A61K36/35Caprifoliaceae (Honeysuckle family)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634Forsythia
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/78Saururaceae (Lizard's-tail family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/85Verbenaceae (Verbena family)
    • A61K36/855Clerodendrum, e.g. glorybower
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00Lactic or propionic acid bacteria
    • A23V2400/11Lactobacillus
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/19Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment

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Abstract

The invention relates to a Chinese herbal medicine nanometer feed additive, and a preparing method and application thereof.The Chinese herbal medicine nanometer feed additive is prepared from folium artemisiae argyi, ginger, hawthorn fruit, astragalus membranaceus, honeysuckle flowers, fructus forsythiae, folium isatidis, great burdock achene, purslane, houttuynia cordata, common yam rhizome and polygonum multiflorum.The preparing method mainly comprises the biological fermentation technology and the nanometer wall-breaking technology.Chinese herbal medicinal ingredients are adopted as the main raw materials of the Chinese herbal medicine nanometer feed additive, the side effect is small, the situation that pathogenic microorganisms in the organism generate tolerance and drug resistance can not be caused easily, drug residues in the animal bodies are avoided, and animal food safety is guaranteed.According to the method, bitterness and impetuosity of the raw materials can be removed, and availability of active ingredients in traditional Chinese medicine and speed of drug action are increased.

Description

A kind of Chinese herbal medicine feed nano additive, its preparation method and application
Technical field
Present invention relates particularly to a kind of Chinese herbal medicine feed nano additive, its preparation method and application.
Background technology
The feed additive of existing disease-resistant growth-promoting is mainly antibiotic and chemicals additive, also more useful Chinese herbal medicine additive.The shortcoming of antibiotic and chemicals class additive is that life-time service side effect is very big, pathogenic microorganism can be caused to develop immunity to drugs on the one hand, reduce the effect of medical treatment Animal diseases: be excessively used antibiotic on the other hand and chemicals additive can cause drug residue in meat, egg, milk and environment, thus serious threat human life is healthy.For this, antibiotic and chemicals additive should be used as restriction and the regulation being phased out or disabling by world many countries.Chinese herbal medicine immunity substance mass-energy enhancing human body immunity function, improves animal anti-stress, resistance against diseases, improves growth of animal performance, have noresidue, be not likely to produce the advantages such as drug resistance, be the focus of animal nutrition research in recent years.
Present inventor is when using existing Chinese herbal medicine additive, it has been found that there is problems in that
1, the component unreasonable allocation of existing Chinese herbal medicine additive, is not so good as antibiotic and chemicals additive to the income of the disease-resistant growth-promoting of animal, causes that raiser is more willing to use antibiotic and chemicals additive.
2, existing Chinese herbal medicine additive often uses simple machining or boiling method effective component extracting, active component in Chinese herbal medicine cell can not be fully extracted, cause the significant wastage of Chinese herbal medicine on the one hand, medicine functioning efficiency is very low with speed on the other hand, it is impossible to reach drug efficiency and the speed of antibiotic and chemicals additive.
3, existing Chinese herbal medicine additive often contains bigger bitterness, have impact on the palatability of feedstuff after mixing in feedstuff, reduces the diet desire of animal, thus the economic well-being of workers and staff of raiser is had undesirable effect.
Summary of the invention
In order to solve the problems referred to above that prior art exists, the invention provides a kind of Chinese herbal medicine feed nano additive, its preparation method and application.Described Chinese herbal medicine feed nano additive can increase the growth rate of animal and reduce the sickness rate of animal;Described preparation method can improve functioning efficiency and the speed of the active component in Chinese medicine, and decreases drug waste, improves culture benefit.
The technical solution adopted in the present invention is: a kind of Chinese herbal medicine feed nano additive, makes including following raw material: Folium Artemisiae Argyi, Rhizoma Zingiberis Recens, Fructus Crataegi, the Radix Astragali, Flos Lonicerae, Fructus Forsythiae, Folium Isatidis, Fructus Arctii, Herba Portulacae, Herba Houttuyniae, Rhizoma Dioscoreae, Radix Polygoni Multiflori.
Described Chinese herbal medicine feed nano additive, it is that present inventor is according to the growth of animal, life habit, draw through scientific compatibility, repetition test, it is possible to increase the Oestrus rate of animal, farrowing rate, rate of body weight gain and rate of giving milk, and then add the income of raiser;Meanwhile, described Chinese herbal medicine feed nano additive can reduce the sickness rate of animal, thus reducing antibiotic use in animal body.Ensure the safety of animal food.
For improving the effect of described Chinese herbal medicine feed nano additive further, preferred technical scheme is, the weight portion of described raw material is: Folium Artemisiae Argyi 5-10 part, Rhizoma Zingiberis Recens 3-7 part, Fructus Crataegi 4-9 part, Radix Astragali 6-10 part, Flos Lonicerae 2-8 part, Fructus Forsythiae 3-5 part, Folium Isatidis 4-10 part, Fructus Arctii 6-12 part, Herba Portulacae 3-9 part, Herba Houttuyniae 5-10 part, Rhizoma Dioscoreae 10-16 part, Radix Polygoni Multiflori 2-4 part.
Further, the weight portion of described raw material is: Folium Artemisiae Argyi 7 parts, 5 parts of Rhizoma Zingiberis Recens, Fructus Crataegi 6 parts, the Radix Astragali 8 parts, Flos Lonicerae 5 parts, Fructus Forsythiae 4 parts, Folium Isatidis 7 parts, Fructus Arctii 9 parts, Herba Portulacae 6 parts, Herba Houttuyniae 7 parts, Rhizoma Dioscoreae 13 parts, Radix Polygoni Multiflori 3 parts.
In the present invention, if not refering in particular to, all of part, percentage ratio are unit of weight, and all of equipment and raw material etc. all can be buied from market or the industry is conventional.Method in following embodiment, if no special instructions, is the conventional method of this area.
In order to explain the present invention better, below the raw material in the present invention and compatibility relationship are further elaborated.
Folium Artemisiae Argyi, Chinese medicine name, the dried leaves of the ArtemisiaargyiLevl.etVant. that ends for feverfew.Harvesting when summer, flower was not opened, removes impurity, dries.Folium Artemisiae Argyi gas delicate fragrance, bitter in the mouth.There is effect of dispersing cold for relieving pain and removing dampness to relieve itching.
Rhizoma Zingiberis Recens, Chinese medicine name, is the fresh rhizome of Zingiberaceae herbaceos perennial Rhizoma Zingiberis Recens.Rhizoma Zingiberis Recens has effect of induce sweat cold expelling and warming the lung removing toxic substances.
Fructus Crataegi, Chinese medicine name, for the dry mature fruit of rosaceous plant Fructus Pyri Pashiae Crataeguspin, natiidaBge.var.majorN.E.Br. or Fructus Crataegi Crataeguspin.natifidaBge..Gather during fruit maturation in autumn, section, dry.Fructus Crataegi has promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis and changes effect of turbid blood fat reducing.
The Radix Astragali, formal name used at school Astragalusmembranaceus (Fisch.) Bunge, it has enhancing human body immunity function, protects the liver anti-stress and wide antibacterial action.
Flos Lonicerae, has another name called Radix Ophiopogonis, formal name used at school Lonicerajaponica;Flos Lonicerae sweet in the mouth fragrant odour cold in nature, clearing away heat with drugs sweet in flavor and cold in nature and do not injure one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae has effect of dispelling wind-heat, heat-clearing and toxic substances removing and sterilization.
Fructus Forsythiae, formal name used at school Forsythiasuspensa;Fructus Forsythiae has effect of heat-clearing and toxic substances removing and mass dissipating and swelling eliminating.
Folium Isatidis, Chinese medicine name, there is effect of heat-clearing and toxic substances removing and blood cooling and ecchymoses removing.
Fructus Arctii, the dry mature fruit of Chinese medicine Compositae biennial herb plant Fructus Arctii by name.Fructus Arctii has dispelling wind and heat pathogens, lung qi dispersing sore-throat relieving, removing toxic substances rash and detumescence and treats effect of skin ulcer.
Herba Portulacae, Chinese medicine name, for Portulacaceae annual herb plant.Herba Portulacae herb hyoscine, has clearing away heat-damp and promoting diuresis, effect that removing toxic substances and promoting subsidence of swelling, antiinflammatory are quenched the thirst.
Herba Houttuyniae, Chinese medicine name, have another name called Herba Houttuyniae, for the dry aerial parts of saururaceae plant houttuynia cordata.Herba Houttuyniae has effect of heat-clearing and toxic substances removing, promoting urination to remove dampness, clearing away heat to cure dysentery and invigorating the stomach and promoting digestion.
Rhizoma Dioscoreae, formal name used at school CommonYamRhizome, RhizomeofCommonYam, Dioscoreaerhizoma;Rhizoma Dioscoreae has the effect nourishing strong, aid digestion and antidiarrheal,
Radix Polygoni Multiflori, formal name used at school Fallopiamultiflora (Thunb.) Harald.;Effect that Radix Polygoni Multiflori has loosening bowel to relieve constipation, preventing the attack (or recurrence) of malaria dispels the wind and detoxifies.
Above raw material and compatibility relationship thereof, it is that present inventor is through concentrating on studies, puzzle out and obtain, utilize cold expelling effect of Folium Artemisiae Argyi and Rhizoma Zingiberis Recens, mediation animal body constitution, Radix Astragali gold conjugate Flos Lonicerae can strengthen the immunity of described animal while sterilizing, it is aided with the heat-clearing and toxic substances removing of Fructus Forsythiae, Folium Isatidis, Fructus Arctii, Herba Portulacae, Herba Houttuyniae and Radix Polygoni Multiflori, invigorating the stomach and promoting digestion plus Fructus Crataegi, Herba Houttuyniae and Rhizoma Dioscoreae, add the loosening bowel to relieve constipation of Radix Polygoni Multiflori, it is finally reached the metabolic function strengthening animal, the effect of the growth rate increasing animal the sickness rate reducing animal.
The preparation method that present invention also offers a kind of described Chinese herbal medicine feed nano additive, comprises the following steps:
A, Folium Artemisiae Argyi, Folium Isatidis, Herba Portulacae and Herba Houttuyniae are separately added into active bacteria formulation carry out classification biofermentation;
B, will mix homogeneously with all the other raw materials through the Folium Artemisiae Argyi of biofermentation, Folium Isatidis, Herba Portulacae and Herba Houttuyniae;
C, the raw material of mix homogeneously is made nanometer technology for broken wall process, and make granule.
In described preparation method, adopt active bacteria formulation that raw material carries out fermentation process, remove raw material itself bitterness, strong while, reduction toxic and side effects, to improve the palatability of described Chinese herbal medicine feed nano additive.
In step C, raw material doing a nanometer broken wall treatment, is broken completely by the cell wall of raw material so that the medicine matter in raw material all exposes, diameter of aspirin particle reaches nanometer, can enter in focus cell, improves functioning efficiency and the speed of Chinese medicine.
Preferably, the active bacteria formulation in step A includes one or more in lactic acid bacteria, yeast and bacillus subtilis.The advantage that lactic acid bacteria, yeast and bacillus subtilis all have biological activity height, fermentation efficiency is high, sweat is gentle.
Preferably, whole raw materials adding in step B three-dimensional mixing machine and fully mixes, the speed of agitator of three-dimensional mixing machine is 20-200 rev/min, and mixing time is 1-3 hour.Use three-dimensional mixing machine, it is possible to be sufficiently mixed uniformly by raw material, be placed in the setting of duration and time, be that present inventor specifies according to the characteristic of raw material, under these conditions, it is possible to ensure that raw material is thoroughly mixed uniformly.
Preferably, after raw material mix homogeneously, high-temperature steam being used to carry out sterilization treatment described raw material in step B, the temperature of described high-temperature steam is 105-115 DEG C, and sterilization time is 20-30 minute.After sterilized process, the antibacterial in raw material is killed, and adds the holding time of finished product.
Additionally, it is destroyed for reducing the active component in raw material as far as possible, in the present invention and be generally capable of up to 125 DEG C of non-selected high-temperature steam, but adopts 105-115 DEG C, and the method for proper extension sterilization time reaches identical sterilization effect, reduce the loss of active component simultaneously.
Preferably, the use nano-pulverization equipment in step C, described raw material particle diameter after multiple fractionation is pulverized is 5-10 μm.Multiple fractionation pulverizes the uniformity that ensure that final grain diameter, also saves energy consumption.Described particle diameter can enter in focus cell, improves the advantage such as functioning efficiency and speed of Chinese medicine.
The invention also discloses the application in preparing feedstuff of the described Chinese herbal medicine feed nano additive, in general, described Chinese herbal medicine feed nano additive percentage by weight in feedstuff is 0.1-2%.Certainly, those skilled in the art according to practical situation, can make different content and select, just repeat no more at this.
The invention have the benefit that
1, the invention provides a kind of Chinese herbal medicine feed nano additive, described Chinese herbal medicine feed nano additive primary raw material is Chinese medicine ingredients, and side effect is little, not easily causes pathogenic microorganism to produce drug resistance and Drug resistance, will not cause drug residue in animal body simultaneously.
2, the Chinese herbal medicine feed nano additive in the present invention, adopts 12 kinds of Chinese medicines to cooperate, it is possible to increase the Oestrus rate of animal, farrowing rate, rate of body weight gain and rate of giving milk;Meanwhile, described Chinese herbal medicine feed nano additive can reduce the sickness rate of animal, thus reducing antibiotic effect in animal body.There are significantly high economic benefit and ecological benefits.
3, the Chinese herbal medicine feed nano additive in the present invention, more conventional Antibiotic Additive can improve oestrus of sow rate 57%, sow fertility rate 22%, growing and fattening pigs daily gain 6.6%, milch cow rate of giving milk 20%, mammitis of cow sickness rate 98.2% can be reduced.
4, the preparation method that present invention also offers a kind of described Chinese herbal medicine feed nano additive, adopt active bacteria formulation that raw material is carried out biological engineering fermentation process, remove raw material itself bitterness, strong while, reduction toxic and side effects, to improve the palatability of described Chinese herbal medicine feed nano additive;Raw material is done broken wall treatment, the cell wall of raw material is broken completely so that the medicine matter in raw material all exposes, improve the advantage such as functioning efficiency and speed of Chinese medicine.
Detailed description of the invention
Below in conjunction with embodiment, further illustrate present disclosure.Should be appreciated that the enforcement of the present invention is not limited to the following examples, any pro forma accommodation and/or change that the present invention is made fall within scope.
In the present invention, if not refering in particular to, all of part, percentage ratio are unit of weight, and all of equipment and raw material etc. all can be buied from market or the industry is conventional.Method in following embodiment, if no special instructions, is the conventional method of this area.
Embodiment 1
A kind of Chinese herbal medicine feed nano additive, the raw material including following weight is made: Folium Artemisiae Argyi 5g, Rhizoma Zingiberis Recens 7g, Fructus Crataegi 4g, Radix Astragali 10g, Flos Lonicerae 2g, Fructus Forsythiae 5g, Folium Isatidis 4g, Fructus Arctii 12g, Herba Portulacae 3g, Herba Houttuyniae 10g, Rhizoma Dioscoreae 10g, Radix Polygoni Multiflori 4g.
The preparation method that the present embodiment additionally provides a kind of described Chinese herbal medicine feed nano additive, comprises the following steps:
A, Folium Artemisiae Argyi, Folium Isatidis, Herba Portulacae and Herba Houttuyniae are separately added into active bacteria formulation carry out classification biofermentation;Described active bacteria formulation includes lactic acid bacteria and yeast;
B, fully mixing adding three-dimensional mixing machine according to the above ratio through the Folium Artemisiae Argyi of biofermentation, Folium Isatidis, Herba Portulacae and Herba Houttuyniae and all the other raw materials, the speed of agitator of three-dimensional mixing machine is 20 revs/min, and mixing time is 3 hours;After raw material mix homogeneously, using high-temperature steam to carry out sterilization treatment described raw material, the temperature of described high-temperature steam is 105 DEG C, and sterilization time is 30 minutes;
C, the raw material of mix homogeneously using nano-pulverization equipment make nanometer broken wall treatment, described raw material particle diameter after multiple fractionation is pulverized is 5 μm, and makes granule.
The present embodiment also discloses the application in preparing feedstuff of the described Chinese herbal medicine feed nano additive, and described Chinese herbal medicine feed nano additive percentage by weight in feedstuff is 2%.
Embodiment 2
A kind of Chinese herbal medicine feed nano additive, the raw material including following weight is made: Folium Artemisiae Argyi 10g, Rhizoma Zingiberis Recens 3g, Fructus Crataegi 9g, Radix Astragali 6g, Flos Lonicerae 8g, Fructus Forsythiae 3g, Folium Isatidis 10g, Fructus Arctii 6g, Herba Portulacae 9g, Herba Houttuyniae 5g, Rhizoma Dioscoreae 16g, Radix Polygoni Multiflori 2g.
The preparation method that the present embodiment additionally provides a kind of described Chinese herbal medicine feed nano additive, comprises the following steps:
A, Folium Artemisiae Argyi, Folium Isatidis, Herba Portulacae and Herba Houttuyniae are separately added into active bacteria formulation carry out classification biofermentation;Described active bacteria formulation includes yeast;
B, fully mixing adding three-dimensional mixing machine according to the above ratio through the Folium Artemisiae Argyi of biofermentation, Folium Isatidis, Herba Portulacae and Herba Houttuyniae and all the other raw materials, the speed of agitator of three-dimensional mixing machine is 200 revs/min, and mixing time is 1 hour;After raw material mix homogeneously, using high-temperature steam to carry out sterilization treatment described raw material, the temperature of described high-temperature steam is 115 DEG C, and sterilization time is 20 minutes;
C, the raw material of mix homogeneously using nano-pulverization equipment make nanometer broken wall treatment, described raw material particle diameter after multiple fractionation is pulverized is 10 μm, and makes granule.
The present embodiment also discloses the application in preparing feedstuff of the described Chinese herbal medicine feed nano additive, and described Chinese herbal medicine feed nano additive percentage by weight in feedstuff is 0.1%.
Embodiment 3
A kind of Chinese herbal medicine feed nano additive, the raw material including following weight is made: Folium Artemisiae Argyi 7g, Rhizoma Zingiberis Recens 5g, Fructus Crataegi 6g, Radix Astragali 8g, Flos Lonicerae 5g, Fructus Forsythiae 4g, Folium Isatidis 7g, Fructus Arctii 9g, Herba Portulacae 6g, Herba Houttuyniae 7g, Rhizoma Dioscoreae 13g, Radix Polygoni Multiflori 3g.
The preparation method that the present embodiment additionally provides a kind of described Chinese herbal medicine feed nano additive, comprises the following steps:
A, Folium Artemisiae Argyi, Folium Isatidis, Herba Portulacae and Herba Houttuyniae are separately added into active bacteria formulation carry out classification biofermentation;Described active bacteria formulation includes lactic acid bacteria, yeast and bacillus subtilis;
B, fully mixing adding three-dimensional mixing machine according to the above ratio through the Folium Artemisiae Argyi of biofermentation, Folium Isatidis, Herba Portulacae and Herba Houttuyniae and all the other raw materials, the speed of agitator of three-dimensional mixing machine is 110 revs/min, and mixing time is 2 hours;After raw material mix homogeneously, using high-temperature steam to carry out sterilization treatment described raw material, the temperature of described high-temperature steam is 110 DEG C, and sterilization time is 25 minutes;
C, the raw material of mix homogeneously using nano-pulverization equipment make nanometer broken wall treatment, described raw material particle diameter after multiple fractionation is pulverized is 7 μm, and makes granule.
The present embodiment also discloses the application in preparing feedstuff of the described Chinese herbal medicine feed nano additive, and described Chinese herbal medicine feed nano additive percentage by weight in feedstuff is 1%.
The feeding trial below done for the Chinese herbal medicine feed nano additive in the present invention.
Test example 1
Select the Holstein cow that 400 the first-borns are secondary, milk yield is close, be randomly divided into matched group and 2 groups of experimental group, often group 200.
Matched group feeding normal diet, the feedstuff adding described Chinese herbal medicine feed nano additive that experimental group feeding obtains according to the ratio of embodiment 3.For the fixing groove position of examination cattle, feed every day 3 times, 3 mechanical milkings, and add up milk yield.
Concrete outcome asks for an interview table 1
Table 1 experimental group and matched group cow producing milk Performance comparision table
From upper table it can be seen that the average daily milk production of experimental group is apparently higher than matched group, prevalence is significantly lower than matched group simultaneously, while the rate of giving milk that the Chinese herbal medicine feed nano additive in the present invention can significantly improve milch cow is described, reduces sickness rate.
Test example 2
Select about 10 kilograms pigletss 200, after child care transition in 10 days, be randomly divided into matched group and 2 groups of experimental group, often group 100.
Matched group feeding normal diet, the feedstuff adding described Chinese herbal medicine feed nano additive that experimental group feeding obtains according to the ratio of embodiment 3.When breeding environment is consistent, raise 120 days.After 120 days, add up piglets body weight.
Concrete outcome asks for an interview table 2
Table 2 experimental group and matched group daily gain compare
From upper table it can be seen that the average daily gain of experimental group is apparently higher than matched group, prevalence is significantly lower than matched group simultaneously, illustrates that the Chinese herbal medicine feed nano additive in the present invention can significantly improve the daily gain of piglets, reduces sickness rate simultaneously.
It should be noted last that; above example is only in order to illustrate technical scheme and unrestricted; although the present invention being described in detail with reference to preferred embodiment; it is it should be understood that; the foregoing is only the specific embodiment of the present invention, the protection domain being not intended to limit the present invention, all within the spirit and principles in the present invention; any amendment of being made, equivalent replacement, improvement etc., should be included within protection scope of the present invention.

Claims (10)

1. a Chinese herbal medicine feed nano additive, it is characterised in that include following raw material and make: Folium Artemisiae Argyi, Rhizoma Zingiberis Recens, Fructus Crataegi, the Radix Astragali, Flos Lonicerae, Fructus Forsythiae, Folium Isatidis, Fructus Arctii, Herba Portulacae, Herba Houttuyniae, Rhizoma Dioscoreae, Radix Polygoni Multiflori.
2. Chinese herbal medicine feed nano additive according to claim 1, it is characterized in that, the weight portion of described raw material is: Folium Artemisiae Argyi 5-10 part, Rhizoma Zingiberis Recens 3-7 part, Fructus Crataegi 4-9 part, Radix Astragali 6-10 part, Flos Lonicerae 2-8 part, Fructus Forsythiae 3-5 part, Folium Isatidis 4-10 part, Fructus Arctii 6-12 part, Herba Portulacae 3-9 part, Herba Houttuyniae 5-10 part, Rhizoma Dioscoreae 10-16 part, Radix Polygoni Multiflori 2-4 part.
3. Chinese herbal medicine feed nano additive according to claim 1, it is characterized in that, the weight portion of described raw material is: Folium Artemisiae Argyi 7 parts, 5 parts of Rhizoma Zingiberis Recens, Fructus Crataegi 6 parts, the Radix Astragali 8 parts, Flos Lonicerae 5 parts, Fructus Forsythiae 4 parts, Folium Isatidis 7 parts, Fructus Arctii 9 parts, Herba Portulacae 6 parts, Herba Houttuyniae 7 parts, Rhizoma Dioscoreae 13 parts, Radix Polygoni Multiflori 3 parts.
4. the preparation method of the arbitrary described Chinese herbal medicine feed nano additive of claim 1-3, it is characterised in that comprise the following steps:
A, Folium Artemisiae Argyi, Folium Isatidis, Herba Portulacae and Herba Houttuyniae are separately added into active bacteria formulation carry out classification biofermentation;
B, will mix homogeneously with all the other raw materials through the Folium Artemisiae Argyi of biofermentation, Folium Isatidis, Herba Portulacae and Herba Houttuyniae;
C, the raw material of mix homogeneously is made nanometer technology for broken wall process, and make granule.
5. preparation method according to claim 4, it is characterised in that the active bacteria formulation in step A includes one or more in lactic acid bacteria, yeast and bacillus subtilis.
6. preparation method according to claim 4, it is characterised in that whole raw materials adding in step B three-dimensional mixing machine and fully mixes, the speed of agitator of three-dimensional mixing machine is 20-200 rev/min, and mixing time is 1-3 hour.
7. preparation method according to claim 4, it is characterised in that after raw material mix homogeneously, high-temperature steam being used to carry out sterilization treatment described raw material in step B, the temperature of described high-temperature steam is 105-115 DEG C, and sterilization time is 20-30 minute.
8. preparation method according to claim 4, it is characterised in that the use nano-pulverization equipment in step C, described raw material particle diameter after multiple fractionation is pulverized is 5-10 μm.
9. claim 1-3 arbitrary described Chinese herbal medicine feed nano additive application in preparing feedstuff.
10. application according to claim 9, described Chinese herbal medicine feed nano additive percentage by weight in feedstuff is 0.1-2%.
CN201610076297.9A 2016-02-03 2016-02-03 Chinese herbal medicine nanometer feed additive and preparing method and application thereof Pending CN105724770A (en)

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