CN117617390A - Compound oral liquid for treating diarrhea of piglets, and preparation method and application thereof - Google Patents
Compound oral liquid for treating diarrhea of piglets, and preparation method and application thereof Download PDFInfo
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- CN117617390A CN117617390A CN202311616925.4A CN202311616925A CN117617390A CN 117617390 A CN117617390 A CN 117617390A CN 202311616925 A CN202311616925 A CN 202311616925A CN 117617390 A CN117617390 A CN 117617390A
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- 206010012735 Diarrhoea Diseases 0.000 title claims abstract description 43
- 239000007788 liquid Substances 0.000 title claims abstract description 35
- 150000001875 compounds Chemical class 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title description 7
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 28
- 241000194032 Enterococcus faecalis Species 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 14
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229940046009 vitamin E Drugs 0.000 claims abstract description 14
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 14
- 239000011709 vitamin E Substances 0.000 claims abstract description 14
- 241000186660 Lactobacillus Species 0.000 claims abstract description 13
- 229940039696 lactobacillus Drugs 0.000 claims abstract description 13
- RIEABXYBQSLTFR-UHFFFAOYSA-N monobutyrin Chemical compound CCCC(=O)OCC(O)CO RIEABXYBQSLTFR-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 10
- 239000004094 surface-active agent Substances 0.000 claims abstract description 10
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims abstract description 9
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims abstract description 9
- 230000003405 preventing effect Effects 0.000 claims abstract description 7
- UHUSDOQQWJGJQS-UHFFFAOYSA-N glycerol 1,2-dioctadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCCCCCCCC UHUSDOQQWJGJQS-UHFFFAOYSA-N 0.000 claims abstract description 5
- IZHVBANLECCAGF-UHFFFAOYSA-N 2-hydroxy-3-(octadecanoyloxy)propyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCCCCCCCCCCC IZHVBANLECCAGF-UHFFFAOYSA-N 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 7
- 229940074045 glyceryl distearate Drugs 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 5
- 238000004090 dissolution Methods 0.000 claims description 5
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 5
- 229920000053 polysorbate 80 Polymers 0.000 claims description 5
- 238000000265 homogenisation Methods 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 4
- 206010059866 Drug resistance Diseases 0.000 abstract description 2
- 230000035622 drinking Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 22
- 241000282887 Suidae Species 0.000 description 11
- 239000002131 composite material Substances 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- 239000003124 biologic agent Substances 0.000 description 5
- 239000003651 drinking water Substances 0.000 description 5
- 235000020188 drinking water Nutrition 0.000 description 5
- 210000003608 fece Anatomy 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000009395 breeding Methods 0.000 description 4
- 230000001488 breeding effect Effects 0.000 description 4
- 230000002550 fecal effect Effects 0.000 description 4
- 235000021050 feed intake Nutrition 0.000 description 4
- 210000004347 intestinal mucosa Anatomy 0.000 description 4
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- 235000014655 lactic acid Nutrition 0.000 description 3
- 239000004310 lactic acid Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- UYXTWWCETRIEDR-UHFFFAOYSA-N Tributyrin Chemical compound CCCC(=O)OCC(OC(=O)CCC)COC(=O)CCC UYXTWWCETRIEDR-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
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- 238000000855 fermentation Methods 0.000 description 2
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- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 230000036541 health Effects 0.000 description 2
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- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 208000026775 severe diarrhea Diseases 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 108010062877 Bacteriocins Proteins 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
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- 150000001408 amides Chemical class 0.000 description 1
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- 238000009423 ventilation Methods 0.000 description 1
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- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
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- 238000003911 water pollution Methods 0.000 description 1
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Abstract
The invention provides a compound oral liquid for diarrhea of piglets, which is prepared by mixing the following components in parts by weight: 10-20 parts of natural vitamin E, 50-80 parts of glycerol butyrate, 50-100 parts of lactobacillus, 30-50 parts of streptococcus faecalis, 5-20 parts of glycerol distearate, 18-35 parts of caprylic/capric triglyceride, 8-15 parts of surfactant and 800-1200 parts of water. The compound oral liquid is added into piglet water for drinking, so that good effects of improving growth conditions and preventing diarrhea can be achieved, and economic loss in cultivation is reduced; in addition, the product prepared by the invention is green, safe and harmless, is not easy to generate drug resistance and is environment-friendly.
Description
Technical Field
The invention belongs to the technical field of prevention and treatment of diarrhea of piglets, and particularly relates to a compound oral liquid for diarrhea of piglets, and a preparation method and application thereof.
Background
The piglet has no good digestion capability and stress resistance, so that weaning stress is particularly easy to occur during weaning, and the weaning stress directly stimulates the intestinal tracts of the piglet, so that the health of the piglet is adversely affected, diarrhea and other problems occur, and great loss is caused to production. At present, diarrhea of piglets is a difficult problem in pig raising production, and in the production practice, diarrhea of piglets is mostly prevented by adding high-dose zinc oxide into feed. Although the biological agent has a certain preventive effect, the biological agent has low bioavailability, less than 10 percent of the biological agent can be utilized by organisms, and the rest of the biological agent is discharged through the ways of feces and urine, so that serious pollution is caused to the environment, and the biological agent has the original purpose of sustainable and healthy development of the aquaculture. Therefore, the composite functional bacteria additive is paid attention as a green, safe and harmless prevention and treatment measure.
Chinese patent CN113616715B discloses a fermented Chinese medicinal oral liquid for treating diarrhea of piglets and improving intestinal flora of piglets, which is prepared by taking various Chinese medicaments as raw materials and adopting various probiotics for fermentation. The whole preparation process involves fermentation, and is long in time consumption and low in production efficiency, and meanwhile, the difficulty in obtaining raw materials is increased due to the fact that traditional Chinese medicine materials are numerous.
Disclosure of Invention
Aiming at the defects existing in the prior art, the invention provides the compound oral liquid which can promote the growth of piglets, reduce diarrhea of piglets and meet the original purpose of sustainable and healthy development of the breeding industry.
In order to achieve the above purpose, the invention adopts the following technical scheme:
a compound oral liquid for treating diarrhea of piglets is prepared by mixing the following components in parts by weight: 10-20 parts of natural vitamin E, 50-80 parts of glycerol butyrate, 50-100 parts of lactobacillus, 30-50 parts of streptococcus faecalis, 5-20 parts of glycerol distearate, 18-35 parts of caprylic/capric triglyceride, 8-15 parts of surfactant and 800-1200 parts of water.
In some specific embodiments, the composition is preferably prepared by mixing the following components in parts by weight: 15 parts of natural vitamin E, 62 parts of glycerol butyrate, 70 parts of lactobacillus, 35 parts of streptococcus faecalis, 15 parts of glycerol distearate, 25 parts of caprylic/capric triglyceride, 10 parts of surfactant and 1000 parts of water.
Further, the effective viable count of the lactobacillus is 10 8 ～10 9 cfu/g; the effective viable count of the streptococcus faecalis is 10 8 ～10 9 cfu/g。
Further, the surfactant is any one of Tween 80 and glycerol.
The preparation method of the composite oral liquid comprises the following steps:
heating and dissolving the glyceryl distearate, cooling to normal temperature, sequentially adding natural vitamin E, glyceryl butyrate, caprylic/capric acid glyceride, lactobacillus, streptococcus faecalis and surfactant, mixing uniformly, adding water with a prescription amount, stirring, and homogenizing under high pressure to obtain the compound oral liquid.
Further, the heating and dissolving temperature is 40-50 ℃.
Further, the high-pressure homogenization specific conditions are as follows: pressure of 0.1-0.15 MPa, temperature of 120-130 ℃ and flow rate of 18-22 m 3 /h。
When the compound oral liquid is applied to preventing diarrhea of piglets, the compound oral liquid is prepared by the following components in volume ratio of 1: (800-1500) is added into water for piglets to drink.
Compared with the prior art, the invention has the beneficial effects that:
(1) The invention has the advantages of easily obtained raw materials, simple preparation process, high efficiency, convenient and fast preparation and oral administration, and has the effects of improving growth conditions, preventing diarrhea, simultaneously preventing drug resistance, and being green, safe, harmless and environment-friendly.
(2) The compound oral liquid prepared by the invention can increase the average weight of weaned pigs by 1.84kg within 0-28 days, and improve the feed conversion rate; the conventional diarrhea rate of piglets is reduced from 14.88% to 6.55%, the control effect is obvious, and the breeding benefit can be greatly improved.
Detailed Description
The present invention will be described in further detail with reference to specific examples so as to more clearly understand the present invention by those skilled in the art.
The invention provides a compound oral liquid for diarrhea of piglets, which comprises the following specific operations:
according to mass fraction, 5-20 parts of glyceryl distearate is heated to 40-50 ℃ for dissolution, cooled to normal temperature, 10-20 parts of natural vitamin E, 50-80 parts of glyceryl butyrate, 50-100 parts of lactobacillus, 30-50 parts of streptococcus faecalis, 18-35 parts of caprylic/capric triglyceride and 8-15 parts of surfactant are sequentially added and uniformly mixed, 800-1200 parts of water is added, and stirring is carried out, wherein the pressure is 0.1-0.15 MPa, the temperature is 120-130 ℃ and the flow is 18-22 m 3 Homogenizing under high pressure under the condition of/h to obtain the composite oral liquid.
The natural vitamin E in the formula is typical fat-soluble vitamin, the compound enriched in the vitamin E can play a role in maintaining normal physiological functions of animals, and the vitamin E has the functions of resisting oxidation, improving body immunity, improving animal meat quality and the like, and can be used as a feed additive in pig breeding. The butyrin is glyceride formed by esterifying one molecule of glycerol and three molecules of butyric acid, and the butyrin is used as a feeding intestinal mucosa nutrition active fat and has the function of mainly supplying energy to the intestinal mucosa; meanwhile, the glycerol butyrate can rapidly supplement nutrition of intestinal mucosa, repair the damage of the intestinal mucosa caused by various stresses, further improve the health of intestinal tracts, control diarrhea and improve the production performance. Lactic acid bacteria can ferment glucose (or utilize carbohydrate) to produce a large amount of lactic acid, and are an important strain for normal intestinal flora, and have the functions of regulating intestinal flora, preventing and relieving gastrointestinal diseases and enhancing immunity. The streptococcus faecalis can decompose part of protein to generate amide and amino acid, and can convert most of nitrogen-free extract of carbohydrate into lactic acid to promote the feed fiber to soften, thereby improving the feed conversion rate; the streptococcus faecalis can also produce a class of peptides or proteins called bacteriocins, and has certain antibacterial and antibacterial effects; the streptococcus faecalis is added into the feed, so that the organic matter discharge in the cultivation can be reduced, and the water pollution can be effectively reduced.
Example 1
The embodiment provides a compound oral liquid for treating diarrhea of piglets, which comprises the following specific operations:
heating 15 parts of glyceryl distearate to 45 ℃ for dissolution according to mass fraction, cooling to normal temperature, sequentially adding 15 parts of natural vitamin E, 62 parts of glyceryl butyrate, 70 parts of lactobacillus, 35 parts of streptococcus faecalis, 25 parts of caprylic/capric triglyceride and 10 parts of tween 80, uniformly mixing, adding 1000 parts of water, stirring, and homogenizing under high pressure under the conditions of 0.15MPa, 120 ℃ and 20L/min flow to obtain the composite oral liquid.
Example 2
The embodiment provides a compound oral liquid for treating diarrhea of piglets, which comprises the following specific operations:
heating 20 parts of glyceryl distearate to 45 ℃ for dissolution according to mass fraction, cooling to normal temperature, sequentially adding 20 parts of natural vitamin E, 70 parts of glyceryl butyrate, 80 parts of lactobacillus, 45 parts of streptococcus faecalis, 30 parts of caprylic/capric triglyceride and 15 parts of tween 80, uniformly mixing, adding 1000 parts of water, stirring, and homogenizing under high pressure under the conditions of 0.1MPa, 130 ℃ and 22L/min flow to obtain the composite oral liquid.
Example 3
The embodiment provides a compound oral liquid for treating diarrhea of piglets, which comprises the following specific operations:
heating 6 parts of glyceryl distearate to 45 ℃ for dissolution according to mass fraction, cooling to normal temperature, sequentially adding 10 parts of natural vitamin E, 50 parts of glyceryl butyrate, 50 parts of lactobacillus, 30 parts of streptococcus faecalis, 20 parts of caprylic/capric triglyceride and 10 parts of tween 80, uniformly mixing, adding 1000 parts of water, stirring, and homogenizing under high pressure under the conditions of 0.15MPa, 130 ℃ and 18L/min flow to obtain the composite oral liquid.
Effect verification
Further, in order to verify the diarrhea preventing effect of the compound oral liquid prepared in the above examples and comparative examples on piglets, a test was also performed, and the test method is as follows:
1. test animal and test design
Three-way piglets with average initial weight (6.77+/-1.30) kg after weaning for 12 days and 28 days are selected, and are divided into 2 groups according to the principle of initial weight balance, wherein each group comprises 6 replicates, and each replicate comprises 1 pig, and the specific grouping is as follows:
control group: and (5) drinking water normally.
Test group: according to the volume ratio of 1:1000 the compound oral liquid prepared in example 1 was added to drinking water.
2. Feeding management
The pig house was thoroughly cleaned and sterilized prior to the test and was left open 7d. During the test, the pig house is managed in a totally enclosed mode, and the sanitation, ventilation and drying of the pig house are kept. The temperature is controlled between 25 ℃ and 27 ℃. The control group and the test group are fed in separate columns, and individual identification is carried out through the ear tag, so that people can eat and drink water freely. Piglets were observed daily at regular intervals and data concerning their diarrhea were recorded for a total of 28d.
3. Measurement index and method
3.1 growth Properties
Each pig was weighed on a empty stomach of 0d, 7d, 14d, 21d and 28d, daily feed intake was recorded, and Average Daily Gain (ADG), average Daily Feed Intake (ADFI) and Feed Conversion Rate (FCR) were calculated for the control group and the test group, respectively, 0 to 14d, 15 to 28d, 0 to 28d, and the results are shown in table 1.
3.2 diarrhea index
The test shows the diarrhea condition of the piglets through three indexes of fecal index, diarrhea rate and diarrhea index. Fecal index: 0 minutes-normal feces (solids), 1 minute-wet feces (semi-solids), 3 minutes-thin feces (mild diarrhea), 5 minutes-watery feces (severe diarrhea). Among them, both the mild diarrhea and the severe diarrhea were regarded as diarrhea, and the results are shown in table 2.
The diarrhea rate and diarrhea index were calculated as follows: diarrhea rate: days of diarrhea/total test days. Diarrhea index: total fecal index/total number of days tested.
Table 1 piglet growth performance index conditions of each test group
As can be seen from table 1 above: the average weight gain of weaned piglets in test group 1 was 1.84kg compared to the control group at the end of the test period. Specifically: at 0d, the minimum weight of weaned pigs in the test group 1 is smaller than the minimum weight of weaned pigs in the control group, at 14d, the minimum weight of weaned pigs in the test group is close to that in the control group, and at 21d, the minimum weight of weaned pigs in the test group exceeds that in the control group. The result shows that after the oral liquid is added into the drinking water, the growth performance of the weaned piglets is improved, and the weight is increased more rapidly; compared with the control group, the weaned pigs in the test group have increased feed intake (P > 0.05) and reduced FCR (P > 0.05). The method shows that the oral liquid is added into the drinking water to improve the feed intake of weaned pigs and improve the FCR of weaned pigs.
Table 2 diarrhea index for piglets of each test group
As can be seen from table 2 above: compared with the control group, the weaned pigs in the test group 1 have significantly reduced fecal index, diarrhea rate and diarrhea index (P < 0.05) in the first two weeks, and have insignificant decrease in diarrhea related index (P > 0.05) in the second two weeks. However, from the whole test period results, the diarrhea-related index of weaned pigs in test group 1 was significantly reduced (P < 0.05) over the whole test period compared to the control group. The method shows that the related index of diarrhea can be effectively reduced by adding the oral liquid into drinking water.
From the above results, it can be seen that: the compound oral liquid prepared by the application has great positive effects on the growth condition and diarrhea condition of weaned pigs, perfectly meets the original purpose of sustainable and healthy development of the breeding industry, and is suitable for wide popularization and application.
Other materials or structures not specifically described in the present invention exist in the prior art and are commercially available.
The foregoing is merely a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. The compound oral liquid for treating diarrhea of piglets is characterized by being prepared by mixing the following components in parts by weight: 10-20 parts of natural vitamin E, 50-80 parts of glycerol butyrate, 50-100 parts of lactobacillus, 30-50 parts of streptococcus faecalis, 5-20 parts of glycerol distearate, 18-35 parts of caprylic/capric triglyceride, 8-15 parts of surfactant and 800-1200 parts of water.
2. The compound oral liquid according to claim 1, which is characterized by being prepared by mixing the following components in parts by weight: 15 parts of natural vitamin E, 62 parts of glycerol butyrate, 70 parts of lactobacillus, 35 parts of streptococcus faecalis, 15 parts of glycerol distearate, 25 parts of caprylic/capric triglyceride, 10 parts of surfactant and 1000 parts of water.
3. The compound oral liquid according to claim 1 or 2, wherein the effective viable count of lactobacillus is 10 8 ～10 9 cfu/g; the effective viable count of the streptococcus faecalis is 10 8 ～10 9 cfu/g。
4. The compound oral liquid according to claim 1 or 2, wherein the surfactant is any one of tween 80 and glycerin.
5. The method for preparing the compound oral liquid according to any one of claims 1 to 4, comprising the steps of:
heating and dissolving the glyceryl distearate, cooling to normal temperature, sequentially adding natural vitamin E, glyceryl butyrate, caprylic/capric acid glyceride, lactobacillus, streptococcus faecalis and surfactant, mixing uniformly, adding water with a prescription amount, stirring, and homogenizing under high pressure to obtain the compound oral liquid.
6. The method according to claim 5, wherein the heating dissolution temperature is 40 to 50 ℃.
7. The method according to claim 5, wherein the high-pressure homogenization specific conditions are: pressure of 0.1-0.15 MPa, temperature of 120-130 ℃ and flow rate of 18-22 m 3 /h。
8. The application of the compound oral liquid in preventing diarrhea of piglets according to any one of claims 1-4, wherein the compound oral liquid is prepared by the following steps: (800-1500) is added into water for piglets to drink.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202311616925.4A CN117617390A (en) | 2023-11-30 | 2023-11-30 | Compound oral liquid for treating diarrhea of piglets, and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202311616925.4A CN117617390A (en) | 2023-11-30 | 2023-11-30 | Compound oral liquid for treating diarrhea of piglets, and preparation method and application thereof |
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