CN114099590A - Fermented Chinese herbal medicine preparation for preventing and treating livestock and poultry diarrhea and preparation method thereof - Google Patents
Fermented Chinese herbal medicine preparation for preventing and treating livestock and poultry diarrhea and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of Chinese herbal medicines for livestock and poultry, in particular to a fermented Chinese herbal medicine preparation for preventing and treating livestock and poultry diarrhea and a preparation method thereof. The fermented Chinese herbal medicine preparation comprises the following components in percentage by weight: 55-65% of a Chinese herbal medicine mixture and 35-45% of a yeast culture, wherein the Chinese herbal medicine mixture comprises white paeony root, callicarpa nudiflora, tangerine peel, bighead atractylodes rhizome, groundsel and divaricate saposhnikovia root. The invention has the advantages of good curative effect, quick effect, convenient use, simple production process and no toxic or side effect.
Description
Technical Field
The invention relates to the technical field of Chinese herbal medicines for livestock and poultry, in particular to a fermented Chinese herbal medicine preparation for preventing and treating livestock and poultry diarrhea and a preparation method thereof.
Background
In recent years, the breeding scale of livestock is continuously enlarged, but the problem of diarrhea of livestock in breeding production always troubles farmers, and as the diarrhea affects the health state of livestock, the livestock grows slowly, the feed conversion rate is reduced, even various diseases are caused, the economic benefit of a large-scale livestock farm is seriously affected, and great economic loss is caused.
Causes of diarrhea in livestock are many, and the causes are summarized as disease diarrhea and environmental diarrhea. Diseases caused by various pathogenic bacteria such as Escherichia coli, salmonella, paratyphoid and the like can cause diarrhea of livestock. Diseases caused by various viruses such as newcastle disease virus, avian influenza virus and the like can cause diarrhea of livestock. Moreover, diarrhea also often plays a significant role in diagnosing disease as a complication.
The climate environmental diarrhea refers to diarrhea caused by relatively strong stress reaction of livestock and poultry caused by severe change of feeding environment. When the sanitation and safety of feed (such as feeding raw soybean meal, mildewed feed and the like) and drinking water (water source is polluted and the like) are in problem, the digestive system of the livestock can be disturbed, and the diarrhea is shown.
Causes diarrhea of livestock and poultry: one is viral diarrhea; secondly, bacterial diarrhea; third, parasitic diarrhea; fourthly, the nutritional and metabolic diarrhea; fifthly, environmental stress diarrhea; sixthly, compensatory diarrhea and the like. The main symptoms are: diarrhea, watery or pasty feces, gray, yellow to white feces, occasionally brown, yellow brown or chicken droppings due to occult blood, with blood streak or purulent blood, fishy smell, emaciation, pale hair, coarse and disorderly hair, poor growth, mental withering, abdominal pain, tenesmus, and poor appetite.
The livestock diarrhea is a syndrome caused by intestinal toxins characterized by livestock diarrhea, is caused by various pathogenic factors, most of the existing medicines for preventing and treating the livestock diarrhea are western medicine preparations, traditional Chinese medicine powder and traditional Chinese medicine powder, mainly aim at bacterial diarrhea, and have certain effect but cause great side effect.
Chinese patent application CN201610901370.1 discloses a traditional Chinese medicine composition for preventing and treating livestock and poultry diarrhea, which comprises the following components in parts by weight: 4-8 parts of mulberry, 6-8 parts of medlar, 3-5 parts of poria cocos, 1-3 parts of liquorice, 4-8 parts of Nandina domestica, 6-8 parts of lily, 1-2 parts of fritillaria cirrhosa, 2-5 parts of loquat leaves, 1-3 parts of snakegourd fruit seeds, 1-2 parts of snakegourd fruit leaves, 6-8 parts of perilla fruits, 4-6 parts of almonds, 3-6 parts of wild chrysanthemum flowers, 2-4 parts of honeysuckle flowers, 5-8 parts of seaweed, 5-10 parts of schisandra chinensis, 4-6 parts of cynanchum glaucescens, 3-7 parts of Chinese cabbage roots, 3-5 parts of clam shell powder, 3-6 parts of isatis roots and 2-6 parts of ephedra. The traditional Chinese medicine composition is prepared from natural medicinal materials, is warm but not dry, pungent but not scattered, safe and effective, has the effects of clearing away heat and toxic materials, ventilating and smoothing lung and relieving cough, and reducing phlegm and asthma, has a good treatment effect on exogenous cough, upper respiratory infection and bronchitis, and has no side effect. However, the traditional Chinese medicine composition has numerous raw materials, an action mechanism is unclear, the effect is unstable, and the effect of preventing and treating diarrhea of the composition is not verified in texts.
Chinese patent application CN201810787483.2 discloses a Chinese herbal compound for preventing and treating livestock and poultry diarrhea and a preparation process thereof, wherein the Chinese herbal compound is prepared from the following components in parts by weight: 25-30 parts of dandelion, 20-25 parts of glabrous greenbrier rhizome, 25-30 parts of Chinese violet, 20-25 parts of wild chrysanthemum flower and 25-30 parts of dahurian patrinia herb. The preparation method comprises the following steps: weighing the raw materials according to the parts by weight, screening, carrying out ultra-micro freezing and crushing on the raw materials, and crushing to 800-mesh powder and 1000-mesh powder; adding 1% sodium hydroxide and water, soaking at 80 deg.C for 60 min, performing solid-liquid separation with horizontal screw centrifuge and butterfly centrifuge, respectively, and adjusting pH of the extractive solution to 3.5-4.0 with dilute hydrochloric acid. Concentrating the above extractive solution with triple effect concentrator to density of 1.05-1.10, centrifuging, filtering, spray drying the concentrated solution to obtain water soluble product or adsorbing with granular silicon dioxide, and drying with paddle spiral drying method to obtain granule powder. The invention has the functions of clearing away heat and toxic material and resisting inflammation, can obviously inhibit common pathogenic bacteria escherichia coli of pigs and chickens, and can replace antibiotics to prevent and treat diarrhea of livestock and poultry. However, the traditional Chinese medicine composition has slow effect, complex preparation process and needs to be further improved in curative effect.
Therefore, it is very necessary to develop a fermented Chinese herbal medicine preparation for preventing and treating livestock and poultry diarrhea and a preparation method thereof, which can solve the above technical problems.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a fermented Chinese herbal medicine preparation for preventing and treating mixed infection of livestock and poultry and a preparation method thereof, wherein the fermented Chinese herbal medicine preparation has the advantages of good curative effect, quick response, convenient use, simple production process and no toxic or side effect.
The invention is realized by the following technical scheme:
a fermented Chinese herbal medicine composition comprises the following components in percentage by weight: 55-65% of a Chinese herbal medicine mixture and 35-45% of a yeast culture, wherein the Chinese herbal medicine mixture comprises white paeony root, callicarpa nudiflora, tangerine peel, bighead atractylodes rhizome, groundsel and divaricate saposhnikovia root.
White peony root: the bitter, sour and cold entering liver, spleen and lung channels, clearing and nourishing liver blood, astringing liver and relieving pain;
callicarpa nudiflora: bitter and cold entering lung and stomach channels, dispelling blood stasis and relieving swelling, astringing and stopping bleeding;
groundsel: bitter, slightly cold and entering liver, lung and large intestine channels, clearing away heat and toxic materials, removing liver heat, improving eyesight, and removing dampness and heat;
dried orange peel: pungent and bitter with warm property enter lung, spleen and stomach meridians to regulate spleen qi, eliminate dampness and resolve phlegm;
white atractylodes rhizome: sweet and bitter taste enters spleen and stomach channels to strengthen spleen and eliminate dampness;
wind prevention: pungent and sweet taste warm slightly enters liver, spleen and bladder meridians to dispel wind and remove dampness.
Liver wood can inhibit spleen soil and cause spleen deficiency and excessive dampness, so stool is thin, sour, smelly and sticky; liver depression leading to disharmony of qi and blood, water retention and blood circulation disorder; spleen failing to transport and transform due to liver exuberance and spleen deficiency, and dampness stagnating internally; therefore, the spleen should be tonified, the spleen qi should be dredged, the liver and spleen function should be recovered to normal state, and the gastrointestinal function should be recovered to normal state; the enteropathogenic toxin, particularly the endotoxin in the spleen and the stomach, is more effectively cleaned, the harmful microorganisms in the intestinal tract are killed, and the mass propagation of beneficial microorganisms is promoted; the mesenteric lymph nodes and the lymph follicles are stimulated, an immune barrier is established, the mucosal antibody IgA proliferation is promoted, normal flora can be recovered, the gastrointestinal tract of the livestock can be healthy, and the livestock can grow healthily.
Preferably, the Chinese herbal medicine mixture comprises the following components in parts by weight: 9-16 parts of white paeony root, 9-16 parts of callicarpa nudiflora, 8-16 parts of dried orange peel, 9-16 parts of bighead atractylodes rhizome, 9-16 parts of groundsel and 9-12 parts of divaricate saposhnikovia root.
Preferably, the yeast culture comprises saccharomycete and a basic nutrient.
More preferably, the yeast culture further comprises at least one of lactobacillus, bacillus subtilis, and bacillus butyricum.
More preferably, the primary nutrients include biological glycolytic enzymes, vitamins, amino acids, and peptones.
More preferably, the biological glycolytic enzyme comprises at least one of cellulase, protease, lipase and phytase.
More preferably, the yeast culture is a yeast culture of idetide de, purchased from ludwi bio environmental protection technology (suria) ltd.
The invention also relates to a fermented Chinese herbal medicine preparation which comprises the fermented Chinese herbal medicine composition.
The invention also relates to a preparation process of the fermented Chinese herbal medicine preparation, which comprises the following steps:
(1) respectively crushing the white paeony root, the callicarpa nudiflora, the dried orange peel, the bighead atractylodes rhizome, the groundsel and the divaricate saposhnikovia root into coarse powder of 100-mesh and 200-mesh, and mixing to obtain a Chinese herbal medicine mixture;
(2) mixing the Chinese herbal medicine mixture and yeast culture for 15-20min, and fermenting together for 10-15 days to obtain fermented Chinese herbal medicine preparation.
Preferably, the preparation process of the fermented Chinese herbal medicine preparation comprises the following steps:
(1) respectively crushing the white paeony root, the callicarpa nudiflora, the dried orange peel, the bighead atractylodes rhizome, the groundsel and the divaricate saposhnikovia root into coarse powder of 100-mesh and 200-mesh, and mixing to obtain a Chinese herbal medicine mixture;
(2) mixing the Chinese herbal medicine mixture and yeast culture for 15-20min, and fermenting together for 10-15 days to obtain fermented Chinese herbal medicine preparation.
The invention also relates to the application of the fermented Chinese herbal medicine composition or the fermented Chinese herbal medicine preparation prepared by the preparation process in preparing the medicine for preventing and treating livestock and poultry diarrhea.
The main reasons for causing the livestock and poultry diarrhea are as follows: one is viral diarrhea; secondly, bacterial diarrhea; third, parasitic diarrhea; fourthly, the nutritional and metabolic diarrhea; fifthly, environmental stress diarrhea; sixthly, compensatory diarrhea and the like. The main symptoms are: diarrhea, watery or pasty feces, gray, yellow to white feces, occasionally brown, yellow brown or chicken droppings due to occult blood, with blood streak or purulent blood, fishy smell, emaciation, pale hair, coarse and disorderly hair, poor growth, mental withering, abdominal pain, tenesmus, and poor appetite.
The invention has the beneficial effects that:
the fermented Chinese herbal medicine composition has a reasonable formula. The fermented Chinese herbal medicine composition is prepared by taking one or more probiotics in Chinese herbal medicine and intestinal probiotic flora as strains, simulating the intestinal environment of an animal body and the digestive decomposition process of Chinese herbal medicine components in the animal body in vitro by using a microecology and bionics method and a biological grafting mode, biologically converting the effective components of the Chinese herbal medicine, converting macromolecular substances of the Chinese herbal medicine into small molecular components which can be directly absorbed by the intestinal tract of the animal body through microorganisms, and enabling the Chinese herbal medicine to become a novel medicine with rapid absorption and quantitative curative effect.
According to the formula compatibility principle of the traditional Chinese medicine composition, the effects of clearing damp and stopping diarrhea, and tonifying spleen and nourishing liver are achieved, the traditional Chinese medicine rhizoma atractylodis macrocephalae in the formula is sweet and bitter in taste and warm in nature, and can tonify spleen and dry dampness to treat soil deficiency; the ministerial drug is Callicarpa nudiflora, is bitter and cold in taste, and can astringe to stop bleeding, dissipate blood stasis and relieve swelling; groundsel, bitter in taste and cold in nature, can clear away heat and toxic materials, and remove dampness and heat; white peony root, bitter and sour in taste, can soften liver, relieve spasm and alleviate pain to suppress liver hyperactivity; the dried orange peel serving as an adjuvant drug is pungent, bitter and warm in taste, and can regulate qi, eliminate dampness, activate spleen and harmonize stomach; the medicine has divaricate saposhnikovia root, pungent and bitter in taste and warm in property, can disperse liver depression, regulate spleen qi, inhibit liver exuberance, tonify spleen and eliminate dampness, relieve spasm and pain, eliminate dampness and stop diarrhea. The purposes of clearing damp and checking diarrhea, and tonifying spleen and liver are achieved together.
The medicines are mixed together, so that the effects of clearing damp and stopping diarrhea, and tonifying spleen and liver are achieved; the traditional Chinese medicine has the advantages of wide source, environmental protection, low cost, quick curative effect, high cure rate, no medicine residue and no toxic or side effect.
The fermented Chinese herbal medicine preparation is convenient to use, simple in preparation process and beneficial to industrial production.
Detailed Description
The invention will be further described with reference to specific embodiments, and the advantages and features of the invention will become apparent as the description proceeds. These examples are illustrative only and do not limit the scope of the present invention in any way. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention, and that such changes and modifications may be made without departing from the spirit and scope of the invention.
The yeast cultures in the following examples are yeast cultures derived from Reid bioscience environmental protection technology (Iris lactea) Inc.
Example 1
The formula proportion is as follows: 20g of white paeony root, 15g of callicarpa nudiflora, 10g of dried orange peel, 30g of bighead atractylodes rhizome, 15g of groundsel and 10g of divaricate saposhnikovia root.
The sufficient components are inspected conventionally, crushed into 100 meshes and mixed evenly for 15 minutes to obtain the Chinese herbal medicine mixture. Adding 65g of the Chinese herbal medicine mixture into 35g of the yeast culture, uniformly mixing for 15 minutes, fermenting for 10 days together, finally preparing into a fermented Chinese herbal medicine preparation, and subpackaging for later use after the inspection is qualified.
Example 2
The formula proportion is as follows: 25g of white paeony root, 20g of callicarpa nudiflora, 15g of dried orange peel, 35g of bighead atractylodes rhizome, 20g of groundsel and 15g of divaricate saposhnikovia root.
The sufficient components are inspected conventionally, crushed into 200 meshes and mixed uniformly for 20 minutes to obtain the Chinese herbal medicine mixture. Adding 38g of yeast culture into 62g of the Chinese herbal medicine mixture, uniformly mixing for 15 minutes, fermenting for 15 days together, finally preparing into a fermented Chinese herbal medicine preparation, and subpackaging for later use after the inspection is qualified.
Example 3
The formula proportion is as follows: 30g of white paeony root, 25g of callicarpa nudiflora, 20g of dried orange peel, 40g of bighead atractylodes rhizome, 25g of groundsel and 20g of divaricate saposhnikovia root.
The sufficient components are inspected conventionally, crushed into 150 meshes and mixed evenly for 15 minutes to obtain the Chinese herbal medicine mixture. Adding 38g of yeast culture into 62g of the Chinese herbal medicine mixture, uniformly mixing for 15 minutes, fermenting for 12 days together, finally preparing into a fermented Chinese herbal medicine preparation, and subpackaging for later use after the inspection is qualified.
Example 4
The formula proportion is as follows: 35g of white paeony root, 30g of callicarpa nudiflora, 25g of dried orange peel, 45g of bighead atractylodes rhizome, 30g of groundsel and 25g of divaricate saposhnikovia root.
The sufficient components are inspected conventionally, crushed into 100 meshes and mixed evenly for 15 minutes to obtain the Chinese herbal medicine mixture. Adding 38g of yeast culture into 62g of the Chinese herbal medicine mixture, uniformly mixing for 15 minutes, fermenting for 10 days together, finally preparing into a fermented Chinese herbal medicine preparation, and subpackaging for later use after the inspection is qualified.
Example 5
The formula proportion is as follows: 40g of white paeony root, 35g of callicarpa nudiflora, 30g of dried orange peel, 50g of bighead atractylodes rhizome, 35g of groundsel and 30g of divaricate saposhnikovia root.
The sufficient components are inspected conventionally, crushed into 100 meshes and mixed uniformly for 20 minutes to obtain the Chinese herbal medicine mixture. Adding 60g of the Chinese herbal medicine mixture into 40g of the yeast culture, uniformly mixing for 15 minutes, fermenting for 15 days together, finally preparing into a fermented Chinese herbal medicine preparation, and subpackaging for later use after the inspection is qualified.
Example 6
The formula proportion is as follows: 45g of white paeony root, 40g of callicarpa nudiflora, 35g of dried orange peel, 55g of bighead atractylodes rhizome, 40g of groundsel and 35g of divaricate saposhnikovia root.
The sufficient components are inspected conventionally, crushed into 100 meshes and mixed evenly for 15 minutes to obtain the Chinese herbal medicine mixture. Adding 60g of the Chinese herbal medicine mixture into 40g of the yeast culture, uniformly mixing for 20 minutes, fermenting for 13 days together, finally preparing into a fermented Chinese herbal medicine preparation, and subpackaging for later use after the inspection is qualified.
Example 7
The formula proportion is as follows: 50g of white paeony root, 45g of callicarpa nudiflora, 40g of dried orange peel, 60g of bighead atractylodes rhizome, 45g of groundsel and 40g of divaricate saposhnikovia root.
The sufficient components are inspected conventionally, crushed into 100 meshes and mixed uniformly for 20 minutes to obtain the Chinese herbal medicine mixture. Adding 60g of the Chinese herbal medicine mixture into 40g of the yeast culture, uniformly mixing for 15 minutes, fermenting for 14 days together, finally preparing into a fermented Chinese herbal medicine preparation, and subpackaging for later use after the inspection is qualified.
Example 8
The formula proportion is as follows: 55g of white paeony root, 50g of callicarpa nudiflora, 45g of dried orange peel, 65g of bighead atractylodes rhizome, 50g of groundsel and 45g of divaricate saposhnikovia root.
The sufficient components are inspected conventionally, crushed into 100 meshes and mixed evenly for 15 minutes to obtain the Chinese herbal medicine mixture. Adding 60g of the Chinese herbal medicine mixture into 40g of the yeast culture, uniformly mixing for 15 minutes, fermenting for 10 days together, finally preparing into a fermented Chinese herbal medicine preparation, and subpackaging for later use after the inspection is qualified.
Example 9
The formula proportion is as follows: 60g of white paeony root, 55g of callicarpa nudiflora, 50g of dried orange peel, 70g of bighead atractylodes rhizome, 55g of groundsel and 50g of divaricate saposhnikovia root.
The sufficient components are inspected conventionally, crushed into 100 meshes and mixed evenly for 15 minutes to obtain the Chinese herbal medicine mixture. Adding 55g of the Chinese herbal medicine mixture into 45g of the yeast culture, uniformly mixing for 15 minutes, fermenting for 10 days together, finally preparing into a fermented Chinese herbal medicine preparation, and subpackaging for later use after the inspection is qualified.
Example 10
The formula proportion is as follows: 60g of white paeony root, 60g of callicarpa nudiflora, 55g of dried orange peel, 75g of bighead atractylodes rhizome, 60g of groundsel and 55g of divaricate saposhnikovia root.
The sufficient components are inspected conventionally, crushed into 100 meshes and mixed evenly for 15 minutes to obtain the Chinese herbal medicine mixture. Adding 55g of the Chinese herbal medicine mixture into 45g of the yeast culture, uniformly mixing for 15 minutes, fermenting for 10 days together, finally preparing into a fermented Chinese herbal medicine preparation, and subpackaging for later use after the inspection is qualified.
Comparative example 1
The difference from the example 1 is only that the dosage and the proportion of each component are different, and the rest conditions are the same, and the concrete conditions are as follows:
the formula proportion is as follows: 14g of white paeony root, 28g of callicarpa nudiflora, 5g of dried orange peel, 28g of bighead atractylodes rhizome, 5g of groundsel and 20g of divaricate saposhnikovia root.
Comparative example 2
The differences from the example 1 are that the total mass of callicarpa nudiflora, bighead atractylodes rhizome and groundsel is unchanged, the callicarpa nudiflora is not contained, and the mass ratio of the bighead atractylodes rhizome to the groundsel is unchanged, and the specific mass ratio is as follows:
the formula proportion is as follows: 20g of white peony root, 10g of dried orange peel, 40g of bighead atractylodes rhizome, 20g of groundsel and 10g of divaricate saposhnikovia root.
Comparative example 3
The differences from the example 1 are only that the total mass of callicarpa nudiflora, bighead atractylodes rhizome and groundsel is unchanged, the bighead atractylodes rhizome and groundsel are not contained, and only callicarpa nudiflora is contained, and the specific is as follows:
the formula proportion is as follows: 20g of white paeony root, 60g of callicarpa nudiflora, 10g of dried orange peel and 10g of divaricate saposhnikovia root.
Examples of the effects of the invention
The usage and dosage of the fermented Chinese herbal medicine preparation are as follows: the fermented Chinese herbal medicine preparation is added according to the amount of 0.5-1% of the full price material, and is used for 5-10 days.
The dosages of the drugs in the same application cases are the same.
Application example 1
Address: wangzhi of pig farm in Jiangxi Ganzhou city Nankang region of Jiangxi province
In 20 days in 2018, 4 months, 600 sows are fed by Wangzhi, 869 fat pigs are fed by Wangzhi, the feed intake of the whole fat pig is poor, a small number of sows have mastitis, the whole pig group draws thin manure, the watery manure is common, and the watery manure is also yellow white, yellow green and feed with end digestion in the thin manure. Swinery shows rough and disorderly fur, squint eyes and conjunctival flush. The 5 th and 12 th period of the test proves that the pig transmissible gastroenteritis, the rotavirus infection, the ileitis and other infections are confirmed, and the Chinese herbal medicine powder (such as antipyretic and antiphlogistic powder, Yinfusan and the like), the sulfanilamide-2-methoxypyrimidine, the doxycycline, the florfenicol and the like have no obvious effect. On day 28 of 5 months, 600 diarrhea sows and 800 diarrhea fat pigs were randomly divided into 4 groups of 150 sows and 200 fat pigs each. The products of the invention of example 1 and the comparative examples 1 to 3 are respectively added according to 1 percent of the complete feed for 10 days. On the 7 th day, the sow group and the fat pig group in the example 1 have good spirit, improved feces, increased feed intake, slowly improved mastitis, vigorous milk production, red and bright eyes, ruddy fur and 100 percent of diarrhea cure rate; comparative example 1 group 20 sows and 32 fat pigs showed no improvement in diarrhea, and the cure rate of diarrhea was 85.14%; comparative example 2 groups of 45 sows and 53 fat pigs have no improvement on diarrhea, and the cure rate of the diarrhea is 72 percent; comparative example 3 no improvement was seen in diarrhea of 56 sows and 71 fat pigs, and the cure rate of diarrhea was 63.71%. The product of the invention has the advantages of reliable effect on preventing and treating the infection of the transmissible gastroenteritis, rotavirus, ileitis and the like of the swinery, no toxic or side effect after use, no drug residue and low cost, and is a safe, green and environment-friendly fermented Chinese herbal medicine preparation.
Application example 2
Address: special beef cattle household of Huichang county of Jiangxi province
In 23 days 6 and 6 months in 2017, 546 heads of certain beef cattle are raised, and since Yuan month in 2017, the beef cattle in the beef cattle group show that the feed intake is uneven, the time is high and the time is low, and the feed intake is reduced; diarrhea and softening feces; depression; attenuation of ruminal rumination; dry oral mucosa, orbital depression; the foot odor is easy to cause laminitis and the like; the mixed infection of bovine transmissible gastroenteritis, salmonella, parasite and beef cattle chronic acidosis is diagnosed by animal quarantine analysis laboratory of animal medical department of Jiangxi agricultural university. The product of the invention in the embodiment 3 is added according to 1 percent of the full price material and is used for 10 days continuously. Then, the feed intake and the feces of the whole cattle are observed to be recovered to be normal, the feed intake is gradually increased, the feces are formed, eyes are clear and bright, oral mucosa is pink and wet, the mental condition is improved, rumination is also recovered to be normal, rumination is performed 12-14 times every day, and each time is 40-50 minutes, so that the product of the invention has a good effect on mixed infection of transmissible gastroenteritis, salmonella, parasite and chronic acidosis of beef cattle, and the healthy fattening of the beef cattle is guaranteed, therefore, the product of the invention is a safe, green and environment-friendly fermented Chinese herbal medicine preparation.
Application example 3
Address: liu in milk goat farm in Wenchang city, Hainan province
The milk goat is bred by 3214 Liu in 10-8 days 2015, the whole milk goat is poor in food intake, yellow white or grey green thin manure is drawn, the milk yield is unsatisfactory, the produced goat flock is thinned, the fur is rough, the eye is squinted, the eye conjunctiva is flush, and rotavirus infection, salmonellosis and parasite infection are diagnosed by animal medicine laboratories of southern China university of agriculture. The product of the embodiment 4 of the invention is added according to 1 percent of the full price material for 10 days continuously. After the medicine is used, the milk goat flock is observed to have good spirit, improved excrement, obviously increased milk yield, increased feed intake, vigorous milk production, bright eyes and ruddy fur. The product of the invention has the advantages of effective prevention and treatment of rotavirus, salmonella and parasite mixed infection of the milk goats, no toxic or side effect after use, no drug residue, low cost and high effective protection rate, and is a safe, green and environment-friendly fermented Chinese herbal medicine preparation.
Application example 4
Address: Lu-Chi chicken farm in Ningdu county of Jiangxi province
12698 feathers of 78-day-old Sanhuang chickens are bred in the eggs in 2018, 5 and 12 days, 12698 feathers of 78-day-old Sanhuang chickens are bred in some chickens in 2018, 2 and 10 days in 2018, the chickens have newcastle diseases and colibacillosis complicated by coccidiosis and are basically cured at present, but some 1/3 chickens have poor spirit, the excrement is soft, the feathers are fluffy, the eyelid surfaces and two feet have no sub-health symptoms such as bloody color and uneven growth; a small part of chickens have watery excrement, and the water is added into the chickens in 2018 in 5 months and 15 days according to the proportion of 1% of daily ration by using the product of the embodiment 5 of the invention for 10 days continuously. The chickens are observed for 20 days, the spirit is good, the feces are improved, the feathers are moist, the reaction is sensitive, the growth is active, and the growth is uniform until the chickens are slaughtered. The product of the invention has the advantages of improving the sub-health of the chicken and preventing and treating the diarrhea of the chicken, no toxic or side effect after use, no drug residue, low cost and high effective protection rate, and is a safe, green and environment-friendly fermented Chinese herbal medicine preparation.
Application example 5
Address: guo in certain duck breeding base of Sihui in Guangdong province
In 20 days in 3 months in 2017, 74874 feathers of laying ducks of 248 days old are bred in Guo, the laying rate is 65%, laying individuals are small, laying ducks are thin all the time since the laying ducks are laid, the feed intake is low, 0.3 catties of feed are fed to each feather duck on average, the ducks are thin, the feathers are fierce and thin, the whole duck group is in a sub-health state, the obvious resistance is low, and in order to improve the sub-health state of the duck group, the product of the embodiment 2 of the invention is added according to 1% of the duck complete feed and is continuously used for 10 days. The duck group is observed for 25 days, the spirit is improved, the excrement is improved, the laying rate is obviously increased to more than 85%, the feed intake is increased, the average amount of feather is more than 0.33 jin per feather duck, the feather is moist, the response is sensitive, and the growth is active. The product of the invention has the advantages of improving the sub-health of the duck and resisting the diarrhea of the duck, no toxic or side effect after use, no drug residue, low cost and high effective protection rate, and is a safe, green and environment-friendly fermented Chinese herbal medicine preparation.
Application example 6
Address: wangzou laying hen production base on the Shangzhou of Nanchang county in Jiangxi province
In 2019, in Wang, a laying hen of 41 days old is bred, from 3 months, the feed intake of a chicken flock is reduced, the chicken flock is withered and gradually thinned, white green thin manure is pulled, blood filaments are in the manure, bloody stool is pulled, a fishy smell in a henhouse appears, Wang considers that the chicken suffers from bacterial diseases such as colibacillosis, salmonellosis, clostridium welchii disease and the like, then poultry colibacillosis, enrofloxacin and mequindox are mixed for 5-7 days, but the effect is not very obvious, 568 feathers die, and then the manure is collected to an animal medicine laboratory veterinary analysis laboratory of Jiangxi agricultural university to be tested, and the result is avian epidemic diarrhea, colibacillosis, salmonella and coccidiosis. The product of the invention in example 9 is added according to 1 percent of daily ration immediately, and is used for 10 days continuously, the blood feces is less on the third day of medication, and the feces turns from thin to soft, and the feces turns better and stops death after the seventh day. The product of the invention has the advantages of no toxic or side effect after being used, no drug residue, low cost and high effective protection rate, and is a safe, high-efficiency, green, environment-friendly and anti-avian diarrhea fermented Chinese herbal medicine preparation.
Practical example 7
Address: chen of special household for goose raising in Yongfeng county of Jiangxi province
Buying goose 6000 feather in 2019 in 4-month and 2-day, and getting depressed spirit, sleepiness, necking down, weakness of feet, slow movement, poor appetite, and serous secretion flowing out of eyes and nose in 4-month and 14-day months; yellow-green dilute manure; the anus pollutes the feces. The cesarean examination shows fibrous pericarditis, perihepatitis and ballooning disease; arthritis, arthrocele, liver earthy yellow, bleeding spots with different sizes on the surface, lung, spleen and kidney swelling and bleeding and the like, and finally the mixed infection of goose infectious serositis, gosling viral hepatitis and goose salmonella diseases is confirmed. The gosling viral hepatitis refined serum is injected immediately, and the product of the invention example 10 is added according to 1 percent of the complete feed for 10 days continuously. The death is greatly reduced except the death with the symptoms of opisthotonus, head bending, neck tilting and general spastic tetany in the second day of administration, and the death is stopped in the fifth day, and the recovery is basically realized. The product of the invention has the advantages of no toxic or side effect after being used, no drug residue, low cost and high effective protection rate, and is a safe, efficient, green and environment-friendly fermented Chinese herbal medicine preparation.
The above detailed description is specific to one possible embodiment of the present invention, and the embodiment is not intended to limit the scope of the present invention, and all equivalent implementations or modifications without departing from the scope of the present invention should be included in the technical scope of the present invention.
Claims (10)
1. A fermented Chinese herbal medicine composition is characterized by comprising the following components in percentage by weight: 55-65% of a Chinese herbal medicine mixture and 35-45% of a yeast culture, wherein the Chinese herbal medicine mixture comprises white paeony root, callicarpa nudiflora, tangerine peel, bighead atractylodes rhizome, groundsel and divaricate saposhnikovia root.
2. The fermented Chinese herbal medicine composition according to claim 1, wherein the Chinese herbal medicine mixture comprises the following components in parts by weight: 9-16 parts of white paeony root, 9-16 parts of callicarpa nudiflora, 8-16 parts of dried orange peel, 9-16 parts of bighead atractylodes rhizome, 9-16 parts of groundsel and 9-12 parts of divaricate saposhnikovia root.
3. The fermented herbal composition of claim 1, wherein the yeast culture comprises saccharomycete and a basic nutrient.
4. The fermented herbal composition of claim 3, wherein the yeast culture further comprises at least one of Lactobacillus, Bacillus subtilis, and Bacillus butyricum.
5. The fermented herbal composition of claim 3, wherein the essential nutrients include biological glycolytic enzymes, vitamins, amino acids and peptones.
6. The fermented herbal composition of claim 5, wherein the biofermentation enzyme comprises at least one of cellulase, protease, lipase and phytase.
7. A fermented herbal formulation, comprising the fermented herbal composition of any one of claims 1-6.
8. A process for preparing a fermented herbal formulation of claim 7, comprising the steps of:
(1) pulverizing radix Paeoniae alba, folium Callicarpae Formosanae, pericarpium Citri Tangerinae, Atractylodis rhizoma, Concha Haliotidis and radix Saposhnikoviae, and mixing to obtain Chinese herbal mixture;
(2) mixing the Chinese herbal medicine mixture and the yeast culture, and fermenting to obtain the fermented Chinese herbal medicine preparation.
9. The process of claim 8, comprising the steps of:
(1) respectively crushing the white paeony root, the callicarpa nudiflora, the dried orange peel, the bighead atractylodes rhizome, the groundsel and the divaricate saposhnikovia root into coarse powder of 100-mesh and 200-mesh, and mixing to obtain a Chinese herbal medicine mixture;
(2) mixing the Chinese herbal medicine mixture and yeast culture for 15-20min, and fermenting together for 10-15 days to obtain fermented Chinese herbal medicine preparation.
10. Use of the fermented Chinese herbal medicine composition of any one of claims 1 to 6, the fermented Chinese herbal medicine preparation of claim 7 or the fermented Chinese herbal medicine preparation prepared by the preparation process of any one of claims 8 to 9 in preparation of a medicament for preventing and treating diarrhea of livestock and poultry.
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