CN116998603A - Efficient micromolecular organic acidulant and preparation method thereof - Google Patents
Efficient micromolecular organic acidulant and preparation method thereof Download PDFInfo
- Publication number
- CN116998603A CN116998603A CN202311028478.0A CN202311028478A CN116998603A CN 116998603 A CN116998603 A CN 116998603A CN 202311028478 A CN202311028478 A CN 202311028478A CN 116998603 A CN116998603 A CN 116998603A
- Authority
- CN
- China
- Prior art keywords
- acidulant
- acid
- chitosan
- organic acidulant
- adsorbent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 229920001661 Chitosan Polymers 0.000 claims abstract description 37
- 150000003384 small molecules Chemical class 0.000 claims abstract description 20
- 239000003463 adsorbent Substances 0.000 claims abstract description 19
- KSIOSIYBQLJZIW-UHFFFAOYSA-N 4-ethoxycarbonyloxy-3,5-dimethoxybenzoic acid Chemical compound CCOC(=O)OC1=C(OC)C=C(C(O)=O)C=C1OC KSIOSIYBQLJZIW-UHFFFAOYSA-N 0.000 claims abstract description 12
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical group O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 12
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 11
- 150000007524 organic acids Chemical class 0.000 claims abstract description 10
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 9
- 239000012043 crude product Substances 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 238000010438 heat treatment Methods 0.000 claims abstract description 5
- 230000003213 activating effect Effects 0.000 claims abstract description 4
- 238000004108 freeze drying Methods 0.000 claims abstract description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 15
- 229910052901 montmorillonite Inorganic materials 0.000 claims description 9
- 238000000498 ball milling Methods 0.000 claims description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 7
- 239000008103 glucose Substances 0.000 claims description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 235000011054 acetic acid Nutrition 0.000 claims description 5
- 238000005507 spraying Methods 0.000 claims description 5
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 3
- 235000019253 formic acid Nutrition 0.000 claims description 3
- 235000019260 propionic acid Nutrition 0.000 claims description 3
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 3
- -1 small molecule organic acid Chemical class 0.000 claims description 3
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 239000011230 binding agent Substances 0.000 claims description 2
- 235000015165 citric acid Nutrition 0.000 claims description 2
- 239000002270 dispersing agent Substances 0.000 claims description 2
- 239000001530 fumaric acid Substances 0.000 claims description 2
- 235000011087 fumaric acid Nutrition 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 238000005469 granulation Methods 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- 239000000047 product Substances 0.000 abstract description 9
- 244000144972 livestock Species 0.000 abstract description 8
- 244000144977 poultry Species 0.000 abstract description 8
- 238000011161 development Methods 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 230000002045 lasting effect Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000029087 digestion Effects 0.000 description 3
- 238000011056 performance test Methods 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid ester group Chemical group C(CCCCCCCCCCC)(=O)O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 235000019629 palatability Nutrition 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000011258 core-shell material Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 235000015816 nutrient absorption Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
Abstract
The invention relates to a high-efficiency small-molecule organic acidulant and a preparation method thereof, wherein the acidulant comprises the following components in parts by mass: 30-100 parts of small molecular organic acid, 15-35 parts of adsorbent, 10-20 parts of modified chitosan and 1-5 parts of auxiliary agent; wherein the modified chitosan is obtained by reacting 4-ethoxycarbonyloxy-3, 5-dimethoxy benzoic acid with chitosan; the adsorbent is hydroxylated montmorillonite. The preparation method of the modified chitosan comprises the following steps: s1, mixing chitosan, 4-ethoxycarbonyloxy-3, 5-dimethoxy benzoic acid and an activating agent, and heating and stirring to react to obtain a crude product; s2, dialyzing and freeze-drying the crude product to obtain the modified chitosan. The high-efficiency small-molecule organic acidulant has strong slow release performance, realizes lasting effect, is beneficial to the growth and development of livestock and poultry, and solves the problems existing in the existing products.
Description
Technical Field
The invention relates to the technical field of feeds, in particular to a high-efficiency small-molecule organic acidulant and a preparation method thereof.
Background
The acidulant is a widely applied feed additive, and the component plays an important role in improving the feeding condition of livestock and poultry.
The acidulant can reduce the pH value of the digestive system of livestock and poultry, acidify the gastrointestinal tract, promote digestion, improve nutrient absorption and conversion, can directly participate in-vivo energy metabolism, and has no residue, drug resistance and toxic or side effect. Meanwhile, the acidulant also has the effects of fresh feed, sterilization and mildew prevention, palatability improvement, secondary pollution reduction, maintenance of the nutritional value of the feed and prolongation of the storage time of the feed. The acidulant can also help young animals establish healthy flora balance (control harmful bacteria in the digestive tract), inhibit and neutralize digestive tract pathogenic bacteria, promote gastrointestinal development and immune response, promote healthy growth of intestinal villi, stimulate animal immune system and prevent disease from entering from the mouth. In addition, the acid preparation also has the function of astringing, can protect liver and heart vessels, reduce the formation of harmful metabolites, reduce the burden of toxin decomposition of the liver, improve the health condition of animals and exert the maximum potential.
However, the small molecular organic acid component is easy to lose in the processing, storage and use processes, is easy to react with alkaline substances in the feed, reduces the nutritive value in the feed, and cannot effectively ensure the stability and effect of the product; the rapid release of acidic substances causes the mutation of the pH value in animals, and can damage oral mucosa, affect the palatability of feed and affect the secretion of gastric acid and pepsin of animals. Therefore, the existing organic acidulant products still have more problems, and the demands of the market are difficult to meet.
In view of the foregoing, there is a need to develop a new technical solution to solve the problems in the prior art.
Disclosure of Invention
Based on the above, the invention provides a high-efficiency small-molecule organic acidulant and a preparation method thereof. The invention adopts the micromolecular organic acid and the adsorbent as the core structure, the modified chitosan as the shell structure, the compatibility among the components is good, the stability of the product is effectively improved, the product is easier to store, the high-efficiency micromolecular organic acidating agent has stronger slow release performance, the lasting effect is realized, the growth and development of livestock and poultry are facilitated, and the problems existing in the existing product are solved.
The invention aims to provide a high-efficiency small-molecule organic acidulant which comprises the following components in parts by weight:
wherein,
the modified chitosan is obtained by reacting 4-ethoxycarbonyloxy-3, 5-dimethoxy benzoic acid with chitosan;
the adsorbent is hydroxylated montmorillonite.
Further, the preparation method of the modified chitosan comprises the following steps:
s1, mixing chitosan, 4-ethoxycarbonyloxy-3, 5-dimethoxy benzoic acid and an activating agent, and heating and stirring to react to obtain a crude product;
s2, dialyzing and freeze-drying the crude product to obtain the modified chitosan.
Further, in the step S1, the temperature of the heating and stirring reaction is 30-50 ℃ and the time is 5-10h.
Further, the mass ratio of the chitosan to the 4-ethoxycarbonyloxy-3, 5-dimethoxy benzoic acid is 1 (0.5-5).
Further, the preparation method of the adsorbent comprises the following steps:
mixing montmorillonite powder with glucose, performing ball milling treatment, and purifying to obtain the adsorbent.
According to the invention, the montmorillonite and the glucose are mixed for ball milling treatment, so that the specific surface area of montmorillonite powder can be further increased, the appearance is improved, and the organic acid micromolecule is better adsorbed; in addition, in the ball milling process, glucose is tightly adhered to the surface of montmorillonite powder, so that the friction force among particles is increased, on the other hand, the energy in a ball milling tank is increased along with the increase of the ball milling time and the temperature, and part of hydroxyl groups on the surface of glucose molecules are fallen off and connected with unsaturated cations in montmorillonite, so that the montmorillonite has more surface hydroxyl groups, and the compatibility and the adsorption capacity of the adsorbent are further enhanced.
Further, the small molecule organic acid is selected from one or more of formic acid, propionic acid, acetic acid, citric acid and fumaric acid.
Further, the high-efficiency small-molecule organic acidulant comprises the following components in parts by weight:
further, the auxiliary agent is one or more selected from inorganic salts, dispersants, film forming agents, antioxidants, binders and preservatives.
The invention also provides a preparation method of the high-efficiency small-molecule organic acidulant, which comprises the following steps:
uniformly mixing small molecular organic acid, an adsorbent and an auxiliary agent, and adding the mixture into a granulator for granulation to obtain a nuclear structure; spraying modified chitosan on the surface of the core structure, and drying to obtain the high-efficiency micromolecular organic acidating agent.
The invention has the following beneficial effects:
1. the high-efficiency small-molecule organic acidulant provided by the invention adopts small-molecule organic acid such as formic acid, acetic acid and propionic acid as components, and has the effects of promoting digestion of livestock and poultry, inhibiting growth of pathogenic bacteria in stomach and intestine (crop), keeping health of livestock and poultry, reducing use of medicines and eliminating ammonia odor of livestock and poultry houses.
2. The efficient micromolecular organic acidulant has a core-shell structure, wherein the core structure comprises an adsorbent, and the adsorbent is prepared by mixing montmorillonite powder and glucose and performing ball milling treatment, has larger specific surface area and more active functional groups, so that more micromolecular organic acid can be adsorbed, and the stability is higher; the modified chitosan grafted with 4-ethoxycarbonyloxy-3, 5-dimethoxy benzoic acid has the advantages that a large number of phenoxy, alkoxy, ester groups and other structures are introduced into the modified chitosan, so that the polarity of the chitosan is improved, the acidulant product has more ideal slow-release function, and the acidulant effect can be permanently effective; in addition, hydrogen bonds are easily formed between various oxygen-containing functional groups in the core structure and the shell structure, so that a synergistic effect is generated, the stability of the product is further enhanced through intermolecular forces, and the shelf life is prolonged.
Detailed Description
In order to more clearly illustrate the technical solution of the present invention, the following examples are set forth. The starting materials, reactions and workup procedures used in the examples are those commonly practiced in the market and known to those skilled in the art unless otherwise indicated.
The words "preferred," "more preferred," and the like in the present disclosure refer to embodiments of the present disclosure that may provide certain benefits in some instances. However, other embodiments may be preferred under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.
It should be understood that, except in any operating examples, or where otherwise indicated, quantities or all numbers expressing, for example, quantities of ingredients used in the specification and claims are to be understood as being modified in all instances by the term "about". Accordingly, unless indicated to the contrary, the numerical parameters set forth in the following specification and attached claims are approximations that may vary depending upon the desired properties to be obtained by the present invention.
The chitosan in the examples of the present invention was purchased from Shandong Seiya chemical Co., ltd.
The auxiliary agent in the embodiment of the invention is sodium alginate.
In the embodiment of the invention, "parts" refer to parts by weight.
The preparation method of the modified chitosan in the embodiment of the invention comprises the following steps:
s1, dissolving chitosan in 2% acetic acid solution, then adding an absolute ethyl alcohol solution of 4-ethoxycarbonyloxy-3, 5-dimethoxy benzoic acid and an activating agent (the mass ratio of chitosan, 4-ethoxycarbonyloxy-3, 5-dimethoxy benzoic acid, EDC, HCl and NHS is 8:8:8.3:1, and the mass ratio of chitosan, acetic acid solution and absolute ethyl alcohol is 1:49:25), and stirring and reacting for 6 hours at 40 ℃ to obtain a crude product;
s2, performing distilled water dialysis and freeze drying on the crude product to obtain the modified chitosan.
The preparation method of the adsorbent in the embodiment of the invention comprises the following steps:
mixing montmorillonite powder and glucose with the mass ratio of 1:5, adding the mixture into a ball mill for ball milling treatment for 10 hours, wherein the ball material ratio is 5:1, the rotating speed is 400rpm, and filtering, washing and drying the mixture to obtain the adsorbent.
Example 1
The efficient micromolecular organic acidulant comprises the following components in parts by weight:
the preparation method of the high-efficiency small-molecule organic acidulant comprises the following steps:
uniformly mixing small molecular organic acid, adsorbent and auxiliary agent according to the parts by weight, and adding into a granulator for granulating to obtain a nuclear structure; spraying modified chitosan on the surface of the core structure, and drying to obtain the high-efficiency micromolecular organic acidating agent.
Example 2
The efficient micromolecular organic acidulant comprises the following components in parts by weight:
the preparation method of the high-efficiency small-molecule organic acidulant comprises the following steps:
uniformly mixing small molecular organic acid, adsorbent and auxiliary agent according to the parts by weight, and adding into a granulator for granulating to obtain a nuclear structure; spraying modified chitosan on the surface of the core structure, and drying to obtain the high-efficiency micromolecular organic acidating agent.
Example 3
The efficient micromolecular organic acidulant comprises the following components in parts by weight:
the preparation method of the high-efficiency small-molecule organic acidulant comprises the following steps:
uniformly mixing small molecular organic acid, adsorbent and auxiliary agent according to the parts by weight, and adding into a granulator for granulating to obtain a nuclear structure; spraying modified chitosan on the surface of the core structure, and drying to obtain the high-efficiency micromolecular organic acidating agent.
Comparative example 1
The difference between this comparative example and example 1 is that: the modified chitosan was replaced with unmodified chitosan, and other components and preparation methods were the same as in example 1.
Comparative example 2
The difference between this comparative example and example 1 is that: in the preparation method of the modified chitosan, 4-ethoxycarbonyloxy-3, 5-dimethoxybenzoic acid was replaced with lauric acid, and other components and preparation methods were the same as in example 1.
Test case
Performance tests were performed on the small molecule organic acidulant samples prepared in examples 1-3 and comparative examples 1-2.
The testing method comprises the following steps:
stability test:
the small molecule organic acidulant samples prepared in examples 1-3 and comparative examples 1-2 were left to stand for 3 months at 40 ℃ + -2 ℃ and 75% + -5% RH, and then the appearance of the samples was examined and evaluated.
Growth promoting performance test:
50 weaned pigs with similar batches, similar weight and good health condition are randomly divided into 5 groups of 10 pigs for test. The conventional commercial piglet feed is adopted as the feed, and 2kg/t of the small molecular organic acidulant prepared in the examples 1-3 or the comparative examples 1-2 is added into each group of feed, and after 30 days of feeding, the average weight of each group is measured.
The test results are shown in Table 1.
TABLE 1 Performance test results
According to the table 1, the high-efficiency small-molecule organic acidulant prepared by the embodiment of the invention has strong stability and good slow release property, can effectively improve the digestion and absorption levels of livestock and poultry, improves the gastrointestinal tract environment, and realizes a good weight increasing effect; and the comparative examples 1-2 with the modified chitosan can reduce the compatibility and stability of the acidulant product, and the slow release effect is not ideal enough, so that the effect is difficult to take effect for a long time, and the weight gain effect of piglets is poor. In conclusion, the invention has good application prospect.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.
Claims (9)
1. The efficient small-molecule organic acidulant is characterized by comprising the following components in parts by weight:
wherein,
the modified chitosan is obtained by reacting 4-ethoxycarbonyloxy-3, 5-dimethoxy benzoic acid with chitosan;
the adsorbent is hydroxylated montmorillonite.
2. The efficient small molecular organic acidulant of claim 1, wherein the preparation method of the modified chitosan comprises the following steps:
s1, mixing chitosan, 4-ethoxycarbonyloxy-3, 5-dimethoxy benzoic acid and an activating agent, and heating and stirring to react to obtain a crude product;
s2, dialyzing and freeze-drying the crude product to obtain the modified chitosan.
3. The efficient small molecular organic acidulant of claim 2, wherein in step S1, the temperature of the heating and stirring reaction is 30-50 ℃ for 5-10h.
4. The efficient micromolecular organic acidulant as claimed in claim 2, wherein the mass ratio of the chitosan and the 4-ethoxycarbonyloxy-3, 5-dimethoxy benzoic acid is 1 (0.5-5).
5. The efficient small molecule organic acidulant of claim 1, wherein the preparation method of the adsorbent comprises the following steps:
mixing montmorillonite powder with glucose, performing ball milling treatment, and purifying to obtain the adsorbent.
6. The efficient small molecule organic acidulant of claim 1, wherein the small molecule organic acid is selected from one or more of formic acid, propionic acid, acetic acid, citric acid, fumaric acid.
7. The efficient small-molecule organic acidulant of claim 6, wherein the efficient small-molecule organic acidulant comprises the following components in parts by weight:
8. the efficient small molecule organic acidulant of claim 1, wherein the auxiliary agent is selected from one or more of inorganic salts, dispersants, film formers, antioxidants, binders, preservatives.
9. The method for preparing the efficient small molecular organic acidulant as claimed in any one of claims 1 to 8, which comprises the following steps:
uniformly mixing small molecular organic acid, an adsorbent and an auxiliary agent, and adding the mixture into a granulator for granulation to obtain a nuclear structure; spraying modified chitosan on the surface of the core structure, and drying to obtain the high-efficiency micromolecular organic acidating agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311028478.0A CN116998603A (en) | 2023-08-16 | 2023-08-16 | Efficient micromolecular organic acidulant and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311028478.0A CN116998603A (en) | 2023-08-16 | 2023-08-16 | Efficient micromolecular organic acidulant and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116998603A true CN116998603A (en) | 2023-11-07 |
Family
ID=88565348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311028478.0A Pending CN116998603A (en) | 2023-08-16 | 2023-08-16 | Efficient micromolecular organic acidulant and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116998603A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109393205A (en) * | 2018-11-20 | 2019-03-01 | 界首市芙乐园农业发展有限公司 | A kind of preparation method of the fodder acidulant for aquaculture |
-
2023
- 2023-08-16 CN CN202311028478.0A patent/CN116998603A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109393205A (en) * | 2018-11-20 | 2019-03-01 | 界首市芙乐园农业发展有限公司 | A kind of preparation method of the fodder acidulant for aquaculture |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102578387B (en) | A kind of slowly-releasing compound acidulant for animal and fowl fodder and preparation method thereof and feed | |
| CN101120758B (en) | Liquid acidifier and preparation method | |
| JP6685407B2 (en) | Compositions for improving nitrogen utilization in ruminants | |
| CN109673847B (en) | Preparation process of intestinal slow-release acidifier | |
| CN107259141A (en) | The feed addictive and its making application method of a kind of in-pig | |
| CN110892947A (en) | Compound acidifier for poultry and preparation method and application thereof | |
| CN106922997A (en) | A kind of pig feed additive of efficient gastrointestinal mucosa repair function | |
| CN112244163A (en) | Antibiotic-free piglet feed additive and preparation method and application method thereof | |
| CN1947699A (en) | Method for producing water soluble fluorophenylnico | |
| CN105327334A (en) | Enteric coating pellets for treating piglet diarrhea and preparation method and application thereof | |
| WO2019080155A1 (en) | Conjugate acid salt of n,n-dimethylglycine and organic acid, and composition and application thereof | |
| CN112262926B (en) | Zinc oxide enteric sustained-release pellet, preparation method thereof and feed composition containing zinc oxide enteric-release pellet | |
| CN116998603A (en) | Efficient micromolecular organic acidulant and preparation method thereof | |
| CN114304413B (en) | Composite containing acidifying agent and preparation method thereof | |
| WO1991012731A1 (en) | Feed additive for ruminant | |
| CN112741218A (en) | Coated small-molecule organic acid composition and preparation method and application thereof | |
| CN113331306A (en) | Additive for improving livestock and poultry physiological function based on yucca, and preparation method and application thereof | |
| CN109527216A (en) | A kind of feed addictive of substitute antibiotics and the preparation method and application thereof | |
| CN114947000B (en) | Antibacterial growth-promoting composite additive for feed and preparation method and application thereof | |
| RU2674626C1 (en) | Method of obtaining composite supplement for correction of feed and food ration | |
| JP2008019236A (en) | Feed additive | |
| JP6687742B2 (en) | Formula of butyrate or its derivative and compound of benzoic acid, its production method and its use as feed additive | |
| CN110720559A (en) | Feed additive for improving piglet diarrhea | |
| CN117617390A (en) | Compound oral liquid for treating diarrhea of piglets, and preparation method and application thereof | |
| CN113100346A (en) | Pig feed capable of improving immunity and promoting growth and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |