CN1947699A - Method for producing water soluble fluorophenylnico - Google Patents
Method for producing water soluble fluorophenylnico Download PDFInfo
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- CN1947699A CN1947699A CN 200610069970 CN200610069970A CN1947699A CN 1947699 A CN1947699 A CN 1947699A CN 200610069970 CN200610069970 CN 200610069970 CN 200610069970 A CN200610069970 A CN 200610069970A CN 1947699 A CN1947699 A CN 1947699A
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- florfenicol
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- pure powder
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Abstract
A water-soluble florfenicol with high solubility (10000 PPM) and low cost is prepared from florfenicol powder and glucose powder through proportional mixing and stirring.
Description
Technical field
The present invention relates to the production method of veterinary drug, the water miscible production method of antibiotic florfenicol for animals particularly of new generation.
Background technology
Florfenicol claims Florfenicol, Sch-25298 again.Be spirit-Schering-Plough of U.S. elder generation the end of the seventies be to seek the new product developed in the better chloromycetin derivant, successively go on the market in a plurality of countries in Europe such as Japan, Korea S, Norway, France.Florfenicol is a chloromycetin veterinary special broad-spectrum antibiotic of new generation, have the characteristics such as wide, safe and efficient that distribute in the has a broad antifungal spectrum, good absorbing, body, remarkable for the poultry bacterial disease therapeutic effect due to the sensitive organism, gram positive bacteria and negative bacterium are all had effect, are the drug of first choices of the various infection that cause of Bacillus typhi, Salmonella paratyphi, Salmonella.Because chloromycetin has the untoward reaction of serious induced aplastic anemia, has forbidden being used for food animal, therefore, on animal diseases control, food animal especially, florfenicol has broad application prospects.But the former powder of florfenicol is a kind of water insoluble and can only be dissolved in the partly medicine of organic solvent, so its dosing way is very limited, develops water-solubility florfenicol and has the very strong market advantage.
Summary of the invention
The objective of the invention is to find out that a kind of technology is simple, cost is lower and the production method of the production water-solubility florfenicol that product quality is good.
The production method that this simplified method is produced high-quality water-solubility florfenicol promptly is to make mixing by a certain percentage after pure powder of florfenicol and the pure powder oven dry of glucose.
Thisly can be processed into various concentration according to actual needs with the mixed water-solubility florfenicol of glucose by a certain percentage, add a certain amount of water and then make the drinking agent of various concentration, injection, also available mixed powder is admixed in the feedstuff, be used for the treatment of poultry and aquatic animal because of bacterial each site infection of whole body, as the bacillary respiratory system disease of pig, horse etc., meningitis, pleuritis, intestinal infection and postpartum syndrome etc.The respiratory system of birds, intestinal infection, the infection that the pasteurellosis bacillus of Fish, golden Portugal bacterium and other gram negative bacteria cause.This water solublity medicinal liquid quality is good, no flocky precipitate.The florfenicol dissolubility that this method is produced can be brought up to 10000PPM.Because adjuvant is few, technology is simple, need are few with equipment, and this water-solubility florfenicol production cost water-solubility florfenicol commercially available medicine production cost more in the market can reduce by 20%.Drug effect then is higher than the latter.
The specific embodiment
The present invention will be further described to list a youngster embodiment below.
As to produce 100 kilograms of concentration be 10% water-solubility florfenicol powder, makes after available 10 kilograms of pure powder of florfenicol and 90 kilograms of pure powder oven dry of glucose mix.
As produce 100 kilograms of compound recipe water-solubility florfenicol powder, and wherein florfenicol contains 10%, and doxycycline contains 10%.Available 10 kilograms of pure powder of florfenicol and 80 kilograms of pure powder oven dry of glucose mix makes the water-solubility florfenicol powder, adds and makes after 10 kilograms of pure powder of doxycycline mix.
As produce 100 kilograms of compound recipe water-solubility florfenicol powder, and wherein florfenicol contains 10%, and neomycin contains 20%.Available 10 kilograms of pure powder of florfenicol and 70 kilograms of pure powder oven dry of glucose mix makes the water-solubility florfenicol powder, adds and makes after 20 kilograms of pure powder of neomycin mix.
Claims (3)
1. the production method of water-solubility florfenicol is made after it is characterized in that the pure powder of florfenicol and the pure powder of glucose mixed by a certain percentage.
2. the production method of water-solubility florfenicol as claimed in claim 1 is characterized in that wherein.Only just can produce water-solubility florfenicol fully as the solubilizing agent of florfenicol with the pure powder of glucose.
3. the production method of water-solubility florfenicol as claimed in claim 1 is produced water-solubility florfenicol and is added other medicine for the basis, does the compound recipe water-solubility florfenicol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610069970 CN1947699A (en) | 2006-11-04 | 2006-11-04 | Method for producing water soluble fluorophenylnico |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610069970 CN1947699A (en) | 2006-11-04 | 2006-11-04 | Method for producing water soluble fluorophenylnico |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1947699A true CN1947699A (en) | 2007-04-18 |
Family
ID=38017389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610069970 Pending CN1947699A (en) | 2006-11-04 | 2006-11-04 | Method for producing water soluble fluorophenylnico |
Country Status (1)
| Country | Link |
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| CN (1) | CN1947699A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009061780A1 (en) * | 2007-11-09 | 2009-05-14 | Schering-Plough Limited | Fast release solid formulation, preparation and use thereof |
| CN101843586A (en) * | 2010-04-29 | 2010-09-29 | 山东迅达康兽药有限公司 | Water-soluble micro powder containing florfenicol and preparation method thereof |
| CN102068443A (en) * | 2011-01-11 | 2011-05-25 | 清远海贝生物技术有限公司 | Compound florfenicol preparation for aquatic products and preparation method and application thereof |
| CN102743400A (en) * | 2012-07-19 | 2012-10-24 | 河北农业大学 | Pharmaceutical composition for preventing and treating turbot white feces disease |
| CN104173374A (en) * | 2014-07-25 | 2014-12-03 | 邳州正康生物技术有限公司 | Formula and preparation method of florfenicol powder |
| CN107233315A (en) * | 2017-05-10 | 2017-10-10 | 刘淑鹤 | Florfenicol soluble powder, Florfenicol liquid and preparation method thereof |
| CN109498580A (en) * | 2018-12-13 | 2019-03-22 | 广东温氏大华农生物科技有限公司 | A kind of Florfenicol granular preparation and its preparation process |
-
2006
- 2006-11-04 CN CN 200610069970 patent/CN1947699A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009061780A1 (en) * | 2007-11-09 | 2009-05-14 | Schering-Plough Limited | Fast release solid formulation, preparation and use thereof |
| JP2011503083A (en) * | 2007-11-09 | 2011-01-27 | インターベット インターナショナル ベー． フェー． | Rapid release liquid formulations, preparations and uses thereof |
| US7968599B2 (en) | 2007-11-09 | 2011-06-28 | Intervet International B.V. | Fast release solid formulation, preparation and use thereof |
| CN101843586A (en) * | 2010-04-29 | 2010-09-29 | 山东迅达康兽药有限公司 | Water-soluble micro powder containing florfenicol and preparation method thereof |
| CN101843586B (en) * | 2010-04-29 | 2012-05-23 | 山东迅达康兽药有限公司 | Water-soluble micro powder containing florfenicol and preparation method thereof |
| CN102068443A (en) * | 2011-01-11 | 2011-05-25 | 清远海贝生物技术有限公司 | Compound florfenicol preparation for aquatic products and preparation method and application thereof |
| CN102068443B (en) * | 2011-01-11 | 2012-06-27 | 清远海贝生物技术有限公司 | Compound florfenicol preparation for aquatic products and preparation method and application thereof |
| CN102743400A (en) * | 2012-07-19 | 2012-10-24 | 河北农业大学 | Pharmaceutical composition for preventing and treating turbot white feces disease |
| CN102743400B (en) * | 2012-07-19 | 2013-05-22 | 河北农业大学 | Pharmaceutical composition for preventing and treating turbot white feces disease |
| CN104173374A (en) * | 2014-07-25 | 2014-12-03 | 邳州正康生物技术有限公司 | Formula and preparation method of florfenicol powder |
| CN107233315A (en) * | 2017-05-10 | 2017-10-10 | 刘淑鹤 | Florfenicol soluble powder, Florfenicol liquid and preparation method thereof |
| CN109498580A (en) * | 2018-12-13 | 2019-03-22 | 广东温氏大华农生物科技有限公司 | A kind of Florfenicol granular preparation and its preparation process |
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Legal Events
| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20070418 |