CN102870987B - Green feed additive used for improving development of intestinal canal of infant animal - Google Patents
Green feed additive used for improving development of intestinal canal of infant animal Download PDFInfo
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- 241001465754 Metazoa Species 0.000 title abstract description 43
- 230000000968 intestinal effect Effects 0.000 title abstract description 11
- 235000013406 prebiotics Nutrition 0.000 claims abstract description 40
- 150000007524 organic acids Chemical class 0.000 claims abstract description 39
- 239000000654 additive Substances 0.000 claims abstract description 4
- 230000000996 additive effect Effects 0.000 claims abstract description 4
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- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 24
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- PVXPPJIGRGXGCY-TZLCEDOOSA-N 6-O-alpha-D-glucopyranosyl-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)C(O)(CO)O1 PVXPPJIGRGXGCY-TZLCEDOOSA-N 0.000 claims description 8
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Abstract
The invention discloses a green feed additive used for improving the development of intestinal canal of an infant animal. The additive comprises prebiotics, probiotics, organic acid and a proper amount of carrier, realizes rational proportion of prebiotics, probiotics and organic acid, can effectively improve various adverse physical symptoms caused by imperfect development of gastrointestinal digestive system of the infant animal, particularly reduces diarrhea incidence, and also can improve the feed conversion rate and promote growth and development of animals at the same time. The green feed additive provided by the invention can replace antibiotics, improves safety of animal products, and reduces medicine residue.
Description
Technical field
The present invention relates to feed additive field, particularly a kind of for improving the green feed additive of young animal intestinal growth.
Background technology
Young animal is due to the flip-flop that is subject to physiology, nutrition and environment, add physiological development immature, especially the imperfection of gut development, easily cause various bad reactions and disease, cause animal immunizing power low, very easily give the growing of animal, the later stage grows up and breeding causes harmful effect, and easily mass-sends epidemic disease, give to produce and cause heavy losses.
The intestines and stomach of young animal are the main place of digesting and assimilating nutrient, and its Intestinal Mucosal Immunity is again the immune important component part of young animal simultaneously, and the healthy growth that maintains young animal is had to important function.Because the gut development of young animal is still far from perfect, variation to external factor is more responsive, the change of external environment easily causes stress effect, the change of feed shape simultaneously also easily causes the destruction of intestinal mucosa, and then cause the digestibility of nutrient to reduce, immunologic function descends, and also can cause the change of archenteric flora, has had a strong impact on growing of young animal.Therefore, carry out fair supply young animal enteral nutrition by the feed addictive that adds various trophism and non-nutritive, be conducive to improve digestive tract environment, promote the young animal intestinal growth, maintain normal configuration and the function of enteron aisle, thereby guarantee the health of young animal, give full play to its production performance.This tool that grows for young animal is of great significance.Due to antibiotic residual and the side effects such as bacterial drug resistance that bring thereof, European Union has enacted a law in 2006 and has completely forbidden antibiotic as animal feed additive.So, find antibiotic substitute and become more and more important.
Prebiotics, probio and organic acid three combine use, can effectively make up the incomplete defect of young animal digestive system development, promote reaching maturity rapidly of its gastro-intestinal digestion system, guarantee the good growth of young animal.
Prebiotics mainly refers to various oligosaccharide kind materials, the functional oligosaccharide of especially not digested and assimilated by the animal intestines and stomach.These oligosaccharides substances enter the alimentary canal rear portions such as small intestine rear portion, caecum, coton and rectal smoothly, and a large amount of microorganisms that at these position parasitisms can secrete various glycosidases with these functional oligosaccharide of digestibility and utilization.Large quantity research shows, add prebiotics in feed, not only can promote formation, the breeding of healthy microorganism species in the animal body enteron aisle, but also can in conjunction with, absorb exogenous pathogen, play the effect of regulating body immune system simultaneously, thereby improve the health status of animal body, strengthen the ability of the potential resist the disease of body, and then reach the purpose that improves breeding performonce fo animals.
Probio is well known already as a kind of green feed additive, it is for the young animal feed, can not yet set up in good intestinal microflora situation and help to maintain the microecosystem balance in its body at young animal on the one hand, thereby increase its Abwehrkraft des Koepers; Probio can stimulate the growth of the digestive systems such as young animal intestines and stomach and non-specific immune function on the other hand; Probio also can partly substitute antibacterials simultaneously, by help, recovers the purpose that the animal intestinal microecological balance reaches the treatment Animal diseases.
Organic acid is widely used acidulant in feed at present, can reduce the GI pH value of young animal on the one hand, helps digest and absorbs the nutriments such as protein, amino acid, the growing of promotion enteron aisle and body; The gastrointestinal tract environment that the pH value is lower on the other hand is conducive to beneficial microorganism growth in enteron aisle, and suppresses the growth of the pathogenic microorganisms such as Escherichia coli, salmonella, thereby effectively maintains the animal gastrointestinal tract colony balance, promotes the growth of animal gastrointestinal tract.
But, at present in prebiotics, probio, the application of organic acid as feed addictive, remain in following problem: the research be used in conjunction with between the different oligosaccharides to prebiotics is less; The bacterial classification of probio is single, lacks compatibility and uses; The effect of combining use between prebiotics, probio and organic acid has unstability etc.
Summary of the invention
The object of the invention is to overcome existing deficiency, provide a kind of for improving the green feed additive of young animal intestinal growth.
The technical solution used in the present invention is:
A kind of green feed additive, be comprised of prebiotics, probio, organic acid and appropriate carrier, and wherein prebiotics, probio, organic acid mass ratio are 1: (0.5 ~ 1): (0.5 ~ 1).
Above-mentioned prebiotics is comprised of the component of following mass parts: 10 parts of manna oligosacchrides, 0 ~ 2 part of mannan oligosaccharide, 0 ~ 2 part of galactomannan-oligosaccharide, 1 ~ 5 part of trehalose, 1 ~ 2 part of FOS, 1 ~ 2 part of wood oligose, 1 ~ 2 part of isomaltulose, 1 ~ 2 part of chitosan oligosaccharide.
Above-mentioned probio is comprised of the component of following mass parts: 5 parts of fermentation lactobacillus, 0 ~ 2 part of lactobacillus gasseri, 0 ~ 2 part of lactobacillus acidophilus, 1 ~ 2 part of bacillus subtilis.
Preferably, probio is powder formulation, and the viable count of the pure bacterium powder of each bacterial strain is not less than 1 * 10
10cfu/g.
Above-mentioned organic acid is comprised of the component of following mass parts: 5 parts of fumaric acid, 1 ~ 2 part of lactic acid, 1 ~ 2 part of citric acid.
Preferably, described organic acid is carried out to the microencapsulation embedding treatment.
More excellent, prebiotics is comprised of the component of following mass parts: 10 parts of manna oligosacchrides, 0 ~ 2 part of mannan oligosaccharide, 0 ~ 2 part of galactomannan-oligosaccharide, 1 ~ 5 part of trehalose, 1 ~ 2 part of FOS, 1 ~ 2 part of wood oligose, 1 ~ 2 part of isomaltulose, 1 ~ 2 part of chitosan oligosaccharide; Probio is comprised of the component of following mass parts: 5 parts of fermentation lactobacillus, 0 ~ 2 part of lactobacillus gasseri, 0 ~ 2 part of lactobacillus acidophilus, 1 ~ 2 part of bacillus subtilis; Organic acid is comprised of the component of following mass parts: 5 parts of fumaric acid, 1 ~ 2 part of lactic acid, 1 ~ 2 part of citric acid; By above-mentioned prebiotics, probio, organic acid and the appropriate composite green feed additive that obtains of carrier.
The mixture that above-mentioned carrier is stone flour and maize cob meal, its mass ratio is 1: (1 ~ 3).
The invention has the beneficial effects as follows:
Green feed additive of the present invention has been realized prebiotics, probio and organic acid rational proportion, can effectively improve the various bad physiological signs that young animal causes due to gastro-intestinal digestion systematic growth imperfection, especially reduce Incidence of Diarrhea, also can improve food conversion ratio simultaneously, promote animal growth; Green feed additive of the present invention can the substitute antibiotics series products, improves the security of animal product, reduces medicament residue.
The specific embodiment
The present invention is for improving the green feed additive of young animal intestinal growth, by prebiotics, probio, organic acid and carrier, by rational proportion, formed, prebiotics, probio and organic acid physiological activity have effectively been brought into play, three's combination has simultaneously also formed good synergistic function, thereby promote the intestinal growth of young animal, strengthen immunity and the premunition of young animal.
This additive is 1 by mass ratio: (0.5 ~ 1): the prebiotics of (0.5 ~ 1), probio, organic acid and appropriate carrier are formulated.
Above-mentioned prebiotics is by manna oligosacchride (mannan-oligosaccharides), mannan oligosaccharide (glucomanno-oligosaccharides), galactomannan-oligosaccharide (galactomannan-oligosaccharides), trehalose (trehalose), FOS (fructo-oligosaccharides), wood oligose (xylo-oligosaccharides), the complex prebiotics that isomaltulose (isomalto-oligosaccharides) and chitosan oligosaccharide (chito-oligosaccharide) form, the mass parts of each component is as follows: 10 parts of manna oligosacchrides, 0 ~ 2 part of mannan oligosaccharide, 0 ~ 2 part of galactomannan-oligosaccharide, 1 ~ 5 part of trehalose, 1 ~ 2 part of FOS, 1 ~ 2 part of wood oligose, 1 ~ 2 part of isomaltulose, 1 ~ 2 part of chitosan oligosaccharide, in order to guarantee better effect of the present invention, above-mentioned oligosaccharides should be powder formulation, and in every kind of oligosaccharides raw material, corresponding oligosaccharide content should >=95%.
Above-mentioned probio is comprised of fermentation lactobacillus (Lactobacillus fermentum CGMCC No.0843), lactobacillus gasseri (Lactobacillus gasseri CECT5714), lactobacillus acidophilus (Lactobacillus acidophilus ATCC 4356) and bacillus subtilis (Bacillus subtilis UTM 126), and the mass parts of each component is as follows: 5 parts of fermentation lactobacillus, 0 ~ 2 part of lactobacillus gasseri, 0 ~ 2 part of lactobacillus acidophilus, 1 ~ 2 part of bacillus subtilis; In order to guarantee better effect of the present invention, above-mentioned probio should be powder formulation, and the pure bacterium powder viable count of every kind of bacterial strain should be not less than 1 * 10
10cfu/g.
The composite organic acid that above-mentioned organic acid is comprised of fumaric acid, lactic acid and citric acid, the mass parts of each component is as follows: 5 parts of fumaric acid, 1 ~ 2 part of lactic acid, 1 ~ 2 part of citric acid; In order to guarantee that organic acid can enter the animal alimentary canal rear portion better, and reduce the impact on the probio in said preparation, above-mentioned organic acid all should carry out the microencapsulation embedding treatment.
The mixture that above-mentioned carrier is stone flour and maize cob meal, and the mass ratio of stone flour and maize cob meal is 1: 1 ~ 3;
The addition of this additive can make an addition in the young animal complete diet pellet in 0.05% ~ 0.1% ratio of feed gross weight.
Green feed additive of the present invention is that a kind of being applied to improved the green feed additive that animal intestinal is grown, and is particularly useful for young animal.
Below in conjunction with embodiment, further set forth the present invention.
embodiment 1
Prebiotics is comprised of the component of following mass parts: 10 parts of manna oligosacchrides, 2 parts of trehaloses, 1 part of FOS, 1 part of wood oligose, 2 parts of isomaltuloses, 2 parts of chitosan oligosaccharides; Probio is comprised of the component of following mass parts: 5 parts of fermentation lactobacillus, 1 part of lactobacillus gasseri, 1 part of lactobacillus acidophilus, 1 part of bacillus subtilis; Organic acid is comprised of the component of following mass parts: 5 parts of fumaric acid, 2 parts of lactic acid, 1 part of citric acid; Stone flour and maize cob meal that carrier is 1:3 by mass ratio form; By above-mentioned prebiotics, probio, organic acid and carrier by 1: 1: 0.5: the composite green feed additive that obtains of 5 mass ratio.
Choose 30 ages in days, health, body weight without the Du * length of significant difference * 40 of Dasanyuan hybridization piglets, be divided at random 2 groups, each 20 of test group and control groups, No. 551 compound feed for piglets that control group adopts certain company to produce are fed, and test group is used No. 551 feeds of the above-mentioned green feed additive that has added 0.1%.Test to 60 age in days.Two groups adopt identical feeding and management technology, conventional benefit iron, benefit selenium and inoculation.
Measure piglet body weight on an empty stomach in test initial sum deadline, record feed intake, calculate daily gain and efficiency of feed utilization.Observed and recorded overall process grice diarrhoea situation, calculate diarrhea rate.Result of the test is as shown in table 1:
As can be seen from Table 1, after adding this green feed additive, the pig average daily gain improves 11.6%, and feed conversion rate improves 7.0%, and the grice diarrhoea rate descends 37.5%.
In following examples, if without specified otherwise, all material umbers are mass parts.
embodiment 2
Prebiotics is comprised of following component: 10 parts of manna oligosacchrides, 1 part of mannan oligosaccharide, 1 part of galactomannan-oligosaccharide, 1 part of trehalose, 1 part of FOS, 1 part of wood oligose, 1 part of isomaltulose, 1 part of chitosan oligosaccharide; Probio is comprised of following component: 5 parts of fermentation lactobacillus, 1 part of lactobacillus gasseri, 1 part of lactobacillus acidophilus, 2 parts of bacillus subtilises; Organic acid is comprised of following component: 5 parts of fumaric acid, 1 part of lactic acid, 1 part of citric acid; Stone flour and maize cob meal that carrier is 1:1 by mass ratio form; By above-mentioned prebiotics, probio, organic acid and carrier by 1: 0.5: 0.5: the composite green feed additive that obtains of 8 mass ratio.
Choose the AA meat chick of 120 1 age in days health, be divided at random 2 groups, every group of 3 repetitions, each repeats 20, male and female half and half, and two groups of test chicken body weight are without significant difference.The control group fed basal diet, test group is used the same basic daily ration of the above-mentioned green feed additive added 0.05%.21 days experimental periods.Two groups adopt identical feeding and management technology, and carry out the routine immunization injection.
Respectively at test 21d food 12h of last curfew, in ﹕ 00 weighing chicken empty stomach body weight in mornings 8 next day.Accurate recording chicken feed intake and death condition, calculate average daily gain and death rate.Result of the test is as shown in table 2:
As can be seen from Table 2, after adding this green feed additive, the chicken average daily gain improves 7.7%, and death rate descends 51.2%.
embodiment 3
Prebiotics is comprised of following component: 10 parts of manna oligosacchrides, 2 parts of galactomannan-oligosaccharides, 2 parts of trehaloses, 1 part of FOS, 2 parts of wood oligoses, 2 parts of isomaltuloses, 2 parts of chitosan oligosaccharides; Probio is comprised of following component: 5 parts of fermentation lactobacillus, 1 part of lactobacillus gasseri, 1 part of lactobacillus acidophilus, 1 part of bacillus subtilis; Organic acid is comprised of following component: 5 parts of fumaric acid, 2 parts of lactic acid, 2 parts of citric acids; Stone flour and maize cob meal that carrier is 1:2 by mass ratio form; By above-mentioned prebiotics, probio, organic acid and carrier by 1: 1: 1: the composite green feed additive that obtains of 5 mass ratio.
This green feed additive is made an addition in feed to 23 of the piglets of the laxativeness of feeding in 0.1% ratio, 19 grice diarrhoea sx↓s after 3 days, within 1 week, rear 17 piglets recover normal.
embodiment 4
Prebiotics is comprised of following component: 10 parts of manna oligosacchrides, 1 part of mannan oligosaccharide, 2 parts of trehaloses, 1 part of FOS, 2 parts of wood oligoses, 2 parts of isomaltuloses, 1 part of chitosan oligosaccharide; Probio is comprised of following component: 5 parts of fermentation lactobacillus, 1 part of lactobacillus acidophilus, 1 part of bacillus subtilis; Organic acid is comprised of following component: 5 parts of fumaric acid, 2 parts of lactic acid, 2 parts of citric acids; Stone flour and maize cob meal that carrier is 1:3 by mass ratio form; By above-mentioned prebiotics, probio, organic acid and carrier by 1: 1: 1: the composite green feed additive that obtains of 5 mass ratio.
Choose 3 monthly ages sharp praise * Luxi Yellow cattle of the wood catalo of 32 health, be divided at random 2 groups, every group of 2 repetitions, each repeats 8, and two groups of test calf body weight are without significant difference.Control group fed conventional daily ration, test group is used the identical conventional daily ration of the above-mentioned green feed additive that has added 0.1%.90 days experimental periods.Two groups adopt identical feeding and management technology.
Duration of test, feed for 00 minute three times every day in 8 ﹕ 00,13 ﹕ 30 and 20 ﹕, accurate recording feeding capacity and surplus material amount before and after feeding every day, examination ox free choice feeding, drinking-water, respectively examination Niu Jinhang is weighed in continuous two days on an empty stomach before and after test, get the body weight of its mean value as the examination ox.Calculate average daily gain and efficiency of feed utilization.Result of the test is as shown in table 3:
As can be seen from Table 3, after adding this green feed additive, the calf average daily gain improves 7.6%.
embodiment 5
Prebiotics is comprised of following component: 10 parts of manna oligosacchrides, 1 part of mannan oligosaccharide, 1 part of galactomannan-oligosaccharide, 1 part of trehalose, 1 part of FOS, 2 parts of wood oligoses, 2 parts of isomaltuloses, 2 parts of chitosan oligosaccharides; Probio is comprised of following component: 5 parts of fermentation lactobacillus, 1 part of lactobacillus gasseri, 2 parts of lactobacillus acidophilus, 1 part of bacillus subtilis; Organic acid is comprised of following component: 5 parts of fumaric acid, 2 parts of lactic acid, 2 parts of citric acids; Stone flour and maize cob meal that carrier is 1:1 by mass ratio form; By above-mentioned prebiotics, probio, organic acid and carrier by 1: 1: 1: the composite green feed additive that obtains of 4 mass ratio.
Choose 30 ages in days, health, body weight without 80 of the Du Luoke piglets of significant difference, be divided at random 4 groups, every group 20, the compound feed for piglets that control group fed company produces is fed, test group 1,2 and 3 has increased respectively the above-mentioned green feed additive of prebiotics product that certain company produces, antibiotic and 0.1% on the basis of control group, and test is to 60 ages in days.Three groups adopt identical feeding and management technology.
Measure piglet body weight on an empty stomach respectively at test initial sum deadline, record feed intake, calculate daily gain and efficiency of feed utilization.Observed and recorded is raised omnidistance grice diarrhoea situation, calculates diarrhea rate.Result of the test is as shown in table 4:
As can be seen from Table 4, add the test group of this green feed additive, compare with control group, the pig average daily gain improves 11.2%, and feed conversion rate improves 8.5%, and the grice diarrhoea rate descends 60.0%; With the test group of adding the prebiotics product, compare, the pig average daily gain improves 7.6%, feed conversion rate improves 5.8%, the grice diarrhoea rate descends 33.3%, as can be seen here, the effect by prebiotics, probio, compound this green feed additive obtained of organic acid three is better than single prebiotics product; With the antibiotic group, compare without significant difference, therefore can the substitute antibiotics product;
embodiment 6
Prebiotics is comprised of following component: 10 parts of manna oligosacchrides, 2 parts of mannan oligosaccharides, 5 parts of trehaloses, 2 parts of FOSs, 1 part of wood oligose, 1 part of isomaltulose, 1 part of chitosan oligosaccharide; Probio is comprised of following component: 5 parts of fermentation lactobacillus, 2 parts of lactobacillus gasseris, 2 parts of bacillus subtilises; Organic acid is comprised of following component: 5 parts of fumaric acid, 2 parts of lactic acid, 2 parts of citric acids; Stone flour and maize cob meal that carrier is 1:2 by mass ratio form; By above-mentioned prebiotics, probio, organic acid and carrier by 1: 0.5: 0.5: the composite green feed additive that obtains of 10 mass ratio.
Choose 30 ages in days, health, body weight without the Du * length of significant difference * 48 of Dasanyuan hybridization piglets, be divided at random 2 groups, every group of two repetitions, each repeats 12, the compound feed for piglets that control group fed company produces is fed, test group increases by 0.1% above-mentioned green feed additive on the basis of control group, and test is to 60 ages in days.Two groups adopt identical feeding and management technology.
Measure piglet body weight on an empty stomach respectively at test initial sum deadline, record feed intake, calculate daily gain and efficiency of feed utilization.Observed and recorded is raised omnidistance grice diarrhoea situation, calculates diarrhea rate.Result of the test is as shown in table 5:
As can be seen from Table 5, add the test group of this green feed additive, the pig average daily gain improves 11.1%, and feed conversion rate improves 8.4%, and the grice diarrhoea rate descends 62.5%.
Claims (5)
1. a green feed additive, it is characterized in that: described additive is comprised of prebiotics, probio, organic acid and appropriate carrier, and wherein prebiotics, probio, organic acid mass ratio are 1: (0.5 ~ 1): (0.5 ~ 1); Described prebiotics is comprised of the component of following mass parts: 10 parts of manna oligosacchrides, 0 ~ 2 part of mannan oligosaccharide, 0 ~ 2 part of galactomannan-oligosaccharide, 1 ~ 5 part of trehalose, 1 ~ 2 part of FOS, 1 ~ 2 part of wood oligose, 1 ~ 2 part of isomaltulose, 1 ~ 2 part of chitosan oligosaccharide; Described probio is comprised of the component of following mass parts: 5 parts of fermentation lactobacillus, 0 ~ 2 part of lactobacillus gasseri, 0 ~ 2 part of lactobacillus acidophilus, 1 ~ 2 part of bacillus subtilis; Described organic acid is carried out to the microencapsulation embedding treatment.
2. a kind of green feed additive according to claim 1, it is characterized in that: described probio is powder formulation, and the viable count of the pure bacterium powder of each bacterial strain is not less than 1 * 10
10cfu/g.
3. a kind of green feed additive according to claim 1, it is characterized in that: described organic acid is comprised of the component of following mass parts: 5 parts of fumaric acid, 1 ~ 2 part of lactic acid, 1 ~ 2 part of citric acid.
4. a kind of green feed additive according to claim 1, it is characterized in that: prebiotics is comprised of the component of following mass parts: 10 parts of manna oligosacchrides, 0 ~ 2 part of mannan oligosaccharide, 0 ~ 2 part of galactomannan-oligosaccharide, 1 ~ 5 part of trehalose, 1 ~ 2 part of FOS, 1 ~ 2 part of wood oligose, 1 ~ 2 part of isomaltulose, 1 ~ 2 part of chitosan oligosaccharide; Probio is comprised of the component of following mass parts: 5 parts of fermentation lactobacillus, 0 ~ 2 part of lactobacillus gasseri, 0 ~ 2 part of lactobacillus acidophilus, 1 ~ 2 part of bacillus subtilis; Organic acid is comprised of the component of following mass parts: 5 parts of fumaric acid, 1 ~ 2 part of lactic acid, 1 ~ 2 part of citric acid; By above-mentioned prebiotics, probio, organic acid and the appropriate composite green feed additive that obtains of carrier.
5. according to the described a kind of green feed additive of claim 1 or 4, it is characterized in that: the mixture that described carrier is stone flour and maize cob meal, its mass ratio is 1: (1 ~ 3).
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