CN109511786A - A kind of feed addictive and preparation method thereof containing zinc oxide - Google Patents
A kind of feed addictive and preparation method thereof containing zinc oxide Download PDFInfo
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- CN109511786A CN109511786A CN201910007362.6A CN201910007362A CN109511786A CN 109511786 A CN109511786 A CN 109511786A CN 201910007362 A CN201910007362 A CN 201910007362A CN 109511786 A CN109511786 A CN 109511786A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
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- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
The invention discloses a kind of feed addictive and preparation method thereof containing zinc oxide.The additive includes the coating grease of the zinc oxide of 400-820 parts by weight, the water soluble disperse carrier of 100-400 parts by weight and 80-200 parts by weight, and the zinc oxide is dispersed in water soluble disperse carrier, then is coated with coating grease.When preparing the feed addictive, the water soluble disperse carrier of recipe quantity is taken, after heating for dissolving, Zinc oxide powder is added, is sufficiently stirred, is uniformly distributed therein zinc oxide, cooling pellet or particle of the preparation containing zinc oxide；The zinc oxide pellet of preparation or particle are added in coating equipment in sugar production line, the coating grease of the recipe quantity after spraying into fusing be coated to get.Feed addictive containing zinc oxide of the invention, cost of material is low, zinc oxide bearing capacity is high, it is good to cross stomach effect, intestines release is abundant.
Description
Technical field
The invention belongs to feed additive fields, and in particular to a kind of containing the feed addictive of zinc oxide and its preparation side
Method.
Background technique
The zinc oxide of molecular state has the function of inhibiting bacterial growth, fast for controlling suckling piglet generally in animal productiong
The diarrhea that fast-growing growth process is likely to occur.But directly zinc oxide addition is carried out in feed in use, it is easy to by pig stomach
Gastric acid be dissociated into the zinc of ionic state, degree of dissociation is up to 90% or more, and a large amount of zinc ions enter animal intestinal tract, lead to zinc poisoning,
And the absorption and transhipment of Reverse transcriptase other nutrients, animal metabolism of trace elements balance is destroyed, animal health is influenced.On a small quantity
The zinc oxide of molecular state does not have the effect of expected antibacterial antidiarrheal.
The method for solving the problems, such as this at present is to carry out enteric coating peridium to zinc oxide by packaging technique, it is made to cross stomach safely
To small intestine and up to being discharged after colon site again.The common enteric coating technology of feed additive field is to utilize pH value in stomach and intestines
The difference of middle pH is then disintegrated rapidly pH sensitive material using property stabilization in acidic environment is coated under the conditions of meta-alkalescence
Realize the purpose of enteric.Such as pH sensitive is used in patent CN104686808A, CN104546907A, CN101971921A
The materials such as polyacrylic resin, cellulose acetate-phthalate make enteric coating.But pH value sensitive type material composition is multiple
It is miscellaneous, there is the risk of the further gastroenteric environment of stimulation sucking pig, in addition expensive, high production cost, it is difficult in field of fodder
Realization is widely popularized and uses.In addition, there are also some patents disclose some novel coatings, such as patent CN102318750A
The composite shielding agent coated zinc oxide formed with potato starch, ethyl cellulose and magnesium stearate, however starch coating exists
It will start to be digested decomposition under the action of saliva of buccal cavity amylase, it is poor to cross stomach effect.
Summary of the invention
In view of the deficiencies of the prior art, the present invention intends to provide a kind of feed addictive containing zinc oxide.
Zinc oxide in the feed addictive is first dispersed in water-soluble solid carrier, then is coated with high-melting-point grease, raw material
At low cost, zinc oxide bearing capacity height, stomach effect is good excessively, intestines release is abundant.
It is another object of the present invention to provide the preparation methods of the feed addictive containing zinc oxide.
The technical solution adopted by the invention is as follows:
A kind of feed addictive containing zinc oxide, the water of zinc oxide, 100-400 parts by weight including 400-820 parts by weight
The coating grease of dissolubility dispersible carrier and 80-200 parts by weight, the zinc oxide are dispersed in water soluble disperse carrier, then
With coating grease coating.
Preferably, the above-mentioned feed addictive containing zinc oxide, zinc oxide, 200-350 weight including 550-700 parts by weight
The water soluble disperse carrier of part and the coating grease of 80-130 parts by weight, the zinc oxide are dispersed in water soluble disperse carrier
In, then with coating grease coating.
Preferably, the weight ratio of the above-mentioned feed addictive containing zinc oxide, the zinc oxide and water soluble disperse carrier is
1:1~5:1.
Preferably, the weight ratio of the above-mentioned feed addictive containing zinc oxide, the zinc oxide and water soluble disperse carrier is
1:1~4.7:1.
Preferably, the above-mentioned feed addictive containing zinc oxide, the fusing point of the water soluble disperse carrier are 40 DEG C~150
℃。
More preferably, the above-mentioned feed addictive containing zinc oxide, the water soluble disperse carrier are selected from solid PEG or urea.
Further preferred water soluble disperse carrier is PEG2000 or PEG1500.
Preferably, the fusing point of the above-mentioned feed addictive containing zinc oxide, the coating grease is 45 DEG C~150 DEG C.
More preferably, the above-mentioned feed addictive containing zinc oxide, the coating grease are selected from palm oil, lauric monoglyceride
Or mono fatty acid glyceride.
A kind of preparation method of the feed addictive containing zinc oxide, the water soluble disperse carrier including taking recipe quantity, heating
After dissolution, Zinc oxide powder is added, is sufficiently stirred, is uniformly distributed therein zinc oxide, cooling pellet of the preparation containing zinc oxide
Or particle；The zinc oxide pellet of preparation or particle are added in coating equipment in sugar production line, the coating grease of the recipe quantity after spraying into fusing into
Row coating.
The beneficial effects of the present invention are:
1. the grease coating of coated zinc oxide can resist the destruction of gastric acid, effective protection zinc oxide is in small intestine site with molecule
State smoothly discharges, and plays optimal therapeutic effect.
2. water-soluble solid dispersible carrier of the fusing point at 40 DEG C~150 DEG C is selected, the carrier such as PEG as zinc oxide, and
In the molten state, zinc oxide is added and is stirred mixing, zinc oxide can be made to be well dispersed in water soluble disperse carrier, improve
The dispersing uniformity of zinc oxide.After coating zinc oxide reaches small intestine, coated oil membrane is digested by enteral lipase etc.,
Pellet or particle containing zinc oxide and water soluble disperse carrier are exposed, at this point, since water soluble disperse carriers Water-soluble is good, it can
Quickly dissolution, and then quick release goes out zinc oxide fine particles, plays Antidiarrheic effect.
3. this method prepares Zinc oxide particles or pellet, have method simple, high production efficiency, production cost is low, is easy to
Realize industrialization production, prepared Zinc oxide particles or pellet good fluidity, be easy to be uniformly mixed with other feed ingredients into
Row processing.
Specific embodiment
The present invention will be further explained with reference to embodiments.
Feed addictive
Feed addictive containing zinc oxide, the water solubility of zinc oxide, 100-400 parts by weight including 400-820 parts by weight
The coating grease of dispersible carrier and 80-200 parts by weight, the zinc oxide are dispersed in water soluble disperse carrier, then with packet
Clothing grease coating.
Zinc oxide in feed addictive of the invention is to inhibit bacterial growth, anti-diarrhea effective component.In the present invention
Zinc oxide in additive can be feed grade zinc oxide, be also possible to the nanoscale or Subnano-class zinc oxide of deep processing.Cause
For the effect of water soluble disperse carrier of the present invention, the zinc oxide of any form can be made to obtain fully evenly dispersed.It is aoxidizing
In zinc additive, the content of zinc oxide is higher, illustrates that the bearing capacity of carrier and coating material is stronger, can reduce additive
Cost of material guarantees that enteron aisle zinc oxide reaches effective quantity, but when the too high levels of zinc oxide, in water soluble disperse carrier
Dispersibility reduce, grease be coated with effect it is also impacted, coating structure be more easily damaged.For above-mentioned consideration, of the invention
In feed addictive, the dosage of zinc oxide is set as 400-820 parts by weight, more preferably 550-700 parts by weight.In the prior art
Many zinc oxide contents are lower than 30%, and coating and vector contg are high, at high cost.
Water soluble disperse carrier of the invention is to be fusible water-soluble substances, preferably fusing point at solid-state, heating under room temperature
For 40 DEG C~150 DEG C of water-soluble substances.In some embodiments of the invention, water soluble disperse load is made using PEG or urea
Body, further preferred water soluble disperse carrier are PEG2000, PEG6000 or PEG1500.Select the excellent of water soluble disperse carrier
One of gesture is that first in a liquid carrier by the dispersion of solid oxidation zinc, pellet and particle after solidification are dispersed in grease again
In coating, twice dispersing, the uniformity is more preferable；The two of advantage are that water-soluble carrier is after coating grease is decomposed by lipase
It is dissolved in enteron aisle digestive juice, all zinc oxide is completely released, and is coated or carrier wraps up the amount being discharged with excrement
Extremely low, utilization rate is high, and rate of release is fast, can be rapidly reached the effective dose for inhibiting bacterial growth.From dispersion effect and
Cost consideration, water soluble disperse carrier dosage of the invention are set as 100-400 parts by weight, preferably 200-350 parts by weight.
In research process of the invention, also once using PVP, sorbierite as water soluble disperse carrier material, but due to
PVP has stronger viscosity, and when dispersible carrier as zinc oxide, mixing difficulty is larger, it is difficult to be uniformly mixed, and sample is made
Dissolution slowly, is unable to reach expected effect in water after product；It, can be preferable when sorbierite is as water soluble disperse carrier material
Containing for zinc oxide is completed, faster dissolution in water can also be realized, release zinc oxide fine particles, but it is expensive, and use
When measuring larger, there is the risk led to diarrhea.
The coating grease of invention is to be fusible oil substances at solid-state, heating under room temperature, preferably fusing point is 45 DEG C~
150 DEG C of grease.In some embodiments of the invention, palm oil, lauric monoglyceride or mono fatty acid glyceride are selected
To be coated grease.Compared with pH responsive type enteric coating, it is safe additive raw material that grease coating is at low cost.And it is formed
Coating Zinc oxide particles good fluidity, be added in feed and easily mix.It is high to be coated grease amount, cost of material will increase,
Dosage is few, and coating is imperfect, or forms relatively thin and rapid wear and be coated, and therefore, the present invention is set as 80- for grease amount is coated
200 parts by weight, preferably 80-130 parts by weight.
The present inventor also found that the weight ratio of zinc oxide and water soluble disperse carrier will affect in the course of the research
The fluency of preparation process in the two mixed process, is stirred when being greater than 5:1 for the ratio of zinc oxide and water soluble disperse carrier
Mix difficulty, it is difficult to disperse and be uniformly mixed；And when the ratio of zinc oxide and water soluble disperse carrier is less than 1:1, made of
The content of zinc oxide reduces in sample, and cost of material steeply rises, compared with presently commercially available zinc oxide product, without obvious excellent
Therefore the weight ratio of the two is set as 1:1~5:1, preferably 1:1~4.7:1 as a preferred technical solution, by gesture.
Preparation method
It takes the solid, water soluble dispersible carrier of recipe quantity, after heating for dissolving, Zinc oxide powder is added under keeping warm mode, fills
Divide stirring, be uniformly distributed therein it, then passes through misting cooling pill or extrusion spheronization pill or extrusion cooling pelletization etc.
Mode prepares pellet or particle containing zinc oxide；The zinc oxide pellet of preparation or particle are added in coating equipment in sugar production line, fusing is sprayed into
The high-melting-point coating grease of recipe quantity afterwards is coated to get that can cross the coated zinc oxide pellet of stomach.
Embodiment 1
PEG2000 200g is taken, is heated to 60 DEG C, it is made to be fused into liquid, 700g zinc oxide fine particles are added, stir rapidly
Cooling makes to solidify after mixing, is grinding to obtain the particle containing zinc oxide；The palm oil for taking 52 degree of 100g, is heated to 60 DEG C, keeps it molten
It is kept the temperature after change spare；The Zinc oxide particles of preparation are added in coating equipment in sugar production line, the palm oil for spraying into aforementioned melt is coated, i.e.,
Obtain the coated zinc oxide particle that can cross stomach.
Implement 2
PEG1500 350g is taken, is heated to 60 DEG C, it is made to be fused into liquid, 580g zinc oxide fine particles are added, stir rapidly
After mixing, zinc oxide pellet is made after centrifugal spray is cooling；The palm oil for taking 52 degree of 100g, is heated to 60 DEG C, makes its fusing
After keep the temperature it is spare；The zinc oxide pellet of preparation is added in coating equipment in sugar production line, spray into aforementioned melt palm oil be coated to get
The coated zinc oxide pellet of stomach can be crossed.
Embodiment 3
PEG6000 400g is taken, is heated to 62 DEG C, it is made to be fused into liquid, 400g zinc oxide fine particles are added, stir rapidly
After mixing, zinc oxide pellet is made after centrifugal spray is cooling；The palm oil for taking 52 degree of 200g, is heated to 60 DEG C, makes its fusing
After keep the temperature it is spare；The zinc oxide pellet of preparation is added in coating equipment in sugar production line, spray into aforementioned melt palm oil be coated to get
The coated zinc oxide pellet of stomach can be crossed.
Embodiment 4
Urea 250g is taken, is heated to 140 DEG C, it is made to be fused into liquid, 600g zinc oxide fine particles are added, stir and evenly mix rapidly
Afterwards, it squeezes out cooling pelletization and obtains Zinc oxide particles；The lauric monoglyceride for taking 120g is heated to 68 DEG C, keeps the temperature after melting it
It is spare；The Zinc oxide particles of preparation are added in coating equipment in sugar production line, the lauric monoglyceride for spraying into aforementioned melt is coated, i.e.,
Obtain the coated zinc oxide pellet that can cross stomach.
Embodiment 5
Urea 160g is taken, is heated to 135 DEG C, it is made to be fused into liquid, 740g zinc oxide fine particles are added, stir and evenly mix rapidly
Afterwards, rear cooling obtained zinc oxide pellet round as a ball while hot is squeezed out；80g mono fatty acid glyceride is taken, is heated to 60 DEG C, after melting it
It keeps the temperature spare；The Zinc oxide particles of preparation are added in coating equipment in sugar production line, the lauric monoglyceride for spraying into aforementioned melt is wrapped
Clothing is to get the coated zinc oxide pellet that can cross stomach.
Embodiment 6
Urea 100g is taken, is heated to 142 DEG C, it is made to be fused into liquid, 820g zinc oxide fine particles are added, stir and evenly mix rapidly
Afterwards, rear cooling obtained zinc oxide pellet round as a ball while hot is squeezed out；52 degree of palm oils of 80g are taken, are heated to 58 DEG C, are protected after melting it
Warm standby is used；The Zinc oxide particles of preparation are added in coating equipment in sugar production line, spray into aforementioned melt 52 degree of palm oils be coated to get
The coated zinc oxide pellet of stomach can be crossed.
Test example crosses stomach and intestines slaking test
Stomach rate measurement: the sample of Example 1~6 is crossed, every group 6 parts, every part of 2g, is added in the dissolution basket of dissolution rate instrument,
The dissolution determination in simulation hydrochloric acid is carried out, selected dissolution medium is the hydrochloric acid solution of 900ml pH 1.0, and revolving speed is per minute
100 turns, temperature is 37 DEG C, after 2 hours, takes 10ml solution to filter, according under 5.5.2 in standard HG/T 2792-2011
EDTA titration measuring zinc ion content calculates under the conditions of 1.0 pH, the average percentage of the 2 hours zinc released
(%), and then stomach rate (%) was calculated, it the results are shown in Table 1.Wherein Zn content in the total zinc content=example weight × sample of sample；Acid
Zinc concentration × dissolution medium the volume for the total amount of the zinc of middle release=measure.
The measurement of disintegration rate in simulated intestinal fluid: every group 6 parts, every part of 2g, dissolution rate instrument is added in the sample of Example 1~6
Dissolution basket in, dissolution basket aperture be 0.125mm, carry out simulated intestinal fluid in disintegration measurement, selected dissolution medium be 900ml
Simulated intestinal fluid, temperature are 37 DEG C, and revolving speed is 100 turns per minute, after half an hour, take out dissolution basket, have seen whether not to be disintegrated
Zinc oxide pellet, if any claiming its weight after drying.It calculates in simulated intestinal fluid, the average disintegration rate of zinc oxide sample, ties
Fruit is shown in Table 2.
Simulated intestinal fluid preparation method: taking potassium dihydrogen phosphate 6.8g, and water 500mL is added to make to dissolve, with 0.1mol/L sodium hydroxide
Solution adjusts pH value to 6.8, takes pancreatin 10g, appropriate amount of water is added to make to dissolve, after 2 liquid are mixed, be diluted with water to 1000mL to obtain the final product.
Table 1 crosses stomach rate measurement result
Disintegration rate measurement result in 2 simulated intestinal fluid of table
| Embodiment number | Sample total amount (g) | The sample average amount (g) of dissolution basket is not crossed | Disintegration rate (%) |
| 1 | 2.00 | 0.06 | 97.2 |
| 2 | 2.00 | 0.05 | 97.5 |
| 3 | 2.00 | 0.00 | 100.0 |
| 4 | 2.00 | 0.04 | 98.0 |
| 5 | 2.00 | 0.00 | 100.0 |
| 6 | 2.00 | 0.07 | 96.5 |
The results show that sample prepared by the present invention preferable can cross stomach, crosses stomach rate and reach 95% or more, and can be in simulation intestines
It is preferably discharged in liquid.
Claims (9)
1. a kind of feed addictive containing zinc oxide, which is characterized in that zinc oxide, 100-400 weight including 400-820 parts by weight
The water soluble disperse carrier of part and the coating grease of 80-200 parts by weight are measured, the zinc oxide is dispersed in water soluble disperse load
In body, then with coating grease coating.
2. the feed addictive according to claim 1 containing zinc oxide, which is characterized in that including 550-700 parts by weight
The coating grease of zinc oxide, the water soluble disperse carrier of 200-350 parts by weight and 80-130 parts by weight, the zinc oxide uniformly divide
It is dispersed in water soluble disperse carrier, then is coated with coating grease.
3. the feed addictive according to claim 1 containing zinc oxide, which is characterized in that the zinc oxide and water-soluble point
The weight ratio for dissipating carrier is 1:1~5:1.
4. the feed addictive according to claim 1 containing zinc oxide, which is characterized in that the zinc oxide and water-soluble point
The weight ratio for dissipating carrier is 1:1~4.7:1.
5. the feed addictive containing zinc oxide described in any one according to claim 1~4, which is characterized in that described water-soluble
Property dispersible carrier fusing point be 40 DEG C~150 DEG C.
6. the feed addictive containing zinc oxide described in any one according to claim 1~4, which is characterized in that described water-soluble
Property dispersible carrier be selected from solid PEG or urea.
7. the feed addictive containing zinc oxide described in any one according to claim 1~4, which is characterized in that the coating
The fusing point of grease is 45 DEG C~150 DEG C.
8. the feed addictive according to claim 7 containing zinc oxide, which is characterized in that the coating grease is selected from palm
Oil, lauric monoglyceride or mono fatty acid glyceride and its derivative.
9. a kind of preparation method of the feed addictive containing zinc oxide as described in claim 1~8 any one, feature exist
After, the water soluble disperse carrier including taking recipe quantity, heating for dissolving, Zinc oxide powder is added, is sufficiently stirred, keeps zinc oxide equal
It is even to be dispersed therein, cooling pellet or particle of the preparation containing zinc oxide；Coating is added in the zinc oxide pellet of preparation or particle to set
In standby, the coating grease of the recipe quantity after spraying into fusing is coated.
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| CN201910007362.6A CN109511786A (en) | 2019-01-04 | 2019-01-04 | A kind of feed addictive and preparation method thereof containing zinc oxide |
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| CN110354139A (en) * | 2019-08-15 | 2019-10-22 | 武汉轻工大学 | A kind of composition of porcine epidemic diarrhea resisting virus infection and its application |
| CN112262926A (en) * | 2020-11-03 | 2021-01-26 | 成都蜀星饲料有限公司 | Zinc oxide enteric-coated sustained-release pellet, preparation method thereof and feed composition containing zinc oxide enteric-coated sustained-release pellet |
| CN114304394A (en) * | 2021-12-14 | 2022-04-12 | 珠海天凯生物科技有限公司 | Coated enteric zinc oxide and preparation process thereof |
| CN114532448A (en) * | 2022-03-11 | 2022-05-27 | 重庆威迪特药业有限责任公司 | Powder-coated zinc oxide preparation with high gastric hyperacidity rate as well as preparation method and application thereof |
| CN115067427A (en) * | 2022-06-02 | 2022-09-20 | 湖北浩华生物技术有限公司 | Enteric coated zinc oxide, preparation method thereof and enteric coated zinc oxide feed |
| EP4183261A1 (en) * | 2021-11-17 | 2023-05-24 | Vepidan ApS | A feed supplement formulation for use in a fodder for feeding a livestock |
| WO2024063664A1 (en) | 2022-09-23 | 2024-03-28 | Beointech D.O.O. Beograd | Ultrasonic low temperature synthesis of an advanced multifunctional additive for application in animal feed production |
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