CN102578387B - A kind of slowly-releasing compound acidulant for animal and fowl fodder and preparation method thereof and feed - Google Patents
A kind of slowly-releasing compound acidulant for animal and fowl fodder and preparation method thereof and feed Download PDFInfo
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- CN102578387B CN102578387B CN201210023755.4A CN201210023755A CN102578387B CN 102578387 B CN102578387 B CN 102578387B CN 201210023755 A CN201210023755 A CN 201210023755A CN 102578387 B CN102578387 B CN 102578387B
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
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Abstract
The invention discloses a kind of slowly-releasing compound acidulant for animal and fowl fodder, its preparation method and the feed containing it.This compound acidulant contains composite organic acid, auxiliary material, coating agent, and the weight proportion of mentioned component is 30-80 part, 15-50 part, 5-20 part.Described composite organic acid is citric acid, fumaric acid, malic acid, lactic acid, linoleic acid, crataegolic acid, ursolic acid, chlorogenic acid, glycyrrhizic acid, oleanolic acid, and auxiliary material is silica, hydroxypropyl methylcellulose, ethyl cellulose.Acidulant of the present invention has proportioning science; effect is strong; long-acting slow-release; do not destroy feed Middle nutrition material, good fluidity, easily mix with feed, can promote that nutrient digestion absorbs; improve food conversion ratio; improve livestock and poultry production performance, effectively shorten marketing time, the gastrointestinal tract mucous health that watches for animals, enhancing Immune Function In Animals, prevent disease.
Description
Technical field
The invention belongs to feed and additive technology field, be specifically related to a kind of slowly-releasing compound acidulant for animal and fowl fodder, its preparation method and the feed containing it.
Background technology
Acidulant is the material that can make feed acidifying, increase the immature Enteron Acidity of children livestock and poultry in age.The sixties in 20th century brings into use acidulant, and main purpose controls grice diarrhoea.Piglet digestive system development is immature, and gastric acid output is low, lacks free hydrochloric acid.Lactose in breast milk can be converted into lactic acid by lactic acid bacteria in stomach by suckling pig, makes up the shortcoming of acid.And weanling pig is due to the transformation of feed resource, in addition gastric acid secretion deficiency and lactose supply sharply decline, gastric juice pH is caused to rise, not only weaken the sterilizing ability of gastric juice, also limit activity and the gastrointestinal motor function of pipe intestinal digesting enzyme, have impact on the absorption of nutritional labeling, have impact on growing of piglet.
Along with going deep into of research, increasing research both at home and abroad shows, uses acidulant to reduce intestines and stomach pH value, not only can regulate and control gastrointestinol microorganism colony balance, suppresses pernicious bacteria breeding, reduces the consumption of nutriment and bacteriotoxic generation; Promote the propagation of beneficial bacterium simultaneously, suppress or kill harmful flora, reduce the generation of the diseases such as diarrhoea; Digestive enzyme activity and the rate of digestion of daily ration can also be improved, promote that nutritional labeling absorbs, improve animal daily gain, reduce meat feed ratio; Also can participate in internal metabolism directly, promote the absorption of nutriment; Seasoning effect can also be played, stimulating animal oral cavity taste buds cell, salivary secretion increased thus increases appetite, improving animal feed intake.Therefore acidulant is particularly important, and is more and more paid close attention to and generally use, and its range of application expands to other animal productiong from piglet, and acidulant has become the class feed addictive occupying critical role.
Acidulant is divided into single acidulant and the large class of compound acidulant two, and single acidulant comprises inorganic acid and organic acid.Inorganic acid conventional in feed has hydrochloric acid, phosphoric acid etc., and organic acid has lactic acid, citric acid, propionic acid, malic acid etc.; Compound acidulant is the product be composited by a certain percentage by acidulant not of the same race.Currently more unanimously think that effect puts in order preferably and be: Compound-acid > organic acid > inorganic acid.Although compound acidulant is effective, but its mode played a role is still play limited effect by the mode of acidifying reduction pH value, the effect such as its growth promotion, seasoning, raising feed intake is fair, but the less effective of immunity of preventing and curing diseases, improve, can not play the due effect of acidulant completely.
At present, preparation method's mainly simple physical mixing of acidulant, granulating, this preparation method easily makes acidulant expose, and the acidulant of this exposure not only destroys other nutritional labelings in feed, affect the palatability of feed, even in process, corrode feed processing machinery; In addition, the acidulant used at present is easily neutralized by alkali, loses acidization; Emission and absorption is too fast under one's belt, reflectivity gastric acid secretion inhibiting, affects the normal development of stomach function; The acid added cannot arrive small intestine, effectively can not reduce the pH value in small intestine, can not reach the object suppressing harmful microorganism growth, promote beneficial bacterium growth; The easy generation moisture absorption or cause the feed caking that makes moist rotten etc.Occurred that use cellulose acetate-phthalate and Arabic gum carry out coating, use the preparation method such as beta-schardinger dextrin-and stearic acid microencapsulation in recent years, but preparation method is still immature, cannot really be applied in industry.
The acid ingredient extracted in Chinese medicine is the effective active composition being separated from Chinese medicine, concentrating, there is stronger anti-bacteria and anti-virus, improve the functions such as immunity, promoting blood circulation and removing blood stasis, liver protecting, removing toxic substances, in acidulant, add the acid ingredient extracted in Chinese medicine can work in coordination with the effect strengthening resisting pathogenic microbes, improve immunity, accuse of clearer and more definite, curative effect is more directly with definite.The compound acidulant that existing acidulant and probio (Chinese patent: application number 200510024539.1) form, there is not yet the combination of extract component in acidulant and Chinese medicine.
In sum, acidulant uses in a large number in aquaculture, and acidulant and preparation thereof also exist problems and deficiency, and therefore, further strengthening research Development of New Generation acidulant product is imperative.
Summary of the invention
In order to solve the problem, the invention provides a kind of slowly-releasing compound acidulant for animal and fowl fodder, its preparation method and the feed containing it.
Slowly-releasing compound acidulant for animal and fowl fodder provided by the invention, comprises the component of following weight parts: composite organic acid 30-80 part, auxiliary material 15-50 part and coating agent 5-20 part; Described composite organic acid comprises the component of following weight parts: citric acid 1-30 part, fumaric acid 5-40 part, malic acid 1-20 part, lactic acid 5-30 part, linoleic acid 0.5-5 part, crataegolic acid 1-20 part, ursolic acid 1-20 part, chlorogenic acid 1-20 part, glycyrrhizic acid 1-20 part and oleanolic acid 1-10 part; Described auxiliary material comprises the component of following weight parts: silica 50-80 part, hydroxypropyl methylcellulose 10-30 part and ethyl cellulose 10-30 part; Described coating agent is the agent of enteric solubility sustained release coating and/or the agent of stomach dissolution type sustained release coating.
In a preferred embodiment, the slowly-releasing compound acidulant of animal and fowl fodder of the present invention comprises the component of following weight parts: composite organic acid 40-70 part, auxiliary material 20-40 part and coating agent 10-20 part; Described composite organic acid comprises the component of following weight parts: citric acid 5-30 part, fumaric acid 10-30 part, malic acid 5-20 part, lactic acid 5-20 part, linoleic acid 0.5-3 part, crataegolic acid 5-20 part, ursolic acid 5-20 part, chlorogenic acid 5-20 part, glycyrrhizic acid 5-20 part and oleanolic acid 2-10 part; Described auxiliary material comprises the component of following weight parts: silica 50-70 part, hydroxypropyl methylcellulose 15-25 part and ethyl cellulose 15-25 part.
In a further preferred embodiment, the slowly-releasing compound acidulant of animal and fowl fodder of the present invention comprises the component of following weight parts: composite organic acid 50-60 part, auxiliary material 30-40 part and coating agent 10-15 part; Described composite organic acid comprises the component of following weight parts: citric acid 10-20 part, fumaric acid 10-20 part, malic acid 5-10 part, lactic acid 10-20 part, linoleic acid 1-2 part, crataegolic acid 5-15 part, ursolic acid 5-15 part, chlorogenic acid 5-15 part, glycyrrhizic acid 5-15 part and oleanolic acid 5-10 part; Described auxiliary material comprises the component of following weight parts: silica 60-70 part, hydroxypropyl methylcellulose 15-20 part and ethyl cellulose 15-20 part.
In the present invention, the enteric solubility sustained release coating agent be applicable to can be and well known to a person skilled in the art the agent of any enteric solubility sustained release coating, is preferably No. II, polyacrylic resin; The stomach dissolution type sustained release coating agent be applicable to can be and well known to a person skilled in the art the agent of any stomach dissolution type sustained release coating, is preferably No. IV, polyacrylic resin.
In the present invention, crataegolic acid, ursolic acid, chlorogenic acid, glycyrrhizic acid and oleanolic acid are the acidic materials extracted from Chinese medicine, all can commercially availablely buy, and content should be greater than 98%.
The present invention also provides a kind of method preparing described slowly-releasing compound acidulant, and it comprises the steps:
1) each component is taken respectively by weight;
2) with silica absorption lactic acid and linoleic acid, other component is pulverized, crosses 100 mesh sieves, by povidone solution by raw material softwood, extrude, round as a ball, granulate, dry, sieve, get 18 ~ 24 order micropills, obtain acidulant particle;
3) in fluidizing fluid-bed, by step 2) part enteric solubility sustained release coating agent in the acidulant particle prepared carries out dressing; Dressing is carried out in the agent of remainder stomach dissolution type sustained release coating;
4) by step 3) acidulant particle after the dressing prepared mixes, to obtain final product.
The present invention also provides the described application of slowly-releasing compound acidulant in feed addictive.
Slowly-releasing compound acidulant of the present invention can join in feed, is prepared into the feed comprising this slowly-releasing compound acidulant.The addition of described slowly-releasing compound acidulant is preferably feed per ton and adds 0.5-1kg slowly-releasing compound acidulant.
The present invention has following beneficial effect:
1) acidulant proportioning science of the present invention, effect is definite, and effect is strong;
2) acidulant of the present invention can promote that nutrient digestion absorbs, and improves food conversion ratio, and improves livestock and poultry production performance, effectively shortens marketing time, the gastrointestinal tract mucous health that watches for animals, enhancing Immune Function In Animals, prevent disease;
3) acidulant of the present invention has long-acting slow-release feature, achieve the release of acidulant multisection type slowly-releasing, ensure that acidulant all can play a role at intestines and stomach, not only play a role under one's belt, also the pH value in small intestine can effectively be reduced, improve intestinal microbial balance, thus suppress harmful microorganism growth in small intestine, the growth of promotion beneficial bacterium, and efficiency time is long;
4) feature that the acidulant that prepared by the inventive method has the not easily moisture absorption, do not affect palatability, do not corrode manufacturing and processing equipment, do not destroy other nutritional labelings in feed;
5) acidulant of the present invention avoids current antibiotic and chemical antibacterials abuse and the problem such as the medicament residue that brings and drug resistance generation thereof, ensures animal food safety and Environmental security;
6) acidulant of the present invention adopts modern technology preparation, constant product quality, controlled, has the stronger market competitiveness.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.
Embodiment 1
1) raw material containing following weight is taken:
Citric acid 0.8kg, fumaric acid 4kg, malic acid 0.8kg, lactic acid 4kg, linoleic acid 0.4kg, crataegolic acid 16kg, ursolic acid 16kg, chlorogenic acid 16kg, glycyrrhizic acid 16kg, oleanolic acid 6kg, silica 7.5kg, hydroxypropyl methylcellulose 4.5kg, ethyl cellulose 3kg, polyacrylic resin IV 2.5kg, polyacrylic resin II 2.5kg, add up to 100kg.
2) with silica absorption lactic acid and linoleic acid, other raw material is pulverized, crosses 100 mesh sieves, by appropriate povidone solution by raw material softwood, extrude, round as a ball, granulate, dry, sieve, get 18 ~ 24 order micropills, obtain acidulant particle;
3) be placed in fluidizing fluid-bed, by step 2) No. IV, polyacrylic resin dissolving of half 95% ethanol in the acidulant particle prepared carries out dressing; Remaining half No. II, the polyacrylic resin that 95% ethanol dissolves carries out dressing;
4) by step 3) acidulant particle after the dressing prepared mixes, to obtain final product.
Embodiment 2
1) raw material containing following weight is taken:
Citric acid 8kg, fumaric acid 32kg, malic acid 8kg, lactic acid 24kg, linoleic acid 4kg, crataegolic acid 0.8kg, ursolic acid 0.8kg, chlorogenic acid 0.8kg, glycyrrhizic acid 0.8kg, oleanolic acid 0.8kg, silica 1 2kg, hydroxypropyl methylcellulose 1.5kg, ethyl cellulose 1.5kg, polyacrylic resin IV 2.5kg, polyacrylic resin II 2.5kg, add up to 100kg.
2) with silica absorption lactic acid and linoleic acid, other raw material is pulverized, crosses 100 mesh sieves, by appropriate povidone solution by raw material softwood, extrude, round as a ball, granulate, dry, sieve, get 18 ~ 24 order micropills, obtain acidulant particle;
3) be placed in fluidizing fluid-bed, by step 2) No. IV, polyacrylic resin dissolving of half 95% ethanol in the acidulant particle prepared carries out dressing; Remaining half No. II, the polyacrylic resin that 95% ethanol dissolves carries out dressing;
4) by step 3) acidulant particle after the dressing prepared mixes, to obtain final product.
Embodiment 3
1) raw material containing following weight is taken:
Citric acid 5kg, fumaric acid 12kg, malic acid 5kg, lactic acid 5kg, linoleic acid 1.5kg, crataegolic acid 0.3kg, ursolic acid 0.3kg, chlorogenic acid 0.3kg, glycyrrhizic acid 0.3kg, oleanolic acid 0.3kg, silica 40kg, hydroxypropyl methylcellulose 5kg, ethyl cellulose 5kg, polyacrylic resin IV 10kg, polyacrylic resin II 10kg, add up to 100kg.
2) with silica absorption lactic acid and linoleic acid, other raw material is pulverized, crosses 100 mesh sieves, by appropriate povidone solution by raw material softwood, extrude, round as a ball, granulate, dry, sieve, get 18 ~ 24 order micropills, obtain acidulant particle;
3) be placed in fluidizing fluid-bed, by step 2) No. IV, polyacrylic resin dissolving of half 95% ethanol in the acidulant particle prepared carries out dressing; Remaining half No. II, the polyacrylic resin that 95% ethanol dissolves carries out dressing;
4) by step 3) acidulant particle after the dressing prepared mixes, to obtain final product.
Embodiment 4
1) raw material containing following weight is taken:
Citric acid 0.3kg, fumaric acid 1.5kg, malic acid 0.3kg, lactic acid 1.5kg, linoleic acid 0.15kg, crataegolic acid 6kg, ursolic acid 6kg, chlorogenic acid 6kg, glycyrrhizic acid 6kg, oleanolic acid 2.25kg, silica 25kg, hydroxypropyl methylcellulose 15kg, ethyl cellulose 10kg, polyacrylic resin IV 10kg, polyacrylic resin II 10kg, add up to 100kg.
2) with silica absorption lactic acid and linoleic acid, other raw material is pulverized, crosses 100 mesh sieves, by appropriate povidone solution by raw material softwood, extrude, round as a ball, granulate, dry, sieve, get 18 ~ 24 order micropills, obtain acidulant particle;
3) be placed in fluidizing fluid-bed, by step 2) No. IV, polyacrylic resin dissolving of half 95% ethanol in the acidulant particle prepared carries out dressing; Remaining half No. II, the polyacrylic resin that 95% ethanol dissolves carries out dressing;
4) by step 3) acidulant particle after the dressing prepared mixes, to obtain final product.
Embodiment 5
1) raw material containing following weight is taken:
Citric acid 21kg, fumaric acid 10kg, malic acid 9.25kg, lactic acid 14kg, linoleic acid 0.35kg, crataegolic acid 3.5kg, ursolic acid 3.5kg, chlorogenic acid 3.5kg, glycyrrhizic acid 3.5kg, oleanolic acid 1.4kg, silica 1 4kg, hydroxypropyl methylcellulose 3kg, ethyl cellulose 3kg, polyacrylic resin IV 5kg, polyacrylic resin II 5kg, add up to 100kg.
2) with silica absorption lactic acid and linoleic acid, other raw material is pulverized, crosses 100 mesh sieves, by appropriate povidone solution by raw material softwood, extrude, round as a ball, granulate, dry, sieve, get 18 ~ 24 order micropills, obtain acidulant particle;
3) be placed in fluidizing fluid-bed, by step 2) No. IV, polyacrylic resin dissolving of half 95% ethanol in the acidulant particle prepared carries out dressing; Remaining half No. II, the polyacrylic resin that 95% ethanol dissolves carries out dressing;
4) by step 3) acidulant particle after the dressing prepared mixes, to obtain final product.
Embodiment 6
1) raw material containing following weight is taken:
Citric acid 3.5kg, fumaric acid 7kg, malic acid 3.5kg, lactic acid 3.5kg, linoleic acid 0.35kg, crataegolic acid 10kg, ursolic acid 10kg, chlorogenic acid 14kg, glycyrrhizic acid 14kg, oleanolic acid 4.15kg, silica 1 0kg, hydroxypropyl methylcellulose 5kg, ethyl cellulose 5kg, polyacrylic resin IV 5kg, polyacrylic resin II 5kg, add up to 100kg.
2) with silica absorption lactic acid and linoleic acid, other raw material is pulverized, crosses 100 mesh sieves, by appropriate povidone solution by raw material softwood, extrude, round as a ball, granulate, dry, sieve, get 18 ~ 24 order micropills, obtain acidulant particle;
3) be placed in fluidizing fluid-bed, by step 2) No. IV, polyacrylic resin dissolving of half 95% ethanol in the acidulant particle prepared carries out dressing; Remaining half No. II, the polyacrylic resin that 95% ethanol dissolves carries out dressing;
4) by step 3) acidulant particle after the dressing prepared mixes, to obtain final product.
Embodiment 7
1) raw material containing following weight is taken:
Citric acid 8kg, fumaric acid 12kg, malic acid 2kg, lactic acid 8kg, linoleic acid 1.2kg, crataegolic acid 2kg, ursolic acid 2kg, chlorogenic acid 2kg, glycyrrhizic acid 2kg, oleanolic acid 0.8kg, silica 28kg, hydroxypropyl methylcellulose 6kg, ethyl cellulose 6kg, polyacrylic resin IV 10kg, polyacrylic resin II 10kg, add up to 100kg.
2) with silica absorption lactic acid and linoleic acid, other raw material is pulverized, crosses 100 mesh sieves, by appropriate povidone solution by raw material softwood, extrude, round as a ball, granulate, dry, sieve, get 18 ~ 24 order micropills, obtain acidulant particle;
3) be placed in fluidizing fluid-bed, by step 2) No. IV, polyacrylic resin dissolving of half 95% ethanol in the acidulant particle prepared carries out dressing; Remaining half No. II, the polyacrylic resin that 95% ethanol dissolves carries out dressing;
4) by step 3) acidulant particle after the dressing prepared mixes, to obtain final product.
Embodiment 8
1) raw material containing following weight is taken:
Citric acid 2kg, fumaric acid 4kg, malic acid 2kg, lactic acid 2kg, linoleic acid 0.2kg, crataegolic acid 6kg, ursolic acid 6kg, chlorogenic acid 8kg, glycyrrhizic acid 6kg, oleanolic acid 3.8kg, silica 20kg, hydroxypropyl methylcellulose 10kg, ethyl cellulose 10kg, polyacrylic resin IV 10kg, polyacrylic resin II 10kg, add up to 100kg.
2) with silica absorption lactic acid and linoleic acid, other raw material is pulverized, crosses 100 mesh sieves, by appropriate povidone solution by raw material softwood, extrude, round as a ball, granulate, dry, sieve, get 18 ~ 24 order micropills, obtain acidulant particle;
3) be placed in fluidizing fluid-bed, by step 2) No. IV, polyacrylic resin dissolving of half 95% ethanol in the acidulant particle prepared carries out dressing; Remaining half No. II, the polyacrylic resin that 95% ethanol dissolves carries out dressing;
4) by step 3) acidulant particle after the dressing prepared mixes, to obtain final product.
Embodiment 9
1) raw material containing following weight is taken:
Citric acid 10kg, fumaric acid 10kg, malic acid 5kg, lactic acid 10kg, linoleic acid 1kg, crataegolic acid 2.5kg, ursolic acid 2.5kg, chlorogenic acid 2.5kg, glycyrrhizic acid 2.5kg, oleanolic acid 4kg, silica 28kg, hydroxypropyl methylcellulose 6kg, ethyl cellulose 6kg, polyacrylic resin IV 5kg, polyacrylic resin II 5kg, add up to 100kg.
2) with silica absorption lactic acid and linoleic acid, other raw material is pulverized, crosses 100 mesh sieves, by appropriate povidone solution by raw material softwood, extrude, round as a ball, granulate, dry, sieve, get 18 ~ 24 order micropills, obtain acidulant particle;
3) be placed in fluidizing fluid-bed, by step 2) No. IV, polyacrylic resin dissolving of half 95% ethanol in the acidulant particle prepared carries out dressing; Remaining half No. II, the polyacrylic resin that 95% ethanol dissolves carries out dressing;
4) by step 3) acidulant particle after the dressing prepared mixes, to obtain final product.
Embodiment 10
1) raw material containing following weight is taken:
Citric acid 5kg, fumaric acid 5kg, malic acid 2.5kg, lactic acid 5kg, linoleic acid 0.5kg, crataegolic acid 7.5kg, ursolic acid 7kg, chlorogenic acid 7.5kg, glycyrrhizic acid 5kg, oleanolic acid 5kg, silica 28kg, hydroxypropyl methylcellulose 6kg, ethyl cellulose 6kg, polyacrylic resin IV 5kg, polyacrylic resin II 5kg, add up to 100kg.
2) with silica absorption lactic acid and linoleic acid, other raw material is pulverized, crosses 100 mesh sieves, by appropriate povidone solution by raw material softwood, extrude, round as a ball, granulate, dry, sieve, get 18 ~ 24 order micropills, obtain acidulant particle;
3) be placed in fluidizing fluid-bed, by step 2) No. IV, polyacrylic resin dissolving of half 95% ethanol in the acidulant particle prepared carries out dressing; Remaining half No. II, the polyacrylic resin that 95% ethanol dissolves carries out dressing;
4) by step 3) acidulant particle after the dressing prepared mixes, to obtain final product.
Embodiment 11
1) raw material containing following weight is taken:
Citric acid 12kg, fumaric acid 12kg, malic acid 6kg, lactic acid 12kg, linoleic acid 1kg, crataegolic acid 3kg, ursolic acid 3kg, chlorogenic acid 5kg, glycyrrhizic acid 3kg, oleanolic acid 3kg, silica 21kg, hydroxypropyl methylcellulose 4.5kg, ethyl cellulose 4.5kg, polyacrylic resin IV 5kg, polyacrylic resin II 5kg, add up to 100kg.
2) with silica absorption lactic acid and linoleic acid, other raw material is pulverized, crosses 100 mesh sieves, by appropriate povidone solution by raw material softwood, extrude, round as a ball, granulate, dry, sieve, get 18 ~ 24 order micropills, obtain acidulant particle;
3) be placed in fluidizing fluid-bed, by step 2) No. IV, polyacrylic resin dissolving of half 95% ethanol in the acidulant particle prepared carries out dressing; Remaining half No. II, the polyacrylic resin that 95% ethanol dissolves carries out dressing;
4) by step 3) acidulant particle after the dressing prepared mixes, to obtain final product.
Embodiment 12
1) raw material containing following weight is taken:
Citric acid 6kg, fumaric acid 6kg, malic acid 3kg, lactic acid 6kg, linoleic acid 0.6kg, crataegolic acid 9kg, ursolic acid 8kg, chlorogenic acid 9kg, glycyrrhizic acid 8kg, oleanolic acid 4.4kg, silica 1 8kg, hydroxypropyl methylcellulose 6kg, ethyl cellulose 6kg, polyacrylic resin IV 5kg, polyacrylic resin II 5kg, add up to 100kg.
2) with silica absorption lactic acid and linoleic acid, other raw material is pulverized, crosses 100 mesh sieves, by appropriate povidone solution by raw material softwood, extrude, round as a ball, granulate, dry, sieve, get 18 ~ 24 order micropills, obtain acidulant particle;
3) be placed in fluidizing fluid-bed, by step 2) No. IV, polyacrylic resin dissolving of half 95% ethanol in the acidulant particle prepared carries out dressing; Remaining half No. II, the polyacrylic resin that 95% ethanol dissolves carries out dressing;
4) by step 3) acidulant particle after the dressing prepared mixes, to obtain final product.
Embodiment 13
1) raw material containing following weight is taken:
Citric acid 11kg, fumaric acid 11kg, malic acid 5.5kg, lactic acid 11kg, linoleic acid 1kg, crataegolic acid 2.75kg, ursolic acid 2.75kg, chlorogenic acid 4.5kg, glycyrrhizic acid 2.75kg, oleanolic acid 2.75kg, silica 24.5kg, hydroxypropyl methylcellulose 5.25kg, ethyl cellulose 5.25kg, polyacrylic resin IV 5kg, polyacrylic resin II 5kg, add up to 100kg.
2) with silica absorption lactic acid and linoleic acid, other raw material is pulverized, crosses 100 mesh sieves, by appropriate povidone solution by raw material softwood, extrude, round as a ball, granulate, dry, sieve, get 18 ~ 24 order micropills, obtain acidulant particle;
3) be placed in fluidizing fluid-bed, by step 2) No. IV, polyacrylic resin dissolving of half 95% ethanol in the acidulant particle prepared carries out dressing; Remaining half No. II, the polyacrylic resin that 95% ethanol dissolves carries out dressing;
4) by step 3) acidulant particle after the dressing prepared mixes, to obtain final product.
Embodiment 14
1) raw material containing following weight is taken:
Citric acid 5.5kg, fumaric acid 5.5kg, malic acid 2.75kg, lactic acid 5.5kg, linoleic acid 1kg, crataegolic acid 8.25kg, ursolic acid 8.25kg, chlorogenic acid 8.25kg, glycyrrhizic acid 6kg, oleanolic acid 4kg, silica 24.5kg, hydroxypropyl methylcellulose 5.25kg, ethyl cellulose 5.25kg, polyacrylic resin IV 5kg, polyacrylic resin II 5kg, add up to 100kg.
2) with silica absorption lactic acid and linoleic acid, other raw material is pulverized, crosses 100 mesh sieves, by appropriate povidone solution by raw material softwood, extrude, round as a ball, granulate, dry, sieve, get 18 ~ 24 order micropills, obtain acidulant particle;
3) be placed in fluidizing fluid-bed, by step 2) No. IV, polyacrylic resin dissolving of half 95% ethanol in the acidulant particle prepared carries out dressing; Remaining half No. II, the polyacrylic resin that 95% ethanol dissolves carries out dressing;
4) by step 3) acidulant particle after the dressing prepared mixes, to obtain final product.
Embodiment 15
1) raw material containing following weight is taken:
Citric acid 7.5kg, fumaric acid 7.5kg, malic acid 3.5kg, lactic acid 7.5kg, linoleic acid 1kg, crataegolic acid 5kg, ursolic acid 5kg, chlorogenic acid 5kg, glycyrrhizic acid 5kg, oleanolic acid 3kg, silica 24.5kg, hydroxypropyl methylcellulose 5.25kg, ethyl cellulose 5.25kg, polyacrylic resin IV 7.5kg, polyacrylic resin II 7.5kg, add up to 100kg.
2) with silica absorption lactic acid and linoleic acid, other raw material is pulverized, crosses 100 mesh sieves, by appropriate povidone solution by raw material softwood, extrude, round as a ball, granulate, dry, sieve, get 18 ~ 24 order micropills, obtain acidulant particle;
3) be placed in fluidizing fluid-bed, by step 2) No. IV, polyacrylic resin dissolving of half 95% ethanol in the acidulant particle prepared carries out dressing; Remaining half No. II, the polyacrylic resin that 95% ethanol dissolves carries out dressing;
4) by step 3) acidulant particle after the dressing prepared mixes, to obtain final product.
Embodiment 16
1) raw material containing following weight is taken:
Citric acid 5kg, fumaric acid 10kg, malic acid 3kg, lactic acid 10kg, linoleic acid 1kg, crataegolic acid 4kg, ursolic acid 5kg, chlorogenic acid 5kg, glycyrrhizic acid 4kg, oleanolic acid 3kg, silica 21kg, hydroxypropyl methylcellulose 7kg, ethyl cellulose 7kg, polyacrylic resin IV 7.5kg, polyacrylic resin II 7.5kg, add up to 100kg.
2) with silica absorption lactic acid and linoleic acid, other raw material is pulverized, crosses 100 mesh sieves, by appropriate povidone solution by raw material softwood, extrude, round as a ball, granulate, dry, sieve, get 18 ~ 24 order micropills, obtain acidulant particle;
3) be placed in fluidizing fluid-bed, by step 2) No. IV, polyacrylic resin dissolving of half 95% ethanol in the acidulant particle prepared carries out dressing; Remaining half No. II, the polyacrylic resin that 95% ethanol dissolves carries out dressing;
4) by step 3) acidulant particle after the dressing prepared mixes, to obtain final product.
Embodiment 1
1. experimental design
Select 21 age in days weanling pig 120, be divided into 3 groups at random, often group arranges 4 repetitions, each repetition 10 piglets.Use complete feed, free choice feeding and drinking-water, gravity-flow ventilation.1st group, add 1 kilogram of embodiment of the present invention 1 by feed per ton and to feed piglet; 2nd group, add 3 kilograms of common complex organic acidifiers by feed per ton, common complex organic acidifier is prepared from (lower same) through physical mixed by 8% citric acid, 10% fumaric acid, 5% malic acid, 15% lactic acid and silica; 3rd group, be blank group, only give complete feed.Feed continuously 4 weeks, record is searched for food situation and health condition, measures production performance index, and record initial weight, end are heavily etc.
Daily ingestion amount: precise and record weighing amount in advance, clout amount, calculates the average daily ingestion amount of every piglet.
Daily gain: test and empty stomach is carried out to piglet weigh at 21 ages in days, 49 ages in days, calculate the average daily gain of every piglet.
Daily gain=(end weight-initial weight)/test number of days
Feed efficiency: the feed efficiency calculating all stage according to average daily ingestion amount and average daily gain.
Feed efficiency=average daily ingestion amount/average daily gain
2. result of the test
Acidulant affects result of the test in table 1 to weaned piglets.
Table 1 acidulant is on the impact of weaned piglets
| 1st group | 2nd group | 3rd group | |
| Daily ingestion amount (kg) | 0.436±0.018 a | 0.437±0.027 a | 0.403±0.006 b |
| Daily gain (kg) | 0.426±0.014 a | 0.390±0.022 b | 0.325±0.021 c |
| Feed efficiency (F/G) | 1.023±0.008 a | 1.120±0.031 b | 1.243±0.071 c |
A, b significant difference (P < 0.05); A, c difference extremely significantly (P < 0.01); B, c difference extremely significantly (P < 0.01)
3. analyze and conclusion
Result of the test shows, acidulant of the present invention and common complex organic acidifier all have good growth promoting function, but the more common complex organic acidifier of acidulant of the present invention better effects if in growth promotion.
Embodiment 2
1. test objective
Measure the stripping quantity of acidulant of the present invention in simulated gastric fluid, simulated intestinal fluid.
2. test method
Test parameters sets:
Motor speed---100r/min
Dissolution medium temperature---37 DEG C ± 0.5 DEG C
Dissolution medium volume---900ml
Test sample quality 10g
Dissolution medium
Simulated gastric fluid (get hydrochloric acid 3.8376ml, add water about 800ml and pepsin 10g, is diluted with water into 1000ml, gets 900ml for subsequent use).
(pH6.8 phosphate solution---get potassium dihydrogen phosphate 6.8g, the 500ml that adds water makes dissolving to simulated intestinal fluid, regulates pH to 6.8 with 0.1mol/L sodium hydroxide solution; Separately get pancreatin 10g, add water and make dissolving in right amount, after two liquid mixing, be diluted with water to 1000ml, get 900ml for subsequent use).
Test procedure:
Regulate bottom blade apart from inner bottom of beaker portion 25mm ± 2mm;
Ultrasonic 10 minutes of dissolution medium is degassed;
Dissolution medium is heated, and constant in 37 DEG C ± 0.5 DEG C;
Adjusting rotary speed, steadily, gets the 10g embodiment of the present invention 2 sample, adds in tested simulated gastric fluid, timing 6 hours.Take off and turn basket, content crosses 40 mesh sieves, rinses particle surface with water, dry, weighs.
Adjusting rotary speed, steadily, gets the 10g embodiment of the present invention 2 sample, adds in tested simulated intestinal fluid, timing 6 hours.Take off and turn basket, content crosses 40 mesh sieves, rinses particle surface with water, dry, weighs.
3. result of the test
Acidulant dissolution results is in table 2.
Table 2 acidulant dissolution results
| Numbering | Simulated gastric fluid | Simulated intestinal fluid |
| Residue particle weighs (g) | 5.43 | 5.02 |
| Stripping quantity | 4.57 | 4.98 |
| Dissolution rate | 45.7％ | 49.8％ |
4. analyze and conclusion
Result of the test shows, acidulant of the present invention can in stomach, intestines segmentation slow releasing, namely can play a role at stomach, enteron aisle respectively, determined curative effect.
Embodiment 3
1. experimental design
Select milking sow 40, be divided into 4 groups at random, often organize 10, use complete feed, free choice feeding and drinking-water, gravity-flow ventilation.1st group, be blank group, only give complete feed, not acid adding agent.2nd group, add 3 kilograms of common complex organic acidifiers by feed per ton; 3rd group, add 1 kilogram of embodiment of the present invention 3 by feed per ton and to feed piglet; 4th group, add 1 kilogram of embodiment of the present invention 10 by feed per ton and to feed piglet; To feed continuously 4 thoughtful wean to sow, observe the yellowish-white dysentery incidence of weanling pig pig and the death rate.
Diarrhea rate (%)=grice diarrhoea head/piglet head number × test number of days
The dead head number/piglet head number of the death rate (%)=piglet
2. result of the test
The prophylactic tria of acidulant to piglet yellow-white dysentery the results are shown in Table 3.
Table 3 acidulant is to the prophylactic tria of piglet yellow-white dysentery
| 1st group | 2nd group | 3rd group | 4th group | |
| Piglet head number | 102 | 111 | 108 | 126 |
| Grice diarrhoea head | 291 | 164 | 16 | 0 |
| The dead head number of piglet | 6 | 4 | 0 | 0 |
| Diarrhea rate (%) | 10.2％ | 5.3％ | 0.5％ | 0 |
| The death rate (%) | 5.9％ | 3.6％ | 0 | 0 |
3. analyze and conclusion
Result of the test shows, by feeding to milking sow, acidulant of the present invention can effectively prevent the generation of piglet yellow-white dysentery and reduce the piglet death rate, and effect, it is preferred that the embodiment of the present invention 10, is secondly the embodiment of the present invention 3.Acidulant effect of the present invention is all better than common acids agent.
Test example 4
1, experimental design
Select 1 aa broiler chicken 1500, be divided into 5 groups at random, often organize 300 broiler chicken.Use complete feed, free choice feeding and drinking-water, gravity-flow ventilation, the feeding and management of each group is consistent with immune programme for children.1st group, add 1 kilogram of embodiment of the present invention 4 by feed per ton; 2nd group, add 1 kilogram of embodiment of the present invention 7 by feed per ton; 3rd group, add 1 kilogram of embodiment of the present invention 11 by feed per ton; 4th group, add 3 kilograms of common complex organic acidifiers by feed per ton; 5th group, be blank group, only give complete feed.Whole process is fed, and record is searched for food situation and health condition, measures production performance index, and record initial weight, end are heavily etc.
2, result of the test
Acidulant affects result of the test in table 4 to meat chicken production performance.
Table 4 acidulant is on the impact of meat chicken production performance
| 1st group | 2nd group | 3rd group | 4th group | 5th group | |
| Survival rate (%) | 96.6％ | 97.3％ | 99.5％ | 93.2％ | 90.4％ |
| Feedstuff-meat ratio | 2.11 | 2.04 | 1.98 | 2.23 | 2.40 |
3, analysis and conclusion
Result of the test shows, acidulant embodiment 4 of the present invention, embodiment 7, embodiment 11 are all better than common complex organic acidifier and control group in survival rate, feedstuff-meat ratio etc., effect, it is preferred that the embodiment of the present invention 11, is secondly the embodiment of the present invention 7, is finally the embodiment of the present invention 4.Therefore acidulant of the present invention can promote growth of meat chicken, improves the price of deed, uses acidulant of the present invention can obtain better economic benefit.
Test example 5
1. experimental design
Select 1 aa broiler chicken 90, be divided into 3 groups at random, often organize 30.Use complete feed, free choice feeding and drinking-water, gravity-flow ventilation, the feeding and management of each group is consistent with immune programme for children.1st group, add 1 kilogram of embodiment of the present invention 5 by feed per ton and to feed piglet; 2nd group, add 3 kilograms of common complex organic acidifiers by feed per ton; 3rd group, be blank group, only give complete feed.Whole process is fed, and butchers at the 50th day, wins spleen, the bursa of farbricius, both sides thymus gland, claims its fresh weight, respectively divided by live-weight, be expressed as a percentage, be index and spleen index, bursal index and thymus index.
2. result of the test
Acidulant affects result of the test in table 5 to broiler chicken immune organ.
Table 5 acidulant is on the impact of broiler chicken immune organ
| 1st group | 2nd group | 3rd group | |
| Index and spleen index (%) | 0.24 | 0.19 | 0.16 |
| Bursal index (%) | 0.42 | 0.35 | 0.32 |
| Thymus index (%) | 0.76 | 0.65 | 0.59 |
3. analyze and conclusion
Result of the test shows, acidulant of the present invention is compared with control group with common complex organic acidifier, can significantly improve index and spleen index, bursal index, thymus index, and therefore acidulant of the present invention can promote animal immune allelotaxis, improves immunity.
Test example 6
1. experimental design
Select farrowing sow 96, be divided into 4 groups at random, often organize 24, use complete feed, free choice feeding and drinking-water, gravity-flow ventilation.1st group, be blank group, only give complete feed, not acid adding agent.2nd group, add 3 kilograms of common complex organic acidifiers by feed per ton; 3rd group, add 1 kilogram of embodiment of the present invention 6 by feed per ton and to feed piglet; 4th group, add 1 kilogram of embodiment of the present invention 14 by feed per ton and to feed piglet; Feed continuously to childbirth in whole period of pregnancy, a situation arises and prevention of sow constipation situation to observe sow triad in postpartum.
2. result of the test
Acidulant affects result of the test in table 6 to sow triad and prevention of sow constipation.
Table 6 acidulant is on the impact of sow triad and prevention of sow constipation
| 1st group | 2nd group | 3rd group | 4th group | |
| triad incidence | 33.3% | 25% | 0 | 0 |
| constipation incidence | 41.6% | 20.8% | 4.2% | 0 |
3. analyze and conclusion
Result of the test shows, can prevent sow triad in postpartum to farrowing sow acidulant of the present invention of feeding, and reduce the generation of prevention of sow constipation, effect, it is preferred that the embodiment of the present invention 14, is secondly the embodiment of the present invention 6.Acidulant effect of the present invention is all better than common acids agent.
Test example 7
1. experimental design
Select 28 age in days weanling pig 80, be divided into 4 groups at random, often organize 20, use complete feed, free choice feeding and drinking-water, gravity-flow ventilation.1st group, be blank group, only give complete feed, not acid adding agent.2nd group, add 3 kilograms of common complex organic acidifiers by feed per ton; 3rd group, add 1 kilogram of embodiment of the present invention 8 by feed per ton and to feed piglet; 4th group, add 1 kilogram of embodiment of the present invention 9 by feed per ton and to feed piglet; Feed continuously 2 weeks, under aseptic condition, take out Stomach duodenum, ileum, jejunal content, measure pH value.
2. result of the test
Acidulant affects result of the test in table 7 to piglet digestive pH value.
Table 7 acidulant is on the impact of piglet digestive pH value
| 1st group | 2nd group | 3rd group | 4th group | |
| Stomach | 4.24 | 3.09 | 2.34 | 2.12 |
| Duodenum | 6.85 | 6.32 | 5.45 | 5.06 |
| Ileum | 6.97 | 6.56 | 5.88 | 5.52 |
| Jejunum | 7.15 | 6.87 | 6.31 | 6.02 |
3. analyze and conclusion
Result of the test shows, acidulant embodiment 8 of the present invention and embodiment 9 all just can effectively reduce piglet digestive pH value at the comparatively low dosage recommended, and can arrive enteron aisle and play a role, and acting on the strongest is the embodiment of the present invention 9, is secondly the embodiment of the present invention 8.The more common complex organic acidifier of acidulant of the present invention all shows stronger effect.
Test example 8
1. experimental design
Cold season in severe winter, make insulation and ventilate to take into account.Be incubated and ventilated freely, caused ammonia concentration to raise, cause pig easily breathing problem to occur, and growth retardation.The weanling pig 580 on certain pig farm is divided into two groups by this test, A group 290, B group 290, and A group is added 1 kilogram of the present embodiment 12, B group by feed per ton and added 3 kilograms of common complex organic acidifiers by feed per ton; Feed continuously 4 weeks, observe pig growing state and breathing problem incidence.
2. result of the test
Acidulant on the impact of severe winter pig growing state in table 8.
Table 8 acidulant is on the impact of severe winter pig growing state
| A group | B group | |
| Daily gain (kilogram) | 0.401 | 0.285 |
| Breathing problem incidence | 0.23％ | 23.12％ |
3. analyze and conclusion
Result of the test shows, after using acidulant of the present invention, in pig house, ammonia is significantly less than and uses common complex organic acidifier group, effectively reduces the incidence of breathing problem, improves production performance.Therefore acidulant of the present invention comparatively common acids agent there is better effect.
Test example 9
1. experimental design
Select 28 age in days weanling pig 120, be divided into 4 groups at random, often group arranges 3 repetitions, each repetition 10 piglets.Use complete feed, free choice feeding and drinking-water, gravity-flow ventilation.1st group, add 1 kilogram of embodiment of the present invention 13 by feed per ton and to feed piglet; 2nd group, add 0.5 kilogram of embodiment of the present invention 13 by feed per ton and to feed piglet; 3rd group, add 3 kilograms of common complex organic acidifiers by feed per ton; 4th group, be blank group, only give complete feed.Feed continuously 4 weeks, observe diarrhoea situation and the death rate.
2. result of the test
Acidulant affects result of the test in table 9 to grice diarrhoea rate and the death rate.
Table 9 acidulant is on the impact of grice diarrhoea rate and the death rate
| 1st group | 2nd group | 3rd group | 4th group | |
| Diarrhea rate % | 0.00±0.00 a | 0.71±0.36 a | 5.48±1.25 b | 9.76±1.61 b |
| Death rate % | 0.00±0.00 | 0.00±0.00 | 3.33±5.77 | 6.67±5.77 |
A, b significant difference (P < 0.01)
3. analyze and conclusion
Result of the test shows, compared with common complex organic acidifier, no matter adds 0.5 kilogram or adding 1 kilogram all has better prevention effect to grice diarrhoea, and effectively can reduce the death rate of piglet in acidulant of the present invention one ton of feed.0.5-1 kilogram of acidulant of the present invention can be added according to feed per ton to use in production practices.
Test example 10
1. experimental design
Select the weanling pig 90 suffering from diarrhoea, be divided into 3 groups at random, often organize 30, use complete feed, free choice feeding and drinking-water, gravity-flow ventilation.1st group, only give 10% retens soluble powder and treat, not acid adding agent.2nd group, while use 10% retens soluble powder carries out treating, add 3 kilograms of common complex organic acidifiers by feed per ton; 3rd group, while use 10% retens soluble powder carries out treating, add 1 kilogram of embodiment of the present invention 15 by feed per ton and to feed piglet; Observe grice diarrhoea treatment situation.
2. result of the test
Acidulant to grice diarrhoea adjuvant treatment effect in table 10.
Table 10 acidulant is to grice diarrhoea adjuvant treatment effect
| 1st group | 2nd group | 3rd group | |
| Suffer from yellowish-white dysentery piglet head number | 30 | 30 | 30 |
| Cure head number | 24 | 28 | 30 |
| Cure rate | 80.0％ | 93 .3％ | 100％ |
3. analyze and conclusion
Result of the test shows, giving acidulant at use antibiotic therapy grice diarrhoea can improve cure rate simultaneously, better than being used alone effects of antibiotics, and the synergistic effect of acidulant of the present invention is obviously better than common acids agent.
Test example 11
1. experimental design
Sweltering heat stress often can cause pig to be fallen ill or death as one, 1080 head growths on certain pig farm are fattened pig and are divided into two groups by this test, A group 600, B group 480, A group is added 0.5 kilogram of the present embodiment 16, B group by feed per ton and is added 3 kilograms of common complex organic acidifiers by feed per ton; Feed continuously whole summer, observation hot climate in summer is on the impact of pig.
2. result of the test
Acidulant to heat stress preventive effect in table 11.
Table 11 acidulant is to heat stress preventive effect
| A group | B group | |
| Survival rate | 99.8％ | 95.6％ |
| The incidence of disease | 1.87％ | 10.96％ |
3. analyze and conclusion
Result of the test shows, acidulant of the present invention has higher survival rate under hot climate, and effectively reduces the incidence of disease, and comparatively common acids agent has better anti-heat stress effect.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (8)
1. for a slowly-releasing compound acidulant for animal and fowl fodder, it is characterized in that, comprise the component of following weight parts: composite organic acid 30-80 part, auxiliary material 15-50 part and coating agent 5-20 part; Described composite organic acid comprises the component of following weight parts: citric acid 1-30 part, fumaric acid 5-40 part, malic acid 1-20 part, lactic acid 5-30 part, linoleic acid 0.5-5 part, crataegolic acid 1-20 part, ursolic acid 1-20 part, chlorogenic acid 1-20 part, glycyrrhizic acid 1-20 part and oleanolic acid 1-10 part; Described auxiliary material comprises the component of following weight parts: silica 50-80 part, hydroxypropyl methylcellulose 10-30 part and ethyl cellulose 10-30 part; Described coating agent is the agent of enteric solubility sustained release coating and the agent of stomach dissolution type sustained release coating.
2. slowly-releasing compound acidulant according to claim 1, is characterized in that, comprises the component of following weight parts: composite organic acid 40-70 part, auxiliary material 20-40 part and coating agent 10-20 part; Described composite organic acid comprises the component of following weight parts: citric acid 5-30 part, fumaric acid 10-30 part, malic acid 5-20 part, lactic acid 5-20 part, linoleic acid 0.5-3 part, crataegolic acid 5-20 part, ursolic acid 5-20 part, chlorogenic acid 5-20 part, glycyrrhizic acid 5-20 part and oleanolic acid 2-10 part; Described auxiliary material comprises the component of following weight parts: silica 50-70 part, hydroxypropyl methylcellulose 15-25 part and ethyl cellulose 15-25 part.
3. slowly-releasing compound acidulant according to claim 2, is characterized in that, comprises the component of following weight parts: composite organic acid 50-60 part, auxiliary material 30-40 part and coating agent 10-15 part; Described composite organic acid comprises the component of following weight parts: citric acid 10-20 part, fumaric acid 10-20 part, malic acid 5-10 part, lactic acid 10-20 part, linoleic acid 1-2 part, crataegolic acid 5-15 part, ursolic acid 5-15 part, chlorogenic acid 5-15 part, glycyrrhizic acid 5-15 part and oleanolic acid 5-10 part; Described auxiliary material comprises the component of following weight parts: silica 60-70 part, hydroxypropyl methylcellulose 15-20 part and ethyl cellulose 15-20 part.
4. the slowly-releasing compound acidulant described in any one of claim 1-3, is characterized in that, described enteric solubility sustained release coating agent is acrylic acid resinⅡ, and described stomach dissolution type sustained release coating agent is polyacrylate resin.
5. the preparation method of the slowly-releasing compound acidulant described in any one of claim 1-4, it comprises the steps:
1) each component is taken respectively by weight;
2) with silica absorption lactic acid and linoleic acid, other component is pulverized, crosses 100 mesh sieves, by povidone solution by raw material softwood, extrude, round as a ball, granulate, dry, sieve, get 18 ~ 24 order micropills, obtain acidulant particle;
3) in fluidizing fluid-bed, by step 2) part enteric solubility sustained release coating agent in the acidulant particle prepared carries out dressing; Dressing is carried out in the agent of remainder stomach dissolution type sustained release coating;
4) by step 3) acidulant particle after the dressing prepared mixes, to obtain final product.
6. the application of slowly-releasing compound acidulant in feed addictive described in any one of claim 1-4.
7. the feed containing the slowly-releasing compound acidulant described in any one of claim 1-4.
8. feed according to claim 7, is characterized in that, the addition of described slowly-releasing compound acidulant is 0.5-1kg/ ton feed.
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