CN106721247B - Feed additive capable of promoting intestinal development of weaned piglets - Google Patents
Feed additive capable of promoting intestinal development of weaned piglets Download PDFInfo
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/153—Nucleic acids; Hydrolysis products or derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
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Abstract
The invention discloses a feed additive capable of promoting intestinal development of weaned piglets, which comprises the following components in parts by weight: 1-6 parts of prebiotics, 1-6 parts of probiotics and 1-5 parts of nucleotide. The feed additive realizes reasonable proportion of prebiotics, probiotics and nucleotide, can effectively improve the intestinal development of weaned pigs, enhance the immunity and reduce the influence of weaned stress of the piglets on the intestinal metabolism; can reduce diarrhea of weaned piglets, improve survival rate, and replace antibiotics; can improve the feed conversion rate, the economic value and the like. The method has important significance for modern scientific, intensive and large-scale pig raising production.
Description
Technical Field
The invention relates to the field of feed additives, and particularly relates to a feed additive capable of promoting intestinal development of weaned piglets.
Background
The research and application of the feed formula of the early weaned piglets are directly related to the growth of the weaned piglets and the exertion of the production performance in the future. In China, compared with the traditional weaning days of piglets, the weaning days of the piglets are generally called as early weaning at 21-35 days of age, and the weaning before 21 days of age is called as super-early weaning. However, early weaned piglets, especially ultra-early weaned piglets, face the problems of immature digestive tract development, poor gastrointestinal function, incomplete immunity, low disease resistance and the like, and the weaning is also related to the change of physiological, psychological, environmental and nutritional conditions of the piglets, which can cause the piglet allergy, the decrease of feed intake rate, the low utilization rate of feed and the delay of growth and development, thereby seriously affecting the economic benefit of the pig industry.
The combined use of the prebiotics, the probiotics and the nucleotide can effectively make up the defect of incomplete development of the digestive system of the weaned pig, promote the rapid development and maturity of the gastrointestinal digestive system of the weaned pig and ensure the good growth of the weaned pig.
Prebiotics are dietary supplements that beneficially affect the host by selectively stimulating the growth and activity of one or a small number of bacteria in the colony, thereby improving the health of the host. Successful prebiotics are largely undigested and fermented by the gut flora when they pass through the upper gut. Most importantly, it stimulates the growth of beneficial bacterial flora and not harmful bacteria with potentially pathogenic or putrefactive activity.
Probiotics is a kind of active microorganisms beneficial to a host, and is a general term for active beneficial microorganisms which are planted in intestinal tracts and reproductive systems of organisms and can produce exact health effects so as to improve the microbial ecological balance of the host and play beneficial roles.
The demand for nucleotides increases during rapid growth, stress and immunosuppression in animals, and weaned piglets encounter just these conditions, where metabolically vigorous organs and tissues require a large supply of exogenous nucleotides. However, weaned pigs lack the energy and glutamine required for nucleotide synthesis, which causes the shortage of endogenous nucleotides and needs to be supplemented with exogenous nucleotides.
At present, many reports exist on single application of prebiotics, probiotics and nucleotides, but the combined application of the prebiotics, the probiotics and the nucleotides is rarely reported.
Disclosure of Invention
In order to solve the problems in the existing weaned pig feed, the invention provides a feed additive capable of promoting the intestinal development of weaned pigs. The additive is added into daily feed of piglets according to a certain amount, so that the stress reaction of weaning of the piglets can be effectively relieved, and the production performance of the piglets is improved.
In order to solve the technical problems, the invention adopts the following technical scheme:
a feed additive capable of promoting intestinal development of weaned piglets comprises the following components in parts by weight:
1-6 parts of prebiotics,
1-6 parts of probiotics,
1-5 parts of nucleotide.
The additive preferably comprises the following components in parts by weight:
4 parts of prebiotics, namely 4 parts of prebiotics,
6 parts of probiotics, namely 6 parts of probiotics,
and 3 parts of nucleotide.
The prebiotics comprise the following components in parts by weight: 1-3 parts of fructo-oligosaccharide and 1-3 parts of galacto-oligosaccharide, preferably consisting of the following components in parts by weight: 3 parts of fructo-oligosaccharide and 1 part of galacto-oligosaccharide.
The probiotic comprises the following components in parts by weight: 1-3 parts of lactobacillus fermentum and 1-3 parts of bacillus subtilis, and preferably consists of the following components in parts by weight: 3 parts of lactobacillus fermentum and 3 parts of bacillus subtilis.
Wherein the probiotics is a powder preparation, and the viable count of the pure bacterial powder of each strain is not less than 1 x 1010 cfu/g.
Wherein, the nucleotide is prepared by taking ribonucleic acid as a raw material, hydrolyzing by an enzyme method to obtain mixed nucleotide liquid, and directly spraying and drying.
Wherein, the nucleotide comprises the following components in percentage by weight: 50-70% of nucleotide, 5-15% of crude protein, 2-6% of crude fat, 12-25% of ash and 5-9% of water.
Wherein the addition amount of the feed additive in the feed for weaned piglets is 0.05-0.5 wt%, preferably 0.3 wt%.
The application of the feed additive in promoting the intestinal development of weaned piglets is also within the protection scope of the invention.
Has the advantages that: compared with the prior art, the feed additive technology capable of promoting the intestinal development of weaned piglets has the following advantages:
the additive disclosed by the invention is composed of prebiotics, probiotics and nucleotide, and the reasonable proportion of the prebiotics, the probiotics and the nucleotide is realized. The intestinal development of weaned piglets can be effectively improved, the immunity is enhanced, and the influence of weaned stress on intestinal metabolism of the piglets is reduced; can reduce diarrhea of weaned piglets, improve survival rate, and replace antibiotics; can improve the feed conversion rate, the economic value and the like. The method has important significance for modern scientific, intensive and large-scale pig raising production.
Detailed Description
The invention will be better understood from the following examples. However, those skilled in the art will readily appreciate that the description of the embodiments is only for illustrating the present invention and should not be taken as limiting the invention as detailed in the claims.
In the following examples, the probiotic bacteria are powder preparations, and the viable count of the pure bacteria powder of each strain is not less than 1 x 1010 cfu/g. The nucleotide is prepared by using ribonucleic acid as a raw material, performing enzymatic hydrolysis to obtain mixed nucleotide liquid, and directly performing spray drying.
Wherein, the nucleotide comprises the following components in percentage by weight: 50-70% of nucleotide, 5-15% of crude protein, 2-6% of crude fat, 12-25% of ash and 5-9% of water.
Examples 1 to 4
The component proportion of the feed additive is shown in the table 1, and the parts are parts by weight.
TABLE 1
Example 5:
test animals and groups:
300 weaned piglets with similar body weights and about 30 days old are selected and randomly divided into 5 groups according to the initial body weights, namely a control group and a test 1-5 groups. Each group is internally provided with 6 replicates, each replicate is provided with 10 pigs, each treatment is respectively fed with corresponding daily ration, the whole experiment process is free to feed and drink, and the feeding management method is determined according to the specific conditions of the experiment field.
Control group: the basic ration is determined according to the conditions of a test field without changing, and the formula and the nutritional ingredients of the basic ration are shown in a table 2;
test group 1: 0.1 wt% of the feed additive of example 1 was added to the basal diet formulation;
test group 2: 0.1 wt% of the feed additive of example 2 was added to the basal diet formulation;
test group 3: 0.1 wt% of the feed additive of example 3 was added to the basal diet formulation;
test group 4: 0.1 wt% of the feed additive of example 4 was added to the basal diet formulation;
TABLE 2 basic diet formula and nutritional ingredients
1Per kilogram of premix comprises: vitamin a, 16 ten thousand IU; vitamin D, 3.5 ten thousand IU; vitamin E, 550 IU; vitamin K, 45 mg; vitamin B1, 30 mg; vitamin B2, 150 mg; vitamin B6, 20 mg; vitamin B12, 0.4 mg; calcium pantothenate, 100 mg; niacin, 390 mg; folic acid, 20 mg; biotin, 0.2 mg; iron, 3.0 g; copper, 3.6 g; manganese, 0.75 g; 3.0g of zinc; iodine, 35.0 mg; selenium, 7.0 mg; lysine, 3.5%; 8% of salt; 8.0g/kg of choline; 12% of calcium; total phosphorus, 3.0%.
2The complex enzyme product produced by Wuhan Xinhua poplar bio-corporation comprises 1400IU of acid protease, 600IU of neutral protease, 2500IU of amylase, 800IU of xylanase, β -mannase, 3600IU of xylanase, β -glucanase, 200IU of xylanase and 800IU of xylanase per gram.
3The Chongqing Jiamei spice is produced by Chongqing Jiamei spice Co., Ltd, butyric acid is more than or equal to 1%, a Maillard reactant is more than or equal to 5%, and a refined squid extract is more than or equal to 5%.
The fasting body weight of the piglets is measured at the beginning and the end of the test, the feed intake is recorded, and the daily gain and the feed utilization rate are calculated. Observing and recording the diarrhea condition of the piglets in the whole process, and calculating the diarrhea rate. The test results are shown in table 3.
TABLE 3
As can be seen from the above table, the test groups 1, 2, 3 and 4 are prebiotic addition groups, and both the material weight ratio and the diarrhea rate are significantly reduced compared with the control group, wherein the test group 3 has the best effect.
Examples 6 to 9:
the component proportion of the feed additive is shown in the table 4, and the components are in parts by weight.
TABLE 4
Example 10:
test animals and groups:
300 weaned piglets with similar body weights and about 30 days old are selected and randomly divided into 5 groups according to the initial body weights, namely a control group and a test 1-5 groups. Each group is internally provided with 6 replicates, each replicate is provided with 10 pigs, each treatment is respectively fed with corresponding daily ration, the whole experiment process is free to feed and drink, and the feeding management method is determined according to the specific conditions of the experiment field.
Control group: the basic ration is determined according to the conditions of a test field without changing, and the formula and the nutritional ingredients of the basic ration are shown in a table 2;
test group 5: 0.1 wt% of the feed additive of example 6 was added to the basal diet formulation;
test group 6: 0.1 wt% of the feed additive of example 7 was added to the basal diet formulation;
test group 7: 0.1 wt% of the feed additive of example 8 was added to the basal diet formulation;
test group 8: 0.1 wt% of the feed additive of example 9 was added to the basal diet formulation;
the fasting body weight of the piglets is measured at the beginning and the end of the test, the feed intake is recorded, and the daily gain and the feed utilization rate are calculated. Observing and recording the diarrhea condition of the piglets in the whole process, and calculating the diarrhea rate. The test results are shown in table 5:
TABLE 5
As can be seen from the above table, the test groups 5, 6, 7 and 8 are probiotic bacteria-added groups, and both the feed-weight ratio and the diarrhea rate are significantly reduced compared with the control group, wherein the test group 8 has the best effect.
Examples 11 to 14:
the component proportion of the feed additive is shown in the table 6, and the parts are parts by weight.
TABLE 6
Example 15:
test animals and groups:
300 weaned piglets with similar body weights and about 30 days old are selected and randomly divided into 5 groups according to the initial body weights, namely a control group and a test 1-5 groups. Each group is internally provided with 6 replicates, each replicate is provided with 10 pigs, each treatment is respectively fed with corresponding daily ration, the whole experiment process is free to feed and drink, and the feeding management method is determined according to the specific conditions of the experiment field. Control group: the basic ration is determined according to the conditions of a test field without changing, and the formula and the nutritional ingredients of the basic ration are shown in a table 2;
test group 9: 0.2 wt% of the feed additive of example 11 was added to the basal diet formulation;
test group 10: 0.2 wt% of the feed additive of example 12 was added to the basal diet formulation;
test group 11: 0.2 wt% of the feed additive of example 13 was added to the basal diet formulation;
test group 12: 0.2 wt% of the feed additive of example 14 was added to the basal diet formulation;
the fasting body weight of the piglets is measured at the beginning and the end of the test, the feed intake is recorded, and the daily gain and the feed utilization rate are calculated. Observing and recording the diarrhea condition of the piglets in the whole process, and calculating the diarrhea rate. The test results are shown in table 7:
TABLE 7
As can be seen from the above table, the test group 9 is a combination group of prebiotics and probiotics, the test groups 10, 11, and 12 are a combination group of prebiotics, probiotics, and nucleotides, and the test groups 10, 11, and 12 have significantly reduced diarrhea rate compared to the control group and the test group 9, wherein the test group 11 has the best effect.
Example 16:
test animals and groups:
420 weaned piglets with similar body weights and about 30 days old are selected and randomly divided into 7 groups according to the initial body weights, namely a control group and test groups 1-7. Each group is internally provided with 6 replicates, each replicate is provided with 10 pigs, each treatment is respectively fed with corresponding daily ration, the whole experiment process is free to feed and drink, and the feeding management method is determined according to the specific conditions of the experiment field.
Test group 13: 0.05 wt% of the feed additive of example 13 was added to the basal diet formulation;
test group 14: 0.1 wt% of the feed additive of example 13 was added to the basal diet formulation;
test group 15: 0.2 wt% of the feed additive of example 13 was added to the basal diet formulation;
test group 16: 0.3 wt% of the feed additive of example 13 was added to the basal diet formulation;
test group 17: 0.4 wt% of the feed additive of example 23 was added to the basal diet formulation;
test group 18: 0.5 wt% of the feed additive of example 13 was added to the basal diet formulation;
the fasting body weight of the piglets is measured at the beginning and the end of the test, the feed intake is recorded, and the daily gain and the feed utilization rate are calculated. Observing and recording the diarrhea condition of the piglets in the whole process, and calculating the diarrhea rate. The test results are shown below:
as can be seen from the table above, when the total adding amount of the prebiotics, the probiotics and the nucleotide combination is 0.3 wt%, the diarrhea rate is obviously reduced regardless of the material weight ratio.
In conclusion, the optimal formula of the invention is as follows: the prebiotics comprises the following components in parts by mass: 3 parts of fructo-oligosaccharide and 1 part of galacto-oligosaccharide. The probiotic comprises the following components in parts by mass: 3 parts of lactobacillus fermentum and 3 parts of bacillus subtilis. The nucleotide mass component is 3 parts. The total addition amount in the feed is 0.3 wt%.
Claims (2)
1. The feed additive capable of promoting intestinal development of weaned piglets is characterized by comprising the following components in parts by weight:
3 parts of fructo-oligosaccharide;
1 part of galacto-oligosaccharide;
3 parts of lactobacillus fermentum;
3 parts of bacillus subtilis;
1-5 parts of nucleotide;
the lactobacillus fermentum and the bacillus subtilis are powder preparations, and the viable count of the pure bacterial powder of each strain is not less than 1 x 1010cfu/g；
The nucleotide is prepared by taking ribonucleic acid as a raw material, performing enzymatic hydrolysis to obtain mixed nucleotide liquid, and directly performing spray drying;
the nucleotide comprises the following components in percentage by weight: 50-70% of nucleotide, 5-15% of crude protein, 2-6% of crude fat, 12-25% of ash and 5-9% of water.
2. The feed additive for promoting intestinal development of weaned piglets according to claim 1, wherein the feed additive is added to the feed for weaned piglets in an amount of 0.05-0.5 wt%.
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| CN201611039910.6A CN106721247B (en) | 2016-11-10 | 2016-11-10 | Feed additive capable of promoting intestinal development of weaned piglets |
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| CN107307203A (en) * | 2017-06-27 | 2017-11-03 | 淮北佳羊生物科技有限公司 | Weanling pig applicability formula forage |
| CN108338125A (en) * | 2018-02-07 | 2018-07-31 | 张掖市金农源生物科技有限公司 | A kind of breeding pannage and its cultural method |
| CN109770053A (en) * | 2019-01-25 | 2019-05-21 | 华中农业大学 | A kind of mixed fodder additive for early-weaned piglets |
| CA3222748A1 (en) * | 2021-06-21 | 2022-12-29 | Microharvest Gmbh | Extracts from fast growing microbes |
| CN115553385A (en) * | 2021-07-02 | 2023-01-03 | 广州市正百生物科技有限公司 | Feed additive for improving anti-stress capability and immunity of animals, preparation method and feed |
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| CN111513204B (en) | 2023-07-18 |
| CN111513204A (en) | 2020-08-11 |
| CN106721247A (en) | 2017-05-31 |
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