CN111671875A - Chinese herbal medicine extract for preventing and treating porcine epidemic diarrhea and preparation method thereof - Google Patents

Chinese herbal medicine extract for preventing and treating porcine epidemic diarrhea and preparation method thereof Download PDF

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Publication number
CN111671875A
CN111671875A CN202010745868.XA CN202010745868A CN111671875A CN 111671875 A CN111671875 A CN 111671875A CN 202010745868 A CN202010745868 A CN 202010745868A CN 111671875 A CN111671875 A CN 111671875A
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parts
root
seed
raw materials
radix
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苏同兴
陈智
康子凡
牛菽媛
蒋宛辰
苏华山
康胜利
牛克平
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
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Abstract

The invention relates to the technical field of livestock and poultry breeding, and particularly discloses a Chinese herbal medicine extract for preventing and treating porcine epidemic diarrhea and a preparation method thereof. The Chinese herbal medicine extract is prepared by fermenting, extracting and preparing trichosanthes seed, plantain seed, figwort root, cimicifuga foetida, oriental wormwood, dandelion, cochinchnese asparagus root, dwarf lilyturf tuber, bamboo shavings, coptis root, epimedium herb, pyrrosia lingua, prepared rehmannia root, red paeony root, white paeony root, cyrtomium rhizome, hemerocallis root, nutgrass galingale rhizome, schizonepeta spike, mongolian snakegourd root, garden burnet root, myrrh, Chinese honeylocust fruit, parasitic loranthus, areca nut, common clubmoss herb, bunge cherry seed, white poria, red poria, medicated leaven, benzoin, loquat leaf, dark plum fruit, cordyceps sinensis, sea cucumber, liquorice. The feed additive has the advantages of easily available raw materials and simple preparation process, effectively improves the intestinal environment of pigs, improves the activity of beneficial flora, further improves the immunity of sows, effectively protects newborn piglets, and cures porcine epidemic diarrhea.

Description

Chinese herbal medicine extract for preventing and treating porcine epidemic diarrhea and preparation method thereof
(I) technical field
The invention relates to the technical field of livestock and poultry breeding, in particular to a Chinese herbal medicine extract for preventing and treating porcine epidemic diarrhea and a preparation method thereof.
(II) background of the invention
Influenced by factors such as 'pig cycle' descending, impact of African swine fever epidemic situation, improper feeding and limited breeding in some places and the like, the yield of the pigs living in the whole country in 2019 is reduced more, and the price of the pigs greatly rises. According to the data of the national statistical bureau, the number of stored pigs in 2019 is 31041 ten thousand, which is reduced by 27.5% compared with the number of stored pigs in the last year, and the number of discharged pigs in all years is 54419 ten thousand, which is reduced by 21.6% compared with the number of stored pigs in the last year.
The pathogenic Porcine Epidemic Diarrhea Virus (PEDV) belongs to the genus of coronavirus of the family Coronaviridae, and belongs to the same genus as the currently epidemic new coronavirus. PEDV can infect pig bodies through the digestive tract, respiratory tract and muscle inoculation ways, the digestive tract transmission (through feces-mouth) is the main but not the only transmission way of PED (porcine epidemic diarrhea), the PEDV can also be replicated in the respiratory tract, and the PEDV can infect susceptible swinery after being discharged outside through respiratory tract secretion; a common clinical transmission route is fecal transmission, and PEDV can cause diseases of susceptible pigs through mechanical carrying of people, vehicles, mice and the like.
PEDV can infect pigs of any age, but infected pigs of different ages have different severity of disease. In fact, the morbidity of sows infected with PEDV is usually 15%, the morbidity of piglets reaches 80% -90%, the influence on suckling piglets is the most serious, the mortality of piglets suckled with PED reaches 80%, and the morbidity and mortality of newborn piglets reach 100%.
Because of the death of a large number of piglets, the PEDV infection causes the slaughtering rate of the live pigs to be reduced, the pork supply is insufficient and the price is unstable, the reduction of the pork yield can be between 3 and 11 percent, and a series of food safety problems are caused.
Disclosure of the invention
In order to make up for the defects of the prior art, the invention provides the Chinese herbal medicine extract for preventing and treating the porcine epidemic diarrhea, which has the advantages of simple preparation, obvious curative effect, readily available raw materials and low cost, and the preparation method thereof.
The invention is realized by the following technical scheme:
a Chinese herbal medicine extract for preventing and treating porcine epidemic diarrhea is prepared by fermenting, extracting and pulverizing the following raw materials in parts by weight:
2-3 parts of semen trichosanthis, 2-3 parts of semen plantaginis, 1-2 parts of radix scrophulariae, 1-2 parts of rhizoma cimicifugae, 1-3 parts of oriental wormwood, 1-3 parts of dandelion, 0.5 part of radix asparagi, 0.5 part of radix ophiopogonis, 1-2 parts of bamboo shavings, 1-2 parts of coptis chinensis, 1 part of herba epimedii, 1 part of pyrrosia lingua, 1-3 parts of prepared rehmannia root, 1-2 parts of red peony root, 1-2 parts of white peony root, 2-4 parts of cyrtomium rhizome, 0.5 part of radix hemerocallis, 0.5 part of rhizoma cyperi, 1-3 parts of schizonepeta spike, 1 part of radix trichosanthis, 1 part of garden burnet, 1-3 parts of kelp, 1-3 parts of lophatherum gracile, 1 part of cortex moutan bark, 1-2 parts of dichroa febrifuga, 1 part of bighead atractylodes rhizome, 1-3 parts of fructus evodiae, 0.5 part of amomi, 0.5 part of amomum kravan, 1 part of pubescent angelica root, 1 part of officinal magnolia bark, 1-3 parts of Chinese eaglewood, 1 part of dried orange peel, 1-3 parts of costustoot, 1-3 parts of halite, 1 part of actinolite, 1-3 parts of argy wormwood leaf, 1-3 parts of nutmeg, 1-3 parts of common curculigo rhizome, 1 part of areca seed, 1 part of edestan, 1-3 parts of astragalus root, 1 part of green tangerine peel, 2-4 parts of scouring rush, 1-3 parts of cassia seed, 1-3 parts of dendrobium stem, 1 part of cattail pollen, 1 part of myrrh, 1-3 parts of Chinese honeylocust fruit, 1-3 parts of parasitic loranthus, 1-3 parts of small grass, 1 part of bunge cherry seed, 1-3 parts of white poria, 1-3 parts of red poria, 2-4 parts of medicated leaven, 1-3 parts of benzoin, 2-4 parts of loquat leaf, 2-4 parts of dark plum fruit, 1 part of Chinese caterpillar fungus, 1 part of, 1 part of selenium yeast.
The preferable weight ratio of the raw materials is as follows:
2.5 parts of semen trichosanthis, 2.5 parts of semen plantaginis, 1.5 parts of radix scrophulariae, 1.5 parts of rhizoma cimicifugae, 2 parts of oriental wormwood, 2 parts of dandelion, 0.5 part of radix asparagi, 0.5 part of radix ophiopogonis, 1.5 parts of bamboo shavings, 1.5 parts of coptis chinensis, 1 part of herba epimedii, 1 part of pyrrosia lingua, 2 parts of prepared rehmannia root, 1.5 parts of red paeony root, 1.5 parts of white peony root, 3 parts of cyrtomium rhizome, 0.5 part of hemerocallis root, 0.5 part of rhizoma cyperi, 2 parts of schizonepeta spike, 1 part of trichosanthes root, 1 part of garden burnet root, 2 parts of kelp, 2 parts of lophatherum gracile, 1 part of cortex moutan bark, 1.5 parts of antifebrile dichroa, 1 part of white atractylodes rhizome, 2 parts of fructus evodiae, 0.5 parts of amomum melegueta, 0.5 parts of cardamomum, 1 part of resina draconis, 1 part of sandalwood, 2 parts of purple perilla, 2 parts of hyacinth bean, 1 part of semen coicis, 1 part of semen artemisiae, 1 part of ephedrae, 1, 3 parts of scouring rush, 2 parts of cassia seed, 2 parts of dendrobium, 1 part of cattail pollen, 1 part of myrrh, 2 parts of Chinese honeylocust fruit, 2 parts of parasitic loranthus, 2 parts of small grass, 1 part of bunge cherry seed, 2 parts of white poria, 2 parts of red poria, 3 parts of medicated leaven, 2 parts of benzoin, 3 parts of loquat leaf, 3 parts of dark plum fruit, 1 part of cordyceps sinensis, 1 part of sea cucumber, 3 parts of liquorice, 1 part of pollen and 1 part of selenium yeast.
According to the principle of strengthening body resistance and eliminating pathogenic factors of traditional Chinese medicine, the extracts obtained by scientifically mixing the Chinese herbal medicines with different cold-heat-warm properties according to the principle of assistant and guide of monarch drugs effectively inhibit the reproduction of virus bacteria, improve the immune function of a pig digestive system (stomach channel, liver channel, gallbladder channel, large intestine channel and small intestine channel), simultaneously strengthen the body resistance of shoulder viscera channel, lung channel and bladder channel, and restore the balance of beneficial flora in intestinal tracts.
In the invention, the medicinal properties of the raw materials are as follows:
trichosanthes seed: clearing lung-heat, eliminating phlegm, smoothing intestine and relaxing bowels; plantain seed: clearing away heat, promoting urination, improving eyesight, and eliminating phlegm; figwort root: cooling blood, nourishing yin to reduce pathogenic fire, and removing toxic substance; cimicifugae foetidae: relieving exterior syndrome, promoting eruption, clearing away heat and toxic materials, and invigorating yang; herba Artemisiae Scopariae: clearing away heat, promoting diuresis, and eliminating jaundice; dandelion: clearing away heat and toxic materials, eliminating carbuncle, and dispersing pathogenic accumulation; radix asparagi: nourishing yin to moisten dryness, clearing lung-heat to reduce pathogenic fire; and (3) dwarf lilyturf root: nourishing yin and moistening lung, benefiting stomach and promoting fluid production, clearing heart fire and relieving restlessness; bamboo shavings: clearing heat, eliminating phlegm, relieving restlessness, relieving vomiting, preventing miscarriage and cooling blood; coptis chinensis: clearing heat and purging fire, eliminating dampness and removing toxicity; herba epimedii: invigorating kidney, supporting yang, strengthening tendons and bones, dispelling pathogenic wind, and removing dampness; and (3) pyrrosia lingua: promoting diuresis for treating stranguria, clearing lung-heat, eliminating phlegm, cooling blood and stopping bleeding; prepared rehmannia root: clearing heat and cooling blood, promoting fluid production and moistening dryness; red peony root: clear heat and cool blood, activate blood and dispel stasis.
White peony root: nourishing blood, regulating nutrient, relieving spasm and pain, astringing yin, and calming liver; rhizoma Osmundae: clearing away heat and toxic materials, cooling blood and stopping bleeding, and killing parasites; root of Hemerocallis: clearing heat, promoting diuresis, cooling blood, stopping bleeding, removing toxic substance, and relieving swelling; rhizoma cyperi: regulating qi-flowing, resolving stagnation, regulating menstruation, and preventing miscarriage; schizonepeta spike: dispelling pathogenic wind, relieving exterior syndrome, promoting eruption, and stopping bleeding; trichosanthes root: clearing heat, promoting fluid production, moistening lung, eliminating phlegm, relieving swelling, and expelling pus; garden burnet root: cool blood to stop bleeding, clear heat and remove toxicity; kelp: softening hard masses, resolving phlegm, inducing diuresis and relieving edema; herba lophatheri: clearing heat, relieving restlessness and promoting urination; moutan bark: clearing heat and cooling blood, promoting blood circulation and removing blood stasis; dichroa febrifuga: malaria interception and sputum robbery; white atractylodes rhizome: invigorate spleen, replenish qi, dry dampness, induce diuresis, stop sweating, prevent abortion.
Evodia fruit: dispel cold, warm the middle warmer, relieve depression, dry dampness; and (3) shrinkage honey: promoting qi circulation, relieving epigastric distention, invigorating stomach, resolving food stagnation, and preventing miscarriage; round cardamom fruit: resolve dampness, promote qi circulation, warm middle energizer, arrest vomiting, stimulate appetite and promote digestion; and (3) drying paint: removing blood stasis, removing food retention, and killing parasites; sandalwood: promoting qi circulation, removing blood stasis, and relieving pain; perilla seed: descending qi, eliminating phlegm, relieving asthma, and moistening intestines; haricot: to invigorate the spleen, resolve dampness and relieve summer-heat.
The cuttlefish bone is the inner shell of cuttlefish or cuttlefish of cuttlefish family; the Chinese medicine is used as hemostatic medicine and has the functions of relieving hyperacidity and pain, stopping bleeding, setting bone, repairing bone defect, resisting radiation, resisting tumor, resisting ulcer, etc.
Radix angelicae pubescentis: dispelling pathogenic wind and dampness, dispelling cold and relieving pain; magnolia officinalis: move qi and remove food stagnation, dry dampness, check adverse flow of qi and relieve dyspnea; agilawood: warming the middle energizer to lower adverse flow of qi, warming the kidney and receiving qi; dried orange peel: regulating qi-flowing, lowering adverse qi, relieving vomit, eliminating dampness, and eliminating phlegm; costustoot: move qi and alleviate pain, regulate middle energizer and remove food stagnation.
The green salt is salt directly extracted from salt lake and salt produced by sun-drying salt lake brine as raw material in salt pan.
Actinolite: warming kidney and strengthening yang; folium artemisiae argyi: warming channels to stop bleeding, preventing miscarriage, expelling cold and dampness, and regulating qi and blood; nutmeg: warming the middle energizer and astringing the intestines, promoting qi circulation and promoting digestion; rhizoma curculiginis: warming kidney, strengthening yang, dispelling cold and eliminating dampness; betel nut: expelling parasites and removing food retention, descending qi and promoting water circulation, and preventing malaria; and (3) hemp seed: moistening dryness, smoothing intestine, promoting diuresis, and promoting blood circulation; astragalus root: replenishing qi to invigorate yang, consolidating superficial resistance to arrest sweating, inducing diuresis to alleviate edema, expelling toxin and promoting granulation; green tangerine peel: soothing the liver, breaking qi, removing food retention and resolving stagnation; b, horsetail: dispelling wind and heat, improving eyesight, removing nebula, and stopping bleeding; cassia seed: clearing liver-fire, improving eyesight, promoting diuresis and relaxing bowels; dendrobe: promoting the production of body fluid, benefiting stomach, nourishing yin and clearing heat; cattail pollen: hemostasis, removing blood stasis, diuresis; nutgall: astringe intestines, secure essence, astringe lung, stop bleeding; spina gleditsiae: detumescence, pus discharge, wind dispelling, and parasite killing; parasitic loranthus: tonify liver and kidney, strengthen tendons and bones, dispel wind-damp, prevent abortion; grass: dispel phlegm, soothe the nerves and cure carbuncle; the Chinese dwarf cherry seeds: loosening bowel to relieve constipation, descending qi and promoting diuresis; white poria: promoting diuresis, eliminating dampness, invigorating spleen, regulating stomach function, calming heart, and tranquilizing mind; red poria: move water and remove dampness; medicated leaven: promoting digestion, eliminating food stagnation, invigorating spleen and regulating stomach function; benzoin: inducing resuscitation, removing filth, promoting qi circulation, and relieving pain; loquat leaf: clearing away lung-heat, regulating stomach function, descending qi, and quenching thirst; dark plum: astringe lung to stop cough, astringe intestine to stop diarrhea, stop bleeding, promote fluid production, relieve ascaris; and (3) cordyceps sinensis: tonifying lung, consolidating superficial resistance, invigorating kidney, and replenishing vital essence; sea cucumber: tonify kidney, replenish essence, nourish blood, moisten dryness and stop bleeding; licorice root: harmonize the middle energizer and relieve urgency, moisten lung, remove toxicity, and harmonize the recipe.
The pollen is rich in amino acids, vitamin A, vitamin C, vitamin E, active substances, trace elements selenium, phospholipid, nucleic acid, etc. Can remove various pigment spots, and has the effects of regulating nervous system, promoting sleep, improving body constitution, improving gastrointestinal function, promoting digestion, stimulating appetite, and preventing and treating habitual constipation.
Selenium yeast is an organic selenium preparation, has the advantages of high bioavailability, low toxicity, definite curative effect and the like, and has pharmacological effects of protecting the integrity of cell membranes, removing free radicals, accelerating the decomposition of lipid peroxides, resisting oxidation, enhancing the immune function of organisms, enhancing the cardiac muscle function and the like.
The preparation method of the Chinese herbal medicine extract for preventing and treating porcine epidemic diarrhea comprises the following steps:
(1) selecting the raw materials preferentially;
(2) mixing and crushing the raw materials, and placing the mixture in a fermentation tank;
(3) adding water into a fermentation tank, stirring uniformly, and fermenting and aging at 37-43 ℃ for 20-22 days;
(4) adding water into the fermentation tank, stirring, adjusting the viscosity of the fermentation material to 1.5-2.0 Pa.S, cooling, standing, filtering, and washing the filter residue with water;
(5) and mixing the filtrate and the washing liquid, grinding, and spraying to prepare powder to obtain the product.
The invention adopts the extraction processes of medium-temperature fermentation, low-temperature extraction and medium-temperature milling, and extracts the effective components in the raw materials to ensure that the effective components are combined and act on the positions of alimentary tracts, respiratory tracts and the like of pigs, so that beneficial flora advocated by the pigs can be regulated, harmful bacteria can be killed, and the intestinal health can be recovered.
Preferably, in the step (2), the raw materials are mixed and crushed and then screened by a 30-35-mesh sieve, wherein the selenium yeast is dissolved by deionized water and then added with water.
Preferably, in the step (3), deionized water is added into the fermentation tank and stirred, and the addition amount of the deionized water is 2.5-2.8 times of the total weight of the raw materials.
Preferably, in the step (4), deionized water is added into the fermentation tank, stirred, cooled to 12-18 ℃, kept stand for 36 hours, filtered by a 80-100 sieve, and then the filter residue is washed by deionized water for 2-3 times.
Preferably, in the step (5), the paste fluid with the fineness of 150-.
Porcine epidemic diarrhea is a common disease in pig farms, where pathogens coexist with pigs for a long time. The sow belongs to a non-pathogenic state with toxin during pregnancy, the immunity of the sow is reduced before and after parturition, the porcine epidemic diarrhea virus is accelerated to proliferate, and the content of the porcine epidemic diarrhea virus in blood is improved. After delivery, the virus is infected with milk sucked by piglets. The newborn piglets are weak in constitution, the toxic milk is the only food source, and the diarrhea cannot be effectively treated after the occurrence of the diarrhea, so that the high mortality rate is caused.
The traditional Chinese medicine extracts are added with pollen, selenium yeast and the like during the extraction process of effective medicinal components, so that active beneficial flora exists in the final traditional Chinese medicine extract, the activity of the flora in the pig intestinal tract is spontaneously adjusted, the activity of the beneficial flora is improved, the intestinal environment is adjusted to prevent the harmful flora from living, and the porcine epidemic diarrhea is quickly cured.
The feed additive has the advantages of easily available raw materials and simple preparation process, effectively improves the intestinal environment of pigs, improves the activity of beneficial flora, further improves the immunity of sows, enables the sows to generate effective antibodies, effectively protects newborn piglets, cures porcine epidemic diarrhea, and is suitable for wide popularization and application.
(IV) detailed description of the preferred embodiments
The technical solutions of the present invention are described in detail below with reference to specific examples to facilitate understanding of the present invention, but the present invention is not limited thereto.
Example 1: a Chinese herbal medicine extract for preventing and treating porcine epidemic diarrhea is prepared by mixing the following raw materials in parts by weight:
2kg of snakegourd fruit, 2kg of plantain seed, 1kg of figwort root, 1kg of cimicifuga foetida, 1kg of oriental wormwood, 1kg of dandelion, 0.5kg of radix asparagi, 0.5kg of radix ophiopogonis, 1kg of bamboo shavings, 1kg of coptis chinensis, 1kg of herba epimedii, 1kg of pyrrosia lingua, 1kg of prepared rehmannia root, 1kg of red peony root, 1kg of white peony root, 2kg of cyrtomium rhizome, 0.5kg of hemerocallis root, 0.5kg of rhizoma cyperi, 1kg of schizonepeta spike, 1kg of trichosanthes root, 1kg of sanguisorba officinalis, 1kg of kelp, 1kg of lophatherum gracile, 1kg of cortex moutan radicis, 1kg of antifebrile dichroa, 1kg of bighead atractylodes rhizome, 1kg of fructus evodiae, 0.5kg of sodium cyclamate, 0.5kg of amomum cardamomum, 1kg of dried lacquer, 1kg of sandalwood, 1kg of purple perilla, 1kg of hyacinth bean, 1kg of cuttle bone, 1kg of pubescent angelica root, 1kg of magnolia bark, 2kg of scouring rush, 1kg of cassia seed, 1kg of dendrobium, 1kg of cattail pollen, 1kg of myrrh, 1kg of Chinese honeylocust fruit, 1kg of parasitic loranthus, 1kg of areca seed, 1kg of small grass, 1kg of bunge cherry seed, 1kg of white poria, 1kg of red poria, 2kg of medicated leaven, 1kg of benzoin, 2kg of loquat leaf, 2kg of dark plum fruit, 1kg of cordyceps sinensis, 1kg of sea cucumber, 2kg of liquorice, 1kg of pollen and 1kg of selenium yeast.
The preparation method comprises the following steps:
(1) selecting the raw materials preferentially;
(2) mixing and crushing the raw materials, sieving the mixture by a 30-mesh sieve, and placing the mixture into a fermentation tank, wherein the selenium yeast is dissolved by deionized water and then is added with water;
(3) adding deionized water into the fermentation tank, stirring, wherein the addition amount of the deionized water is 2.5 times of the total weight of the raw materials, fermenting and aging at 37 ℃ for 22 days to obtain a material in a paste shape with a smell of dough;
(4) adding deionized water into a fermentation tank in a fermentation tank, stirring, adjusting the viscosity of the fermentation material to 1.5 Pa.S, cooling to 12 ℃, standing for 36h, filtering by a 80-mesh sieve, and washing the filter residue by deionized water for 2 times;
(5) mixing the filtrate and the washing solution, grinding twice by a colloid mill to obtain pasty fluid with fineness of 150 meshes, and then spraying at 65 ℃ to prepare powder to obtain the product.
Application test: 50g of the traditional Chinese medicine extract product is directly mixed in the feed of the farrowing sows and is added with three meals every day for feeding. The weight of the born sow is about 150kg, the common diseases of pig epidemic diarrhea such as vomit, diarrhea, dehydration and the like are shown, and the newborn piglet is petioned in spirit, anorexia and slight diarrhea.
And (3) test results: after the traditional Chinese medicine extract product is fed for one day, diarrhea symptoms are relieved, and vomiting symptoms still exist; after two days of feeding, the diarrhea and vomiting symptoms are further reduced; after feeding for three days, the vomiting symptom disappears, and the diarrhea symptom is further relieved; the disease heals after being fed for four days, and the symptom does not relapse after being further consolidated for two days; the newborn piglets gradually become active and love to eat and the diarrhea disappears along with the change of the sow state.
Example 2: a Chinese herbal medicine extract for preventing and treating porcine epidemic diarrhea is prepared by mixing the following raw materials in parts by weight:
3kg of snakegourd fruit, 3kg of plantain seed, 2kg of figwort root, 2kg of cimicifuga foetida, 3kg of oriental wormwood, 3kg of dandelion, 0.5kg of cochinchnese asparagus root, 0.5kg of ophiopogon root, 2kg of bamboo shavings, 2kg of coptis chinensis, 1kg of epimedium herb, 1kg of pyrrosia lingua, 3kg of prepared rehmannia root, 2kg of red peony root, 2kg of white peony root, 4kg of cyrtomium rhizome, 0.5kg of hemerocallis fulva root, 0.5kg of nutgrass galingale rhizome, 3kg of schizonepeta spike, 1kg of trichosanthes root, 1kg of sanguisorba officinalis, 3kg of kelp, 3kg of lophatherum gracile, 1kg of moutan bark, 2kg of dichroa febrifuga, 1kg of bighead atractylodes rhizome, 3kg of evodia, 0.5kg of amomum fruit, 0.5kg of amomum cardamomum, 1kg of dried lacquer, 1kg of sandalwood, 3kg of perilla, 3kg of purple perilla, 3kg of hyacinth bean, 1kg of cuttle bone, 1kg of pubescent angelica root, 4kg of scouring rush, 3kg of cassia seed, 3kg of dendrobium, 1kg of cattail pollen, 1kg of myrrh, 3kg of Chinese honeylocust fruit, 3kg of parasitic loranthus, 1kg of areca seed, 3kg of small grass, 1kg of bunge cherry seed, 3kg of white poria, 3kg of red poria, 4kg of medicated leaven, 3kg of benzoin, 4kg of loquat leaf, 4kg of dark plum fruit, 1kg of cordyceps sinensis, 1kg of sea cucumber, 4kg of liquorice, 1kg of pollen and 1kg of selenium yeast.
The preparation method comprises the following steps:
(1) selecting the raw materials preferentially;
(2) mixing and crushing the raw materials, sieving the mixture by a 35-mesh sieve, and placing the mixture into a fermentation tank, wherein the selenium yeast is dissolved by deionized water and then is added with water;
(3) adding deionized water into the fermentation tank, stirring, wherein the addition amount of the deionized water is 2.8 times of the total weight of the raw materials, fermenting and aging at 43 ℃ for 20 days to obtain a material in a paste shape with a smell of dough;
(4) adding deionized water into a fermentation tank in a fermentation tank, stirring, adjusting the viscosity of the fermentation material to 2.0 Pa.S, cooling to 18 ℃, standing for 36h, filtering through a 100-mesh sieve, and washing the filter residue with deionized water for 3 times;
(5) mixing the filtrate and the washing solution, grinding twice by a colloid mill to obtain pasty fluid with fineness of 200 meshes, and then spraying at 75 ℃ to prepare powder to obtain the product.
Application test: 50g of the traditional Chinese medicine extract product is directly dissolved in daily drinking water of the farrowing sows, added three times a day and fed along with the drinking water. The weight of the born sow is about 150kg, the common diseases of pig epidemic diarrhea such as vomit, diarrhea, dehydration and the like are shown, and the newborn piglet is petioned in spirit, anorexia and slight diarrhea.
And (3) test results: after the traditional Chinese medicine extract product is fed for one day, diarrhea symptoms are relieved, and vomiting symptoms still exist; after two days of feeding, the diarrhea and vomiting symptoms are further reduced; after feeding for three days, the vomiting symptom disappears, and the diarrhea symptom is further relieved; the disease heals after being fed for four days, and the symptom does not relapse after being further consolidated for two days; the newborn piglets gradually become active and love to eat and the diarrhea disappears along with the change of the sow state.
Example 3: a Chinese herbal medicine extract for preventing and treating porcine epidemic diarrhea is prepared by mixing the following raw materials in parts by weight:
2.5kg of snakegourd fruit, 2.5kg of plantain seed, 1.5kg of figwort root, 1.5kg of cimicifuga foetida, 2kg of oriental wormwood, 2kg of dandelion, 0.5kg of asparagus cochinchinensis, 0.5kg of ophiopogon root, 1.5kg of bamboo shavings, 1.5kg of coptis chinensis, 1kg of epimedium herb, 1kg of pyrrosia lingua, 2kg of prepared rehmannia root, 1.5kg of red paeony root, 1.5kg of white paeony root, 3kg of cyrtomium rhizome, 0.5kg of hemerocallis root, 0.5kg of nutgrass galingale rhizome, 2kg of schizonepeta spike, 1kg of trichosanthes root, 1kg of garden burnet root, 2kg of kelp, 2kg of lophatherum gracile, 1kg of tree bark of tree peony root, 1.5kg of atractylodes macrocephala, 2kg of evodia rutaecarpa fruit, 0.5kg of Chinese honey, 0.5kg of round cardamom, 1kg of dried lacquer, 1kg of sandalwood, 2kg of purple perilla, 2kg of hyacinth bean, 1kg of areca seed, 1kg of areca nut, 3kg of scouring rush, 2kg of cassia seed, 2kg of dendrobium, 1kg of cattail pollen, 1kg of myrrh, 2kg of Chinese honeylocust fruit, 2kg of parasitic loranthus, 1kg of areca seed, 2kg of small grass, 1kg of bunge cherry seed, 2kg of white poria, 2kg of red poria, 3kg of medicated leaven, 2kg of benzoin, 3kg of loquat leaf, 3kg of dark plum, 1kg of cordyceps sinensis, 1kg of sea cucumber, 3kg of liquorice, 1kg of pollen and 1kg of selenium yeast.
The preparation method comprises the following steps:
(1) selecting the raw materials preferentially;
(2) mixing and crushing the raw materials, sieving the mixture by a 32-mesh sieve, and placing the mixture into a fermentation tank, wherein the selenium yeast is dissolved by deionized water and then is added with water;
(3) adding deionized water into the fermentation tank, stirring, wherein the addition amount of the deionized water is 2.6 times of the total weight of the raw materials, fermenting and aging at 40 ℃ for 21 days to obtain a material in a paste shape with a smell of dough;
(4) adding deionized water into a fermentation tank in a fermentation tank, stirring, adjusting the viscosity of the fermentation material to be 1.8 Pa.S, cooling to 15 ℃, standing for 36h, filtering by a 90-mesh sieve, and washing filter residue by deionized water for 3 times;
(5) mixing the filtrate and the washing solution, grinding twice by a colloid mill to obtain pasty fluid with the fineness of 180 meshes, and then spraying at 70 ℃ to prepare powder to obtain the product.
Application test: 50g of the traditional Chinese medicine extract product is directly mixed into the feed of the multiparous sows and is added with three meals every day for feeding. The weight of the multiparous sow is about 200-250kg, which shows the common symptoms of porcine epidemic diarrhea, such as vomit, diarrhea, dehydration, and the like.
And (3) test results: after the traditional Chinese medicine extract product is fed for one day, diarrhea symptoms are relieved, and vomiting symptoms still exist; after two days of feeding, the diarrhea and vomiting symptoms are further reduced; after feeding for three days, the vomiting symptom disappears, and the diarrhea symptom is further relieved; the disease heals after being fed for four to five days, and the disease does not relapse after being further consolidated for two days.
The invention is enlarged and reduced, and the core problem is searched. The key of the treatment of the porcine epizootic diarrhea is to improve the immunity of the sow and reduce the virus carrying capacity of the sow, and the invention enables the sow to generate effective antibodies by improving the immunity of the sow and enables newborn piglets to be passively protected by sucking milk; the resistance of the newly born piglets is obviously improved after the piglets grow to 15 days, and the death rate is low even if the piglets are infected.
In the above embodiments, the best mode of the present invention has been described, and it is apparent that many changes can be made under the inventive concept of the present invention. It should be noted here that any changes made under the inventive concept of the present invention shall fall within the protective scope of the present invention.

Claims (7)

1. The Chinese herbal medicine extract for preventing and treating porcine epidemic diarrhea is characterized by being prepared from the following raw materials in parts by weight through fermentation, extraction and pulverization: 2-3 parts of semen trichosanthis, 2-3 parts of semen plantaginis, 1-2 parts of radix scrophulariae, 1-2 parts of rhizoma cimicifugae, 1-3 parts of oriental wormwood, 1-3 parts of dandelion, 0.5 part of radix asparagi, 0.5 part of radix ophiopogonis, 1-2 parts of bamboo shavings, 1-2 parts of coptis chinensis, 1 part of herba epimedii, 1 part of pyrrosia lingua, 1-3 parts of prepared rehmannia root, 1-2 parts of red peony root, 1-2 parts of white peony root, 2-4 parts of cyrtomium rhizome, 0.5 part of radix hemerocallis, 0.5 part of rhizoma cyperi, 1-3 parts of schizonepeta spike, 1 part of radix trichosanthis, 1 part of garden burnet, 1-3 parts of kelp, 1-3 parts of lophatherum gracile, 1 part of cortex moutan bark, 1-2 parts of dichroa febrifuga, 1 part of bighead atractylodes rhizome, 1-3 parts of fructus evodiae, 0.5 part of amomi, 0.5 part of amomum kravan, 1 part of pubescent angelica root, 1 part of officinal magnolia bark, 1-3 parts of Chinese eaglewood, 1 part of dried orange peel, 1-3 parts of costustoot, 1-3 parts of halite, 1 part of actinolite, 1-3 parts of argy wormwood leaf, 1-3 parts of nutmeg, 1-3 parts of common curculigo rhizome, 1 part of areca seed, 1 part of edestan, 1-3 parts of astragalus root, 1 part of green tangerine peel, 2-4 parts of scouring rush, 1-3 parts of cassia seed, 1-3 parts of dendrobium stem, 1 part of cattail pollen, 1 part of myrrh, 1-3 parts of Chinese honeylocust fruit, 1-3 parts of parasitic loranthus, 1 part of areca seed, 1-3 parts of small grass, 1 part of bunge cherry seed, 1-3 parts of white poria, 1-3 parts of red poria, 2-4 parts of medicated leaven, 1-3 parts of benzoin, 2-4 parts of loquat leaf, 2-4 parts of dark plum, 1 part of cordyceps sinensis, pollen 1 part and selenium yeast 1 part.
2. The Chinese herbal medicine extract for preventing and treating porcine epidemic diarrhea according to claim 1, wherein the extract is prepared by fermenting, extracting and pulverizing the following raw materials in parts by weight: 2.5 parts of semen trichosanthis, 2.5 parts of semen plantaginis, 1.5 parts of radix scrophulariae, 1.5 parts of rhizoma cimicifugae, 2 parts of oriental wormwood, 2 parts of dandelion, 0.5 part of radix asparagi, 0.5 part of radix ophiopogonis, 1.5 parts of bamboo shavings, 1.5 parts of coptis chinensis, 1 part of herba epimedii, 1 part of pyrrosia lingua, 2 parts of prepared rehmannia root, 1.5 parts of red paeony root, 1.5 parts of white peony root, 3 parts of cyrtomium rhizome, 0.5 part of hemerocallis root, 0.5 part of rhizoma cyperi, 2 parts of schizonepeta spike, 1 part of trichosanthes root, 1 part of garden burnet root, 2 parts of kelp, 2 parts of lophatherum gracile, 1 part of cortex moutan bark, 1.5 parts of antifebrile dichroa, 1 part of white atractylodes rhizome, 2 parts of fructus evodiae, 0.5 parts of amomum melegueta, 0.5 parts of cardamomum, 1 part of resina draconis, 1 part of sandalwood, 2 parts of purple perilla, 2 parts of hyacinth bean, 1 part of semen coicis, 1 part of semen artemisiae, 1 part of ephedrae, 1, 3 parts of scouring rush, 2 parts of cassia seed, 2 parts of dendrobium, 1 part of cattail pollen, 1 part of myrrh, 2 parts of Chinese honeylocust fruit, 2 parts of parasitic loranthus, 1 part of areca seed, 2 parts of small grass, 1 part of bunge cherry seed, 2 parts of white poria, 2 parts of red poria, 3 parts of medicated leaven, 2 parts of benzoin, 3 parts of loquat leaf, 3 parts of dark plum fruit, 1 part of cordyceps sinensis, 1 part of sea cucumber, 3 parts of liquorice, 1 part of pollen and 1 part of selenium yeast.
3. The method for preparing herbal extracts for preventing and treating porcine epizootic diarrhea according to claim 1, comprising the steps of: (1) selecting the raw materials preferentially; (2) mixing and crushing the raw materials, and placing the mixture in a fermentation tank; (3) adding water into a fermentation tank, stirring uniformly, and fermenting and aging at 37-43 ℃ for 20-22 days; (4) adding water into the fermentation tank, stirring, adjusting the viscosity of the fermentation material to 1.5-2.0 Pa.S, cooling, standing, filtering, and washing the filter residue with water; (5) and mixing the filtrate and the washing liquid, grinding, and spraying to prepare powder to obtain the product.
4. The production method according to claim 3, characterized in that: in the step (2), the raw materials are mixed and crushed and then screened by a 30-35-mesh sieve, wherein the selenium yeast is dissolved by deionized water and then added with water.
5. The production method according to claim 3, characterized in that: in the step (3), deionized water is added into the fermentation tank and stirred, and the addition amount of the deionized water is 2.5-2.8 times of the total weight of the raw materials.
6. The production method according to claim 3, characterized in that: and (4) adding deionized water into the fermentation tank, stirring, cooling to 12-18 ℃, standing for 36h, filtering by using a 80-100 sieve, and washing filter residues by using deionized water for 2-3 times.
7. The production method according to claim 3, characterized in that: in the step (5), the paste fluid with the fineness of 150-.
CN202010745868.XA 2020-07-29 2020-07-29 Chinese herbal medicine extract for preventing and treating porcine epidemic diarrhea and preparation method thereof Withdrawn CN111671875A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113023905A (en) * 2021-03-31 2021-06-25 北京局气网络技术有限公司 Plant fermentation extract for adjusting fresh water quality and preparation method thereof
CN113044995A (en) * 2021-03-31 2021-06-29 北京局气网络技术有限公司 Plant fermentation extract for freshwater aquaculture and preparation method thereof
CN113273649A (en) * 2021-06-30 2021-08-20 北京局气网络技术有限公司 Additive for improving pig intestinal flora structure and preparation method thereof
CN113292168A (en) * 2021-03-31 2021-08-24 北京局气网络技术有限公司 Plant fermentation extract for mariculture and preparation method thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113023905A (en) * 2021-03-31 2021-06-25 北京局气网络技术有限公司 Plant fermentation extract for adjusting fresh water quality and preparation method thereof
CN113044995A (en) * 2021-03-31 2021-06-29 北京局气网络技术有限公司 Plant fermentation extract for freshwater aquaculture and preparation method thereof
CN113292168A (en) * 2021-03-31 2021-08-24 北京局气网络技术有限公司 Plant fermentation extract for mariculture and preparation method thereof
CN113273649A (en) * 2021-06-30 2021-08-20 北京局气网络技术有限公司 Additive for improving pig intestinal flora structure and preparation method thereof

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