CN106922997A - A kind of pig feed additive of efficient gastrointestinal mucosa repair function - Google Patents
A kind of pig feed additive of efficient gastrointestinal mucosa repair function Download PDFInfo
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Abstract
The present invention provides a kind of pig feed additive of efficient gastrointestinal mucosa repair function, and every 100 parts are made up of following raw materials by weight portion：1~6 part of pig's epidermal growth factor, 10~20 parts of active probiotic, 5~15 parts of cell-oligosaccharide, 1~3 part of glutamine dipeptide, 10~25 parts of yeast cell wall extract, 1~3 part of lysozyme, remaining is carrier；Wherein active probiotic include 6~10 parts of VREF, 1~3 part of bacillus subtilis, 1~3 part of Bacillus acidi lactici, 1~2 part of bifidobacterium longum, 1~2 part of streptococcus thermophilus, the total viable count of product reaches 2.0 × 109CFU/g~2.0 × 1011CFU/g；Carrier is any one in glucose, soluble starch, maize cob meal, zeolite powder, two or more.The present invention significantly improves swinery specificity and non-specific immune function, reduces the death rate.
Description
Technical field
The invention belongs to feed additive field, the pig feed of more particularly to a kind of efficient gastrointestinal mucosa repair function is added
Agent.
Background technology
In recent years, developing rapidly with China's pig industry, swine disease prevalence is on the rise, the chemical classes such as antibiotic medicine according to
It is so the first-selection for preventing and treating various diseases, this not only causes a large amount of drug-fast bacterias, the appearance of worm strain, and causes chemicals to exist
Residual in pork and products thereof, greatly infringement is brought to public health and food security.
Disease and drug therapy all damage pig body histoorgan, significant percentage of pig is formed cad pig, deadlock herein
Pig refers to just the pig with dysplasia syndrome.According to statistics, various diseases are up to the ratio that pig becomes cad pig
31.2%.The main clinical manifestation of cad pig is to become thin, and constitution is weak, and anti-adversity ability is poor, and the speed of growth is slow.Cause the master of these cad pigs
It is that each histoorgan is subject to different degrees of damage in pig body to want reason, it is impossible to repaired, especially the destruction of intestines and stomach.
EGF（EGF）It is a kind of multi-functional Porcine HGF, hair is combined by with EGF receptor on cell membrane
Wave physiological action.Research shows：The various kinds of cell such as epidermal cell, fibroblast, endothelial cell and smooth muscle cell it is thin
All contain EGF receptor, wherein epidermal cell content highest on after birth.EGF close to after cell with cell membrane on EGEF acceptor knots
Close, promote cell interior that the biochemical cascade of a series of complex occurs so that RNA, DNA and protein synthesis increase, most
Promote cell growth breeding eventually, accelerate cell metabolism.People's medication field have it is more use, but pig health field, not
Once had been reported that.
The enteron aisle of pig is the main place that food digestion absorbs, and the healthy growth to maintaining pig has important effect.
Enteron aisle, the various nutriments in chyme are broken down into various small-molecule substances, and blood and lymph are absorbed into through enteron aisle fine hair,
Utilized for body each several part.In addition, during the defence of body, enteron aisle also plays an important role.Improve pig intestinal health,
Be conducive to improving feed digestibility, improve the use value of feed, while the immunity of pig can also be strengthened, pig is grown
There is active influence.Wherein enteron aisle diarrhoea it is most common, Intestinal epithelial cells denaturation, necrosis, come off, intestinal absorption ability drop
Low, the chyme of fully digestion does not enter large intestine, and the concentration that the generation of large intestine microbial fermentation is harmful to acid increases, on big enteral osmotic pressure
Rise, water penetrates into large intestine and causes diarrhoea, and nutriment, electrolyte, body fluid are seriously lost.Microecological balance destruction be also reason it
One：Treatment diarrhoea needs the reason for considering.
Current existing technology is mostly growing in concern intestines function of piglings, for cad pig, the life in ill stage
Growing and fattening pigs gastrointestinal function long is rarely reported, and its raw material mainly probiotics for using, is still being unable to maintain that intestines and stomach just
Chang Gongneng, the resistance against diseases for improving body.
The content of the invention
Defect based on prior art, it is an object of the invention to provide a kind of feed addition containing Polyene Phosphatidylcholine
Agent, belongs to pig feed additive technical field.
Disease and drug therapy all damage pig body histoorgan, significant percentage of pig is formed cad pig, deadlock herein
Pig refers to just the pig with dysplasia syndrome.The present invention provides a kind of cad pig intestinal regeneration factor, enteron aisle of being based on and exempts from
The basic principle of epidemic disease, prebiotics and enteral microecological formulation, can effectively repair cad pig chitling mucosa injury, promote cad pig growth
The feed addictive of energy, promotes cad pig intestinal health and immunity, so as to improve cad pig survival rate and the speed of growth.
In order to realize foregoing invention purpose, its specific technical scheme is as follows：
A kind of feed addictive of efficient gastrointestinal mucosa repair function, every 100 parts are made up of following raw materials by weight portion：
Pig's epidermal growth factor 1-6 parts,
Active probiotic 10-20 parts,
Cell-oligosaccharide 5-15 parts,
Glutamine dipeptide 1-3 parts,
Yeast cell wall extract 10-25 parts,
Lysozyme 1-3 parts,
Balance of carrier；
Wherein：
Active probiotic includes VREF 6-10 parts,
Bacillus subtilis 1-3 parts,
Bacillus acidi lactici 1-3 parts,
Bifidobacterium longum 1-2 parts,
Streptococcus thermophilus 1-2 parts,
The total viable count of product reaches 2.0 × 109CFU/g~2.0 × 1011CFU/g；
Carrier is any one in glucose, soluble starch, maize cob meal, zeolite powder, two or more.
Preferably, every 100 parts are made up of following raw materials by weight portion：
2 parts of pig's epidermal growth factor,
15 parts of active probiotic,
10 parts of cell-oligosaccharide,
2 parts of glutamine dipeptide,
15 parts of yeast cell wall extract,
2 parts of lysozyme,
Balance of carrier；
Wherein described active probiotic includes 8 parts of VREF, 2 parts of bacillus subtilis, 2 parts of Bacillus acidi lactici, bifidobacterium longum 2
Part, 1 part of streptococcus thermophilus, the total viable count of product reaches 2.0 × 1010 CFU/g。
A kind of preparation method of the feed addictive of above-mentioned efficient gastrointestinal mucosa repair function, including step：
Weigh the pig's epidermal growth factor of recipe quantity, cell-oligosaccharide, glutamine dipeptide, yeast cell wall extract and carrier；
First pig's epidermal growth factor, cell-oligosaccharide, glutamine dipeptide, yeast cell wall extract and carrier are mixed,
Obtain mixture A；
Then obtained final product after adding mixture A well mixed all active probiotics, lysozyme.
One boar food, it is characterised in that by weight percentage, its contain 0.1~0.5% any one of as described above
A kind of feed addictive of efficient gastrointestinal mucosa repair function.
The pig's epidermal growth factor is provided by animal institute of Hua Zhong Agriculture University.
VREF can settle down after entering enteron aisle at specific position, and can breed rapidly, intestinal mucosa is risen barrier with
Protective effect, effectively prevents harmful microbe from invading, and infectious and non-infection diarrhoea is had certain effect.Can also prevent
With improvement diarrhoea, enteric infection, the intestinal mucosa damage caused using antibiotic, constipation, indigestion are sent out extremely in enteron aisle
The illnesss such as ferment, malnutritive, enteritis, poor appetite, abdominal distension.
Streptococcus thermophilus to the tolerance of hydrochloric acid in gastric juice, to the tolerance of cholate, the suppression to pathogenic entero becteria, streptococcus thermophilus
The colony diameter of clostridium difficile, salmonella typhimurium, Escherichia coli can be made to reduce about 30%；Staphylococcus aureus, monokaryon can be made
Hyperplasia Listeria, the colony diameter of C.perfringens reduce about 20%.Streptococcus thermophilus can be in the courage of higher concentration
Survived in juice, so the distal end of small intestine should be reached from the infringement of bile in vivo.
Bifidobacterium longum has the disorderly effect of adjustment function of intestinal canal.Can pre- anti-diarrhea, reduction constipation, i.e. bidirectional modulation.
This regulation can play the effect for preventing and treating various intestines problems.Bacillus acidi lactici can prevent invasion of the pathogen to enteron aisle
And field planting, suppress pathogen, it is anti-infective, the microecological balance of enteron aisle, prevention and the generation of suppression tumour are maintained, enhancing body is exempted from
Epidemic disease power, promotes digestion, synthesizing amino acid and vitamin, reduces cholesterol, suppresses endotoxic production etc..On lysozyme is simultaneously
State the MF of beneficial bacterium.
Gut barrier is mainly made up of biological barrier, mechanical barrier, immunization barrier.Biological barrier is have to external bacterial strain
It is colonized the normal parasitism flora of enteral of resistant function.The present invention provides above-mentioned including VREF, bacillus subtilis, lactic acid bar
Micro- space structure of the gut-active probiotics such as bacterium, bifidobacterium longum, streptococcus thermophilus and host forms one and interdepends
The microecosystem for interacting again.Under normal conditions, micropopulation constitutes one to antiviral important in enteron aisle
Protective barrier.After the stability of this Tiny ecosystem flora is destroyed, intestinal colonisation resistance is greatly lowered, and can cause enteron aisle
In potential pathogen (including conditioned pathogen) field planting and invasion.
Mechanical barrier refers to complete intestinal mucosa tightly attached to each other, mainly by Intestinal epithelial cells and
Closely connecting and composing between it.Gut barrier is mostly important with mechanical barrier, and its architecture basics is on complete intestinal mucosa
Tight connection between chrotoplast and epithelial cell.Intestinal epithelial cells, intercellular tight junction and mycoderm under normal circumstances
Three constitutes the mechanical barrier of enteron aisle, can effectively prevent the harmful substances such as bacterium and endotoxin from entering blood through intestinal mucosa.Stomach
Generation, the evolution of intestines problem can all cause the damage of intestinal mucosa, and then destroy gut barrier, and what is aggravated disease enters
Exhibition.
Pig's epidermal growth factor is a kind of nutrition polypeptide being made up of 53 amino acid, and its major function is to promote cell
Hyperplasia, participates in hyperplasia, maturation, the differentiation of gastrointestinal epithelial cell, and growing for intestines and stomach is adjusted in physiological conditions, has in addition
Nutritious and protection intestines and stomach effect.Pig's epidermal growth factor is used as gastrointestinal mucosa reparative factor：Promote Intestinal epithelial cells
Divide a word with a hyphen at the end of a line and then promote the reparation of mucous membrane, strengthen intestinal mucosa mechanical barrier.
Immunization barrier is by intestinal mucosa lymphoid tissue（Including lymphonodi mesenterici, liver Kupper cells）It is thin with enteron aisle entoplasm
Intracrine type antibody (sIgA) is constituted.The glutamine dipeptide that the present invention is provided：Can safeguard and repair function of intestinal mucosa barrier in patient（For
Enteron aisle provides a large amount of abilities）, promote the development such as pig gut associated lymphatic tissue, improve intestinal immunity, so as to promote pig to daily ration
Digesting and assimilating for middle nutritional ingredient, improves the general level of the health and growth performance of piglet, while glutamine dipeptide compares glutamine
More preferably, bioavilability is higher for stability.In gastrointestinal mucosa, 25% is lymphoid tissue, and they are exempted from by cellular immunity and body fluid
Epidemic disease is acted on, to prevent injury of the Pathaic antygen to human body.By gut-associated lymphoid tissue（GALT）The specific secretion of generation
Type immunoglobulin（S-IgA）Gram-negative bacteria can be optionally coated with into enteron aisle, antigen antibody complex is formed, hindered
Bacterium is combined with epithelial receptor, while stimulating enteron aisle mucous secretion and accelerating the flowing of rete malpighii, can effectively prevent
Adhesion of the bacterium to intestinal mucosa.
Cell-oligosaccharide can promote the beneficial microorganisms such as Bifidobacterium, Bacillus acidi lactici to breed as prebiotics, while suppression
Escherichia coli processed and clostridium etc. breed, and improve intestinal microecology, improve pig non-specific immunity, and cell-oligosaccharide is in intestinal fermentation
SCFA is produced, intestinal pH is reduced.
Yeast cell wall extract main component is polypeptide, amino acid, flavour nucleotide, B family vitamin and trace element
Deng the material of active skull cap components.Contain a large amount of microproteins in yeast cell wall extract, nucleic acid substances and feature are few
Sugar etc. is beneficial to the material of animal health, can not only promote the gastral development of body, improve endogenous digestive ferment secretion and
Vigor, the absorption function for improving intestinal mucosa, improve digestive function, and improve pig normal flora quantity.
Foregoing invention is formulated three-dimensional integrated, three-dimensional reparation function of intestinal mucosa barrier in patient.
Beneficial effects of the present invention are as follows：
1st, above-mentioned several raw materials are carried out prescription by the present invention, and each raw material synergy promotes the benign development in chitling road, reduces enteron aisle
Crypt depth, increases villi height, improves absorptivity of the enteron aisle to nutriment, increases efficiency of feed utilization.
2nd, swinery specificity and non-specific immune function are significantly improved, the death rate is reduced.
3rd, acidproof, bile tolerance, and with good enteron aisle adhesion and reproductive capacity, Tiny ecosystem is put down in quick improvement enteron aisle
Weighing apparatus, is obviously improved the feed intake of market pig and grows, and can promote ill cad pig function of intestinal canal reparation, improves intestine immunity work(
Can, so as to promote to digest and assimilate nutritional ingredient in daily ration, the general level of the health and growth performance of swinery are improved, reduce in cultivating
The excretion of organic matter and mineral matter, effectively reduces water pollution.
4th, this product selects high activity bacterial strain, adds suitable prebiotic component, and organic complex is formed, and can promote bifid bar
The beneficial microorganisms such as bacterium, Bacillus acidi lactici are bred, while suppressing the propagation such as Escherichia coli and clostridium, improve intestinal microecology, together
When cell-oligosaccharide intestinal fermentation produce SCFA, reduce intestinal pH, promote enterocinesia prevent pathogen to be colonized, secrete
Bacteriocin suppresses the growth of pathogen.
5th, dividing a word with a hyphen at the end of a line and then promoting the reparation of mucous membrane, enhancing gut barrier for Intestinal epithelial cells is promoted.
6th, above-mentioned all raw materials are according to proportioning coordinated, biological barrier, mechanical barrier, immune screen from gut barrier
Gastrointestinal mucosa function is repaired in terms of barrier etc. three, it is comprehensive, play the effect treated both principal and secondary aspect of disease.
The present invention provide it is a kind of be based on the cad pig intestinal regeneration factor, intestine immunity, prebiotics and enteral microecological formulation
Basic principle, can effectively repair cad pig intestinal mucosa injury, promote the feed addictive of cad pig growth performance, promote cad pig enteron aisle to be good for
Health and immunity, so as to improve cad pig survival rate and the speed of growth.
A kind of feed addictive preparation method of efficient gastrointestinal mucosa repair function of the invention, process is simple, operation side
Just, it is adapted to large-scale industrial production.
Specific embodiment
Specific embodiment of the invention is illustrated with reference to specific embodiment, but following examples are used only in detail
The present invention is illustrated, the scope of the present invention is limited never in any form.
The present invention is further described below by way of specific embodiment.
Embodiment 1
A kind of pig feed additive of efficient gastrointestinal mucosa repair function, every 100 parts are made up of following raw materials by weight portion：Pig
1 part of EGF, 10 parts of active probiotic, 5 parts of cell-oligosaccharide, 1 part of glutamine dipeptide, yeast cell wall extract 10
Part, 1 part of lysozyme, remaining is carrier；Wherein described active probiotic includes 6 parts of VREF, 1 part of bacillus subtilis, breast
1 part of acidfast bacilli, 1 part of bifidobacterium longum, 1 part of streptococcus thermophilus, the total viable count of product reaches 2.0 × 109CFU/g；Described
Carrier is soluble starch.
A kind of preparation method of the pig feed additive of efficient gastrointestinal mucosa repair function, including：
Weigh the pig's epidermal growth factor of recipe quantity, cell-oligosaccharide, glutamine dipeptide, yeast cell wall extract and carrier；
First pig's epidermal growth factor, cell-oligosaccharide, glutamine dipeptide, yeast cell wall extract and carrier are mixed, is obtained mixed
Compound A；
Finally all active probiotics, lysozyme is obtained final product after adding mixture A well mixed.
Embodiment 2
A kind of pig feed additive of efficient gastrointestinal mucosa repair function, every 100 parts are made up of following raw materials by weight portion：Pig
2 parts of EGF, 15 parts of active probiotic, 10 parts of cell-oligosaccharide, 2 parts of glutamine dipeptide, yeast cell wall extract
15 parts, 2 parts of lysozyme, remaining is carrier；Wherein described active probiotic include 8 parts of VREF, 2 parts of bacillus subtilis,
2 parts of Bacillus acidi lactici, 2 parts of bifidobacterium longum, 1 part of streptococcus thermophilus, the total viable count of product reaches 2.0 × 1010CFU/g；It is described
Carrier be zeolite powder.
A kind of preparation method of the pig feed additive of efficient gastrointestinal mucosa repair function, including：
Weigh the pig's epidermal growth factor of recipe quantity, cell-oligosaccharide, glutamine dipeptide, yeast cell wall extract and carrier；
First pig's epidermal growth factor, cell-oligosaccharide, glutamine dipeptide, yeast cell wall extract and carrier are mixed, is obtained mixed
Compound A；
Finally all active probiotics, lysozyme is obtained final product after adding mixture A well mixed.
Embodiment 3
A kind of pig feed additive of efficient gastrointestinal mucosa repair function, every 100 parts are made up of following raw materials by weight portion：Pig
6 parts of EGF, 20 parts of active probiotic, 15 parts of cell-oligosaccharide, 3 parts of glutamine dipeptide, yeast cell wall extract
25th, 3 parts of lysozyme, remaining is carrier；Wherein described active probiotic includes 10 parts of VREF, 3 parts of bacillus subtilis, breast
3 parts of acidfast bacilli, 2 parts of bifidobacterium longum, 2 parts of streptococcus thermophilus, the total viable count of product reaches 2.0 × 1011CFU/g；Described
Carrier is glucose.
A kind of preparation method of the pig feed additive of efficient gastrointestinal mucosa repair function, including：
Weigh the pig's epidermal growth factor of recipe quantity, cell-oligosaccharide, glutamine dipeptide, yeast cell wall extract and carrier；
First pig's epidermal growth factor, cell-oligosaccharide, glutamine dipeptide, yeast cell wall extract and carrier are mixed,
Obtain mixture A；
Finally all active probiotics, lysozyme is obtained final product after adding mixture A well mixed.
Effect experiment
1 materials and methods
Plant of experiment selection Hubei Shayang County average weight is " DLY " fattening pig 160 of 50kg or so, and infection is popular
Property diarrhoea after recover the stage, be randomly divided into 4 groups, every group of 5 repetitions, each repeats 8 pigs, including a blank pair
According to group and 3 test groups.Blank control group daily ration without obtained any additive in embodiment 1-3, remaining 3 test group
Swine rationses add the embodiment 1-3 of 0.2% ratio respectively obtained in additive, live pig free choice feeding and drinking-water, routinely carry out
Immune and expelling parasite, observes and records the mental status of pig diarrhoea, influenza and pig daily in experimental period.Experimental period 21d.Raise
During, each group pig incidence is counted.At the end of feeding experiment, growth performance, diarrhea rate to pig, immunity
Index and enteron aisle index are analyzed.Data statistic analysis test data carries out statistical analysis using SPSS19.0 statistical softwares,
Result see the table below.
Average daily gain (average daily feed intake, ADFI), average daily gain (average
Daily gain, ADG) and feedstuff-meat ratio (FCR), and the incidence of disease of viewing test pig etc..
Result of the test shows：Feed addictive of the present invention is added in the pig feed in ill pig rehabilitation stage, can effectively be repaiied
Multiple chitling mucosa injury, promotes pig intestinal health and immunity, effectively improves the daily gain of pig, reduces feed-weight ratio, reduces dead
Rate and diarrhea rate, therefore be worthy to be popularized.
Finally, in addition it is also necessary to it is noted that listed above is only several specific embodiments of the invention.Obviously, this hair
It is bright to be not limited to above example, there can also be many deformations.One of ordinary skill in the art can be from present disclosure
The all deformations directly derived or associate, are considered as protection scope of the present invention.
Claims (4)
1. a kind of feed addictive of efficient gastrointestinal mucosa repair function, it is characterised in that every 100 parts by following raw material by weight
Number is constituted：
Pig's epidermal growth factor 1-6 parts,
Active probiotic 10-20 parts,
Cell-oligosaccharide 5-15 parts,
Glutamine dipeptide 1-3 parts,
Yeast cell wall extract 10-25 parts,
Lysozyme 1-3 parts,
Balance of carrier；
Wherein：
The active probiotic includes VREF 6-10 parts,
Bacillus subtilis 1-3 parts,
Bacillus acidi lactici 1-3 parts,
Bifidobacterium longum 1-2 parts,
Streptococcus thermophilus 1-2 parts,
The total viable count of product reaches 2.0 × 109CFU/g~2.0 × 1011CFU/g；
Described carrier is any one in glucose, soluble starch, maize cob meal, zeolite powder, two or more.
2. a kind of feed addictive of efficient gastrointestinal mucosa repair function, it is characterised in that every 100 parts by following raw material by weight
Number is constituted：
2 parts of pig's epidermal growth factor,
15 parts of active probiotic,
10 parts of cell-oligosaccharide,
2 parts of glutamine dipeptide,
15 parts of yeast cell wall extract,
2 parts of lysozyme,
Balance of carrier；
Wherein described active probiotic includes 8 parts of VREF, 2 parts of bacillus subtilis, 2 parts of Bacillus acidi lactici, bifidobacterium longum 2
Part, 1 part of streptococcus thermophilus, the total viable count of product reaches 2.0 × 1010 CFU/g。
3. a kind of preparation method of the feed addictive of efficient gastrointestinal mucosa repair function as claimed in claim 1 or 2, it is special
Levy and be, including：
Weigh the pig's epidermal growth factor of recipe quantity, cell-oligosaccharide, glutamine dipeptide, yeast cell wall extract and carrier；
First pig's epidermal growth factor, cell-oligosaccharide, glutamine dipeptide, yeast cell wall extract and carrier are mixed,
Obtain mixture A；
Then obtained final product after adding mixture A well mixed all active probiotics, lysozyme.
4. a boar food, it is characterised in that by weight percentage, its contain 0.1~0.5% as in claims 1 to 3
The feed addictive of a kind of efficient gastrointestinal mucosa repair function described in any one.
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| CN107373027A (en) * | 2017-08-01 | 2017-11-24 | 中国农业科学院饲料研究所 | One kind is born to 2 week old suckling pig formulation liquid feeds and its application |
| CN107594148A (en) * | 2017-09-28 | 2018-01-19 | 刘军 | A kind of beef ox fattening feed and preparation method thereof |
| CN108308429A (en) * | 2018-04-13 | 2018-07-24 | 安徽天邦生物技术有限公司 | One boar composite probiotics ferment concentrated feed and preparation method thereof |
| CN108464402A (en) * | 2018-04-02 | 2018-08-31 | 四川铁骑力士实业有限公司 | A kind of mixed feed for 30-60kg coal pigs |
| CN109965100A (en) * | 2019-05-06 | 2019-07-05 | 北京绿摇饲料科技有限公司 | A kind of feed addictive and its application method |
| CN114947134A (en) * | 2022-05-06 | 2022-08-30 | 河北一然生物科技股份有限公司 | Application of streptococcus thermophilus S131 in improving intestinal health and regulating intestinal flora |
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| CN107594148A (en) * | 2017-09-28 | 2018-01-19 | 刘军 | A kind of beef ox fattening feed and preparation method thereof |
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