WO2016167502A1

WO2016167502A1 - Composition for increasing feed intake and promoting growth, and method for preparing same

Info

Publication number: WO2016167502A1
Application number: PCT/KR2016/003473
Authority: WO
Inventors: 권혁천; 채병조; 최형규; 정은용
Original assignee: 권혁천; (주)이엘티사이언스; 채병조
Priority date: 2015-04-13
Filing date: 2016-04-04
Publication date: 2016-10-20
Also published as: KR101550354B1

Abstract

The present invention is to provide a composition for increasing feed intake and promoting growth and a method for preparing the same, wherein the composition is added to a feed, which is then fed to livestock having reduced appetite due to disease or stress, thereby effectively recovering or increasing the amount of feed intake, thus promoting the growth of livestock and improving productivity. To achieve the purpose, the composition is prepared by mixing 0.2-5.0 wt% of a Crataegus pinnatifida extract, 2.0- 20.0 wt% of a cyproheptadine dispersant, 1.0-5.0 wt% of liquid paraffin, 25.0-50.0 wt% of zeolite, and 25.0-71.8 wt% of a roasted chaff powder.

Description

Feed Intake Enhancement and Growth Accelerator Compositions and Manufacturing Method Thereof

The present invention is a feed intake enhancer and growth promoter composition, more specifically, by adding the feed intake enhancer and growth accelerator composition to the feed consumed by livestock, so that the appetite is reduced due to disease and stress, feed intake is reduced The present invention relates to a feed intake enhancing and growth promoting agent composition and a method for producing the same, which are capable of restoring or increasing feed intake of livestock to promote the growth and health of the livestock.

The purpose of the livestock industry is to raise livestock such as chickens, pigs, cows, etc. to produce livestock products such as eggs, meat, and milk to promote human health. Recently, as the demand for livestock products has increased, the size of the livestock industry has also increased and specialized, and as the import and export of livestock products between countries has been liberalized, efforts to secure competitiveness by increasing productivity are required.

Recently, one of the preparations for improving productivity is a feed intake enhancer. Feed ingestion enhancers have been used to increase the food intake by feeding the palatal substances that stimulate feed intake to increase the amount of feed intake and thereby increase the productivity has been used flavors, sweeteners, acidulants and the like.

Feed intake is an important indicator for improving livestock productivity. Increasing feed intake for livestock can result in more meat and livestock products in a shorter period of time. These feed intakes are affected by a variety of factors, including the health of the livestock, the breeding environment, age and sex, and the quality and palatability of the feed. In particular, in order to maintain high quality and palatability of feed, fresh and savory raw materials should be used, which leads to an increase in feed prices and lowers price competitiveness. Therefore, farms or feed mills prefer to use inexpensive by-products. have. Therefore, some flavors, sweeteners and acidifiers are added to the feed for the purpose of improving productivity by optimizing or maximizing the feed intake of livestock, which is an economic animal. Proper use of these feed intake enhancers makes it possible to increase the ratio of by-products with low palatability but low palatability, resulting in economical design for feed blending and increased productivity through increased feed intake, resulting in increased productivity. Can achieve an improvement.

Most of these preparations have been used continuously by adding 0.01 to 0.1% to the feed compound as a feed additive, but there is a problem in that the additive effect is reduced due to the acquisition of resistance according to the continuous salary. In other words, the threshold is increased due to the continuous use of flavors, sweeteners and acidifiers and there is a problem in that the amount must be continuously increased in order to obtain the expected effect.

In addition, physiological phenomena may cause anorexia to reduce food intake at certain times (high summer season, disease occurrence, weaning, moving, feed replacement, etc.). Even if the palatability of the feed is increased by using a sweetener or an acidulant, there is a problem that the feed intake cannot be recovered or increased.

Recent studies have shown that the reduced feed intake at the specific time point above is the biggest obstacle to improving the overall productivity of the livestock, which will greatly improve productivity by restoring or improving feed intake at appropriate times. Can be.

In the summer, when feed intake decreases, or when stress occurs, such as when disease occurs, or when reason and movement, the addition of a conventional food intake enhancer such as flavoring, sweetening or acidifying agent to the feed is already reduced. For the effect is very limited. In particular, it is difficult to expect satisfactory results even if the feed intake enhancer is added to the feed, which is rarely eaten due to disease infection or severe high temperature stress.

Therefore, in order to improve the feed intake of livestock whose food intake is greatly reduced due to disease or stress, it is necessary to improve the physiological function of the livestock rather than to increase the feed intake so that the livestock can feed themselves enough. It is effective.

Therefore, the present invention is invented to solve the problems of the conventional feed intake enhancer as described above, feed intake in order to increase the feed intake of livestock feed is significantly reduced due to diseases or stress, feed intake to improve productivity It is an object of the present invention to provide a growth and growth promoter composition and a method of preparing the same.

In order to achieve the above object, the present invention is 0.2 ~ 5.0% by weight of the hawthorn extract, 2.0 ~ 20.0% by weight of ciproheptadine dispersion, 1.0 ~ 5.0% by weight of liquid paraffin, 25.0 ~ 50.0% by weight zeolite, and roasted rice husk powder It is characterized by being formed by mixing 25.0 ~ 71.8% by weight.

In addition, the present invention comprises the first step of preparing a hawthorn extract by putting the dried hawthorn powder in 70% ethanol solution and adding ganbanite to extract at room temperature for 3 to 7 days and then concentrated under reduced pressure the filtered solution; Dissolving ciproheptadine with a mixture of ethanol, polyethylene glycol, and polysorbate 80 to adsorb to silicon dioxide to prepare a ciproheptadine dispersion; 0.2 to 5.0% by weight of hawthorn extract, 2.0 to 20.0% by weight of ciproheptadine dispersion, 1.0 to 5.0% by weight of liquid paraffin, 25.0 to 50.0% by weight of zeolite, and 25.0 to 71.8% by weight of roasted rice husk powder were added to the mixer. After the third step of forming a composition by mixing; characterized by including.

As described above, by providing the feed intake promotion and growth promoter composition of the present invention and a method for manufacturing the same, the feed intake can be effectively restored or enhanced by adding to the feed to the animals whose appetite is deteriorated due to disease or stress. It has the effect of promoting livestock growth and improving productivity.

1 is a block diagram showing a manufacturing process of the composition according to the present invention.

Explanation of Major Symbols in Drawings

S100 ~ S300: 1st step ~ 3rd step

The present invention is 0.2 to 5.0% by weight of the hawthorn extract, ciproheptadine dispersion 2.0 to 20.0% by weight, liquid paraffin 1.0 to 5.0% by weight, zeolite 25.0 to 50.0% by weight, and roasted rice husk powder 25.0 to 71.8% by weight It is characterized by being formed.

Hereinafter, with reference to the accompanying drawings will be described in detail the present invention.

Feed intake enhancement and growth promoting agent according to the present invention includes the acid extract and ciproheptadine as an active ingredient, in particular composed of a composite composition composed of acid extract, ciproheptadine, zeolite, liquid paraffin and roasted chaff powder In addition, it is possible to solve the problem of existing products that the feed intake improvement effect is insufficient by adding to the feed at a specific time such as high temperature during the summer when the feed intake decreases or when a disease occurs or the reason, movement, and stress.

The hawthorn extract used as a main ingredient in the present invention extracts dried fruits of hawthorn (Crataegus pinnatifida bunge) with ethanol or water and concentrates the filtered solution under reduced pressure to promote the secretion of various digestive enzymes as a dry powder to help digestion and immunity. It has excellent reinforcing effect, strengthens anti-medical force, and is effective in preventing indigestion, enteritis, hepatitis, jaundice and high blood pressure in human body because of its excellent effect on inhibiting liver cancer and lowering blood pressure.

Cyproheptadine (Cyproheptadine), which is used as a main ingredient in the present invention, is a dibenzocycloheptene piperidine-based antihistamine. It is used for the treatment of gall bladder, vasomotor edema, and also for the treatment of anorexia and weight loss. The anti-histamine pharmacological mechanism of ciproheptadine is sporoheptadine binds to the histamine H1 receptor to exhibit an antihistamine effect, and the appetite promoting mechanism is that ciproheptadine competitively inhibits the action of serotonin.

That is, serotonin binds to the 5-HT2C serotonin receptor in the satiety center and feels satiety. Ciproheptadine binds to the satiety center instead of serotonin, thereby inhibiting the action of serotonin, making it less likely to continue eating. It helps to help.

Zeolite used as an excipient in the present invention is an aluminum silicate hydrate of alkali and alkaline earth metals, which does not cause physical and chemical reactions with active ingredients, has excellent preservation and low moisture content, and is used as an excipient of feed additives to maintain stability. .

Roasted rice husk powder used as an excipient in the present invention is a powder crushed to 50 to 100 mesh size after firing rice hull (Rice hull) is a preservative without causing a physical chemical reaction with the active ingredients and has a low moisture content feed additive It is used as an excipient of.

Liquid paraffin used as a stabilizer in the present invention is a mixture of hydrocarbons obtained from petroleum, colorless, odorless, tasteless to improve the blending and uniformity in the manufacture of feed additives without improving the active ingredient and to improve the stability of the product It is used as an additive for.

As the main component of the hawthorn extract used in the present invention, it is preferable to use 0.2 to 5.0% by weight based on the total weight of the composition.

When the acid extract is less than 0.2% by weight, feed intake enhancement and growth promoting effects are insufficient, and when it is 5.0% by weight or more, economical efficiency is lowered, which is not preferable.

Ciproheptadine, which is a main component of the feed intake enhancing and growth promoter composition, preferably contains 0.1 to 1.0 wt% based on the total weight of the composition.

When the ciproheptadine is less than 0.1% by weight, feed intake enhancement and growth promoting effects are insufficient, and when it is 1.0% by weight or more, it is not preferable to be applied to livestock which is an expensive animal compared to the effect.

Fluid paraffin, a stabilizer used in the present invention, is preferably used 1.0 to 5.0% by weight based on the total weight of the composition.

When the liquid paraffin is 1.0% by weight or less, it causes a problem in the stability of the composition, and when 5.0% by weight or more is not preferable due to the excessive use.

Zeolite as an excipient in the feed intake promotion and growth accelerator composition according to the present invention is preferably used 25.0 ~ 50.0% by weight based on the total weight of the composition.

When the zeolite is 25.0 wt% or less, it causes a problem in the stability of the composition (uniformity maintenance), and when it is 50.0 wt% or more, it also causes a problem in the stability of the composition, which is not preferable.

Baked chaff powder is an excipient used in the present invention is preferably used 25.0 ~ 71.8% by weight based on the weight of the total composition.

When the roasted rice husk powder is 25.0% by weight or less, it causes a problem in the stability (uniformity) of the composition, and when 71.8% by weight or more also causes a problem in the stability of the composition is not preferable.

Such a method for preparing feed intake promotion and growth promoter compositions according to the present invention is as follows.

The first step (S100) is a process for manufacturing the hawthorn extract, each 250g dried hawthorn in 1,000ml of 70% ethanol and put about 20g of ganban stone and left at room temperature for 3 to 7 days and then filtered through a 20 mesh sieve Then, concentrated under reduced pressure to prepare an hawthorn extract.

At this time, the extraction time in the first step (S100) hawthorn extract manufacturing step is preferably 3 to 7 days, if less than 3 days is not preferable because the extraction state is insufficient and more than 7 days no extraction occurs. .

The second step 200 is a process for preparing a ciproheptadine dispersion in order to improve the mixing, uniformity and bioavailability of ciproheptadine, 100ml of anhydrous ethanol and polyethyleneglycol-400 (Polyethyleneglycol-400) Add 100 g, start stirring at a speed of 120 rpm, add 11 g of ciproheptadine hydrochloride and stir for 60 minutes to completely dissolve. Then, add 10 g of polysorbate 80 (Polysorbate 80), lower the stirring speed to 30 rpm, and stir for 30 minutes. After preparing the ciproheptadine solution, put 99g of silicon dioxide in the powder mixer, run the mixer at 30 rpm, spray the ciproheptadine solution, and when the adsorbate is completed, dry it at 80 ℃ hot air dryer for 2 hours and then grind it with a grinder. This completes the ciproheptadine dispersion.

At this time, in the second step (S200) ciproheptadine dispersion manufacturing process it is preferable to use 30.0 to 60.0% by weight, based on the weight of the total ciproheptadine solution of the anhydrous ethanol and silver, when 30.0% by weight or less In the case of insufficient ciproheptadine dissolving effect and more than 60.0% by weight, the amount of polyethylene glycol 400 is relatively reduced, which is not preferable because of insufficient ciproheptadine dissolving effect.

In addition, in the second step (S200) ciproheptadine dispersion manufacturing process, the polyethylene glycol 400 is preferably used 25.0 to 62.5% by weight, based on the total weight of ciproheptadine solution, when 25.0% by weight or less In the case of insufficient ciproheptadine dissolution effect and more than 62.5% by weight, the amount of anhydrous ethanol is relatively decreased, so the ciproheptadine dissolution effect is insufficient, which is not preferable.

In the second step (S200) ciproheptadine dispersion manufacturing process, polysorbate 80 is preferably used 2.5 to 10.0% by weight based on the total weight of ciproheptadine solution, if 2.5% by weight or less If the stability of roheptadine is lower than 10% by weight, it is not preferable to use excessively.

The third step (S300) is a step of preparing the final composition, 0.2 ~ 5.0% by weight of the hawthorn extract prepared in the first step (S100) and the ciproheptadine dispersion prepared in step (S200) 2.0 ~ 20.0 After the weight%, zeolite 25.0 ~ 50.0% by weight and roasted rice husk powder 20.0 ~ 71.8% by weight, respectively, into the mixer and mixed with liquid paraffin 1.0 ~ 5.0% by weight while mixing for 10 to 30 minutes at 120rpm to form a composition .

The present invention can be understood in more detail by the following examples and experimental examples, the following examples are intended to illustrate the present invention only and not intended to limit the scope of the present invention.

Example 1

To prepare a feed intake enhancer and growth promoter composition from the components shown in Table 1.

Table 1

ingredient	1 kg
Hawthorn extract	5 g
Ciproheptadine Dispersion	100 g
Liquid paraffin	20 g
Zeolite	400 g
Grilled chaff powder	475 g

The process of preparing a feed intake enhancement and growth promoter composition is as follows. Sansa extract and ciproheptadine dispersion, zeolite and roasted rice husk powder in each order in the mixer, and then mixed by spraying liquid paraffin for 10 to 30 minutes at a speed of 120rpm to prepare a feed intake enhancement and growth promoter composition.

Example 2

To prepare a feed intake enhancement and growth promoter composition from the components of the following Table 2.

TABLE 2

ingredient	1 kg
Hawthorn extract	5 g
Liquid paraffin	20 g
Zeolite	400 g
Grilled chaff powder	475 g

The process of preparing a feed intake enhancement and growth promoter composition is as follows. The hawthorn extract, zeolite and roasted rice husk powder were put into the mixer in order, and then mixed with the liquid paraffin for 10 to 30 minutes at a speed of 120 rpm to prepare a feed ingestion and growth promoter composition.

Example 3

To prepare a feed intake enhancement and growth promoter composition from the components of the following Table 3.

TABLE 3

ingredient	1 kg
Ciproheptadine Dispersion	100 g
Liquid paraffin	20 g
Zeolite	400 g
Grilled chaff powder	475 g

The process of preparing a feed intake enhancement and growth promoter composition is as follows. The ciproheptadine dispersion, zeolite and roasted rice husk powder are put into a mixer in order, and then mixed at a speed of 120 rpm for 10 to 30 minutes while spraying liquid paraffin to prepare a feed ingestion and growth promoter composition.

Example 4

To prepare a feed intake enhancement and growth promoter composition from the components of Table 4.

Table 4

ingredient	1 kg
Hawthorn extract	5 g
Ciproheptadine Dispersion	100 g
Zeolite	400 g
Grilled chaff powder	475 g

The process of preparing a feed intake enhancement and growth promoter composition is as follows. Sansa extract, ciproheptadine dispersion, zeolite and roasted rice husk powder are put in a mixer in order, and then mixed for 10 to 30 minutes at a speed of 120 rpm to prepare a feed ingestion and growth promoter composition.

Example 5

To prepare a feed intake enhancement and growth promoter composition from the components of Table 5.

Table 5

ingredient	1 kg
Hawthorn extract	5 g
Ciproheptadine Dispersion	100 g
Liquid paraffin	20 g
Grilled chaff powder	475 g

The process of preparing a feed intake enhancement and growth promoter composition is as follows. Sansa extract, ciproheptadine dispersion, and roasted rice husk powder were put into the mixer in order, and then mixed with the liquid paraffin for 10 to 30 minutes at a speed of 120 rpm to prepare a feed ingestion and growth promoter composition.

Example 6

To prepare a feed intake enhancement and growth promoter composition from the components of the following Table 6.

Table 6

ingredient	1 kg
Hawthorn extract	5 g
Ciproheptadine Dispersion	100 g
Liquid paraffin	20 g
Zeolite	400 g

The process of preparing a feed intake enhancement and growth promoter composition is as follows. Sansa extract, ciproheptadine dispersion and zeolite were put into the mixer in order, respectively, and mixed with the liquid paraffin for 10 to 30 minutes at a speed of 120 rpm to prepare a feed ingestion and growth promoter composition.

TABLE 7

Composition of Feed Intake Enhancer Composition

Kinds	Feed Intake Enhancement and Growth Accelerator
Example 1	Hawthorn extract + ciproheptadine + liquid paraffin + zeolite + roasted rice husk powder
Example 2	Sansa Extract + Liquid Paraffin + Zeolite + Roasted Chaff Powder
Example 3	Ciproheptadine + Liquid Paraffin + Zeolite + Roasted Chaff Powder
Example 4	Hawthorn extract + ciproheptadine + zeolite + roasted rice husk powder
Example 5	Sansa extract + ciproheptadine + liquid paraffin + roasted rice husk powder
Example 6	Sansa Extract + Ciproheptadine + Liquid Paraffin + Zeolite

Experimental Example 1 Feed Intake Enhancement and Growth Promotion Effect Experiment

1. Experiment Method

680 pigs of 9-week-old piglets whose appetite was deteriorated due to long-distance travel were divided into 4 groups for each piglet, and Examples 1, 2, and 3 were added 0.1% to the blended feed for 5 weeks until 14 weeks of age. As a control, only compounded feed was given freely. Total feed intake, weight gain and feed rate were measured from the start of the test to the end of the test.

2. Experimental Results

Feed intake was the highest in the Example 1 feed group was increased by 15.1% compared to the control group, the Example 2 feed group was increased 4.5%, Example 3 feed group was increased by 7.9%, respectively. The weight gain was increased by 17.7% in Example 1, 5.1% in Example 2, and 8.6% in Example 3, respectively.

Feed intake, weight gain and feed rate of each example composition are shown in Table 8 below.

Table 8

Kinds	Daily average feed intake per soybean	Average weight gain per head per day	Feed rate
Control	1,586 g	708 g	2.24
Example 1	1,825 g	833 g	2.19
Example 2	1,658 g	744 g	2.23
Example 3	1,711 g	769 g	2.22

Experimental Example 2 Stability Experiment

1. Experiment Method

In order to determine the stability of each composition, 100 kg of each composition was produced, packed in 5 bags of 20 kg, and stored for 12 months at room temperature. Was measured.

2. Experimental Results

The compositions of Examples 1, 2, and 3 were in good condition of maintaining uniformity, and the contents of the active ingredients for each sample were very stable, but Examples 4, 5, and 6 were poor in uniformity. In addition, the active ingredient content is also significantly reduced compared to Examples 1, 2, 3 was poor in stability.

The uniformity maintenance state and the effective part content of each example composition are shown in Table 9 below.

Table 9

Kinds	Mixing condition	Sansa content	Ciproheptadine Content
Example 1	Good	99.8%	99.2%
Example 2	Good	99.5%	-
Example 3	Good	-	99.1%
Example 4	Bad	88.6%	94.6%
Example 5	Bad	87.9%	89.1%
Example 6	Bad	92.3%	97.2%

The present invention is 0.2 to 5.0% by weight of the hawthorn extract, ciproheptadine dispersion 2.0 to 20.0% by weight, liquid paraffin 1.0 to 5.0% by weight, zeolite 25.0 to 50.0% by weight, and roasted rice husk powder 25.0 to 71.8% by weight By providing the formed feed ingestion and growth promoter composition, by adding to the feed to feed animals that have decreased appetite due to disease or stress, the feed intake can be effectively restored or promoted to promote the growth of the animals and improve productivity. It is an invention that has the effect of making it possible to be a very useful invention and an invention of very high industrial applicability.

Claims

Sansa extract and ciproheptadine as an active ingredient,

0.2 to 5.0% by weight of the hawthorn extract, 2.0 to 20.0% by weight of ciproheptadine dispersion, 1.0 to 5.0% by weight of liquid paraffin, 25.0 to 50.0% by weight of zeolite, and 25.0 to 71.8% by weight of roasted rice husk powder Feed intake promoting and growth promoter composition, characterized in that.
A first step of preparing a hawthorn extract by putting dried hawthorn powder in 70% ethanol solution, adding elvan rock, extracting at room temperature for 3 to 7 days, and then concentrating the filtrate under reduced pressure;

Dissolving ciproheptadine with a mixture of ethanol, polyethylene glycol-400, and polysorbate 80 to adsorb to silicon dioxide to prepare a ciproheptadine dispersion;

0.2 to 5.0% by weight of hawthorn extract, 2.0 to 20.0% by weight of ciproheptadine dispersion, 1.0 to 5.0% by weight of liquid paraffin, 25.0 to 50.0% by weight of zeolite, and 25.0 to 71.8% by weight of roasted rice husk powder were added to the mixer. After mixing the third step of forming a composition; feed intake enhancement and growth promoter manufacturing method comprising the.
The method of claim 2,

The ciproheptadine dispersion,

Add 100 ml of anhydrous ethanol and 100 g of polyethylene glycol-400 to the stirring tank, start stirring at a speed of 120 rpm, add 11 g of ciproheptadine hydrochloride, stir for 60 minutes, dissolve completely, add 10 g of polysorbate 80, and then stir the speed of 30 rpm. After the mixture was stirred for 30 minutes to prepare a ciproheptadine solution, 99 g of silicon dioxide was added to the powder mixer, and the mixture was sprayed at 30 rpm while spraying the ciproheptadine solution. A method of preparing feed ingestion and growth promoter, characterized in that it is dried and then ground with a grinder.