CN104012807A - Antiviral compound vitamin premix feed preparation for livestock as well as preparation method and application of preparation - Google Patents
Antiviral compound vitamin premix feed preparation for livestock as well as preparation method and application of preparation Download PDFInfo
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Abstract
The invention discloses an antiviral compound vitamin premix feed preparation for livestock. The antiviral compound vitamin premix feed preparation for livestock consists of the following ingredients in parts by weight: 25-28 parts of vitamins, 10-14 parts of amino acid, 44.5-56 parts of polysaccharides, 8-12 parts of a traditional Chinese medicine extract, and 1-1.5 parts of an antitackiness agent. The invention aims at providing preparation for the antiviral compound vitamin premix feed preparation for livestock, which promotes development of immune organs of the livestock by inhibiting virus reproduction, regulates active immunologic functions, participates in immune reaction of the body, strengthens immunity of the body and induces the body to quickly generate interferon, has functions of quickly improving a non-specific immune function of the livestock body, improving disease resistance of the livestock and efficiently resisting stress, as well as a preparation method and application of the antiviral compound vitamin premix feed preparation for livestock.
Description
Technical field
The present invention relates to animal feed additive field, particularly antiviral B B-complex premixed feed preparation for a kind of livestock and poultry, and its preparation method and application.
Background technology
Viral disease is the disease of the headache of current livestock and poultry breeding industry, although traditional antiviral Western medicine has certain effect, but in order to ensure animal food safety, protect the health of people, China just issued " about the emergency notice of checking the antiviral drugs such as amantadine " in 2005, clearly provide against sale and the use of the antiviral veterinary drugs such as amantadine, Ribavirin, moroxydine.The current medicines such as Chinese herb on the prevention, interferon, immunoglobulin (Ig), ASON and ribozyme of generally taking are prevented and treated, but generally all exist, curative effect is indefinite, use cost is high, easily produce the drawbacks such as drug resistance, therefore really there is no very good way for the clinical treatment of virosis.
Chinese Patent Application No. CN201210390810.3 discloses a kind of chick toxic removing soup and manufacture thereof, using method, it mainly adopts Radix Codonopsis, the Radix Astragali, dandelion, honeysuckle, Radix Isatidis, folium isatidis, a kind of toxic removing soup prepared by Radix Glycyrrhizae, toad, for strengthening the immunity of chick, antibiotic pure Chinese medicinal preparation as an alternative.
Chinese Patent Application No. CN201110094957.3 disclose a kind of livestock composite premix compound containing traditional Chinese medicine ingredients and, it mainly adopts the mix preparation of multivitamin, amino acid and the Chinese medical extract using the Radix Astragali, hawthorn, Radix Isatidis and Radix Glycyrrhizae as primary raw material, for replenishing vitamins, amino acid, have stomach invigorating nourishing the stomach, antiviral, strengthen the features such as immunity.
But mostly anti-virus ability is poor, slow, the shortcoming such as consumption is large takes effect for the feed addictive with antiviral Chinese medicine preparation of the prior art.
Summary of the invention
The object of the present invention is to provide a kind of by suppressing copying of virus, promote fowl poultry immune allelotaxis, improve livestock and poultry resistance against diseases, antiviral B B-complex premixed feed preparation for the livestock and poultry of potent antistress function, another object of the present invention is to provide these livestock and poultry preparation method of antiviral B B-complex premixed feed preparation and specifically application.
Main Ingredients and Appearance L-AA of the present invention, can reduce body capillary permeability, can reduce the secretion of glucocorticoid, avoid because of its secretion excessive concentration produce immunosupress, strengthen body to high temperature, cold etc. stress adaptive faculty.Have stronger reproducibility, protective enzyme system, participates in the synthetic of dopamine norepinephrine, and enhancing antibody generates and strengthens leukocytic phagocytic activity, suppresses copying of viral DNA and RNA, and induction body produces interferon, thus enhanced machine body immunity function.Another compatibility composition DL-ɑ-tocopherol acetate of the present invention is important antioxidant, and main Cell protection film and Subcellular membrane are avoided Peroxidative damage, can not only strengthen humoral immune reaction, and can improve the function of cellular immune function and neutrophil.L-AA itself is not possess lipotropism matter oxidation, but under the condition existing at DL-ɑ-tocopherol acetate, can there is higher lipotropism matter oxidation, and L-AA can reduce DL-ɑ-tocopherol acetate free radical, recover the antioxidation of DL-ɑ-tocopherol acetate.Another composition taurine is a kind of amino acid with extensive physiologically active; there is protection lymphocyte and can promote its propagation; produce the effect of antibody; also can promote macrophage to produce interleukins, suppress the generation of free radical, the activity of protection antioxidase (SOD); reduce peroxidatic reaction of lipid; the integrality of Cell protection film, the secretory volume of increase trilute (T3), the anti-stress level of increase body.Therefore DL-ɑ-tocopherol acetate, L-AA and taurine compatibility can be worked in coordination with and be improved antioxidation; prevent or reduce protein oxidation, lipid peroxidation and various stress reaction; eliminate the free radical that the effect of body endoperoxides produces, there is very strong resisting and stress, improve immunization.
Polysaccharide composition FOS in the present invention is as immunologic adjuvant and antigen is participated in Cellular Immunity directly and humoral immunity regulates, promote hepatic secretion glycoprotein, cause immune response in conjunction with bacterium, PHA specific binding with pathogen surface, slowing down antigen absorbs, stimulate body immune system, improve the immune response ability of animal.Saccharicter-penin has Promote immunity allelotaxis, improve Immune Organs Index and Amount of Mast Cells, increase the activity of macrophage, lymphocyte, interleukins, Promote immunity transformation, maturation, improve antibody horizontal, regulate the content of CAMP/CGMP and the generation of complement, increase the effect such as secretory volume of trilute (T3), there is the effect of calmness, pain relieving, antipyretic, antibechic and anti-inflammatory; Papillary can regulate organismic internal environment balance, reduce body to stress sensitiveness, coordinate immunoregulation effect, can trivial solution except the immunosupress that stress produce, improve the anti-stress ability of animal.
Chinese medicinal ingredients Radix Codonopsis in the present invention, Radix Astragali invigorating qi for consolidating superficies, air making-up and spleen enlivening is monarch drug in a prescription altogether, and honeysuckle, clearing heat and detoxicating, the cool blood relieve sore throat of Radix Isatidis, the loose heresy of thin heat are ministerial drug altogether, barrenwort kidney-replenishing, strengthening the bones and muscles, wines used as antirheumatic, is adjutant, Radix Glycyrrhizae benefit gas and in, coordinate all medicines, for making medicine, all medicines share, and play altogether to mend and loose doublely execute, clearing heat and detoxicating, the beneficial gas of righting, consolidate a liter positive effect, there is the excitatory state of adjusting livestock and poultry nervous centralis, reduce sympathoadrenal nervous excitation, promote central immune organ (thymus gland, bursa of Fabricius etc.) and peripheral immune organ (spleen, lymph node etc.) growth, increase total white blood cells and phagocytic function, strengthen the activate the phagocytic capacity of macrophage, promote T cell proliferation, inducement interferon IFN-γ, improve T lymphocyte quantity, promote lymphocytic conversion, strengthen cytophagous function, improve local blood circulation, and there is Promote immunity underactivity, amphicheirality's regulating action that Immunosuppression function is too high.There is very strong resisting and stress, improve immunologic function.
The present invention is not the simple drug effect stack of vitamin, polysaccharide, amino acid, Chinese medicinal ingredients, but the cooperative compensating that the interaction of these compositions produces afterwards, bidirectional modulation, Yin Yang balancing, multipath, multi-faceted synergy.Can play obvious Promote immunity allelotaxis, induction body produces rapidly interferon, improves rapidly livestock and poultry body non-specific immune function and reaches antivirus action, have simultaneously antipyretic, analgesia, anti-inflammatory, anti-stress, the multiple action such as growth promotion.
Concrete technical scheme of the present invention is: antiviral B B-complex premixed feed preparation for a kind of livestock and poultry, is made up of the component of following weight portion: vitamin: 25～28 parts; Amino acid: 10～14 parts, polysaccharide: 56～44.5 parts, Chinese medical extract: 8-12 part, anticaking agent: 1-1.5 part; Wherein, described Chinese medical extract is the concentrated extract of Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae, the weight ratio of described Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, licorice piece is: 9～11:16～14:28～32:, 32～28:9～11:6～4.
Preferably, above-mentioned livestock and poultry are made up of the component of following weight portion with antiviral B B-complex premixed feed preparation: vitamin: 27～28 parts; Amino acid: 13～14 parts, polysaccharide: 48～44.8 parts, Chinese medical extract: 11～12 parts, anticaking agent: 1～1.2 part; Wherein, described Chinese medical extract is the concentrated extract of Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae, and the weight ratio of described Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae is: 9.5～10.5:14.5～15.5:29～31:29～31:9.5～10.5:4.8～5.2.
Above-mentioned livestock and poultry, with in antiviral B B-complex premixed feed preparation, described Chinese medical extract obtains by following concentration and extraction process:
Step 1: take Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae by above-mentioned weight ratio;
Step 2: the honeysuckle taking in step 1 is cleaned, add in percolate pot, adding concentration is that 70% ethanolic solution is to soaking full medicinal material, soak 12 hours, make solvent by percolation with 70% ethanol and carry out diacolation with the speed of 100ml per minute, diacolation is thin out to liquid color, drains the honeysuckle dregs of a decoction, collect filtrate and reclaim ethanol through decompression distillation, obtain honeysuckle concentrate;
Step 3: the Radix Codonopsis taking in step 1, the Radix Astragali, Radix Isatidis, barrenwort, licorice piece are cleaned and be placed in extractor, add the honeysuckle dregs of a decoction of step 2 gained, add water, the weight of the water adding in step 3 is each Chinese medicine gross weight of taking in step 1 3～5 times, boil; 80～85 DEG C of constant temperature decoct 1～1.5 hour, then heating boils and become 1/8～1/12 of former amount of water to the weight of liquid in 30 minutes, separate upper strata liquid and solid medicine slag blanket;
Step 4: the solid medicine slag blanket in step 3 is added again to the water that is equivalent to 2～3 times of solid medicine slag blanket weight, boil; 80～85 DEG C of constant temperature decoct 1 hour, then heating boil 30 minutes to liquid for 1/8～1/12 of institute's amount of water in step 4, leach upper strata liquid;
Step 5: step 2 is obtained to the upper strata liquid that upper strata liquid that honeysuckle concentrate, step 3 obtain and step 4 obtain and mix, put into concentration pan and concentrate, being concentrated into density is 1.38～1.40g/cm
3when (70 DEG C), spray dry, obtain the Chinese medical extract of soluble chocolate brown powder shape.
Above-mentioned livestock and poultry with in antiviral B B-complex premixed feed preparation, the weight of described Chinese medical extract be described Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae gross weight 1/10～1/15.
Preferably, the weight of described Chinese medical extract be described Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae gross weight 1/12～1/13.
Above-mentioned livestock and poultry with in antiviral B B-complex premixed feed preparation, described vitamin comprises L-AA, DL-ɑ-tocopherol acetate, niacinamide, VBT, the weight portion of described L-AA, DL-ɑ-tocopherol acetate, niacinamide, VBT is respectively: 8～12 parts, 0.8～1.2 part, 12～8 parts, 4.2～6.8 parts.
Preferably, the weight portion of described L-AA, DL-ɑ-tocopherol acetate, niacinamide, VBT is respectively: 9～11 parts, and 1.0～1.1 parts, 11～9 parts, 5～6 parts.
Above-mentioned livestock and poultry, with in antiviral B B-complex premixed feed preparation, described amino acid comprises taurine and silkworm compound amino acid, and the weight portion of described taurine and silkworm compound amino acid is respectively: 9～11 parts: 1～3 part.
Preferably, the weight portion of described taurine and silkworm compound amino acid is respectively: 9.5～10.5 parts: 1.5～2 parts.
Above-mentioned livestock and poultry, with in antiviral B B-complex premixed feed preparation, described polysaccharide comprises FOS and saccharicter-penin, and described FOS and the weight portion of saccharicter-penin are respectively: 52～36.5 parts, and 4～8 parts.
Preferably, described FOS and the weight portion of saccharicter-penin are respectively: 50～38 parts, and 5～7 parts.
The present invention also provides the preparation method of the above-mentioned antiviral B B-complex premixed feed preparation of livestock and poultry, and it specifically comprises the steps:
Step 1: take concentration by above-mentioned weight portion and be not less than 50%DL-ɑ-tocopherol acetate, silkworm compound amino acid, saccharicter-penin, VBT; And take the FOS equating with the gross weight of DL-ɑ-tocopherol acetate, silkworm compound amino acid, saccharicter-penin, VBT, and after premixed, cross 40 order stainless steel sifts, for subsequent use;
Step 2: the FOS that takes L-AA, niacinamide, taurine, Chinese medical extract, anticaking agent and remaining weight portion by above-mentioned weight portion, mixture after the premixed obtaining with step 1 is put into three-dimensional mixer, mix 15-20 minute, obtain taupe, color uniformity, without conglomeration, without the even soluble powder of color spot;
Step 3: step 2 gained mixture is carried out to the detections such as moisture content, granularity, discriminating, content on request, carry out on request packing after qualified, sealing, vanning, warehouse entry.
Examination criteria:
1. sanitary index: should meet GB13078 requirement, wherein total arsenic (in As)≤10mg/kg; Plumbous (in Pb)≤30mg/kg, fluorine (in F)≤1000mg/kg;
2. moisture content≤10% (GB/T6435);
3. granularity: be all that 1.19mm analyzes sieve by aperture, aperture is that 0.59mm analysis sieve oversize must not be greater than 10%.(GB/T5917.1)；
4. differentiate: (1) gets this product 0.2g, after the 10ml that adds water dissolves, the infrared Absorption collection of illustrative plates of this product should be consistent with the collection of illustrative plates (spectra collection 450 figure) of L-AA contrast;
(2) in the chromatogram recording under DL-ɑ-tocopherol acetate assay item, the retention time at test sample peak should with the retention time consistent (GB/T17812) at DL-ɑ-tocopherol acetate reference substance peak.
5. assay: L-AA >=80g/kg (GB/T17816), DL-ɑ-tocopherol acetate >=4g/kg (GB/T17812).
In preparation method above-mentioned livestock and poultry with antiviral B B-complex premixed feed preparation, described Chinese medical extract obtains by following concentration and extraction process:
Step 1: take Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae by above-mentioned weight ratio;
Step 2: the honeysuckle taking in step 1 is cleaned, add in percolate pot, adding concentration is that 70% ethanolic solution is to soaking full medicinal material, soak 12 hours, make solvent by percolation with 70% ethanol and carry out diacolation with the speed of 100ml per minute, diacolation is thin out to liquid color, drains the honeysuckle dregs of a decoction, collect filtrate and reclaim ethanol through decompression distillation, obtain honeysuckle concentrate;
Step 3: the Radix Codonopsis taking in step 1, the Radix Astragali, Radix Isatidis, barrenwort, licorice piece are cleaned and be placed in extractor, add the honeysuckle dregs of a decoction of step 2 gained, add water, the weight of the water adding in step 3 is each Chinese medicine gross weight of taking in step 1 3～5 times, boil; 80～85 DEG C of constant temperature decoct 1～1.5 hour, then heating boils and become 1/8～1/12 of former amount of water to the weight of liquid in 30 minutes, separate upper strata liquid and solid medicine slag blanket;
Step 4: the solid medicine slag blanket in step 3 is added again to the water that is equivalent to 2～3 times of solid medicine slag blanket weight, boil; 80～85 DEG C of constant temperature decoct 1 hour, then heating boil 30 minutes to liquid for 1/8～1/12 of institute's amount of water in step 4, leach upper strata liquid;
Step 5: step 2 is obtained to the upper strata liquid that upper strata liquid that honeysuckle concentrate, step 3 obtain and step 4 obtain and mix, put into concentration pan and concentrate, being concentrated into density is 1.38～1.40g/cm
3when (70 DEG C), spray dry, obtain the Chinese medical extract of soluble chocolate brown powder shape.
In preparation method above-mentioned livestock and poultry with antiviral B B-complex premixed feed preparation, the weight of described Chinese medical extract be described Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae gross weight 1/10～1/15.
Preferably, the weight of described Chinese medical extract be described Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae gross weight 1/12～1/13.
The present invention also provides above-mentioned livestock and poultry application in livestock and poultry cultivation with antiviral B B-complex premixed feed preparation, described livestock and poultry are added in the drinking water of livestock and poultry or are added in the daily ration of livestock and poultry with antiviral B B-complex premixed feed preparation, described livestock and poultry by the ratio of the drinking water of antiviral B B-complex premixed feed preparation and livestock and poultry are: the drinking water of the livestock and poultry of 2000L adds the antiviral B B-complex premixed feed preparation for livestock and poultry described in 1kg; Described livestock and poultry by the ratio of the daily ration of antiviral B B-complex premixed feed preparation and livestock and poultry are: in the daily ration of the livestock and poultry of 1000kg, add the antiviral B B-complex premixed feed preparation for livestock and poultry described in 1kg.
The present invention is by L-AA, DL-ɑ-tocopherol acetate, niacinamide, VBT, taurine, compound amino acid, FOS, saccharicter-penin, and by Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, the compositions such as the concentrated active ingredient of the Chinese herbal medicines such as Radix Glycyrrhizae, by suppressing copying of virus, promote fowl poultry immune allelotaxis, regulate active immune function, participate in the immune response of body, strengthen the immunity of body, induction body produces rapidly interferon, there is rapid raising livestock and poultry body non-specific immune function, improve livestock and poultry resistance against diseases, potent resisting stress.
The present invention is in the antiviral while, has antipyretic, anti-inflammatory concurrently, anti-ly stress wait multiple action, and the infection that virus is caused has multiple action, can shorten the time of heating, the diffusion controlling inflammation, promote the absorption etc. of inflammation, i.e. multipath, multi-faceted working; And can also enhanced machine body immunity function, stop cell entry cell tissue, toxic and side effect is less, and virus is difficult to it to develop immunity to drugs, and makes the present invention have obvious advantage aspect control livestock and poultry virus infectious diseases, and clinical prospect of the application is wide.
Detailed description of the invention
Below in conjunction with detailed description of the invention, technical scheme of the present invention is described in further detail, but does not form any limitation of the invention.
Embodiment 1
1, prepare Chinese medical extract.
Step 1.1: take Radix Codonopsis 10kg, honeysuckle 15kg, Radix Astragali 30kg, Radix Isatidis 30kg, barrenwort 10kg, Radix Glycyrrhizae 5kg;
Step 1.2: the honeysuckle taking is cleaned, add in percolate pot, adding concentration is that 70% ethanolic solution is to soaking full medicinal material, soak 12 hours, make solvent by percolation with 70% ethanol and carry out diacolation with the speed of 100ml per minute, diacolation is thin out to liquid color, drains the honeysuckle dregs of a decoction, collect filtrate and reclaim ethanol through decompression distillation, obtain honeysuckle concentrate;
Step 1.3: the Radix Codonopsis taking, the Radix Astragali, Radix Isatidis, barrenwort, licorice piece are cleaned and be placed in extractor, add the honeysuckle dregs of a decoction of step 1.2 gained, add water 400kg, boil; 80～85 DEG C of constant temperature decoct 1.5 hours, then heating is boiled the 40 ± 1kg that becomes former amount of water for 30 minutes to the weight of liquid, separation upper strata liquid and solid medicine slag blanket;
Step 1.4: the solid medicine slag blanket in step 1.3 is added again to the water that is equivalent to 2.5 times of solid medicine slag blanket weight, boil; 80～85 DEG C of constant temperature decoct 1 hour, then heating boil 30 minutes to liquid for 1/10 of institute's amount of water in step 1.4, leach upper strata liquid;
Step 1.5: step 1.2 is obtained to the upper strata liquid that upper strata liquid that honeysuckle concentrate, step 1.3 obtain and step 1.4 obtain and mix, put into concentration pan and concentrate, thickening temperature is 100 ± 5 DEG C, and being concentrated into density is 1.38～1.40g/cm
3when (70 DEG C), spray dry, obtain the Chinese medical extract of soluble chocolate brown powder shape, weight is 8.5 ± 1kg.
2, prepare antiviral B B-complex premixed feed preparation for livestock and poultry.
Step 2.1: take concentration and be not less than 50%DL-ɑ-tocopherol acetate 1kg, silkworm compound amino acid 2kg, saccharicter-penin 5kg, VBT 5kg and FOS 13kg, after premixed, cross 40 order stainless steel sifts, for subsequent use;
Step 2.2: take L-AA 10kg, niacinamide 10kg, taurine 10kg, Chinese medical extract 10kg, anticaking agent 1kg and FOS 33kg, mixture after the premixed obtaining with step 2.1 is put into three-dimensional mixer, mix 18 minutes, obtain taupe, color uniformity, without conglomeration, without the even soluble powder 100kg of color spot;
Step 3.3: step 2 gained mixture is carried out to the detections such as moisture content, granularity, discriminating, content on request, obtain sample 1 after qualified.
Examination criteria:
1. sanitary index: should meet GB 13078 requirements, wherein total arsenic (in As)≤10mg/kg; Plumbous (in Pb)≤30mg/kg, fluorine (in F)≤1000mg/kg;
2. moisture content≤10% (GB/T6435);
3. granularity: be all that 1.19mm analyzes sieve by aperture, aperture is that 0.59mm analysis sieve oversize must not be greater than 10%.(GB/T5917.1)；
4. differentiate: (1) gets this product 0.2g, after the 10ml that adds water dissolves, the infrared Absorption collection of illustrative plates of this product should be consistent with the collection of illustrative plates (spectra collection 450 figure) of L-AA contrast;
(2), in the chromatogram recording under DL-ɑ-tocopherol acetate assay item, the retention time at test sample peak should consistent with the retention time at DL-ɑ-tocopherol acetate reference substance peak (GB/T 17812).
5. assay: L-AA >=80g/kg (GB/T 17816), DL-ɑ-tocopherol acetate >=4g/kg (GB/T17812).
Embodiment 2:
Identical with formula and the preparation technology of embodiment 1, different places are, the weight of the each taste Chinese medicine taking is: take Radix Codonopsis 9.5kg, honeysuckle 15.5kg, Radix Astragali 29kg, Radix Isatidis 31kg, barrenwort 10.3kg, Radix Glycyrrhizae 4.7kg.
Embodiment 3:
Identical with formula and the preparation technology of embodiment 1, different places are, the weight of the each taste Chinese medicine taking is: take Radix Codonopsis 10.5kg, honeysuckle 14.5kg, Radix Astragali 31kg, Radix Isatidis 29kg, barrenwort 9.7kg, Radix Glycyrrhizae 5.3kg.
Embodiment 4:
Identical with formula and the preparation technology of embodiment 1; different places are; vitamin and amino acid whose content change to some extent; its concrete weight is: concentration is not less than 50%DL-ɑ-tocopherol acetate 1.5kg; silkworm compound amino acid 2.5kg, VBT 5.5kg, L-AA 11kg; niacinamide 11kg, taurine 11kg.
Embodiment 5:
Identical with formula and the preparation technology of embodiment 1, different places are, the content of polysaccharide changes to some extent, and it is specially: the saccharicter-penin in step 2.1 is 4kg, and FOS is 12kg, and the FOS adding in step 2.2 is 31.5kg.
Comparative example 1
Preparation contrast sample 1.
Step 3.1: take concentration and be not less than 50%DL-ɑ-tocopherol acetate 1kg, silkworm compound amino acid 2kg, saccharicter-penin 5kg, VBT 5kg and FOS 13kg, after premixed, cross 40 order stainless steel sifts, for subsequent use;
Step 3.2: take L-AA 10kg, niacinamide 10kg, taurine 10kg, anticaking agent 1kg and FOS 43kg; mixture after the premixed obtaining with step 3.1 is put into three-dimensional mixer; mix 18 minutes; obtain 100kg canescence; color uniformity; without conglomeration, be contrast sample 1 without the even soluble powder of color spot.
Comparative example 2
Preparation contrast sample 2.
Step 4.1: take concentration and be not less than 50%DL-ɑ-tocopherol acetate powder 1kg, silkworm compound amino acid 2kg, VBT 5kg, after premixed, cross 40 order stainless steel sifts, for subsequent use;
Step 4.2: take L-AA 10kg, niacinamide 10kg, taurine 10kg, Chinese medical extract 61kg; anticaking agent 1kg; mixture after the premixed obtaining with step 4.1 is put into three-dimensional mixer; mix 18 minutes; obtain 100kg taupe; color uniformity, without conglomeration, is contrast sample 2 without the even soluble powder of color spot.
Wherein, the preparation technology of Chinese medical extract and formula are identical with embodiment 1.
Animal feeding embodiment 1
Sample 1, contrast sample 1 and the impact of contrast sample 2 on meat chicken production performance.
1. materials and methods
1.1 for examination animal and grouping
The unified raising after one week of the fast large yellow-feather broiler of Wen Shi of 1 age in days, randomly draws 600, is divided into 4 groups, every group of 3 repetitions, and 50 of each repetitions, point experiment I group, experiment II group, experiment III group, blank group, and take initial body weight; Experiment I group is added 0.5 ‰ embodiment 1 samples 1 by drinking-water, and being used in conjunction every other week 3 days is a course for the treatment of; Experiment II group is added 0.5 ‰ comparative examples 1 by drinking-water and is contrasted sample 1, and being used in conjunction every other week 3 days is a course for the treatment of; Experiment III group is added 0.5 ‰ comparative examples 2 by drinking-water and is contrasted sample 2, and being used in conjunction every other week 3 days is a course for the treatment of; Blank group is only added basal diet pellet and daily drinking water.Experimental group and blank group all adopt and raise in cages, free choice feeding drinking-water, and four groups, basal diet pellet is identical, and concrete formula is corn 55.3%, dregs of beans 36%, calcium monohydrogen phosphate 1.8%, stone flour 1%, fat oil 1.4%, fish meal 2.5%, premix 2%.Adopt conventional feeding and management, record broiler chicken daily feed intake, dead quantity, regularly carry out immunity and cleaning hen house, test breeding cycle is 35 days.
2. growth performance is measured
Healthy chicken is weighed after 3h on an empty stomach taking group as unit respectively at 14,21,28,35,42 ages in days, on an empty stomach, freely drink water, accurately weigh and record day feed quantity, residue material amount, loss material amount and dead quantity, calculate each stage average daily gain, average daily ingestion amount, feedstuff-meat ratio and survival rate.
The initial average weight of 7 age in days: only, only, only, blank group 101.4g/ only for experiment III group 100.8g/ for experiment II group 101.2g/ for experiment I group 101.5g/.
2.1 results and data
Table one:
Result of the test shows:
Feed sample 1, contrast sample 1 and contrast sample 2 all can reduce the feedstuff-meat ratio of each mensuration age in days, and 1 group, the sample of the present invention of feeding is minimum at each mensuration age in days feedstuff-meat ratio, and average daily gain, survival rate are also the most obvious.Although effect might not be embodied in average feed intake or average daily gain, it is the highest necessarily having embodied interpolation sample 1 feed conversion rate of the present invention.Although sample 1 and contrast sample 2 effects are the most approaching, the cost of material of contrast sample 2 divide than sample 1 Senior Three two.Therefore can infer, livestock and poultry of the present invention not only can significantly reduce feedstuff-meat ratio with antiviral B B-complex premixed feed preparation, reduce use cost, can also significantly improve broiler chicken resistance against diseases and survival rate.
3. the mensuration of immunologic function
The main Immune Organs Index of measuring: Immune Organs Index (mg/g)=immune organ weight/live body weight.
From each group of healthy chicken, randomly draw 5 chickens respectively at 14 ages in days, 28 ages in days and 42 ages in days, after 12h, weigh respectively on an empty stomach, on an empty stomach, freely drink water, after accurately weighing, heart is squeezed into air method and is put to death chicken, dissect, win spleen and the bursa of farbricius, reject the rear fresh weight that claims of fat, calculate spleen and bursa of farbricius index.
3.1 results and data
Table two:
Result of the test shows:
Be not difficult to find out that by table two index and spleen index of each experimental group and bursa of farbricius index are all higher than blank group, 1 group, the sample of the present invention of wherein feeding is the peak of each mensuration age in days, and also very remarkable with the difference of other test group.Therefore, livestock and poultry of the present invention have promotion fowl poultry immune allelotaxis clearly with antiviral B B-complex premixed feed preparation, regulate active immune function, strengthen the immunity of body, improve the effect of livestock and poultry resistance against diseases, and use cost are low.
Animal feeding embodiment 2
Sample 1 and contrast sample 1 and contrast sample 2 are to strengthening the comparative test of piglet immunological ability.
1, materials and methods
(1) material
Get the contrast sample 2 of the sample 1 of above-described embodiment 1 and the contrast sample 1 of comparative example 1 and comparative example 2 as the test material of the present embodiment.
(2) conceptual design
Subjects is that source is consistent, same parity, the farrowing time is close, litter size is identical, and sex ratio is close, weight of weaning litter, the Du great Chang ternary weanling pig that body weight is close, be divided into and test I group, experiment II group, test totally 4 groups of III group and blank groups by paired experiment principle, every group of 3 repetitions, 20 of each repetitions, totally 240.Experiment I initial counterpoise of group (10.16 ± 1.15) kg, experiment II initial counterpoise of group (10.18 ± 1.21) kg, experiment III initial counterpoise of group (10.22 ± 1.18) kg, initial counterpoise of blank group (10.23 ± 1.25) kg, the experiment I group sample 1 of feeding, feeds 3 days week about; Experiment II group is fed and is contrasted sample 1, feeds week about 3 days; Experiment III group is fed and is contrasted sample 2, feeds week about 3 days; Blank group is not additionally added any medicated premix.1kg sample 1 mix fodder 1000kg, 1kg contrast sample 1 mix fodder 1000kg, 1kg contrast sample 2 mix fodder 1000kg, allow the piglet free choice feeding, the cycle of feeding be 50 days.Experimental group and the blank group particulate material of all throwing something and feeding four times every day, regularly cleans pig house during this time, and vaccine program vaccinate.The concrete formula of particulate material is corn 54%, fine rice bran 5.94%, high-quality fish meal 5%, dregs of beans 31%, calcium monohydrogen phosphate 1.2%, stone flour 0.7%, salt 0.16%, premix 2.0%.
In 50 days, record the diarrhoea frequency of control group and experimental group.
2, result and data
Table three:
| ? | Experiment I group | Experiment II group | Experiment III group | Blank group |
| Initial average weight kg | 10.16 | 10.18 | 10.22 | 10.23 |
| Average weight kg after 50 days | 43.16 | 40.78 | 42.12 | 37.38 |
| Incidence of Diarrhea | 1.67％ | 8.33％ | 3.33％ | 36.67％ |
| The death rate | 0％ | 1.67％ | 0％ | 11.67％ |
| Daily gain g/ days | 660 | 612 | 638 | 543 |
Result of the test shows:
Find out that by table three Incidence of Diarrhea of each experimental group and the death rate are all starkly lower than blank group, daily gain is also apparently higher than blank group; The 1 group of effect of sample of the present invention of wherein feeding is the most obvious, and also very remarkable with the difference of other experimental group.At experimental session, there is the temperature of one week to continue to exceed 36 DEG C, every physical signs such as the experimental group pig state of mind, appetite, sleep all change not quite, especially with feed 1 group, sample of the present invention the most steadily, normal, and blank group pig obviously occurs that the high temperature such as yellow short red, the argol difficult defecation of agitation, drowsiness, do not feel like eating, urine stress phenomenon.Therefore, livestock and poultry of the present invention have promotion fowl poultry immune allelotaxis clearly with antiviral B B-complex premixed feed preparation, strengthen the immunity of body, not only significantly improve the growth performance of piglet, can also significantly reduce the incidence of intestine of young pigs disease and improve resistance against diseases, potent anti-stress, and use cost is low, cost performance is the highest.
Above-described is only preferred embodiment of the present invention, all any amendments of doing within the scope of the spirit and principles in the present invention, is equal to and replaces and improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. an antiviral B B-complex premixed feed preparation for livestock and poultry, is characterized in that, is made up of: vitamin: 25～28 parts the component of following weight portion; Amino acid: 10～14 parts, polysaccharide: 56～44.5 parts, Chinese medical extract: 8～12 parts, anticaking agent: 1～1.5 part; Wherein, described Chinese medical extract is the concentrated extract of Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae, the weight ratio of described Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, licorice piece is: 9～11:16～14:28～32:, 32～28:9～11:6～4.
2. antiviral B B-complex premixed feed preparation for livestock and poultry according to claim 1, is characterized in that, described Chinese medical extract obtains by following concentration and extraction process:
Step 1: take Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae by weight ratio claimed in claim 1;
Step 2: the honeysuckle taking in step 1 is cleaned, add in percolate pot, adding concentration is that 70% ethanolic solution is to soaking full medicinal material, soak 12 hours, make solvent by percolation with 70% ethanol and carry out diacolation with the speed of 100ml per minute, diacolation is thin out to liquid color, drains the honeysuckle dregs of a decoction, collect filtrate and reclaim ethanol through decompression distillation, obtain honeysuckle concentrate;
Step 3: the Radix Codonopsis taking in step 1, the Radix Astragali, Radix Isatidis, barrenwort, licorice piece are cleaned and be placed in extractor, add the honeysuckle dregs of a decoction of step 2 gained, add water, the weight of the water adding in step 3 is each Chinese medicine gross weight of taking in step 1 3～5 times, boil; 80～85 DEG C of constant temperature decoct 1～1.5 hour, then heating boils and become 1/8～1/12 of former amount of water to the weight of liquid in 30 minutes, separate upper strata liquid and solid medicine slag blanket;
Step 4: the solid medicine slag blanket in step 3 is added again to the water that is equivalent to 2～3 times of solid medicine slag blanket weight, boil; 80～85 DEG C of constant temperature decoct 1 hour, then heating boil 30 minutes to liquid for 1/8～1/12 of institute's amount of water in step 4, leach upper strata liquid;
Step 5: step 2 is obtained to the upper strata liquid that upper strata liquid that honeysuckle concentrate, step 3 obtain and step 4 obtain and mix, put into concentration pan and concentrate, being concentrated into density under the condition of 70 DEG C is 1.38～1.40g/cm
3time, spray dry, obtain the Chinese medical extract of soluble chocolate brown powder shape.
3. antiviral B B-complex premixed feed preparation for livestock and poultry according to claim 2, it is characterized in that, the weight of described Chinese medical extract be described Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, licorice piece gross weight 1/10～1/15.
4. according to the arbitrary described antiviral B B-complex premixed feed preparation for livestock and poultry of claim 1～3, it is characterized in that, described vitamin comprises L-AA, DL-ɑ-tocopherol acetate, niacinamide, VBT, the weight portion of described L-AA, DL-ɑ-tocopherol acetate, niacinamide, VBT is respectively: 8～12 parts, 0.8～1.2 part, 12～8 parts, 4.2～6.8 parts.
5. antiviral B B-complex premixed feed preparation for livestock and poultry according to claim 4; it is characterized in that; described amino acid comprises taurine and silkworm compound amino acid, and the weight portion of described taurine and silkworm compound amino acid is respectively: 9～11 parts, and 1～3 part.
6. antiviral B B-complex premixed feed preparation for livestock and poultry according to claim 5, is characterized in that, described polysaccharide comprises FOS and saccharicter-penin, and described FOS and the weight portion of saccharicter-penin are respectively: 52～36.5 parts, and 4～8 parts.
7. a preparation method for antiviral B B-complex premixed feed preparation for livestock and poultry as claimed in claim 6, is characterized in that, comprises the following steps:
Step 1: take concentration by weight portion claimed in claim 6 and be not less than 50%DL-ɑ-tocopherol acetate, silkworm compound amino acid, saccharicter-penin, VBT; And take the FOS equating with the gross weight of DL-ɑ-tocopherol acetate, silkworm compound amino acid, saccharicter-penin, VBT, and after premixed, cross 40 order stainless steel sifts, for subsequent use;
Step 2: the FOS that takes L-AA, niacinamide, taurine, Chinese medical extract, anticaking agent and remaining weight portion by weight portion claimed in claim 6, together with mixture after the premixed obtaining with step 1, put into three-dimensional mixer, mix 15～20 minutes, obtain taupe, color uniformity, without conglomeration, without the even soluble powder of color spot;
Step 3: step 2 gained mixture is carried out to the detections such as moisture content, granularity, discriminating, content on request, carry out on request packing after qualified, sealing, vanning, warehouse entry.
8. the preparation method of antiviral B B-complex premixed feed preparation for livestock and poultry according to claim 7, is characterized in that: described Chinese medical extract obtains by following concentration and extraction process:
Step 1: take Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae by weight ratio claimed in claim 7;
Step 2: the honeysuckle taking in step 1 is cleaned, add in percolate pot, adding concentration is that 70% ethanolic solution is to soaking full medicinal material, soak 12 hours, make solvent by percolation with 70% ethanol and carry out diacolation with the speed of 100ml per minute, diacolation is thin out to liquid color, drains the honeysuckle dregs of a decoction, collect filtrate and reclaim ethanol through decompression distillation, obtain honeysuckle concentrate;
Step 3: the Radix Codonopsis taking in step 1, the Radix Astragali, Radix Isatidis, barrenwort, licorice piece are cleaned and be placed in extractor, add the honeysuckle dregs of a decoction of step 2 gained, add water, the weight of the water adding in step 3 is each Chinese medicine gross weight of taking in step 1 3～5 times, boil; 80～85 DEG C of constant temperature decoct 1～1.5 hour, then heating boils and become 1/8～1/12 of former amount of water to the weight of liquid in 30 minutes, separate upper strata liquid and solid medicine slag blanket;
Step 4: the solid medicine slag blanket in step 3 is added again to the water that is equivalent to 2～3 times of solid medicine slag blanket weight, boil; 80～85 DEG C of constant temperature decoct 1 hour, then heating boil 30 minutes to liquid for 1/8～1/12 of institute's amount of water in step 4, leach upper strata liquid;
Step 5: step 2 is obtained to the upper strata liquid that upper strata liquid that honeysuckle concentrate, step 3 obtain and step 4 obtain and mix, put into concentration pan and concentrate, being concentrated into density is 1.38～1.40g/cm
3when (70 DEG C), spray dry, obtain the Chinese medical extract of soluble chocolate brown powder shape.
9. the preparation method of antiviral B B-complex premixed feed preparation for livestock and poultry according to claim 7, is characterized in that: the weight of described Chinese medical extract be described Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, licorice piece gross weight 1/10～1/15.
10. livestock and poultry as claimed in claim 1 application in livestock and poultry cultivation with antiviral B B-complex premixed feed preparation, it is characterized in that: described livestock and poultry are added in the drinking water of livestock and poultry or are added in the daily ration of livestock and poultry with antiviral B B-complex premixed feed preparation, described livestock and poultry by the ratio of the drinking water of antiviral B B-complex premixed feed preparation and livestock and poultry are: the drinking water of the livestock and poultry of 2000L adds the antiviral B B-complex premixed feed preparation for livestock and poultry described in 1kg; Described livestock and poultry by the ratio of the daily ration of antiviral B B-complex premixed feed preparation and livestock and poultry are: in the daily ration of the livestock and poultry of 1000kg, add the antiviral B B-complex premixed feed preparation for livestock and poultry described in 1kg.
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104664068A (en) * | 2015-03-18 | 2015-06-03 | 广东迈科特生物科技有限公司 | Special multivitamin immunopolysaccharide microemulsion preparation for waterfowl and preparation method and application thereof |
| CN104705528A (en) * | 2015-03-31 | 2015-06-17 | 广州益牲宝动物药业有限公司 | Multivitamin fermented Chinese herbal medicine preparation special for breeding sows as well as preparation method and application thereof |
| CN105309825A (en) * | 2015-11-30 | 2016-02-10 | 山东绿都安特动物药业有限公司 | Feed additive capable of resisting heat stress and relieving oxidative stress injuries and used for broiler chickens |
| CN106578362A (en) * | 2015-10-17 | 2017-04-26 | 饶平东泽生物科技有限公司 | Feed additive formula |
| CN107348134A (en) * | 2016-05-09 | 2017-11-17 | 陆文雄 | A kind of feed appetizing additive |
| CN107668419A (en) * | 2017-11-22 | 2018-02-09 | 陈琼燕 | Feed of grass carp and preparation method thereof |
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| CN111789190A (en) * | 2020-07-31 | 2020-10-20 | 李志刚 | Traditional Chinese medicine feed additive for improving animal organism immunity, feed and preparation method |
| CN111972539A (en) * | 2020-08-19 | 2020-11-24 | 中兽医(汤阴)生物科技有限公司 | Additive for improving immunity of livestock and poultry organisms and preparation method thereof |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101756027A (en) * | 2008-12-11 | 2010-06-30 | 天津瑞贝特科技发展有限公司 | Antiviral growth promoting premix feed and preparation method thereof |
| CN102308910A (en) * | 2011-04-15 | 2012-01-11 | 广东养宝生物制药有限公司 | Livestock composite premix compound containing Chinese medicinal ingredients and packaging method thereof |
| CN102835567A (en) * | 2011-06-21 | 2012-12-26 | 天津佳瑞兴科技发展有限公司 | Traditional Chinese medicine-containing feed premix for preventing respiratory disease |
| CN102872272A (en) * | 2012-10-16 | 2013-01-16 | 青岛田瑞生态科技有限公司 | Poison-removing soup for chickens and manufacturing and using methods for poison-removing soup |
| CN102934744A (en) * | 2012-07-03 | 2013-02-20 | 山东绿都安特动物药业有限公司 | Regulating agent capable of resisting stress, promoting growth and improving metabolism for pigs |
| CN103120265A (en) * | 2013-02-27 | 2013-05-29 | 河南新正好生物工程有限公司 | Premix feed for increasing egg yield during laying hen egg-producing period |
| CN103181477A (en) * | 2011-12-27 | 2013-07-03 | 北京资源亚太动物药品有限公司 | Antiviral growth-promoting premix feed for pig and preparation method thereof |
-
2014
- 2014-06-18 CN CN201410272612.6A patent/CN104012807B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101756027A (en) * | 2008-12-11 | 2010-06-30 | 天津瑞贝特科技发展有限公司 | Antiviral growth promoting premix feed and preparation method thereof |
| CN102308910A (en) * | 2011-04-15 | 2012-01-11 | 广东养宝生物制药有限公司 | Livestock composite premix compound containing Chinese medicinal ingredients and packaging method thereof |
| CN102835567A (en) * | 2011-06-21 | 2012-12-26 | 天津佳瑞兴科技发展有限公司 | Traditional Chinese medicine-containing feed premix for preventing respiratory disease |
| CN103181477A (en) * | 2011-12-27 | 2013-07-03 | 北京资源亚太动物药品有限公司 | Antiviral growth-promoting premix feed for pig and preparation method thereof |
| CN102934744A (en) * | 2012-07-03 | 2013-02-20 | 山东绿都安特动物药业有限公司 | Regulating agent capable of resisting stress, promoting growth and improving metabolism for pigs |
| CN102872272A (en) * | 2012-10-16 | 2013-01-16 | 青岛田瑞生态科技有限公司 | Poison-removing soup for chickens and manufacturing and using methods for poison-removing soup |
| CN103120265A (en) * | 2013-02-27 | 2013-05-29 | 河南新正好生物工程有限公司 | Premix feed for increasing egg yield during laying hen egg-producing period |
Non-Patent Citations (2)
| Title |
|---|
| 刘建: "《兽药和饲料添加剂手册》", 31 August 2001, 上海科学技术文献出版社 * |
| 许哲 等: "金银花提取工艺研究", 《黑龙江医药》 * |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104664068A (en) * | 2015-03-18 | 2015-06-03 | 广东迈科特生物科技有限公司 | Special multivitamin immunopolysaccharide microemulsion preparation for waterfowl and preparation method and application thereof |
| CN104705528A (en) * | 2015-03-31 | 2015-06-17 | 广州益牲宝动物药业有限公司 | Multivitamin fermented Chinese herbal medicine preparation special for breeding sows as well as preparation method and application thereof |
| CN106578362A (en) * | 2015-10-17 | 2017-04-26 | 饶平东泽生物科技有限公司 | Feed additive formula |
| CN105309825A (en) * | 2015-11-30 | 2016-02-10 | 山东绿都安特动物药业有限公司 | Feed additive capable of resisting heat stress and relieving oxidative stress injuries and used for broiler chickens |
| CN107348134A (en) * | 2016-05-09 | 2017-11-17 | 陆文雄 | A kind of feed appetizing additive |
| CN107668417A (en) * | 2017-11-22 | 2018-02-09 | 陈琼燕 | Carp feed and preparation method thereof |
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| CN108208411B (en) * | 2018-03-01 | 2021-08-03 | 山东德州神牛药业有限公司 | Metabolism immunoregulation composite solution for livestock and poultry and preparation method thereof |
| CN110150469A (en) * | 2019-06-04 | 2019-08-23 | 上海同仁药业股份有限公司 | A kind of livestock and poultry premixed feed and its preparation and feeding method with antiviral efficacy |
| CN110506843A (en) * | 2019-08-13 | 2019-11-29 | 安徽快康生物科技有限公司 | It is a kind of for building up health, improving the feed addictive and feed of anti-stress ability |
| CN111789190A (en) * | 2020-07-31 | 2020-10-20 | 李志刚 | Traditional Chinese medicine feed additive for improving animal organism immunity, feed and preparation method |
| CN111972539A (en) * | 2020-08-19 | 2020-11-24 | 中兽医(汤阴)生物科技有限公司 | Additive for improving immunity of livestock and poultry organisms and preparation method thereof |
| CN116268196A (en) * | 2022-12-20 | 2023-06-23 | 山东鑫谷健康产业有限公司 | Plant source composite additive and application thereof |
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Effective date of registration: 20210713 Address after: Room 2105, No.2, Fangda Road, Huangpu District, Guangzhou, Guangdong 510500 Patentee after: GUANGDONG GINPIN ANIMAL NUTRITION Co.,Ltd. Address before: 510500 room 1308, building 2, No. 135, Xianlie East Road, Tianhe District, Guangzhou City, Guangdong Province Patentee before: GUANGDONG GINPIN ANIMAL NUTRITION Co.,Ltd. Patentee before: GUANGZHOU YOUVI BIOTECHNOLOGY Co.,Ltd. Patentee before: GUANGDONG GUOYAOTANG BIOTECHNOLOGY Co.,Ltd. |
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Denomination of invention: A antiviral compound vitamin premixed feed preparation and preparation method for livestock and poultry, and its application Effective date of registration: 20230911 Granted publication date: 20151230 Pledgee: Bank of China Limited Guangzhou Development Zone Branch Pledgor: GUANGDONG GINPIN ANIMAL NUTRITION CO.,LTD. Registration number: Y2023980056223 |