KR101771521B1 - Method of preparing oriental medicine composition for treating thyroid diseases - Google Patents

Abstract

The present invention provides a method for preparing an oriental medicine composition for treating thyroid diseases containing Cervus elaphus which has high absorption rate of the active ingredient to a human body and increases human metabolism by separating and fermenting constituents of deer antlers and the like capable of treating or alleviating various symptoms shown in thyroid diseases such as hypothyroidism, and the like according to the characteristics of the constituents. The present invention comprises the following steps: fermenting Rehmannia glutinosa, Angelica gigas, Paeonia japonica, Dioscorea polystachya, Atractylodes japonica, Paeonia suffruticosa, Cinnamomum cassia, Lycium chinense, Cyperus rotundus, Citrus aurantium, Cuscuta chinensis, Uncaria rhynchophylla, and Ganoderma lucidum and pulverizing the same to prepare a fermented powdery medicinal material (A); fermenting Cervus elaphus, Holothuroidea, and Prunus dulcis with an EM fermentation solution, and pulverizing the same to prepare a fermented powdery medicinal material (B); and mixing the fermented powdery medicinal material (A) and the fermented powdery medicinal material (B) at a predetermined ratio.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a method for preparing a medicinal herbal composition for treating thyroid disease,

The present invention relates to a method for manufacturing a herbal composition for treating thyroid disease, including deer antler, and more particularly, to a method for manufacturing a herbal composition for treating thyroid disease, including antler thrush, The present invention relates to a method for producing a herbal composition which has high absorption rate of the active ingredient and increases the metabolism amount of the human body by fermentation according to the characteristics of the ingredients.

The thyroid is a small endocrine organ with a butterfly shape located below the neck. It weighs about 30 grams, but it is very important to work in the human body in terms of weight and size. It is a factory that produces T3 and T4 thyroid hormones according to the brain's command. The thyroid gland is important for everyone, but especially for women.

More than 80% of all thyroid disease patients are women and they are directly or indirectly related to the health of women including physiology, pregnancy and childbirth, weight control, poor circulation, depression, hair loss, constipation and diarrhea, edema, skin problems, It is deeply involved.

A typical thyroid disease is hypothyroidism. The most characteristic symptom of hypothyroidism is fatigue. In addition, the body is usually weak, dry skin, often cold, symptoms such as cold, hair loss, loss of concentration, memory impairment, constipation may also appear. Also, appetite decreases, but weight gain, dyspnea and hoarse voice are characteristic. In women, menstrual hyperplasia occurs early and menstruation and lightweight menstruation are reduced in later stages. Symptoms such as an abnormal sensation or hearing loss may also occur.

These hypothyroidism hypothyroidism can be divided into primary thyroid dysfunction due to thyroid itself and secondary hypothyroidism due to abnormalities of the organ called pituitary gland that secretes hormones that regulate the thyroid gland.

The most common disease of primary hypothyroidism is chronic autoimmune thyroiditis (Hashimoto's thyroiditis). In addition, to treat other diseases of the thyroid gland, surgery can remove the thyroid gland, or if the thyroid is destroyed by radioiodine treatment, Lt; / RTI >

Very rarely, there are congenital hypothyroidism, which is born with no birth thyroid gland or problems with the production process of thyroid hormone. Temporal hypothyroidism may be the cause of hypothyroidism, or it may recover to normal thyroid function by itself. The most common is thyroid dysfunction, hypothyroidism to treat hyperthyroidism during the temporary hypothyroidism, or iodine deficiency or overdose due to hypothyroidism occurs when the hypothyroidism.

Iodine is abundantly contained in seaweeds. In Korea, recently, hypothyroidism has occurred temporarily after ingesting health food containing seaweed as a main ingredient. In addition, subacute thyroiditis due to viral infection or postpartum thyroiditis temporarily hypothyroidism during the course of the hypothyroidism, but mostly recovered by itself.

Secondary hypothyroidism is caused by pituitary gland tumors, pituitary glands, pituitary gland injury due to radiation therapy, pituitary dysfunction due to excessive bleeding during childbirth (hypotony syndrome), hypothyroidism, hypothyroidism, hypothyroidism TSH) is not secreted. Therefore, most of the symptoms are accompanied by deficiency symptoms of other hormones secreted from the pituitary gland.

Over 95% of hypothyroidism is primary hypothyroidism and 70 ~ 85% of primary hypothyroidism is due to chronic autoimmune thyroiditis. Chronic autoimmune thyroiditis (Hashimoto thyroiditis) is a chronic inflammatory disease in which an autoimmune reaction occurs in the thyroid gland, which is a part of our body, and an autoantibody is made so that inflammatory cells such as lymphocytes collect in the thyroid gland to gradually destroy the thyroid gland cells.

Hashimoto's first name was found in Japan, so it is called Hashimoto thyroiditis after his name. Autoimmunity is a phenomenon in which human immune cells that react to external influences, such as bacterial infections or other organ transplants, attack the body inappropriately. There are many hypotheses about why an immune response occurs to the thyroid gland, but nothing is known yet.

It is known that 95% of the patients are female, and there are quite a lot of patients with thyroid diseases as well as other thyroid diseases and genetic tendency. Hashimoto's thyroiditis varies greatly depending on stage and severity of illness. Thyroid tumors can range from small to thick to very large and hard, ranging from normal to severe hypothyroidism.

Even if some of the thyroid cells are destroyed, they make more hormones in the remaining thyroid cells, and compensatory action such as enlargement of the thyroid gland causes the thyroid hormone necessary for the body to be maintained.

Such thyroid disease, especially hypothyroidism, is a disease in which the rate of digestion is lowered as the metabolism is lowered, so even if taking the thyroid gland or antiloid, the digestive dysfunction is still easy to complain.

Therefore, there is a need to develop a herbal medicine composition which is capable of activating the metabolism of human body such as digestion function while treating or alleviating the thyroid disease without side effects on the human body.

Korean Patent No. 10-1621446

The present invention has been conceived to solve the above problems, and it is an object of the present invention to provide a composition for preventing or treating various symptoms that may occur in thyroid diseases such as hypothyroidism, The present invention provides a method for manufacturing a herbal composition for treating thyroid disease, which comprises deer fermentation, which increases the body absorption rate of the active ingredient and increases the metabolism amount of the human body.

In order to accomplish the above object, the present invention provides a method for preparing a herbal composition for treating thyroid disease, comprising the steps of: preparing a herbal medicine composition for treating thyroid disease, (A) was prepared by mixing EM fermented broth (A), herbal supplements, crustaceans, algae, zucchini, and Ganoderma lucidum in a weight ratio of 1: 1: 1: 1: 1: 1: 2: 2: 2: And the resulting mixture was fermented at room temperature for 48 hours, and was then steamed with steam at 85 to 100 ° C for 4 to 6 hours to be steamed, then dried at 50 to 80 ° C for 12 to 24 hours and powdered to obtain fermented powdered medicinal material (A1) (S1) < / RTI > (B), which was prepared by immersing in alcohol for 1 month, and then mixing dried, interdigitated antler, washed, dried and sectioned sea cucumber, and almond at a weight ratio of 2: 1: 2, was added to EM fermentation broth and fermented at room temperature for 72 hours (S2) of steamed and steamed at 85 to 100 ° C for 1 to 3 hours and then dried at 50 to 80 ° C for 6 to 12 hours and pulverized to prepare a fermented powdered medicinal material (B1) ; (S3) mixing the fermented powdered medicinal preparation (A1) prepared in the step (S1) and the fermented powdered medicinal preparation (B1) prepared in the step (S2) at a weight ratio of 4: 1.

As a preferred embodiment of the present invention, the EM fermentation broth is prepared by mixing 30% by weight of lactic acid bacteria, 30% by weight of yeast bacteria, 30% by weight of lead curative bacteria, 5% by weight of acetic acid bacteria and 5% by weight of photosynthetic bacteria, And then cultured for 1 month at 20 to 30 ° C without feeding the medium. Then, 50 g of ground ginseng and 10 g of sugar ground per liter of the EM stock solution were added to the EM stock solution, To prepare an EM activity solution, and mixing the EM activity solution and purified water at a volume ratio of 1:10.

According to the present invention, by separating and fermenting a water-soluble medicinal material and a lipid-soluble medicinal material, it is possible to prevent the growth of anaerobic microorganisms that may occur as the fermentation speed varies when all the medicines are fermented at the same time, It is possible to improve the absorption rate of the human body of the herbal composition according to the present invention which is effective for the treatment of thyroid disease and to improve the metabolic rate of the human body and to improve the digestive dysfunction which may occur even when taking the new lipid or antiloid.

In addition, by powdering the herbal composition, it is convenient to take and store, and can be easily mixed with other herbal ingredients or compositions.

In addition, fermentation of the medicinal ingredient through the EM fermentation broth using ginseng enhances the activity of beneficial microorganism (EM), resulting in fermentation well, and the ginseng radish potency of ginseng can be expressed in the herbal composition prepared by the present invention.

The present invention relates to a method for treating or preventing thyroid diseases such as hypothyroidism and the like (for example, chronic fatigue, edema, poor circulation, poor appetite, hemorrhoids, dry skin, hair loss, The menstrual irregularities, etc.) are fermented with a specific EM fermentation broth, and the water-soluble medicinal materials and the oil-soluble medicines are separately fermented and pulverized, respectively. To improve.

Hereinafter, the pharmaceutical ingredients used in the present invention will be described in detail, and then a method for producing the composition will be described.

In the present invention, water-soluble medicinal materials are used as medicaments such as Sukjunggang, Angelica gigas, Baekjang medicine, Lycopersicon esculentum, Lycopersicum, Mulberry, Broodstock,

The above-mentioned Rehmanniae Radix Preparata is dried by steaming the roots of medicinal plants attached to the ginseng root, and is used as a medicinal herb. The raw root is called raw persimmon, and the dried persimmon is called persimmon. It is said to be made by repeating 9 times of drying, and it is said to be the most effective. It has a bitter taste with a bitter taste, but it has a warm temperament, and it replenishes its blood and replenishes its essence (a substance that is fundamental to life and activity). It causes back and knee pain, sore symptoms, menstrual disorder, dizziness It has the efficacy to cure the head and darken the head. Sukjipang is the main medicinal material of Sangmangtang, and it is used for symptoms such as inner heat, sore throat, and thirst which are manifested by weakness of various chronic diseases.

Angelica is the root of Umbelliferae, Angelica acutiloba K.. Angelica has long been famous as a potion of rejuvenation. It is used for sedation therapy such as calm gauze, sedation medication, anemia, and menstrual irregularity. It has a bi - directional regulating action on the uterus, which can strengthen or relax the uterine muscle contraction. It is an important medicinal material for postpartum recovery, blood, blood, and other gynecological diseases. It also has an inhibitory action against Escherichia coli, Diput bacteria and the like.

Paeonia japonica (Paeonia japonica) is a perennial herb that is a herbaceous herbaceous perennial herbaceous plant. It has analgesic and soothing effects, relieves maternal eosinophilia, calms menstrual cramps, and has excellent restorative effects. In particular, it reinforces blood on the inner wall of the uterus and functions to soften the uterus, ligaments around the fallopian tube, and muscles.

Diacorea Rhizoma is a root of the root of Dioscorea japonica or Disocorea batatas belonging to the family Dioscoreaceae. It is mainly composed of mannan which is a viscous polysaccharide and protein, minerals and steroid saponin and phenanthrene derivative . It boosts immune recovery, lowers blood cholesterol, and increases digestion. It is also effective against the treatment of inflammation and coldness of women.

White roots are the roots of Atractylodes japonica Koidzumi or Atractylodes macrocephala Koidzumi (Compositae), which are removed as they are, and the function of the stomach is fragile, resulting in a feeling of malaise, It is diluted in the stool, good for diarrhea, stagnant in water, helps to excrete the fluid when the whole body is swollen and not digested. Pharmacological increase of mice weight gain and endurance, increase phagocytic ability, promotion of cell immune function was reported. In addition, intestinal (intestinal) inhibition and control of excitement, anti-ulcer and liver function protection, immune function hyperactivity, vasodilation, diuretic and hypoglycemic action, anti-cancer action has been reported.

The pulp belongs to the Paeoniaceae and mainly uses the root bark. The pulp contains paeonoside, paeonolide and paeonol, which break down during storage to produce sugars and paeonols. In particular, the root bark of the mulberry has the symptoms of menstrual irregularities caused by hemorrhoids, menstrual pain, bruises, hemorrhages, nosebleeds, spots appearing, symptoms of tingling due to fever, elevated blood pressure, eosinophilia, bruises, It is used at the beginning of appendicitis and removes chest tightness. There is a pharmacological action such as analgesia, sedation, fever, anticonvulsant, anti-inflammatory, anti-thrombotic, antiallergic, gastric secretion inhibition, uterine mucous membrane congestion and antimicrobial action (pp. 521;

Broccoli (肉桂) is a stem skin of Cinnamomum cassia Presl (camphora and Lauraceae), or it is a little removed from juniper. It contains 1 ~ 2% of volatile essential oil components and 75 ~ 90% of cinnamic aldehyde as main component. It also contains mucilage, tannin, etc., and phellandrene, , Eugenol, and methyleugenol. It has sedative, analgesic and antipyretic action because it inhibits the central nervous system. It stimulates the blood flow of the heart and coronary arteries, has anti-radioactivity, increases leukocyte count, and inhibits skin fungi.

The action of Gugija (枸杞 子) is as follows. 1) Gugija's polysaccharide increases the number of leukocytes and neutrophils (enhances and regulates immune function), 2) regulates the increase of leukocyte count and function (enhancing hematopoietic function), 3) (Antitumor activity), which inhibits DNA synthesis in tumor cells and inhibits cell division, thereby reducing cell proliferation. 4) It has antioxidant action, which increases the amount of hydroxyproline in mouse skin tissue. It is a kind of crystalline amino acid and a component of collagen.

Cyperus rotundus L. is a perennial plant of the genus Cyperus rotundus, which contains essential oils, alkaloids, cardiac glycosides, flavonoids, sugar, pectin, oil, resin and organic acids throughout the rootstock. Fluid excretion of rootstock has analgesic action and lowering of uterine tension, and it has a strong action and a diuretic effect and makes blood circulate well. It is widely used for menstruation, menstrual cramps, menstrual pain, and postpartum women's diseases due to menstrual and phthisic medicine. It is also used when there is no cold, headache, stomachache, or appetite in a prescription for a calming and calming medicine.

The crust (Aurantii Fructus Immaturus) is a medicinal product made from mature fruit of the evergreen small or ungulate tree (Poncirus trifaliata RAFIN.) And citrus tree (Citrus aurantium L.) belonging to the genus Udon. It contains essential oils and flavonoids, which contain Neohesperidin, Naringin, and Vitamin C. Because it shows a gigantic function while removing energy, it removes the intestine and shows digestive effect on the key.

Cuscuta japonica is a perennial parasitic herbaceous parasite which is parasitic on the bark of the gabbroside of the maracchicine plant. It contains vitamin A, β-carotene, γ-carotene, and 5-carotene. , 6-epoxy-α-carotene, teraxanthin, and rutin, which are effective for restorative, renal function and male and female reproductive functions.

(Uncaria macrophylla Wall, Rubiaceae), Uncaria rhynchophylla (Miq.) Jacks, Rubiaceae, etc.), Which is an evergreen vine plant of dead dogs, And its efficacy in the treatment of hypertension of the adult, dizziness, nausea, vomiting, diarrhea, nausea, vomiting, diarrhea, It treats the symptom which is stinging in front of the eyes, the woman 's intertwine (child 癎).

The main pharmacological components are rhynchophylline, isorhynchophylline, corynoxeine, isocorynoxeine, corynantheine, dihydrocorynantheine and hirsutine. It acts on the central nervous system vasomotor center by the action of rhynchophylline, And thus exhibits a strong blood pressure effect. In addition, Zugu lacquer has diastolic and cardiovascular functions. It has been shown to be sedative through animal experiments and has a relaxation effect on smooth muscle, suppressing spastic cough.

Ganoderma lucidum is also called as mushroom, mushroom, etc. It stabilizes the mind and body, and supplementes the blood of the ginseng to maintain youthfulness. Especially, it is a medicinal substance used as nervous breakdown, insomnia and anticancer drug. It is known that selenium protects DNA and prevents it from binding to carcinogens (anticancer, antioxidant).

In the present invention, antler, sea cucumber, and almond are used as lipid-soluble medicines.

Cervus nippon Temminck, C. elaphus Linne or C. canadensis Erxleben belonging to the deer and deer Cervidae were found to have a dense, The slightly ossified young horn is cut and then dried. Antler contains 16 kinds of amino acids, among which proline, lysine and serine are known to be the most abundant. Deer antler contains a large amount of amines, among which spermine, spermidine, and putrescine are abundant. In the middle and lower part of the antler, there is much ossification and the content of spermidine is decreased. In addition, collagen, estrone, and proteolipid are included.

Donguibogam has been told that antler antagonist strengthens the five oysters, replenishes the tinnitus, and helps strengthen weak immunity. As an ingredient of antler antler, 54% of organic matter is hormone and growth factor of protein (collagen, glycosaminoglycan), fatty acid (oleic acid, unsaturated fatty acid, omega 6 fatty acid, EPA, DHA etc.). 34% of the minerals are calcium, phosphorus, magnesium, iron, potassium, sodium, etc. and the moisture is 12%.

In addition, antler antagonism has hematopoietic action and blood circulation improvement effect, and especially antler contains antler diol. By taking these natural estradiol, you can improve hormone-related diseases in women while reducing the side effects of oral estrogens. In addition, it lowers blood cholesterol to prevent arteriosclerosis and prevent cardiovascular disease.

Sea cucumber is a generic term for sea cucumbers belonging to the sea cucumber river. It was named for its efficacy as ginseng. As food science, sea cucumbers are mostly water, 90.5% are mostly water, 3.2% protein, 0.2% fat and 3.5% inorganic. The minerals are high in calcium, high in protein quality, and contain calcium and phosphorus in an appropriate ratio. There are many chondroitin sulfate in cartilage part. The content of saponin, which is a functional ingredient of ginseng, is high and is called ginseng of the sea.

Almond (Prunus dulcis) is a nutritious nut, first of all, it contains a lot of unsaturated fatty acids, which helps to lower the triglyceride and serum cholesterol levels in our bodies and to eliminate the fat in the blood vessels, Heart disease, and vascular disease. Particularly, omega-3 fat, which is an unsaturated fatty acid, activates neuronal cells, which is good for the health of the elderly, growing children, and examinees. When they chew hard nuts, they stimulate the brain to increase the blood flow of the brain, .

In particular, almonds also contain a large amount of selenium. In addition, almonds contain a lot of vitamin E to prevent hair loss, anti-aging, skin beauty is effective. It strengthens and shines hair, prevents hair loss, protects cell membranes, helps blood flow and keeps skin healthy and elastic. And it has an antioxidant effect, which is also excellent for preventing aging.

The present invention is characterized in that the water-soluble medicinal material and the oil-soluble medicinal material are separately separated and separately fermented through a specific EM fermentation broth.

As an embodiment of the production method of the present invention, first, a step (method) (S1) of producing the water-soluble fermented powdery medicinal material A1 by fermenting the water-soluble medicinal materials is described.

The method for producing the water-soluble fermentation powdered medicinal material A1 using the water-soluble medicinal material is a method of preparing a water-soluble fermented powdery medicinal material A1 by mixing the water-soluble fermented powdered medicinal materials A1, (A) [or mixed medicament (A)] by mixing in a weight ratio of 1: 1: 1: 1: 1: 1: 2: 2: 2: 2: 2:

Next, the medicinal substance (A) is put into EM fermentation broth and fermented at room temperature for 48 hours. In the present invention, the water-soluble medicinal material and the oil-soluble medicament are fermented using an EM fermentation broth produced by a specific production method.

In the present invention, the EM fermentation broth is prepared by mixing 30% by weight of lactic acid bacteria, 30% by weight yeast, 30% by weight lead acetate, 5% by weight of acetic acid bacteria and 5% by weight of photosynthetic bacteria, And cultured for 1 month at 20 to 30 ° C without feeding the medium to prepare an EM stock solution. Then, 50 g of ground ginseng and 10 g of sugar ground per liter of the EM stock solution were added to the EM stock solution and fermented at 30 ° C for 7 days EM active liquid, and mixing the EM active liquid and purified water at a volume ratio of 1:10.

In the present invention, since the EM fermentation broth contains the ginseng component during the fermentation process, the beneficial microorganism (EM) activity is increased and fermentation is performed well, and the active ingredient of ginseng is also expressed in the herbal composition.

The mixed medicinal substance (A) is immersed in the EM fermentation broth and fermented, and then the fermented medicinal substance (A) is extracted and steamed for 4 to 6 hours with steam at 85 to 100 ° C. The steaming is carried out through a known steaming machine (or steamer) capable of steaming the medicinal material (A) under the above-mentioned method or condition.

When the steaming is completed, the mixture is dried in a known dryer at 50 to 80 ° C for 12 to 24 hours, and then pulverized using a known pulverizer or the like to complete the preparation of the fermented powdery pharmaceutical material (A1).

Meanwhile, as another embodiment of the manufacturing method of the present invention, a step (method) (S2) of producing the fat-soluble fermented powdery medicinal material B1 by fermenting the above-mentioned lipid soluble medicines will be described.

First, deer antler is immersed in alcohol for one month to remove blood and foreign matter, dried, and then cut (or cut) into 1 to 3 cm. Then, wash the sea cucumber thoroughly, dry it, and cut into 1 ~ 3cm.

The antler and sea cucumber prepared by the above method are mixed with almonds, and the antler, sea cucumber, and almonds are mixed at a weight ratio of 2: 1: 2 to prepare the medicinal material (B) or the mixed medicinal material (B).

Subsequently, the medicinal material (B) is put into the EM fermentation broth and fermented at room temperature for 72 hours. In the present invention, the room temperature may be 20 ± 5 ° C.

Likewise, the mixed medicinal material (B) is immersed in the EM fermentation broth and fermented. Then, the fermented medicinal material is steamed and steamed at 85 to 100 ° C for 1 to 3 hours. At this time, too, it can be carried out through a known steam boiler (or steamer) as described above.

After completion of the boiling of the medicinal material (B), the mixture is dried at a temperature of 50 to 80 ° C for 6 to 12 hours through a known dryer, and then pulverized using a known pulverizer or the like to complete the preparation of the fermented powdery medicinal material (B1) .

In the present invention, as described above, the water-soluble medicinal materials and the lipid-soluble medicines are fermented by different methods, respectively, when the water-soluble medicinal materials and the oil-soluble medicinal materials are mixed at the same time and fermented at the same time, (For example, anaerobic bacteria), and to maximize the absorption rate of the active ingredient by sufficiently fermenting the water-soluble medicinal material and the oil-soluble medicinal material according to the properties of the medicinal material.

As a preferred embodiment of the production method according to the present invention, the fermented powdered medicinal preparation A1 prepared in the step (S1) and the fermented powdered medicinal preparation (B1) prepared in the step (S2) are mixed in a weight ratio of 4: 1 (S3).

Thus, the fermented powdered medicinal material (A1) and the fermented powdered medicinal material (B1) are mixed at a weight ratio of 4: 1 as described above by the production method according to the present invention to prepare the fermented powdered medicinal material (C1) As a result, it is possible to obtain the fermented powdery medicinal material (C1) having a high human absorption rate of the active ingredient.

Further, according to the manufacturing method of the present invention, since the herbal composition (the above-mentioned fermented powder medicinal preparation (C1)) is prepared in powder form, it is convenient to store, conveniently drink or drink by mixing with other medicinal materials, The absorption rate is high.

Hereinafter, a preferred embodiment of the present invention will be described, and the efficacy of the herbal composition prepared according to the embodiment will be confirmed through experimental examples.

Example

1) First, 30% by weight of lactic acid bacteria, 30% by weight of yeast strains, 30% by weight of lead curdles, 5% by weight of acetic acid bacteria and 5% by weight of photosynthetic bacteria were mixed and cultured at 45 DEG C for 7 days in a medium, And the mixture was incubated at 20 to 30 ° C for 1 month to prepare an EM stock solution. 50 g of ground ginseng and 10 g of ground powder per liter of the EM stock solution were added to the EM stock solution and fermented at 30 ° C for 7 days to prepare an EM activity solution, The EM fermentation broth was prepared by mixing the EM activated solution and purified water at a volume ratio of 1:10.

2) Next, the medicinal materials (30 g), which is a mixture of 30 g of Sukjipjang, 30 g of Angelica gigas, 30 g of Baekjang 30 g, 30 g of Baekje, 30 g of pulp, 30 g of broiler, 60 g of Gugija, 60 g of perilla, 60 g of periwinkle, A) was added to the EM fermentation broth and fermented at room temperature for 48 hours. All of the fermented milk was steamed at 85 to 100 ° C for 5 hours, steamed for 12 hours, dried at 65 ° C and pulverized into powders And powdered through a pulverizer to prepare a fermented powdery medicinal material (A1).

3) The medicinal material (B), which was immersed in alcohol for one month, and then dried, 200 g of antler grains cut into 1 to 3 cm, washed and dried, 100 g of sea cucumber cut into 1 to 3 cm and 200 g of almond, And then fermented at room temperature for 72 hours. All of the fermented milk was steamed and steamed at 85 to 100 ° C for 2 hours, then dried at 65 ° C for 9 hours, and then pulverized through a known pulverizer A fermented powder medicine (B1) is prepared.

4) 400 g of the prepared fermented powdered medicinal material (A1) and 100 g of the prepared fermented powdered medicinal material (B1) are mixed while stirring well to prepare a fermented powdered medicinal material (C1).

Experimental Example

The composition of the fermented powdered medicinal product (C1) according to the present invention was administered to three volunteers having hypothyroidism or thyroiditis in a powder form together with water three times a day, 200 g each time. The information of each applicant and the results before and after taking the dose were as follows.

(1) Applicant 1: Female, 47 years old

  1) Symptoms before taking

  - Fatigue and severe anemia due to hypothyroidism

  - T4 (Thyroxine) 4.5

  - TSH (Thyroid-stimulating hormone) 16.58

  2) After taking

  - Free T4 1.15 (normal), TSH 1.65 (normal) after 30 days of recovery

(2) Applicant 2: Female, 53 years old

  1) Symptoms before taking

  - hypothyroidism, edema and chronic fatigue symptoms

  - Free T4 0.68, TSH 10.5

  2) After taking

  - Free T4 1.40 (normal) and TSH 0.932 (normal) after 30 days of recovery

(3) Applicant 3: W, age 62

  1) Symptoms before taking

  - Symptoms of thyroiditis

  2) After taking

  - After 3 months, tri-iodothyronine 1.23 (normal), Free T4 1.32 (normal)

   TSH 0.954 (normal)

As shown in the above results, the composition prepared by the method according to the present invention was diagnosed through a thyroid function test (T3, T4, Free T4, TSH) after hypothyroidism or thyroiditis ingestion for a certain period of time, And the function was restored to normal.

In other words, it was confirmed that the levels of thyroid hormone T3 and T4 were maintained within the normal range (T3: 0.58 ~ 1.59, T4: 0.70 ~ 1.48) and the TSH level was within the normal range of 0.35 ~ 4.49. In addition, the autoimmune antibody levels (anti-TPO and anti-TG) of hypothyroidism also decreased to the stable state.

The method for preparing a herbal composition for treating thyroid disease including deer which is produced by the manufacturing method according to the present invention in a form capable of taking or drinking can be any pharmaceutical acceptable formulation without any particular limitation. For example, formulations of powders, electrolytic solutions, and pills.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, It will be apparent to those skilled in the art that various modifications may be made without departing from the scope of the present invention.

Claims (1)

A method for preparing a herbal composition for treating thyroid disease,
1: 1: 1: 1: 1: 1: 2: 2: 2: 2: 1: 1: 1: 2: 2: 2: (A) mixed in a weight ratio of 2: 2 is put into an EM fermentation broth and fermented at room temperature for 48 hours. The fermented product is then steamed with steam at 85 to 100 ° C for 4 to 6 hours and then steamed for 12 to 24 hours, Drying at 80 캜 and pulverizing to produce a fermented powdered medicinal material A1;
(B), which was prepared by immersing in alcohol for 1 month, and then mixing dried, interdigitated antler, washed, dried and sectioned sea cucumber, and almond at a weight ratio of 2: 1: 2, was added to EM fermentation broth and fermented at room temperature for 72 hours (S2) of steamed and steamed at 85 to 100 ° C for 1 to 3 hours and then dried at 50 to 80 ° C for 6 to 12 hours and pulverized to prepare a fermented powdered medicinal material (B1) ;
(S3) mixing the fermented powdered medicinal preparation (A1) prepared in the step (S1) and the fermented powdered medicinal preparation (B1) prepared in the step (S2) at a weight ratio of 4: 1,
In the EM fermentation broth,
The culture medium was prepared by mixing 30% by weight of lactic acid bacteria, 30% by weight of yeast strains, 30% by weight lead acetate, 5% by weight of acetic acid bacteria and 5% by weight of photosynthetic bacteria at 30-50 ° C for 7 days, After culturing for 1 month at 30 DEG C to prepare an EM stock solution, 50 g of ground ginseng and 10 g of ground powder per liter of the EM stock solution were added to the EM stock solution and fermented at 30 DEG C for 7 days to prepare an EM activity solution. Wherein the active ingredient and the purified water are mixed at a volume ratio of 1: 10 to prepare a herbal composition for treating thyroid disease.