KR101949481B1 - The composition of feed consumption improver, and method for manufacturing thereof - Google Patents

Abstract

The present invention relates to a feed intake enhancing agent and a method for manufacturing the same, which are capable of effectively recovering or enhancing a feed intake amount by adding the feed intake enhancing agent to feed of livestock with reduced appetite due to a disease or stress, promoting growth of the livestock, and improving productivity. The feed intake enhancing agent is formed by mixing 0.1-1 wt% of cyproheptadine, 5-50 wt% of a magnesium oxide, 10-20 wt% of calcium carbonate, and 29-84.4 wt% of wheat shorts.

Description

Technical Field [0001] The present invention relates to a feed intake enhancer composition,

The present invention relates to a feed intake enhancer composition, and more particularly to a feed intake enhancer composition, and more particularly, to an animal feed supplement composition containing the present feed intake composition and feeding the animal feed composition, Or to increase the growth and health of livestock, and a method for producing the same.

The purpose of the livestock industry is to breed livestock such as chickens, pigs, cows, and produce livestock products such as eggs, meat, and milk to promote human health. In recent years, as the demand for livestock products has increased, the scale of livestock industry has also been enlarged and specialized, and as imports and exports of livestock products among nations have been liberalized, efforts to increase productivity and secure competitiveness have been demanded more.

In recent years, one of the feed additives that are in the limelight for improving the productivity is the feed intake enhancer. Fodder additives, sweeteners, and acidifiers have been used as feed enhancers to increase the feed intake by increasing the feed intake by feeding the fodder to the livestock.

Feed intake is an important indicator of the productivity improvement of livestock. By increasing the feed intake to the livestock, more livestock products can be obtained within a short period of time. These feed intakes are affected by various factors such as livestock health, breeding environment, age and sex, feed quality and palatability. In particular, in order to maintain the quality and palatability of the feed, fresh and flavorful raw materials must be used. This leads to an increase in feed price and lowers price competitiveness. Therefore, the farm or feed factory prefers to use inexpensive by- have. Therefore, flavorings, sweeteners and acidifiers have been added to diets for the purpose of improving productivity by optimizing or maximizing the feed intake of livestock as an economic animal. By appropriately using these feed intake enhancers, it is possible to increase the use rate of by-products having low palatability due to low price and low freshness and flavor, so that it is possible to design economically for feed composition and increase the feed intake, Can be achieved.

Most of these formulations have been used continuously as feed additives by adding 0.01 to 0.1% to the compound feed, but the addition effect is decreased due to the acquisition of tolerance by continuous feeding. That is, the threshold value is increased due to the continued use of flavorings, sweeteners, and acidifiers, and there is a problem that the usage amount must be continuously increased to obtain an expected effect.

In addition, the physiological phenomenon caused by the loss of food intake caused by anorexia in a certain period (summer high temperature, when the disease occurs, when weaning, when moving, feed, etc.) There is a problem that the feed intake can not be restored or increased even if the sweetness or acidity increases the palatability of the feed.

Recent studies have shown that the reduction of feed intake at the particular time periods described above is the greatest obstacle to improving the overall productivity of livestock, so that the feed intake can be restored or improved by appropriate methods at this particular time, .

The addition of conventional feed intake enhancers such as flavorings, sweeteners, or acidifiers to feeds during periods of high temperature in summer or during illness, or during stressful periods such as reason and movement, The effect is very limited. In particular, it is difficult to expect a satisfactory result even if a feed intake enhancer is added to a feed to feed a feedstuff due to disease infection or severe high temperature stress.

In order to solve the above-mentioned problems, Korean Patent No. 10-1550354 discloses a method for improving the physiological function of livestock to improve the feed intake of livestock, which is greatly reduced in feed intake due to diseases or stress, The present invention relates to a feed intake enhancing and growth promoting composition comprising an agricultural horticultural extract and a cyproheptadine dispersion as effective ingredients, and a method for producing the same. However, a complicated manufacturing process and a lot of time are required for producing a horseradish extract and a cyproheptadine dispersion Therefore, it is not economical to apply to economical animals such as chickens, pigs, cattle, etc., and thus there is a problem in commercialization.

Patent Document 1: Korean Patent Registration No. 10-0528313 Patent Document 2: Korean Patent Registration No. 10-0880915 Patent Document 3: Korean Patent Publication No. 10-1550354

Accordingly, the present invention was developed to solve the problems of the conventional feed intake enhancer as described above. In order to increase the feed intake of livestock, which is significantly reduced in feed intake due to diseases and stress, The present invention has been made in order to provide a feed intake enhancer composition capable of being commercialized and a method for producing the same.

In order to achieve the above object, the present invention relates to a method for preparing a magnesium alloy powder, which comprises adding 8 to 10% by weight of magnesium oxide to a mixer, dissolving 0.3 to 0.7% by weight of ciproheptadine, slowly injecting it into magnesium oxide for 20 minutes while stirring at 60 rpm, 88 to 90% by weight of calcium carbonate are put into a mixer and mixed at a speed of 120 rpm for 10 to 30 minutes.
In the present invention, 8 to 10% by weight of magnesium oxide is added to a mixer, 0.3 to 0.7% by weight of ciproheptadine is dissolved, and 88 to 90% by weight of dried dried components, which are slowly injected into magnesium oxide for 20 minutes with stirring at 60 rpm, And then mixed at a speed of 120 rpm for 10 to 30 minutes.

The present invention relates to a method for producing magnesium oxide, comprising: loading 5.0 to 50.0% by weight of magnesium oxide into a powder mixer; Dissolving 0.1 to 1.0% by weight of ciproheptadine in ethanol having a weight five times the weight of cyproheptadine; Adsorbing the dissolved solution while spraying the magnesium oxide; 10.0 to 20.0% by weight of calcium carbonate and 29.0 to 84.4% by weight of dried horse powder (rice husk powder) are put into a mixer and mixed to form a composition.
In the present invention, 8 to 10% by weight of magnesium oxide is added to a mixer, 0.3 to 0.7% by weight of ciproheptadine is dissolved in 1 to 2% by weight of ethanol and slowly injected into magnesium oxide for 20 minutes with stirring at 60 rpm for adsorption 88 to 90% by weight of calcium carbonate are added to a mixer and mixed at a rate of 120 rpm for 10 to 30 minutes.
In the present invention, 8 to 10% by weight of magnesium oxide is added to a mixer, 0.3 to 0.7% by weight of ciproheptadine is dissolved in 1 to 2% by weight of ethanol and the mixture is slowly sprayed onto magnesium oxide for 20 minutes while stirring at 60 rpm, And 88 to 90% by weight of the blend is added to the mixer, followed by mixing at a speed of 120 rpm for 10 to 30 minutes.

As described above, by providing the feed intake enhancer composition of the present invention and the method for preparing the same, it is possible to economically and effectively recover or enhance the feed intake by feeding the feed to the feed with reduced appetite due to diseases or stress, And it is possible to enhance the productivity and the productivity.

Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

The feed intake enhancer according to the present invention comprises ciproheptadine and magnesium oxide as an active ingredient and is composed of a composite composition composed of ciproheptadine, magnesium oxide, calcium carbonate and dried horse powder, In addition, it is possible to solve the problem of existing products that the feed intake enhancement effect is insufficient or the economical efficiency is lowered by feeding to the feed during certain periods such as high temperature in summer or disease,

Cyproheptadine, which is used as a main component in the present invention, is a dibenzocycloheptene piperidine antihistamine agent, which is used in the field of human body to treat various skin pruritus, dermatitis, eczema, allergic rhinitis, It is used for the treatment of dyspepsia, vasomotor edema, etc. It is also used for the treatment of anorexia and weight loss. The antihistamine pharmacogenetic mechanism of cyproheptadine is that the sprouted heptadine binds to the histamine H1 receptor and exhibits an antihistamine effect. Ciproheptadine competitively inhibits the action of serotonin.

In other words, serotonin binds to the 5-HT2C serotonin receptor in the satiety center and feels fullness. Ciproheptadine binds to the satiety center instead of serotonin to inhibit the action of serotonin, so that the feeling of satiety is lessened. It is a role to help.

Magnesium oxide used as a main component in the present invention is a kind of a large amount of minerals that catalyzes hundreds of biological reactions in mitochondria and plays an essential role in cell respiration. In addition, it accelerates the digestion and absorption of nutrients by activating various enzymes in all energy metabolism process. Especially, it is possible to innovatively improve the feed intake enhancement effect by the synergistic action in combination with cyproheptadine.

Calcium carbonate used as an excipient in the present invention is a dry and pulverized powder obtained by blanching carbon dioxide in lime oil. The powder is dried and pulverized, and has no reactivity with the active ingredients. The calcium carbonate is insoluble without stimulating the digestive organs, It is used as an excipient for additives.

Dried wheat shorts used as an excipient in the present invention is a powder obtained by removing wheat flour from the milling process and drying the by-products remaining in the sieve, and has no reactivity with the active ingredients, has no side effects on the digestive organs, It is used as an excipient for additives.

Ciproheptadine used as a main component in the present invention preferably contains 0.1 to 1.0 wt% based on the weight of the total composition.

When the amount of ciproheptadine is less than 0.1 wt%, the effect of improving feed intake is insufficient. When the amount of cipro heptadine is more than 1.0 wt%, the cost is higher than the effect, so it is not preferable to apply it to cattle that are economical animals.

The magnesium oxide used as a main component in the present invention is preferably used in an amount of 5.0 to 50.0% by weight based on the weight of the entire composition.

When the amount of the magnesium oxide is 5.0 wt% or less, the effect of improving the feed intake is insufficient, and when the magnesium oxide is 50.0 wt% or more, it is not preferable because of excessive use.

The calcium carbonate, which is an excipient in the feed intake enhancer composition according to the present invention, is preferably used in an amount of 10.0 to 20.0% by weight based on the weight of the whole composition.

If the amount of the calcium carbonate is less than 10.0% by weight, the stability of the composition may be deteriorated. If the amount of the calcium carbonate is more than 20.0% by weight, stability of the composition may be deteriorated.

It is preferable that the dry fraction used as the excipient used in the present invention is 29.0-84.4 wt% based on the weight of the whole composition.

If the amount of the dried horse parts is less than 29.0% by weight, the stability (uniformity) of the composition may be deteriorated. If the amount is more than 84.4% by weight, the stability of the composition may be deteriorated.

The method of preparing the feed intake enhancer composition according to the present invention is as follows. For example, 5.0 to 50.0% by weight of magnesium oxide is placed in a mixer, and 0.1 to 1.0% by weight of cyproheptadine is dissolved in an amount of ethanol five times the weight of cyproheptadine and dissolved. The solution is stirred at a rate of 20 rpm Minute magnesium oxide for adsorption, 10.0-20.0% by weight of calcium carbonate and 29.0-84.4% by weight of dried latex are put into a mixer and mixed at a rate of 120 rpm for 10-30 minutes to form a composition.

The present invention can be understood more specifically by the following examples and experimental examples, and it is to be understood that the following examples are intended to illustrate the present invention and are not intended to limit the scope of the present invention.

[Comparative Example 1]

The feed intake enhancer composition (Comparative Example 1) is prepared from the ingredients shown in Table 1 below.

ingredient In 1kg  Sansa extract 5g Ciproheptadine dispersion 80g Liquid paraffin 20g Zeolite 400g Roasted rice husk powder 495g

The process for preparing the feed enhancing agent composition is as follows.

First, 250 g of dried persimmon leaves are added to 1,000 ml of 70% ethanol, and 20 g of elvan is added. The leaves are left to stand for 3 ~ 7 days at room temperature, and then filtered with 20 mesh sieve.

In the second step, 100 ml of anhydrous ethanol and 100 g of polyethylene glycol-400 were added to the stirring tank and stirring was started at 120 rpm. 11 g of pro-heptane hydrochloride was added thereto and stirred for 60 minutes to completely dissolve. 10 g of polysorbate 80 The stirring speed is lowered to 30 rpm and stirred for 30 minutes to prepare a ciproheptadine solution. 99 g of silicon dioxide was added to the powder mixer, and a ciproheptadine solution was sprayed while the mixer was operated at a speed of 30 rpm. When the adsorbate was completed, it was dried in an 80 hot air drier for 2 hours and pulverized by a pulverizer to obtain a dispersion containing 5% Sieve.

0.5% by weight of the crustacea extract prepared in the first step, 8.0% by weight of ciproheptadine dispersion prepared in Step 2, 40.0% by weight of zeolite and 49.5% by weight of baked rice hull powder were put into a mixer, And mixing the mixture at a rate of 120 rpm for 10 to 30 minutes while spraying the mixture to prepare a feed intake enhancer composition.

A feed intake enhancer composition (Example 1) is prepared from the ingredients in Table 2 below.

ingredient In 1kg Ciproheptadine 4g Magnesium oxide 100g Calcium carbonate 120g Dry matter 776 g

The process for preparing the feed enhancing agent composition is as follows. Magnesium oxide was added to the mixer, ciproheptadine was dissolved in 20 g of ethanol, and the mixture was slowly sprayed onto magnesium oxide for 20 minutes while stirring at 60 rpm. After the calcium carbonate and the dried powder were introduced into the mixer, For 30 minutes to prepare a feed intake enhancer composition.

A feed intake enhancer composition (Example 2) is prepared from the ingredients in Table 3 below.

ingredient In 1kg Ciproheptadine 4g Calcium carbonate 120g Dry matter 876g

The process for preparing the feed enhancing agent composition is as follows. Cipro heptadine, calcium carbonate, and dry horse chestnuts are sequentially added to a mixer and then mixed at a rate of 120 rpm for 10 to 30 minutes to prepare a feed intake enhancer composition.

A feed intake enhancer composition (Example 3) is prepared from the ingredients in Table 4 below.

ingredient In 1kg Magnesium oxide 100g Calcium carbonate 120g Dry matter 780g

The process for preparing the feed enhancing agent composition is as follows. Magnesium oxide, calcium carbonate, and dry horse chestnut are sequentially added to a mixer, and then mixed at a rate of 120 rpm for 10 to 30 minutes to prepare a feed intake enhancer composition.

A feed intake enhancer composition (Example 3) is prepared from the ingredients in Table 5 below.

ingredient In 1kg Ciproheptadine 4g Magnesium oxide 100g Calcium carbonate 896g

The process for preparing the feed enhancing agent composition is as follows. Magnesium oxide was added to the mixer, ciproheptadine was dissolved in 20 g of ethanol, and the mixture was slowly sprayed onto magnesium oxide for 20 minutes while stirring at 60 rpm. After the calcium carbonate was added to the mixer, the mixture was mixed at a rate of 120 rpm for 10 to 30 minutes To produce a feed intake enhancer composition.

A feed intake enhancer composition (Example 5) is prepared from the ingredients in Table 6 below.

ingredient In 1kg Ciproheptadine 4g Magnesium oxide 100g Dry matter 896g

The process for preparing the feed enhancing agent composition is as follows. Magnesium oxide was added to the mixer, ciproheptadine was dissolved in 20 g of ethanol, and slowly injected into magnesium oxide for 20 minutes while stirring at a speed of 60 rpm. The dried dried powder was adsorbed to the mixer and mixed at a rate of 120 rpm for 10 to 30 minutes. To prepare an absorption enhancer composition.

Kinds Feed intake enhancer composition Comparative Example 1 Horseradish extract + cyproheptadine + liquid paraffin + zeolite + baked rice husk powder Example 1 Cipro heptadine + magnesium oxide + calcium carbonate + dry powder Example 2 Cipro heptadine + Calcium carbonate + dried powder Example 3 Magnesium oxide + Calcium carbonate + dried powder Example 4 Cipro Heptadine + Magnesium Oxide + Calcium Carbonate Example 5 Cipro heptadine + magnesium oxide + dried horse chestnut

Composition of feed intake enhancer composition

[Experimental Example 1] Effect of Feed Intake Enhancement Experiment

1. Experimental Method

3-4 weeks of appetite deterioration due to long-distance movement. Weeds (Yorkshire F-1, male) 150

(30 days) were divided into five groups, each of which was divided into four groups. Each of the four test groups was supplemented with 0.1% of the composition of Comparative Example 1 and Examples 1, 2 and 3, In the group, only the compound diet was fed as a control. Total feed intake, body weight gain and feed conversion ratio were measured from the start of the test to the end of the test.

2. Experimental results

The feeding efficiency of the feed of Example 1 was the highest. 20.1% increase compared to the control group without the treatment and 5.7% increase compared to the control group 1. And 11.9% and 14.5%, respectively, as compared with Example 2 in which ciproheptadine alone was used as the main ingredient and Example 3 in which magnesium oxide alone was used as the main ingredient, thereby increasing the feed intake of ciproheptadine and magnesium oxide (Comparative Example 1) described in Korean Patent Registration No. 10-1550354, the manufacturing method is very simple and the manufacturing time is greatly shortened, and the manufacturing cost can be remarkably reduced, But also greatly improved in terms of.

The amount of feed intake, the amount of gain, and the feed conversion ratio of each composition are shown in Table 8 below.

Kinds Average daily feed intake per person Average daily gain per day Feed rate Control 1,235.7 g 523.6 g 2.36 Comparative Example 1 1,403.6g 635.1 g 2.21 Example 1 1,483.6g 674.4 g 2.20 Example 2 1,325.7 g 594.5 g 2.23 Example 3 1,295.9 g 561.0 g 2.31

[Experimental Example 2] Stability test

1. Experimental Method

To evaluate the stability of each composition, 100 kg of each composition was prepared and packed into 5 kg of vial packaging in a package of 5 pieces. After storage for 12 months at room temperature, samples were taken from the top, middle and bottom of the packaging paper, And the content thereof was measured.

2. Experimental results

The compositions of Examples 1 and 3 were in a good state of uniformity maintenance and the content of active ingredient was very stable for each sample, but the uniformity of Examples 2, 4 and 5 was poor. It can be seen that the stability is excellent when cyproheptadine, which is a main ingredient, is dissolved in ethanol and adsorbed on magnesium oxide, and calcium carbonate and dry horse meal are mixed with excipient.

The uniformity and the active ingredient content of each Example composition are shown in Table 9 below.

Kinds Mixed state maintenance state Ciproheptadine content (%) Magnesium content (%) Prize medium Ha Prize medium Ha Example 1 Good 98.9% 99.3% 99.7% 99.2% 99.4% 100.1% Example 2 Bad 78.3% 87.9% 105.7% - - - Example 3 Good - - - 98.7% 101.2% 98.8% Example 4 Bad 96.4% 89.4% 102.3% 97.2% 88.5% 103.8% Example 5 Bad 86.1% 98.6% 103.4% 87.2% 99.1% 104.1%

Meanwhile, as another embodiment of the present invention, a ruminant refers to an animal group that eats for easy digestion and nutrition.

Cows, which are typical animals of ruminants, are usually divided into four chambers, and the rumen functions as the first and second largest beehive.

There are more than 10 billion microorganisms per ml of gastric juice in the rumen of cattle, and they are nutritionally active.

Especially, in the case of animals such as cows, it is important to mix the feed intake enhancer composition with the yellow clay block to make the microbes smoothly multiply and metabolism activity to make the rumen rumen etc. to maximize cattle nutritional activity.

For this purpose, the loess block includes 80 wt% to 90 wt% of loess, 10 wt% to 20 wt% of minerals, and 10 wt% to 20 wt% of vitamins.

Examples of the minerals include Ba, Co, Cr, Cu, Li, Nb, Ni, Sc, Sr, V, Y, Zn, Zr, La, Ce, Nd, Sm, Eu, Dy, Yb and Rb.

Therefore, if the feed intake enhancer composition is mixed with the feed, even the feed is susceptible to not eating. However, when the oat block containing the present invention is made, it is well licked.

In addition, a feed intake enhancer composition, which can be ingested by loess blocks, can be easily provided around the cattle, thereby enabling rapid growth due to the increased feed intake of the ruminant in breeding.

In the above-mentioned example, a culture medium of Bacillus sp. Bacteria, a culture medium of Rhodopseudomonas sp. Photosynthetic bacteria, a culture medium of Lactobacillus sp. Lactic acid bacteria, and a culture medium of Saccaromyces sp. . ≪ / RTI >

As described above, the feed intake enhancer composition according to the present invention and the method for preparing the same can economically and effectively recover or enhance the feed intake by feeding the feed to the feed with reduced appetite due to diseases or stress, And can improve productivity.
In an embodiment of the present invention, 8 to 10% by weight of magnesium oxide is added to a mixer, 0.3 to 0.7% by weight of ciproheptadine is dissolved in 1 to 2% by weight of ethanol and slowly sprayed into magnesium oxide for 20 minutes with stirring at a speed of 60 rpm And then 88 to 90% by weight of calcium carbonate is added to the mixer, followed by mixing at a rate of 120 rpm for 10 to 30 minutes.
In an embodiment of the present invention, 8 to 10% by weight of magnesium oxide is added to a mixer, 0.3 to 0.7% by weight of ciproheptadine is dissolved in 1 to 2% by weight of ethanol and slowly sprayed into magnesium oxide for 20 minutes with stirring at a speed of 60 rpm And 88 to 90% by weight of the dried dried horse parts are put into a mixer and mixed at a rate of 120 rpm for 10 to 30 minutes.

Claims (7)

8 to 10% by weight of magnesium oxide was added to the mixer, 0.3 to 0.7% by weight of ciproheptadine was dissolved in 1 to 2% by weight of ethanol and slowly injected into magnesium oxide for 20 minutes while stirring at 60 rpm for adsorption. To 90% by weight of the mixture is added to a mixer, and the mixture is mixed at a speed of 120 rpm for 10 to 30 minutes to prepare a feed enhancing agent. 8 to 10% by weight of magnesium oxide was added to a mixer, 0.3 to 0.7% by weight of ciproheptadine was dissolved in 1 to 2% by weight of ethanol, and the mixture was slowly sprayed onto magnesium oxide for 20 minutes while stirring at 60 rpm, To 90% by weight of the mixture is added to a mixer, and the mixture is mixed at a speed of 120 rpm for 10 to 30 minutes to prepare a feed enhancing agent.
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