CN101803684A - Enteric zinc oxide and method for preparing same - Google Patents
Enteric zinc oxide and method for preparing same Download PDFInfo
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- CN101803684A CN101803684A CN 201010148547 CN201010148547A CN101803684A CN 101803684 A CN101803684 A CN 101803684A CN 201010148547 CN201010148547 CN 201010148547 CN 201010148547 A CN201010148547 A CN 201010148547A CN 101803684 A CN101803684 A CN 101803684A
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- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 title claims abstract description 156
- 239000011787 zinc oxide Substances 0.000 title claims abstract description 92
- 238000000034 method Methods 0.000 title abstract description 4
- 239000000463 material Substances 0.000 claims abstract description 24
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 68
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims description 14
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 10
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 10
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 10
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 10
- 239000002994 raw material Substances 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 9
- 239000004925 Acrylic resin Substances 0.000 claims description 7
- 229920000178 Acrylic resin Polymers 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 7
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims description 7
- 238000005303 weighing Methods 0.000 claims description 6
- 230000003179 granulation Effects 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 3
- 235000012343 cottonseed oil Nutrition 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 abstract description 11
- 206010012735 Diarrhoea Diseases 0.000 abstract description 7
- 241000894006 Bacteria Species 0.000 abstract description 4
- 238000006386 neutralization reaction Methods 0.000 abstract description 3
- 239000003674 animal food additive Substances 0.000 abstract description 2
- 239000002702 enteric coating Substances 0.000 abstract description 2
- 238000009505 enteric coating Methods 0.000 abstract description 2
- 230000002401 inhibitory effect Effects 0.000 abstract description 2
- 210000004211 gastric acid Anatomy 0.000 abstract 1
- 235000014692 zinc oxide Nutrition 0.000 description 65
- 235000016804 zinc Nutrition 0.000 description 41
- 239000011701 zinc Substances 0.000 description 40
- 229910052725 zinc Inorganic materials 0.000 description 40
- 238000007792 addition Methods 0.000 description 10
- 230000002354 daily effect Effects 0.000 description 9
- 230000003647 oxidation Effects 0.000 description 9
- 238000007254 oxidation reaction Methods 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 230000002265 prevention Effects 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 210000004051 gastric juice Anatomy 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000002427 irreversible effect Effects 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000002689 soil Substances 0.000 description 3
- RNWHGQJWIACOKP-UHFFFAOYSA-N zinc;oxygen(2-) Chemical group [O-2].[Zn+2] RNWHGQJWIACOKP-UHFFFAOYSA-N 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 2
- 229960001763 zinc sulfate Drugs 0.000 description 2
- 229910000368 zinc sulfate Inorganic materials 0.000 description 2
- 229920000832 Cutin Polymers 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 238000003975 animal breeding Methods 0.000 description 1
- 239000010828 animal waste Substances 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000002942 anti-growth Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 235000014590 basal diet Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229940038879 chelated zinc Drugs 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000009285 membrane fouling Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- -1 polysaccharide zinc complexes Chemical class 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 150000003752 zinc compounds Chemical class 0.000 description 1
- UOXSXMSTSYWNMH-UHFFFAOYSA-L zinc;2-aminoacetate Chemical compound [Zn+2].NCC([O-])=O.NCC([O-])=O UOXSXMSTSYWNMH-UHFFFAOYSA-L 0.000 description 1
Landscapes
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses enteric zinc oxide coated by the enteric coating material and a method for preparing the same, belonging to the field of the feed additive. The enteric zinc oxide can effectively prevent the neutralization of the gastric acid of the animal and meet the physiological need of the animal through the enteric zinc oxide of 1000mg/kg or less is added. In addition, the enteric zinc oxide has the efficacy of inhibiting harmful bacteria and preventing the animal from suffering from the diarrhea.
Description
Technical field
The present invention relates to feed additive field, relate in particular to a kind of enteric zinc oxide and preparation method thereof.
Background technology
Zinc is the indispensable element of animal, and biochemical functions is called as " biological element " owing to it has widely in animal body.Zinc is the composition of plurality of enzymes, and it participates in the synthetic of body protein, the metabolism of nutriments such as fat, carbohydrate and vitamin, and the generation of skeleton development and cutin also needs the participation of zinc; Zinc can also strengthen immunity of organisms, improves anti-infection ability and promotes wound healing.When lacking zinc, the disorder of body metabolism be can cause, the growth, immunity of animal etc. influenced.
At present, the kind of the zinc of extensive use has two kinds of inorganic zinc and organic zincs in the animal-breeding process.Inorganic zinc mainly comprises: zinc oxide, zinc sulfate and basic zinc chloride or the like, adding inorganic zinc in feed is a comparatively cheap additional zinc element approach, but body internal absorption factor and bioavailability are lower, and easy and other mineral matter elements generation antagonisms.Organic zinc mainly comprises: complexing zinc, organic chelated zinc, zinc albuminate and polysaccharide zinc complexes etc. are several.With respect to inorganic zinc, organic zinc is as the zinc source, and low dosage uses the additional zinc effect that just can reach the high dose inorganic zinc.
In various zinc source, have only zinc oxide that the young animal is not only had the effectiveness of additional zinc element, but also have pharmacological action concurrently, inhibited to pathogenic entero becteria, reach the purpose that prevention and treatment are suffered from diarrhoea.But, zinc oxide body internal absorption factor and bioavailability extremely low (about below 10%), and be subjected to the influence of hydrochloric acid in gastric juice neutralization, therefore must the high level interpolation just can reach obvious effects.Studies have shown that, in feed, add 2500-3500mg/kg zinc oxide, reduce " weaning syndrome " influence weanling pig for promoting weanling pig growth and prevention diarrhoea to have quite significantly effect.In a word, at present, in pig industry, use high level of oxidation zinc to be mainly used in the baby pig feedstuff at wean initial stage, play anti-diarrhoea and growth promoting function; When using low dosage zinc, normally with zinc sulfate or zinc-amino acid chelate, main purpose provides the required zinc element of growth.
Use the harm of high level of oxidation zinc to be fully realized by people at present.High level of oxidation zinc can cause that growth causes negative effect to zinc poisoning to the piglet late growing stage.Secondly, add the high-level zinc that surpasses 20～30 times of normal needs in the daily ration, must break the balance of original various elements, unfavorable to the absorption of copper, iron, cause iron, copper secondary deficiency, anaemia appears.In a single day moreover, if stop to add high-level zinc, change daily ration, the grice diarrhoea phenomenon can take place again, reason may be that zinc oxide all plays inhibitory action to harmful bacterium in the enteron aisle and beneficial bacterium.
Common zinc oxide, the animal organism utilization rate is extremely low, only with utilize wherein about 10%, most of with defecate in environment.(2004) such as guilt rubine studies show that, after the high dose zinc oxide (3000mg/kg) of feeding was digested and assimilated by the pig body, its, zinc discharge rate was 33 times of basal diet group of feeding every day.Therefore, add high level of oxidation zinc and can cause the wasting of resources and metal residual, and cause the irreversible pollution of environment.
No. 1224 bulletin " the feed addictive safe handling standard " regulation of The Ministry of Agriculture of the People's Republic of China, MOA's issue, behind the weaned piglet in preceding 2 all mixed feeds the addition of the zinc of zinc oxide form be no more than 2250mg/kg, this high zinc daily ration can only be used to the to wean piglet in preceding 2 weeks of back.As seen, country's further restriction and standard zinc oxide use (annotate: having abrogated the middle weanling pig preceding 2 all daily ration zinc oxide additions of agricultural industry criteria " NY929-2005 " is to be no more than 3000mg/kg).The scientific research personnel has recognized the side effect of using high level of oxidation zinc to be brought, carried out the research and development of efficient zinc compound earlier, feed weanling pig with in can substitute or reduce and use common zinc oxide in the diet, and reach the prevention diarrhoea effect identical with high level of oxidation zinc.Nano zine oxide is such product, there are some researches show, under the 375mg/kg addition, remarkable for growth performance that promotes weanling pig and prevention diarrhoea effect, can substitute high level of oxidation zinc (3000mg/kg), be a kind of desirable zinc source, but that is that all right is ripe for the nano zine oxide technology, also needs more deep research.
Summary of the invention
For solving the problem of using the high level of oxidation zinc feed to bring in the above-mentioned breeding process, it is a kind of through the processed enteric zinc oxide of enteric-coating material bag that the object of the invention is to provide, can avoid the neutralization of animal hydrochloric acid in gastric juice effectively, even under the situation of low-level interpolation (being no more than 1000mg/kg), both can satisfy the physiological requirements of animal, can also reach the pharmacology effectiveness that suppresses harmful bacterium, prevention diarrhea.
Second purpose of the present invention is to provide a kind of preparation method of enteric zinc oxide.
For achieving the above object, the present invention adopts following technical scheme:
A kind of enteric zinc oxide is made up of granular zinc oxide and enteric solubility material,
Admittedly the weight ratio that contains thing in described granular zinc oxide and the enteric solubility material is 1: 0.05-0.15;
Described granular zinc oxide comprises powdery zinc oxide and microcrystalline cellulose, and the weight ratio of the two is 0.65-0.75: 0.25-0.35;
Described enteric solubility material is made up of following raw material, and each raw material weight percentage is:
Acrylic resin: 4%-8%;
Talcum powder: 4%-8%;
Diethyl phthalate: 2%-4%;
95% alcohol: 80%-90%.
Admittedly the weight ratio that contains thing in described granular zinc oxide and the enteric solubility material is 1: 0.1.
The weight ratio of described powdery zinc oxide and microcrystalline cellulose is 0.7: 0.3.
Described granular zinc oxide also comprises the polyethylene glycol aqueous solution.
The concentration of the described polyethylene glycol aqueous solution is 2%-3%.
Described enteric solubility material is made up of following raw material, and each raw material weight percentage is:
Acrylic resin: 4%;
Talcum powder: 4%;
Diethyl phthalate: 2%;
95% alcohol: 90%.
A kind of preparation method of enteric zinc oxide may further comprise the steps:
1) prepares granular zinc oxide, granular zinc oxide is prepared material by mixing than row, put into granulator, start the granulation program, obtain granular zinc oxide;
2) the granular zinc oxide Cotton seeds that obtains of step 1), above-mentioned enteric material is put into the dressing machine by after mixing than row, adds granular zinc oxide, starts dressing machine program, obtains enteric zinc oxide.
Described step 1) is specially: according to weight ratio is that 0.65-0.75: 0.25-0.35 takes by weighing powdery zinc oxide and microcrystalline cellulose; taking by weighing weight is the polyethylene glycol aqueous solution of powdery zinc oxide and microcrystalline cellulose gross weight 60-65%; the three is mixed; put into granulator; start the granulation program, obtain granular zinc oxide.
Enteric zinc oxide of the present invention, the characteristic of utilizing the segmentation of enteric capsulating material to discharge can effectively protect zinc oxide not neutralized by hydrochloric acid in gastric juice, and capsulating material can decompose when arriving enteron aisle, and zinc oxide discharges naturally; Enteric zinc oxide can replace common zinc oxide, reduces the use of zinc oxide, can fundamentally reduce the interpolation level of zinc oxide in the weanling pig daily ration, reduces the irreversible pollution of zinc residual in the pig ight soil to soil.
The specific embodiment
1 one kinds of enteric zinc oxides of embodiment and preparation method thereof
Enteric zinc oxide is made up of granular zinc oxide and enteric solubility material,
Admittedly the weight ratio that contains thing in described granular zinc oxide and the enteric solubility material is 1: 0.1;
Described granular zinc oxide is made up of powdery zinc oxide and microcrystalline cellulose, and the weight of the two is respectively 70kg and 30kg;
Described enteric solubility material is made up of following raw material, and each raw material weight percentage is:
Acrylic resin: 4kg;
Talcum powder: 4kg;
Diethyl phthalate: 2kg;
95% alcohol: 90kg.
The preparation method of above-mentioned enteric zinc oxide may further comprise the steps:
1) prepares granular zinc oxide: take by weighing zinc oxide 70kg, microcrystalline cellulose 30kg, 3% polyethylene glycol aqueous solution 60kg, drop into HWMG200 type efficient wet mixer-granulator hopper, the low temperature extruder is at the 40rpm rotating speed, extruded material under the 0.42mm aperture, again by the round as a ball dish diameter spheronizator that is 700mm with the round as a ball oxidisability particle of 300r/min rotating speed, after production finishes, metering, packing, the granular zinc oxide of every packing 100kg;
2) preparation coating material: take by weighing acrylic resin 4kg, talcum powder 4kg adds diethyl phthalate 2kg, 95% alcohol 90kg; Acrylic resin is dissolved in 95% the alcohol, adds talcum powder, diethyl phthalate then, just can stir;
3) the granular zinc oxide and the step 2 that step 1) are obtained) coating material that obtains prepares by 1: 0.1 weight ratio and throws in LBF-200 eddy flow fluidized granulation dressing machine, at wind speed 30～35MHz, 50 ℃ of intake air temperatures, carry out dressing under 35 ℃ of conditions of air outlet temperature, the dressing duration be every batch 6 hours, produce finish after, metering, packing gets 110kg enteric zinc oxide finished product.
Experimental example is verified its function with the embodiment 1 described enteric zinc oxide weanling pig of feeding
(1) place: pig farm, Guangdong
(2) experiment combination:
Different additions according to enteric zinc oxide are provided with three experimental group:
Experimental group A:300 gram/ton (being equivalent to 300mg/kg);
Experimental group B:500 gram/ton (being equivalent to 500mg/kg);
Experimental group C:800 gram/ton (being equivalent to 800mg/kg).
Control group D is for adding common zinc oxide: addition is 2500g/ ton (being equivalent to 2500mg/kg).
(3) experimental subjects: 21 age in days weanling pigs, totally 396.According to health status, the bodily form random packet of piglet, 99 of A groups, 100 of B groups, 102 of C groups, 95 of D groups.
(4) experimental period: 14 days
(5) test data: daily ingestion amount, total augment weight, calculate daily gain and feedstuff-meat ratio.
(6) feed management: the feed formula of each group is except zinc oxide addition difference, and other compositions are unanimity.Experimental session is responsible for raising by the special messenger, and environmental condition is consistent, free choice feeding, drinking-water.Carry out routine immunization and sterilization, keep the colony house sanitation and hygiene.Observe growing state, carry out relevant record.36 ages in days carry out empty stomach and weigh.
(7) result:
Data are summed up:
Table one enteric zinc oxide is to the growth performance influence of weanling pig
| Experimental group A (enteric zinc oxide, 300 gram/tons) | Experimental group B (enteric zinc oxide, 500 gram/tons) | Experimental group C (enteric zinc oxide, 800 gram/tons) | Experimental group D (common zinc oxide, 2500 gram/tons) | |
| An experiment number | 99 | 100 | 102 | 95 |
| Beginning counterpoise (kg) | 5.92 | 6.39 | 6.47 | 6.03 |
| Finish a number | 99 | 100 | 102 | 95 |
| Finish counterpoise | 8.32 | 8.92 | 9.13 | 8.35 |
| Gross weight (kg) | 823.68 | 892 | 931.26 | 793.25 |
| Daily gain (kg) | 15.83 | 16.85 | 18.12 | 14.67 |
| Average daily feed intake (kg) | 17.29 | 18.43 | 19.23 | 16.23 |
| Feedstuff-meat ratio | 1.10 | 1.09 | 1.06 | 1.11 |
Conclusion:
1, gained to sum up is even (＜1000mg/kg) addition, the growth performance of weanling pig is still unaffected, even better than the control group that adds high level of oxidation zinc (2500mg/kg) low-level for enteric zinc oxide.Reduce by 4.5% at experimental group C (800mg/kg) feedstuff-meat ratio than control group.
2, adding different amount enteric zinc oxides also also can influence to some extent to the growth performance of weanling pig, and under the situation of addition less than 1000mg/kg, feedstuff-meat ratio reduces along with the increase of addition.
Enteric zinc oxide of the present invention has following advantage:
1) solved common zinc oxide and neutralized by hydrochloric acid in gastric juice easily, in the problem of animal intestinal biological utilisation inefficiency;
2) fundamentally reduce the addition of zinc oxide in the weanling pig feed;
3) effectively reduce the discharge amount of zinc in the animal wastes, reduce the soil irreversible membrane fouling.
Claims (8)
1. an enteric zinc oxide is made up of granular zinc oxide and enteric solubility material, it is characterized in that:
Admittedly the weight ratio that contains thing in described granular zinc oxide and the enteric solubility material is 1: 0.05-0.15;
Described granular zinc oxide comprises powdery zinc oxide and microcrystalline cellulose, and the weight ratio of the two is 0.65-0.75: 0.25-0.35;
Described enteric solubility material is made up of following raw material, and each raw material weight percentage is:
Acrylic resin: 4%-8%;
Talcum powder: 4%-8%;
Diethyl phthalate: 2%-4%;
95% alcohol: 80%-90%.
2. enteric zinc oxide according to claim 1 is characterized in that: the weight ratio that contains thing in described granular zinc oxide and the enteric solubility material admittedly is 1: 0.1.
3. enteric zinc oxide according to claim 1 is characterized in that: the weight ratio of described powdery zinc oxide and microcrystalline cellulose is 0.7: 0.3.
4. enteric zinc oxide according to claim 1 is characterized in that: described granular zinc oxide also comprises the polyethylene glycol aqueous solution.
5. enteric zinc oxide according to claim 4 is characterized in that: the concentration of the described polyethylene glycol aqueous solution is 2%-3%.
6. enteric zinc oxide according to claim 1 is characterized in that: the enteric solubility material is made up of following raw material, and each raw material weight percentage is:
Acrylic resin: 4%;
Talcum powder: 4%;
Diethyl phthalate: 2%;
95% alcohol: 90%.
7. the preparation method of an enteric zinc oxide may further comprise the steps:
1) prepares granular zinc oxide, granular zinc oxide is prepared material mix in proportion, put into granulator, start the granulation program, obtain granular zinc oxide;
2) the granular zinc oxide Cotton seeds that obtains of step 1) after above-mentioned enteric material mixes in proportion, is put into the dressing machine, adds granular zinc oxide, starts dressing machine program, obtains enteric zinc oxide.
8. the preparation method of a kind of enteric zinc oxide according to claim 7; it is characterized in that; described step 1) is specially: according to weight ratio is that 0.65-0.75: 0.25-0.35 takes by weighing powdery zinc oxide and microcrystalline cellulose; taking by weighing weight is the polyethylene glycol aqueous solution of powdery zinc oxide and microcrystalline cellulose gross weight 60-65%; the three is mixed; put into granulator, start the granulation program, obtain granular zinc oxide.
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| CN102318750A (en) * | 2011-10-08 | 2012-01-18 | 成都巨星猪业有限公司 | Coated submicron feed-grade zinc oxide and preparation method thereof |
| CN103549162A (en) * | 2013-11-02 | 2014-02-05 | 成都雪樱动物科技实业有限公司 | Novel feed additive and preparation method thereof |
| CN104546907A (en) * | 2014-12-24 | 2015-04-29 | 浙江惠嘉生物科技有限公司 | Enteric nano zinc oxide preparation and preparation method thereof |
| CN104686808A (en) * | 2015-03-26 | 2015-06-10 | 无锡正大畜禽有限公司 | 50% enteric package zinc oxide nanoparticle preparation method |
| CN105012246A (en) * | 2015-08-19 | 2015-11-04 | 湖北博华农牧科技有限公司 | Nano-zinc oxide coating process |
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| CN106260599A (en) * | 2016-08-12 | 2017-01-04 | 广汉隆达饲料有限公司 | Enteric zinc oxide micropill |
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| CN109511786A (en) * | 2019-01-04 | 2019-03-26 | 重庆威迪特药业有限责任公司 | A kind of feed addictive and preparation method thereof containing zinc oxide |
| CN112841437A (en) * | 2021-01-26 | 2021-05-28 | 沈代秀 | Enteric zinc oxide for feed and production method thereof |
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| CN101664108A (en) * | 2009-09-21 | 2010-03-10 | 中国农业大学 | Rumen protected methionine and production method thereof |
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| CN1864521A (en) * | 2005-05-17 | 2006-11-22 | 珠海天翼医药技术开发有限公司 | A method for preparing sustained-release micro-pellet feeding enzyme |
| CN101554209A (en) * | 2009-05-15 | 2009-10-14 | 冯刚 | Application of coated zinc oxide as antiseptic feed additive |
| CN101664108A (en) * | 2009-09-21 | 2010-03-10 | 中国农业大学 | Rumen protected methionine and production method thereof |
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| CN101971921A (en) * | 2010-11-12 | 2011-02-16 | 胡文锋 | Zinc-enriched inactivated lactobacillus microecological agent and preparation method thereof |
| CN101971921B (en) * | 2010-11-12 | 2013-05-08 | 胡文锋 | Zinc-enriched inactivated lactobacillus microecological agent and preparation method thereof |
| CN102318750A (en) * | 2011-10-08 | 2012-01-18 | 成都巨星猪业有限公司 | Coated submicron feed-grade zinc oxide and preparation method thereof |
| CN102318750B (en) * | 2011-10-08 | 2013-06-05 | 成都巨星农牧科技有限公司 | Coated submicron feed-grade zinc oxide and preparation method thereof |
| CN103549162A (en) * | 2013-11-02 | 2014-02-05 | 成都雪樱动物科技实业有限公司 | Novel feed additive and preparation method thereof |
| CN104546907B (en) * | 2014-12-24 | 2017-10-10 | 浙江万方生物科技有限公司 | A kind of nano oxidized zinc preparation of enteric and preparation method thereof |
| CN104546907A (en) * | 2014-12-24 | 2015-04-29 | 浙江惠嘉生物科技有限公司 | Enteric nano zinc oxide preparation and preparation method thereof |
| CN104686808A (en) * | 2015-03-26 | 2015-06-10 | 无锡正大畜禽有限公司 | 50% enteric package zinc oxide nanoparticle preparation method |
| CN105012246A (en) * | 2015-08-19 | 2015-11-04 | 湖北博华农牧科技有限公司 | Nano-zinc oxide coating process |
| CN105012246B (en) * | 2015-08-19 | 2018-04-06 | 湖北博华农牧科技有限公司 | A kind of nano zine oxide coating process |
| CN105327334A (en) * | 2015-10-20 | 2016-02-17 | 成都乾坤动物药业有限公司 | Enteric coating pellets for treating piglet diarrhea and preparation method and application thereof |
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| CN106260599A (en) * | 2016-08-12 | 2017-01-04 | 广汉隆达饲料有限公司 | Enteric zinc oxide micropill |
| CN107173598A (en) * | 2017-05-22 | 2017-09-19 | 厦门隆励工贸有限公司 | A kind of efficient anti diar rhea suckling piglet mixed feed of nonreactive and preparation method thereof |
| CN108402319A (en) * | 2018-02-27 | 2018-08-17 | 沈阳市友发实业有限公司 | A kind of pig compound premixed feed solving the problems, such as pig Huang fat meat |
| CN108402328A (en) * | 2018-02-27 | 2018-08-17 | 沈阳友发实业 | A kind of broiler chicken compound premixed feed solving the problems, such as broiler chicken Huang fat meat |
| CN109511786A (en) * | 2019-01-04 | 2019-03-26 | 重庆威迪特药业有限责任公司 | A kind of feed addictive and preparation method thereof containing zinc oxide |
| CN112841437A (en) * | 2021-01-26 | 2021-05-28 | 沈代秀 | Enteric zinc oxide for feed and production method thereof |
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