CN110892944A - Weaned pig feed additive capable of replacing antibiotics and application thereof - Google Patents

Weaned pig feed additive capable of replacing antibiotics and application thereof Download PDF

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CN110892944A
CN110892944A CN201911296180.1A CN201911296180A CN110892944A CN 110892944 A CN110892944 A CN 110892944A CN 201911296180 A CN201911296180 A CN 201911296180A CN 110892944 A CN110892944 A CN 110892944A
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唐科
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Anhui Mashang Communication Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
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    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
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    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
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    • Y02P60/87—Re-use of by-products of food processing for fodder production

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Abstract

The invention provides a weaned pig feed additive capable of replacing antibiotics and application thereof, and relates to the technical field of feed additives, wherein the feed additive is prepared from plant extracts, a solid microecological preparation, a solid organic acid and a carrier in a mass ratio of 1: 0.5-0.8: 0.4-0.6: 2.8-3.5; the plant extract comprises the following components in parts by weight: 3.2-4 parts of blackberry seed extract, 1.8-2.5 parts of vine tea extract and 0.5-0.8 part of tea saponin; the solid microecological preparation comprises the following components in parts by weight: 3.3-4.2 parts of lactobacillus powder, 0.9-1.5 parts of bacillus licheniformis powder, 1.6-2.3 parts of bacillus natto powder and 2.8-3.6 parts of saccharomyces cerevisiae powder. The substances in the invention have synergistic effect, so that the product is more effective and stable, and can be used in weaned pig feeding instead of antibiotics, thereby effectively improving the organism immunity of the weaned pig, reducing the diarrhea rate, improving the feed conversion rate and the growth performance of the piglet and achieving the effect of quick fattening.

Description

Weaned pig feed additive capable of replacing antibiotics and application thereof
Technical Field
The invention relates to the technical field of feed additives, in particular to a weaned pig feed additive capable of replacing antibiotics and application thereof.
Background
The widespread use of antibiotics in swine production has been in the past 50 years. A plurality of researches show that the antibiotic has good effects on improving the growth efficiency and the feed utilization rate of pigs, reducing the occurrence of diseases and the like. However, as the health requirements of people are gradually increased, the problems of antibiotic residues and microbial resistance in pork are more and more concerned, and the use of antibiotics is strictly limited. The european union has banned the addition of antibiotics to feed in 2006, and the us food and drug administration has phased out the use of non-medical antibiotics in livestock from 2013. Under the background, research for seeking antibiotic substitutes has become a research hotspot in the whole feed and breeding industries. In recent 20 years, antibiotic substitutes in pig production have mainly focused on enzyme preparations, organic acids, probiotics, plant extracts, mineral elements, glutamine, epidermal growth factors, cholate, egg yolk antibodies and the like.
The plant extract is a natural plant product which is obtained by taking plants as raw materials through a series of extraction, separation and purification processes, contains a plurality of active ingredients such as rich alkaloid, saponin, polysaccharide, polyphenol, volatile oil and the like, has the functions of improving the body defense and resistance capacity and relieving stress, enables animals to better regulate physiological functions of all aspects in a relatively severe environment, and greatly improves the adaptability. In addition, the plant extract has the advantages of no residue, no pollution, no public nuisance, easy absorption and the like, and can completely or periodically replace antibiotics to be applied to livestock and poultry breeding.
The Chinese patent with the application number of 201410230973.4 provides a drug feed additive for promoting the growth of weaned pigs and improving the immune function, and the raw material drugs of the drug feed additive comprise campanumaea pilosula, gordon euryale seed, garlic, hawthorn, acanthopanax, dogwood, eight-treasure tea, siegesbeckia orientalis, rose mallow, yarrow, tabasheer, aster ageratoides, mantis egg-case, fructus broussonetiae, rhizoma dioscoreae septemlobae, dendrobium, fingered citron, American ginseng, cubeb, radix curcumae, sea buckthorn, scutellaria baicalensis, coriolus versicolor, tall oil sesame, saururus chinensis and parasitic scutellaria. Compared with antibiotics, hormones and chemically synthesized medicines, the feed additive can prevent medicine residues in piglets, is most of traditional Chinese medicines and has numerous important side effects, and various traditional Chinese medicines need to be prepared during preparation, so that the feed additive is relatively complex. Meanwhile, the feed additive has less improvement on the feed-weight ratio, thereby limiting the economic benefit of farmers.
At present, the research and product development of taking plant extracts as feed additives are on a lower level on the whole, and the 'safety, effectiveness, controllability and stability' are still the core problems to be solved by the modern research. The plant extract is used together with organic acid, probiotics, enzyme preparation and the like, so that the plant extract has better capabilities of promoting growth, improving body immunity and the like for weaned pigs, and has important research significance.
Disclosure of Invention
The invention aims to provide a weaned pig feed additive capable of replacing antibiotics and application thereof, wherein plant extracts, solid microecologics and solid organic acids are reasonable in proportion, and the substances are synergistic, so that the product is more effective and stable, and the feed additive can replace the antibiotics to be used in weaned pig feeding, effectively improve the organism immunity of the weaned pigs, reduce the diarrhea rate, improve the feed conversion rate and the growth performance of the piglets, achieve the effect of fast fattening and further bring more economic benefits for farmers.
In order to achieve the purpose, the invention is realized by the following technical scheme:
the feed additive for weaned pigs, which can replace antibiotics, comprises plant extracts, solid microecologics, solid organic acids and a carrier according to the mass ratio of 1: 0.5-0.8: 0.4-0.6: 2.8-3.5;
the plant extract comprises the following components in parts by weight: 3.2-4 parts of blackberry seed extract, 1.8-2.5 parts of vine tea extract and 0.5-0.8 part of tea saponin;
the solid microecological preparation comprises the following components in parts by weight: 3.3-4.2 parts of lactobacillus powder, 0.9-1.5 parts of bacillus licheniformis powder, 1.6-2.3 parts of bacillus natto powder and 2.8-3.6 parts of saccharomyces cerevisiae powder.
In the invention, the blackberry seed extract and the vine tea extract are obtained by supercritical carbon dioxide extraction;
when the blackberry seed extract is prepared, the technological parameters of supercritical carbon dioxide extraction are as follows: the extraction pressure is 27-30MPa, the extraction time is 2-2.5h, and the extraction temperature is 60-65 ℃;
when preparing the vine tea extract, the technological parameters of supercritical carbon dioxide extraction are as follows: the extraction pressure is 20-24MPa, the extraction time is 1.5-2h, and the extraction temperature is 50-55 ℃.
Preferably, the carrier is prepared by mixing an organic carrier and an inorganic carrier according to the mass ratio of 1: 0.2-0.8, wherein the organic carrier is at least one of α -cyclodextrin, β -cyclodextrin, defatted rice bran and corn flour, and the inorganic carrier is at least one of zeolite powder and vermiculite powder.
Preferably, the solid organic acid is citric acid or tartaric acid.
Preferably, the viable count of the lactobacillus powder is 1-3 multiplied by 1010CFU/g; the viable count of the bacillus subtilis powder is 3-5 multiplied by 108CFU/g; the viable count of the bacillus natto powder is 1-3 multiplied by 109CFU/g; the viable count of the beer yeast powder is 4-7 × 109CFU/g。
Preferably, the lactobacillus powder is at least one of lactobacillus acidophilus, lactobacillus cellobiosus and lactobacillus bulgaricus.
Preferably, the additive is prepared from a plant extract, a solid microecological preparation, a solid organic acid and a carrier according to a mass ratio of 1: 0.6: 0.5: 3.2, the preparation.
Preferably, the preparation method of the feed additive comprises the following steps: respectively crushing the plant extract, the solid microecological preparation, the solid organic acid and the carrier, sieving by a 100-mesh sieve, and uniformly mixing the sieved powder of the plant extract, the solid microecological preparation, the solid organic acid and the carrier according to the mass ratio.
The weaned pig feed additive capable of replacing antibiotics is applied as an antibiotic substitute in weaned pig feeding. When the feed additive is used specifically, the feed additive capable of replacing antibiotics for weaned pigs is added into basic feed for feeding weaned pigs according to the mass fraction of 0.1-0.25%.
The invention has the beneficial effects that:
the blackberry seeds are byproducts of primary processed products such as fruit wine, fruit juice and the like, the blackberry seed extract contains a large amount of procyanidine, and the procyanidine has certain antioxidation and anti-inflammation effects, can prevent and treat diseases of piglets to a certain extent, and can effectively improve the immunocompetence of the piglets. The procyanidine can effectively excite intestines and stomach, promote secretion of digestive gland enzyme, and promote synthesis of hemoglobin and serum low protein, thereby improving utilization rate of feed, effectively promoting growth of piglets, and improving fattening effect. The ampelopsis grossedentata extract contains a large amount of ampelopsis grossedentata flavonoids, so that the immunity of the bodies of piglets can be effectively improved, the fattening effect can be improved, and meanwhile, the ampelopsis grossedentata extract can inhibit bacteria, sterilize and resist inflammation, and has a good effect of reducing the diarrhea rate of animals. The added tea saponin can enhance the digestion and absorption performance of piglets on grease, can enhance the feeding effect, and simultaneously has better antibacterial and antiviral effects.
On the basis of adding the plant extracts, the solid microecological preparation is added, so that the gastrointestinal digestive system can be better improved, the diarrhea rate is effectively reduced, and the feed conversion rate and the production performance are improved. The proper amount of solid organic acid is used for resisting bacteria, acidifying intestinal tracts, promoting digestion and maintaining intestinal tract health. The plant extract, the solid microecological preparation and the solid organic acid are reasonable in proportion, and the substances are synergistic, so that the product is more effective and stable, and can be used in weaned pig feeding instead of antibiotics, the organism immunity of the weaned pig is effectively improved, the diarrhea rate is reduced, the feed conversion rate and the growth performance of the piglet are improved, and the effect of quick fattening is achieved, thereby bringing more economic benefits to farmers.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
a preparation method of a weaned pig feed additive capable of replacing antibiotics comprises the following steps: respectively crushing the plant extract, the solid microecological preparation, the citric acid and the carrier, sieving by a 100-mesh sieve, and then mixing the sieved powder of the plant extract, the solid microecological preparation, the citric acid and the carrier according to a ratio of 1: 0.6: 0.5: 3.2, and mixing uniformly.
Wherein the carrier is prepared by mixing β -cyclodextrin and zeolite powder according to the mass ratio of 1: 0.5.
The plant extract comprises the following components in parts by weight: 3.5 parts of blackberry seed extract, 2.1 parts of vine tea extract and 0.7 part of tea saponin.
The blackberry seed extract and the vine tea extract are obtained by supercritical carbon dioxide extraction; when the blackberry seed extract is prepared, the technological parameters of supercritical carbon dioxide extraction are as follows: the extraction pressure is 28MPa, the extraction time is 2.2h, and the extraction temperature is 60 ℃; when preparing the vine tea extract, the technological parameters of supercritical carbon dioxide extraction are as follows: the extraction pressure is 20MPa, the extraction time is 2h, and the extraction temperature is 53 ℃.
The solid microecological preparation comprises the following components in parts by weight: 3.5 parts of lactobacillus acidophilus powder, 1 part of bacillus licheniformis powder, 2 parts of bacillus natto powder and 3 parts of beer yeast powder.
The number of viable bacteria of Lactobacillus acidophilus powder is 1.5 × 1010CFU/g; the viable count of the bacillus subtilis powder is 4 multiplied by 108CFU/g; the viable count of the bacillus natto powder is 2.2 multiplied by 109CFU/g; the viable count of the beer yeast powder is 6 multiplied by 109CFU/g。
Example 2:
a preparation method of a weaned pig feed additive capable of replacing antibiotics comprises the following steps: respectively crushing the plant extract, the solid microecological preparation, the citric acid and the carrier, sieving by a 100-mesh sieve, and then mixing the sieved powder of the plant extract, the solid microecological preparation, the citric acid and the carrier according to a ratio of 1: 0.5: 0.5: 3, the mixture is uniformly mixed.
Wherein, the carrier is prepared by mixing β -cyclodextrin and zeolite powder according to the ratio of 1: 0.8.
The plant extract comprises the following components in parts by weight: 3.5 parts of blackberry seed extract, 2.5 parts of vine tea extract and 0.5 part of tea saponin.
The blackberry seed extract and the vine tea extract are obtained by supercritical carbon dioxide extraction; when the blackberry seed extract is prepared, the technological parameters of supercritical carbon dioxide extraction are as follows: the extraction pressure is 30MPa, the extraction time is 2h, and the extraction temperature is 60 ℃; when preparing the vine tea extract, the technological parameters of supercritical carbon dioxide extraction are as follows: the extraction pressure is 22MPa, the extraction time is 2h, and the extraction temperature is 50 ℃.
The solid microecological preparation comprises the following components in parts by weight: 4 parts of cellobiose lactobacillus powder, 1.5 parts of bacillus licheniformis powder, 2 parts of bacillus natto powder and 3.5 parts of beer yeast powder.
The viable count of the cellobiose lactobacillus powder is 2.2 multiplied by 1010CFU/g; the viable count of the bacillus subtilis powder is 3.6 multiplied by 108CFU/g; the viable count of the bacillus natto powder is 1 multiplied by 109CFU/g; the viable bacteria number of the beer yeast powder is 5 multiplied by 109CFU/g。
Example 3:
a preparation method of a weaned pig feed additive capable of replacing antibiotics comprises the following steps: respectively crushing the plant extract, the solid microecological preparation, the tartaric acid and the carrier, sieving by a 100-mesh sieve, and then mixing the sieved powder of the plant extract, the solid microecological preparation, the tartaric acid and the carrier according to a ratio of 1: 0.5: 0.6: 3, the mixture is uniformly mixed.
Wherein the carrier is prepared from defatted rice bran and vermiculite powder according to the weight ratio of 1: 0.2, mixing and preparing.
The plant extract comprises the following components in parts by weight: 4 parts of blackberry seed extract, 2 parts of vine tea extract and 0.8 part of tea saponin.
The blackberry seed extract and the vine tea extract are obtained by supercritical carbon dioxide extraction; when the blackberry seed extract is prepared, the technological parameters of supercritical carbon dioxide extraction are as follows: the extraction pressure is 30MPa, the extraction time is 2h, and the extraction temperature is 65 ℃; when preparing the vine tea extract, the technological parameters of supercritical carbon dioxide extraction are as follows: the extraction pressure is 22MPa, the extraction time is 2h, and the extraction temperature is 52 ℃.
The solid microecological preparation comprises the following components in parts by weight: 4.2 parts of lactobacillus bulgaricus powder, 1.2 parts of bacillus licheniformis powder, 2.3 parts of bacillus natto powder and 3 parts of saccharomyces cerevisiae powder.
The number of viable bacteria of the Bulgaria lactobacillus powder is 3 multiplied by 1010CFU/g; the viable count of the bacillus subtilis powder is 4.5 multiplied by 108CFU/g; the viable count of the bacillus natto powder is 3 multiplied by 109CFU/g; the viable count of the beer yeast powder is 4 multiplied by 109CFU/g。
Example 4:
a preparation method of a weaned pig feed additive capable of replacing antibiotics comprises the following steps: respectively crushing the plant extract, the solid microecological preparation, the citric acid and the carrier, sieving by a 100-mesh sieve, and then mixing the sieved powder of the plant extract, the solid microecological preparation, the citric acid and the carrier according to a ratio of 1: 0.8: 0.5: 3.5, and mixing uniformly.
The carrier is prepared by mixing α -cyclodextrin and zeolite powder according to a ratio of 1: 0.5, the organic carrier is at least one of α -cyclodextrin, β -cyclodextrin, defatted rice bran and corn flour, and the inorganic carrier is at least one of zeolite powder and vermiculite powder.
The plant extract comprises the following components in parts by weight: 3.2 parts of blackberry seed extract, 1.8 parts of vine tea extract and 0.6 part of tea saponin.
The blackberry seed extract and the vine tea extract are obtained by supercritical carbon dioxide extraction; when the blackberry seed extract is prepared, the technological parameters of supercritical carbon dioxide extraction are as follows: the extraction pressure is 28MPa, the extraction time is 2.5h, and the extraction temperature is 60 ℃; when preparing the vine tea extract, the technological parameters of supercritical carbon dioxide extraction are as follows: the extraction pressure is 20MPa, the extraction time is 1.5h, and the extraction temperature is 50 ℃.
The solid microecological preparation comprises the following components in parts by weight: 3.3 parts of cellobiose lactobacillus powder, 0.9 part of bacillus licheniformis powder, 1.6 parts of bacillus natto powder and 2.8 parts of beer yeast powder.
The viable count of the cellobiose lactobacillus powder is 1 × 1010CFU/g; the viable count of the bacillus subtilis powder is 5 multiplied by 108CFU/g; the viable count of the Bacillus natto powder is 1.5 × 109CFU/g; the viable count of the beer yeast powder is 4.8 × 109CFU/g。
Example 5:
a preparation method of a weaned pig feed additive capable of replacing antibiotics comprises the following steps: respectively crushing the plant extract, the solid microecological preparation, the tartaric acid and the carrier, sieving by a 100-mesh sieve, and then mixing the sieved powder of the plant extract, the solid microecological preparation, the tartaric acid and the carrier according to a ratio of 1: 0.6: 0.4: 2.8 mass ratio, and mixing uniformly.
Wherein, the carrier is prepared from corn flour and vermiculite powder according to the weight ratio of 1: 0.8, mixing and preparing.
The plant extract comprises the following components in parts by weight: 3.5 parts of blackberry seed extract, 2.5 parts of vine tea extract and 0.5 part of tea saponin.
The blackberry seed extract and the vine tea extract are obtained by supercritical carbon dioxide extraction; when the blackberry seed extract is prepared, the technological parameters of supercritical carbon dioxide extraction are as follows: the extraction pressure is 27MPa, the extraction time is 2h, and the extraction temperature is 62 ℃; when preparing the vine tea extract, the technological parameters of supercritical carbon dioxide extraction are as follows: the extraction pressure is 24MPa, the extraction time is 1.5h, and the extraction temperature is 55 ℃.
The solid microecological preparation comprises the following components in parts by weight: 4 parts of lactobacillus acidophilus powder, 1.5 parts of bacillus licheniformis powder, 23 parts of bacillus natto powder and 3.6 parts of beer yeast powder.
Viable count of Lactobacillus acidophilus powderIs 2X 1010CFU/g; the viable count of the bacillus subtilis powder is 3 multiplied by 108CFU/g; the viable count of the bacillus natto powder is 1 multiplied by 109CFU/g; the viable count of the beer yeast powder is 7 multiplied by 109CFU/g。
Example 6:
a preparation method of a weaned pig feed additive capable of replacing antibiotics comprises the following steps: respectively crushing the plant extract, the solid microecological preparation, the citric acid and the carrier, sieving by a 100-mesh sieve, and then mixing the sieved powder of the plant extract, the solid microecological preparation, the citric acid and the carrier according to a ratio of 1: 0.5: 0.6: 3.2, and mixing uniformly.
Wherein the carrier is prepared by mixing β -cyclodextrin and vermiculite powder according to the ratio of 1: 0.5.
The plant extract comprises the following components in parts by weight: 3.5 parts of blackberry seed extract, 2 parts of vine tea extract and 0.6 part of tea saponin.
The blackberry seed extract and the vine tea extract are obtained by supercritical carbon dioxide extraction; when the blackberry seed extract is prepared, the technological parameters of supercritical carbon dioxide extraction are as follows: the extraction pressure is 30MPa, the extraction time is 2h, and the extraction temperature is 60 ℃; when preparing the vine tea extract, the technological parameters of supercritical carbon dioxide extraction are as follows: the extraction pressure is 22MPa, the extraction time is 2h, and the extraction temperature is 55 ℃.
The solid microecological preparation comprises the following components in parts by weight: 3.8 parts of lactobacillus powder, 1.1 parts of bacillus licheniformis powder, 2 parts of bacillus natto powder and 3 parts of beer yeast powder.
The viable count of the cellobiose lactobacillus powder is 2 multiplied by 1010CFU/g; the viable count of the bacillus subtilis powder is 3.6 multiplied by 108CFU/g; the viable count of the bacillus natto powder is 2 multiplied by 109CFU/g; the viable count of the beer yeast powder is 6 multiplied by 109CFU/g。
Comparative example 1:
a preparation method of a weaned pig feed additive comprises the following steps: respectively crushing the plant extract, the solid microecological preparation, the citric acid and the carrier, sieving by a 100-mesh sieve, and then mixing the sieved powder of the plant extract, the solid microecological preparation, the citric acid and the carrier according to a ratio of 1: 0.6: 0.5: 3.2, and mixing uniformly.
The plant extract comprises the following components in parts by weight: blackberry seed extract 3.5 weight portions and tea saponin 0.7 weight portions.
The blackberry seed extract was prepared as in example 1.
The composition of the solid microecological formulation and the carrier were the same as in example 1.
Comparative example 2:
a preparation method of a weaned pig feed additive comprises the following steps: respectively crushing the plant extract, the solid microecological preparation, the citric acid and the carrier, sieving by a 100-mesh sieve, and then mixing the sieved powder of the plant extract, the solid microecological preparation, the citric acid and the carrier according to a ratio of 1: 0.6: 0.5: 3.2, and mixing uniformly.
The plant extract comprises the following components in parts by weight: 2.1 parts of vine tea extract and 0.7 part of tea saponin.
The preparation method of Ampelopsis grossedentata extract is the same as in example 1.
The composition of the solid microecological formulation and the carrier were the same as in example 1.
Comparative example 3:
a preparation method of a weaned pig feed additive comprises the following steps: respectively crushing the plant extract, the solid microecological preparation, the citric acid and the carrier, sieving by a 100-mesh sieve, and then mixing the sieved powder of the plant extract, the solid microecological preparation, the citric acid and the carrier according to a ratio of 1: 0.6: 0.5: 3.2, and mixing uniformly.
The plant extract comprises the following components in parts by weight: blackberry seed extract 3.5 parts, and vine tea extract 2.1 parts.
The preparation method of blackberry seed extract and ampelopsis grossedentata extract is the same as that of example 1.
The composition of the solid microecological formulation and the carrier were the same as in example 1.
Feeding test:
1. test materials
Feed additive, oxytetracycline calcium in examples 1-6, comparative examples 1-3.
2. Test method
Selecting 500 ternary [ Du x (large x long) ] hybridization weaning piglets with the weight of about 9.3kg, carrying out a pre-test period of 7 days and a formal test period of 30 days, and randomly dividing the piglets into 10 groups according to the principle that the weights of halves of a male piglet and a female piglet are close to each other, wherein the 10 groups are respectively a test group 1-6, a comparison group 1-3 and a control group, and each group comprises 50 pigs.
The basal feed is formulated with reference to the nutritional needs of growing pigs in us NRC (2012)11-25kg, the composition and nutritional levels of which are shown in tables 1 and 2.
The basal feeds of the test groups 1 to 6 were added with 0.2% of the feed additives of examples 1 to 6, the basal feeds of the comparative groups 1 to 3 were added with 0.2% of the feed additives of comparative examples 1 to 3, and the basal feeds of the comparative groups were added with 0.01% of oxytetracycline calcium and 0.01% of aureomycin.
TABLE 1 basic feed composition
Figure BDA0002320616910000111
TABLE 2 basal feed nutritional levels
Figure BDA0002320616910000112
3. Feeding management
The feeding test is carried out in a certain pig farm, all the tested piglets are fed in a closed pigsty, the automatic trough is arranged, the ventilation is good, and the pigsty temperature is kept at 21-28 ℃. The piglets were kept in the unit of a pen, and were fed 2 times a day (09: 30 and 16: 30) with free water. The manure is cleared 2 times a day, and the house is kept clean.
4. Index measurement
All piglets in the test groups 1-6, the comparative groups 1-3 and the control group were subjected to fasting weighing on the morning on the 1 st day and the end day of the official start, the feed intake of each piglet was recorded, the average daily gain, the average daily feed intake, the feed-to-weight ratio and the diarrhea rate were calculated, and the specific results are shown in table 3.
TABLE 3 Effect of different feed additives on growth Performance of weaned piglets
Figure BDA0002320616910000121
As can be seen from Table 3, the feed additives of examples 1 to 6 of the present invention can effectively increase average daily gain and feed-to-weight ratio, and simultaneously can improve immunocompetence of piglets and effectively control diarrhea rate of piglets, and compared with a control group added with antibiotics, the feed additives are more environmentally friendly. The effect of the feed additive in the comparative examples 1-3 is worse than that in the examples 1-6, and the blackberry seed extract, the ampelopsis grossedentata extract and the tea saponin are synergistic and have better effect.
5. Feed additive adding amount determination
300 ternary [ Du x (large x long) ] hybridization weaning piglets with the weight of about 9.3kg are selected, the pre-test period is 7 days, the formal test period is 30 days, the piglets are randomly divided into 6 groups according to the principle that the weights of the halves of the male and female are close, the 6 groups are respectively 7-12, and each group has 50 pigs.
The feed additives of example 1 were added to the basal feeds of test groups 7 to 12 in an amount of 0.05%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, respectively.
The basic feed, the feeding management method and the index measuring method are the same as above. The specific measurement results are shown in table 4.
TABLE 4 Effect of different amounts of feed additives on growth Performance of weaned piglets
Figure BDA0002320616910000131
As is clear from Table 4, the effect was the best when the feed was added to the compound feed for feeding weaned piglets at a mass fraction of 0.1 to 0.25%, particularly at 0.15%.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims (10)

1. The feed additive for weaned pigs capable of replacing antibiotics is characterized by comprising plant extracts, a solid microecological preparation, a solid organic acid and a carrier in a mass ratio of 1: 0.5-0.8: 0.4-0.6: 2.8-3.5;
the plant extract comprises the following components in parts by weight: 3.2-4 parts of blackberry seed extract, 1.8-2.5 parts of vine tea extract and 0.5-0.8 part of tea saponin;
the solid microecological preparation comprises the following components in parts by weight: 3.3-4.2 parts of lactobacillus powder, 0.9-1.5 parts of bacillus licheniformis powder, 1.6-2.3 parts of bacillus natto powder and 2.8-3.6 parts of saccharomyces cerevisiae powder.
2. The antibiotic-replaceable weaned pig feed additive according to claim 1, wherein the blackberry seed extract and the ampelopsis grossedentata extract are both obtained by supercritical carbon dioxide extraction;
when the blackberry seed extract is prepared, the technological parameters of supercritical carbon dioxide extraction are as follows: the extraction pressure is 27-30MPa, the extraction time is 2-2.5h, and the extraction temperature is 60-65 ℃;
when preparing the vine tea extract, the technological parameters of supercritical carbon dioxide extraction are as follows: the extraction pressure is 20-24MPa, the extraction time is 1.5-2h, and the extraction temperature is 50-55 ℃.
3. The antibiotic-replaceable weaned pig feed additive according to claim 1, wherein the carrier is prepared by mixing an organic carrier and an inorganic carrier according to a mass ratio of 1: 0.2-0.8, wherein the organic carrier is at least one of α -cyclodextrin, β -cyclodextrin, defatted rice bran and corn flour, and the inorganic carrier is at least one of zeolite powder and vermiculite powder.
4. The antibiotic-replaceable weaned piglet feed additive according to claim 1, wherein the solid organic acid is citric acid or tartaric acid.
5. The antibiotic-replaceable weaned piglet feed additive according to claim 1, wherein the viable count of said lactobacillus powder is 1-3 x 1010CFU/g; the viable count of the bacillus subtilis powder is 3-5 multiplied by 108CFU/g; the viable count of the bacillus natto powder is 1-3 multiplied by 109CFU/g; the viable count of the beer yeast powder is 4-7 × 109CFU/g。
6. The antibiotic-replaceable weaned piglet feed additive according to claim 1, wherein the lactobacillus powder is at least one of lactobacillus acidophilus, lactobacillus cellobiosus, and lactobacillus bulgaricus.
7. The antibiotic-replaceable weaned piglet feed additive according to claim 1, wherein the feed additive is prepared from plant extracts, solid probiotics, solid organic acids and carriers in a mass ratio of 1: 0.6: 0.5: 3.2, the preparation.
8. The antibiotic-replaceable weaned pig feed additive according to claim 1, wherein the preparation method of the feed additive comprises the following steps: respectively crushing the plant extract, the solid microecological preparation, the solid organic acid and the carrier, sieving by a 100-mesh sieve, and uniformly mixing the sieved powder of the plant extract, the solid microecological preparation, the solid organic acid and the carrier according to the mass ratio.
9. Use of a weaned pig feed additive as described in any of claims 1-8 as an antibiotic substitute in weaned pig feeding.
10. The use according to claim 9, wherein the antibiotic-replaceable weaned pig feed additive is added to a basal feed for feeding weaned pigs in a mass fraction of 0.1-0.25%.
CN201911296180.1A 2019-12-16 2019-12-16 Weaned pig feed additive capable of replacing antibiotics and application thereof Withdrawn CN110892944A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112167455A (en) * 2020-10-14 2021-01-05 四川省旺达饲料有限公司 Green additive composition for weaned piglets, preparation method and application method
CN113841792A (en) * 2021-12-01 2021-12-28 潍坊加易加生物科技有限公司 Feed additive composition based on tea saponin as solubilizer
CN114158653A (en) * 2021-06-24 2022-03-11 山东绿都安特动物药业有限公司 Additive premix feed for improving non-specific immune function of weaned piglets

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112167455A (en) * 2020-10-14 2021-01-05 四川省旺达饲料有限公司 Green additive composition for weaned piglets, preparation method and application method
CN114158653A (en) * 2021-06-24 2022-03-11 山东绿都安特动物药业有限公司 Additive premix feed for improving non-specific immune function of weaned piglets
CN114158653B (en) * 2021-06-24 2023-10-24 山东绿都安特动物药业有限公司 Additive premix feed for improving nonspecific immunity of weaned pigs
CN113841792A (en) * 2021-12-01 2021-12-28 潍坊加易加生物科技有限公司 Feed additive composition based on tea saponin as solubilizer
CN113841792B (en) * 2021-12-01 2022-03-15 潍坊加易加生物科技有限公司 Feed additive composition based on tea saponin as solubilizer

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