CN102861141B - Traditional Chinese veterinary medicine granules for clearing heat and stopping dysentery of livestock and preparation method thereof - Google Patents
Traditional Chinese veterinary medicine granules for clearing heat and stopping dysentery of livestock and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of medicine preparation, and particularly provides traditional Chinese veterinary medicine granules for clearing heat and stopping dysentery of livestock and a preparation method of the traditional Chinese veterinary medicine granules. The traditional Chinese veterinary medicine granules for clearing heat and stopping dysentery of livestock comprises the following components by mass part: 10 to 20 parts of radix sophorae flavescentis, 5 to 15 parts of mahonia fortunei, 5 to 15 parts of fennel, 5 to 15 parts of meadowrue root and rhizome, 5 to 15 parts of costustoot, 5 to 15 parts of shrubalthea flower, 5 to 15 parts of fructus terminaliae billericae, 5 to 10 parts of Chinese brake herb, 5 to 10 parts of angelica sinensis, and 5 to 10 parts of liquorice. The traditional Chinese medicine provided by the invention can be used for suppressing bacterium and removing bacterium, and also can be used for adjusting the physiological status of organism, so as to treat both symptoms and root causes; and the flavor and meridian tropism and the major function of traditional Chinese medicines are effectively utilized.
Description
Technical field
The invention belongs to field of medicine preparing technology, especially a kind of poultry herbal medicine granule of clearing away heat to cure dysentery and preparation method thereof.
Background technology
Livestock and poultry diarrhea is the common problem that current aquaculture runs into, diarrhoea is not an independent disease, but one of symptom of systemic disease or the comprehensive syndrome of gastroenteropathy, it is clinical that to common are microorganism sexual factor, toxic factor, parasitic factor, internal disease sexual factor, trophism factor, irritability factor, nerve factor, functional factor etc. multiple.Therapeutic modality commonly used is western medicine at present, and western medicine is mainly to use antibacterials, it can suppress or kill many Escherichia coli, but except Escherichia coli, also have a large amount of non-pathogenic floras in the body intestinal, they have important function to the homergy of body, blindly use antibacterials also can suppress or kill the non-pathogenic bacteria group in the body intestinal, and destroy its composition structure, and cause dysbacteriosis in the body intestinal, had a strong impact on the normal function of body.
Current commercially available livestock and poultry diarrhea curative poor effect.
Summary of the invention
The objective of the invention is to overcome the deficiency of existing production technology, propose a kind of heat clearing away, removing toxic substances, dysentery relieving effective, herbal medicine granule of clearing away heat to cure dysentery and preparation method thereof for safe green, no drug residue, convenient drug administration, the simple a kind of poultry of process equipment.
The present invention realizes that the technical scheme of purpose is:
The herbal medicine granule of clearing away heat to cure dysentery for a kind of poultry comprises following component and mass fraction thereof:
Radix Sophorae Flavescentis 10-20 part; Mahonia fortunei (Lindl.) Fedde 5-15 part;
Fructus Foeniculi 5-15 part; Radix et Rhizoma Thalictri 5-15 part;
Radix Aucklandiae 5-15 part; Flos Hibisci 5-15 part;
Fructus Terminaliae Billericae 5-15 part; Herba Pteridis Multifidae 5-10 part;
Radix Angelicae Sinensis 5-10 part; Radix Glycyrrhizae 5-10 part.
Damp and hot Sheng is added Rhizoma Coptidis 5-15 part on this basis.
Restless, poor appetite adds Radix Scutellariae 5-15 part on this basis.
Let out dysentery and heavily add Herba polygoni hydropiperis or Cortex Ailanthi 5-15 part.
A kind of poultry herbal medicine granule of clearing away heat to cure dysentery and preparation method thereof, step is:
By 3 times of amounts for Radix Angelicae Sinensis (w/v, as follows.) 70% ~ 75% alcohol solution dipping 24 hours, 100 ℃ are extracted 2 hours, filter; Add 1.5 times of amount 70% alcoholic solution for filtering residue, 100 ℃ are extracted 1.5 hours, filter merging filtrate; Reclaim ethanol, 60 ℃ concentrated, precipitate with ethanol;
By the water of 4 times of amounts for other a few herbs (w/v, as follows.) soak 2 hours, 100 ℃ are extracted 2 hours, filter; For filtering residue, add 100 ℃, the water of 2 times of amounts to extract 1.5 hours; Merging filtrate;
(3) merge (1) and the medicinal liquid (2) obtained, fully mix, filter, filtrate is concentrated into the thick paste that relative density is 1.35-1.39;
(4) add sucrose and/or the dextrin of 77 ~ 120% weight ratios of whole Chinese crude drug gross weights, 75% alcoholic solution is as wetting agent, and wet method is made soft material, and 17 mesh sieves are granulated;
(5) by the granule 65-75 ℃ of dry 2-3 hour obtained, 17 mesh sieve granulate, pack and get final product.(single dose is equivalent to the 25g Chinese crude drug.）
Side separates:
We be take Radix Sophorae Flavescentis as monarch drug, heat clearing and damp drying, parasite killing, diuresis.Main damp-heat dysentery; Discharging fresh blood stool.
With the Radix Aucklandiae, Fructus Terminaliae Billericae, when being classified as ministerial drug; Wherein, during Muxiangliqi is adjusted, drying dampness to eliminate phlegm; The Fructus Terminaliae Billericae heat-clearing and toxic substances removing, convergence is nourished blood, coordinating the actions of various ingredients in a prescription; Get the effect that Chinese angelica blood supplementing is invigorated blood circulation.
Take Mahonia fortunei (Lindl.) Fedde, Radix et Rhizoma Thalictri, Flos Hibisci, Fructus Foeniculi is adjuvant drug; Wherein, Mahonia fortunei (Lindl.) Fedde nourishing YIN and clearing away heat; The Radix et Rhizoma Thalictri heat clearing and damp drying, removing toxic substances; The Flos Hibisci clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling; Fructus Foeniculi stomach invigorating, circulation of qi promoting, the cold expelling of regulating the flow of vital energy.
With Herba Pteridis Multifidae, Radix Glycyrrhizae for making medicine; Wherein, Herba Pteridis Multifidae clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, the Radix Glycyrrhizae invigorating the spleen and replenishing QI, relieving cough and moistening lung, emergency removing toxic substances, be in harmonious proportion hundred medicines.
Chinese crude drug of the present invention except antibacterial, the sterilization, can also adjust the body physiological situation, reach treating both the principal and secondary aspects of a disease, effectively utilize the meridian distribution of property and flavor of Chinese crude drug and function to cure mainly.
The present invention adopts Chinese medicine west system, effective ingredient fully can not only be extracted, the adjuvant added is made granule can cover the intrinsic bitterness of medicine Chinese crude drug, improves mouthfeel and increases the compliance of poultry to medicine, and melting is good, bioavailability is high than powder, powder, pre-mixing agent; And in production process, dust is few, technique is simple, there is steady quality, transportation, store, carry, apply all more convenient, mechanization production, output is large, cost is low, organic solvent can be recycled repeatedly, sanitary standard also easily reaches.
Advantage of the present invention and beneficial effect are:
1, the present invention has innovated the herbal medicine granule new product of poultry by clearing away heat to cure dysentery, its Chinese crude drug coupling of respectively distinguishing the flavor of in filling a prescription, can heat clearing and damp drying, removing toxic substances dysentery relieving, strengthening the spleen to promote digestion, stomach function regulating antidiarrheal and use safe characteristics, fully demonstrated the advantage of compound Chinese medicinal preparation in the poultry clearing away heat to cure dysentery.
The interpolation of respectively the distinguish the flavor of coupling of Chinese medicine optimal proportion and the adjuvant 2, related in the present invention's formula, can cover medicine self bitterness, increases the compliance of poultry to medicine, reduce raiser's medication difficulty and loaded down with trivial details step, and melting is good, and bioavailability is high.Have use simply, characteristics easily and efficiently, be more suitable for the control of large-scale cultivation field livestock and poultry.
3, the Radix Angelicae Sinensis alcohol extraction the present invention relates to, it is complete that other flavor Chinese medicine combined extraction technologies have extracts active ingredients, and technique is simple, processing ease, relates to installations and facilities few, with low cost, is applicable to the multiple advantages such as large-scale production and industrialization.
The specific embodiment
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1:
Formula: (medical material gross weight 10 kg)
Radix Sophorae Flavescentis 1.0kg(10 part)
Mahonia fortunei (Lindl.) Fedde 0. 5kg(5 part)
Fructus Foeniculi 1.5kg(15 part)
Radix et Rhizoma Thalictri 0. 5kg(5 part)
Radix Aucklandiae 1.0kg(10 part)
Flos Hibisci 1.0kg(10 part)
Fructus Terminaliae Billericae 1.5kg(15 part)
Herba Pteridis Multifidae 1.0kg(10 part)
Radix Angelicae Sinensis 1.0kg(10 part)
Radix Glycyrrhizae 1.0kg(10 part)
(1) by 70% alcohol solution dipping of 3 liters 24 hours for Radix Angelicae Sinensis, 100 ℃ are extracted 2 hours, filter; Add 1.5 times of amount 70% alcoholic solution for filtering residue, 100 ℃ are extracted 1.5 hours, filter merging filtrate; Reclaim ethanol, 60 ℃ concentrated, precipitate with ethanol;
(2) by the water soaking of 36 liters 2 hours for other a few herbs, 100 ℃ are extracted 2 hours, filter; For filtering residue, add 100 ℃, the water of 2 times of amounts to extract 1.5 hours; Merging filtrate;
(3) merge (1) and the medicinal liquid (2) obtained, fully mix, filter, filtrate is concentrated into the thick paste that relative density is 1.35 ~ 1.39;
(4) with sucrose sucrose 5.5kg, dextrin 2.2kg, 75% alcoholic solution is as wetting agent, and wet method is made soft material, and 17 mesh sieves are granulated;
(5) by the granule 65-75 ℃ of dry 2-3 hour obtained, 17 mesh sieve granulate, every packing 50 g(are converted into medical material 25g), obtain.
Embodiment 2:
Formula: (10 kilograms of medical material gross weights)
Radix Sophorae Flavescentis 2.0kg(20 part)
Mahonia fortunei (Lindl.) Fedde 1.0kg(10 part)
Fructus Foeniculi 0.5kg (5 parts)
Radix et Rhizoma Thalictri 1.5kg(15 part)
Radix Aucklandiae 1.5kg(15 part)
Flos Hibisci 0.5kg(5 part)
Fructus Terminaliae Billericae 1.0kg(10 part)
Herba Pteridis Multifidae 0.5kg (5 parts)
Radix Angelicae Sinensis 0.5kg (5 parts)
Radix Scutellariae 0.5kg (5 parts)
Radix Glycyrrhizae 0.5kg (5 parts)
Preparation method comprises the steps:
(1) by 70% alcohol solution dipping of 1.5 liters 24 hours for Radix Angelicae Sinensis, 100 ℃ are extracted 2 hours, filter; Add 1.5 times of amount 70% alcoholic solution for filtering residue, 100 ℃ are extracted 1.5 hours, filter merging filtrate; Reclaim ethanol, 60 ℃ concentrated, precipitate with ethanol;
(2) by the water soaking of 38 kilograms 2 hours for other a few herbs, 100 ℃ are extracted 2 hours, filter; For filtering residue, add 100 ℃, the water of 2 times of amounts to extract 1.5 hours, filter; Merging filtrate;
(3) merge (1) and the medicinal liquid (2) obtained, fully mix, filter, filtrate is concentrated into the thick paste that relative density is 1.35 ~ 1.39;
(4) thick paste is with sucrose: 7.0kg, dextrin: 5.0 kg, and 75% alcoholic solution is as wetting agent, and wet method is made soft material, and 17 mesh sieves are granulated;
(5) by the granule 65-75 ℃ of dry 2-3 hour obtained, 17 mesh sieve granulate, pack (being equivalent to medical material 25g), obtains.
Embodiment 3:(medical material gross weight 10kg)
Formula:
Radix Sophorae Flavescentis 1.0kg (10 parts)
Mahonia fortunei (Lindl.) Fedde 1.5kg (15 parts)
Fructus Foeniculi 1.0kg (10 parts)
Radix et Rhizoma Thalictri 0.5kg (5 parts)
Radix Aucklandiae 0.5kg (5 parts)
Flos Hibisci 1. 5kg (15 parts)
Fructus Terminaliae Billericae 1.0kg (10 parts)
Herba Pteridis Multifidae 0.5kg (5 parts)
Radix Angelicae Sinensis 0.5kg (5 parts)
Rhizoma Coptidis 1.5kg (15 parts)
Radix Glycyrrhizae 0.5kg (5 parts)
The present embodiment preparation method:
(1) by 75% alcohol solution dipping of 1.5 liters 24 hours for Radix Angelicae Sinensis, 100 ℃ are extracted 2 hours, filter; Add 1.5 times of amount 70% alcoholic solution for filtering residue, 100 ℃ are extracted 1.5 hours, filter merging filtrate; Reclaim ethanol, 60 ℃ concentrated, precipitate with ethanol;
(2) by the water soaking of 38 kilograms 2 hours for other a few herbs, 100 ℃ are extracted 2 hours, filter; For filtering residue, add 100 ℃, the water of 2 times of amounts to extract 1.5 hours, filter; Merging filtrate;
(3) merge (1) and the medicinal liquid (2) obtained, fully mix, filter, filtrate is concentrated into the thick paste that relative density is 1.35 ~ 1.39;
(4) with sucrose sucrose 6kg, dextrin 4kg, 75% alcoholic solution is as wetting agent, and wet method is made soft material, and 17 mesh sieves are granulated;
(5) by the granule 65-75 ℃ of dry 2-3 hour obtained, 17 mesh sieve granulate, every packing 50 g(are converted into medical material 25g), obtain.
Embodiment 4:(medical material gross weight 10kg)
Formula:
Radix Sophorae Flavescentis 1.0kg (10 parts)
Mahonia fortunei (Lindl.) Fedde 0.5kg (5 parts)
Fructus Foeniculi 0.5kg (5 parts)
Radix et Rhizoma Thalictri 1.0kg (10 parts)
Radix Aucklandiae 1.0kg (10 parts)
Flos Hibisci 0. 5kg (5 parts)
Fructus Terminaliae Billericae 0. 5kg (5 parts)
Herba Pteridis Multifidae 0.5kg (5 parts)
Radix Angelicae Sinensis 0.5kg (5 parts)
Radix Glycyrrhizae 1.0kg (10 parts)
Herba polygoni hydropiperis 1.5 kg (15 parts)
Cortex Ailanthi 1.5 kg (15 parts)
(1) by 70% alcohol solution dipping of 1.5 liters 24 hours for Radix Angelicae Sinensis, 00 ℃ is extracted 2 hours, filters; Add 1.5 times of amount 70% alcoholic solution for filtering residue, 100 ℃ are extracted 1.5 hours, filter merging filtrate; Reclaim ethanol, 60 ℃ concentrated, precipitate with ethanol;
(2) by the water soaking of 38 liters 2 hours for other a few herbs, 100 ℃ are extracted 2 hours, filter; For filtering residue, add 100 ℃, the water of 2 times of amounts to extract 1.5 hours, filter; Merging filtrate;
(3) merge (1) and (2) medicinal liquid, fully mix, filter, filtrate is concentrated into the thick paste that relative density is 1.35 ~ 1.39;
(4) thick paste is with sucrose: 7.0kg, dextrin: 5.0 kg, and 75% alcoholic solution is as wetting agent, and wet method is made soft material, and 17 mesh sieves are granulated;
(5) by the granule 65-75 ℃ of dry 2-3 hour obtained, 17 mesh sieve granulate, pack (being equivalent to medical material 25g), obtains.
Embodiment 5:
Formula: (10 kilograms of medical material gross weights)
Radix Sophorae Flavescentis 1.5kg(20 part)
Mahonia fortunei (Lindl.) Fedde 1.0kg(10 part)
Fructus Foeniculi 0.5kg (5 parts)
Radix et Rhizoma Thalictri 1.0kg(15 part)
Radix Aucklandiae 1.0kg(15 part)
Flos Hibisci 0.5kg(5 part)
Fructus Terminaliae Billericae 1.0kg(10 part)
Herba Pteridis Multifidae 0.5kg (5 parts)
Radix Angelicae Sinensis 0.5kg (5 parts)
Radix Scutellariae 1.5kg (15 parts)
Radix Glycyrrhizae 0.5kg (5 parts)
Herba polygoni hydropiperis 0.5kg (5 parts)
Preparation method comprises the steps:
(1) by 70% alcohol solution dipping of 1.5 kilograms 24 hours for Radix Angelicae Sinensis, 100 ℃ are extracted 2 hours, filter; Add 1.5 times of amount 70% alcoholic solution for filtering residue, 100 ℃ are extracted 1.5 hours, filter merging filtrate; Reclaim ethanol, 60 ℃ concentrated, precipitate with ethanol;
(2) by the water soaking of 38 liters 2 hours for other a few herbs, 100 ℃ are extracted 2 hours, filter; For filtering residue, add 100 ℃, the water of 2 times of amounts to extract 1.5 hours, filter; Merging filtrate;
(3) merge (1) and (2) medicinal liquid, fully mix, filter, filtrate is concentrated into the thick paste that relative density is 1.35 ~ 1.39;
(4) thick paste is with sucrose: 7.0kg, dextrin: 5.0 kg, and 75% alcoholic solution is as wetting agent, and wet method is made soft material, and 17 mesh sieves are granulated;
(5) by the granule 65-75 ℃ of dry 2-3 hour obtained, 17 mesh sieve granulate, pack (being equivalent to medical material 25g), obtains.
Choose 400 pigs because of dysentery diarrhoea, Symptoms is: significantly diarrhoea occurs, the back of a bow hangs abdomen; Significantly dehydration, skeletonize, weakness; Body temperature drops to room temperature by height, before death lower than room temperature.It is divided into to two groups, organizes 1 and give medicine of the present invention, organize 2 to conventional antidysenteric (four yellow Zhili granules), usage and dosage is identical: 100g is to 200 kilograms, water, and mixed drink once a day, is concentratedly freely quoted, and is used in conjunction three days; Curative effect determinate standard: cure: indices returns to one's perfect health; Take a turn for the better: feces is shown in sclerosis, and feed improves, and the mental status is improved, and muscle power is recovered to some extent.) statistical result sees the following form:
| Numbering | Group | Total number of cases | Cure number of cases | The improvement number of cases | Without positive effect | Effective percentage | Cure rate |
| 1 | Medicine group of the present invention | 200 | 192 | 5 | 3 | 98.5% | 96.0% |
| 2 | Four yellow Zhili granule groups | 200 | 101 | 12 | 87 | 56.5% | 50.5% |
After administration group of the present invention medication, sick pig feed intake obviously rises, and it is normal that feces recovers, and each disease fades away, and as seen from the above table, medicine of the present invention is used for the treatment of pig dysentery and obtains good result, and effective percentage can reach 98.5%, and obvious effective rate reaches 96.0%.
Choose 2000 broiler because of dysentery diarrhoea, Symptoms is: significantly diarrhoea appears, and the yellow green of having loose bowels water, the rotten Fructus Lycopersici esculenti sample of some pictures, lose weight, and feed intake obviously descends, body temperature rise.It is divided into to two groups, organizes 1 and give medicine of the present invention, organize 2 to conventional antidysenteric (four yellow Zhili granules), usage and dosage is identical: 100g is to 200 kilograms, water, and mixed drink once a day, is concentratedly freely quoted, and is used in conjunction three days; Curative effect determinate standard: cure: indices returns to one's perfect health; Take a turn for the better: feces is shown in sclerosis, and feed improves, and the mental status is improved, and muscle power is recovered to some extent.Statistical result sees the following form:
| Numbering | Group | Total number of cases | Cure number of cases | The improvement number of cases | Without positive effect | Effective percentage | Obvious effective rate |
| 1 | Medicine group of the present invention | 1000 | 989 | 5 | 6 | 98.9% | 99.4% |
| 2 | Four yellow Zhili granule groups | 1000 | 686 | 60 | 254 | 68.6% | 74.6% |
After administration group of the present invention medication, sick pig feed intake obviously rises, and it is normal that feces recovers, and each disease fades away, and as seen from the above table, medicine of the present invention is used for the treatment of pig dysentery and obtains good result, and effective percentage can reach 98.9%, and obvious effective rate reaches 99.4%.
Claims (5)
1. the herbal medicine granule of clearing away heat to cure dysentery for poultry comprises following component and mass fraction thereof:
Radix Sophorae Flavescentis 10-20 part; Mahonia fortunei (Lindl.) Fedde 5-15 part;
Fructus Foeniculi 5-15 part; Radix et Rhizoma Thalictri 5-15 part;
Radix Aucklandiae 5-15 part; Flos Hibisci 5-15 part;
Fructus Terminaliae Billericae 5-15 part; Herba Pteridis Multifidae 5-10 part;
Radix Angelicae Sinensis 5-10 part; Radix Glycyrrhizae 5-10 part.
2. the herbal medicine granule of clearing away heat to cure dysentery for poultry according to claim 1, is characterized in that, also comprises Rhizoma Coptidis 5-15 part.
3. the herbal medicine granule of clearing away heat to cure dysentery for poultry according to claim 1, is characterized in that, also comprises Radix Scutellariae 5-15 part.
4. the herbal medicine granule of clearing away heat to cure dysentery for poultry according to claim 1, is characterized in that, also comprises Herba polygoni hydropiperis or Cortex Ailanthi 5-15 part.
5. the preparation method of the herbal medicine granule of clearing away heat to cure dysentery for poultry, step is:
(1) by 70% ~ 75% alcohol solution dipping of 3 times of amounts 24 hours for Radix Angelicae Sinensis, 100 ℃ are extracted 2 hours, filter; Add 1.5 times of amount 70% alcoholic solution for filtering residue, 100 ℃ are extracted 1.5 hours, filter merging filtrate; Reclaim ethanol, 60 ℃ concentrated, precipitate with ethanol;
(2) by the water soaking of 4 times of amounts 2 hours for other a few herbs, 100 ℃ are extracted 2 hours, filter; For filtering residue, add 100 ℃, the water of 2 times of amounts to extract 1.5 hours; Merging filtrate;
(3) merge (1) and the medicinal liquid (2) obtained, fully mix, filter, filtrate is concentrated into the thick paste that relative density is 1.35-1.39;
(4) add sucrose and/or the dextrin of 77 ~ 120% weight ratios of whole Chinese crude drug gross weights, 75% alcoholic solution is as wetting agent, and wet method is made soft material, and 17 mesh sieves are granulated;
(5) by the granule 65-75 ℃ of dry 2-3 hour obtained, 17 mesh sieve granulate, pack and get final product.
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| CN103877415A (en) * | 2014-03-15 | 2014-06-25 | 青岛绿曼生物工程有限公司 | Traditional Chinese medicine composition for treating dog and cat diarrhea and preparation method thereof |
| CN104436161A (en) * | 2014-11-12 | 2015-03-25 | 中国农业科学院哈尔滨兽医研究所 | Pteris multifida and colistin-containing compound drug for livestock and poultry |
| CN106880658A (en) * | 2015-12-15 | 2017-06-23 | 洛阳惠中兽药有限公司 | It is a kind of to treat Chinese medicine composition of avian colibacillosis and its preparation method and application |
| CN106334075A (en) * | 2016-11-07 | 2017-01-18 | 四会市恒星智能科技有限公司 | Traditional Chinese veterinary medicine for preventing and treating intestinal diseases of fragrant pigs and preparation method thereof |
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| CN102258635A (en) * | 2011-07-15 | 2011-11-30 | 山东省农业科学院畜牧兽医研究所 | Antibacterial Chinese medicine for veterinary use |
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| CN102258635A (en) * | 2011-07-15 | 2011-11-30 | 山东省农业科学院畜牧兽医研究所 | Antibacterial Chinese medicine for veterinary use |
Non-Patent Citations (4)
| Title |
|---|
| 中草药饲料添加剂在鸡生产中的应用;李亮, 王银东;《兽药与饲料添加剂》;20080131;第13卷(第1期);19－21 * |
| 张国红.按中草药对畜禽疾病病原体作用分类初探.《云南畜牧兽医》.1997,(第3期),34－35. |
| 按中草药对畜禽疾病病原体作用分类初探;张国红;《云南畜牧兽医》;19970331(第3期);34－35 * |
| 李亮, 王银东.中草药饲料添加剂在鸡生产中的应用.《兽药与饲料添加剂》.2008,第13卷(第1期),19－21. |
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