CN111513204B - Application of feed additive in promoting intestinal development of weaned piglets - Google Patents
Application of feed additive in promoting intestinal development of weaned piglets Download PDFInfo
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/153—Nucleic acids; Hydrolysis products or derivatives thereof
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- A—HUMAN NECESSITIES
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- A23K20/00—Accessory food factors for animal feeding-stuffs
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- A23K20/163—Sugars; Polysaccharides
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- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
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Abstract
The invention discloses an application of a feed additive in promoting intestinal development of weaned piglets, which comprises the following components in parts by weight: 1 to 6 parts of prebiotics, 1 to 6 parts of probiotics and 1 to 5 parts of nucleotides. The feed additive realizes reasonable proportion of prebiotics, probiotics and nucleotide, can effectively improve intestinal development of weaned piglets, strengthen immunity and reduce the influence of weaning stress of the piglets on intestinal metabolism; can reduce diarrhea of weaned piglets, improve survival rate, and replace antibiotics; can improve the feed conversion rate, the economic value and the like. The method has important significance for modern scientific, intensive and large-scale pig raising production.
Description
Technical Field
The invention relates to the field of feed additives, in particular to application of a feed additive in promoting intestinal development of weaned piglets.
Background
The research and application of the feed formula for early weaned pigs are directly related to the growth and the future production performance of the weaned pigs. In China, compared with the traditional weaning day age of piglets, weaning of 21-35 days is generally called early weaning, and weaning before 21 days is called super early weaning. However, early weaned piglets, especially super early weaned piglets, face the problems of immature gastrointestinal development, poor gastrointestinal function, insufficient immune function, low disease resistance and the like, weaning is also related to the changes of physiology, psychology, environment and nutrition conditions of the piglets, and the problems can cause allergy of the piglets, reduced feeding rate, low utilization rate of feed and delay of growth and development, so that the economic benefit of the pig industry is seriously influenced.
The combined use of the prebiotics, the probiotics and the nucleotide can effectively make up the defect of imperfect development of the digestive system of the weaned pigs, promote the rapid development and maturation of the gastrointestinal digestive system of the weaned pigs and ensure the good growth of the weaned pigs.
Prebiotics are dietary supplements that beneficially affect the host by selectively stimulating the growth and activity of bacteria in one or a few colonies, thereby improving the health of the host's indigestible food ingredient. Successful prebiotics are fermented by the intestinal flora, mostly undigested, while passing through the upper digestive tract. Most importantly, it is merely stimulating the growth of beneficial flora and not harmful bacteria with potentially pathogenic or spoilage activity.
Probiotics are active microorganisms beneficial to a host, and are general names of active beneficial microorganisms which are fixedly planted in intestinal tracts and reproductive systems of organisms and can generate definite health effects so as to improve the micro-ecological balance of the host and exert beneficial effects.
The need for nucleotides in animals during rapid growth, stress and immunosuppression increases, and weaned pigs experience all of these conditions, and the metabolically vigorous organs and tissues require a large supply of exogenous nucleotides. However, weaned pigs lack the energy and glutamine required for nucleotide synthesis, which results in the deficiency of endogenous nucleotides and the need for exogenous nucleotide supplementation.
At present, a single application of prebiotics, probiotics and nucleotides is reported in a large number, but the combined application of the prebiotics, the probiotics and the nucleotides is rarely reported.
Disclosure of Invention
In order to solve the problems existing in the current weaned piglet feed, the invention provides a feed additive capable of promoting intestinal development of weaned piglets. The additive is added into daily feed of piglets according to a certain amount, so that the stress response of weaning piglets can be effectively relieved, and the production performance of the piglets is improved.
In order to solve the technical problems, the invention adopts the following technical scheme:
a feed additive capable of promoting intestinal development of weaned piglets comprises the following components in parts by weight:
1 to 6 parts of prebiotics,
1 to 6 parts of probiotics,
1-5 parts of nucleotide.
The additive is preferably composed of the following components in parts by weight:
4 parts of prebiotics, namely, a probiotic,
6 parts of probiotics, namely a probiotic and a feed additive,
3 parts of nucleotide.
The prebiotics comprise the following components in parts by weight: 1-3 parts of fructo-oligosaccharide and 1-3 parts of galacto-oligosaccharide, and preferably consists of the following components in parts by weight: 3 parts of fructo-oligosaccharide and 1 part of galacto-oligosaccharide.
The probiotics comprise the following components in parts by weight: 1-3 parts of lactobacillus fermentum and 1-3 parts of bacillus subtilis, and preferably consists of the following components in parts by weight: 3 parts of lactobacillus fermentum and 3 parts of bacillus subtilis.
The probiotics are powder preparations, and the viable count of the pure bacterial powder of each bacterial strain is not less than 1 x 1010cfu/g.
Wherein the nucleotide is obtained by taking ribonucleic acid as a raw material, hydrolyzing by an enzyme method to obtain mixed nucleotide liquid, and directly spraying and drying.
Wherein the nucleotide comprises the following components in percentage by weight: 50-70% of nucleotide, 5-15% of crude protein, 2-6% of crude fat, 12-25% of ash and 5-9% of water.
Wherein the addition amount of the feed additive in the weaned piglet feed is 0.05-0.5wt%, preferably 0.3wt%.
The application of the feed additive in promoting the intestinal development of weaned piglets is also within the protection scope of the invention.
The beneficial effects are that: compared with the prior art, the feed additive technology capable of promoting intestinal development of weaned piglets has the following advantages:
the additive provided by the invention consists of prebiotics, probiotics and nucleotides, so that reasonable proportioning of the prebiotics, the probiotics and the nucleotides is realized. Can effectively improve the intestinal development of weaned piglets, strengthen the immunity and reduce the influence of weaning stress of the piglets on intestinal metabolism; can reduce diarrhea of weaned piglets, improve survival rate, and replace antibiotics; can improve the feed conversion rate, the economic value and the like. The method has important significance for modern scientific, intensive and large-scale pig raising production.
Detailed Description
The invention will be better understood from the following examples. However, it will be readily appreciated by those skilled in the art that the description of the embodiments is provided for illustration only and should not limit the invention as described in detail in the claims.
In the following examples, the probiotics are powder preparations, and the viable count of the pure bacterial powder of each strain is not less than 1 x 1010cfu/g. The nucleotide is obtained by taking ribonucleic acid as a raw material, hydrolyzing by an enzyme method to obtain mixed nucleotide liquid, and directly spraying and drying.
Wherein the nucleotide comprises the following components in percentage by weight: 50-70% of nucleotide, 5-15% of crude protein, 2-6% of crude fat, 12-25% of ash and 5-9% of water.
Examples 1 to 4
The composition ratio of the feed additive is shown in Table 1, and the parts are weight parts.
TABLE 1
Example 5:
test animals and groupings:
300 weaned piglets with similar weight and about 30 days of age are selected and randomly divided into 5 groups according to initial weight, wherein the 5 groups are respectively a control group and a test group 1-5 groups. 6 repeats are arranged in each group, 10 pigs are fed with corresponding daily ration in each treatment, the whole test process freely ingests and drinks, and the feeding management method is determined according to the specific conditions of the test field.
Control group: the basic ration is determined according to the conditions of a test field, the formula and the nutrition components of the basic ration are shown in Table 2;
test group 1: 0.1wt% of the feed additive of example 1 was added to the base ration formula;
test group 2: 0.1wt% of the feed additive of example 2 was added to the base ration formula;
test group 3: 0.1wt% of the feed additive of example 3 was added to the base ration formula;
test group 4: 0.1wt% of the feed additive of example 4 was added to the base ration formula;
table 2 basic ration formula and nutrient composition
1 Each kilogram of premix comprises: vitamin A,16 ten thousand IU; vitamin D,3.5 IU; vitamin E,550IU; vitamin K,45mg; vitamin B1, 30mg; vitamin B2, 150mg; vitamin B6, 20mg; vitamin B12,0.4mg; 100mg of calcium pantothenate; niacin, 390mg; folic acid, 20mg; biotin, 0.2mg; iron, 3.0g; copper, 3.6g; manganese, 0.75g; zinc, 3.0g; iodine, 35.0mg; selenium, 7.0mg; lysine, 3.5%; salt, 8%; choline, 8.0g/kg; calcium, 12%; total phosphorus, 3.0%.
2 Wuhan Xinhua Yang ShengManufactured by the company limited, stock, comprising per gram of complex enzyme product: acid protease, 1400IU; neutral protease, 600IU; amylase, 2500IU; xylanase, 800IU; beta-mannanase, 3600IU; beta-glucanase, 200IU; xylanase, 800IU.
3 Chongqing Jiamei spice Co., ltd, butyric acid is more than or equal to 1%, maillard reactant is more than or equal to 5%, and extract of refined squid is more than or equal to 5%.
The fasting weight of the piglets is measured at the beginning and the ending days of the test, the feed intake is recorded, and the daily gain and the feed utilization rate are calculated. And (5) observing and recording diarrhea conditions of piglets in the whole process, and calculating diarrhea rate. The test results are shown in Table 3.
TABLE 3 Table 3
From the above table, test groups 1,2,3, and 4 were prebiotic addition groups, and the ratio of the feed to the weight and the diarrhea rate were significantly lower than those of the control group, wherein test group 3 had the best effect.
Examples 6 to 9:
the composition ratio of the feed additive is shown in Table 4, and the parts are parts by weight.
TABLE 4 Table 4
Example 10:
test animals and groupings:
300 weaned piglets with similar weight and about 30 days of age are selected and randomly divided into 5 groups according to initial weight, wherein the 5 groups are respectively a control group and a test group 1-5 groups. 6 repeats are arranged in each group, 10 pigs are fed with corresponding daily ration in each treatment, the whole test process freely ingests and drinks, and the feeding management method is determined according to the specific conditions of the test field.
Control group: the basic ration is determined according to the conditions of a test field, the formula and the nutrition components of the basic ration are shown in Table 2;
test group 5: 0.1wt% of the feed additive of example 6 was added to the base ration formula;
test group 6: 0.1wt% of the feed additive of example 7 was added to the base ration formula;
test group 7: 0.1wt% of the feed additive of example 8 was added to the base ration formula;
test group 8: 0.1wt% of the feed additive of example 9 was added to the base ration formula;
the fasting weight of the piglets is measured at the beginning and the ending days of the test, the feed intake is recorded, and the daily gain and the feed utilization rate are calculated. And (5) observing and recording diarrhea conditions of piglets in the whole process, and calculating diarrhea rate. The test results are shown in table 5:
TABLE 5
As can be seen from the above table, test groups 5,6,7,8 are probiotic addition groups, and the ratio of the feed to the feed and the diarrhea rate are obviously reduced compared with the control group, wherein the test group 8 has the best effect.
Examples 11 to 14:
the composition ratio of the feed additive is shown in Table 6, and the parts are weight parts.
TABLE 6
Example 15:
test animals and groupings:
300 weaned piglets with similar weight and about 30 days of age are selected and randomly divided into 5 groups according to initial weight, wherein the 5 groups are respectively a control group and a test group 1-5 groups. 6 repeats are arranged in each group, 10 pigs are fed with corresponding daily ration in each treatment, the whole test process freely ingests and drinks, and the feeding management method is determined according to the specific conditions of the test field. Control group: the basic ration is determined according to the conditions of a test field, the formula and the nutrition components of the basic ration are shown in Table 2;
test group 9: 0.2wt% of the feed additive of example 11 was added to the base ration formula;
test group 10: 0.2wt% of the feed additive of example 12 was added to the base ration formula;
test group 11: 0.2wt% of the feed additive of example 13 was added to the base ration formula;
test group 12: 0.2wt% of the feed additive of example 14 was added to the basal diet formulation;
the fasting weight of the piglets is measured at the beginning and the ending days of the test, the feed intake is recorded, and the daily gain and the feed utilization rate are calculated. And (5) observing and recording diarrhea conditions of piglets in the whole process, and calculating diarrhea rate. The test results are shown in Table 7:
TABLE 7
From the above table, test group 9 is a prebiotic and probiotic combination group, test groups 10, 11, 12 are a prebiotic, probiotic and nucleotide combination group, and test groups 10, 11, 12 have significantly lower feed/weight ratio and diarrhea rate than control group and test group 9, wherein test group 11 has the best effect.
Example 16:
test animals and groupings:
420 weaned piglets with similar weight and about 30 days of age are selected and randomly divided into 7 groups according to initial weight, namely a control group and 1-7 groups of test. 6 repeats are arranged in each group, 10 pigs are fed with corresponding daily ration in each treatment, the whole test process freely ingests and drinks, and the feeding management method is determined according to the specific conditions of the test field.
Test group 13: 0.05wt% of the feed additive of example 13 was added to the base ration formula;
test group 14: 0.1wt% of the feed additive of example 13 was added to the base ration formula;
test group 15: 0.2wt% of the feed additive of example 13 was added to the base ration formula;
test group 16: 0.3wt% of the feed additive of example 13 was added to the base ration formula;
test group 17: 0.4wt% of the feed additive of example 23 was added to the base ration formula;
test group 18: 0.5wt% of the feed additive of example 13 was added to the base ration formula;
the fasting weight of the piglets is measured at the beginning and the ending days of the test, the feed intake is recorded, and the daily gain and the feed utilization rate are calculated. And (5) observing and recording diarrhea conditions of piglets in the whole process, and calculating diarrhea rate. The test results are shown below:
as can be seen from the above table, when the total addition amount of the prebiotic, the probiotic, and the nucleotide combination is 0.3wt%, there is a significant decrease in both the feed/weight ratio and the diarrhea rate.
In summary, the best formulation of the invention is: the prebiotics comprise the following components in parts by mass: 3 parts of fructo-oligosaccharide and 1 part of galacto-oligosaccharide. The probiotics comprise the following components in parts by mass: 3 parts of lactobacillus fermentum and 3 parts of bacillus subtilis. The mass components of the nucleotide are 3 parts. The total addition amount in the feed was 0.3wt%.
Claims (2)
1. An application of a feed additive in promoting intestinal development of weaned piglets; the feed additive consists of the following components in parts by weight:
3 parts of fructo-oligosaccharide;
1 part of galacto-oligosaccharide;
3 parts of lactobacillus fermentum;
3 parts of bacillus subtilis;
1-5 parts of nucleotide;
the lactobacillus fermentumAnd bacillus subtilis are powder preparations, and the viable count of pure bacterial powder of each strain is not less than 1 x 10 10 cfu/g；
The nucleotide is obtained by taking ribonucleic acid as a raw material, hydrolyzing by an enzyme method to obtain mixed nucleotide liquid, and directly spraying and drying;
the nucleotide comprises the following components in percentage by weight: 50-70% of nucleotide, 5-15% of crude protein, 2-6% of crude fat, 12-25% of ash and 5-9% of water.
2. The use according to claim 1, wherein the feed additive is added to the weaned piglet feed in an amount of 0.05-0.5wt%.
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| CN107307203A (en) * | 2017-06-27 | 2017-11-03 | 淮北佳羊生物科技有限公司 | Weanling pig applicability formula forage |
| CN108338125A (en) * | 2018-02-07 | 2018-07-31 | 张掖市金农源生物科技有限公司 | A kind of breeding pannage and its cultural method |
| CN109770053A (en) * | 2019-01-25 | 2019-05-21 | 华中农业大学 | A kind of mixed fodder additive for early-weaned piglets |
| EP4358734A1 (en) * | 2021-06-21 | 2024-05-01 | MicroHarvest GmbH | Extracts from fast growing microbes |
| CN115553385A (en) * | 2021-07-02 | 2023-01-03 | 广州市正百生物科技有限公司 | Feed additive for improving anti-stress capability and immunity of animals, preparation method and feed |
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| CN106721247B (en) | 2020-07-14 |
| CN106721247A (en) | 2017-05-31 |
| CN111513204A (en) | 2020-08-11 |
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