CN101669587B - Boar nutrition replenisher and preparation method thereof - Google Patents
Boar nutrition replenisher and preparation method thereof Download PDFInfo
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- CN101669587B CN101669587B CN2009100926663A CN200910092666A CN101669587B CN 101669587 B CN101669587 B CN 101669587B CN 2009100926663 A CN2009100926663 A CN 2009100926663A CN 200910092666 A CN200910092666 A CN 200910092666A CN 101669587 B CN101669587 B CN 101669587B
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- boar
- vitamin
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- nutritious supplementary
- supplementary pharmaceutical
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Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a boar nutrition replenisher and a preparation method thereof. The boar nutrition replenisher comprises the components based on parts by weight: 30-50 parts of vitamin A, 13-15 parts of vitamin D, 15-25 parts of vitamin E, 0.08-0.12 part of vitamin B12, 8-12 parts of nicotinic acid amide, 4-6 parts of calcium pantothenate, 55-65 parts of vitamin C, 0.08-0.12 part of biotin, 1-11.4 parts of beta-carotene, 1-2 parts of folic acid, 0.08-0.12 part of organic chromium, 8-12 parts of L-carnitine, 20-30 parts of dihydropyridine, 70-90 parts of electrolyte, 500-800 parts of oligosaccharide, 4-6 parts of lysine, 0.8-0.9 part of valine and 5-7 parts of glutamine. The invention can improve the immunity of the organism of breeding stock, conception rate, birth rate, breeding capacity and fertility rate; furthermore, solubilization and periderm are also carried out on the insoluble raw materials, so that the nutrition replenisher can be added into feed and drinking water.
Description
Technical field
The present invention relates to a kind of field of feed processing, particularly relate to a kind of boar nutritious supplementary pharmaceutical and preparation method thereof.
Background technology
Along with the raising of large-scale pig farm intensification degree and the increasing of stocking density, mass-sending property breeder performance has lowly become a great problem of puzzlement pig industry.According to statistics, at present China can surpass 4,000 ten thousand by the brood sow amount of livestock on hand, and at least 8 hundred million of healthy weanling pigs can be provided in theory, but reality only can provide more than 500,000,000, and the loss that the reproductive performance of visible pig lowly brings for China's pig industry is huge.Improve boar breeding achievement and be and realize the valid approach of the highly efficient and productive fundamental sum of pig industry, though present stage, large-scale pig farm all passed through strict seed selection and seed selection, the production performance of boar has obtained certain raising, but every summer, owing to be subjected to the influence of stress factor such as high temperature, high humidity, cause the boar semen qualification rate to descend, sow agalasisa syndrome (MMA) rises, returns feelings and obviously increases, weak young, stillborn foetus rising, grice diarrhoea rises, survival rate descends; Have a strong impact on the economic benefit of large-scale cultivation field, causing bigger economic loss.
Hygrothermal environment is to the influence of breeder performance: 1) the boar sexual desire weakens, and ejaculate volume reduces, and sperm motility reduces; 2) replacement gilt puberty and sexal maturity postpone, and oestrus of sow is postponed, and recessiveness is oestrused and even do not oestrused; 3) ovary function and sexual hypofunction, conception rate significantly descends.4) high temperature reduces the embryo survival digital display work in the 8d of breeding back, secondly plants that (back 11～20d) of being impregnated is responsive especially to heat, and stronger heat resistance is then arranged behind the 20d in several days in that the embryo is attached; 5) the sow gestation phase suffer damp and hot stress, summer, the sow nest litter size and the young number of living can reduce more than 1, the sow lactation amount reduces, the suckling pig undergrowth, weanling weight is little.Boar is after continuing for 2 weeks under 27 ℃ of environment, and sperm motility will descend, and the quantity of abnormal spermium significantly increases.Through after the heat stress, need the time boar of 1 wheat harvesting period could recover normal.Heat stress also can make boar show that sexual desire descends, problem such as drowsiness.If temperature surpasses 29 ℃ in the house, the semen quality of boar all can descend during 4～6 weeks so after this.Because technology of artificial insemination makes the used semen quality of each breeding be guaranteed, so can stablizing, the breeding parturition rate remains on more than 85%, but because sow still can't get rid of by the influence of heat stress, so the sow embryo all produces the young number of living in various degree decline can take place inevitably still.
For a long time, people often improve the reproductive performance of boar by adding sex hormone or medicine, to boar mainly with human chorionic gonadtropin or pregnant mare serum, but the injection hormone causes the boar stress reaction easily and upsets normal physiological function, and can not fundamentally solve kind of pig breeding dysfunction and semen quality, can not solve the boar nutritional deficiency that causes owing to all stress factor, and cause the degeneration of boar breeding function easily.Patent 20061001 improves herd boar sperm quality and sow conception rate by a series of drug regimens, dominant mechanism is by regulating the function of Leptin, promote breeding stock reproduction physiogeny, but this medicine can not fundamentally change physique, reduce the influence of external environment breeder performance.Vitamin stability is poor in the high temperature season feed, and particularly fat-soluble A, E inefficacy when environment temperature surpasses 30 ℃ is faster, and these vitamins are to keep the most most important vitamin of normal breeding activity.The B family vitamin is as the coenzyme of three big metabolism on the other hand, and heat stress causes that organism metabolism strengthens, and has increased the demand of B family vitamin.Suitably add vitamin, amino acid, electrolyte etc. and can fundamentally regulate the boar physiological metabolism, reduction stress improve reproductive performance to the harmful effect of kind of pig body.
The Another reason that breeder performance reduces is the propagated cell energy shortage.Oestrous cycle of sow can be ovulated 18-24, but really can be fertilized and develop into having only about the 10-14 head of little pig, main cause be do not run into suitable sperm (the in good time or unqualified sperm of breed) after ovum is discharged, do not run into the enough sperms of energy (problem of boar), embryonated egg energy (sperm, ovum in conjunction with time energy not enough) inadequately, embryonated egg can not implantation; Embryonated egg behind the implantation does not have enough energy, and implantation power is poor, can not finely obtain nutrition, bad, the easy miscarriage of development of fetus from parent (uterine wall).Chromium can promote glucose metabolism as the bioactive molecule of the tolerance factor of glucose, reduces the energy shortage of sperm and ovum.L-cn can improve the metabolism of aliphatic acid as lipometabolic coenzyme, improves the energy of sperm and ovum.
The Another reason that breeder performance reduces is that boar nutrition is unbalanced, and digestibility is low, immunity degradation, thus cause the body production performance to descend, reproductive capacity goes down.Use antibiotic can improve boar enteron aisle structure, improve immunity, but medicament residue is the difficult point of puzzlement animal husbandry always.Calendar year 2001, the Europe expert found that freezing of Chinese exports contains the chloramphenicol of 0.2ppb to 5ppb in the shrimp, and this makes China's aquatic products industry outlet seriously baffle, so the research of antibiotic substitute is in the ascendant.Functional oligosaccharide can well be improved livestock and poultry alimentary tract physiology as the antibiotic substitute of green, keeps the gut flora balance, becomes the research focus.Patent 01136594 is improved the animal alimentary canal flora by a series of oligosaccharides combinations, but does not consider the nutrient balance of breeding stock, not from the basic immunity of strengthening collective.
Summary of the invention
The purpose of this invention is to provide a kind of nutritious supplementary pharmaceutical,, thereby solve the problems referred to above that prior art exists with additional pig feed subalimentation and raising swine reproduction performance.
The invention provides a kind of boar nutritious supplementary pharmaceutical, it comprises following active ingredient by weight: vitamin A 30-50 part, vitamin D 13-15 part, vitamin E 15-25 part, cobalamin 0.08-0.12 part, niacinamide 8-12 part, calcium pantothenate 4-6 part, vitamin C 55-65 part, biotin 0.08-0.12 part, beta carotene 1-11.4 part, folic acid 1-2 part, Organic Chromium 0.08-0.12 part, l-cn 8-12 part, dihydropyridine 20-30 part, lysine 4-6 part, electrolyte 70-90 part, compound sugar 500-800 part, lysine 4-6 part, valine 0.8-0.9 part, glutamine 5-7 part.
Preferably, it comprises following active ingredient by weight: vitamin A 40-45 part, vitamin D 14-15 part, vitamin E 20-23 part, cobalamin 0.08-0.12 part, niacinamide 8-12 part, calcium pantothenate 4-6 part, vitamin C 60-62 part, biotin 0.08-0.12 part, beta carotene 1-3 part, folic acid 1-2 part, Organic Chromium 0.08-0.12 part, l-cn 8-9 part, dihydropyridine 20-30 part, lysine 4-5 part, electrolyte 70-72 part, compound sugar 700-730 part, lysine 4-5 part, valine 0.8-0.9 part, glutamine 5-7 part.
Boar nutritious supplementary pharmaceutical of the present invention also comprises the additive of following weight parts: solubilizer 20-50 part, cyclodextrin saturated solution 100-300 part and antioxidant 0.5-20 part.
Described solubilizer is Tween 80.
Described antioxidant is tert-butyl-5-methyl phenol and uncle's propyl group-tetrahydroxy anisole mixture, and weight ratio is 1: 1-3.
Wherein, described Organic Chromium is a chromium picolinate.
Described electrolyte is the mixture of potassium chloride, sodium chloride, sodium acid carbonate and ammonium chloride, and the weight ratio of four kinds of components is 1-10: 2-10: 2-10: 2-50.
Described compound sugar is the mixture of manna oligosacchride, chitosan oligosaccharide and isomalto-oligosaccharide, and the weight ratio of three kinds of components is 1-3: 1-2: 2-50.
The present invention also provides the method for the above-mentioned boar nutritious supplementary pharmaceutical of preparation, comprises the steps:
1) fat-soluble A, D, E are carried out solubilising and handle, mix with B12, niacinamide, biotin, calcium pantothenate then;
2) beta carotene, dihydropyridine, l-cn are made soluble powder;
3) product and the remaining ingredient with step 1, step 2 mixed 20～25 minutes, promptly.
Wherein, step 1) is that fat-soluble A, D, E and antioxidant are mixed with solubilizer, carries out solubilising and handles, and mixes with B12, niacinamide, biotin, calcium pantothenate then.
Step 2) concrete steps are beta carotene, dihydropyridine, l-cn to be joined in the acetone soln dissolve, under agitation gradually the cyclodextrin saturated solution is joined in the acetone soln, be mixed and pour in the tissue mashing machine after even, high-speed mixing was handled 6-15 minute under 4000-8000 changes, handled equally again 3-9 minute after stopping, boil off acetone and a part of water afterwards, put refrigerator overnight, after leaching product and cleaning, make soluble powder after the drying with ethanol; Described drying can be dried in vacuum drying chamber, or uses the spray drying process drying.
General breeding nutrition product has limited the interpolation of these products because many raw materials are water insoluble, and particularly drinking-water uses.The present invention handles insoluble raw material in process of production, and some insoluble raw materials have been carried out the bag quilt, makes this product dissolubility in water splendid, has expanded the use approach of breeding nutriment, has improved the result of use of animal health product.
The present invention further provides the using method of described nutritious supplementary pharmaceutical, comprise the steps:
A: milking sow: the omnidistance interpolation: 500 gram/ton mixed feeds, drinking-water :/1000 liters of 500 grams; Preceding 2 thoughtful the oestrusing between the breeding season of weaning: 1000 gram/ton mixed feeds, drinking-water :/1000 liters of 1000 grams;
B: replacement gilt, in-pig: spice: 500 gram/ton mixed feeds drinking-water :/1000 liters of 500 grams;
C: herd boar: spice: 1000 gram/ton mixed feeds drinking-water :/1000 liters of 500 grams.
Wherein, folic acid influences the synthetic of embryo's growth, particularly protein, DNA and RNA, the shortage of folic acid is synthesizing of restricted dna not only, and can cause the synthetic of defective dna, thus causing death and fetal anomaly, gestation needs leafier acid to keep the quick differentiation of embryonic cell in early days.Effect is more obvious when adding folic acid in the sow daily ration litter size and the number of live pig survival just being had that folate content is low in the remarkable effect, particularly feed.
Chromium can improve sow reproductive performance, significantly improves reproductive capacity, adds organochromium compounds in the daily ration of pig, can improve the litter size of sow.The achievement in research of Lindemann etc. (1994) shows that organochromium compounds can obviously improve the litter size of first farrowing sow.Large result shows that the application of Organic Chromium has improved numerous indexs of livestock and poultry reproductive performances, and reproductive capacity significantly improves.
Beta carotene is a kind of very effective free radical scavenger, the damage that can protect higher ovarian follicle (corpus luteum) of activity and uterine cell to avoid free radical.Secondly, beta carotene mainly is present in the corpus luteum, forms the indispensable component of lutein cell and plays an important role in breeding, and the short spilting of an egg of beta carotene acts on ovulation and reaches maximum mid-term, recovers normal in the ovulation later stage.Chew, Brief and Chew research think that beta carotene can guarantee embryo survival, may be owing to secreted more uterus specific protein.Beta carotene may be as a kind of antioxidant; protection uterus, ovary steroids cellulation are avoided oxidative damage; may regulate the activity of target cell nuclear, beta carotene can make pig lutein cell progesterone secretion amount improve 10 times, than big many of the effect of retinol or retinoic acid.
Dihydropyridine is a kind of novel multifunctional additive with some effect of natural VE, can suppress the peroxidating process of lipoid substance, changes some hormonal readiness in the serum, promotes livestock and poultry reproductive performance and immunologic function; Dihydropyridine can guarantee the meticulous after birth of herd boar and the integrality of morphosis, improves the acrosomal integrity of sperm, reduces abnormal rate, and can promote the breathing of sperm, improves the intake of 32Pi.Dihydropyridine also can improve follicle-stimulating hormone (FSH) and the metakentrin of sow.
In the lactating sow daily ration, supply with sufficient lysine, can reduce the sow body weight and descend, improve piglet survival rate and litter weight.Because 1st, 2 tire sow appetite are relatively poor, but also are in growth and development stage, this moment, sow daily ration lysine content was answered 1.2-1.3%, and each parity is 0.95% later on.In addition, valine content is usually not enough in the lactating sow daily ration, and the valine in the daily ration should reach 1: 1.28 with the ratio of lysine.
(Glutamine is a kind of profuse amino acid in mammalian plasma and the sow milk Gln) to glutamine, is a kind of important nutrient.Studies show that in recent years, stress with pathological conditions under, endogenous Gln often can not satisfy the animal body needs, even the Gln exhaustion takes place.Replenish glutamine to boar and can improve the reproductive performance of boar, improve piglet survival ratio.
The l-cn most important function is to promote fatty acid oxidation, promotes the production of aliphatic acid, for sperm and ovum provide enough energy.On the other hand, carnitine can also improve the utilization rate of forage protein, improves animal immunizing power.Carnitine can also promote the absorption of liposoluble vitamin, promotes the maturation of sperm.
Manna oligosacchride can stimulate the immune response of body, can combine with some toxin, virus, fungal cell surface, reduces the absorption of antigen, strengthens the cell and the humoral immunity of body.
Chitosan oligosaccharide is the animality affairs fiber of the unique positively charged example of occurring in nature.Its effect is: (1) improves the livestock and poultry alimentary tract flora, and profitable strains such as propagation Bifidobacterium, lactic acid bacteria improve Abwehrkraft des Koepers.(2) absorption enteric pathogenic bacteria, chitosan oligosaccharide can emulatively combine with pathogen cell surface lectin, stops pathogen to adhere to enterocyte.(3) noxious materials such as chitosan oligosaccharide absorption heavy metal, radioactive element, pigment stimulate intestines peristalsis, reduce the time of staying of intestinal contents.
Isomalto-oligosaccharide can be preferably the Bifidobacterium utilization and directly enter large intestine not by absorptions such as amylase, invertases.Isomalto-oligosaccharide can combine with inspiration, has reduced the propagation of harmful intestinal tract bacteria.The opposing party, isomalto-oligosaccharide can also improve the concentration of immunoglobulin (Ig) in animal intestinal and the serum and the number of bone-marrow-derived lymphocyte, increases the release and the interferon activity of cell factor, whole humoral immunity and the cellular immune function that improves breeding stock.
Boar nutritious supplementary pharmaceutical of the present invention has following beneficial effect:
1, boar nutritious supplementary pharmaceutical of the present invention can replenish boar special physiological period and various stress situation under needed multivitamin, amino acid, effectively prevent and treat vitamin-deficiency.
2, promote that dam oestruses, number of eggs ovulated, raising conception rate and farrowing rate; Prevent the sow cracked feet, reduce mortality.Improve milking capacity, reduce the generation of mammitis and agalactia syndrome.Promote piglet survival ratio.
3, improve boar breeding capacity and rate of fertilization, keep good semen quality, prolong service life.
4, the interpolation of Organic Chromium can improve endocrine, reduce the influence that stress wait factor that boar is caused, and improves the litter size of sow, reduces rate of teratosperm, improves sperm and ovum energy.
5, beta carotene is a kind of physiological antioxidant; can protect sow uterus and ovary sterid synthetic cell to avoid the harm of oxidant effect; keep normally carrying out of ovulation, implantation and gestation; improve litter size; correct sow quiet estrus and delayed ovulation, improve survival rate of embryo.Add beta carotene in the boar feed and can promote testicualr development, improve semen quality.
6 carriers of the present invention are the combination of manna oligosacchride, chitosan oligosaccharide, three kinds of functional oligosaccharide of isomalto-oligosaccharide, can improve the immune resistance of boar, and antibiotic-free is residual.The present invention provides matrix to beneficial bacterium, and intestinal microflora has been set up in the field planting of the inhibition of wide spectrum and interference pernicious bacteria, has promoted the secretion of endogenous digestive ferment, improves intestines and stomach physiology.
The specific embodiment
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
Among the embodiment raw material components be all commercial.
Embodiment 1
Boar nutritious supplementary pharmaceutical of the present invention comprises following component: vitamin A 40g, VD1 4g, vitamin E 20g, cobalamin 0.10g, niacinamide 10g, calcium pantothenate 5g, vitamin C 60g, biotin 0.1g, beta carotene 1.2g, folic acid 1.5g, chromium picolinate 0.1g, l-cn 10g, dihydropyridine 25g, lysine 6g, electrolyte 70g, compound sugar 600g, valine 0.8g, glutamine 5g, tert-butyl-5-methyl phenol 6g, uncle's propyl group-tetrahydroxy anisole 6g, Tween 80 30g, cyclodextrin saturated solution 150g; Comprise potassium chloride 5g, sodium chloride 10g, sodium acid carbonate 10g and ammonium chloride 45g in the electrolyte; Comprise manna oligosacchride 100g, chitosan oligosaccharide 200g and isomalto-oligosaccharide 300g in the compound sugar.
Follow these steps to preparation:
1) with 40gVA, 14gVD, 20gVE, tert-butyl-5-methyl phenol 1g, uncle's propyl group-tetrahydroxy anisole 1g, the 30g Tween 80 mixes, and carries out solubilising and handles.Get cobalamin 0.10g then, niacinamide 10g, calcium pantothenate 5g, biotin 0.1g, folic acid 1.5g, isomalto-oligosaccharide 100g carries out elementary mixing.
2) get beta carotene 1.2g, l-cn 10g, dihydropyridine 25g joins solution in the 100ml acetone, configuration 150g cyclodextrin saturated solution; In beaker, pour the cyclodextrin saturated solution into, under agitation add this product acetone soln gradually, mixing, pour in the tissue mashing machine, high-speed mixing was handled 15 minutes under 6000 commentaries on classics, handled equally 8 minutes after stopping again, boil off acetone and water afterwards, in refrigerator overnight, leach and clean the back with small amount of ethanol behind the product and in vacuum drying chamber, dry, or use the spray drying process drying.
3) with step 1, step 2 and chromium picolinate 0.1g, potassium chloride 5g, sodium chloride 10g, sodium acid carbonate 10g, ammonium chloride 45g, vitamin C 60g, manna oligosacchride 100g, chitosan oligosaccharide 200g, isomalto-oligosaccharide 200g, valine 0.8g, glutamine 5g, lysine 6g, tert-butyl-5-methyl phenol 5g, uncle's propyl group-tetrahydroxy anisole 5g, silica 2g, mineral white oil 15g evenly is mixed and made into the 1000g finished product.
Embodiment 2
Boar nutritious supplementary pharmaceutical of the present invention comprises following component: vitamin A 45g, VD1 5g, vitamin E 23g, cobalamin 0.12g, niacinamide 12 value g, calcium pantothenate 6g, vitamin C 62g, biotin 0.12g, beta carotene 2g, folic acid 2g, chromium picolinate 0.12g, l-cn 10g, dihydropyridine 30g, lysine 6g, valine 0.9g, glutamine 7g, tert-butyl-5-methyl phenol 5 grams, uncle's propyl group-tetrahydroxy anisole 6.5 grams, Tween 80 32 grams, cyclodextrin saturated solution 170g; Wherein, comprise potassium chloride 5 grams, sodium chloride 10 grams, sodium acid carbonate 10 grams and ammonium chloride 45 grams in the electrolyte; Comprise manna oligosacchride 100 grams, chitosan oligosaccharide 220 grams, isomalto-oligosaccharide 330 grams in the compound sugar.
Follow these steps to preparation:
1) with 45gVA, 15gVD, 23gVE, tert-butyl-5-methyl phenol 1g, uncle's propyl group-tetrahydroxy anisole 1.5g, the 32g Tween 80 mixes, and carries out solubilising and handles.Get cobalamin 0.12g then, niacinamide 12g, calcium pantothenate 6g, biotin 0.12g, folic acid 2g, isomalto-oligosaccharide 120g carries out elementary mixing.
2) get beta carotene 2g, l-cn 10g, dihydropyridine 30g join in the 110ml acetone soln, configuration 170g cyclodextrin saturated solution.In beaker, pour the cyclodextrin saturated solution into, under agitation add this product acetone soln gradually, mixing, pour in the tissue mashing machine, high-speed mixing was handled 6 minutes under 6000 commentaries on classics, handled equally 3 minutes after stopping again, boil off acetone and water afterwards, in refrigerator overnight, leach and clean the back with small amount of ethanol behind the product and in vacuum drying chamber, dry, or use the spray drying process drying.
3) with step 1, step 2 and chromium picolinate 0.12g, vitamin C 62g, potassium chloride 5 grams, sodium chloride 10 grams, sodium acid carbonate 10 grams, ammonium chloride 45 grams, vitamin C 60 grams, manna oligosacchride 100 grams, chitosan oligosaccharide 220 grams, isomalto-oligosaccharide 210 grams, valine 0.9g, glutamine 7g, tert-butyl-5-methyl phenol 4 grams, uncle's propyl group-tetrahydroxy anisole 5.5 grams, silica 2g, mineral white oil 15g evenly is mixed and made into the 1000g finished product.
Embodiment 3
Boar nutritious supplementary pharmaceutical of the present invention comprises following component: vitamin A 42g, VD1 4g, vitamin E 22g, cobalamin 0.08g, niacinamide 8g, calcium pantothenate 4g, vitamin C 61g, biotin 0.08g, beta carotene 1g, folic acid 1g, chromium picolinate 0.08g, l-cn 8g, dihydropyridine 20g, lysine 4g, tert-butyl-5-methyl phenol 6g, uncle's propyl group-tetrahydroxy anisole 6g, Tween 80 30g, cyclodextrin saturated solution 150g; Wherein, comprise potassium chloride 10g, sodium chloride 10g, sodium acid carbonate 10g and ammonium chloride 40g in the electrolyte; Comprise manna oligosacchride 150g, chitosan oligosaccharide 250g and isomalto-oligosaccharide 320g in the compound sugar, valine 0.8g, glutamine 5g.
Follow these steps to preparation:
1) with 42 gram VA, 14 gram VD, 22 gram VE, tert-butyl-5-methyl phenol 1 gram, uncle's propyl group-tetrahydroxy anisole 1 gram, 30 gram Tween 80s mix, and carry out solubilising and handle.Get cobalamin 0.08g then, niacinamide 8g, calcium pantothenate 4g, biotin 0.08g, folic acid 1g, isomalto-oligosaccharide 90g carries out elementary mixing.
2) get beta carotene 1g, l-cn 8g, dihydropyridine 20g joins in the 90ml acetone soln, configuration 150g cyclodextrin saturated solution, in beaker, pour the cyclodextrin saturated solution into, under agitation add this product acetone soln gradually, mixing, pour in the tissue mashing machine, high-speed mixing was handled 6～15 minutes under 6000 commentaries on classics, handled equally 3～9 minutes after stopping again, boil off acetone and water afterwards, in refrigerator overnight, leach and clean the back with small amount of ethanol behind the product and in vacuum drying chamber, dry, or use the spray drying process drying.
3) with step 1, step 2 and chromium picolinate 0.12g, vitamin C 61g, potassium chloride 5 grams, sodium chloride 15 grams, sodium acid carbonate 15 grams, ammonium chloride 35 grams, manna oligosacchride 150 grams, chitosan oligosaccharide 250 grams, isomalto-oligosaccharide 230 grams, valine 0.8g, glutamine 5g, tert-butyl-5-methyl phenol 5 grams, uncle's propyl group-tetrahydroxy anisole 5 grams, silica 2 grams, mineral white oil 15 grams evenly are mixed and made into the 1000g finished product.
Experimental example 1
Materials and methods
1.1 experimental design
The design of single-factor contrast test is adopted in this test, if 6 processed group, promptly test 1 group, 2 groups of tests, 3 groups of tests, 4 groups of tests, test 5 groups and test 6 groups, preceding 5 test group are the boar nutritious supplementary pharmaceutical that adds 100g, 200g, 300g, 400g and the 500g embodiment of the invention 1 per ton on the basal diet basis respectively, the 6th group of interpolation 500g embodiment of the invention 3 per ton on basal diet.
1.2 experimental animal
The test swinery is a condition with the less boar of age in days, body weight, health status and hereditary difference, select the test boar of 60 90 ages in days for use, be divided into 6 groups at random, every group 10, feeding successively, it is strong to add varying level good fortune power in the basic diet, each processed group test pig divides two circles to raise 5 on every circle.
1.3 test daily ration
The test daily ration is consulted to formulate by Beijing Fuwish Biotechnology Co., Ltd and plant jointly.
1.4 feeding and management
Test pig is raised in semi-open, semiclosed pig house.The special messenger raises, the personal management, and day feeds 2 times.Before the experiment test pig is carried out routine immunization and the processing of expelling parasite regularly.Regularly, quantitative feeding each organize corresponding diet, supply with sufficient drinking-water.Maintenance colony house drying is used alternatingly compound phenol weekly for twice and hundred poisonings are carried out routine disinfection to colony house.
1.5 semen collection and processing
Test 120d rises and adopts the semen collection of free-hand semen collection method, and every 3d adopts 1 time, and semen collection is 4 times altogether.Place 10～18 ℃ to preserve down the seminal fluid of the test boar adopted, carry out main routine index of semen then and measure (need in 72h, measure).
1.6 test determination project
Ejaculate volume, sperm concentration, defective sperm ratio, the mensuration such as sperm ratio, sperm motility rate of living.
1.7 data are handled
Data statistics adopts the ANOVA program among the SAS8.2 to carry out statistical analysis, uses Duncan ' s method to carry out multiple ratio.The result represents with " average ± standard deviation ".2 results and analysis
The influence of table 1 pair quality of boar semen
| The mensuration project | Test 1 group | Test 2 groups | Test 3 groups | Test 4 groups | Test 5 groups | Test 5 groups |
| Ejaculate volume/mL | 122.80±2. 54 | 131.33±3 .07 | 133.63±2 .68 | 132.78± 4.33 | 139.56±3. 15 | 136.43±2. 05 |
| Sperm concentration/% | 133.50±24 .2 | 136.30±2 6.4 | 140.00±3 1.7 | 154.20± 38.4 | 160.10±25 .80 | 157.46±23 .22 |
| Defective sperm ratio/% | 9.08±1.55 | 8.97±2.4 4 | 8.58±3.3 0 | 8.42±1.9 3 | 8.36±2.88 | 8.39±2.62 |
| Sperm ratio/% lives | 68.50±7.3 5 | 69.13±5. 63 | 69.38±4. 51 | 71.15±4. 70 | 76.08±5.5 7 | 74.53±5.4 5 |
| Sperm motility rate/% | 58.64±7.9 6 | 58.82±6. 03 | 59.57±4. 76 | 64.31±6. 10 | 66.36±7.6 6 | 64.98±8.0 1 |
As can be seen from Table 1, increase along with the addition of boar nutritious supplementary pharmaceutical of the present invention in daily ration, ejaculate volume, sperm concentration, live sperm ratio and also increase thereupon of sperm motility rate, ejaculate volume is tested 5 groups than 1 group high by 13.65% of test, tests 6 groups than 1 group high by 11.09% of test.Sperm concentration is tested 5 groups than 1 group high by 19.93% of test, tests 6 groups than 1 group high by 17.94% of test.The sperm ratio of living is tested 5 groups than 1 group high by 11.07% of test, tests 6 groups than 1 group high by 8.80% of test.Sperm motility rate is tested 5 groups than 1 group high by 13.17% of test, tests 6 groups than 1 group high by 10.81% of test.。With the increase of boar nutritious supplementary pharmaceutical addition of the present invention, the defective sperm ratio descends, and tests 5 groups than 1 group low 7.93% of test, tests 6 groups than 1 group low 7.60% of test.
The research that experimental example 2 boar nutritious supplementary pharmaceuticals of the present invention are used in brood sow produces
1 materials and methods
1.1 experimental animal, basal diet and feeding and management
1.1.1 experimental animal and feeding and management
Choose 40 of health, age, nonpregnant sows (the weanling sow of piglet) that body condition is close, be divided into 2 groups at random: control group and test group.The totally enclosed type pig house, roof ventilating fan ventilates, and the house temperature remains on 20～26 ℃.Freely drink water in the whole test phase, restriction is fed, and divides every day early, supplies with for late 2 times, and experimental period is the production cycle of sow, and feed consumption rate calculates according to 450kg.
1.1.2 common negotiation of basal diet Beijing Fuwish Biotechnology Co., Ltd and plant determined.
1.2 experimental design
Select 40 of the close nonpregnant sows of health, age, body condition for use, be equally divided into 2 groups at random, control group and test group.The control group daily ration is a basal diet, the boar nutritious supplementary pharmaceutical of test group interpolation 500g embodiment of the invention 2 per ton on the basal diet basis.
1.3 testing index
The equal litter size of record nest, nest young number all alive, live young counterpoise, weak young rate, number of weaned are observed sow and piglet growth health condition at sows in lactation simultaneously.
Diarrhea rate.
1.4 data statistics and processing
Test all data and use the t check to carry out significance of difference analysis, data are represented with mean+SD.
2 results and analysis
2.1 influence to sow production performance
The influence of table 2 pair sow production performance
| Project | Control group | Test group |
| Nest litter size (head) | 9.30±1.8 | 10.20±2.0 |
| Nascent counterpoise (kg) | 1.38±0.34 | 1.45±0.51 |
| Wean counterpoise (kg) | 6.23±1.52 | 7.12±2.34 |
| Childbirth survival rate (%) | 84.50±3.87 | 92.37±4.52 |
| Weak young rate (%) | 11.23±6.73 | 2.98±2.56 |
| Number of weaned (%) | 78.21±4.86 | 96.19±5.93 |
| Oestrus of sow is fate (d) at interval | 4.58±1.07 | 3.42±0.75 |
| Suckling pig diarrhea rate (%) | 3.62±0.12 | 1.98±0.17 |
As can be seen from Table 1, the nest litter size of test group, nascent counterpoise and the equal weight average that weans are higher than control group, and the nest litter size is high by 9.68%, and nascent counterpoise improves 5.07%, and the wean counterpoise improves 14.29%.Childbirth survival rate test group is higher than control group 9.31%, and weak young rate test group is lower by 73.46% than control group, and the number of weaned test group is higher by 22.99% than control group.Oestrus of sow fate test group at interval shortens 25.33% than control group.Illustrate that this product can improve the production performance of brood sow.While as can be seen, adds the happy strong plain suckling pig diarrhea rate of organizing and significantly is lower than not interpolation group in table 1, and test group is than control group low 45.30%.
Be rich in abundant folic acid, biotin and vitamin C in the boar nutritious supplementary pharmaceutical of the present invention, three kinds of vitamins are most important to brood sow.Folic acid is the synthetic RNA and the requisite cooperation factor of DNA, the shortage of folic acid is synthesizing of restricted dna not only, and in purine and pyrimidine building-up process, because uracil replaces thymidine, and then cause the synthetic defective that occurs of DNA, if contain the DNA of this defective, will cause death and fetal anomaly in the embryonic development stage.The addition that increases folic acid can improve the nest litter size, may be that Leption has important function to the control breeding because folic acid participates in reconciling the Leption acceptor and endometrium is rented.The stage that biotin works is the fetal growth phase, the embryo is behind the uterine wall implantation, the growth of fetus mainly depends on the kind and the level of the filtration selection nutriment of placenta, thereby for fetal growth obtains required nutrition, and can increase surface area of placenta later stage of pregnancy after replenishing biotin, provide better nutrition thereby help fetus.Discover that additional biotin can also make the length of sow cornua uteri increase by 20%, and then increased fetus and in the uterus, take up space that this growth and survival to fetus has great importance.And vitamin C has participated in the synthetic of cortex hormone of aadrenaline, and cortex hormone of aadrenaline stress play key effect for reducing.Breast milk is that piglet obtains ascorbic unique source before the age in week.Proved also in this test that boar nutritious supplementary pharmaceutical of the present invention has played important function aspect grice diarrhoea.
3 add the Economic and Efficiency Analysis behind the present invention
The feed cost that the back increases after the boar nutritious supplementary pharmaceutical of an interior use of production cycle of the sow embodiment of the invention 2: 450kg*0.5kg/1000kg*35 unit/kg=7.875 unit.
The income that improve to increase because of piglet survival ratio: 9.3 newborn piglet/nest * (92.37-84.50) %*270 unit/weanling pig=197.62 yuan/nest; Improve the income that increases because of wean: (7.12-6.23) 9.3/nest of 18 yuan of/* of kg/ *=148.99 yuan/nest.
Economic benefit: sow feed adds happy strong plain and income is increased at least: (197.62+148.99) unit/nest-7.875 yuan/nest=338.735 yuan/nest.Sow shortens the feed cost that can save because of inter oestrual period: 2.3 yuan/kg=7.75 of 450kg/155 days * (4.58-3.42) * unit.For a pig farm that 500 sows are arranged, year economic benefit is increased: 500 * 2.3 nest * (338.735 yuan/nest+7.75 yuan /)=39.85 ten thousand yuan/year, can economic benefit very considerable because of using happy strong element.
4 conclusions
The animal health product that the present invention uses as a kind of brood sow are used for Sow Diet, can effectively improve birth weight and the weaning weight of piglet, reduce diarrhea rate, improve a year economic benefit.
Claims (6)
1. a boar nutritious supplementary pharmaceutical is characterized in that, comprises following active ingredient by weight: 3-Hydroxyretinol 0-50 part, vitamin D 13-15 part, vitamin E 15-25 part, cobalamin 0.08-0.12 part, niacinamide 8-12 part, calcium pantothenate 4-6 part, vitamin C 55-65 part, biotin 0.08-0.12 part, beta carotene 1-11.4 part, folic acid 1-2 part, Organic Chromium 0.08-0.12 part, l-cn 8-12 part, dihydropyridine 20-30 part, lysine 4-6 part, electrolyte 70-90 part, compound sugar 500-800 part, lysine 4-6 part, valine 0.8-0.9 part, glutamine 5-7 part;
Wherein, described electrolyte is the mixture of potassium chloride, sodium chloride, sodium acid carbonate and ammonium chloride, and the weight ratio of four kinds of components is 1-10: 2-10: 2-10: 2-50; Described compound sugar is the mixture of manna oligosacchride, chitosan oligosaccharide and isomalto-oligosaccharide, and the weight ratio of three kinds of components is 1-3: 1-2: 2-50;
The preparation method of described boar nutritious supplementary pharmaceutical comprises the steps:
1) fat-soluble A, D, E are carried out solubilising and handle, mix with B12, niacinamide, biotin, calcium pantothenate then;
2) beta carotene, dihydropyridine, l-cn are made soluble powder;
3) product and the remaining ingredient with step 1, step 2 mixed 20～25 minutes, promptly.
2. boar nutritious supplementary pharmaceutical according to claim 1 is characterized in that, comprises following active ingredient by weight: vitamin A 40-45 part, vitamin D 14-15 part, vitamin E 20-23 part, cobalamin 0.08-0.12 part, niacinamide 8-12 part, calcium pantothenate 4-6 part, vitamin C 60-62 part, biotin 0.08-0.12 part, beta carotene 1-3 part, folic acid 1-2 part, Organic Chromium 0.08-0.12 part, l-cn 8-9 part, dihydropyridine 20-30 part, lysine 4-5 part, electrolyte 70-72 part, compound sugar 700-730 part, lysine 4-5 part, valine 0.8-0.9 part, glutamine 5-7 part.
3. boar nutritious supplementary pharmaceutical according to claim 1, it is characterized in that, the additive that also comprises following weight parts: solubilizer 20-50 part, cyclodextrin saturated solution 100-300 part, antioxidant 0.5-20 part, silica 1-10 part and mineral white oil 10-50 part.
4. boar nutritious supplementary pharmaceutical according to claim 3 is characterized in that, described solubilizer is Tween 80.
5. boar nutritious supplementary pharmaceutical according to claim 1 and 2 is characterized in that, described Organic Chromium is a chromium picolinate.
6. a method for preparing each described boar nutritious supplementary pharmaceutical of claim 1-5 is characterized in that, comprises the steps:
1) fat-soluble A, D, E are carried out solubilising and handle, mix with B12, niacinamide, biotin, calcium pantothenate then;
2) beta carotene, dihydropyridine, l-cn are made soluble powder;
3) product and the remaining ingredient with step 1, step 2 mixed 20～25 minutes, promptly.
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| CN102370077A (en) * | 2010-08-08 | 2012-03-14 | 嘉善百世威生物技术有限公司 | Special feed additive premix for sow and application method thereof |
| CN102028121B (en) * | 2010-12-15 | 2012-07-11 | 上海申亚动物保健品有限公司 | Additive premix feed for pigs and preparation method thereof |
| CN102178110B (en) * | 2011-05-12 | 2012-10-17 | 比利美英伟营养饲料（深圳）有限公司 | Premix feed for improving reproductive performance of boar |
| CN102204645B (en) * | 2011-06-22 | 2013-03-20 | 武汉回盛生物科技有限公司 | Compound premixed feed for breeding pigs and preparation method thereof |
| CN102335138A (en) * | 2011-08-09 | 2012-02-01 | 北京福乐维生物技术有限公司 | Preparation method of nano-composite vitamin with anti-stimulation action and livestock universality |
| CN102934744A (en) * | 2012-07-03 | 2013-02-20 | 山东绿都安特动物药业有限公司 | Regulating agent capable of resisting stress, promoting growth and improving metabolism for pigs |
| CN103005204B (en) * | 2012-12-18 | 2014-04-30 | 上海交通大学 | Nutritional anti-stress bioremediation composition for pigs and preparation method thereof |
| CN103493993A (en) * | 2013-08-26 | 2014-01-08 | 镇江天和生物技术有限公司 | Water-soluble feed premix for preventing and treating fattening pig heat stress |
| CN104431340B (en) * | 2013-09-13 | 2017-12-26 | 中国科学院大连化学物理研究所 | A kind of function saccharide complex for improving wean jenny follicular development ability and its application |
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