CN102335138A - Preparation method of nano-composite vitamin with anti-stimulation action and livestock universality - Google Patents
Preparation method of nano-composite vitamin with anti-stimulation action and livestock universality Download PDFInfo
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- CN102335138A CN102335138A CN201110226804XA CN201110226804A CN102335138A CN 102335138 A CN102335138 A CN 102335138A CN 201110226804X A CN201110226804X A CN 201110226804XA CN 201110226804 A CN201110226804 A CN 201110226804A CN 102335138 A CN102335138 A CN 102335138A
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Abstract
The invention relates to a preparation method of nano-composite vitamin with anti-stimulation action and livestock universality. The method comprises the following steps: 1, dissolving vitamin A and vitamin E into peanut oil in which an anti-oxidant is added in advance, and adding a proper amount of surfactant and distilled water in which the anti-oxidant and a metal ion complexing agent are added to obtain a uniform and transparent solution; 2, dissolving sodium benzoate in the distilled water, gradually adding vitamin B1, vitamin B2, sodium phosphate, vitamin B6 and vitamin C, stirring for dissolving, gradually adding folic acid, nicotinamide and calcium pantothenate, respectively adding glycine, methionine, lysine, glutamic acid and threonine, uniformly stirring, finally adding glucose, mannanoligosaccharides and astragalus polysaccharides, and dissolving to obtain a transparent uniform solution; and 3, slowly adding the solution prepared in the step 2 into a solution system prepared in the step 1, uniformly stirring, and fixing volume by use of the distilled water in which the anti-oxidant and the metal ion complexing agent are added to obtain a transparent and stable nano-composite system.
Description
Technical field
The present invention relates to the method for preparing of nano combined vitamin, specifically, is a kind of method for preparing with the general nano combined vitamin of anti-stress effect fowl poultry.
Background technology
Vitamin is humans and animals nutrition, necessary some a small amount of organic compound of growth, and metabolism, growth, growth, the health of body is played an important role.If certain vitamin of long-term lacking will cause the physiological function obstacle and certain disease takes place.Vitamin can not synthesize in body, can not fully store again.Be divided into two types of fatsoluble vitamin and water soluble vitamins.The former comprises vitamin A, vitamin D, vitamin E, vitamin K etc., and the latter has vitamin B group, vitamin C, folic acid etc.Can not normal growth when humans and animals is deficient in vitamin, and specific lesions, promptly so-called avitaminosis take place.Generally by obtaining in the food.
Aminoacid is the common name that contains one type of organic compound of amino and carboxyl.The basic composition unit of biological function macro-molecular protein is the base substance that constitutes the Animal nutrition desired protein.Glucose has critical role in field of biology, is the energy source of living cells.Astragalus polysaccharides be the dry root of the Radix Astragali through the dried powder that concentration extraction forms, can be used as immunopotentiating agent or regulator, have effects such as antiviral, antitumor, defying age, radioprotective, anti-stress, antioxidation simultaneously.Mannooligo saccharide can improve adaptive capacity, the anti-stress ability of poultry to environment, can reduce enteric pathogenic bacteria, promotes the probiotics breeding, regulates the little ecosystem balance of livestock and poultry alimentary tract, improves function of intestinal canal.
At present in breeding production, the raiser uses electrolysis multidimensional the most generally.Electrolysis multidimensional soluble components, and add n-butyl alcohol as stabilizing agent, dilute standardize solution with water for injection, prepared a kind of compound vitamin nano-emulsion, the nano-emulsion of preparation only contains 4 kinds of fat-soluble vitamin, does not contain water miscible vitamin.The vitamin kind that above-mentioned disclosed two kinds of nano-emulsion systems contain is few, and adopts water for injection as the dissolving water, has increased cost.Adopt the solvent of benzyl alcohol, lack the adding of antioxidant,, increased the unstability of system because vitamin is prone to degraded as fatsoluble vitamin.Aspect growth of animal, can not satisfy the needs of body fully.
The present invention has invented a kind of method for preparing with the general nano combined vitamin of anti-stress effect fowl poultry.The present invention adopts easily the Oleum Arachidis hypogaeae semen that is absorbed by body as fat-soluble solvent; As surfactant, fat-soluble A and vitamin E are added dissolving, with surfactant polyoxyethylene sorbitan mono-oleic acid ester and castor oil hydrogenated and ethylene oxide condensate in order to prevent decomposition of vitamin; In system, added tertiarybutylhydroquinone as antioxidant; At first prepared transparent oil-phase solution, adopted the distillation water as solvent then, used distilled water has added sodium sulfite in advance as antioxidant; Disodiumedetate is the complexing of metal ion agent, and purpose also is in order to prevent the degraded of water soluble vitamins.Earlier sodium benzoate is dissolved in the distilled water then; By adding vitamin B1, vitamin B2 sodium phosphate, vitamin B6, vitamin C, folic acid, nicotiamide and calcium pantothenate in proper order; Add glycine, methionine, lysine, glutamic acid, threonine, astragalus polysaccharides, mannooligo saccharide and glucose after the stirring and dissolving, stirring becomes transparent aqueous phase solution system.The aqueous phase solution system is slowly joined in the oil-phase solution body, with the distilled water standardize solution that has added sodium sulfite and disodiumedetate, obtain transparent nano-emulsion system at last,, meet the steady-state conditions of study on the stability through study on the stability.Contain 9 kinds of vitamin, 5 seed amino acids in this nanometer system, contain glucose, mannooligo saccharide and astragalus polysaccharides simultaneously.This compound vitamin nano-emulsion has anti-stress effect, is fit to vitimin supplement and amino acid whose needs.It is a kind of general nano combined vitamin system of anti-stress effect fowl poultry that has.
Summary of the invention
The purpose of this invention is to provide a kind of method for preparing with the general nano combined vitamin of anti-stress effect fowl poultry.This method for preparing technology is simple, low cost of manufacture, has the good commercial prospect.
In order to achieve the above object, the present invention adopts following technical scheme:
This method for preparing is carried out in two steps.The first step at first is dissolved in fatsoluble vitamin in the Oleum Arachidis hypogaeae semen; Added a certain amount of antioxidant in the Oleum Arachidis hypogaeae semen in advance; Mix; Add the surfactant and the distilled water of Sq, added antioxidant and complexing of metal ion agent in this distilled water in advance, obtain the solution of homogeneous transparent.
Second step was earlier sodium benzoate to be dissolved in the distilled water; Water soluble vitamins joins stirring and dissolving in the distilled water gradually; Adding glycine, methionine, lysine, glutamic acid and threonine then respectively stirs; Add glucose, mannooligo saccharide and astragalus polysaccharides stirring and dissolving at last, obtain transparent uniform solution.
The solution of second step preparation is slowly joined in the solution system of first step preparation, stir, with the distilled water standardize solution that has added antioxidant and complexing of metal ion agent in advance, obtain transparent system at last.This system is through using instrument detecting, and granularity is in 30 nanometers, and through study on the stability, system is the stabilized nano compound system.Containing 9 kinds of vitamin, 5 seed amino acids in this nanometer system, contain glucose, mannooligo saccharide and astragalus polysaccharides simultaneously, is a kind of general nano combined vitamin system of anti-stress effect fowl poultry that has.
Described fatsoluble vitamin is vitamin A and vitamin E.Rice, through study on the stability, system is the stabilized nano compound system.Contain 9 kinds of vitamin, 5 seed amino acids in this nanometer system, contain glucose, mannooligo saccharide and astragalus polysaccharides simultaneously.This compound vitamin nano-emulsion has anti-stress effect, is suitable for fowl poultry vitimin supplement and amino acid whose needs.It is a kind of general nano combined vitamin of anti-stress effect fowl poultry that has.
More than a kind of method for preparing with the general nano combined vitamin of anti-stress effect fowl poultry provided by the present invention has been carried out detailed introduction; Used concrete example among this paper principle of the present invention and embodiment are set forth, the explanation of above embodiment just is used for helping to understand method of the present invention and core concept thereof; Simultaneously, for one of ordinary skill in the art, according to thought of the present invention, the part that on the specific embodiment and range of application, all can change, in sum, this description should not be construed as limitation of the present invention.
Claims (7)
1. the method for preparing with the general nano combined vitamin of anti-stress effect poultry is characterized in that, comprises following steps:
This method for preparing is carried out in two steps.The first step at first is dissolved in fatsoluble vitamin in the Oleum Arachidis hypogaeae semen; Added a certain amount of antioxidant in the Oleum Arachidis hypogaeae semen in advance; Mix; Add the surfactant and the distilled water of Sq, added antioxidant and complexing of metal ion agent in this distilled water in advance, obtain the solution of homogeneous transparent.
Second step was earlier sodium benzoate to be dissolved in the distilled water; Water soluble vitamins is joined stirring and dissolving in the distilled water gradually; Adding glycine, methionine, lysine, glutamic acid and threonine then respectively stirs; Add glucose, mannooligo saccharide and astragalus polysaccharides stirring and dissolving at last, obtain transparent uniform solution.
The solution of second step preparation is slowly joined in the solution system of first step preparation, stir, with the distilled water standardize solution that has added antioxidant and complexing of metal ion agent in advance, obtain transparent system at last.This system is through using instrument detecting, and granularity is in 30 nanometers, and through study on the stability, system is the stabilized nano compound system.Containing 9 kinds of vitamin, 5 seed amino acids in this nanometer system, contain glucose, mannooligo saccharide and astragalus polysaccharides simultaneously, is a kind of general nano combined vitamin system of anti-stress effect fowl poultry that has.
2. the method for preparing of the nano combined vitamin that the poultry with anti-stress effect as claimed in claim 1 are general is characterized in that fatsoluble vitamin is vitamin A and vitamin E.
3. the method for preparing of the nano combined vitamin that the poultry with anti-stress effect as claimed in claim 1 are general is characterized in that a certain amount of antioxidant is tertiarybutylhydroquinone.
4. the method for preparing of the nano combined vitamin that the poultry with anti-stress effect as claimed in claim 1 are general; It is characterized in that surfactant is the complexed surfactant of polyoxyethylenesorbitan sorbitan monooleate and castor oil hydrogenated and ethylene oxide condensate composition.
5. the method for preparing of the nano combined vitamin that the poultry with anti-stress effect anti-stress effect as claimed in claim 1 are general is characterized in that antioxidant is sodium sulfite, and the complexing of metal ion agent is a disodiumedetate.
6. the method for preparing of the nano combined vitamin that the poultry with anti-stress effect as claimed in claim 1 are general; It is characterized in that water soluble vitamins is made up of B1, vitamin B2 sodium phosphate, vitamin B6, vitamin C, folic acid, nicotiamide and calcium pantothenate.
7. the method for preparing of the general nano combined vitamin of the poultry of anti-stress effect as claimed in claim 1 is characterized in that, comprises following steps:
The first step at first is dissolved in fatsoluble vitamin in the Oleum Arachidis hypogaeae semen; Added a certain amount of tertiarybutylhydroquinone in the Oleum Arachidis hypogaeae semen in advance; Mix; Add the polyoxyethylenesorbitan sorbitan monooleate of Sq and the complexed surfactant and the distilled water of castor oil hydrogenated and ethylene oxide condensate composition, added sodium sulfite and disodiumedetate in this distilled water in advance, obtain the solution of homogeneous transparent.
Second step was that water-soluble (vitamin) B 1, B2 sodium phosphate, vitamin B6, vitamin C, folic acid, nicotiamide and calcium pantothenate are joined stirring and dissolving in the distilled water gradually; Adding glycine, methionine, lysine, glutamic acid and threonine then respectively stirs; Add glucose, mannooligo saccharide and astragalus polysaccharides stirring and dissolving at last, obtain transparent uniform solution.
The solution of second step preparation is slowly joined in the solution system of first step preparation, stir, with the distilled water standardize solution that has added antioxidant and complexing of metal ion agent in advance, obtain transparent system at last.This system is through using instrument detecting, and granularity is in 30 nanometers, and through study on the stability, system is the stabilized nano compound system.Containing 9 kinds of vitamin, 5 seed amino acids in this nanometer system, contain glucose, mannooligo saccharide and astragalus polysaccharides simultaneously, is a kind of general nano combined vitamin system of anti-stress effect fowl poultry that has.
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103549145A (en) * | 2013-10-31 | 2014-02-05 | 北京福乐维生物科技股份有限公司 | Nano nutritional supplement for breeding promotion and stress resistance of breeding poultry and preparation method thereof |
CN103549184A (en) * | 2013-10-31 | 2014-02-05 | 北京福乐维生物科技股份有限公司 | Nano nutritious supplementary with function of fattening pigs and preparation method thereof |
CN103652369A (en) * | 2013-12-04 | 2014-03-26 | 北京福乐维生物科技股份有限公司 | General-purpose livestock nano nutritional agent having anti-stress function and preparation method of the nutritional agent |
CN105078933A (en) * | 2015-07-16 | 2015-11-25 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Application of tert-butylhydroquinone in treating or preventing nerve cell oxidative stress injury |
CN106804485A (en) * | 2017-03-21 | 2017-06-09 | 中国水产科学研究院淡水渔业研究中心 | A kind of method that knife long-tailed anchovy small size pond temporarily supports resisting stress |
CN108208523A (en) * | 2017-12-30 | 2018-06-29 | 天津赫莱恩特生物科技有限公司 | A kind of application of antioxidant composition in liquid vitamin preparation |
CN109566896A (en) * | 2017-09-29 | 2019-04-05 | 北京福乐维生物科技股份有限公司 | One kind having anti-stress effect poultry general nano nutritional agents and preparation method thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101669587A (en) * | 2009-09-22 | 2010-03-17 | 北京福乐维生物技术有限公司 | Boar nutrition replenisher and preparation method thereof |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN101669587A (en) * | 2009-09-22 | 2010-03-17 | 北京福乐维生物技术有限公司 | Boar nutrition replenisher and preparation method thereof |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103549145A (en) * | 2013-10-31 | 2014-02-05 | 北京福乐维生物科技股份有限公司 | Nano nutritional supplement for breeding promotion and stress resistance of breeding poultry and preparation method thereof |
CN103549184A (en) * | 2013-10-31 | 2014-02-05 | 北京福乐维生物科技股份有限公司 | Nano nutritious supplementary with function of fattening pigs and preparation method thereof |
CN103652369A (en) * | 2013-12-04 | 2014-03-26 | 北京福乐维生物科技股份有限公司 | General-purpose livestock nano nutritional agent having anti-stress function and preparation method of the nutritional agent |
CN105078933A (en) * | 2015-07-16 | 2015-11-25 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Application of tert-butylhydroquinone in treating or preventing nerve cell oxidative stress injury |
CN106804485A (en) * | 2017-03-21 | 2017-06-09 | 中国水产科学研究院淡水渔业研究中心 | A kind of method that knife long-tailed anchovy small size pond temporarily supports resisting stress |
CN106804485B (en) * | 2017-03-21 | 2019-12-17 | 中国水产科学研究院淡水渔业研究中心 | Stress-resistant method for temporarily culturing coilia ectenes in small water body |
CN109566896A (en) * | 2017-09-29 | 2019-04-05 | 北京福乐维生物科技股份有限公司 | One kind having anti-stress effect poultry general nano nutritional agents and preparation method thereof |
CN108208523A (en) * | 2017-12-30 | 2018-06-29 | 天津赫莱恩特生物科技有限公司 | A kind of application of antioxidant composition in liquid vitamin preparation |
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Application publication date: 20120201 |