CN112641002B - Feed composition added with tiepin coating compound acidifier - Google Patents
Feed composition added with tiepin coating compound acidifier Download PDFInfo
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- CN112641002B CN112641002B CN202011475356.2A CN202011475356A CN112641002B CN 112641002 B CN112641002 B CN 112641002B CN 202011475356 A CN202011475356 A CN 202011475356A CN 112641002 B CN112641002 B CN 112641002B
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
- A23K10/22—Animal feeding-stuffs from material of animal origin from fish
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/26—Compounds containing phosphorus
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Abstract
A feed composition with a coating acidulant for the addition of a drug-loaded pellet core and an acrylic resin coating is disclosed, comprising a base feed and a coating acidulant, wherein the acidulant is a combination of fumaric acid and potassium diformate. With the feed composition according to the invention, the weaned pigs not only grow faster but also have a significantly reduced diarrhea rate.
Description
Technical Field
The invention belongs to the technical field of animal feed, and relates to a feed composition added with a tie-coat compound acidulant.
Background
In recent years, the pig raising industry in China is in a situation of insufficient supply as a whole due to the influence of environmental protection, epidemic situation and cost of upstream raw feed. In order to maximize the reproductive performance of adult sows, a method for early weaning of piglets (3-4 weeks old) is generally adopted. However, since the digestive system of piglets is not yet developed, the nervous and endocrine regulation system is not yet fully established at this time.
Within 3-4 weeks after weaning, the lactic acid yield in the digestive tract of piglets is greatly reduced, and the endogenous gastric acid secretion is insufficient to compensate for the reduction of lactic acid; furthermore, part of gastric acid is easy to combine with feed raw materials. The pH value of the alimentary canal of the weaned piglets is higher than the level after weaning, and in addition, pathogenic microorganisms, inadaptation of feeding environment and other factors, the stress response of the piglets can be caused in the transition stage from the feeding of breast milk to the feeding of solid feed, including poor appetite, slow growth speed, diarrhea rate and death rate increase after weaning. These stress responses are collectively referred to as "early weaning stress syndrome".
In order to prevent and treat the above stress response of piglets, antibiotics are generally added to pig feed to control inflammatory response caused by various infections other than viral diseases. However, the use of antibiotics is twofold, brings great benefits, and also circulates into the human body through food intake, environmental residues and other modes, thereby endangering the health and environmental safety of the human body. Under such a large background, the world has been increasingly subjected to quite strict laws and regulations for the use of antibiotics in livestock and poultry farming. Taking the European Union as an example, the addition of antibiotic growth-promoting feed additives to animal-derived foods was completely prohibited in 2006. The national veterinary drug (antibacterial drug) comprehensive treatment five-year action scheme (2015-2019) of the export of China comprehensively prohibits the addition of antibiotics in the feed. Thus, there is an increasing demand for efficient and food-safe antibiotic alternatives (abbreviated as "tie") by livestock producers.
As antibiotic substitutes, more plant extracts (e.g., chinese herbal medicines and essential oils), microbial agents (e.g., enzyme preparations and probiotics), acidulants (e.g., inorganic and organic acids and salts thereof), and metal ion-based antibacterial agents (e.g., high zinc and high copper products), etc. are used.
Chinese patent CN107319131B discloses a preparation method and application of a natural anti-functional feed additive, wherein the natural anti-functional feed additive is prepared from natural anti-functional materialsThe additive is an amorphous powder solid preparation containing anti-drug-resistant bacteria and anti-inflammatory components, and the amorphous powder solid preparation comprises the following components in percentage by weight: 1, peony seed meal powder and soybean meal powder; wherein the peony seed meal contains 2.5-3.0% of anti-drug-resistant bacteria and anti-inflammatory components. The invention discloses a natural anti-G feed additive, which comprises the following raw materials in percentage by weight + Bacteria positive bacteria and simultaneously has bactericidal effect. The feed additive provided by the invention is used for livestock and even ruminants, can improve the growth performance, and has an antibiotic-like effect. However, the invention needs to squeeze oil from peony seed fruits and soybeans by screw squeezing, pulverize and screen the rest cake, mix, oven dry and sterilize to obtain amorphous powder solid preparation, the whole process is complex, and the process applicability is complex.
The Chinese patent application CN109511811A discloses a medium-short chain fatty acid essential oil preparation for a tiepiece and a preparation method and application thereof, wherein the medium-short chain fatty acid essential oil preparation for a tiepiece is mainly prepared from the following raw materials, by weight, 5-20 parts of formic acid, 5-20 parts of butyric acid, 1-5 parts of caproic acid, 1-5 parts of caprylic acid, 1-5 parts of capric acid, 5-20 parts of lauric acid, 3-10 parts of ammonia gas, 5-15 parts of glycerin, 1-5 parts of oregano oil and 20-40 parts of silicon dioxide, and the medium-short chain fatty acid essential oil preparation for a tiepiece can replace antibiotics to play a good role of sterilization and bacteriostasis, promote animal growth and avoid environmental pollution. However, the short-chain fatty acid essential oil preparation in the tiepin contains up to 6 acid types, and contains gas raw materials such as ammonia gas and solid raw materials of silicon dioxide, so that the formula stability is unsatisfactory.
In summary, acidulants are preferred antibiotic substitutes from the standpoint of the formulation stability and process suitability of the feed additives.
The acidulant includes organic acidulant and inorganic acidulant. The former is mainly citric acid, fumaric acid, lactic acid, formic acid, propionic acid, etc.; the organic acid has good flavor and can directly enter the tricarboxylic acid cycle in the body. The latter mainly comprises sulfuric acid, hydrochloric acid, phosphoric acid and the like; the inorganic acid has better pH value reduction and sterilization effects.
However, whatever acidulant is, it is corrosive and affects mineral metabolism in animals. In addition, the acidulant has the defect of unstable use effect, and mainly comprises the following components: the acidifier has high absorption speed in the stomach, and can inhibit gastric acid secretion and normal development of gastric functions; the acidulant only has a small part reaching the small intestine and the large intestine, can not effectively reduce the pH value in the small intestine, and is difficult to inhibit the growth of escherichia coli. This results in poor appetite and slow growth rate in weaned pigs; meanwhile, the diarrhea rate is higher.
On the other hand, there are few complex acidulants in the prior art. The acidulant can realize broad-spectrum bacteriostasis and bacteriostasis function in a wider pH value range. Different kinds of acidulants have different effects on the palatability of the feed.
The inventor has found through scientific investigation that as a compound acidulant, a document report of a combination of both fumaric acid and potassium diformate has not yet been found. However, the addition of organic acid to the ration of weaned pigs is known to improve the productivity of the pigs; potassium diformate is the first non-antibiotic feed additive approved by the european union for replacement of antibiotics. Both have the functions of resisting bacterial infection, improving the nutrient digestibility of feed and the like, and have obvious growth promoting effect on piglets and growing-finishing pigs.
The inventor finds that the effect of the composite acidulant obtained by combining the two is better than that of a single acidulant in improving the production performance of animals.
In combination with the above two reasons, there is still a need to find a feed composition with a coating compound acidulant for tie-coat which has a faster growth rate and a lower diarrhea rate.
Disclosure of Invention
The invention aims to provide a feed composition added with a tie-coat compound acidifier. By using the feed composition provided by the invention, the weaned pigs grow faster and the diarrhea rate is obviously reduced.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a feed composition comprising a basal feed and a coated composite acidulant, the acidulant being a combination of fumaric acid and potassium diformate, characterized in that the coated composite acidulant comprises a pellet-carrying core and an acrylic resin coating layer.
The feed composition according to the invention, wherein the basal feed is: 60-68% of corn; 18-26% of bean pulp; 2-6% of premix; whey powder 1-5%; wheat bran 1-5%; 0.5-4% of fish meal; soybean oil 0.5-1.5%; 0.2 to 1.2 percent of calcium hydrophosphate; sodium chloride 0.1-0.3%.
Preferably, the basic feed is: 62-66% of corn; 20-24% of soybean meal; 3-5% of premix; whey powder 2-4%; wheat bran 2-4%; 1-3% of fish meal; soybean oil 0.8-1.2%; 0.5 to 1.0 percent of calcium hydrophosphate; sodium chloride 0.15-0.25%.
In a specific embodiment, the basal feed is: 64% of corn; bean pulp 22%; 4% of premix; 3% of whey powder; 3% of wheat bran; 2% of fish meal; 1% of soybean oil; 0.8% of calcium hydrophosphate; sodium chloride 0.2%.
The feed composition according to the invention, wherein per kilogram of premix, there is provided: vitamin A5800-6400IU; vitamin D 3 1800-2400IU; vitamin E6-14 IU; vitamin K 3 0.5-4mg, vitamin B 1 1-5mg; vitamin B 2 1-5mg; vitamin B 12 6-14 mug; biotin 0.2-0.8mg; folic acid 0.5-1.5mg; nicotinamide 5-25mg; 5-15mg of calcium pantothenate; 50-90mg of Fe; zn 40-80mg; 15-35mg of Cu; mn 30-50mg; se 0.1-0.5mg; i0.4-0.8 mg; and the premix does not contain antibiotics.
Preferably, per kilogram of premix, there is provided: vitamin A6000-6200 IU; vitamin D 3 2000-2200IU; vitamin E8-12 IU; vitamin K 3 1-3mg, vitamin B 1 2-4mg; vitamin B 2 2-4mg; vitamin B 12 8-12 mug; biotin 0.3-0.7mg; folic acid 0.8-1.2mg; 10-20mg of nicotinamide; 8-12mg of calcium pantothenate; fe 60-80mg; zn 50-70mg; cu 20-30mg; mn 35-45mg; se 0.2-0.4mg; i0.5-0.7 mg; and the premix does not contain antibiotics.
In a specific embodiment, per kilogram of premix, there is provided: vitamin A6100 IU; vitamin D 3 2100IU; vitaminsE10IU; vitamin K 3 2mg, vitamin B 1 3mg; vitamin B 2 3mg; vitamin B 12 10 μg; biotin 0.5mg; folic acid 1mg; 15mg of nicotinamide; 10mg of calcium pantothenate; fe 70mg; zn 60mg; cu 25mg; mn 40mg; se 0.3mg; i0.6 mg; and the premix does not contain antibiotics.
The feed composition according to the present invention, wherein the coating compound acidulant is added in an amount of 0.8-2.5wt%.
Preferably, the coating compound acidulant is added in an amount of 1.2-1.8wt%.
In a specific embodiment, the coating complex acidulant is added in an amount of 1.5wt%.
The feed composition according to the present invention, wherein the pellet-carrying core is prepared by mixing solid raw materials and a binder to prepare a soft material and then performing an extrusion-spheronization operation.
The feed composition according to the invention, wherein the solid raw material of the pellet-carrying core is selected from the group consisting of a mixture of complex acidulant, corn starch, sodium carboxymethyl starch, white carbon black and microcrystalline cellulose.
The feed composition of the invention, wherein the weight ratio of the compound acidulant, corn starch, sodium carboxymethyl starch, white carbon black and microcrystalline cellulose is (25-35): (25-35): (2-6): (6-10): (24-32).
Preferably, the weight ratio of the composite acidulant, corn starch, sodium carboxymethyl starch, white carbon black and microcrystalline cellulose is (20-30): (20-30): (3-5): (7-9): (26-30).
In a specific embodiment, the weight ratio of the compound acidulant, corn starch, sodium carboxymethyl starch, white carbon black and microcrystalline cellulose is 25:25:4:8:28.
the feed composition according to the invention, wherein the binder is selected from 0.5-4wt% hydroxypropyl methylcellulose (HPMC E3) aqueous solution; the addition amount is 20-50v% of the solid material volume.
Preferably, the binder is selected from 1-3wt% hpmc E3 in water; the addition amount is 30-40v% of the solid material volume.
In a specific embodiment, the binder is selected from the group consisting of 2wt% aqueous hpmc E3; the addition amount is one third of the volume of the solid material.
The feed composition according to the invention, wherein the technological parameters of the rounding operation are: the rolling speed is 300-700rpm, and the rolling time is 1-5min.
Preferably, the rounding speed is 400-600rpm and the rounding time is 2-4min.
In a specific embodiment, the spheronization speed is 500rpm and the spheronization time is 3 minutes.
The feed composition according to the present invention, wherein the acrylic resin coating layer is prepared by subjecting drug-loaded pellets to a bottom spray coating using a coating liquid.
The feed composition of the invention, wherein the coating liquid is: 6-12 parts by weight of acrylic resin; 80-120 parts by weight of 90v% ethanol aqueous solution; 1-3 parts of talcum powder; 0.5 to 1.5 weight portions of triethyl citrate.
Preferably, the coating liquid is: 8-10 parts of acrylic resin; 90-110 parts by weight of a 90v% ethanol aqueous solution; 1.5-2.5 parts of talcum powder; 0.8-1.2 parts by weight of triethyl citrate.
In a specific embodiment, the coating solution is: 9 parts by weight of an acrylic resin; 100 parts by weight of a 90v% ethanol aqueous solution; 2 parts of talcum powder; 1 part by weight of triethyl citrate.
The feed composition according to the invention, wherein the acrylic resin is selected from the group consisting of Eudragit L100 and Eudragit S100; the weight ratio of the two is (4-8): (2-4).
Preferably, the acrylic resin is selected from the group consisting of Eudragit L100 and Eudragit S100 in combination; the weight ratio of the two is (5-7): (2.5-3.5).
In a specific embodiment, the acrylic resin is selected from the group consisting of Eudragit L100 and Eudragit S100; the weight ratio of the two is 2:1.
the feed composition according to the present invention, wherein the acrylic resin coating layer has a weight gain of 18-26wt%.
Preferably, the acrylic coating layer has a weight gain of 20-24wt%.
In a specific embodiment, the acrylic coating layer has a weight gain of 22wt%.
The feed composition according to the invention, wherein the process parameters of the primer coating are: the air inlet temperature is 40-60 ℃, the material temperature is 35-55 ℃, the working frequency is 40-60Hz, the spraying pressure is 0.08-0.18MPa, and the spraying speed is 0.5-1.5mL/min.
Preferably, the air inlet temperature is 45-55 ℃, the material temperature is 40-50 ℃, the working frequency is 45-55Hz, the spraying pressure is 0.1-0.15MPa, and the spraying speed is 0.8-1.2mL/min.
In a specific embodiment, the air inlet temperature is 50 ℃, the material temperature is 45 ℃, the working frequency is 50Hz, the spraying pressure is 0.12MPa, and the spraying speed is 1mL/min.
The beneficial technical effects of the invention are as follows: by using the feed composition provided by the invention, the weaned pigs grow faster and the diarrhea rate is obviously reduced.
Without wishing to be bound by any theory, the drug-loaded cores and coating layers of a particular formulation of the anti-coating acidulant in the feed composition act synergistically to achieve the above-described effects.
Detailed Description
The examples are presented for better illustration of the present invention, but are not intended to limit the scope of the present invention to the examples.
Coating acidulant
The weight ratio of the fumaric acid to the potassium diformate is 3:2, mixing to form the compound acidulant. According to 25:25:4:8:28, sieving a compound acidulant, corn starch, sodium carboxymethyl starch, white carbon black and microcrystalline cellulose through a 100-mesh sieve, uniformly mixing, and then adding a 2wt% hydroxypropyl methylcellulose (HPMC E3) aqueous solution with the volume of one third of the solid material to prepare a soft material. Placing the uniformly mixed soft material into an extrusion-spheronization machine, and extruding the soft material into a strip-shaped soft material through a screen with the aperture of 0.8mm at the rotating speed of 50 rpm; then rounding the strip-shaped soft material; the rolling rotation speed is 500rpm, and the rolling time is 3min; obtaining the drug-loaded pellets with high sphericity. And drying the drug-loaded pellets at 50 ℃ for 2 hours, and sieving and retaining the drug-loaded pellets with 20-30 meshes.
Taking 6 parts by weight and 3 parts by weight of Eudragit L100 and Eudragit S100 respectively, adding the 6 parts by weight and the 3 parts by weight into 100 parts by weight of 90v% ethanol water solution, and stirring the mixture to completely dissolve the mixture; and adding 2 parts by weight and 1 part by weight of talcum powder and triethyl citrate respectively, and uniformly mixing to obtain the coating liquid. And (3) placing the drug-loaded pellets into a fluidized bed granulating and coating machine for bottom spray coating, and controlling the weight gain of the coating to be 22wt%. The air inlet temperature is 50 ℃, the material temperature is 45 ℃, the working frequency is 50Hz, the spraying pressure is 0.12MPa, and the spraying speed is 1mL/min. And continuously stirring the coating liquid in the coating process, and drying the coating liquid at 50 ℃ for 10min after coating to obtain the tianti-coating compound acidifier.
Example 1
The feed formula is basic feed plus 1.5wt% of the tie-resistant compound acidifier. Wherein, the basic feed is: 64% of corn; bean pulp 22%; 4% of premix; 3% of whey powder; 3% of wheat bran; 2% of fish meal; 1% of soybean oil; 0.8% of calcium hydrophosphate; sodium chloride 0.2%. Each kilogram of premix provides: vitamin A6100 IU; vitamin D 3 2100IU; vitamin E10IU; vitamin K 3 2mg, vitamin B 1 3mg; vitamin B 2 3mg; vitamin B 12 10 μg; biotin 0.5mg; folic acid 1mg; 15mg of nicotinamide; 10mg of calcium pantothenate; fe 70mg; zn 60mg; cu 25mg; mn 40mg; se 0.3mg; i0.6 mg; and the premix does not contain antibiotics.
Comparative example 1
The feed formula is basic feed plus 1wt% of fumaric acid and potassium diformate (weight ratio is 3:2). Wherein, the basic feed is: 64% of corn; bean pulp 22%; 4% of premix; 3% of whey powder; 3% of wheat bran; 2% of fish meal; 1% of soybean oil; 0.8% of calcium hydrophosphate; sodium chloride 0.2%. Each kilogram of premix provides: vitamin A6100 IU; vitamin D 3 2100IU; vitamin E10IU; vitamin K 3 2mg, vitamin B 1 3mg; vitamin B 2 3mg; vitamin B 12 10 μg; biotin 0.5mg; folic acid 1mg; 15mg of nicotinamide; 10mg of calcium pantothenate; fe 70mg; zn 60mg; cu 25mg; mn 40mg; se 0.3mg; i0.6mg; and the premix does not contain antibiotics.
Feeding test
Selecting 72 ternary hybridization fattening pigs which are healthy and have the same weight and are 28 days old; the animals were thoroughly and randomly divided into 3 groups (test III: feed of example 1; test IV: feed of comparative example 1; control group: 100wt% basal feed) according to the test requirements, 4 replicates (columns) each, 6 replicates each, and the male-female ratio was identical, and the feeding test was performed.
In the pig raising process, the pig house is regularly disinfected and immunized according to the conventional raising management (the temperature is controlled at 24-28 ℃ and the humidity is controlled at 55-70%). A water fountain and a trough are arranged in the pig house, and the pig house is fed for 3 times per day; the following morning the residue was collected and weighed. The test period was 28 days.
The feed intake and daily gain of each pig of each group were accurately recorded daily during the test period, and the Average Daily Gain (ADG) and diarrhea rate during the test period were calculated. Wherein, diarrhea rate= [ number of diarrhea heads/(number of piglet heads test days) ] × 100%.
The results are shown in Table 1.
TABLE 1
| Numbering device | ADG/g | Diarrhea rate/% |
| Test group III | 351.5±12.7 | 5.1 |
| Test group IV | 342.7±10.4 | 6.8 |
| Control group | 308.2±11.5 | 11.6 |
As a result, it can be seen that the weaned pigs according to example 1 of the present invention not only grew faster but also had significantly reduced diarrhea rate compared to comparative example 1 and the control group.
It should be understood that the description of the specific embodiments is merely illustrative of the principles and spirit of the invention, and not in limitation thereof. Further, it should be understood that various changes, substitutions, omissions, modifications, or adaptations to the present invention may be made by those skilled in the art after having read the present disclosure, and such equivalent embodiments are within the scope of the present invention as defined in the appended claims.
Claims (1)
1. The feed composition comprises a basic feed and a coating compound acidifier, wherein the acidifier is a combination of fumaric acid and potassium diformate, and is characterized in that the coating compound acidifier consists of a pill-carrying core and an acrylic resin coating layer;
wherein, the basic feed is: 60-68% of corn; 18-26% of bean pulp; 2-6% of premix; whey powder 1-5%; wheat bran 1-5%; 0.5-4% of fish meal; soybean oil 0.5-1.5%; 0.2 to 1.2 percent of calcium hydrophosphate; sodium chloride 0.1-0.3%; each kilogram of premix provides: vitamin A5800-6400IU; vitamin D 3 1800-2400IU; vitamin E6-14 IU; vitamin K 3 0.5-4mg, vitamin B 1 1-5mg; vitamin B 2 1-5mg; vitamin B 12 6-14 mug; biotin 0.2-0.8mg; folic acid 0.5-1.5mg; nicotinamide 5-25mg; 5-15mg of calcium pantothenate; 50-90mg of Fe; zn 40-80mg; 15-35mg of Cu; mn 30-50mg; se 0.1-0.5mg; i0.4-0.8 mg; the premix does not contain antibiotics;
the addition amount of the coating compound acidifier is 0.8-2.5wt%;
the pill carrying core is prepared by mixing solid raw materials and an adhesive to prepare a soft material and then performing extrusion-spheronization operation; the technological parameters of the rounding operation are as follows: the rolling rotation speed is 300-700rpm, and the rolling time is 1-5min;
the solid raw materials of the pill carrying core are selected from a mixture of a compound acidulant, corn starch, sodium carboxymethyl starch, white carbon black and microcrystalline cellulose; the weight ratio of the composite acidulant, corn starch, sodium carboxymethyl starch, white carbon black and microcrystalline cellulose is (25-35): (25-35): (2-6): (6-10): (24-32);
the binder is selected from 0.5-4wt% hydroxypropyl methylcellulose HPMC E3 aqueous solution; the addition amount is 20-50% of the volume of the solid material;
the acrylic resin coating layer is prepared by using coating liquid to carry out bottom spray coating on the drug-loaded pellets; the technological parameters of the bottom spray coating are as follows: the air inlet temperature is 40-60 ℃, the material temperature is 35-55 ℃, the working frequency is 40-60Hz, the spraying pressure is 0.08-0.18MPa, and the spraying speed is 0.5-1.5mL/min;
the coating liquid comprises the following components: 6-12 parts by weight of acrylic resin; 80-120 parts by weight of 90v% ethanol aqueous solution; 1-3 parts of talcum powder; 0.5-1.5 parts by weight of triethyl citrate;
the acrylic resin is selected from the group consisting of Eudragit L100 and Eudragit S100; the weight ratio of the two is (4-8): (2-4);
the weight gain of the acrylic resin coating layer is 18-26wt%.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011475356.2A CN112641002B (en) | 2020-12-14 | 2020-12-14 | Feed composition added with tiepin coating compound acidifier |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009006475A1 (en) * | 2007-07-03 | 2009-01-08 | Novus International Inc. | Piglet feed rations having low levels of fermentable carbohydrates |
| CN102228154A (en) * | 2011-06-30 | 2011-11-02 | 北京九州大地生物技术集团股份有限公司 | Efficient and green diarrhea-preventing feed additive composite for weaned pigs |
| CN102524533A (en) * | 2010-12-29 | 2012-07-04 | 安徽丰原格拉特乳酸有限公司 | Coated acidifier and preparation method thereof |
| CN102578387A (en) * | 2012-02-03 | 2012-07-18 | 北京大北农科技集团股份有限公司 | Slowly-released compound acidifier for poultry and livestock feed, preparation method thereof and feed |
| CN104222630A (en) * | 2014-09-09 | 2014-12-24 | 上海邦成生物工程有限公司 | Coated acidifying agent for feed and preparation method thereof |
| CN109566878A (en) * | 2018-12-25 | 2019-04-05 | 乐山市瑞和祥动物保健药业有限公司 | A kind of compound acidulant sustained release pellet and preparation method thereof |
| CN111228234A (en) * | 2020-01-07 | 2020-06-05 | 宋凤香 | Coated lidocaine and preparation method and application thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10231891A1 (en) * | 2002-07-12 | 2004-01-22 | Basf Ag | Coated formulation containing sodium, potassium, cesium and/or ammonium diformate is used in premix for animal feed or additive, as performance and/or growth promoter; acidifier; preservative or silage or in fertilizer |
-
2020
- 2020-12-14 CN CN202011475356.2A patent/CN112641002B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009006475A1 (en) * | 2007-07-03 | 2009-01-08 | Novus International Inc. | Piglet feed rations having low levels of fermentable carbohydrates |
| CN102524533A (en) * | 2010-12-29 | 2012-07-04 | 安徽丰原格拉特乳酸有限公司 | Coated acidifier and preparation method thereof |
| CN102228154A (en) * | 2011-06-30 | 2011-11-02 | 北京九州大地生物技术集团股份有限公司 | Efficient and green diarrhea-preventing feed additive composite for weaned pigs |
| CN102578387A (en) * | 2012-02-03 | 2012-07-18 | 北京大北农科技集团股份有限公司 | Slowly-released compound acidifier for poultry and livestock feed, preparation method thereof and feed |
| CN104222630A (en) * | 2014-09-09 | 2014-12-24 | 上海邦成生物工程有限公司 | Coated acidifying agent for feed and preparation method thereof |
| CN109566878A (en) * | 2018-12-25 | 2019-04-05 | 乐山市瑞和祥动物保健药业有限公司 | A kind of compound acidulant sustained release pellet and preparation method thereof |
| CN111228234A (en) * | 2020-01-07 | 2020-06-05 | 宋凤香 | Coated lidocaine and preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 不同酸化剂类型对断奶仔猪生产性能及腹泻的影响;朱碧泉等;《饲料工业》;20110725(第14期);21-23 * |
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