CN112262926B - Zinc oxide enteric sustained-release pellet, preparation method thereof and feed composition containing zinc oxide enteric-release pellet - Google Patents
Zinc oxide enteric sustained-release pellet, preparation method thereof and feed composition containing zinc oxide enteric-release pellet Download PDFInfo
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- CN112262926B CN112262926B CN202011210355.5A CN202011210355A CN112262926B CN 112262926 B CN112262926 B CN 112262926B CN 202011210355 A CN202011210355 A CN 202011210355A CN 112262926 B CN112262926 B CN 112262926B
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- zinc oxide
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- sustained
- pellet
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- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 title claims abstract description 202
- 239000011787 zinc oxide Substances 0.000 title claims abstract description 101
- 239000008188 pellet Substances 0.000 title claims abstract description 85
- 238000013268 sustained release Methods 0.000 title claims abstract description 47
- 239000012730 sustained-release form Substances 0.000 title claims abstract description 47
- 239000000203 mixture Substances 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title description 10
- 239000010410 layer Substances 0.000 claims abstract description 37
- 229920001542 oligosaccharide Polymers 0.000 claims abstract description 33
- 150000002482 oligosaccharides Chemical class 0.000 claims abstract description 32
- 239000012055 enteric layer Substances 0.000 claims abstract description 22
- 125000005456 glyceride group Chemical group 0.000 claims abstract description 21
- 239000011248 coating agent Substances 0.000 claims abstract description 15
- 238000000576 coating method Methods 0.000 claims abstract description 15
- 239000000341 volatile oil Substances 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 3
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 claims description 16
- 239000006187 pill Substances 0.000 claims description 13
- LKUNXBRZDFMZOK-GFCCVEGCSA-N Capric acid monoglyceride Natural products CCCCCCCCCC(=O)OC[C@H](O)CO LKUNXBRZDFMZOK-GFCCVEGCSA-N 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 7
- 229960001763 zinc sulfate Drugs 0.000 claims description 7
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 7
- ARIWANIATODDMH-UHFFFAOYSA-N Lauric acid monoglyceride Natural products CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 claims description 6
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- 239000002270 dispersing agent Substances 0.000 claims description 6
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- 235000019425 dextrin Nutrition 0.000 claims description 2
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 claims description 2
- 229940107187 fructooligosaccharide Drugs 0.000 claims description 2
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims 1
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- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 8
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
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- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 4
- 150000004667 medium chain fatty acids Chemical class 0.000 description 4
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- 235000019482 Palm oil Nutrition 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
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- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
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- 241000186660 Lactobacillus Species 0.000 description 2
- UYXTWWCETRIEDR-UHFFFAOYSA-N Tributyrin Chemical compound CCCC(=O)OCC(OC(=O)CCC)COC(=O)CCC UYXTWWCETRIEDR-UHFFFAOYSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
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- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000193468 Clostridium perfringens Species 0.000 description 1
- 208000035240 Disease Resistance Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical class OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 241000270322 Lepidosauria Species 0.000 description 1
- 239000000232 Lipid Bilayer Substances 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 244000275012 Sesbania cannabina Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
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- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 244000250129 Trigonella foenum graecum Species 0.000 description 1
- 235000001484 Trigonella foenum graecum Nutrition 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to the technical field of feed additives, and discloses a zinc oxide enteric sustained-release pellet, which comprises a pellet core, a release layer and an enteric layer, wherein the release layer is coated on the surface of the pellet core, and the enteric layer is coated on the surface of the sustained-release pellet; the pellet core comprises zinc oxide and the release layer comprises medium chain fatty acid glycerides and indigestible oligosaccharides. Its preparing process and the feed composition containing it are disclosed. The zinc oxide enteric-coated sustained-release pellet has good zinc oxide coating effect, can effectively avoid zinc oxide from being decomposed in the stomach of piglets, and can enable zinc oxide to be rapidly released in intestinal tracts. The invention can obviously reduce diarrhea of piglets by scientific and reasonable compatibility and by utilizing the synergistic effect of zinc oxide, medium-chain fatty glyceride, oligosaccharide and essential oil, thereby improving the production performance of the piglets.
Description
Technical Field
The invention belongs to the technical field of feed additives, and particularly relates to a zinc oxide enteric sustained-release pellet, a preparation method thereof and a feed composition containing the same.
Background
Diarrhea phenomenon of weaned pigs is very common, and mainly occurs in newborn suckling pigs of 1-3 days old, suckling pigs of 7-20 days old and nursery pigs of 4-15 days after weaning. The diarrhea of piglets causes slow growth and the feed return rate to be reduced, and the survival rate of piglets to be reduced when the diarrhea is serious, so that huge economic loss is brought to the pig industry, and the diarrhea of piglets is particularly important to effectively prevent.
The addition of 3000mg/kg zinc (zinc oxide form) to piglet feed was first reported by danish Poulsen H D in 1989 to reduce diarrhea and significantly promote growth of weaned piglets. Since then, there is a focus on the antidiarrheal mechanism of zinc oxide production, but there is currently no reasonably comprehensive mechanism system that only finds significant dose compliance with the antidiarrheal effect of zinc oxide, only high doses of zinc oxide. However, the detection of feces revealed that 90% -95% of zinc was discharged from the feces, indicating extremely low zinc oxide utilization. The reason for this is: zinc oxide is an amphiphilic molecule which is almost insoluble in water, but has a higher solubility under acidic conditions; when zinc oxide in daily ration reaches the stomach of piglets with pH value of about 3.5-4.5, most insoluble zinc oxide is converted into Zn ions, so that only a small amount of zinc oxide can act in intestinal tracts, and at the same time, a large amount of zinc is discharged out of the body, so that environmental pollution and adverse reactions of animals can be caused. Therefore, how to improve the utilization rate of zinc oxide is a problem to be solved in the current animal husbandry.
At present, zinc oxide is used for being embedded so as to avoid the decomposition of the zinc oxide in the stomach of the piglets, so that the zinc oxide can be effectively delivered into the intestinal tracts of the piglets. For example, the patent with publication number of CN111631315A discloses a feed additive, a preparation method thereof and application thereof in anti-diarrhea of piglets, wherein the decomposition of zinc oxide in stomach is avoided by compounding monoglyceride laurate, tributyrin and zinc oxide, but the colon release rate of the zinc oxide of the product is lower, so that the action effect of the zinc oxide is not substantially improved.
Disclosure of Invention
Aiming at the defect that the existing zinc oxide embedded material has low release rate in the intestinal tract of piglets, the invention aims to provide the zinc oxide enteric-coated sustained-release pellet which has good zinc oxide coating effect, can effectively avoid the decomposition of zinc oxide in the stomach of piglets, and can enable the zinc oxide to be rapidly released in the intestinal tract so as to exert the maximum effect of the zinc oxide.
Specifically, the first object of the invention is to provide a zinc oxide enteric sustained-release pellet, which comprises a pellet core, a release layer and an enteric layer, wherein the release layer is coated on the surface of the pellet core, and the enteric layer is coated on the surface of the sustained-release pellet; the pellet core comprises zinc oxide and the release layer comprises medium chain fatty acid glycerides and indigestible oligosaccharides.
The second aim of the invention is to provide a preparation method of zinc oxide enteric sustained-release pellets, which comprises the following steps:
s1, weighing the components of the zinc oxide enteric sustained-release pellets according to weight;
s2, adding all the components of the pill core into a container, adding medium-chain fatty glyceride, heating and uniformly mixing to obtain a first blend;
s3, adding indigestible oligosaccharides into the first blend in the step S2, uniformly mixing, and carrying out extrusion rolling and sieving treatment to obtain slow-release pellets;
s4, dissolving each component of the enteric layer in water to form suspension dispersion liquid with the mass fraction of 10% -30%;
s5, adding the sustained-release pellets in the step S3 into a coating machine, and performing secondary coating treatment to obtain the zinc oxide enteric sustained-release pellets.
The third object of the invention is to provide a feed composition comprising zinc oxide enteric slow-release pellets.
According to the preparation method, zinc oxide is taken as a pill core, and the release layer and the enteric layer are sequentially coated on the outer surface of the pill core, so that zinc oxide can be efficiently utilized in intestinal tracts, meanwhile, the intestinal health of piglets can be improved, and the growth and development of the piglets are further promoted.
Specifically:
the enteric sustained-release pellet firstly enters the stomach of the piglet through the oral cavity of the piglet, and the enteric sustained-release pellet is coated with the enteric layer which is stable in gastric juice, so that the enteric sustained-release pellet can be prevented from being dissolved in the stomach of the piglet, the enteric layer rapidly disintegrates after entering the intestinal tract through the stomach of the piglet, the sustained-release pellet (namely, the release layer coated with the pellet core) is exposed, and the release layer is at least a composite shell capsule which is formed by taking medium-chain fatty glyceride and indigestible oligosaccharide as compositions.
The medium-chain fatty glyceride is one of the components of the composite shell capsule, has good coating effect, has specific nutrition and metabolism effect, and can rapidly provide energy for young animals and be used as a natural antibacterial product. If zinc oxide is coated by medium-chain fatty glyceride, the medium-chain fatty glyceride is gradually digested and dissolved under the action of intestinal digestive enzymes, the dissolution speed is low, and zinc oxide cannot be rapidly and efficiently released in the intestinal tract, so that the release amount of zinc oxide is low, the effective concentration is difficult to achieve, and especially the maximum effect of zinc oxide in the intestinal tract cannot be achieved when the release of the medium-chain fatty glyceride in the intestinal tract is incomplete due to the large particle size. This is because zinc oxide (in molecular form) needs to be released in the intestinal tract, promoting epithelial cell regeneration by astringing, antibacterial; repairing intestinal damage; increase compact protein expression, strengthen intestinal barrier, reduce intestinal microorganism colonization, and prevent and treat diarrhea of piglets.
The inventor finds that when the enteric layer disintegrates to expose the release layer, the indigestible oligosaccharide is also exposed in intestinal fluid, and under the action of intestinal water environment, the indigestible oligosaccharide absorbs water to expand and is quickly dissolved in the water environment, so that the composite shell is provided with holes, and zinc oxide in the slow-release pellets is quickly released in the intestinal tract, so that the zinc oxide dosage required by the growth and development of piglets can play the maximum effect in the intestinal tract. In addition, the indigestible oligosaccharide is used as a prebiotic factor, the dosage required for exerting the effect is low, the intestinal flora of piglets can be balanced, the intestinal pathogenic bacteria are reduced, the stress of the feed on the piglets after weaning is reduced, the health of the piglets is promoted, the disease resistance is improved, and the diarrhea rate of the piglets is reduced.
The enteric coating is used for coating the release layer, so that the problem of poor feeding performance caused by adding medium-chain fatty glyceride can be solved, and the feed intake of piglets is improved.
The beneficial effects of the invention are as follows:
the enteric-coated sustained-release pellet has good effect of coating zinc oxide, can effectively avoid zinc oxide from being decomposed in the stomach of piglets, ensures that zinc oxide can be rapidly released in intestinal tracts, and plays the maximum effect of zinc oxide.
The enteric sustained-release pellet disclosed by the application takes zinc oxide, medium-chain fatty glyceride and indigestible oligosaccharide as main components, and can improve gastrointestinal microbial flora, promote proliferation of beneficial bacteria, reduce intestinal pathogenic bacteria, regulate animal immune response and promote growth and development of piglets through the synergistic effect of the components.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention will be clearly and completely described below. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.
The invention provides a zinc oxide enteric-coated sustained-release pellet, which comprises a pellet core, a release layer and an enteric-coated layer, wherein the release layer is coated on the surface of the pellet core to form the sustained-release pellet; the pellet core comprises zinc oxide and the release layer comprises medium chain fatty acid glycerides and indigestible oligosaccharides.
In the zinc oxide enteric slow release pellet, the components are 10 to 85 parts of pellet core, 25 to 120 parts of release layer and 1.65 to 5.5 parts of enteric layer according to the weight parts.
Further, the pill core is 10.6 to 85 parts, the release layer is 30 to 120 parts, and the enteric layer is 1.65 to 5.5 parts.
Still further, 13 to 65 parts of pill core, 35 to 105 parts of release layer and 2.2 to 4.3 parts of enteric layer.
In the invention, in the release layer, the mass ratio of the medium-chain fatty glyceride to the indigestible oligosaccharide is 10-60:15-50. Further, the mass ratio of the medium-chain fatty glyceride to the indigestible oligosaccharide is 20-50:15-40.
In the invention, the medium-chain fatty acid glyceride comprises at least one of lauric acid monoglyceride, capric acid monoglyceride or caprylic acid monoglyceride. The medium chain fatty acid monoglyceride has strong antibacterial and antiviral functions. The medium-chain fatty glyceride has the advantages of short carbon chain, quick decomposition, quick absorption, easy energy release and the like, and can be quickly supplied with energy due to easy digestion of the medium-chain fatty glyceride when added into feed, thereby meeting the growth and development requirements of piglets.
In the invention, as the melting point of the capric acid monoglyceride and the caprylic acid monoglyceride is low at normal temperature, the coating effect on zinc oxide is poor, and in order to solve the defect, the coating effect of the capric acid monoglyceride and the caprylic acid monoglyceride can be improved by adopting a mode of adding auxiliary materials. The adjuvants can be long chain fatty acids and/or hydrogenated fats with higher melting point. Long chain fatty acids such as palm oil, hydrogenated fats such as hydrogenated vegetable oils. In addition, when the monoglyceride laurate is added, palm oil, hydrogenated vegetable oil or stearic acid can be added, so that the formed slow-release pellets can play a role in hydrophobic and acid resistance, zinc oxide can be better protected, and zinc oxide is prevented from dissolving out in the stomach environment to the greatest extent.
Monoglyceride Laurate (GML) is a natural antibacterial agent and has good inhibitory effect on gram positive bacteria, partial gram negative bacteria, mold, filamentous fungi, etc. GML is commonly found in plants such as breast milk, coconut oil, and Chinese lizard, has good stability, has an antibacterial effect not affected by the pH value of the environment, and is easy to digest as an energy raw material. GML was found to effect bacterial inhibition by affecting the cell wall, cell membrane, metabolic enzymes and protein synthesis systems of bacterial vegetative cells. The mechanism of the antiviral agent is to kill viruses by affecting lipid bilayer structures in enveloped viruses. Numerous studies have demonstrated that GML can not only improve animal productivity, immune function and meat quality, but also improve liver metabolism and antioxidant capacity in animal production.
The caprylic acid monoglyceride has good antibacterial property on bacteria, and is used as fatty acid ester to be decomposed into glycerin and fatty acid in vivo, and the formed glycerin is metabolized by TCA circulation through the beta-oxidation of fatty acid, and is finally decomposed into carbon dioxide and water to supply energy to a human body. The monoglyceride octanoate is a substance with high safety, and does not cause accumulation and specific reaction due to poor metabolism.
The capric acid monoglyceride is a high-efficiency preservative, has good antibacterial effect, is safe and nontoxic, has digestion, absorption and metabolism speed 40 times that of common long-chain fatty acid, and can not be deposited in organism tissues. The capric acid monoglyceride mainly reduces the permeability and stability of cell membranes through the action of the capric acid monoglyceride on the cell membranes of bacteria, and causes the leakage of intracellular nucleic acid and soluble protein, thereby achieving the antibacterial and bactericidal effects.
In the present invention, the indigestible oligosaccharide includes at least one of an oligoxylan, a galacto-mannooligosaccharide, a mannooligosaccharide, or a fructooligosaccharide. The indigestible oligosaccharide is non-digestible polysaccharide, can not be degraded and absorbed by gastric acid and gastric enzyme of a piglet, has multiple physiological functions, can improve the immunity of the piglet, promote the absorption of mineral elements, has the antioxidant function, improves the intestinal flora structure, and reduces diarrhea of the piglet.
Indigestible oligosaccharides, also called bifidus factors, are not digested and absorbed by the intestinal tract of any animal and promote the proliferation of bifidobacteria, thereby contributing to the intestinal health. The indigestible oligosaccharide has low effective value and sweet taste, can improve the palatability of the feed, and is stable under acidic condition.
The oligosaccharide is a functional polysaccharide, the function of the bifidus factor is 10-20 times that of other polysaccharide, the property is stable, the oligosaccharide is known as a super-strong prebiotic substance, and the oligosaccharide can selectively promote the proliferation activity of intestinal bifidobacteria in animal feed application. The oligosaccharide can effectively promote the increase of the quantity of bifidobacteria and lactobacillus in intestinal tracts and effectively reduce the quantity of clostridium perfringens.
Galactomannooligosaccharides, also known as galactomannooligosaccharides, are mainly derived from sesbania gum, fenugreek gum, carob gum, guar gum and tara gum. The galactomannan-oligosaccharide can promote the growth of beneficial bacteria such as bifidobacteria and lactobacillus in intestinal tracts, inhibit the adhesion and colonization of intestinal walls by harmful bacteria, and maintain normal digestive tract environment. Galactomannooligosaccharides can significantly increase the net uptake of essential amino acids by piglets.
The mannooligosaccharides are also called glucomannooligosaccharides and mannooligosaccharides, are not digested by intestinal digestive enzymes, are stable under acidic and alkaline conditions, can be combined with intestinal mucosa, stimulate intestinal immunity, are combined with bacteria containing corresponding ligands, prevent pathogenic bacteria from colonizing the intestinal tract, can be selectively utilized with beneficial bacteria, and are used for growth and reproduction of the beneficial bacteria.
In the invention, the surface of the release layer is coated with zinc sulfate, and the zinc sulfate is supplied to intestinal tracts of piglets to be digested and absorbed by zinc ions on one hand, and is used as an anti-sticking agent on the other hand, so that adhesion between slow-release pellets is avoided. In the release layer, the mass ratio of the medium-chain fatty glyceride to the indigestible oligosaccharide to the zinc sulfate is 10-60:15-50:5-10.
In the invention, the enteric layer comprises enteric materials and auxiliary materials, and the mass ratio of the enteric materials to the auxiliary materials in the enteric layer is 1.5-5.5:0.15-0.5. Further, the mass ratio of the enteric material to the auxiliary material is 2.0-4.5:0.2-0.3.
The enteric material includes cellulose acetate phthalate, and other conventionally used enteric materials such as at least one of cellulose acetate phthalate, hydroxylmethyl cellulose titanate, acrylic resin L-type, acrylic resin S-type, polyvinyl acetate phthalate, hydroxypropyl methylcellulose acetate succinate, cellulose acetate trimellitate, etc. may be used by those skilled in the art.
The auxiliary material comprises diethyl phthalate which is taken as a plasticizer.
In the invention, the pill core further comprises composite essential oil, wherein the composite essential oil comprises plant essential oil and a dispersing agent, and the dispersing agent is starch and/or dextrin; in the pill core, the mass ratio of the zinc oxide to the plant essential oil to the dispersing agent is 10-70:0.1-5:0.5-10.
In the present invention, the plant essential oil includes at least one of oregano oil, thymol, or cinnamaldehyde.
The pasty compound essential oil formed by diluting the essential oil with starch is mixed with zinc oxide to form particles, and then the particles are embedded by utilizing a compound capsule shell, and the medium-chain fatty acid monoglyceride is oily substance, and then the pellet core is coated, so that a stable oil-in-oil stable structure can be formed, on one hand, the release of zinc oxide in the stomach of piglets can be avoided, and on the other hand, the essential oil also has an antibacterial effect, and the zinc oxide and the medium-chain fatty acid ester are combined to promote the growth and development of the piglets.
The invention provides a preparation method of zinc oxide enteric sustained-release pellets, which comprises the following steps:
s1, weighing the components of the zinc oxide enteric sustained-release pellets according to weight;
s2, adding all the components of the pill core into a container, adding medium-chain fatty glyceride, heating and uniformly mixing to obtain a first blend;
s3, adding indigestible oligosaccharides into the first blend in the step S2, uniformly mixing, and carrying out extrusion rolling and sieving treatment to obtain slow-release pellets;
s4, dissolving each component of the enteric layer in water to form suspension dispersion liquid with the mass fraction of 10% -30%;
s5, adding the sustained-release pellets in the step S3 into a coating machine, and performing secondary coating treatment to obtain the zinc oxide enteric sustained-release pellets.
In the invention, medium-chain fatty glyceride is preheated and melted.
S3, controlling the sieving grain diameter to be 0.25-0.55 mm.
The zinc oxide enteric sustained-release pellet disclosed by the application is simple in preparation method, and the surface of zinc oxide is coated with a release layer and a secondary enteric layer. The enteric layer is used for providing a safe environment of the sustained-release pellets in the stomach of the piglet and avoiding dissolution in the stomach of the piglet, so that the zinc oxide enteric sustained-release pellets enter the intestinal tract from the stomach environment, and the enteric layer begins to dissolve in the intestinal tract to expose the sustained-release pellets. The indigestible oligosaccharide in the slow release pellet is rapidly dissolved in water and used as a pore-forming agent of the slow release pellet, so that zinc oxide is rapidly released.
Thirdly, the invention provides a feed composition, which comprises zinc oxide enteric sustained-release pellets, wherein the zinc oxide enteric-release pellets account for 0.05-0.15% of the feed composition by weight.
< example >
Examples 1 to 8
The compositions of the zinc oxide enteric slow release pellets of examples 1 to 8 are shown in Table 1.
Table 1 component proportions of examples
Example 9
A method for preparing the zinc oxide enteric sustained-release pellets in preparation examples 1 to 8, comprising the following steps:
weighing the components of the pill core, the release layer and the enteric layer according to weight; uniformly mixing the components of the pill core, adding medium-chain fatty acid monoglyceride in a molten state, carrying out heat preservation and mixing for 10min, then adding indigestible oligosaccharide, continuously mixing, extruding while hot, rounding, sieving, and obtaining the sustained-release pellets with the sieving diameter of 0.25-0.55 mm; if the medium-chain fatty acid monoglyceride selects the capric acid monoglyceride or the caprylic acid monoglyceride, only a small amount of palm oil or hydrogenated vegetable oil is needed to be added, so that the capric acid monoglyceride or the caprylic acid monoglyceride can be solidified at normal temperature after the pellet core is coated to form a slow-release pellet;
preparing an enteric material into a water suspension with the mass fraction of 20%, and adding auxiliary materials while stirring to obtain a blending solution;
and (3) placing the slow-release pellets in a coating machine, spraying liquid for coating night, and spraying the blending liquid to obtain the zinc oxide enteric slow-release pellets, wherein the particle size of the pellets is controlled to be 0.25-0.55 mm.
When zinc sulfate is added, the zinc sulfate can be adhered to the surface of the sustained-release pellets by adding the components during the rounding treatment.
Example 10
The difference between this example and example 1 is that the lauric acid monoglyceride is replaced with lauric acid monoglyceride and capric acid monoglyceride in the release layer, the mass ratio of lauric acid monoglyceride to capric acid monoglyceride is 2:1, and the total amount of the release layer added is not changed, but the release layer may be a composition of at least two of lauric acid monoglyceride, capric acid monoglyceride and caprylic acid monoglyceride, and the mass ratio thereof may be appropriately adjusted according to the actual needs.
Example 11
The difference between this example and example 1 is that the composition of at least two of the oligosaccharides, galacto-mannooligosaccharides, or fructooligosaccharides is replaced with the oligosaccharide in the release layer, and the mass ratio thereof can be appropriately adjusted according to the actual requirements.
Example 12
This example differs from example 9 in that the enteric material is made as a 10% mass fraction aqueous suspension.
Example 13
This example differs from example 9 in that the enteric material is made as a 30% by mass aqueous suspension.
Example 14
A feed composition comprising the enteric zinc oxide sustained-release pellets obtained in any of examples 1 to 13, wherein the zinc oxide is added in an amount of 0.1%, but may be 0.05%, 0.08%, 0.12% or 0.15%.
Comparative example
Comparative example 1
The proportions of the components of the zinc oxide coated pellets of comparative example 1 are shown in Table 2.
Table 2 comparative examples the proportions of the components
The preparation method is the same as that of example 9.
<Test example 1 acid-resistant gastric-pass rate test and intestinal disintegration rate simulation test>
The samples were tested according to the 0931 dissolution and release rate assay in the examination of the 0900 Properties of the fourth part of the pharmacopoeia of the people's republic of China, 2015 edition.
The zinc oxide enteric sustained release pellets in examples 1 to 8 were used as test samples, and acid-resistant gastric-pass rate test and intestinal disintegration rate test were carried out, and the results are shown in table 3.
TABLE 3 results of enteric-coated sustained-release pellets of zinc oxide in simulating the release rate in intestines and stomach
As shown in the experimental results of table 3, the release amount of the zinc oxide enteric sustained-release pellets in the artificial gastric juice is small, and the release amount in the artificial intestinal juice and the artificial colon juice is high, which indicates that the zinc oxide enteric-release pellets are obtained after the enteric-coated layer prepared by the enteric-coated material and the zinc oxide coated by the medium-chain fatty glyceride and the indigestible oligosaccharide are used as the release layers, so that the release of zinc oxide in the stomach can be effectively slowed down, and a large amount of zinc oxide can be released in the intestinal juice. Whereas the release rate of the active zinc oxide in comparative example 1, in which only the medium chain fatty acid glyceride was coated in the release layer, was low in the intestinal tract, affecting the effect of zinc oxide.
<Test example 2 weaned piglet application test>
The genetic characteristics are consistent, the health state is good, 220 weaned piglets with the weight close to 25 days old are divided into 11 groups, each group is divided into 2 repeats, and 10 piglets (five piglets in male and female).
The zinc oxide enteric sustained-release pellets in examples 1 to 8 are adopted as experimental groups 1 to 8, and the addition amount of the experimental groups 1 to 8 is 1kg per ton of feed; adopting comparative example 1 as a control group 1, wherein the weight ratio of the additive amount of the control group 1 in the feed is the same as that of the experimental group in the feed; two well-known brands of coated zinc oxide A, B (one each in China/import) on the market were purchased as control groups 2 to 3, and the addition amounts of the control groups 2 to 3 were added according to the specifications.
The test period is 30 days after weaning, the test records, the feed intake, daily gain and feed conversion ratio index are shown in Table 4.
Table 4 weaned piglet feed test results
As shown in Table 3, the average daily gain of piglets can be improved and the feed conversion ratio can be reduced in all experimental groups; compared with the control groups 1 to 3, the diarrhea rate of the experimental group is obviously reduced, and the highest reduction reaches 59.11 percent.
The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, but various modifications and variations can be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (6)
1. The zinc oxide enteric-coated sustained-release pellet is characterized by comprising a pellet core, a release layer and an enteric-coated layer, wherein the release layer is coated on the surface of the pellet core to form the sustained-release pellet;
the pellet core comprises zinc oxide, and the release layer comprises medium chain fatty glyceride and indigestible oligosaccharide;
the composition comprises, by weight, 10-85 parts of pill cores, 25-120 parts of release layers and 1.65-5.5 parts of enteric layers;
in the release layer, the mass ratio of the medium-chain fatty glyceride to the indigestible oligosaccharide is 10-60:15-50;
the medium-chain fatty acid glyceride comprises at least one of lauric acid monoglyceride, capric acid monoglyceride or caprylic acid monoglyceride;
the indigestible oligosaccharide comprises at least one of xylooligosaccharide, galacto-mannooligosaccharide, or fructooligosaccharide.
2. The zinc oxide enteric sustained-release pellet of claim 1, wherein the surface of the release layer is coated with zinc sulfate, and the mass ratio of medium-chain fatty glyceride, indigestible oligosaccharide and zinc sulfate is 10-60:15-50:5-10.
3. The zinc oxide enteric sustained-release pellet according to claim 1, wherein the enteric layer comprises cellulose acetate phthalate and diethyl phthalate, and the mass ratio of the cellulose acetate phthalate to the diethyl phthalate is 1.5-5.5:0.15-0.5.
4. The zinc oxide enteric sustained-release pellet according to claim 1, wherein the pellet core further comprises a compound essential oil, the compound essential oil comprises a plant essential oil and a dispersing agent, and the dispersing agent is starch and/or dextrin;
in the pill core, the mass ratio of the zinc oxide to the plant essential oil to the dispersing agent is 10-70:0.1-5:0.5-10.
5. A method for preparing the zinc oxide enteric sustained-release pellets according to any one of claims 1 to 4, comprising the steps of:
s1, weighing the components of the zinc oxide enteric sustained-release pellets according to weight;
s2, adding all the components of the pill core into a container, adding medium-chain fatty glyceride, heating and uniformly mixing to obtain a first blend;
s3, adding indigestible oligosaccharides into the first blend in the step S2, uniformly mixing, and carrying out extrusion rolling and sieving treatment to obtain slow-release pellets;
s4, dissolving each component of the enteric layer in water to form suspension dispersion liquid with the mass fraction of 10% -30%;
s5, adding the sustained-release pellets in the step S3 into a coating machine, and performing secondary coating treatment to obtain the zinc oxide enteric sustained-release pellets.
6. A feed composition comprising the zinc oxide enteric slow release pellet of any one of claims 1 to 4.
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| CN111631315A (en) * | 2020-06-19 | 2020-09-08 | 无锡金源博新材料有限公司 | Feed additive, preparation method thereof and application thereof in resisting piglet diarrhea |
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| CN102308916A (en) * | 2011-08-04 | 2012-01-11 | 珠海天凯生物科技有限公司 | Novel enteric sustained-release pellet for feed and preparation method thereof |
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