CN103005204B - Nutritional anti-stress bioremediation composition for pigs and preparation method thereof - Google Patents
Nutritional anti-stress bioremediation composition for pigs and preparation method thereof Download PDFInfo
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- CN103005204B CN103005204B CN201210553201.5A CN201210553201A CN103005204B CN 103005204 B CN103005204 B CN 103005204B CN 201210553201 A CN201210553201 A CN 201210553201A CN 103005204 B CN103005204 B CN 103005204B
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Abstract
The invention discloses a nutritional anti-stress bioremediation composition for pigs and a preparation method thereof. The composition comprises the following components: water-soluble Vitamin A powder, water-soluble Vitamin D3, water-soluble Vitamin E, water-soluble Vitamin K3, Vitamin B1, Vitamin B2, Vitamin B6, Vitamin B12, biotin, folic acid, nicotinic acid amine, calcium pantothenate, Vitamin C, carnitine, Beta-carotene, lysine, methionine, threonine, tryptophane, arginine, fructooligosccharide, glutamine, lipoic acid and anhydrous dextrose. The invention also relates to the preparation method of the composition, which comprises the step that after all the components are uniformly mixed, the final product (the nutritional anti-stress bioremediation composition for pigs) can be obtained. According to the invention, the oxidation prevention method is adopted to inhibit the incidence and development processes of stress of pigs, and the bioremediation technology is adopted to repair oxidative damages. The composition has superior effects and stable properties, does not contain any antibiotic additive, can reduce loss caused by stress syndrome and has a better application prospect.
Description
Technical field
The present invention relates to a kind of feed addictive and preparation method thereof, specifically, relate to a boar with trophism anti-stress with bioremediation composition and preparation method thereof.
Background technology
The fast development of large scale of pig farm industry, when bringing revolutionary variation to pig industry, also exposes the problem that this aquaculture model brings---and stress syndrome.Stress harm just becoming increasingly conspicuous and becoming and hinder Pig Industry industry and develop one of topmost problem.At present, herding occurs in producing survival rate is low, the incidence of disease is high, degradation is invariably closely related therewith under livestock products quality.
In scale herding is produced, livestock and poultry usually can produce in feeding and management, environmental change, feed nutrition, immunization therapy and transportation stress.As overheated, excessively cold environment temperature, the toxic and harmful in animal house, diet nutrient is uneven, the mycotoxin in feed, and subimbition and water quality are unhygienic, wean, turn that group, stocking density are excessive, transportation, immunity or treatment etc.Meanwhile, modern farming enterprise's is produced the production model of pursuing high investment high production, adopts high energy high protein ration and adds multiple feed addictive, and the metabolic rate of body improves greatly, and free radical produces in a large number, and free radical surely weighs destroyed; And at present the pig variety of cultivation mostly is and cultivates through the seed selection of height, production performance is high, but oxidation resistance do not improved accordingly, causes the sensitiveness of environment to external world to strengthen, and oxidative stress inevitably occurs, and cause oxidative damage.
The animal intestinal main place that still nutrient digestion does not absorb, or the first barrier of defence in body, its general level of the health is being related to integral animal health and the level of production and efficiency.Meanwhile, enteron aisle is also at first impaired center organ, and acute and lasting stress be by producing the GI oxidative stress of free yl induction, and under oxidative stress status, body blood is redistributed, and intestines and stomach blood flow obviously reduces.In Ischemia-Reperfusion Injury, by xanthine oxidase/hypoxanthine system intestinal cell, produce at short notice a large amount of active oxygens, destroy enteron aisle fluff structures, cause intestinal mucosa epithelial permeability to improve, gut barrier function obstacle, not only affects animal to the digestion of nutriment, absorption and transhipment, and bacterium and Endotoxin Translocation occur, improve the pathogenic of animal, reduce the premunition of animal.
There are some researches show, pig stress reduce the requirement of nutrient the phase, and stress be the amortization period in the later stage, in order to repair impaired histoorgan, the synthetic increase of synthetic increase, the especially protein of nutriment, pig significantly increases the requirement of the nutriments such as amino acid.
At present, for pig stress syndrome, a series of technology and product have been developed, as neuroleptanalgesiss class sedative, electrolyte, trace element, Chinese herbal medicine, vitamin preparation, antibiotic etc., be mainly by extra interpolation nutriment or antibiotic etc. to offset the harm stress causing, and to stress essence and the special dietary of stress damage reparation need to lack method.
Summary of the invention
For defect of the prior art, the object of this invention is to provide a boar with trophism anti-stress with bioremediation composition and preparation method thereof, with anti-oxidation method suppress pig stress generation and evolution, with biological restoration, the oxidative damage having occurred is repaired, provide that a kind of effect is good, stable performance containing antibiotic pig with trophism anti-stress with biological restoration additive, to reduce in Swine Production the loss stress syndrome causing, there is good application prospect.
First aspect, the present invention relates to a boar with trophism anti-stress with bioremediation composition, described composition comprises each component of following parts by weight:
Preferably, described composition comprises each component of following parts by weight:
Preferably, described composition comprises each component of following parts by weight:
Second aspect, the invention still further relates to aforementioned pig with trophism anti-stress with the preparation method of bioremediation composition, after described method comprises the steps: described each component evenly to mix, get final product end product pig with trophism anti-stress with bioremediation composition.
The invention has the beneficial effects as follows: the present invention is according to the theory of Free Radical Biology, adopt multiple antioxidant as formation antioxidant networks such as VA, VE, VC, beta carotene and lipoic acids, due to the synergy between antioxidant, greatly strengthened the oxidation resistance of pig, SOD enzyme and GSH-Px enzymatic activity are showing and are improving in pig body, NO free radical and mda content are showing and are reducing, and significantly alleviate the stress reaction of pig; Stress time body feed intake can decline, metabolism can take a turn for the worse, catabolism can be greater than anabolism, the ability of synthesizing amino acid declines, much amino acid that at ordinary times can be synthetic also can lack, lysine supplement, methionine, threonine, tryptophan and arginine etc. can promote amino acid whose balance, the anabolism of Enhancin matter; Animal occur stress time the requirement of vitamin is increased, especially stress time animal intestinal microecological balance destroy, the synthetic vitamin of enteric microorganism reduces, and adds VD
3, VK
3, VB
1, VB
2, VB
6, VB
12, biotin, folic acid, niacinamide usp, calcium pantothenate and carnitine can meet the needs of animal to vitamin; Supplementary FOS is the microecological balance of regulating intestinal canal effectively, promotes the abilities of digestive and absorption of enteron aisle.Supplement the synergies such as several amino acids, multivitamin and glutamine, promotion stress convalescent biological restoration ability, improves the healthy and growth of pig.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is described in detail.Following examples will contribute to those skilled in the art further to understand the present invention, but not limit in any form the present invention.It should be pointed out that to those skilled in the art, without departing from the inventive concept of the premise, can also make some distortion and improvement.These all belong to protection scope of the present invention.
embodiment 1-6
Embodiment of the present invention 1-6 relate to pig with trophism anti-stress with bioremediation composition, each component of each embodiment is by described in following table 1, table 1 is the concrete formula (unit: kg) of embodiment of the present invention 1-6.
Embodiment of the present invention 1-6 also relate to aforementioned pig with trophism anti-stress with the preparation method of bioremediation composition, preparation method comprises the steps: accurately to weigh as each component in following table 1, after mixing, get final product end product pig with trophism anti-stress with bioremediation composition, then end product is checked to its granularity, color and luster and mixture homogeneity, qualified rear packing.
Table 1
| ? | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 |
| Solvisyn-A powder | 10.0 | 40.0 | 16.0 | 25 | 22 | 28.0 |
| Water soluble vitamin D 3 | 2.0 | 8.0 | 3.5 | 5.0 | 4.6 | 6.0 |
| Watermiscible vitamin E | 15.0 | 45.0 | 22.0 | 30.0 | 27.0 | 25.0 |
| Menadione sodium bisulfite 3 | 2.5 | 4.5 | 3.0 | 4.0 | 3.6 | 3.0 |
| Cobastab 1 | 2.0 | 5.0 | 3.0 | 4.0 | 3.0 | 3.0 |
| Cobastab 2 | 3.0 | 10.0 | 5.0 | 8.0 | 5.5 | 6.0 |
| Cobastab 6 | 3.0 | 7.0 | 4.5 | 6.5 | 5.0 | 3.5 |
| Cobastab 12 | 4.0 | 8.0 | 5.5 | 7.0 | 7.0 | 7.0 |
| Biotin | 1.0 | 4.0 | 2.0 | 3.0 | 2.6 | 2.5 |
| Folic acid | 1.0 | 5.0 | 2.5 | 4.0 | 3.0 | 3.0 |
| Niacinamide usp | 10.0 | 30.0 | 15.0 | 22.0 | 20.0 | 18.0 |
| Calcium pantothenate | 5.0 | 10.0 | 7.0 | 8.5 | 8.0 | 6.0 |
| Vitamin C | 50.0 | 120.0 | 70.0 | 110.0 | 100.0 | 90.0 |
| Carnitine | 0.15 | 1.2 | 0.4 | 1.0 | 1.0 | 1.0 |
| Beta carotene | 20.0 | 80.0 | 35.0 | 70.0 | 50.0 | 60.0 |
| Lysine | 8.0 | 30.0 | 12.0 | 20.0 | 12.0 | 20.0 |
| Methionine | 4.0 | 10.0 | 6.0 | 9.0 | 7.0 | 8.5 |
| Threonine | 1.0 | 10.0 | 4.0 | 8.0 | 5.0 | 8.5 |
| Tryptophan | 1.0 | 10.0 | 4.0 | 8.0 | 5.0 | 6.5 |
| Arginine | 40.0 | 80.0 | 50.0 | 75.0 | 65.0 | 65.0 |
| FOS | 40.0 | 100.0 | 55.0 | 750.0 | 65.0 | 60.0 |
| Glutamine | 200.0 | 400.0 | 250.0 | 320.0 | 300.0 | 355.45 |
| Lipoic acid | 10.0 | 50.0 | 15.0 | 35.0 | 20.0 | 40.0 |
| DEXTROSE ANHYDROUS | 200.0 | 480.0 | 250.0 | 360.0 | 258.7 | 229.5 |
Implementation result:
(1) application in latter half of gestation and weaning period piglet diet
Choose gestation 10 of the sows of growing up of 104 days (with joining boar and being Du Luoke), by parity, body weight, be divided at random 2 groups, control group fed basal diet, test group in basal diet, add 1g/kg anti-stress bioremediation composition (embodiment 1) experimental period from sow antenatal 10 days (gestation 104 days) to 21 days postpartum, the pig that farrows 21 ages in days wean, the control group piglet basal diet of feeding, test group adds in basal diet that 1g/kg is anti-stress bioremediation composition (embodiment 1), piglet 21 daily ration wean, test to piglet 28 ages in days (latter 1 week of wean) end.
Result of the test, test group and control group piglet 28 age in days litter weights are respectively 57.5kg and 54.0kg, individual weight is respectively 5.61kg and 5.74kg, activity of SOD in serum is respectively 124.91 and 77.35 (U/mgprot), MDA (MDA) is respectively 1.91 and 2.87 (nmol/ml), enteron aisle tryptic activity is respectively 239.74 and 119.71 (U/mgprot), Duodenal villi height is respectively 320.00 and 270.0 (μ m), the duodenal recess degree of depth is 298.0 and 368.0 (μ m), control group enteron aisle fine hair is sparse, peel off serious, test group intestinal villi is compared with large and many, clear in structure, structure is relatively complete.Application is anti-stress bioremediation composition, can alleviate the ablactation stress of piglet, and the intestinal tract injury that wean is caused has good repair.
(2) application of weanling pig
Choose 60 of 28 age in days weanling pigs, according to body weight, sex, be divided at random 2 groups, 30 every group, establish 3 repetitions, 10 of every repetitions, male and female half and half.Control group fed basal diet, test group is added 1g antioxidation biology remediation composition capable (embodiment 3), free choice feeding, drinking-water by every kg in basal diet.Record feed intake, observe body condition variation, test and weigh after 7 days.Result of the test finds, test group feeding piglet is after 7 days, piglet good bloom, and honey stomach, ight soil is to be talked yellowly, is shaped, active, is obviously better than control group, and the indivedual piglets of control group have diarrhoea.The average daily feed intake of control group piglet is 280g, and daily gain is 208g, and test group is 355g and 254g, improves 26% and 22% respectively than control group, and the price of deed also obviously improves.
(3) grow under the hot conditions application of pig
60 of DLY tri-crossbreedings choosing the about 40kg of body weight, are divided into 2 groups at random by body weight, sex, every group of 3 repetitions, 10 of every repetitions, male and female half and half.Control group fed basal diet, test group resists by every kg interpolation 1g in basal diet stress bioremediation composition (embodiment 5).Test 30 days.Test was carried out in southern high-temperature 7-8 in season month, and test pig is up to 39 ℃, 22 ℃ of minimum temperatures, average 32 ℃, medial humidity 68% containing interior room temperature.Feeding in each component hurdle, raises term harmonization, powder dry feeding, and free choice feeding and freely drinking water, other carry out routinely.
Result of the test, the average daily ingestion amount 2.43kg of test group, average daily gain 825g, material anharmonic ratio 2.94; Test group is respectively 2.33kg, 735g and 3.17, and test group daily ingestion amount and daily gain improve 4.0% and 12.0% than control group respectively, and material anharmonic ratio declines 8.0%.Test group group and control group SOD in serum are respectively 94.36 and 89.63 (U/ml), and GSH-Px is respectively 479.50 and 447.48 (μ mol/L), and MDA is respectively 3.02 (nmol/ml) and 3.44 (nmol/ml).Under heated press conditions, the anti-oxidation resistance that stress bioremediation composition can significantly improve pig, improves the production performance of pork pig.
The above, it is only preferred embodiment of the present invention, not the present invention is done to any pro forma restriction, any content that does not depart from technical solution of the present invention, any simple modification, equivalent variations and the modification above embodiment done according to technical spirit of the present invention, all belong to the scope of technical solution of the present invention.
Claims (4)
- One boar with trophism anti-stress with bioremediation composition, it is characterized in that, described composition is comprised of each component of following parts by weight:
- Pig as claimed in claim 1 with trophism anti-stress with bioremediation composition, it is characterized in that, described composition is comprised of each component of following parts by weight:
- Pig as claimed in claim 1 with trophism anti-stress with bioremediation composition, it is characterized in that, described composition is comprised of each component of following parts by weight:
- One kind prepare pig as claimed in claim 1 with trophism anti-stress with the method for bioremediation composition, it is characterized in that, after described method comprises the steps: described each component evenly to mix, get final product end product pig with trophism anti-stress with bioremediation composition.
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| CN104872419A (en) * | 2015-05-15 | 2015-09-02 | 上海交通大学 | Anti-oxidative stress nutritional composition for breeding sows and preparation method of anti-oxidative stress nutritional composition for breeding sows |
| ITUA20162588A1 (en) * | 2016-04-14 | 2017-10-14 | Difass Int S R L | Use of a composition comprising alpha-lipoic acid. |
| CN106138037A (en) * | 2016-08-24 | 2016-11-23 | 江苏农林职业技术学院 | The compositions of a kind of antibiont cell oxidative damage and application thereof |
| CN113519709A (en) * | 2021-06-10 | 2021-10-22 | 上海新邦生物科技有限公司 | Composite health-care immunopotentiator and application thereof |
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| JP2005124536A (en) * | 2003-10-27 | 2005-05-19 | Fumio Dosono | Feed additive for livestock and method for producing the same |
| CN101669587B (en) * | 2009-09-22 | 2011-12-21 | 北京福乐维生物技术有限公司 | Boar nutrition replenisher and preparation method thereof |
| CN102106472B (en) * | 2010-12-07 | 2013-04-24 | 北京龙科方舟生物工程技术有限公司 | Complex additive for boars and preparation method and using method thereof |
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Effective date of registration: 20200103 Address after: 201600 No. 4263, Wenxiang Road, Songjiang District, Shanghai Patentee after: SHANGHAI XINNONG FEED CO., LTD. Address before: 200240 Dongchuan Road, Shanghai, No. 800, No. Patentee before: Shanghai Jiaotong University |
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Address after: 201600 No. 4263, Wenxiang Road, Songjiang District, Shanghai Patentee after: Shanghai Xinnong Technology Co., Ltd Address before: 201600 No. 4263, Wenxiang Road, Songjiang District, Shanghai Patentee before: SHANGHAI XINNONG FEED Co.,Ltd. |