CN104705528A - Multivitamin fermented Chinese herbal medicine preparation special for breeding sows as well as preparation method and application thereof - Google Patents
Multivitamin fermented Chinese herbal medicine preparation special for breeding sows as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a multivitamin fermented Chinese herbal medicine preparation special for breeding sows. Per 1000 parts by weight of the multivitamin fermented Chinese herbal medicine preparation special for breeding sows comprise the following components in parts by weight: 64.5-101.1 parts of multivitamins, 5-10 parts of compound amino acids, 75-100 parts of polysaccharides, 819.6-725.8 parts of compound traditional Chinese medicine fermented fine powder, wherein per 1000 parts by weight of the compound traditional Chinese medicine fermented fine powder is obtained by fermenting the following traditional Chinese medicine raw materials with 5-10 parts of glucose: 100-120 parts of white atractylodes rhizome, 100-120 parts of folium artemisiae argyi, 50-70 parts of angelica sinensis, 35-60 parts of ligusticum wallichii, 80-100 parts of codonopsis pilosula, 100-70 parts of astragalus membranaceus, 100-80 parts of pericarpium citri reticulatae, 150-120 parts of rice sprout, 250-200 parts of pine needle meal and 30-50 parts of liquorice. The invention aims at providing a multivitamin fermented Chinese herbal medicine preparation special for breeding sows, which is capable of rapidly supplementing nutrition, increasing a pregnancy rate and a litter size, and improving anti-stress and anti-disease capacities; another purpose of the invention is to provide a preparation method and specific applications for the preparation.
Description
Technical field
The present invention relates to animal feed additive field, particularly a broad sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations, and its preparation method and application.
Background technology
On January 1st, 2014, livestock and poultry breeding scale pollution prevention ordinance is formally carried out, and pig-breeding industry becomes primary environmental transformation object.Due to 2014, annual live pig delivered price continued downturn for sale, 4-5 month is even lower than 5 yuan per jin, most of the time hovers between 6-7 unit, all lower than 6: 1 pig grain rate of exchange breakeven points, add rising steadily of the expenses such as feedstuff, artificial, epidemic prevention and control medicine and studio rent, approximately to lose money 150-300 unit from numerous autotrophy pork pig, greatly hit the cultivation of vast pig farmer and mended hurdle enthusiasm.Can continuous 10 months of numerous sow livestock on hand lower than the early warning value falling 5% in " alleviating live pig market price cyclic fluctuation regulation and control prediction scheme " on a year-on-year basis, about livestock on hand will only have forty-two million head in the end of the year.How to realize pig-breeding industry sustainable health development, walk out this quagmire of cultivation loss of capital, ensure the vegetable basket sufficient supplies of broad masses of the people, become live pig practitioner and relevant industries ruminate over and problem demanding prompt solution, and live pig control and prevention of disease and how to tap the latent power and improve sow production performance research and just seem particularly important.
In large scale of pig farm is produced; before weaned piglet, whether are the height of survival rate and health; the direct economic benefit affecting Swine Production person, and whether the height of piglet survival ratio depends on the health of sow reproductive phase, that is the reason of said " mother is carefully a brood of " among the people.General Large-scale pig farm sow annual farrowing pig 18-22 only at present; piglet is by being born to delivering survival rate 78-83% for sale; produce piglet 25-28 head every year well below developed country sows such as Denmark, the U.S., Canada, piglet is born to the feeding standard level of delivering survival rate 88-92% for sale.Therefore, how effective guarantee sow health status and tap the latent power and improve the most important thing that reproductive performance measure is Swine Production link.
And the most effective prevention and control measure the most conventional for deadly infectious disease multiple in sow breeding process is exactly vaccine injection at present, and the control of normal disease common in sow breeding process is also rested on depend on unduly antibiotic and abuse, even also fallen into and used antibiotic diseases prevention to urge long mistaken ideas, the immunologic function destroying cultivated animals that antibiotic long-term abuse is serious also produces drug resistance, because the general quality of China pig industry practitioner is lower and state supervision is not in place, the abuse of antibiotics phenomenon of the volume that transfinites, super kind ubiquity reached startling stage especially, uses forbidden drug event of common occurrence especially, in sow breeding process in order to voluminous piglet many in feed the violated testosterone propionate that adds, the hormonal components such as diethylstilbestrol, in feed, Amoxicillin is added in a large number for a long time in order to prevent disease, the antibiotic compositions such as cephalo-type, but often do not reach expected effect, play the reaction of trying to help the shoot grow by pulling it upward on the contrary, sow health index is more and more lower, farrowing quantity, birth weight, weanling weight, survival rate, the indexs such as healthy rate all do not reach cultivation standard-required, thus culture benefit is more and more lower even loses money, the serious healthy and sustainable development that have impact on China's pig industry.Along with the intensive large-scale development of China's aquaculture and the universal of healthy aquaculture industrial policy; the strict implement of China's the law of food safety and livestock and poultry breeding scale pollution prevention ordinance is implemented; green health, drug residue free, there is Nutrition and health function; the Application and Development of animal nutritious health product of substitute antibiotics can account for more and more consequence in animal-breeding process, be also the emphasis research topic of vast researcher.
Summary of the invention
The object of the present invention is to provide a kind of extra-nutrition fast, improve pregnancy rate and litter size, raising resisting stress and resistance against diseases; and having nourishing qi and blood, antiabortive, warming kidney and strengthening spleen, protection embryo nidation, nourishing the fetus of preventing miscarriage, the sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations that improves sow immunologic function of becoming pregnant, improve the effect of piglet survival ratio and strong young rate, another object of the present invention is the preparation method and the embody rule that provide this sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations.
Concrete technical scheme of the present invention is: a broad sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations, the sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations of every 1000 weight portions comprises following parts by weight of component: 64.5 ~ 101.1 parts of B B-complexes, 5 ~ 10 parts of compound amino acids, 75 ~ 110 parts of polysaccharide, 819.6 ~ 725.8 parts of part compound Chinese medicine fermentation fine powders, wherein, the compound Chinese medicine fermentation fine powder of every 1000 weight portions is passed through by following Chinese medicine material and 5 ~ 10 parts of glucose fermentations obtain: the bighead atractylodes rhizome 100 ~ 120 parts, tarragon 100 ~ 120 parts, Radix Angelicae Sinensis 50 ~ 70 parts, Ligusticum wallichii: 35 ~ 60 parts, Radix Codonopsis 80 ~ 100 parts, the Radix Astragali 100 ~ 70 parts, dried orange peel 100 ~ 80 parts, rice sprout 150 ~ 120 parts, pine needle meal 250 ~ 200 parts, 30 ~ 50 parts, Radix Glycyrrhizae.
Preferably, described B B-complex is 70.5 ~ 95.1 weight portions;
Preferably, described compound amino acid is 6 ~ 9 weight portions;
Preferably, described polysaccharide is 83 ~ 104 weight portions;
Preferably, the weight of described compound Chinese medicine fermentation fine powder is 735 ~ 805 weight portions, and the compound Chinese medicine fermentation fine powder of every 1000 weight portions is obtained by following Chinese medicine material warp and 5 ~ 10 parts of glucose everfermentations: the bighead atractylodes rhizome 105 ~ 115 parts, tarragon 105 ~ 115 parts, Radix Angelicae Sinensis 53 ~ 67 parts, Ligusticum wallichii: 40 ~ 55 parts, Radix Codonopsis 82 ~ 96 parts, the Radix Astragali 75 ~ 95 parts, dried orange peel 85 ~ 98 parts, rice sprout 125 ~ 145 parts, pine needle meal 205 ~ 245 parts, 35 ~ 47 parts, Radix Glycyrrhizae.
In above-mentioned sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations, described B B-complex comprises following parts by weight of component: the vitamin D that 10 ~ 15 parts of specifications are the retinyl acetate pulvis of 500,000 IU/g, 20 ~ 30 parts of DL-ɑ-tocopherol acetate weight percent contents are the DL-ɑ-tocopherol acetate pulvis of 50%, 5 ~ 8 parts of specifications are 500,000 IU/g
3pulvis, 0.5 ~ 1.0 part of menadione sodium bisulfite, 1.0 ~ 2.0 parts of thiamine hydrochlorides, 1.5 ~ 2.5 parts of riboflavin, 1.0 ~ 1.5 parts of puridoxine hydrochlorides, 0.2 ~ 0.5 part of cyanocobalamin mass percentage content are the cyanocobalamin preparation of 2%, 10 ~ 15 parts of calcium pantothenates, 10 ~ 15 parts of nicotinic acid, 0.3 ~ 0.6 part of Bio mass percentage content are 2% Bio preparation, 5 ~ 10 parts of betaines.
Preferably, described B B-complex comprises following parts by weight of component: the vitamin D that 11 ~ 14 parts of specifications are the retinyl acetate pulvis of 500,000 IU/g, 21 ~ 29 parts of DL-ɑ-tocopherol acetate weight percent contents are the DL-ɑ-tocopherol acetate pulvis of 50%, 5.5 ~ 7.5 parts of specifications are 500,000 IU/g
3pulvis, 0.6 ~ 0.9 part of menadione sodium bisulfite, 1.1 ~ 1.9 parts of thiamine hydrochlorides, 1.6 ~ 2.4 parts of riboflavin, 1.1 ~ 1.4 parts of puridoxine hydrochlorides, 0.25 ~ 0.45 part of cyanocobalamin mass percentage content are the cyanocobalamin preparation of 2%, 11 ~ 14 parts of calcium pantothenates, 11 ~ 14 parts of nicotinic acid, 0.35 ~ 0.55 part of Bio mass percentage content are 2% Bio preparation, 6 ~ 9 parts of betaines.
In above-mentioned sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations, described compound amino acid is silkworm compound amino acid.
In above-mentioned sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations, described polysaccharide comprises following parts by weight of component: 25 ~ 35 parts of yeast cell wall polysaccharide, 50 ~ 75 parts of FOSs.Preferably, yeast cell wall polysaccharide is 28 ~ 32 parts, and FOS is 55 ~ 72 parts of FOSs.
In above-mentioned sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations, also comprise: 8 ~ 12 weight portion zinc methionines, 2.5 ~ 5 weight portion yeast seleniums, 25 ~ 35 parts of dihydropyridines; Preferably, zinc methionine is 8.5 ~ 11.5 weight portions, and yeast selenium is 3 ~ 4.5 weight portions, and dihydropyridine is 26 ~ 33 weight portions.
In above-mentioned sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations, also comprise antioxidant; Described antioxidant comprises 0.3 ~ 0.8 part of sodium hydrogensulfite, 0.1 ~ 0.3 part of BHT; Preferably, described sodium hydrogensulfite 0.4 ~ 0.7 weight portion, described BHT is 0.15 ~ 0.25 weight portion.
The present invention also provides the preparation method of above-mentioned sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations, and described preparation method is specially:
Pre-blend step: take the premixed of B B-complex, compound amino acid and part compound Chinese medicine fermentation fine powder according to weight portion;
Blend step: the compound Chinese medicine fermentation fine powder and the above-mentioned material through premixed that take polysaccharide and surplus by weight carry out being mixed to get product.
In the preparation method of above-mentioned sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations, in described pre-blend step, also be added with antioxidant, described antioxidant is specially 0.3 ~ 0.8 part of sodium hydrogensulfite, 0.1 ~ 0.3 part of BHT, preferably, described sodium hydrogensulfite 0.4 ~ 0.7 weight portion, described BHT is 0.15 ~ 0.25 weight portion; The weight of the compound Chinese medicine fermentation fine powder in described pre-blend step is the gross weight of antioxidant, B B-complex, compound amino acid.
In the preparation method of above-mentioned sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations, in described blend step, be also added with 8 ~ 12 weight portion zinc methionines, 2.5 ~ 5 weight portion yeast seleniums, 25 ~ 35 parts of dihydropyridines; Preferably, zinc methionine is 8.5 ~ 11.5 weight portions, and yeast selenium is 3 ~ 4.5 weight portions, and dihydropyridine is 26 ~ 33 weight portions.
In the preparation method of above-mentioned sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations, described compound Chinese medicine fermentation fine powder is prepared by following steps:
Step 1: be mixed to get fine powder mixture with glucose after Chinese medicine material preparation is become fine powder and pour the fermentation tank being with stirring arm into, add boiling drinking water while stirring to fine powder mixture water content 35 ~ 40%, stop stirring and be airtightly down to 40 DEG C ± 2 DEG C to fine powder mixture temperature;
Step 2: add the bafillus natto bacteria suspension after twice subculture, Bacillus licheniformis suspension while stirring, fine powder mixture weight 1.0% before the weight of bafillus natto bacteria suspension, Bacillus licheniformis suspension is respectively and adds water, stir, keep 38-40 DEG C, period stirred 5 minutes every 2 hours, and kept ventilating to provide sufficient oxygen.
Step 3: after aerobic fermentation 36h, stirs and is cooled to 34 ± 2 DEG C, add the lactobacillus acidophilus bacteria suspension after twice subculture, and the weight of lactobacillus acidophilus bacteria suspension is 1.0% of the weight of fine powder mixture before adding water, more airtight static anaerobic fermentation 72h;
Step 4: the mixture obtained through step 3 is shakeout and cools;
Step 5: mixture vacuum drying step 4 obtained, to water content≤8%, obtains compound Chinese medicine fermentation fine powder.
In the preparation method of above-mentioned sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations, the particle diameter of described fine powder is 40 orders.
In the preparation method of above-mentioned sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations, the viable count of described bafillus natto bacteria suspension is 2.5 × 10
8cFU/g; The viable count of described bafillus natto bacteria suspension is 2.5 × 10
8cFU/g; The viable count of described lactobacillus acidophilus bacteria suspension is 5.0 × 10
8cFU/g.
In the preparation method of above-mentioned sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations, natto Bacillus viable count>=1.20 × 10 in described compound Chinese medicine fermentation fine powder
10cFC/g, bacillus licheniformis viable count>=5.00 × 10
9cFC/g, live lactobacillus acidophilus number>=8.00 × 10
9cFC/g.
The present invention also provides the application of above-mentioned sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations, adds the sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations being equivalent to sow feed weight 0.2% in sow feed.
Beneficial effect of the present invention is as follows:
1. product of the present invention is according to the physilogical characteristics of sow and nutritional need, the raw materials such as selected high-quality liposoluble vitamin, water soluble vitamin, silkworm compound amino acid, yeast cell wall polysaccharide, FOS, yeast selenium, zinc methionine, dihydropyridine, with composite fermentation Chinese medicine powder for functional vector, make needed for the nutrition that has and supplement fast between sow reproduction period, and have nourishing qi and blood, the B B-complex fermented tcm preparation of nourishing the fetus effect of preventing miscarriage.Functional vector of the present invention is according to fermentable Chinese herbal medicine principle, with the bighead atractylodes rhizome, Radix Angelicae Sinensis, Ligusticum wallichii, Radix Codonopsis, the Radix Astragali, dried orange peel, tarragon, rice sprout, pine needle meal, the traditional Chinese medicine ingredients prescriptions such as Radix Glycyrrhizae, utilize bafillus natto, bacillus licheniformis, the bacterial classifications such as lactobacillus acidophilus, by pulverizing, addicted to aerobe fermentation, anaerobic fermentation and vacuum dehydrating at lower temperature PROCESS FOR TREATMENT, make and there is nourishing qi and blood, antiabortive, warming kidney and strengthening spleen, protection embryo nidation, to prevent miscarriage nourishing the fetus, strengthen the compound microorganism ferments Chinese herbal medicine powder of immunologic function effect, as the functional vector of B B-complex premixed feed, mutually collaborative nutrition health-care functions is produced with B B-complex.Sow is by becoming pregnant to the whole reproductive process of production regularly by 0.2% use product of the present invention, significantly can improve pregnancy rate, improve litter size, improve piglet survival ratio and strong young rate, strengthen sow immunologic function, improve resisting stress and resistance against diseases, and have the effect of nourishing qi and blood, antiabortive, warming kidney and strengthening spleen, protection embryo nidation, nourishing the fetus of preventing miscarriage; Easy to use, use cost is low, nonreactive, drug residue free, to have no drug resistance, and effectively can reduce the generation of various common disease, the antibiotic use of effective minimizing, meet the industrial policy of the green nonreactive healthy aquaculture of the current promotion of China, of the present inventionly widely popularize application there is good economic benefit and social benefit.
2. vitamin maintains cultivated animals health and the important trace nutrient needed for normal growth growth, it is the main nutrients in six large nutritional factors, it is maintaining the power conversion of body, is preventing all having the effect do not replaced in vitamin-deficiency and metabolism etc., it is a kind of Nutrition and Metabolism that coenzyme participates in body, be the nutrient lacked most in complete diet pellet, its mechanism of action and practical application effect have obtained the approval of numerous raisers.Amino acid is the necessary base substance of animal growth, and its physiological action promotes protein synthesis, stimulating growth hormone secretion, and protection liver function, whets the appetite, and improves the immunocompetence of body, promotes to heal after being ill.Silkworm compound amino acid is hydrolyzed extraction by silkworm chrysalis degreasing to form, containing 18 seed amino acids such as valine, phenylalanine, asparatates, total amino acid >=79.5%, various amino acid whose content ratio closest to sow grow and needed for producing.
3. the main component of yeast cell wall polysaccharide is glucan and mannosan, can the propagation of stimulating animal body endolymph cell, macrophage in activating animals body, increase the ability that animal body produces NK, lure that animal produces nospecific immunity to coccidioidomycosis into, improve survival rate, maintain microecological balance and strengthen animal immunizing power, improve animal health condition, increase the adaptability of animal pessimal stimulation to external world.And it can identify pathogenic microorganism, adheres to and get rid of, by Tiny ecosystem structure in regulation and control animal alimentary canal, useful health-care effect is played to host.FOS participates in Cellular Immunity directly as immunologic adjuvant and antigen and humoral immunity regulates, promote hepatic secretion glycoprotein, immune response is caused in conjunction with bacterium, with the PHA specific binding on pathogen surface, slow down antigen to absorb, stimulate body immune system, improve the immune response ability of animal.
4. selenium is growth of animal metabolism and breeds necessary trace element, and, resisting stress, raising immunity etc. anti-oxidant to body play an important role, and yeast selenium belongs to the organic selenium source of first-selected high-quality, and absorptivity is high.Selenium protects sperm motility, embryo nidation etc. from oxidative damage by the antioxidation of glutathione peroxidase, to improve immunity and reproductive performance.Zinc is component and the activator of multiple enzyme in animal body, many enzymes just have activity and reach maximum enzyme under zinc existent condition lives, simultaneously, zinc grows and the necessary trophic factors of immune response as immune organ, it is the important element participating in immunologic function directly, it has important effect to promotion humoral immunity, cellular immunity and mucosa-immune, can improve T Lymphocyte transformation index, can also reduce the loss etc. of vitamin.Dihydropyridine has antioxidation, there is some function of natural VE, also can significantly increasing serum follicle-stimulating hormone (FSH) (FSH) and metakentrin (LH) content, the g and D of indirect promotion ovarian follicle, stronger stabilization is have to VA, VE and carrot, be impregnated (essence) rate, incubation rate, laying rate, the semen quality of livestock and poultry can be improved.
5. fermentable Chinese herbal medicine is with a long history, microorganism species can tens kinds of ectoenzymes such as extracellular proteinase, cellulase, hemicellulase, pectase, amylase in growth metabolism process, what these enzymes had have oxidation, esterification, methylate, the multiple biotransformation capacity such as hydroxylating, reducing, by drug ingedient decomposition and inversion, new compound can be formed; The cellulose, hemicellulose, pectic substance etc. of hydrolyzable plant cell wall, make cell rupture, be beneficial to active ingredient stripping; The mass degradations such as the cellulose in cell membrane and cytoplasm, hemicellulose can be made, make cell rupture, space between cells increase, reduce cell membrane, intercellular substance transmit barrier, to active ingredient from born of the same parents to the drag reduction of born of the same parents' external diffusion, can promote that the absorption of active ingredient improves; Macromolecular substances in Chinese herbal medicine can be transformed into the small-molecule substance that directly can be absorbed by animal body enteron aisle, effectively raise bioavilability, decrease using dosage, saved drug cost and herb resource.Reusing bighead atractylodes rhizome strengthening the spleen and replenishing qi, antiabortive in functional vector fermented tcm prescription of the present invention, is monarch drug in a prescription; Radix Codonopsis, the Radix Astragali help the bighead atractylodes rhizome to replenish qi to invigorate the spleen with solid feotus vitality, Radix Angelicae Sinensis, Ligusticum wallichii nourish blood and blood with nourishing the fetus unit, be ministerial drug altogether; Help with tarragon that warming channel and expelling cold dried orange peel is regulated the flow of vital energy antiabortive with antiabortive, and gas of being amusing, in case all qi-replenishing and blood-enriching medicines are grown and greasyly hindered stomach, rice sprout tonifying spleen nourishing the stomach is antiabortive altogether for adjutant to help, Radix Glycyrrhizae benefit gas with in, coordinating the drug actions of a prescription, for making medicine; All medicines share plays nourishing qi and blood, antiabortive, warming kidney and strengthening spleen, protection embryo nidation, nourishing the fetus of preventing miscarriage, the effect that improves pregnancy rate, improve litter size, improve piglet survival ratio and strong young rate altogether.Pine needle meal is nutritious, containing thick protein 7%-12%, total amino acid content reaches 5.5%-8.1%, containing crude fat 7%-12%, NFE 37%, ash content 2%-6%, the trace element such as iron, manganese, cobalt kind more than 40, pine needle meal contains vitamin A, B race, C, K, E etc., is the good nutrition material cultivating the growth of microorganism such as bafillus natto, bacillus licheniformis, lactobacillus acidophilus, is also the additive for farm animal feed that a kind of nutritive value of developing of people is higher in recent years.Above prescription Chinese medicine by bafillus natto, bacillus licheniformis, lactobacillus acidophilus addicted to aerobe fermentation, anaerobic fermentation and vacuum dehydrating at lower temperature PROCESS FOR TREATMENT, be rich in the multiple digestive ferments such as Nattokinase, alkali protease, cellulase, hemicellulase, pectase, amylase, and natto rhzomorph, lactobacillin, addicted to antibacterial peptide matters such as yogurt element, sour rhzomorphs, the vitamins such as vitamin K, nicotinic acid, B family vitamin, and containing a large amount of useful gemma viable bacteria and the organic acid such as lactic acid, acetic acid.After fermentation, absorptivity is than high more than 3 times before not fermenting, and therefore the present invention uses the effect that can meet or exceed front prescription use of not fermenting by the dosage of the front prescription 1/3rd that do not ferment, and has saved drug cost and a large amount of Chinese material medicine resource.
6. China is world population big country, has nearly 1,500,000,000 populations, accounts for world population 1/4th, is also livestock and poultry cultivation and consumption big country, China's annual pig, cattle and sheep poultry output 8,540 ten thousand tons in 2014, wherein pork output 5,671 ten thousand tons; Annual birds, beasts and eggs output 2,894 ten thousand tons, milk crop 3,725 ten thousand tons; Annual live pig delivers 73,510 ten thousand for sale; The year end live pig livestock on hand 46,583 ten thousand.Because livestock and poultry breeding scale pollution prevention ordinance enforces, live pig delivers price continued downturn for sale, the Ministry of Agriculture announces official website 4000 monitoring point live pig livestock on hand information December in 2014, data display numerous sow breeding stock can fall to forty-two million head, estimate the numerous sow livestock on hands of energy in 2015 or recompression, the early warning bottom line of nearly 4,000 ten thousand can be fallen to.The present invention to make an addition in the feed of front and back sow of becoming pregnant spice and feeds in the ratio of 0.2% and raise, good nourishing qi and blood can be reached, antiabortive, warming kidney and strengthening spleen, protection embryo nidation, to prevent miscarriage nourishing the fetus, improve pregnancy rate, the effect of strong young rate, litter size 2-4 head/year can be improved, improve piglet survival ratio 8-15%, and farrowing sow constipation can be reduced, the generation of the various common diseases such as diarrhoea, effective maintenance intestinal health, reduce antibiotic use, promote digesting and assimilating of feed, reduce ight soil ammonia stink, reduce the discharge of breeding pollution thing, improve the object of fanning economics.Use cost is low, drug residue free, has no drug resistance, and meets the healthy aquaculture policy that China advocates, has good popularizing application prospect, have good economic benefit and social benefit.
Detailed description of the invention
Below in conjunction with detailed description of the invention, technical scheme of the present invention is described in further detail, but does not form any limitation of the invention.
Embodiment 1
1, the preparation of fermented tcm fine powder:
1.1 take the drying traditional Chinese medicinal materials medicine materical crude slice without going mouldy, damaging by worms, bighead atractylodes rhizome 57kg, tarragon 55kg, Radix Angelicae Sinensis 30kg, Ligusticum wallichii 25kg, Radix Codonopsis 45kg, Radix Astragali 40kg, dried orange peel 45kg, rice sprout 65kg, pine needle meal 115kg, Radix Glycyrrhizae 20kg, be ground into 40 orders, obtain 497kg traditional Chinese medicine fine powder (water content about 10%).
1.2, the preparation of bacteria suspension:
Bafillus natto, bacillus licheniformis activate respectively, twice squamous subculture, respectively make 5kg, are about respectively 2.5 × 10 containing viable count
8the bacteria suspension of CFU/g; Lactobacillus acidophilus activates respectively, twice squamous subculture, makes 5kg, containing viable count about 5.0 × 10
8cFU/g lactobacillus acidophilus bacteria suspension.
1.3,3kg glucose is taken, for subsequent use.
1.4, fermentation step:
Step 1.1: take the fermentation tank that recipe quantity traditional Chinese medicine fine powder 497kg pours band stirring arm into, add 3kg glucose, stir, add boiling drinking water 200kg while stirring, stop stirring and be airtightly down to about 40 ± 2 DEG C to traditional Chinese medicine fine powder temperature, add the bafillus natto bacteria suspension after twice subculture, each 5kg of bacillus licheniformis while stirring, stir, keep 38-40 DEG C, period stirred 5 minutes every 2 hours, and keep ventilating to provide sufficient oxygen, continuing fermentation 36h.
Step 1.2: after fermentation 36h, stir and be cooled to 34 ± 2 DEG C, add the lactobacillus acidophilus bacteria suspension 5kg after twice subculture while stirring, stir, keep 33-35 DEG C, more airtight static fermentation 72h.
Step 1.3: the traditional Chinese medicine fine powder 713kg after continuously fermenting 108h through bafillus natto, bacillus licheniformis, lactobacillus acidophilus is poured out in stainless steel holder basin and shakeouts, about 2-3cm is thick, cools to room temperature;
Step 1.4: the fermented tcm fine powder after cooling is put into vacuum drying chamber, start and vacuumize and heat, vacuum degree control is at 0.095MPa, and heating and temperature control is at 45-50 DEG C, be dried to fermented tcm fine powder water content≤8%, detect natto Bacillus viable count>=1.20 × 10
10cFC/g, bacillus licheniformis viable count>=5.00 × 10
9cFC/g, live lactobacillus acidophilus number>=8.00 × 10
9cFC/g, crosses 40 order stainless steel mesh, obtains the dry fermented tcm fine powder of about 495kg.
2. the preparation of compound premixed feed:
Step 2.1: take retinyl acetate (500,000 IU/g): 6kg, DL-ɑ-tocopherol acetate (50%): 12kg, vitamin D
3(500,000 IU/g): 3kg, menadione sodium bisulfite: 0.4kg; Thiamine hydrochloride: 0.8kg, riboflavin: 1.0kg, puridoxine hydrochloride: 0.6kg, cyanocobalamin (2%): 0.2kg; Bio (2%): 0.25kg, betaine 4kg, sodium hydrogensulfite 0.2kg, BHT:0.1kg, with the premixed of equivalent 28.6kg fermented tcm fine powder, for subsequent use;
Step 2.2: take calcium pantothenate: 6kg, nicotinic acid: 6kg, silkworm compound amino acid 4kg, yeast cell wall polysaccharide 15kg, dihydropyridine 15kg, zinc methionine 5kg, yeast selenium 2kg, FOS 30kg, fermented tcm fine powder 360kg, put into three-dimensional mixer and mix about 5 minutes;
Step 2.3: step 2.1 gained material join in three-dimensional mixer with step 2.2 mixing of materials about 15 minutes, must about 500kg color uniformity, without color spot, without the brownish-yellow powder shape compound premixed feed of caking, Workplace temperature requirement 18-25 DEG C, humidity requirement≤50%.
3. check:
2 gained brownish-yellow powder shape compound premixed feeds are carried out the detections such as sanitary index, moisture content, discriminating, content by quality criteria requirements, after qualified, obtains sample 1.
4. pack: the fermented tcm fine powder taking 1kg with the packaging bag of thickness 0.12mm fine aluminium, sealing, vanning (packing specification 1kg × 15 bag/case), check warehouse-in.
Quality standard:
1. sanitary index: GB 13078 requirement should be met, wherein total arsenic (in As)≤10mg/kg; Plumbous (in Pb)≤30mg/kg, fluorine (in F)≤1000mg/kg;
2. moisture content≤10% (GB/T 6435);
3. granularity: all by aperture be 1.19mm analyze sieve, aperture be 0.59mm analyze sieve oversize must not be greater than 10%.(GB/T5917.1)；
4. differentiate: in the chromatogram that (1) records under retinyl acetate assay item, the retention time at test sample peak should consistent with the retention time at retinyl acetate reference substance peak (GB/T 17817);
(2), in the chromatogram recorded under DL-ɑ-tocopherol acetate assay item, the retention time at test sample peak should consistent with the retention time at DL-ɑ-tocopherol acetate reference substance peak (GB/T 17812).
5. assay: retinyl acetate 500 ~ 7,500,000 IU/kg (GB/T 17817), DL-ɑ-tocopherol acetate>=10g/kg (GB/T 17812), vitamin D
3250 ~ 4,000,000 IU/kg (GB/T 17818).
Embodiment 2
1, the preparation of fermented tcm fine powder:
1.1 take the drying traditional Chinese medicinal materials medicine materical crude slice without going mouldy, damaging by worms, bighead atractylodes rhizome 52kg, tarragon 60kg, Radix Angelicae Sinensis 25kg, Ligusticum wallichii 30kg, Radix Codonopsis 40kg, Radix Astragali 35kg, dried orange peel 50kg, rice sprout 60kg, pine needle meal 125kg, Radix Glycyrrhizae 18kg, be ground into 40 orders, obtain 495kg traditional Chinese medicine fine powder (water content about 10%).
1.2, the preparation of bacteria suspension:
Bafillus natto, bacillus licheniformis activate respectively, twice squamous subculture, respectively make 5kg, are about respectively 2.5 × 10 containing viable count
8the bacteria suspension of CFU/g; Lactobacillus acidophilus activates respectively, twice squamous subculture, makes 5kg, containing viable count about 5.0 × 10
8cFU/g lactobacillus acidophilus bacteria suspension.
1.3,5kg glucose is taken, for subsequent use.
1.4, fermentation step:
Step 1.1: take the fermentation tank that recipe quantity traditional Chinese medicine fine powder 495kg pours band stirring arm into, add 5kg glucose, stir, add boiling drinking water 192.5kg while stirring, water content is 35%, stop stirring and be airtightly down to about 40 ± 2 DEG C to traditional Chinese medicine fine powder temperature, add the bafillus natto bacteria suspension after twice subculture, each 5kg of bacillus licheniformis while stirring, stir, keep 38-40 DEG C, period stirred 5 minutes every 2 hours, and kept ventilating to provide sufficient oxygen, continuing fermentation 36h.
Step 1.2: fermentation 36h (is 24 hours in book of telling somebody what one's real intentions are here, here change 36 hours into, with with corresponding above) after, stirring is cooled to 34 ± 2 DEG C, add the lactobacillus acidophilus bacteria suspension 5kg after twice subculture while stirring, stir, keep 33-35 DEG C, more airtight static fermentation 72h.
Step 1.3: the traditional Chinese medicine fine powder 710kg after continuously fermenting 108h through bafillus natto, bacillus licheniformis, lactobacillus acidophilus is poured out in stainless steel holder basin and shakeouts, about 2-3cm is thick, cools to room temperature;
Step 1.4: the fermented tcm fine powder after cooling is put into vacuum drying chamber, start and vacuumize and heat, vacuum degree control is at 0.095MPa, and heating and temperature control is at 45-50 DEG C, be dried to fermented tcm fine powder water content≤8%, detect natto Bacillus viable count>=1.20 × 10
10cFC/g, bacillus licheniformis viable count>=5.00 × 10
9cFC/g, live lactobacillus acidophilus number>=8.00 × 10
9cFC/g, crosses 40 order stainless steel mesh, obtains the dry fermented tcm fine powder of about 495kg.
2. the preparation of compound premixed feed:
Step 2.1: take retinyl acetate (500,000 IU/g): 5kg, DL-ɑ-tocopherol acetate (50%): 15kg, vitamin D
3(500,000 IU/g): 2.5kg, menadione sodium bisulfite: 0.5kg; Thiamine hydrochloride: 1kg, riboflavin: 0.75kg, puridoxine hydrochloride: 0.7kg, cyanocobalamin (2%): 0.1kg; Bio (2%): 0.3kg, betaine 2.5kg, sodium hydrogensulfite 0.15kg, BHT:0.15kg, with the premixed of equivalent 28.65kg fermented tcm fine powder, for subsequent use;
Step 2.2: take calcium pantothenate: 5kg, nicotinic acid: 7.5kg, silkworm compound amino acid 2.5kg, yeast cell wall polysaccharide 17.5kg, dihydropyridine 12.5kg, zinc methionine 4kg, yeast selenium 2.5kg, FOS 25kg, fermented tcm fine powder 366.2kg, put into three-dimensional mixer and mix about 5 minutes;
Step 2.3: step 2.1 gained material join in three-dimensional mixer with step 2.2 mixing of materials about 15 minutes, must about 500kg color uniformity, without color spot, without the brownish-yellow powder shape compound premixed feed of caking, Workplace temperature requirement 18-25 DEG C, humidity requirement≤50%.
3. check:
2 gained brownish-yellow powder shape compound premixed feeds are carried out the detections such as sanitary index, moisture content, discriminating, content by quality criteria requirements, after qualified, obtains product.
4. pack: the fermented tcm fine powder taking 1kg with the packaging bag of thickness 0.12mm fine aluminium, sealing, vanning (packing specification 1kg × 15 bag/case), check warehouse-in.
Quality standard:
1. sanitary index: GB 13078 requirement should be met, wherein total arsenic (in As)≤10mg/kg; Plumbous (in Pb)≤30mg/kg, fluorine (in F)≤1000mg/kg;
2. moisture content≤10% (GB/T 6435);
3. granularity: all by aperture be 1.19mm analyze sieve, aperture be 0.59mm analyze sieve oversize must not be greater than 10%.(GB/T5917.1)；
4. differentiate: in the chromatogram that (1) records under retinyl acetate assay item, the retention time at test sample peak should consistent with the retention time at retinyl acetate reference substance peak (GB/T 17817);
(2), in the chromatogram recorded under DL-ɑ-tocopherol acetate assay item, the retention time at test sample peak should consistent with the retention time at DL-ɑ-tocopherol acetate reference substance peak (GB/T 17812).
5. assay: retinyl acetate 500 ~ 7,500,000 IU/kg (GB/T 17817), DL-ɑ-tocopherol acetate>=10g/kg (GB/T 17812), vitamin D
3250 ~ 4,000,000 IU/kg (GB/T 17818).
Embodiment 3
1, the preparation of fermented tcm fine powder:
1.1 take the drying traditional Chinese medicinal materials medicine materical crude slice without going mouldy, damaging by worms, bighead atractylodes rhizome 60kg, tarragon 50kg, Radix Angelicae Sinensis 35kg, Ligusticum wallichii 18kg, Radix Codonopsis 50kg, Radix Astragali 47kg, dried orange peel 40kg, rice sprout 75kg, pine needle meal 100kg, Radix Glycyrrhizae 22kg, be ground into 40 orders, obtain 498kg traditional Chinese medicine fine powder (water content about 10%).
1.2, the preparation of bacteria suspension:
Bafillus natto, bacillus licheniformis activate respectively, twice squamous subculture, respectively make 5kg, are about respectively 2.5 × 10 containing viable count
8the bacteria suspension of CFU/g; Lactobacillus acidophilus activates respectively, twice squamous subculture, makes 5kg, containing viable count about 5.0 × 10
8cFU/g lactobacillus acidophilus bacteria suspension.
1.3,2.5kg glucose is taken, for subsequent use.
1.4, fermentation step:
Step 1.1: take the fermentation tank that recipe quantity traditional Chinese medicine fine powder 498kg pours band stirring arm into, add 2.5kg glucose, stir, add boiling drinking water 250kg while stirring, water content 40%, stop stirring and be airtightly down to about 40 ± 2 DEG C to traditional Chinese medicine fine powder temperature, add the bafillus natto bacteria suspension after twice subculture, each 5kg of bacillus licheniformis while stirring, stir, keep 38-40 DEG C, period stirred 5 minutes every 2 hours, and kept ventilating to provide sufficient oxygen, continuing fermentation 36h.
Step 1.2: fermentation 36h (is 24 hours in book of telling somebody what one's real intentions are here, here change 36 hours into, with with corresponding above) after, stirring is cooled to 34 ± 2 DEG C, add the lactobacillus acidophilus bacteria suspension 5kg after twice subculture while stirring, stir, keep 33-35 DEG C, more airtight static fermentation 72h.
Step 1.3: the traditional Chinese medicine fine powder 715kg after continuously fermenting 108h through bafillus natto, bacillus licheniformis, lactobacillus acidophilus is poured out in stainless steel holder basin and shakeouts, about 2-3cm is thick, cools to room temperature;
Step 1.4: the fermented tcm fine powder after cooling is put into vacuum drying chamber, start and vacuumize and heat, vacuum degree control is at 0.095MPa, and heating and temperature control is at 45-50 DEG C, be dried to fermented tcm fine powder water content≤8%, detect natto Bacillus viable count>=1.20 × 10
10cFC/g, bacillus licheniformis viable count>=5.00 × 10
9cFC/g, live lactobacillus acidophilus number>=8.00 × 10
9cFC/g, crosses 40 order stainless steel mesh, obtains the dry fermented tcm fine powder of about 495kg.
2. the preparation of compound premixed feed:
Step 2.1: take retinyl acetate (500,000 IU/g): 7.5kg, DL-ɑ-tocopherol acetate (50%): 10kg, vitamin D
3(500,000 IU/g): 4kg, menadione sodium bisulfite: 0.25kg; Thiamine hydrochloride: 0.5kg, riboflavin: 1.25kg, puridoxine hydrochloride: 0.5kg, cyanocobalamin (2%): 0.25kg; Bio (2%): 0.15kg, betaine 5kg, sodium hydrogensulfite 0.4kg, BHT:0.05kg, with the premixed of equivalent 29.85kg fermented tcm fine powder, for subsequent use;
Step 2.2: take calcium pantothenate: 7.5kg, nicotinic acid: 5kg, silkworm compound amino acid 5kg, yeast cell wall polysaccharide 12.5kg, dihydropyridine 17.5kg, zinc methionine 6kg, yeast selenium 1.25kg, FOS 37.5kg, fermented tcm fine powder 348kg, put into three-dimensional mixer and mix about 5 minutes;
Step 2.3: step 2.1 gained material join in three-dimensional mixer with step 2.2 mixing of materials about 15 minutes, must about 500kg color uniformity, without color spot, without the brownish-yellow powder shape compound premixed feed of caking, Workplace temperature requirement 18-25 DEG C, humidity requirement≤50%.
3. check:
2 gained brownish-yellow powder shape compound premixed feeds are carried out the detections such as sanitary index, moisture content, discriminating, content by quality criteria requirements, after qualified, obtains product.
4. pack: the fermented tcm fine powder taking 1kg with the packaging bag of thickness 0.12mm fine aluminium, sealing, vanning (packing specification 1kg × 15 bag/case), check warehouse-in.
Quality standard:
1. sanitary index: GB 13078 requirement should be met, wherein total arsenic (in As)≤10mg/kg; Plumbous (in Pb)≤30mg/kg, fluorine (in F)≤1000mg/kg;
2. moisture content≤10% (GB/T 6435);
3. granularity: all by aperture be 1.19mm analyze sieve, aperture be 0.59mm analyze sieve oversize must not be greater than 10%.(GB/T5917.1)；
4. differentiate: in the chromatogram that (1) records under retinyl acetate assay item, the retention time at test sample peak should consistent with the retention time at retinyl acetate reference substance peak (GB/T 17817);
(2), in the chromatogram recorded under DL-ɑ-tocopherol acetate assay item, the retention time at test sample peak should consistent with the retention time at DL-ɑ-tocopherol acetate reference substance peak (GB/T 17812).
5. assay: retinyl acetate 500 ~ 7,500,000 IU/kg (GB/T 17817), DL-ɑ-tocopherol acetate>=10g/kg (GB/T 17812), vitamin D
3250 ~ 4,000,000 IU/kg (GB/T 17818).
The preparation of contrast sample 1
1, the preparation of traditional Chinese medicine fine powder:
Take the drying traditional Chinese medicinal materials medicine materical crude slice without going mouldy, damaging by worms, bighead atractylodes rhizome 57kg, tarragon 55kg, Radix Angelicae Sinensis 30kg, Ligusticum wallichii 25kg, Radix Codonopsis 45kg, Radix Astragali 40kg, dried orange peel 45kg, rice sprout 65kg, pine needle meal 115kg, Radix Glycyrrhizae 20kg, be ground into 40 orders, obtain 497kg traditional Chinese medicine fine powder (water content about 10%), for subsequent use.
2. the preparation of compound premixed feed:
Step 2.1: take retinyl acetate (500,000 IU/g): 2kg, DL-ɑ-tocopherol acetate (50%): 4kg, vitamin D
3(500,000 IU/g): 1kg, menadione sodium bisulfite: 0.13kg; Thiamine hydrochloride: 0.27kg, riboflavin: 0.33kg, puridoxine hydrochloride: 0.2kg, cyanocobalamin (2%): 0.07kg; Bio (2%): 0.08kg, betaine 1.33kg, sodium hydrogensulfite 0.07kg, BHT:0.03kg, with the premixed of equivalent 17.5kg traditional Chinese medicine fine powder, for subsequent use;
Step 2.2: take calcium pantothenate: 2kg, nicotinic acid: 3.67kg, silkworm compound amino acid 1.33kg, yeast cell wall polysaccharide 5kg, dihydropyridine 5kg, zinc methionine 1.67kg, yeast selenium 0.67kg, glucose 1kg, FOS 10kg, traditional Chinese medicine fine powder 435kg, puts into three-dimensional mixer and mixes about 5 minutes;
Step 2.3: step 2.1 gained material join in three-dimensional mixer with step 2.2 mixing of materials about 15 minutes, must about 500kg color uniformity, without color spot, without the brownish-yellow powder shape compound premixed feed of caking, Workplace temperature requirement 18-25 DEG C, humidity requirement≤50%.
3. check:
2 gained brownish-yellow powder shape compound premixed feeds are carried out the detections such as sanitary index, moisture content, discriminating, content by quality criteria requirements, after qualified, obtains comparative sample 1.
4. pack: the fermented tcm fine powder taking 1kg with the packaging bag of thickness 0.12mm fine aluminium, sealing, vanning (packing specification 1kg × 15 bag/case), check warehouse-in.
Quality standard:
1. sanitary index: GB 13078 requirement should be met, wherein total arsenic (in As)≤10mg/kg; Plumbous (in Pb)≤30mg/kg, fluorine (in F)≤1000mg/kg;
2. moisture content≤10% (GB/T 6435);
3. granularity: all by aperture be 1.19mm analyze sieve, aperture be 0.59mm analyze sieve oversize must not be greater than 10%.(GB/T5917.1)；
4. differentiate: in the chromatogram that (1) records under retinyl acetate assay item, the retention time at test sample peak should consistent with the retention time at retinyl acetate reference substance peak (GB/T 17817);
(2), in the chromatogram recorded under DL-ɑ-tocopherol acetate assay item, the retention time at test sample peak should consistent with the retention time at DL-ɑ-tocopherol acetate reference substance peak (GB/T 17812).
5. assay: retinyl acetate 167 ~ 2,500,000 IU/kg (GB/T 17817), DL-ɑ-tocopherol acetate>=3.3g/kg (GB/T 17812), vitamin D
384 ~ 1,330,000 IU/kg (GB/T 17818).
The preparation of contrast sample 2
1, the preparation of fermented tcm fine powder:
1.1 take the drying traditional Chinese medicinal materials medicine materical crude slice without going mouldy, damaging by worms, bighead atractylodes rhizome 57kg, tarragon 55kg, Radix Angelicae Sinensis 30kg, Ligusticum wallichii 25kg, Radix Codonopsis 45kg, Radix Astragali 40kg, dried orange peel 45kg, rice sprout 65kg, pine needle meal 115kg, Radix Glycyrrhizae 20kg, be ground into 40 orders, obtain 497kg traditional Chinese medicine fine powder (water content about 10%).
1.2, the preparation of bacteria suspension:
Bafillus natto, bacillus licheniformis activate respectively, twice squamous subculture, respectively make 5kg, are about respectively 2.5 × 10 containing viable count
8the bacteria suspension of CFU/g; Lactobacillus acidophilus activates respectively, twice squamous subculture, makes 5kg, containing viable count about 5.0 × 10
8cFU/g lactobacillus acidophilus bacteria suspension.
1.3,3kg glucose is taken, for subsequent use.
1.4, fermentation step:
Step 1.1: take the fermentation tank that recipe quantity traditional Chinese medicine fine powder 497kg pours band stirring arm into, add 3kg glucose, stir, add boiling drinking water 200kg while stirring, stop stirring and be airtightly down to about 40 ± 2 DEG C to traditional Chinese medicine fine powder temperature, add the bafillus natto bacteria suspension after twice subculture, each 5kg of bacillus licheniformis while stirring, stir, keep 38-40 DEG C, period stirred 5 minutes every 2 hours, and keep ventilating to provide sufficient oxygen, continuing fermentation 36h.
Step 1.2: after fermentation 24h, stir and be cooled to 34 ± 2 DEG C, add the lactobacillus acidophilus bacteria suspension 5kg after twice subculture while stirring, stir, keep 33-35 DEG C, more airtight static fermentation 72h.
Step 1.3: the traditional Chinese medicine fine powder 713kg after continuously fermenting 108h through bafillus natto, bacillus licheniformis, lactobacillus acidophilus is poured out in stainless steel holder basin and shakeouts, about 2-3cm is thick, cools to room temperature;
Step 1.4: the fermented tcm fine powder after cooling is put into vacuum drying chamber, start and vacuumize and heat, vacuum degree control is at 0.095MPa, and heating and temperature control is at 45-50 DEG C, be dried to fermented tcm fine powder water content≤8%, detect natto Bacillus viable count>=1.20 × 10
10cFC/g, bacillus licheniformis viable count>=5.00 × 10
9cFC/g, live lactobacillus acidophilus number>=8.00 × 10
9cFC/g, crosses 40 order stainless steel mesh, obtains the dry fermented tcm fine powder of about 495kg.
2. the preparation of compound premixed feed:
Step 2.1: take retinyl acetate (500,000 IU/g): 6kg, DL-ɑ-tocopherol acetate (50%): 12kg, vitamin D
3(500,000 IU/g): 3kg, menadione sodium bisulfite: 0.4kg; Thiamine hydrochloride: 0.8kg, riboflavin: 1.0kg, puridoxine hydrochloride: 0.6kg, cyanocobalamin (2%): 0.2kg; Bio (2%): 0.25kg, betaine 4kg, sodium hydrogensulfite 0.2kg, BHT:0.1kg, with the premixed of equivalent 28.6kg fermented tcm fine powder, for subsequent use;
Step 2.2: take calcium pantothenate: 6kg, nicotinic acid: 11kg, silkworm compound amino acid 4kg, dihydropyridine 15kg, zinc methionine 5kg, yeast selenium 2kg, fermented tcm fine powder 400kg, puts into three-dimensional mixer and mixes about 5 minutes;
Step 2.3: step 2.1 gained material join in three-dimensional mixer with step 2.2 mixing of materials about 15 minutes, must about 500kg color uniformity, without color spot, without the brownish-yellow powder shape compound premixed feed of caking, Workplace temperature requirement 18-25 DEG C, humidity requirement≤50%.
3. check:
2 gained brownish-yellow powder shape compound premixed feeds are carried out the detections such as sanitary index, moisture content, discriminating, content by quality criteria requirements, obtains after qualified contrasting sample 2.
4. pack: the fermented tcm fine powder taking 1kg with the packaging bag of thickness 0.12mm fine aluminium, sealing, vanning (packing specification 1kg × 15 bag/case), check warehouse-in.
Quality standard:
1. sanitary index: GB 13078 requirement should be met, wherein total arsenic (in As)≤10mg/kg; Plumbous (in Pb)≤30mg/kg, fluorine (in F)≤1000mg/kg;
2. moisture content≤10% (GB/T 6435);
3. granularity: all by aperture be 1.19mm analyze sieve, aperture be 0.59mm analyze sieve oversize must not be greater than 10%.(GB/T5917.1)；
4. differentiate: in the chromatogram that (1) records under retinyl acetate assay item, the retention time at test sample peak should consistent with the retention time at retinyl acetate reference substance peak (GB/T 17817);
(2), in the chromatogram recorded under DL-ɑ-tocopherol acetate assay item, the retention time at test sample peak should consistent with the retention time at DL-ɑ-tocopherol acetate reference substance peak (GB/T 17812).
5. assay: retinyl acetate 500 ~ 7,500,000 IU/kg (GB/T 17817), DL-ɑ-tocopherol acetate>=10g/kg (GB/T 17812), vitamin D
3250 ~ 4,000,000 IU/kg (GB/T 17818).
Animal feeding embodiment 1
Sample 1, contrast sample 1 and contrast sample 2 are on the impact of sow production performance.
1. materials and methods
1.1 materials: get above-mentioned sample 1, contrast sample 1 and contrast sample 2 test material as the present embodiment 1.
1.2 for examination animal and grouping:
Subjects chooses source unanimously, health, age, body condition are close, and the farrowing time is identical, litter size identical (10, every nest), farrowing sex ratio is close, body weight is close, multiparity first parity, produces 25 days nest sons and to past the breast Du great Chang ternary sow, it is divided at random test I group by paired experiment principle, tests II group, tests III group and blank group totally 4 groups, often organize 3 repetitions, each repetition 10, totally 120.
1.3 test methods:
Test I group and add 0.2% sample 1 by feed mixing, test II group and add 0.6% contrast sample 1 by feed mixing, test III group and add 0.2% contrast sample 2, all to be used in conjunction the using priciple being used in conjunction 5 days for 5 days every 3 days again by feed mixing, circulation uses continuously, within just before giving birth front 3 days, stops using; Blank group only adds basal diet pellet and daily drinking water.Totally enclosed type pig house, roof ventilating fan ventilates, crack metal floor, and online flat foster, house temperature remains on 20 ~ 26 DEG C, and adopt the conventional feeding and management of sow, duration of test regularly cleans pig house, and presses vaccine program vaccinate.Note the heat condition of sow in latter 5 days of wean, first time artificial insemination breeding in 12-24 hour of oestrusing, carried out second time artificial insemination and breeds every 12 hours.Freely drink water in whole experimental period, restriction is fed, every bu early, 2 supplies in evening, the standard that conceived early stage, 2.2kg/ head/d pressed by daily ration supplies, and the standard that later stage of pregnancy, 2.7kg/ head/d pressed by daily ration supplies; Childbirth, to practice midwifery and the management work such as piglet heat-insulation, feed supplement, wean is carried out all routinely, test breeding cycle is 130 days.The concrete formula of sow (first 80 days) basal diet in conceived early stage is: corn 41.0%, wheat bran 20.0%, system chaff 14.0%, fermented bean dregs 5.0%, dregs of beans 7.0%, beans leaf powder 7.3%, oyster shell whiting 2%, stone flour 0.2%, salt 1%, lysine 0.5%, premix 2%; The concrete formula of sow in later stage of pregnancy (81-114 days) basal diet is: corn 50.0%, wheat bran 12.3%, fermented bean dregs 12.0%, dregs of beans 14.0%, beans leaf powder 6%, oyster shell whiting 1%, stone flour 0.2%, high-quality fish meal 1.0%, salt 1%, lysine 0.5%, premix 2%.
2. growth performance measures:
The oestrusing of duration of test record sow, breed, become pregnant and health status (incidence of constipation, diarrhoea and other diseases), survival rate, farrowing quantity, young birth counterpoise, survival rate, the young all body weight of wean.
2.1 results and data
Table one: oestrus of sow after weaned piglet, breed, return feelings and situation of becoming pregnant
| Group | Oestrus the date | Breeding date | Return feelings rate (%) | A successful pregnancies rate (%) |
| Test I group | 4-5 | 5-7 | 0 | 100 |
| Test II group | 4-5 | 5-7 | 0 | 100 |
| Test III group | 4-6 | 5-8 | 0 | 100 |
| Blank group | 4-8 | 5-9 | 6.67 | 93.33 |
Table two: nest litter size, birth weight, weanling weight and to number of weaned
| Group | Farrowing quantity/nest | Birth average weight | Wean average weight | To number of weaned (%) |
| Test I group | 11.5 | 1.45 | 7.75 | 96.67 |
| Test II group | 10.8 | 1.32 | 7.34 | 90.00 |
| Test III group | 10.2 | 1.31 | 7.02 | 86.67 |
| Blank group | 8.6 | 1.08 | 6.68 | 80.00 |
Table three: health status between sow whole reproduction period
| Group | Constipation incidence (%) | Incidence of Diarrhea (%) | Other diseases incidence (%) | Survival rate (%) |
| Test I group | 3.33 | 0.00 | 0.00 | 100 |
| Test II group | 6.67 | 10.00 | 3.33 | 100 |
| Test III group | 10.00 | 3.33 | 3.33 | 100 |
| Blank group | 40.00 | 26.67 | 13.33 | 96.67 |
Result of the test shows:
Found out by table one: oestrus date, pregnancy rate of sample 1 of feeding, contrast sample 1 group of Suprapubic arch sling is substantially identical, for the most desirable group of test group, blank group date of oestrusing postpones to some extent, part is had to return feelings after breeding, just become pregnant completely after secondary breeding, can all have with contrast sample 1 effect promoting oestrus of sow, unified pregnancy rate of oestrusing, improve by judgement sample 1.
Found out by table two: sample 1 group of Suprapubic arch sling nest farrowing more than contrast group 2.9 of quantity of feeding, birth weight 0.37kg more than control group, wean average weight 1.07kg more than control group, survival rate is higher than control group by 16.67%, is also each index peaks of all the other test group, promotion oestrus of sow can be had by judgement sample 1, improve pregnancy rate, improve farrowing rate, improve birth weight, improve weanling weight, improve the effect of number of weaned.
Found out by table three: feed sample 1 group of Suprapubic arch sling constipation incidence, Incidence of Diarrhea, other diseases incidence are in other test group and control group minimum, and sample 1 group of sow ight soil bar shaped of feeding, neither too hard, nor too soft, and defecation is less, and ammonia stink is lighter.Farrowing sow immunologic function and resistance against diseases can be improved by judgement sample 1, promote to digest and assimilate, promote intestines peristalsis, the effect of absorption excretion poisonous and harmful substance.
Although sample 1 can be found out by above three test datas and contrast sample 1 effect the most close, larger than sample 13 times of the addition of contrast sample 1, use cost many 1/2nd.Therefore can infer, a broad sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations of the present invention not only can significantly improve sow pregnancy rate, farrowing quantity, piglet birth weight, weaned piglet body weight and survival rate, and farrowing sow immunologic function and resistance against diseases can be improved, promotion is digested and assimilated, promote intestines peristalsis, absorption excretion poisonous and harmful substance, effectively reduces the generation of various disease, reduce use cost, improve fanning economics.
Above-describedly be only preferred embodiment of the present invention, all do within the scope of the spirit and principles in the present invention any amendment, equivalently to replace and improvement etc., all should be included within protection scope of the present invention.
Claims (15)
1. a broad sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations, it is characterized in that, the sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations of every 1000 weight portions comprises following parts by weight of component: 64.5 ~ 101.1 parts of B B-complexes, 5 ~ 10 parts of compound amino acids, 75 ~ 110 parts of polysaccharide, 819.6 ~ 725.8 parts of compound Chinese medicine fermentation fine powders, wherein, the compound Chinese medicine fermentation fine powder of every 1000 weight portions is obtained by following Chinese medicine material warp and 5 ~ 10 parts of glucose everfermentations: the bighead atractylodes rhizome 100 ~ 120 parts, tarragon 100 ~ 120 parts, Radix Angelicae Sinensis 50 ~ 70 parts, Ligusticum wallichii: 35 ~ 60 parts, Radix Codonopsis 80 ~ 100 parts, the Radix Astragali 100 ~ 70 parts, dried orange peel 100 ~ 80 parts, rice sprout 150 ~ 120 parts, pine needle meal 250 ~ 200 parts, 30 ~ 50 parts, Radix Glycyrrhizae.
2. sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations according to claim 1, it is characterized in that, described B B-complex comprises following parts by weight of component: the vitamin D that 10 ~ 15 parts of specifications are the retinyl acetate pulvis of 500,000 IU/g, 20 ~ 30 parts of DL-ɑ-tocopherol acetate weight percent contents are the DL-ɑ-tocopherol acetate pulvis of 50%, 5 ~ 8 parts of specifications are 500,000 IU/g
3pulvis, 0.5 ~ 1.0 part of menadione sodium bisulfite, 1.0 ~ 2.0 parts of thiamine hydrochlorides, 1.5 ~ 2.5 parts of riboflavin, 1.0 ~ 1.5 parts of puridoxine hydrochlorides, 0.2 ~ 0.5 part of cyanocobalamin mass percentage content are the cyanocobalamin preparation of 2%, 10 ~ 15 parts of calcium pantothenates, 10 ~ 15 parts of nicotinic acid, 0.3 ~ 0.6 part of Bio mass percentage content are 2% Bio preparation, 5 ~ 10 parts of betaines.
3. sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations according to claim 1, it is characterized in that, described compound amino acid is silkworm compound amino acid.
4. sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations according to claim 1, it is characterized in that, described polysaccharide comprises following parts by weight of component: 25 ~ 35 parts of yeast cell wall polysaccharide, 50 ~ 75 parts of FOSs.
5., according to the arbitrary described sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations of Claims 1-4, it is characterized in that, also comprise: 8 ~ 12 weight portion zinc methionines, 2.5 ~ 5 weight portion yeast seleniums, 25 ~ 35 parts of dihydropyridines.
6. sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations according to claim 5, is characterized in that, also comprise antioxidant.
7. sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations according to claim 6, is characterized in that, described antioxidant comprises 0.3 ~ 0.8 part of sodium hydrogensulfite, 0.1 ~ 0.3 part of BHT.
8. a preparation method for sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations as claimed in claim 1, it is characterized in that, described preparation method is specially:
Pre-blend step: take the premixed of B B-complex, compound amino acid and part compound Chinese medicine fermentation fine powder according to weight portion;
Blend step: the compound Chinese medicine fermentation fine powder and the above-mentioned material through premixed that take polysaccharide and surplus by weight carry out being mixed to get product.
9. the preparation method of sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations according to claim 8, it is characterized in that, in described pre-blend step, also be added with antioxidant, described antioxidant is specially 0.3 ~ 0.8 part of sodium hydrogensulfite, 0.1 ~ 0.3 part of BHT, and the weight of the compound Chinese medicine fermentation fine powder in described pre-blend step is the gross weight of antioxidant, B B-complex, compound amino acid.
10. the preparation method of sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations according to claim 9, is characterized in that, in described blend step, is also added with 8 ~ 12 weight portion zinc methionines, 2.5 ~ 5 weight portion yeast seleniums, 25 ~ 35 parts of dihydropyridines.
The preparation method of 11. according to Claim 8 ~ 10 arbitrary described sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparationses, is characterized in that, described compound Chinese medicine fermentation fine powder is prepared by following steps:
Step 1: be mixed to get fine powder mixture with glucose after Chinese medicine material preparation is become fine powder and pour the fermentation tank being with stirring arm into, add boiling drinking water while stirring to fine powder mixture water content 35 ~ 40%, stop stirring and be airtightly down to 40 DEG C ± 2 DEG C to fine powder mixture temperature;
Step 2: add the bafillus natto bacteria suspension after twice subculture, Bacillus licheniformis suspension while stirring, fine powder mixture weight 1.0% before the weight of bafillus natto bacteria suspension, Bacillus licheniformis suspension is respectively and adds water, stir, keep 38-40 DEG C, period stirred 5 minutes every 2 hours, and kept ventilating to provide sufficient oxygen.
Step 3: after aerobic fermentation 36h, stirs and is cooled to 34 ± 2 DEG C, add the lactobacillus acidophilus bacteria suspension after twice subculture, and the weight of lactobacillus acidophilus bacteria suspension is 1.0% of the weight of fine powder mixture before adding water, more airtight static anaerobic fermentation 72h;
Step 4: the mixture obtained through step 3 is shakeout and cools;
Step 5: mixture vacuum drying step 4 obtained, to water content≤8%, obtains compound Chinese medicine fermentation fine powder.
The preparation method of 12. sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparationses according to claim 11, it is characterized in that, the particle diameter of described fine powder is 40 orders.
The preparation method of 13. sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparationses according to claim 11, it is characterized in that, the viable count of described bafillus natto bacteria suspension is 2.5 × 10
8cFU/g; The viable count of described bafillus natto bacteria suspension is 2.5 × 10
8cFU/g; The viable count of described lactobacillus acidophilus bacteria suspension is 5.0 × 10
8cFU/g.
The preparation method of 14. sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparationses according to claim 11, is characterized in that, natto Bacillus viable count>=1.20 × 10 in described compound Chinese medicine fermentation fine powder
10cFC/g, bacillus licheniformis viable count>=5.00 × 10
9cFC/g, live lactobacillus acidophilus number>=8.00 × 10
9cFC/g.
The application of 15. 1 kinds of sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparationses as claimed in claim 1, is characterized in that, adds the sow specific complex fermentation process for vitamin production Chinese herbal and crude drugs preparations being equivalent to sow feed weight 0.2% in sow feed.
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Application publication date: 20150617 |