KR101550354B1 - The composition of feed consumption improver and growth promotor, and method for manufacturing thereof - Google Patents

Abstract

Provided are a composition for enhancing feed intake and promoting growth, and a manufacturing method thereof. The composition of the present invention is capable of effectively recovering or enhancing the amount of feed intake, promoting growth of livestock, and improving productivity as the composition is added to feed and providing for livestock with reduced appetite due to disease or stress, etc. To this end, the composition is formed by mixing 0.2-5.0 wt% of a Crataegus pinnatifida bunge extract, 2.0-20.0 wt% of a cyproheptadine dispersion body, 1.0-5.0 wt% of liquid paraffin, 25.0-50.0 wt% of zeolite, and 25.0-71.8 wt% of baked bran powder.

Description

FIELD OF THE INVENTION The present invention relates to a feed enhancing and growth promoting composition,

The present invention relates to a feed intake enhancing and growth promoting composition, and more particularly, to a feed intake enhancing and growth promoting composition comprising a feed enhancing and growth promoting agent composition for feeding a feed consumed by a livestock and reducing the appetite due to diseases and stress, The present invention relates to a composition for enhancing feed intake and growth and a method for preparing the same, which can improve the growth and health of livestock by restoring or increasing the feed intake of the livestock.

The purpose of the livestock industry is to breed livestock such as chickens, pigs, cows, and produce livestock products such as eggs, meat, and milk to promote human health. In recent years, as the demand for livestock products has increased, the scale of livestock industry has also been enlarged and specialized, and as imports and exports of livestock products among nations have been liberalized, efforts to increase productivity and secure competitiveness have been demanded more.

One of the products that are in the limelight for improving the productivity recently is the feed intake enhancer. Fodder additives, sweeteners, and acidifiers have been used as feed enhancers to increase the feed intake by increasing the feed intake by feeding the fodder to the livestock.

Feed intake is an important indicator of the productivity improvement of livestock. By increasing the feed intake to the livestock, more livestock products can be obtained within a short period of time. These feed intakes are affected by various factors such as livestock health, breeding environment, age and sex, feed quality and palatability. In particular, in order to maintain the quality and palatability of the feed, fresh and flavorful raw materials must be used. This leads to an increase in feed price and lowers price competitiveness. Therefore, the farm or feed factory prefers to use inexpensive by- have. Therefore, some flavors, sweeteners and acidifiers have been added to diets for the purpose of improving productivity by optimizing or maximizing the feed intake of livestock as an economic animal. By appropriately using these feed intake enhancers, it is possible to increase the use rate of by-products having low palatability due to low price and low freshness and flavor, so that it is possible to design economically for feed composition and increase the feed intake, Can be achieved.

Most of these formulations have been used continuously as feed additives by adding 0.01 to 0.1% to the compound feed, but the addition effect is decreased due to the acquisition of tolerance by continuous feeding. That is, the threshold value is increased due to the continued use of flavorings, sweeteners, and acidifiers, and there is a problem that the usage amount must be continuously increased to obtain an expected effect.

In addition, the physiological phenomenon caused by the loss of food intake caused by anorexia in a certain period (summer high temperature, when the disease occurs, when weaning, when moving, feed, etc.) There is a problem that the feed intake can not be restored or increased even if the sweetness or acidity increases the palatability of the feed.

Recent studies have shown that the reduction of feed intake at the particular time periods described above is the greatest obstacle to improving the overall productivity of livestock, so that the feed intake can be restored or improved by appropriate methods at this particular time, .

The addition of conventional feed intake enhancers such as flavorings, sweeteners, or acidifiers to feeds during periods of high temperature in summer or during illness, or during stressful periods such as reason and movement, The effect is very limited. In particular, it is difficult to expect a satisfactory result even if a feed intake enhancer is added to a feed to feed a feedstuff due to disease infection or severe high temperature stress.

Therefore, in order to increase the feed intake of livestock, which is greatly reduced in feed intake due to disease or stress, it is necessary to improve the physiological function of the livestock rather than increasing the feed intake to increase the palatability of the feed, Is effective.

Patent Document 1: Korean Patent Registration No. 10-0528313 Patent Document 2: Korean Patent Registration No. 10-0880915

Accordingly, the present invention was developed to solve the problems of the conventional feed intake enhancer as described above. In order to increase the feed intake of the livestock having a significantly reduced feed intake due to disease or stress, the feed intake An improvement and a growth promoter composition and a manufacturing method thereof.

In order to attain the above object, the present invention provides a method for producing chopped rice husk powder, comprising the steps of: 0.2 to 5.0% by weight of Crassostyle extract, 2.0 to 20.0% by weight of ciproheptadine dispersion, 1.0 to 5.0% by weight of liquid paraffin, 25.0 to 50.0% by weight of zeolite, And 25.0 to 71.8% by weight of the total weight of the composition.

In addition, the present invention provides a method for preparing a crude extract of the present invention, comprising the steps of: (1) adding dry crushed silica powder to a 70% ethanol solution, adding elvan stone, extracting the mixture at room temperature for 3 to 7 days, A second step of dissolving cyproheptadine in a mixed solution of ethanol, polyethylene glycol and polysorbate 80 and adsorbing it onto silicon dioxide to prepare a cyproheptadine dispersion; 0.2 to 5.0% by weight of cinnabar extract, 2.0 to 20.0% by weight of ciproheptadine dispersion, 1.0 to 5.0% by weight of liquid paraffin, 25.0 to 50.0% by weight of zeolite and 25.0 to 71.8% by weight of baked rice hull powder, And then mixing the resultant mixture to form a composition.

As described above, the feed intake enhancing and growth promoting composition of the present invention and the method for preparing the same can provide the feed intake of the animal having decreased appetite due to disease or stress, Thereby promoting the growth of the livestock and improving the productivity.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a block diagram showing a process for producing a composition according to the present invention. FIG.

Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

The feed enhancing and growth promoting agent according to the present invention is composed of a composite composition comprising an agricultural horticultural extract and cyproheptadine as an active ingredient, and in particular, a horseradish extract, cyproheptadine, zeolite, liquid paraffin and baked rice husk powder , Feeding in the feed at a certain time such as high temperature in the summer when the feed intake is decreased, disease occurrence, reason, movement and stress, etc., can solve the problem of the existing products that the feed intake enhancement effect is insufficient.

The Crataegus pinnatifida bunge dried fruit, which is used as a main component in the present invention, is obtained by extracting dried fruit of Crataegus pinnatifida bunge with ethanol or water, filtering the solution by concentrating under reduced pressure and promoting the secretion of various digestive enzymes, It has been used for dyspepsia, enteritis, hepatitis, jaundice and hypertension in the field of human body because it has excellent enhancing effect and strengthens the anti-illness effect and has an excellent effect of inhibiting liver cancer and lowering blood pressure.

The cyproheptadine used as a main component in the present invention is a dibenzocycloheptene piperidine antihistamine agent. In the human field, various kinds of skin pruritus, dermatitis, eczema, allergic rhinitis , Dyspepsia, vasomotor edema, and the like, and is also used for the treatment of anorexia and weight loss. The antihistamine pharmacogenetic mechanism of cyproheptadine is that the sprouted heptadine binds to the histamine H1 receptor and exhibits an antihistamine effect. Ciproheptadine competitively inhibits the action of serotonin.

In other words, serotonin binds to the 5-HT2C serotonin receptor in the satiety center and feels fullness. Ciproheptadine binds to the satiety center instead of serotonin to inhibit the action of serotonin, so that the feeling of satiety is lessened. It is a role to help.

The zeolite used as an excipient in the present invention is an alkali and alkaline earth metal silicate of aluminum hydrate which does not cause physical and chemical reaction with the active ingredients and has excellent preservability and is low in humidity and is used as an excipient for feed additives in order to maintain stability .

The baked rice hull powder used as an excipient in the present invention is a powder obtained by calcining rice hull and then pulverized to a size of 50 to 100 mesh. It does not induce a physical and chemical reaction with active ingredients and has excellent preservability and low moisture content, Is used as an excipient.

Liquid paraffin used as a stabilizer in the present invention is a mixture of hydrocarbons obtained from petroleum, which is colorless, odorless and tasteless. Therefore, it does not affect the active ingredient and improves the mixing degree and uniformity in the production of feed additive, Is used as an additive.

It is preferable that the dry season extract which is a main component used in the present invention is used in an amount of 0.2 to 5.0% by weight based on the weight of the whole composition.

When the crustacea extract is contained in an amount of 0.2 wt% or less, the effect of promoting feed intake and growth is insufficient. When the crustacean extract is 5.0 wt% or more, economical efficiency is deteriorated.

It is preferable that cyproheptadine, which is a main component of the feed intake enhancing and growth promoter composition, is contained in an amount of 0.1 to 1.0 wt% based on the weight of the total composition.

When the amount of ciproheptadine is less than 0.1 wt%, the effect of enhancing the feed intake and promoting growth is insufficient. If the cipro heptadine is 1.0 wt% or more, the cost is higher than the effect, so it is not preferable to apply it to cattle that are economical animals.

The liquid paraffin, which is a stabilizer used in the present invention, is preferably used in an amount of 1.0 to 5.0% by weight based on the weight of the entire composition.

When the liquid paraffin is 1.0 wt% or less, the stability of the composition is deteriorated. When the liquid paraffin is 5.0 wt% or more, excessive use of the paraffin is not preferable.

The feed enhancing and growth promoting composition according to the present invention is preferably used in an amount of 25.0 to 50.0% by weight, based on the weight of the whole composition, as an excipient.

When the zeolite content is 25.0% by weight or less, the stability of the composition is maintained (uniformity is maintained). When the zeolite content is 50.0% by weight or more, the stability of the composition is deteriorated.

The baked rice husk powder, which is an excipient used in the present invention, is preferably used in an amount of 25.0 to 71.8% by weight based on the weight of the whole composition.

When the baked rice husk powder is not more than 25.0 wt%, the stability of the composition is maintained (uniformity is maintained), and when the baked rice husk powder is not less than 71.8 wt%, the stability of the composition is deteriorated.

The method of preparing a feed enhancing and growth promoting composition according to the present invention is as follows.

The first step (S100) is a step of preparing an extract of horseshoe crab, wherein 250 g of dried seaweed is cut into 1,000 ml of 70% ethanol, and 20 g of elvan is put therein and left at room temperature for 3 to 7 days. And then concentrated under reduced pressure to prepare an antler extract.

In this case, the extraction time is preferably 3 to 7 days in the first step (S100), and the extracting condition is unsatisfactory for 3 days or less, and is not preferable because it is no longer extracted for 7 days or more .

The second step 200 is a step of preparing a ciproheptadine dispersion to improve the mixing, uniformity and bioavailability of cyproheptadine, wherein 100 ml of anhydrous ethanol and 200 ml of polyethylene glycol-400 And stirring was started at a rate of 120 rpm. 11 g of pro-heptane hydrochloride was added thereto and stirred for 60 minutes to completely dissolve. Then, 10 g of Polysorbate 80 was added, the stirring speed was reduced to 30 rpm and the mixture was stirred for 30 minutes After preparing a solution of cyproheptadine, 99 g of silicon dioxide was added to a powder mixer, and a ciproheptadine solution was sprayed while the mixer was operated at a speed of 30 rpm. When the adsorbate was completed, the mixture was dried in a hot air drier at 80 ° C. for 2 hours, Thereby completing the cipro heptadine dispersion.

In this case, it is preferable to use 30.0 to 60.0% by weight based on the weight of the anhydrous ethanol and the silver cryptosulfate solution in the step of preparing the cipro heptadine dispersion in the second step (S200), and when it is 30.0% by weight or less The dissolution of ciproheptadine is insufficient, and when it is 60.0% by weight or more, the use amount of polyethylene glycol 400 is relatively decreased, and the ciproheptadine dissolution effect is insufficient.

In the second step (S200), in the step of preparing the cipro heptadine dispersion, the polyethylene glycol 400 is preferably used in an amount of 25.0 to 62.5 wt% based on the weight of the total ciproheptadine solution, and in the case of 25.0 wt% If ciproheptadine is insufficient in dissolving effect, the amount of anhydrous ethanol is relatively decreased and the dissolution of ciproheptadine is insufficient, which is not preferable.

The polysorbate 80 is preferably used in an amount of 2.5 to 10.0% by weight based on the total weight of the ciproheptadine solution in the step of preparing the cipro heptadine dispersion in the second step S200, If the stability of heptadine is lowered and more than 10% by weight, excessive use is not preferable.

The third step (S300) is a step of preparing the final composition, wherein 0.2 to 5.0% by weight of the crustacea extract prepared in the first step (S100) and the cipro heptadine dispersion prepared in the second step (S200) , 25.0 to 50.0% by weight of zeolite, 20.0 to 71.8% by weight of baked rice husk powder, and 1.0 to 5.0% by weight of liquid paraffin are sprayed at 120 rpm for 10 to 30 minutes to form a composition .

The present invention can be understood more specifically by the following examples and experimental examples, and it is to be understood that the following examples are intended to illustrate the present invention and are not intended to limit the scope of the present invention.

The feed intake enhancing and growth promoter composition is prepared from the ingredients shown in Table 1 below.

ingredient In 1kg  Sansa extract 5g Ciproheptadine dispersion 100g Liquid paraffin 20g Zeolite 400g Roasted rice husk powder 475g

The process for enhancing feed intake and growth promoter composition is as follows. Zeolite, and baked rice husk powder are sequentially added to a mixer, and then liquid paraffin is sprayed while mixing at a rate of 120 rpm for 10 to 30 minutes to prepare a feed intake enhancing and growth promoter composition.

Feed enhancing and growth promoter compositions are prepared from the following Table 2 ingredients.

ingredient In 1kg Sansa extract 5g Liquid paraffin 20g Zeolite 400g Roasted rice husk powder 475g

The process for enhancing feed intake and growth promoter composition is as follows. Zeolite and roasted rice husk powder are sequentially added to a mixer and mixed with liquid paraffin at a rate of 120 rpm for 10 to 30 minutes to prepare a feed intake enhancing and growth promoter composition.

Feed enhancing and growth promoter compositions are prepared from the following Table 3 ingredients.

ingredient In 1kg Ciproheptadine dispersion 100g Liquid paraffin 20g Zeolite 400g Roasted rice husk powder 475g

The process for enhancing feed intake and growth promoter composition is as follows. Zeolite, and baked rice husk powder are sequentially added to a mixer, and then mixed with liquid paraffin at a rate of 120 rpm for 10 to 30 minutes to prepare a feed intake enhancing and growth promoter composition.

Feed enhancing and growth promoter compositions are prepared from the ingredients in Table 4 below.

ingredient In 1kg Sansa extract 5g Ciproheptadine dispersion 100g Zeolite 400g Roasted rice husk powder 475g

The process for enhancing feed intake and growth promoter composition is as follows. Zeolite, and baked rice husk powder are sequentially added to a mixer, and then mixed at a rate of 120 rpm for 10 to 30 minutes to prepare a feed intake enhancing and growth promoter composition.

Feed enhancing and growth promoter compositions are prepared from the following Table 5 ingredients.

ingredient In 1kg Sansa extract 5g Ciproheptadine dispersion 100g Liquid paraffin 20g Roasted rice husk powder 475g

The process for enhancing feed intake and growth promoter composition is as follows. The mixture of horseradish extract, ciproheptadine and roasted rice hull powder is put into each mixer in order and mixed with liquid paraffin at 120 rpm for 10 to 30 minutes to prepare a feed intake enhancing and growth promoter composition.

Feed enhancing and growth promoter compositions are prepared from the following Table 6 ingredients.

ingredient In 1kg Sansa extract 5g Ciproheptadine dispersion 100g Liquid paraffin 20g Zeolite 400g

The process for enhancing feed intake and growth promoter composition is as follows. And a mixture of cyanobacterium extract, ciproheptadine dispersion and zeolite are sequentially injected into a mixer, and liquid paraffin is injected thereinto at 120 rpm for 10 to 30 minutes to prepare a feed intake enhancing and growth promoter composition.

Composition of feed intake enhancer composition Kinds Feed intake enhancement and growth promoter composition Example 1 Horseradish extract + cyproheptadine + liquid paraffin + zeolite + baked rice husk powder Example 2 Sansa extract + liquid paraffin + zeolite + baked rice husk powder Example 3 Cipro heptadine + liquid paraffin + zeolite + baked rice husk powder Example 4 Crustacea extract + Cipro heptadine + Zeolite + Roasted rice husk powder Example 5 Crustacea extract + Ciproheptadine + Liquid paraffin + Roasted rice husk powder Example 6 Crustacea extract + Ciproheptadine + Liquid paraffin + Zeolite

[Experimental Example 1] Feed intake and growth promoting effect experiments

1. Experimental Method

680 9-week-old pigs with poor appetite due to long-distance movement were divided into four groups of fourteen piglets, each of which was supplemented with 0.1% of each of the first, second and third feeds for 14 weeks, As a control, only the compound diet was fed free. Total feed intake, body weight gain and feed conversion ratio were measured from the start of the test to the end of the test.

2. Experimental results

Feed intake was the highest in Example 1, which was 15.1% higher than that in the control, and 4.5% in Example 2 and 7.9% in Example 3, respectively. The weight gain was increased by 17.7% in Example 1, 5.1% in Example 2, and 8.6% in Example 3, compared with the control.

The amount of feed intake, the amount of gain, and the feed conversion ratio of each composition are shown in Table 8 below.

Kinds Average daily feed intake per person Average daily gain per day Feed rate Control 1,586g 708g 2.24 Example 1 1,825g 833g 2.19 Example 2 1,658 g 744g 2.23 Example 3 1,711 g 769 g 2.22

[Experimental Example 2] Stability test

1. Experimental Method

To examine the stability of each composition, 100 kg of each composition was prepared and packed in 5 bags of 20 kg each. After storage for 12 months at room temperature, samples were taken from the top, middle, and bottom of the bag, Were measured.

2. Experimental results

The compositions of Examples 1, 2 and 3 were well maintained in uniformity and the content of active ingredient was very stable in each sample, but the uniformity of Examples 4, 5 and 6 was poor. Also, the content of the active ingredient was greatly reduced as compared with Examples 1, 2 and 3, and the stability was poor.

The uniformity maintenance state and the effective component content of each Example composition are shown in Table 9 below.

Kinds Mixed state maintenance state Acid content Ciproheptadine content Example 1 Good 99.8% 99.2% Example 2 Good 99.5% - Example 3 Good - 99.1% Example 4 Bad 88.6% 94.6% Example 5 Bad 87.9% 89.1% Example 6 Bad 92.3% 97.2%

S100 to S300: Steps 1 to 3

Claims (5)

Which comprises as an active ingredient an extract of horseshoe crab and cyproheptadine,
The mixture is formed by mixing 0.2 to 5.0% by weight of the crustacea extract, 2.0 to 20.0% by weight of ciproheptadine dispersion, 1.0 to 5.0% by weight of liquid paraffin, 25.0 to 50.0% by weight of zeolite, and 25.0 to 71.8% ≪ / RTI > wherein the feed enhancing and growth promoting composition is a composition for enhancing feed intake and growth.
delete delete The first step is to add crushed stone powder which is dried in 70% ethanol and extract minerals at room temperature for 3 ~ 7 days, and then concentrate the filtrate under reduced pressure to produce crustacea extract;
A second step of dissolving cyproheptadine with ethanol, a mixture of polyethylene glycol-400 and polysorbate 80, and adsorbing it onto silicon dioxide to prepare a cyproheptadine dispersion;
0.2 to 5.0% by weight of cinnabar extract, 2.0 to 20.0% by weight of ciproheptadine dispersion, 1.0 to 5.0% by weight of liquid paraffin, 25.0 to 50.0% by weight of zeolite and 25.0 to 71.8% by weight of baked rice hull powder, And a third step of forming a composition by mixing the resulting mixture with a feedstock.
5. The method of claim 4,
The ciproheptadine dispersion may contain,
100 ml of anhydrous ethanol and 100 g of polyethylene glycol-400 were added to a stirring vessel, and stirring was started at 120 rpm. 11 g of pro-heptane hydrochloride was added and stirred for 60 minutes to completely dissolve. 10 g of polysorbate 80 was further added, And stirred for 30 minutes to prepare ciproheptadine solution. 99 g of silicon dioxide was added to the powder mixer, the ciproheptadine solution was sprayed while the mixer was operated at a speed of 30 rpm, and the adsorbate was completed. Dried and pulverized by a pulverizer. ≪ RTI ID = 0.0 > 8. < / RTI >

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