CN112244163A - Antibiotic-free piglet feed additive and preparation method and application method thereof - Google Patents
Antibiotic-free piglet feed additive and preparation method and application method thereof Download PDFInfo
- Publication number
- CN112244163A CN112244163A CN202011099144.9A CN202011099144A CN112244163A CN 112244163 A CN112244163 A CN 112244163A CN 202011099144 A CN202011099144 A CN 202011099144A CN 112244163 A CN112244163 A CN 112244163A
- Authority
- CN
- China
- Prior art keywords
- antibiotic
- feed additive
- potassium diformate
- piglet feed
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003674 animal food additive Substances 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims abstract description 15
- BINNZIDCJWQYOH-UHFFFAOYSA-M potassium;formic acid;formate Chemical compound [K+].OC=O.[O-]C=O BINNZIDCJWQYOH-UHFFFAOYSA-M 0.000 claims abstract description 74
- 239000004375 Dextrin Substances 0.000 claims abstract description 41
- 229920001353 Dextrin Polymers 0.000 claims abstract description 41
- 235000019425 dextrin Nutrition 0.000 claims abstract description 41
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 39
- 239000005017 polysaccharide Substances 0.000 claims abstract description 39
- 238000001179 sorption measurement Methods 0.000 claims abstract description 26
- 239000011162 core material Substances 0.000 claims abstract description 16
- 238000013268 sustained release Methods 0.000 claims abstract description 16
- 239000012730 sustained-release form Substances 0.000 claims abstract description 16
- 240000007849 Macleaya cordata Species 0.000 claims abstract description 14
- 239000000843 powder Substances 0.000 claims abstract description 14
- 239000011257 shell material Substances 0.000 claims abstract description 14
- 150000004676 glycans Chemical class 0.000 claims abstract 8
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 32
- 238000010438 heat treatment Methods 0.000 claims description 26
- 239000001103 potassium chloride Substances 0.000 claims description 16
- 235000011164 potassium chloride Nutrition 0.000 claims description 16
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 14
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 12
- 238000001694 spray drying Methods 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 241000186684 Lactobacillus pentosus Species 0.000 claims description 9
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000004408 titanium dioxide Substances 0.000 claims description 7
- 229920001661 Chitosan Polymers 0.000 claims description 6
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 5
- 235000010413 sodium alginate Nutrition 0.000 claims description 5
- 239000000661 sodium alginate Substances 0.000 claims description 5
- 229940005550 sodium alginate Drugs 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 3
- 230000001937 non-anti-biotic effect Effects 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 235000000023 Auricularia auricula Nutrition 0.000 claims description 2
- 241001149430 Auricularia auricula-judae Species 0.000 claims description 2
- 235000014590 basal diet Nutrition 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 abstract description 11
- 230000028327 secretion Effects 0.000 abstract description 11
- 210000002784 stomach Anatomy 0.000 abstract description 7
- 230000001580 bacterial effect Effects 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- 210000000936 intestine Anatomy 0.000 abstract description 3
- 150000004804 polysaccharides Chemical class 0.000 description 30
- 241000894006 Bacteria Species 0.000 description 14
- 210000001035 gastrointestinal tract Anatomy 0.000 description 13
- 238000012360 testing method Methods 0.000 description 10
- 239000003242 anti bacterial agent Substances 0.000 description 9
- 239000000126 substance Substances 0.000 description 6
- 206010012735 Diarrhoea Diseases 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 5
- 229910052500 inorganic mineral Inorganic materials 0.000 description 5
- 235000010755 mineral Nutrition 0.000 description 5
- 239000011707 mineral Substances 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 241000282887 Suidae Species 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000002354 daily effect Effects 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 244000144972 livestock Species 0.000 description 3
- 239000002808 molecular sieve Substances 0.000 description 3
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 235000021050 feed intake Nutrition 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 230000003405 preventing effect Effects 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 241000221377 Auricularia Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 235000019764 Soybean Meal Nutrition 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000000274 adsorptive effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229920001586 anionic polysaccharide Polymers 0.000 description 1
- 150000004836 anionic polysaccharides Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- -1 cationic polysaccharide Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000005253 cladding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 235000019621 digestibility Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 239000012286 potassium permanganate Substances 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 235000013594 poultry meat Nutrition 0.000 description 1
- 235000013613 poultry product Nutrition 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- 229910052678 stilbite Inorganic materials 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/167—Pentosus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Birds (AREA)
- Botany (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Fodder In General (AREA)
Abstract
The invention relates to the technical field of feed additives, and discloses an antibiotic-free piglet feed additive which is characterized by comprising 15 to 20 parts by weight of potassium diformate slow release carrier, 5 to 10 parts by weight of macleaya cordata powder and 5 to 8 parts by weight of microecological preparation; the potassium diformate sustained-release carrier is prepared by taking adsorption type polysaccharide as a shell material and potassium diformate-resistant dextrin as a core material. Also discloses a preparation method and an application method. Adopt the feed additive of this application, can imbed potassium diformate effectively, promote potassium diformate's slow release nature, the adsorption type polysaccharide can effectual absorption intestinal bacterial secretion simultaneously, avoids the bacterial secretion to adsorb in intestinal inner wall, can protect intestines and stomach inner wall better.
Description
Technical Field
The invention belongs to the technical field of feed additives, and particularly relates to an antibiotic-free piglet feed additive and a preparation method and an application method thereof.
Background
With the improvement of living standard, people have higher and higher demand for food safety. Antibiotics have been widely used in livestock breeding because of their growth promoting and disease preventing effects. However, the serious consequence of the use of antibiotics in large quantities is drug residues, which affect the quality safety of the feed and the food safety. Therefore, research and development of a substance capable of replacing antibiotics are urgently needed, and the substance can promote the growth and development of piglets.
The potassium diformate has the effects of resisting bacterial infection and improving the digestibility of the feed, but the potassium diformate has poor oral bioavailability, is easy to decompose and absorb in the stomach of animals, has a stimulation effect on gastric mucosa, and cannot reach the intestines and stomach to effectively reduce the pH of the intestinal tract and inhibit the growth of bacteria such as escherichia coli and the like.
A solution to the above-described technical problem can be found in patent document 1, and the details of patent document 1 will be described.
< patent document >
Patent document 1: publication No. CN109731103A
Patent document 1 discloses a method for preparing a P-type molecular sieve-chitosan-sodium alginate-potassium diformate sustained-release antibacterial agent, comprising the steps of treating stilbite to prepare a molecular sieve, adsorbing potassium diformate by the molecular sieve to prepare a sustained-release antibacterial agent core material, and reacting the core material with chitosan and sodium alginate to form the sustained-release antibacterial agent, wherein the sustained-release antibacterial agent can be used for preventing and treating diarrhea caused by escherichia coli.
The molecular sieve is synthesized by taking natural minerals as raw materials, is economic and environment-friendly, can open up a new way for high-added-value utilization of the natural minerals, but because the components and the structure of the minerals are complex, the mineral materials need to be subjected to pretreatment such as impurity removal, activation and the like before use, so that the mineral materials are converted into active components needed in a synthesis system.
Disclosure of Invention
The invention aims to provide an antibiotic-free piglet feed additive for solving the problems of complex preparation process and high manufacturing cost of the conventional slow-release antibacterial agent. And the feed additive of this application not only can embed potassium diformate effectively, promotes potassium diformate's slow release nature, and adsorption type polysaccharide can effectual absorption intestinal bacterium secretion simultaneously, avoids the bacterium secretion to adsorb in intestinal inner wall, can protect intestines and stomach inner wall better.
Specifically, the antibiotic-free piglet feed additive comprises, by weight, 15-20 parts of potassium diformate slow release carrier, 5-10 parts of macleaya cordata powder and 5-8 parts of microecological preparation; the potassium diformate sustained-release carrier is prepared by taking adsorption type polysaccharide as a shell material and potassium diformate-resistant dextrin as a core material.
The feed additive comprises a potassium diformate slow release carrier, macleaya cordata powder and a microecological preparation, wherein the potassium diformate slow release carrier can improve the utilization rate of the potassium diformate, prevent the potassium diformate from entering intestinal tracts to be digested and absorbed, and enable the potassium diformate to continuously act on intestinal flora, regulate the pH value of the intestinal tracts and destroy the growth environment of harmful bacteria through the preparation of the slow release carrier. The macleaya cordata powder can effectively help livestock and poultry to improve the intestinal environment, resist various infectious diseases and obviously reduce the use of antibiotics, which is beneficial to improving the quality of livestock and poultry products and the food safety. The microecological preparation can improve the utilization rate of the feed by animals, supplement various nutrient substances and further improve the production performance of the animals.
The potassium diformate sustained release carrier is prepared by taking adsorption type polysaccharide as a shell material and potassium diformate-resistant dextrin as a core material. The resistant dextrin is dietary fiber which has strong acid and alkali resistance and strong water solubility and is a blend interacting with potassium diformate. The resistant dextrin contains both straight-chain starch and branched-chain starch, and can be subjected to a grafting reaction with a group in potassium diformate to form a resistant dextrin-potassium diformate compound. The resistant dextrin-potassium diformate compound can avoid the decomposition and absorption of potassium diformate, promote the intestinal tract to wriggle and promote digestion, harmful bacteria exist in the intestinal tract besides probiotics, and the resistant dextrin can reduce the retention of harmful bacteria secretion in the intestinal tract and reduce the contact chance of toxic and harmful substances and the intestinal tract. The potassium diformate-resistant dextrin is used as a core material, so that the potassium diformate can be effectively embedded, the slow release property of the potassium diformate is improved, and meanwhile, the adsorption type polysaccharide can effectively adsorb intestinal bacteria secretion, and the bacteria secretion is prevented from being adsorbed on the inner wall of an intestinal tract. Meanwhile, the resistant dextrin can form a compound with the anionic polysaccharide, the cationic polysaccharide and the neutral polysaccharide, so that a cross-linked substance is formed between the resistant dextrin and the adsorption type polysaccharide, and the resistant dextrin, the adsorption type polysaccharide and the bacterial secretion are discharged out of the intestinal tract together in the intestinal tract peristalsis process.
The second purpose of the invention is to provide a preparation method of the antibiotic-free piglet feed additive, which comprises the following steps:
s1, weighing the adsorption polysaccharide in proportion, dissolving the adsorption polysaccharide in water to form a polysaccharide solution with the mass fraction of 3% -5%, adding the weighed potassium diformate-resistant dextrin, and stirring for 0.5-1 h under the ultrasonic condition to form mixed feed liquid;
s2, spray drying the mixed material liquid, and carrying out dry heat treatment on the mixture after spray drying to obtain a potassium diformate slow release carrier;
s3, uniformly mixing the dicarboxylic acid slow-release carrier with the macleaya cordata powder and the microecological preparation to obtain the antibiotic-free piglet feed additive.
The third purpose of the invention is to provide an application method of the antibiotic-free piglet feed additive, wherein the antibiotic-free piglet feed additive is added into basic ration of weaned piglets, and the adding proportion of the antibiotic-free piglet feed additive is 0.5-3% by weight percent.
The beneficial effects of the invention are as follows:
adopt the feed additive of this application to resistant dextrin and potassium diformate interact can avoid the decomposition of potassium diformate, still can promote the wriggling of intestinal simultaneously, reduces the utilization of stomach to nutrient substance, uses the adsorption type polysaccharide as the shell material again, carries out the cladding to resistant dextrin-potassium diformate and handles, makes potassium diformate play slow-release effect, and the bacterial secretion in the adsorption type polysaccharide can adsorb the intestinal, avoids causing the damage to the intestinal, thereby reduces the diarrhea.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
The invention provides an antibiotic-free piglet feed additive, which comprises 15 to 20 parts of potassium diformate slow release carrier, 5 to 10 parts of macleaya cordata powder and 5 to 8 parts of microecological preparation by weight; the potassium diformate sustained-release carrier is prepared by taking adsorption type polysaccharide as a shell material and potassium diformate-resistant dextrin as a core material.
The preparation method of the potassium diformate-resistant dextrin comprises the step of putting the resistant dextrin, potassium chloride and potassium diformate into a heating chamber for dry heat treatment, wherein the adding mass ratio of the potassium diformate, the potassium chloride and the resistant dextrin is 0.2-1: 0.3-1: 10-15. The potassium chloride is used for supplying the resistant dextrin for ionization treatment, so that covalent crosslinking is formed between the resistant dextrin and the potassium diformate.
In the invention, potassium diformate, potassium chloride and resistant dextrin are subjected to dry heat treatment at 110-130 ℃ for 0.5-1 h.
The invention also comprises titanium dioxide, and the addition amount of the titanium dioxide is 0.02-0.5 part. The titanium dioxide has bactericidal property and can inhibit the propagation and growth of harmful flora in intestinal tract.
In the invention, the core material accounts for 10 to 15 parts, and the shell material accounts for 3 to 5 parts.
In the invention, the adsorption polysaccharide comprises at least one of agaric polysaccharide, chitosan and sodium alginate. Auricularia polysaccharide, chitosan and sodium alginate not only can be embedded with resistant dextrin, can also form the cross-linking with resistant dextrin simultaneously, promote its slow-release effect, can also wrap in the bacterium secretion to carry the bacterium secretion out of the stomach, avoid causing the damage to the animal stomach.
According to the invention, the microecological preparation comprises bacillus, lactobacillus rhamnosus and lactobacillus pentosus, and the mass ratio of the bacillus to the lactobacillus rhamnosus to the lactobacillus pentosus is 1-1.2: 0.5-1: 1. The combination of the bacillus is beneficial to maintaining the quantity of beneficial bacteria in intestinal tracts of piglets and inhibiting the propagation of harmful bacteria, so that the good state of weaning is kept, and the flora can be quickly stabilized. When the piglets are weaned, beneficial bacteria such as lactic acid bacteria and bacillus are taken as soon as possible, oxygen in intestinal tracts is consumed through the bacillus, growth of anaerobic bacteria such as the lactobacillus is facilitated, and meanwhile, a large amount of organic acid is generated to inhibit propagation of escherichia coli, so that intestinal flora is kept balanced, and diseases are prevented.
Secondly, the preparation method of the antibiotic-free piglet feed additive comprises the following steps:
s1, weighing the adsorption polysaccharide in proportion, dissolving the adsorption polysaccharide in water to form a polysaccharide solution with the mass fraction of 3% -5%, adding the weighed potassium diformate-resistant dextrin, and stirring for 0.5-1 h under the ultrasonic condition to form mixed feed liquid;
s2, spray drying the mixed material liquid, and carrying out dry heat treatment on the mixture after spray drying to obtain a potassium diformate slow release carrier;
s3, uniformly mixing the dicarboxylic acid slow-release carrier with the macleaya cordata powder and the microecological preparation to obtain the antibiotic-free piglet feed additive.
In the invention, the dry heat treatment process parameters are that the mixture is dried until the water content is lower than 10%, the dry heat temperature is 130-150 ℃, and the dry heat time is 0.5-1 h.
Thirdly, the invention provides an application method of the antibiotic-free piglet feed additive, which is characterized in that the antibiotic-free piglet feed additive is added into basic ration of weaned piglets, and the adding proportion of the antibiotic-free piglet feed additive is 2-5% by weight percentage.
< example >
Example 1
The antibiotic-free piglet feed additive comprises, by weight, 18 parts of potassium diformate slow-release carrier, 5 parts of macleaya cordata powder, 3 parts of bacillus, 1.5 parts of lactobacillus rhamnosus and 3 parts of lactobacillus pentosus. The potassium diformate sustained release carrier is prepared by taking adsorption type polysaccharide as a shell material and potassium diformate-resistant dextrin as a core material, and the adsorption type polysaccharide is chitosan.
The preparation method of the potassium diformate sustained-release carrier comprises the following steps of (1) putting the resistant dextrin, the potassium chloride and the potassium diformate into a heating chamber for dry heat treatment, wherein the adding mass ratio of the potassium diformate, the potassium chloride and the resistant dextrin is 0.5:0.5: 12. The potassium diformate, potassium chloride and resistant dextrin were dry heat treated at 120 ℃ for 0.5 h. (2) The mass ratio of the shell material to the core material is 12:3, the adsorption type polysaccharide is weighed according to the proportion and then dissolved in water to form polysaccharide solution with the mass fraction of 3%, and potassium diformate-resistant dextrin which is weighed according to the proportion is added and stirred for 0.5h under the ultrasonic condition to form mixed feed liquid; and (3) carrying out spray drying on the mixed material liquid, and carrying out dry heat treatment on the mixture after spray drying, wherein the dry heat treatment temperature is 130 ℃, and the dry heat treatment time is 0.5h, so as to obtain the potassium diformate sustained-release carrier. The adsorption polysaccharide is chitosan.
The preparation method of the antibiotic-free piglet feed additive comprises the step of mixing the potassium diformate slow-release carrier, the macleaya cordata powder, the bacillus, the lactobacillus rhamnosus and the lactobacillus pentosus according to a proportion.
Example 2
The difference between the embodiment and the embodiment 1 is that the non-antibiotic piglet feed additive has different weight parts of each component, and specifically comprises 18 parts of potassium diformate slow release carrier, 10 parts of macleaya cordata powder, 1.5 parts of bacillus, 0.8 part of lactobacillus rhamnosus and 2.7 parts of lactobacillus pentosus.
Example 3
The difference between the embodiment and the embodiment 1 is that the non-antibiotic piglet feed additive has different weight parts of each component, and specifically comprises 15 parts of potassium diformate slow release carrier, 8 parts of macleaya cordata powder, 3.5 parts of bacillus, 1.8 parts of lactobacillus rhamnosus and 1 part of lactobacillus pentosus.
Example 4
The present example differs from example 1 in that the ratio of shell material to core material is different, specifically 15: 5.
Example 5
The present example differs from example 1 in that the ratio of shell material to core material is different, specifically 10: 3.
Example 6
This example is different from example 1 in that 0.3 part of titanium dioxide was further included.
Example 7
This example is different from example 1 in that 0.02 parts of titanium dioxide was further included.
Example 8
This example differs from example 1 in that the adsorptive polysaccharide is selected from the group consisting of auricularia auricula polysaccharide, sodium alginate, and combinations thereof.
Example 9
This example is different from example 1 in the preparation method of the potassium diformate sustained release carrier. Specifically, the method comprises the following steps: (1) and (3) putting the resistant dextrin, the potassium chloride and the potassium diformate into a heating chamber for dry heat treatment, wherein the adding mass ratio of the potassium diformate to the potassium chloride to the resistant dextrin is 0.2:1: 10. Potassium diformate, potassium chloride and resistant dextrin were dry heat treated at 110 ℃ for 1 h. (2) The mass ratio of the shell material to the core material is 12:3, the adsorption type polysaccharide is weighed according to the proportion and then dissolved in water to form polysaccharide solution with the mass fraction of 5%, potassium diformate-resistant dextrin weighed according to the proportion is added, and the mixture is stirred for 1 hour under the ultrasonic condition to form mixed feed liquid; and (3) carrying out spray drying on the mixed material liquid, and carrying out dry heat treatment on the mixture after spray drying, wherein the dry heat treatment temperature is 150 ℃, and the dry heat treatment time is 1h, so as to obtain the potassium diformate sustained release carrier.
Example 10
This example is different from example 1 in the preparation method of the potassium diformate sustained release carrier. Specifically, the method comprises the following steps: (1) and (3) putting the resistant dextrin, the potassium chloride and the potassium diformate into a heating chamber for dry heat treatment, wherein the adding mass ratio of the potassium diformate to the potassium chloride to the resistant dextrin is 1:0.3: 15. The potassium diformate, potassium chloride and resistant dextrin were dry heat treated at 130 ℃ for 0.8 h. (2) The mass ratio of the shell material to the core material is 12:3, the adsorption type polysaccharide is weighed according to the proportion and then dissolved in water to form polysaccharide solution with the mass fraction of 3%, and potassium diformate-resistant dextrin which is weighed according to the proportion is added and stirred for 0.5h under the ultrasonic condition to form mixed feed liquid; and (3) carrying out spray drying on the mixed material liquid, and carrying out dry heat treatment on the mixture after spray drying, wherein the dry heat treatment temperature is 130 ℃, and the dry heat treatment time is 0.5h, so as to obtain the potassium diformate sustained-release carrier.
< comparative example >
Comparative example 1
A feed additive comprises, by weight, 18 parts of montmorillonite-potassium diformate, 5 parts of macleaya cordata powder, 3 parts of bacillus, 1.5 parts of lactobacillus rhamnosus and 3 parts of lactobacillus pentosus.
< test example >
The tests were carried out using examples 1 to 6 and comparative example 1 as test samples.
Piglets (half of the male and the female) with the average weight of 15kg are selected, the piglets are randomly divided into 7 groups according to the principle that the weights and the sexes are consistent, each group has 6 repetitions, each repetition has 10 pigs, and the nutrition requirement of NPC pigs is used as the standard for the experimental group and the control group. The feed adopts corn and soybean meal as basic daily ration, the adding weight proportion of the feed additive is 3%, and in other test modes, the adding weight proportion can be 2% and 5%. The weight of the experimental piglet reaches 30kg and the application is finished. The pen house was thoroughly cleaned before the test, rinsed with 2% NaOH, fumigated with formalin and potassium permanganate at a ratio of 2:1 for several hours, ventilated and cleaned for one week, and the test was started. During the test period, powdery materials are regularly fed at eight am and five pm every day, pigs are fed and drunk freely, the health conditions of the pigs are observed and recorded, and the feed intake in the whole period is recorded. The test period determination indexes comprise: average daily gain, material weight ratio and diarrhea rate.
The test results are shown in table 1.
TABLE 1 piglet test results
Group of | Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | Example 6 | Comparative example 1 |
Daily gain | 523 | 518 | 520 | 515 | 510 | 528 | 480 |
Material to weight ratio | 2.21 | 2.25 | 2.24 | 2.29 | 2.31 | 2.17 | 2.48 |
Rate of diarrhea | 1.8 | 2.0 | 1.8 | 2.1 | 2.2 | 1.7 | 2.5 |
As shown in the experimental results of Table 1, the feed of the piglets in the examples can promote the feed intake and effectively reduce the diarrhea rate of the piglets.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The antibiotic-free piglet feed additive is characterized by comprising 15 to 20 parts by weight of potassium diformate slow release carrier, 5 to 10 parts by weight of macleaya cordata powder and 5 to 8 parts by weight of microecological preparation; the potassium diformate sustained-release carrier is prepared by taking adsorption type polysaccharide as a shell material and potassium diformate-resistant dextrin as a core material.
2. The antibiotic-free piglet feed additive according to claim 1, wherein the potassium diformate-resistant dextrin is prepared by the method comprising,
and (3) putting the resistant dextrin, potassium chloride and potassium diformate into a heating chamber for dry heat treatment, wherein the adding mass ratio of the potassium diformate to the potassium chloride to the resistant dextrin is 0.2-1: 0.3-1: 10-15.
3. The antibiotic-free piglet feed additive according to claim 2, wherein the potassium diformate, the potassium chloride and the resistant dextrin are subjected to dry heat treatment at 110-130 ℃ for 0.5-1 h.
4. The antibiotic-free piglet feed additive according to claim 2, which further comprises titanium dioxide, wherein the addition amount of the titanium dioxide is 0.02-0.5 parts.
5. The antibiotic-free piglet feed additive according to claim 1, wherein the components comprise, by weight, 10-15 parts of core material and 3-5 parts of shell material.
6. The antibiotic-free piglet feed additive according to claim 1, wherein the adsorption type polysaccharide comprises at least one of auricularia auricula polysaccharide, chitosan, or sodium alginate.
7. The antibiotic-free piglet feed additive according to claim 1 or 2, wherein the microecological preparation comprises bacillus, lactobacillus rhamnosus and lactobacillus pentosus, and the mass ratio of the bacillus, the lactobacillus rhamnosus and the lactobacillus pentosus is 1-1.2: 0.5-1: 1.
8. A method for preparing a non-antibiotic piglet feed additive according to any one of claims 1 to 7, which comprises the following steps:
s1, weighing the adsorption polysaccharide in proportion, dissolving the adsorption polysaccharide in water to form a polysaccharide solution with the mass fraction of 3% -5%, adding the weighed potassium diformate-resistant dextrin, and stirring for 0.5-1 h under the ultrasonic condition to form mixed feed liquid;
s2, spray drying the mixed material liquid, and carrying out dry heat treatment on the mixture after spray drying to obtain a potassium diformate slow release carrier;
s3, uniformly mixing the dicarboxylic acid slow-release carrier with the macleaya cordata powder and the microecological preparation to obtain the antibiotic-free piglet feed additive.
9. The preparation method of the antibiotic-free piglet feed additive according to claim 8, wherein the dry heat treatment process parameters are that the mixture is dried until the water content is lower than 10%, the dry heat temperature is 130-150 ℃, and the dry heat time is 0.5-1 h.
10. The application method of the antibiotic-free piglet feed additive according to any one of claims 1 to 9, wherein the antibiotic-free piglet feed additive is added into basal diet of weaned piglets, and the adding proportion of the antibiotic-free piglet feed additive is 2-5% by weight percentage.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011099144.9A CN112244163A (en) | 2020-10-14 | 2020-10-14 | Antibiotic-free piglet feed additive and preparation method and application method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011099144.9A CN112244163A (en) | 2020-10-14 | 2020-10-14 | Antibiotic-free piglet feed additive and preparation method and application method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN112244163A true CN112244163A (en) | 2021-01-22 |
Family
ID=74242583
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202011099144.9A Pending CN112244163A (en) | 2020-10-14 | 2020-10-14 | Antibiotic-free piglet feed additive and preparation method and application method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN112244163A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114431339A (en) * | 2022-02-14 | 2022-05-06 | 浙江汇能生物股份有限公司 | Low-additive stability-enhancing microencapsulated potassium diformate feed additive and preparation method thereof |
CN114514955A (en) * | 2022-02-14 | 2022-05-20 | 浙江汇能生物股份有限公司 | Composite coated potassium diformate microcapsule and preparation process thereof |
CN115843935A (en) * | 2022-11-09 | 2023-03-28 | 湖北润泛生物科技有限公司 | Piglet feed additive and preparation method and application thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107173599A (en) * | 2017-06-15 | 2017-09-19 | 漳州傲农牧业科技有限公司 | A kind of feed addictive for mitigating weaned piglet syndrome and preparation method and application |
CN107889938A (en) * | 2017-11-21 | 2018-04-10 | 常州市蓝勖化工有限公司 | A kind of preparation method of spacetabs type fodder acidulant |
CN109731103A (en) * | 2019-01-20 | 2019-05-10 | 桂林理工大学 | P-zeolite-chitin-sodium alginate-potassium diformate sustained-release antibacterial agent preparation method |
CN110787135A (en) * | 2019-11-19 | 2020-02-14 | 桂林理工大学 | Preparation method of green chitosan/carboxymethyl cellulose/P type molecular sieve/potassium diformate sustained-release antibacterial microspheres |
-
2020
- 2020-10-14 CN CN202011099144.9A patent/CN112244163A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107173599A (en) * | 2017-06-15 | 2017-09-19 | 漳州傲农牧业科技有限公司 | A kind of feed addictive for mitigating weaned piglet syndrome and preparation method and application |
CN107889938A (en) * | 2017-11-21 | 2018-04-10 | 常州市蓝勖化工有限公司 | A kind of preparation method of spacetabs type fodder acidulant |
CN109731103A (en) * | 2019-01-20 | 2019-05-10 | 桂林理工大学 | P-zeolite-chitin-sodium alginate-potassium diformate sustained-release antibacterial agent preparation method |
CN110787135A (en) * | 2019-11-19 | 2020-02-14 | 桂林理工大学 | Preparation method of green chitosan/carboxymethyl cellulose/P type molecular sieve/potassium diformate sustained-release antibacterial microspheres |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114431339A (en) * | 2022-02-14 | 2022-05-06 | 浙江汇能生物股份有限公司 | Low-additive stability-enhancing microencapsulated potassium diformate feed additive and preparation method thereof |
CN114514955A (en) * | 2022-02-14 | 2022-05-20 | 浙江汇能生物股份有限公司 | Composite coated potassium diformate microcapsule and preparation process thereof |
CN114514955B (en) * | 2022-02-14 | 2023-05-23 | 浙江汇能生物股份有限公司 | Composite coated potassium diformate microcapsule and preparation process thereof |
CN114431339B (en) * | 2022-02-14 | 2023-06-27 | 浙江汇能生物股份有限公司 | Low-additive stability-increasing microencapsulated potassium diformate feed additive and preparation method thereof |
CN115843935A (en) * | 2022-11-09 | 2023-03-28 | 湖北润泛生物科技有限公司 | Piglet feed additive and preparation method and application thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN112244163A (en) | Antibiotic-free piglet feed additive and preparation method and application method thereof | |
CN101120758B (en) | Liquid acidifier and preparation method | |
CN1309311C (en) | Biological active acidating agent for feeding and its preparation | |
CN103005160A (en) | Compound acidifier for feed, and preparation method and application of acidifier | |
CN109874919A (en) | A kind of additive agent for feeding, preparation method and applications | |
CN110892947A (en) | Compound acidifier for poultry and preparation method and application thereof | |
CN111903849A (en) | Feed additive for replacing antibiotics and preparation method thereof | |
CN106721055A (en) | Feeding coating compound acidulant and preparation method thereof | |
US7001625B2 (en) | Solid phase synthesis of salts of organic acids including butyric acid | |
CN114747688A (en) | 'four-in-one' combined additive capable of improving intestinal functions of dogs and cats and preparation method thereof | |
CN110787135A (en) | Preparation method of green chitosan/carboxymethyl cellulose/P type molecular sieve/potassium diformate sustained-release antibacterial microspheres | |
KR100262110B1 (en) | Feed-additive by chitosan and mixed-feed preparation method by using it. | |
CN101999519B (en) | Preparation method of deodorization conditioner for bacillus megaterium | |
CN102823771A (en) | Biological active acidifying agent for piglets, premix compound and compound | |
CN110140814A (en) | A kind of class fermented type mixed feed and the preparation method and application thereof | |
CS201006B2 (en) | Fodder and admixture in the fodder | |
CN104982669A (en) | Organic compound acidifier added in domestic rabbit high-fiber feed and preparation method thereof | |
CN114747687A (en) | Pet daily ration processing technology for adjusting intestinal flora and immunity of dogs or cats and pet daily ration | |
CN113424903A (en) | Pig feed additive, preparation method and pig feed thereof | |
CN111084287A (en) | Feed for improving immunity of piglets and preparation method thereof | |
CN112568331A (en) | Feed additive coated compound acidifier and production method thereof | |
CN111700152A (en) | Antibiotic-free feed prepared by microbial fermentation and preparation process thereof | |
CN108419917B (en) | Preparation method of oligosaccharide-containing sodium humate product | |
CN111567694A (en) | Nutritional composition for reducing pet excrement peculiar smell and preparation method thereof | |
CN110946215A (en) | Antibacterial complex enzyme preparation and application thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210122 |