CN109965100A - A kind of feed addictive and its application method - Google Patents
A kind of feed addictive and its application method Download PDFInfo
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- CN109965100A CN109965100A CN201910372105.2A CN201910372105A CN109965100A CN 109965100 A CN109965100 A CN 109965100A CN 201910372105 A CN201910372105 A CN 201910372105A CN 109965100 A CN109965100 A CN 109965100A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Birds (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Physiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Abstract
A kind of feed addictive and its application method, the present invention, which discloses, kind to be adjusted intestine of young pigs epithelial cell turnover and promotes a feed addictive for intestine of young pigs injury repair.The feed addictive is made of active constituent and matrix；The composition of active constituent is as follows: 3-8 parts of EGF pre-mixing agent, 3-7 parts of GLP-2 pre-mixing agent, 15-25 parts of Coating sodium butyrate, 15-25 parts of glycylglutamine, 7-14 parts of yeast nucleotides, 3-6 parts of glutathione, 4-6 parts of sanguinarine, 2-4 parts of 1,6- diphosphofructose.Active constituent and carrier are uniformly mixed, the feed addictive is obtained.In application, feed addictive is added by the 0.1-0.2% of daily total feed quality on the basis of piglet daily feed formula.The feed addictive, which has the advantages that, can effectively facilitate intestinal epithelial cell proliferation, inhibit epithelial cell shedding apoptosis, reduce intestinal inflammatory and improve enteron aisle oxidative damage, to promote intestine of young pigs injury repair；Without drug ingedient, ecological, environmental protective.
Description
Technical field
The invention belongs to feed additive field, in particular to a kind of adjusting intestine of young pigs epithelial cell turnover and promotion are young
The feed addictive of chitling road injury repair and its application.
Background technique
Intestine of young pigs is not only the vitals of nutrient digestion absorption, while being also a very important defence device
Official, intestinal mucosa form a complicated system by the immune response effect of antigenic activation and tackle numerous in enteric cavity resist
It is former.In natural conditions, weaned piglet age in days (60 ages in days or so) is larger, and intestinal growth is relatively mature, which can
Harmful antigens are fought by immune response, are formed simultaneously the tolerance to harmless antigens.Piglet is adopted mostly in Pig Industry system
With early weaning, intestine of young pigs immune system is not yet reached maturity when wean, is unfavorable for distinguishing harmful intestinal tract and harmless antigens, production
Raw appropriate immune response.And the nutrition supply of weanling pig is changed into rapidly the feeding rich in plant component by the breast milk of animality
Expect, the antigenic substance (such as: glycinin, beta-conglycinin) contained in these vegetable ingredients can stimulate early stage disconnected
Milk intestine of young pigs mucous membrane generates inappropriate immune response, to cause inflammatory reaction.In addition, nutrition is taken the photograph after weaned piglet
Enter amount to reduce rapidly, intestinal mucosa nutrition supply is insufficient, so that intestinal structure and barrier function are damaged, further promotees
Small intestine epithelium is passed through into the antigenic substance in enteric cavity and causes inflammatory reaction.Therefore, early-weaned piglets easily show digestion not
Good, hypoimmunity, diarrhea, growth retardation, even death etc. " early weaning syndrome ".In addition to piglet caused by weaning stress
Outside intestinal tract injury, environmental change, feed conversion, pathogen invasion and long-distance transportation for undergoing in piglet growth course etc. stress
Factor also often results in intestines function of piglings disorder, leads to intestinal tract injury.Intestine of young pigs epithelial cell is that function of intestinal canal is mainly held
Passerby, intestinal epithelial cell are the bases for maintaining function of intestinal canal and injury repair along correct update of crypt-villus axis.It is existing
The means of intestine of young pigs damage are solved mainly by the large dosage addition antibiotic reduction Infection in Piglets cause of disease in feed or drinking-water
The chance of bacterium, but intestine of young pigs damage problem can not be fundamentally solved, and a large amount of uses of antibiotic can be such that pathogen produces
Raw drug resistance, to further threaten the health of animals and humans.Therefore, solving piglet by large dosage of antibiotic usage stress
With apparent limitation, and intestinal epithelial cell proliferation can be effectively adjusted there is no one kind in the prior art and promotes enteron aisle
The nutritional feed additive of injury repair.
Summary of the invention
The primary purpose of the present invention is that overcoming defect of the existing technology, it is thin to provide a kind of adjusting intestine of young pigs epithelium
Born of the same parents update and promote feed addictive and its application of intestine of young pigs injury repair.
In order to achieve the above objectives, solution of the invention is:
A kind of feed addictive, with 100 listed as parts by weight of total amount, the feed addictive includes:
| EGF pre-mixing agent | 3-8 parts |
| GLP-2 pre-mixing agent | 3-7 parts |
| Coating sodium butyrate | 15-25 parts |
| Glycylglutamine | 15-25 parts |
| Yeast nucleotides | 7-14 parts |
| Glutathione | 3-6 parts |
| Sanguinarine | 4-6 parts |
| 1,6- diphosphofructose | 2-4 parts |
| Carrier | 21-32 parts |
。
Preferably, with 100 listed as parts by weight of total amount, the feed addictive includes:
| EGF pre-mixing agent | 5 parts |
| GLP-2 pre-mixing agent | 5 parts |
| Coating sodium butyrate | 20 parts |
| Glycylglutamine | 20 parts |
| Yeast nucleotides | 10 parts |
| Glutathione | 5 parts |
| Sanguinarine | 5 parts |
| 1,6- diphosphofructose | 3 parts |
| Carrier | 27 parts |
| It is total | 100 parts |
。
Preferably, EGF content is 5g/kg in the EGF pre-mixing agent.
Preferably, GLP-2 content is 5g/kg in the GLP-2 pre-mixing agent.
Preferably, the carrier is defatted rice bran, be it is common in feed or feed addition, for a certain extent
Dilution and adsorption of effective component are conducive to preferably be uniformly mixed during following process.
A kind of application method of feed addictive, feed addictive are added into feed according to the ratio of 0.2wt%, mixing
Feeding after uniformly.
The present invention have the advantage that and the utility model has the advantages that
Component EGF and GLP-2 can promote the proliferation of intestinal epithelial cell in feed addictive provided by the invention, provide
The cell origin of intestinal tract injury reparation；Glutathione can improve enteron aisle oxidative damage, reduce the anoikis of epithelial cell,
To adjust intestinal epithelial cell renewal process.
Component glycylglutamine can be metabolized for intestinal epithelial cell and provide energy in feed addictive provided by the invention
Amount maintains function of intestinal canal, and yeast nucleotides can provide necessary nutrition for the proliferation of epithelial cell, promotes epithelial cell proliferation；
Fructose 1,6-diphosphate can adjust intestinal epithelial cell metabolism, promote epithelial cell proliferation.
The present invention provides component Coating sodium butyrate fixed point enteric release after piglet in feed addictive, is enteric epithelium after piglet
Cell provides energy, while can promote hindgut endocrine cells secrete GLP-2, further promotes intestinal epithelial cell proliferation.
Component sanguinarine has good antigen effect in feed addictive provided by the invention, inhibits intestinal tract injury part
Inflammatory reaction improves function of intestinal canal.
The present invention promotes intestinal epithelial cell proliferation by a system schema, inhibits intestinal epithelial cell anoikis,
The necessary nutrition of epithelial cell proliferation and metabolism is provided simultaneously and inhibits intestinal inflammatory, promotes intestinal tract injury reparation to reach
Purpose.
The present invention is free of drug ingedient, ecological, environmental protective.
Specific embodiment
Embodiment 1
A kind of feed addictive for adjusting intestine of young pigs epithelial cell turnover and promoting intestine of young pigs injury repair, substance
Composition and ratio are shown in Table 1.
Table 1
| Material name | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| EGF pre-mixing agent | 5 parts | 3 parts | 8 parts | 6.5 part | 4.8 part |
| GLP-2 pre-mixing agent | 5 parts | 7 parts | 3 parts | 4.2 part | 5.6 part |
| Coating sodium butyrate | 20 parts | 15 parts | 25 parts | 22 parts | 18.5 parts |
| Glycylglutamine | 20 parts | 25 parts | 15 parts | 18 parts | 21.5 parts |
| Yeast nucleotides | 10 parts | 7 parts | 14 parts | 11.9 parts | 9.5 part |
| Glutathione | 5 parts | 3 parts | 6 parts | 5.1 part | 4.1 part |
| Sanguinarine | 5 parts | 6 parts | 4 parts | 4.6 part | 5.3 part |
| 1,6- diphosphofructose | 3 parts | 2 parts | 4 parts | 2.4 part | 3.3 part |
| Carrier | 27 parts | 32 parts | 21 parts | 25.3 parts | 27.4 parts |
| It is total | 100 parts | 100 parts | 100 parts | 100 parts | 100 parts |
Embodiment 2
A kind of feed addictive for adjusting intestine of young pigs epithelial cell turnover and promoting intestine of young pigs injury repair, substance
Composition and ratio are shown in Table 1.
Embodiment 3
A kind of feed addictive for adjusting intestine of young pigs epithelial cell turnover and promoting intestine of young pigs injury repair, substance
Composition and ratio are shown in Table 1.
Embodiment 4
A kind of feed addictive for adjusting intestine of young pigs epithelial cell turnover and promoting intestine of young pigs injury repair, substance
Composition and ratio are shown in Table 1.
Embodiment 5
A kind of feed addictive for adjusting intestine of young pigs epithelial cell turnover and promoting intestine of young pigs injury repair, substance
Composition and ratio are shown in Table 1.
Embodiment 6
It is a kind of to adjust intestine of young pigs epithelial cell turnover and promote the feed addictive of intestine of young pigs injury repair in piglet
In application, the steps include:
A. by each active principle and carrier investment mixing machine, make to be sufficiently mixed, obtain feed additives products；
B. feed addictive is added into feed according to the ratio of 0.1 (wt) %, piglet can be fed by being uniformly mixed.
Effect detection
3 ages in days (wean of 21 ages in days) diarrhea piglet 49 after weaning are chosen, 7 processing groups, every group of 7 weights are randomly divided into
Multiple, 1 pig of each repetition (single column feeding), as shown in table 2, control group do not add additive of the invention, processing group addition 0.1
(wt) feed addictive of the present invention of % different ratio is tested 4 days by a definite date.This feed addictive is to grice diarrhoea, gut epithelium
The influence of cell Proliferation and anoikis is shown in Table 3.It can be seen that compared with the control group from the test result of table 3, processing group piglet
Diarrhea rate obtain different degrees of improvement, the proliferation index of jejunal epithelium cell obtains different degrees of raising, cell
The index that falls off obtains different degrees of decline.
Table 2
Table 3
| Material name | Control group | Processing 1 | Processing 2 | Processing 3 | Processing 4 | Processing 5 | Processing 6 |
| Diarrhea rate | 78.55 | 42.06 | 51.52 | 54.18 | 63.04 | 47.53 | 54.09 |
| Proliferating antigen Ki67 | 16.24 | 25.81 | 21.23 | 23.87 | 19.38 | 26.34 | 22.02 |
| Cell detachment index | 0.36 | 0.24 | 0.27 | 0.28 | 0.24 | 0.23 | 0.26 |
。
Embodiment 7
It is a kind of to adjust intestine of young pigs epithelial cell turnover and promote the feed addictive of intestine of young pigs injury repair in piglet
In application, the steps include:
A. by each active principle and carrier investment mixing machine, make to be sufficiently mixed, obtain feed additives products；
B. feed addictive is added into feed according to the ratio of 0.2 (wt) %, piglet can be fed by being uniformly mixed.
Effect detection
35 age in days piglet 48 is chosen, 6 processing groups, every group of 8 repetitions, Mei Gechong are randomly divided into according to weight and gender
Multiple 1 pig (single column feeding) test schedules to last 7d.All piglets are injected intraperitoneally according to 10mg/kg BW dosage on the day of on-test
Diquat dibromide (diquat).Each processing group is as shown in table 4, and control group does not add additive of the invention, processing group addition 0.2
(wt) feed addictive of the present invention of % different ratio.It can be seen that compared with the control group from 5 test result of table, processing group is young
Swine intestinal epithelium cells proliferation index increases, and cell detachment index reduces, intestinal structure (height of naps and Crypt depth)
It significantly improves, enteron aisle oxidative damage (mda content) and inflammation (inflammatory factor TNFa and IL-6) are also improved:
Table 4
Table 5
Claims (6)
1. a kind of feed addictive, which is characterized in that with 100 listed as parts by weight of total amount, the feed addictive includes:
。
2. a kind of feed addictive as described in claim 1, which is characterized in that with 100 listed as parts by weight of total amount, the feeding
Feed additives include:
。
3. a kind of feed addictive as described in claim 1-2 any claim, which is characterized in that the EGF premix
EGF content is 5g/kg in agent.
4. a kind of feed addictive as described in claim 1-2 any claim, which is characterized in that the GLP-2 is pre-
GLP-2 content is 5g/kg in mixture.
5. a kind of feed addictive as described in claim 1-2 any claim, which is characterized in that the carrier is de-
Rouge rice bran.
6. a kind of application method of feed addictive, which is characterized in that feed addictive adds according to the ratio of (0.1-0.2) wt%
It is added in feed, feeds after mixing.
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|---|---|---|---|
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|---|---|---|---|
| CN201910372105.2A CN109965100A (en) | 2019-05-06 | 2019-05-06 | A kind of feed addictive and its application method |
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| Publication Number | Publication Date |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111700161A (en) * | 2020-06-30 | 2020-09-25 | 芜湖英特菲尔生物制品产业研究院有限公司 | Preparation and application of recombinant porcine epidermal growth factor |
| CN112369518A (en) * | 2020-11-09 | 2021-02-19 | 广东省农业科学院动物科学研究所 | Piglet feed and application thereof |
| CN113875896A (en) * | 2021-10-11 | 2022-01-04 | 浙江省农业科学院 | Feed additive for treating and preventing intestinal injury of pigs |
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Application publication date: 20190705 |