CN104431340B - A kind of function saccharide complex for improving wean jenny follicular development ability and its application - Google Patents
A kind of function saccharide complex for improving wean jenny follicular development ability and its application Download PDFInfo
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- CN104431340B CN104431340B CN201310418475.8A CN201310418475A CN104431340B CN 104431340 B CN104431340 B CN 104431340B CN 201310418475 A CN201310418475 A CN 201310418475A CN 104431340 B CN104431340 B CN 104431340B
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Abstract
The invention discloses a kind of function saccharide complex for improving wean jenny follicular development ability.Contain following component in the every 1kg feeds of compound of the present invention:1~500mg of chitosan oligosaccharide, 1~500mg of FOS, 1~500mg of zymosan.The present invention is a kind of function saccharide complex for improving wean animal follicular development ability, with immunocompetence, resistance against diseases and the follicular development ability for improving animal, this compound is had no toxic side effect, noresidue, addition are few, pollution-free, reproducible, and environment is had no adverse effect.
Description
Technical field
A kind of function saccharide complex for the jenny follicular development ability that weans the present invention relates to raising, more specifically,
It is a kind of animal functional sugar feed addictive containing oligosaccharides, polysaccharide, belongs to agro-ecology product technique field.
Background technology
In animal productiong（Such as pig, ox, sheep）, often there are the weary feelings of animal.Weary feelings are in mainly due to animal ovary
Relative static conditions, follicular development can not be promoted ripe for the gonadotrophin secretion level in hypophysis and ovulation.General use promotees
Gonadal hormone, gonadotropin-releasing hormone (GRH)（GnRH）And the like stimulating animal follicular development and ovulate, make Anestrus sows
Heat, breed and become pregnant.But in actual animal productiong, some dams being still difficult to ovulate using its ovarian follicle after hormonal action or
Number of eggs ovulated is still less, even results in sow per tire litter size only 2-3 heads.Therefore, improved from actual production angle in sow ovary
Follicular development ability turns into the important measures for improving sow reproductive performance, and to improving the economic benefit of sow with very careless
Justice.
In addition, functional sugar content in feed addictive is atomic, but the physiological action that it is played in animal body is very big, tool
There is promotion beneficial to bacteria growing, suppress harmful intestinal tract bacteria growing, while it has reducing blood lipid, anti-oxidant, regulation is immune, promotes to absorb
Etc. multinomial physiological function, intestinal health can be adjusted, aggregate level improves the general level of the health of animal.
The major function of functional sugar：
Chitosan oligosaccharide：Improve animal immunizing power；Improve wean pig growth performance；Anticancer；Adjust blood fat；Adjust animal intestinal tract bacterium
Group.
FOS：Strengthen effect with bifidus factor；Balance intestinal microbial environment, promote intestinal bifidobacteria and lactic acid
Bacillus grows；Have the function that to relax bowel.
Zymosan：Reduce the harm of aflatoxins, zearalenone in feed；With mitigating radiation injury, disease-resistant
Poison, excite and promote the physiological actions such as immunologic function.
This research is that theoretical base is established in application of the functional oligosaccharide feed addictive in China's high efficiency animal, fine quality production
Plinth, more objective theoretical foundation is provided as the application of feed addictive using for chitosan oligosaccharide, be China's animal husbandry to it is intensive,
Scale and green direction, which are developed, provides effective theoretical foundation.
The content of the invention
It is an object of the present invention to provide one kind is nutritious, content is sufficient, it is possible to increase wean jenny follicular development energy
The function saccharide complex of power.
To achieve the above object, the technical solution adopted by the present invention is：
The present invention is a kind of function saccharide complex for improving wean animal follicular development ability, is contained in its every 1kg feed
Following component：1~500mg of 1~500mg of chitosan oligosaccharide, 1~500mg of FOS and zymosan.
The chitosan oligosaccharide degree of polymerization is between 2~8, and deacetylation is more than 95%, and molecular weight is between 300~2000Da.
The FOS degree of polymerization is between 2~10, and mean molecule quantity is between 300~2000Da.
The zymosan is yeast cell wall extract.
The complex components include：Chitosan oligosaccharide：10~200 parts by weight, FOS：10~200 parts by weight, yeast are more
Sugar：10~200 parts by weight.
The function saccharide complex can add as the feed for improving wean jenny follicular development ability active ingredient
Add agent.
Addition of the function saccharide complex in every kilogram of feed be：
Chitosan oligosaccharide：1~500mg, FOS：1~500mg, zymosan：1~500mg.
The function saccharide complex is applied to jenny, and continuously feeds female in weaning period, the gestational period and nursing period
Animal.
The function saccharide complex needs to be added in the perfect compound feed of jenny.This function saccharide complex exists
Need to mix with perfect compound feed according to the ratio before use, or be fabricated to feed addictive use.
The present invention is needed in weaning period, the gestational period and nursing period Long-term Feeding jenny, and Long-term Feeding is to reach
Optimum efficiency.
Advantages of the present invention has：Three kinds of functional sugars are used in combination, and can improve the nest litter size and ovarian follicle of animal well
Developmental potency.It is the simple to operate, efficiency high of the present invention, pollution-free, reproducible, suitable for large-scale production.
Brief description of the drawings
Fig. 1 functional sugars are to the mouse ovarian follicular development capacity that weans；
Note：aControl group ovary（40×）, follicular development is to the antral follicles stage in ovary；bControl group ovary（100×）,
Follicular development is to the antral follicles stage in ovary；cChitosan oligosaccharide group ovary（40×）, follicular development is to graaffian follicle rank in ovary
Section, a small number of ovarian follicles have occurred and that ovulation；dChitosan oligosaccharide group ovary（100×）, follicular development is few to the graaffian follicle stage in ovary
Number ovarian follicle has occurred and that ovulation；eFunctional sugar complex group ovary（40×）, follicular development is a small number of to the graaffian follicle stage in ovary
Ovarian follicle has occurred and that ovulation；fFunctional sugar complex group ovary（100×）, follicular development is to graaffian follicle stage, a small number of ovum in ovary
Bubble has occurred and that ovulation.
Embodiment
Zymosan used in the present invention refers to Hou Ranran（2007）The process for extracting of use.With beer waste yeast
Mud is raw material, and under the conditions of different temperatures, different time, different PH, glucomannans is extracted using citrate buffer solution method,
The Thick many candies of extraction are used into Fehling reagent simultaneously, Cetyltrimethyl Ammonium Bromide method and Sevage methods are carried out at de- albumen
Reason.
The present invention is further illustrated below in conjunction with embodiment.
Case study on implementation 1：Functional sugar influences on mouse litter size
（1）Experimental animal：Female KM mouse, cleaning grade animal, 3~4 week old, 12 ± 3g are real by Dalian Medical Univ
Animal center offer, approval number SCXK are provided（The Liao Dynasty）2008-0002, the raising of cleaning grade Animal House, 20 ± 1 DEG C of temperature, humidity 40%
~50%, illumination 12h, pellet are fed, free water.Feed the daily ration of mouse containing functional sugar more than 6 weeks, mouse weight is reachable
To 26 ± 3g, available for mating test.
（2）Experimental method：Mouse is randomly divided into 3 groups（Blank control group, chitosan oligosaccharide group, functional sugar complex group）, first
Group is blank control group, perfect compound feed of the feeding without functional sugar（It is shown in Table 1）；Second group is chitosan oligosaccharide group, and feeding contains
The perfect compound feed of 300mg/kg chitosan oligosaccharides；3rd group is functional sugar complex group, feeding chitosan oligosaccharide containing 100mg/kg, 100mg/
The perfect compound feed of kg FOSs, 100mg/kg zymosans.Meanwhile full price of the male mice feeding without functional sugar coordinates
Feed.The perfect compound feed of the saccharide complex containing function is fed more than 6 weeks, until mouse reaches sexual maturing period.Select energy prosperous
The female mice of Sheng and male mouse, according to female：Male=1:1 is mated, and is continued untill mouse is become pregnant and is farrowed.
（3）Detection project：Litter size.
（4）Statistical method：The data collected are divided using SPSS Duncan's multiple range test
Analysis.
（5）Experimental result：
Can be seen that functional sugar complex group and chitosan oligosaccharide group from the result of table 2. can significantly improve the litter size 13.40 of mouse
± 3.00/13.50 ± 1.83/11.33 ± 3.11, functional sugar complex group/chitosan oligosaccharide group/control group) (P<0.05).
The experimental basis daily ration of table 1. forms and nutritional ingredient
The functional sugar of table 2. influences on the first parity of mouse litter size
Case study on implementation 2：Functional sugar is to the female mice follicular development capacity that weans
（1）Experimental animal：Mouse source used in the experiment of this group is identical with upper group of experiment.Female and male in embodiment 1
After mouse mates and farrows and terminate, continue to feed feed containing functional sugar to mouse, mouse weight reaches 51.2 ± 0.4g.Mouse exists
Cleaning grade Animal House is raised, 20 ± 1 DEG C of temperature, humidity 40%~50%, illumination 12h, and pellet is fed, free water.
（2）Experimental method：Selection build is similar, and the active female mice of energy is randomly divided into 3 groups.Mouse is randomly divided into 3 groups
（Blank control group, chitosan oligosaccharide group, functional sugar complex group）.First group is blank control group, and full price of the feeding without functional sugar is matched somebody with somebody
Close feed；Second group is chitosan oligosaccharide group, feeds the perfect compound feed of the chitosan oligosaccharide containing 300mg/kg；3rd group is that functional sugar is compound
Group, feed chitosan oligosaccharide containing 100mg/kg, 100mg/kg FOSs, the perfect compound feed of 100mg/kg zymosans.It is meanwhile male
Property mouse feeding without functional sugar perfect compound feed.Feed the perfect compound feed of the saccharide complex containing function more than 6 weeks, directly
Reach sexual maturing period to mouse.Female mice vigorous and male mouse are selected, according to female：Male=1:1 is mated, until small
Mouse farrows after becoming pregnant.Newborn mouse is developed to weaning period, random selection wean female mice, disconnected neck is put to death and obtains liver, spleen, kidney,
Ovary, uterus are simultaneously weighed, and are recorded and are counted shoot formation.Meanwhile the shape of follicular development in ovary is observed using HE staining techniques
State feature.
（3）Detection project：The shoot formation such as ovary and uterus, ovarian follicle morphology.
（4）Statistical method：The data collected are divided using SPSS Duncan's multiple range test
Analysis.
（5）Experimental result：
Can be seen that functional sugar complex group from the result of table 3. can significantly improve wean Mouse Uterus index（0.09±0.02/
0.05 ± 0.02, functional sugar complex group/control group, P<0.05）, and ovarian index can not be improved（0.03±0.01/0.03±
0.01, functional sugar complex group/control group, P>0.05）.
The functional sugar of table 3. is to the mouse organs' exponential effect that weans
From Fig. 1, in chitosan oligosaccharide group and functional sugar complex group ovary, ovarian follicle has been developed to the graaffian follicle stage, and
And a small number of ovarian follicles have been ovulated.And in control group ovary tissue, only observe antral follicles.
Claims (4)
- A kind of 1. application for the function saccharide complex for improving wean jenny follicular development ability, it is characterised in that：The work( Can active ingredient of the saccharide complex as the feed addictive for improving wean jenny follicular development ability；The functional sugar is answered Addition of the compound in every kilogram of feed be：Chitosan oligosaccharide：100 ~ 500mg, FOS：100 ~ 500mg, zymosan：100~500mg.
- 2. according to the application described in claim 1, it is characterised in that：The chitosan oligosaccharide degree of polymerization is between 2 ~ 8, and deacetylation is more than 95%, and molecular weight is between 300 ~ 2000Da；The fruit The oligosaccharides degree of polymerization is between 2 ~ 10, and mean molecule quantity is between 300 ~ 2000Da；The zymosan is yeast cell wall extract.
- 3. according to the application described in claim 1, it is characterised in that：The function saccharide complex is applied to jenny, and Weaning period, the gestational period and nursing period continuously feed.
- 4. according to the application described in claim 1, it is characterised in that：The function saccharide complex needs to be added to jenny In perfect compound feed.
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| CN1370575A (en) * | 2002-01-09 | 2002-09-25 | 张勇飞 | Composite prepn for preventing and treating young animal's darrhea and its prepn process |
| CN1615727A (en) * | 2003-11-13 | 2005-05-18 | 中国科学院微生物研究所 | Oligose fodder additive and its producing method |
| CN101669587A (en) * | 2009-09-22 | 2010-03-17 | 北京福乐维生物技术有限公司 | Boar nutrition replenisher and preparation method thereof |
| CN102178112A (en) * | 2011-05-12 | 2011-09-14 | 比利美英伟营养饲料（深圳）有限公司 | Premix feed for relieving astriction of sows |
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