CN105327334A - Enteric coating pellets for treating piglet diarrhea and preparation method and application thereof - Google Patents
Enteric coating pellets for treating piglet diarrhea and preparation method and application thereof Download PDFInfo
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- CN105327334A CN105327334A CN201510691418.6A CN201510691418A CN105327334A CN 105327334 A CN105327334 A CN 105327334A CN 201510691418 A CN201510691418 A CN 201510691418A CN 105327334 A CN105327334 A CN 105327334A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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Abstract
The invention provides an enteric coating pellet for treating piglet diarrhea. The enteric coating pellet is prepared by antibacterial peptides, zinc oxide and pharmaceutically-acceptable auxiliary materials, wherein the antibacterial peptides and zinc oxide serve as active constituents. The enteric coating pellet comprises, by weight percentage, 70-90% of pellet core and 10-30% of enteric coating layer. The invention further provides a preparation method and application of the enteric coating pellet. The enteric coating pellet has the advantages that the diarrhea rate of weaned piglets can be lowered evidently, medicine which is efficient, low in price, simple, safe, non-irritant and free of residues is provided for veterinarians for clinically treating the piglet diarrhea, and the enteric coating pellet is promising in market prospect.
Description
Technical field
The present invention relates to a kind of enteric coated micropill for the treatment of piglet diarrhea and its production and use, belong to drug world.
Background technology
Piglet is due to intestinal structural development imperfection, and intestinal immunity is unsound, and self-resistance is more weak, is therefore very easy to intestinal tract disease occur, as HUANGBAI(sic) dysentery, transmissible gastroenteritis and epidemic diarrhea etc.Common antimicrobial agents, as gentamycin, enrofloxacin, LIJUNJING etc. prevent and treat piglet diarrhea.Have much in order to the husbandry sector person pursuing juice and largest production efficiency passes through to abuse the intestinal tract disease that feed additive and antibiotic etc treat domestic animal in recent years, cause feed additive to use excessive and pathogen to develop immunity to drugs and the series of problems such as livestock products drug residue, the alternative medicine therefore finding antibiotic feed additive is current problem demanding prompt solution.
Antibacterial peptide is made up of 12-100 amino acid residue usually, has powerful antibacterial action mainly for gram positive bacteria.Research finds that zinc oxide also has the effect for the treatment of piglet diarrhea, mainly can reduce the performance of gram negative bacteria virulence and the generation of toxin.
Because antibacterial peptide and zinc oxide are all unstable in gastric acid, antibacterial peptide is destructible in gastric acid, and zinc oxide generates zinc chloride in gastric acid, all causes antibacterial efficacy to reduce.And in breeding process, in order to play the Antidiarrheic effect of zinc oxide, raiser often adds the amount more than up to 3000g/ ton feedstuff, zinc ion can be caused excessive, cause poisoning, and a large amount of zinc can to bad environmental.Li Fangfang, Su Hang, Zhang Yong, the impact [J] on Growth Performance of Weaning Piglets and Biochemical Indices In Serum of recombinant antimicrobial peptide and coated zinc oxide is added Deng. diet. Animal nutrition journal 2015,27 (8): 1-8 disclose a kind of diet adding recombinant antimicrobial peptide and coated zinc oxide, wherein, the ratio of recombinant antimicrobial peptide and coated zinc oxide addition is 1:360.The diet of this interpolation recombinant antimicrobial peptide and coated zinc oxide fails to solve antibacterial peptide problem easily destroyed in gastric acid, does not also reduce the consumption of zinc oxide, and reduces the less effective of piglet diarrhea rate, only make piglet diarrhea rate reduce 9.18%.Therefore research and develop a kind of can ensure antibacterial peptide and zinc oxide drug effect, reduce drug dose and efficient, easy, inexpensive, the safe drugs that effectively can treat piglet diarrhea have very important significance to veterinary clinic treatment piglet diarrhea.
Summary of the invention
Technical scheme of the present invention there is provided a kind of enteric coated micropill for the treatment of piglet diarrhea and its production and use.
The invention provides a kind of enteric coated micropill for the treatment of piglet diarrhea, it by antibacterial peptide and zinc oxide be the ball core of active fraction preparation, enteric layer forms; Wherein, the percentage by weight of ball core, enteric layer is:
Ball core 70%-90%, enteric layer 10%-30%.
Preferably, described ball core, the percentage by weight of enteric layer are:
Ball core 80%, enteric layer 20%.
Wherein, in described ball core, supplementary material accounts for the percentage by weight of ball core and is:
Antibacterial peptide 20%-40%
Zinc oxide 20%-40%
Binding agent 20%-60%;
In described enteric layer, the percentage by weight that adjuvant accounts for enteric layer is:
Wherein, described binding agent is hydroxypropyl cellulose; Described enteric molecular material is especially strange S100 aqueous dispersion; Described plasticizer is triethyl citrate.
Wherein, described enteric coated micropill is prepared from by the supplementary material of following weight proportioning:
Antibacterial peptide 25 parts, zinc oxide 35 parts, hydroxypropyl cellulose 40 parts, especially strange S100 aqueous dispersion 40 parts, triethyl citrate 1 part, Pulvis Talci 2 parts, purified water 57 parts; Or
Antibacterial peptide 35 parts, zinc oxide 35 parts, hydroxypropyl cellulose 30 parts, especially strange S100 aqueous dispersion 40 parts, triethyl citrate 1 part, Pulvis Talci 2 parts, purified water 57 parts.
The invention provides the method preparing described enteric coated micropill, comprise the steps:
A. prepare ball core: mixed homogeneously with zinc oxide by antibacterial peptide, add binding agent soft material, soft material is made bar, shear, round as a ball, make microspheric granula, drying, obtain ball core;
B. bag enteric layer: the ball core of step a is placed in fluidized-bed coating machine, and spray into enteric coating liquid, coating completes post-drying, obtains enteric coated micropill.
Wherein, in step a, binding agent selects concentration to be the hydroxypropyl cellulose aqueous solution of 1.5%v/v, soft material is extruded under rotating speed is the condition of 50r/min, make bar, then carry out shearing and round as a ball by the spheronizator that blower fan frequency is 25Hz, the rotating speed of spheronizator is 300-500r/min, used time 30s, the fluid bed that the microspheric granula made is placed in 60 DEG C is dried to water content and is less than 5%;
In step b, under constant temperature 33-37 DEG C condition, carry out coating to ball core, enteric coating liquid is made up of especially strange S100 aqueous dispersion, triethyl citrate, Pulvis Talci and purified water, and the granularity of the enteric coated micropill made is 40 orders.
The invention provides the purposes of described enteric coated micropill in the medicine of preparation treatment piglet diarrhea.
The invention provides the purposes of described enteric coated micropill in the medicine of preparation promotion weight gain of piglets.
Present invention also offers a kind of preparation for the treatment of piglet diarrhea, it contains described enteric coated micropill.
Wherein, described preparation is tablet, capsule, granule.
Enteric coated micropill steady quality prepared by the present invention, disintegrate stripping property is good, not only solves antibacterial peptide and zinc oxide instability in gastric acid, easily by stomach acids destroy, cause the problem that antibacterial efficacy reduces, and decrease the consumption of antibacterial peptide and zinc oxide, avoid, because of excess intake zinc ion, causing poisoning.Enteric coated micropill of the present invention has the significant effect reducing diarrhea of weaned piglets rate, makes piglet diarrhea rate be reduced to 1/9 of non-administration piglet diarrhea rate.Enteric coated micropill of the present invention is the medicine that veterinary clinic treatment piglet diarrhea provides a kind of efficient, inexpensive, easy, safe, non-stimulated, noresidue, has wide market prospect.
Below by way of detailed description of the invention, the present invention is described in further detail, but do not limit the present invention, the various change that those skilled in the art make according to the present invention and replacement, only otherwise depart from spirit of the present invention, all should belong to the scope of claims of the present invention.
Detailed description of the invention
The preparation of embodiment 1 enteric coated micropill of the present invention
Supplementary material is taken by following weight proportion:
The consumption of supplementary material in ball core:
Antibacterial peptide 20g
Zinc oxide 20g
Hydroxypropyl cellulose 60g
In enteric layer, the consumption of adjuvant:
Preparation method is as follows:
A. ball core is prepared: mixed homogeneously with zinc oxide by antibacterial peptide, add the hydroxypropyl cellulose aqueous solution soft material that concentration is 1.5%v/v, be extrude under the condition of 50r/min at rotating speed by soft material, make bar, then carry out shearing and round as a ball by the spheronizator that blower fan frequency is 25Hz, make microspheric granula, the rotating speed of spheronizator is 300-500r/min, used time 30s, the fluid bed oven dry microspheric granula prepared being placed in 60 DEG C is less than 5% to water content, obtains ball core;
B. bag enteric layer: the ball core of step a is placed in fluidized-bed coating machine, constant temperature is to 33-37 DEG C, and spray into the enteric coating liquid be made up of especially strange S100 aqueous dispersion, triethyl citrate, Pulvis Talci and purified water, coating completes post-drying, obtain enteric coated micropill, micropill granularity is 40 orders.Wherein the ratio of ball core and coatings is 8:2.
The preparation of embodiment 2 enteric coated micropill of the present invention
Supplementary material is taken by following weight proportion:
The consumption of supplementary material in ball core:
Antibacterial peptide 40g
Zinc oxide 20g
Hydroxypropyl cellulose 40g
In enteric layer, the consumption of adjuvant:
Preparation method is as follows:
A. ball core is prepared: mixed homogeneously with zinc oxide by antibacterial peptide, add the hydroxypropyl cellulose aqueous solution soft material that concentration is 1.5%v/v, be extrude under the condition of 50r/min at rotating speed by soft material, make bar, then carry out shearing and round as a ball by the spheronizator that blower fan frequency is 25Hz, make microspheric granula, the rotating speed of spheronizator is 300-500r/min, used time 30s, the fluid bed oven dry microspheric granula prepared being placed in 60 DEG C is less than 5% to water content, obtains ball core;
B. bag enteric layer: the ball core of step a is placed in fluidized-bed coating machine, constant temperature is to 33-37 DEG C, and spray into the enteric coating liquid be made up of especially strange S100 aqueous dispersion, triethyl citrate, Pulvis Talci and purified water, coating completes post-drying, obtain enteric coated micropill, micropill granularity is 40 orders.Wherein the ratio of ball core and coatings is 8:2.
The preparation of embodiment 3 enteric coated micropill of the present invention
Supplementary material is taken by following weight proportion:
The consumption of supplementary material in ball core:
Antibacterial peptide 25g
Zinc oxide 35g
Hydroxypropyl cellulose 40g
In enteric layer, the consumption of adjuvant:
Preparation method is as follows:
A. ball core is prepared: mixed homogeneously with zinc oxide by antibacterial peptide, add the hydroxypropyl cellulose aqueous solution soft material that concentration is 1.5%v/v, be extrude under the condition of 50r/min at rotating speed by soft material, make bar, then carry out shearing and round as a ball by the spheronizator that blower fan frequency is 25Hz, make microspheric granula, the rotating speed of spheronizator is 300-500r/min, used time 30s, the fluid bed oven dry microspheric granula prepared being placed in 60 DEG C is less than 5% to water content, obtains ball core;
B. bag enteric layer: the ball core of step a is placed in fluidized-bed coating machine, constant temperature is to 33-37 DEG C, and spray into the enteric coating liquid be made up of especially strange S100 aqueous dispersion, triethyl citrate, Pulvis Talci and purified water, coating completes post-drying, obtain enteric coated micropill, micropill granularity is 40 orders.Wherein the ratio of ball core and coatings is 8:2.
The preparation of embodiment 4 enteric coated micropill of the present invention
Supplementary material is taken by following weight proportion:
The consumption of supplementary material in ball core:
Antibacterial peptide 35g
Zinc oxide 35g
Hydroxypropyl cellulose 30g
In enteric layer, the consumption of adjuvant:
Preparation method is as follows:
A. ball core is prepared: mixed homogeneously with zinc oxide by antibacterial peptide, add the hydroxypropyl cellulose aqueous solution soft material that concentration is 1.5%v/v, be extrude under the condition of 50r/min at rotating speed by soft material, make bar, then carry out shearing and round as a ball by the spheronizator that blower fan frequency is 25Hz, make microspheric granula, the rotating speed of spheronizator is 300-500r/min, used time 30s, the fluid bed oven dry microspheric granula prepared being placed in 60 DEG C is less than 5% to water content, obtains ball core;
B. bag enteric layer: the ball core of step a is placed in fluidized-bed coating machine, constant temperature is to 33-37 DEG C, and spray into the enteric coating liquid be made up of especially strange S100 aqueous dispersion, triethyl citrate, Pulvis Talci and purified water, coating completes post-drying, obtain enteric coated micropill, micropill granularity is 40 orders.Wherein the ratio of ball core and coatings is 8:2.
The preparation of embodiment 5 enteric coated micropill of the present invention
Supplementary material is taken by following weight proportion:
The consumption of supplementary material in ball core:
Antibacterial peptide 20g
Zinc oxide 40g
Hydroxypropyl cellulose 40g
In enteric layer, the consumption of adjuvant:
Preparation method is as follows:
A. ball core is prepared: mixed homogeneously with zinc oxide by antibacterial peptide, add the hydroxypropyl cellulose aqueous solution soft material that concentration is 1.5%v/v, be extrude under the condition of 50r/min at rotating speed by soft material, make bar, then carry out shearing and round as a ball by the spheronizator that blower fan frequency is 25Hz, make microspheric granula, the rotating speed of spheronizator is 300-500r/min, used time 30s, the fluid bed oven dry microspheric granula prepared being placed in 60 DEG C is less than 5% to water content, obtains ball core;
B. bag enteric layer: the ball core of step a is placed in fluidized-bed coating machine, constant temperature is to 33-37 DEG C, and spray into the enteric coating liquid be made up of especially strange S100 aqueous dispersion, triethyl citrate, Pulvis Talci and purified water, coating completes post-drying, obtain enteric coated micropill, micropill granularity is 40 orders.Wherein the ratio of ball core and coatings is 8:2.
The preparation of embodiment 6 enteric coated micropill of the present invention
Supplementary material is taken by following weight proportion:
The consumption of supplementary material in ball core:
Antibacterial peptide 20g
Zinc oxide 40g
Hydroxypropyl cellulose 40g
In enteric layer, the consumption of adjuvant:
Preparation method is as follows:
A. ball core is prepared: mixed homogeneously with zinc oxide by antibacterial peptide, add the hydroxypropyl cellulose aqueous solution soft material that concentration is 1.5%v/v, be extrude under the condition of 50r/min at rotating speed by soft material, make bar, then carry out shearing and round as a ball by the spheronizator that blower fan frequency is 25Hz, make microspheric granula, the rotating speed of spheronizator is 300-500r/min, used time 30s, the fluid bed oven dry microspheric granula prepared being placed in 60 DEG C is less than 5% to water content, obtains ball core;
B. bag enteric layer: the ball core of step a is placed in fluidized-bed coating machine, constant temperature is to 33-37 DEG C, and spray into the enteric coating liquid be made up of especially strange S100 aqueous dispersion, triethyl citrate, Pulvis Talci and purified water, coating completes post-drying, obtain enteric coated micropill, micropill granularity is 40 orders.Wherein the ratio of ball core and coatings is 9:1.
The preparation of embodiment 7 enteric coated micropill of the present invention
Supplementary material is taken by following weight proportion:
The consumption of supplementary material in ball core:
Antibacterial peptide 20g
Zinc oxide 40g
Hydroxypropyl cellulose 40g
In enteric layer, the consumption of adjuvant:
Preparation method is as follows:
A. ball core is prepared: mixed homogeneously with zinc oxide by antibacterial peptide, add the hydroxypropyl cellulose aqueous solution soft material that concentration is 1.5%v/v, be extrude under the condition of 50r/min at rotating speed by soft material, make bar, then carry out shearing and round as a ball by the spheronizator that blower fan frequency is 25Hz, make microspheric granula, the rotating speed of spheronizator is 300-500r/min, used time 30s, the fluid bed oven dry microspheric granula prepared being placed in 60 DEG C is less than 5% to water content, obtains ball core;
B. bag enteric layer: the ball core of step a is placed in fluidized-bed coating machine, constant temperature is to 33-37 DEG C, and spray into the enteric coating liquid be made up of especially strange S100 aqueous dispersion, triethyl citrate, Pulvis Talci and purified water, coating completes post-drying, obtain enteric coated micropill, micropill granularity is 40 orders.Wherein the ratio of ball core and coatings is 7:3.
Beneficial effect of the present invention is proved below by way of specific experiment.
Experimental example 1 zinc oxide vitro release measures
1. laboratory sample
Enteric coated micropill of the present invention, prepares according to embodiment 4.
2. experimental technique
Respectively prepare pH be 1.2 simulated gastric fluid and pH be that the simulated intestinal fluid 750ml of 7.8 is in the stripping rotor of disintegration tester, treat that dissolution medium temperature constant is at 37 degrees Celsius, get each 3g of micropill, that puts into disintegration tester turns in basket, start stripping analyzer, after 40min, taking-up turns basket, get filtrate 25ml in triangular flask, add the alcoholic solution 1 of 0.025% C.I. 13020., drip ammonia solution to the micro-yellow of solution, add water 25ml, ammonia, ammonium chloride buffer (pH10.0) 10ml and chromium black T indicator a little, with Calcium Disodium Versenate volumetric solution (0.05mol/L) titration, pure blue is changed into by purple to solution.The Calcium Disodium Versenate volumetric solution (0.05mol/L) of every 1ml is equivalent to the ZnO of 4.069mg.
3. experimental result, in table 1.
Table 1
| Project | EDTA-2Na(ml) | ZnO(mg) | ZnO ratio (%) |
| Simulated gastric fluid | 0.61 | 75 | 6.87 |
| Simulated intestinal fluid | 8.03 | 980 | 89.8 |
4. experiment conclusion
Result show: enteric coated micropill of the present invention in simulated intestinal fluid dissolution close to 90%, wrap effective, steady quality, disintegrate stripping property is good, in addition enteric coated micropill has the character that can discharge medicine in intestinal fixed point, make medicine local concentration reach anti-diarrhea effect, not only solve antibacterial peptide and zinc oxide instability in gastric acid, easily by stomach acids destroy, cause the problem that antibacterial efficacy reduces, and decrease the consumption of antibacterial peptide and zinc oxide, avoid, because of excess intake zinc ion, causing poisoning.
The impact that experimental example 2 enteric coated micropill of the present invention increases weight on ablactational baby pig and suffers from diarrhoea
1. laboratory sample
Enteric coated micropill of the present invention (sample 1 is prepared according to embodiment 1, sample 2 is prepared according to embodiment 2, sample 3 is prepared according to embodiment 3, sample 4 prepare according to embodiment 4), bacitracin, zinc oxide, wherein bacitracin and zinc oxide use raw material to add suitable adjuvant by the present invention to make powder.
2. laboratory animal grouping and administration
Choose in pig farm, Qionglai by ablactational baby pig 140, be divided into 7 groups at random, often organize 20, be respectively normal group, bacitracin group (dosage: 300g/ ton), zinc oxide group (dosage: 300g/ ton), sample 1-4 group (dosage: 300g/ ton).Test period is 7 days, with the weight of administration ablactational baby pig after seven days before the weighed administration of difference, and records diarrhoea situation.
3. experimental result, in table 2.
Table 2
4. experiment conclusion
Result shows: enteric coated micropill of the present invention makes the diarrhea rate of piglet reduce 40%, show that enteric coated micropill of the present invention effectively can treat piglet diarrhea, simultaneously, enteric coated micropill of the present invention makes piglet average weight gain 3.5kg, shows that enteric coated micropill of the present invention also has the effect of the weight significantly increasing ablactational baby pig.
To sum up, enteric coated micropill of the present invention not only solves antibacterial peptide and zinc oxide is unstable in gastric acid, easily by stomach acids destroy, causes the problem that antibacterial efficacy reduces, and decreases the consumption of antibacterial peptide and zinc oxide, avoid, because of excess intake zinc ion, causing poisoning.Enteric coated micropill of the present invention has the significant effect reducing diarrhea of weaned piglets rate and increase ablactational baby pig weight, for veterinary clinic treatment piglet diarrhea provides a kind of medicine of efficient, inexpensive, easy, safe, non-stimulated, noresidue, there is wide market prospect.
Claims (11)
1. treat the enteric coated micropill of piglet diarrhea for one kind, it is characterized in that: it is active component by antibacterial peptide and zinc oxide, add the enteric coated micropill that pharmaceutically acceptable adjuvant is prepared from, described enteric coated micropill comprises ball core and enteric layer, and the percentage by weight of the two is: ball core 70%-90%, enteric layer 10%-30%.
2. enteric coated micropill according to claim 1, is characterized in that: described ball core and the percentage by weight of enteric layer are:
Ball core 80%, enteric layer 20%.
3. enteric coated micropill according to claim 1 and 2, is characterized in that: described ball core is made up of the supplementary material of following percentage by weight:
Antibacterial peptide 20%-40%
Zinc oxide 20%-40%
Binding agent 20%-60%;
Described enteric layer is made up of the adjuvant of following percentage by weight:
4. enteric coated micropill according to claim 3, is characterized in that: described binding agent is hydroxypropyl cellulose; Described enteric molecular material is especially strange S100 aqueous dispersion; Described plasticizer is triethyl citrate.
5. enteric coated micropill according to claim 4, is characterized in that: it is prepared from by the supplementary material of following weight proportioning:
Antibacterial peptide 25 parts, zinc oxide 35 parts, hydroxypropyl cellulose 40 parts, especially strange S100 aqueous dispersion 40 parts, triethyl citrate 1 part, Pulvis Talci 2 parts, purified water 57 parts; Or
Antibacterial peptide 35 parts, zinc oxide 35 parts, hydroxypropyl cellulose 30 parts, especially strange S100 aqueous dispersion 40 parts, triethyl citrate 1 part, Pulvis Talci 2 parts, purified water 57 parts.
6. prepare the method for the enteric coated micropill described in claim 1-5 any one, it is characterized in that: comprise the steps:
A. prepare ball core: mixed homogeneously with zinc oxide by antibacterial peptide, add binding agent soft material, soft material is made bar, shear, round as a ball, make microspheric granula, drying, obtain ball core;
B. bag enteric layer: the ball core of step a is placed in fluidized-bed coating machine, and spray into enteric coating liquid, coating completes post-drying, obtains enteric coated micropill.
7. method according to claim 6, is characterized in that:
In step a, binding agent selects concentration to be the hydroxypropyl cellulose aqueous solution of 1.5%v/v, soft material is extruded under rotating speed is the condition of 50r/min, make bar, the spheronizator being 25Hz by blower fan frequency again carries out shearing and round as a ball, the rotating speed of spheronizator is 300-500r/min, used time 30s, and the fluid bed that the microspheric granula made is placed in 60 DEG C is dried to water content and is less than 5%;
In step b, under constant temperature 33-37 DEG C condition, carry out coating to ball core, enteric coating liquid is made up of especially strange S100 aqueous dispersion, triethyl citrate, Pulvis Talci and purified water, and the granularity of the enteric coated micropill made is 40 orders.
8. the purposes of the enteric coated micropill described in claim 1-5 any one in the medicine of preparation treatment piglet diarrhea.
9. the enteric coated micropill described in claim 1-5 any one promotes the purposes in the medicine of weight gain of piglets in preparation.
10. treat a preparation for piglet diarrhea, it contains the enteric coated micropill described in claim 1-4 any one.
11. preparations according to claim 10, is characterized in that: described preparation is tablet, capsule or granule.
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| CN105707440A (en) * | 2016-04-25 | 2016-06-29 | 四川定锌丸饲料科技有限公司 | Feed additive coating agent as well as preparation method and application thereof |
| CN109276561A (en) * | 2018-11-12 | 2019-01-29 | 浙江诚缘生物科技有限公司 | A kind of nano zine oxide enteric-coated micro-pill and preparation method thereof |
| CN111557930A (en) * | 2020-05-27 | 2020-08-21 | 瑞普（天津）生物药业有限公司 | Fluoroquinolone antibiotic capsule for pets and preparation method thereof |
| CN111557930B (en) * | 2020-05-27 | 2022-08-05 | 瑞普（天津）生物药业有限公司 | Fluoroquinolone antibiotic capsule for pets and preparation method thereof |
| CN116159037A (en) * | 2023-04-25 | 2023-05-26 | 四川省川龙动科药业有限公司 | Targeted pellet composition for preventing and treating piglet colitis and preparation method thereof |
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