CN115553385A - Feed additive for improving anti-stress capability and immunity of animals, preparation method and feed - Google Patents
Feed additive for improving anti-stress capability and immunity of animals, preparation method and feed Download PDFInfo
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- CN115553385A CN115553385A CN202110753251.7A CN202110753251A CN115553385A CN 115553385 A CN115553385 A CN 115553385A CN 202110753251 A CN202110753251 A CN 202110753251A CN 115553385 A CN115553385 A CN 115553385A
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- feed
- feed additive
- immunity
- phosphoric acid
- glycerol
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- 241001465754 Metazoa Species 0.000 title claims abstract description 39
- 239000003674 animal food additive Substances 0.000 title claims abstract description 36
- 230000036039 immunity Effects 0.000 title claims abstract description 27
- 230000002180 anti-stress Effects 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title abstract description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 82
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims abstract description 54
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims abstract description 27
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000000395 magnesium oxide Substances 0.000 claims abstract description 17
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000002773 nucleotide Substances 0.000 claims abstract description 13
- 125000003729 nucleotide group Chemical group 0.000 claims abstract description 13
- 239000000654 additive Substances 0.000 claims abstract description 12
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 9
- 239000011742 magnesium glycerophosphate Substances 0.000 claims abstract description 9
- 235000001130 magnesium glycerophosphate Nutrition 0.000 claims abstract description 9
- BHJKUVVFSKEBEX-UHFFFAOYSA-L magnesium;2,3-dihydroxypropyl phosphate Chemical compound [Mg+2].OCC(O)COP([O-])([O-])=O BHJKUVVFSKEBEX-UHFFFAOYSA-L 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 238000006243 chemical reaction Methods 0.000 claims description 24
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 238000003756 stirring Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 8
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- 235000012239 silicon dioxide Nutrition 0.000 claims description 6
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- 230000000536 complexating effect Effects 0.000 claims description 2
- 238000004321 preservation Methods 0.000 claims description 2
- 239000011777 magnesium Substances 0.000 abstract description 9
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract description 8
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract description 8
- 230000000996 additive effect Effects 0.000 abstract description 8
- 229910052749 magnesium Inorganic materials 0.000 abstract description 8
- 239000011574 phosphorus Substances 0.000 abstract description 8
- 229910052698 phosphorus Inorganic materials 0.000 abstract description 8
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- JWMUBDROCTYZKE-UHFFFAOYSA-N 2,3-dihydroxypropyl dihydrogen phosphate;magnesium Chemical compound [Mg].OCC(O)COP(O)(O)=O JWMUBDROCTYZKE-UHFFFAOYSA-N 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
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- 230000002584 immunomodulator Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
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- 102000004169 proteins and genes Human genes 0.000 description 2
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- 210000001519 tissue Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 235000019786 weight gain Nutrition 0.000 description 2
- 230000004584 weight gain Effects 0.000 description 2
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 description 1
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 description 1
- 229930192334 Auxin Natural products 0.000 description 1
- 102000016267 Leptin Human genes 0.000 description 1
- 108010092277 Leptin Proteins 0.000 description 1
- 102000011931 Nucleoproteins Human genes 0.000 description 1
- 108010061100 Nucleoproteins Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- 102000005157 Somatostatin Human genes 0.000 description 1
- 108010056088 Somatostatin Proteins 0.000 description 1
- NUFGKMPBYZTPLC-UHFFFAOYSA-H [Mg++].[Mg++].[Mg++].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OCC(O)CO Chemical compound [Mg++].[Mg++].[Mg++].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OCC(O)CO NUFGKMPBYZTPLC-UHFFFAOYSA-H 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000002363 auxin Substances 0.000 description 1
- 235000021053 average weight gain Nutrition 0.000 description 1
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- UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 description 1
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- 230000000593 degrading effect Effects 0.000 description 1
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- 150000004665 fatty acids Chemical group 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N glycerol 1-phosphate Chemical compound OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
- 230000034659 glycolysis Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 244000144993 groups of animals Species 0.000 description 1
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- SEOVTRFCIGRIMH-UHFFFAOYSA-N indole-3-acetic acid Chemical compound C1=CC=C2C(CC(=O)O)=CNC2=C1 SEOVTRFCIGRIMH-UHFFFAOYSA-N 0.000 description 1
- 229910001410 inorganic ion Inorganic materials 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 210000002977 intracellular fluid Anatomy 0.000 description 1
- 229940039781 leptin Drugs 0.000 description 1
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
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- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
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- 230000011164 ossification Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical compound C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 description 1
- 229950004354 phosphorylcholine Drugs 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 230000001007 puffing effect Effects 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
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- 230000028327 secretion Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
- 229960000553 somatostatin Drugs 0.000 description 1
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- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/26—Compounds containing phosphorus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/153—Nucleic acids; Hydrolysis products or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- Inorganic Chemistry (AREA)
- Birds (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
Abstract
The invention relates to a feed additive for improving the anti-stress capability and immunity of animals, a preparation method and a feed, wherein the feed additive is prepared from the following raw materials in percentage by weight: 20-35% of glycerol, 30-45% of phosphoric acid, 7-12% of magnesium oxide, 15-20% of nucleotide and 10-20% of an anti-caking agent; at least a portion of the glycerol, at least a portion of the phosphoric acid, and at least a portion of the magnesium oxide react to form magnesium glycerophosphate. The additive can supplement organic phosphorus and organic magnesium for animal body, promote animal bone growth, increase ingestion, resist oxidative stress, and improve animal immunity.
Description
Technical Field
The invention relates to the technical field of feed additives, in particular to a feed additive for improving the anti-stress capability and immunity of animals, a preparation method and a feed.
Background
Intensive culture conditions and countries have increasingly strict requirements on environmental protection, and in order to improve culture benefits, a high-density culture mode is often adopted in a farm, namely, the culture quantity of a unit area is improved by a method. Meanwhile, because the population base of China is large, and the feed resources for breeding animals are relatively deficient, the low-protein daily ration scheme for the animals is recommended in 2020 in China, and the addition of growth-promoting antibiotic additives in the feed is prohibited from being added in China from 7 months and 1 days in 2020, farmers find that the health degree of the animals is poor, the immunity is reduced, the growth performance is reduced, and the breeding benefit is reduced. Under the condition, development of animal skeletons is promoted by efficiently supplementing organic phosphorus and organic magnesium, so that the feed intake is increased, various oxidative stresses are resisted, the immunity is improved, and the improvement of the culture economic benefit is very necessary.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide the feed additive for improving the anti-stress capability and the immunity of animals, the preparation method and the feed.
In order to realize the aim of the invention, the invention provides a feed additive for improving the anti-stress capability and the immunity of animals, which is prepared from the following raw materials in percentage by weight: 20-35% of glycerol, 30-45% of phosphoric acid, 7-12% of magnesium oxide, 15-20% of nucleotide and 10-20% of an anti-caking agent; at least a portion of the glycerol, at least a portion of the phosphoric acid, and at least a portion of the magnesium oxide react to form magnesium glycerophosphate.
Preferably, the glycerol and the phosphoric acid account for 50 to 65 percent of the raw materials by weight percentage.
Preferably, the molar ratio of glycerol to phosphoric acid is 1:1.
preferably, the anti-caking agent is silica.
In order to achieve the purpose of the invention, the invention also provides a method for preparing the feed additive for improving the anti-stress capability and the immunity of animals, which comprises the following steps: the method comprises the following steps: reacting glycerol with phosphoric acid, and then adding magnesium oxide for complexing to obtain a product containing magnesium glycerophosphate; step two: and (4) mixing the product obtained in the step one with nucleotide and an anticaking agent to obtain the feed additive.
Preferably, in the first step, glycerol is added into the reaction vessel, stirring and heating are carried out, then phosphoric acid is slowly added, the reaction is continuously carried out under the condition of heat preservation and stirring, then magnesium oxide is added, the reaction is continuously carried out under the condition of stirring, and the reaction is stopped after the pH value of the reaction solution is measured to be 6.2-7.0.
Preferably, the glycerol is added to the reaction vessel and stirred and heated to 90 ℃; slowly adding phosphoric acid, and then continuing to keep the temperature and stir for reaction for 2 hours.
Preferably, the phosphoric acid is added within one hour.
In order to achieve the aim of the invention, the invention also provides a feed which comprises the feed additive for improving the anti-stress capability and the immunity of the animals or the feed additive for improving the anti-stress capability and the immunity of the animals prepared by the method.
Preferably, the feed is weaned piglet basic ration or growing-finishing pig basic ration, and the addition amount of the feed additive is 500g/T. The adding method is that the feed additive is mixed with part of feed and/or other additives to form a premix, and then the premix is uniformly mixed with the rest feed.
Compared with the prior art, the invention can obtain the following beneficial effects:
the reaction and complexation of glycerol, phosphoric acid and magnesium oxide form a glycerol magnesium phosphate complex, and the mixing compatibility of nucleotide is added, so that the cost is lower and the effect is similar to that of the existing immunomodulator, anti-stress additive and feed intake improving additive. In addition, compared with the common additive, the additive is more suitable for the processing technology requirement of high-temperature expanded feed, and has the advantages of stable functional factors, low price and better economic benefit. Specifically, the feed additive can be used for supplementing organic phosphorus and organic magnesium, promoting the development of animal bones and improving the body shape; regulating the endocrine system of animals, reducing the expression level of growth hormone factors, thereby promoting the muscle growth of animals; resisting oxidative stress, helping organism recover fatigue, and improving immunity; obviously improving the production performance, improving the endogenous feed intake, reducing the excrement, reducing the feed conversion ratio and increasing the daily gain; so that the animal fur is bright and has strong activity; improve slaughtering index, improve carcass quality, make meat color bright red, and obviously enhance water power of muscle system.
Detailed Description
The invention forms the phosphoglycerol magnesium complex by the reaction and complexation of glycerol, phosphoric acid and magnesium oxide, and prepares the feed additive for improving the anti-stress capability and the immunity of animals by mixing and compounding the phosphoglycerol magnesium complex and nucleotide.
Wherein, glycerin, also called glycerol, is a skeleton component of triglyceride molecules, has strong functions of moisture retention and moisture retention, and can effectively lock water and resist oxidation in animal bodies; complete oxidation of glycerol per gram can produce 4 kcal of calories, and is a very effective energy supplement for animals against stress.
Phosphorus is involved in bone formation in the body, in the form of phospholipids in the composition of cell membranes, and at the same time, phosphorus is one of the components of high-energy phosphate bonds, and its role in energy metabolism is of great importance. Phosphorus is associated with the activity of enzymes in many metabolic processes by altering 2,3-glycerodiphosphate concentration (requiring Mg) 2+ Participate in) to regulate the transport of oxygen to tissues, and play an important role in maintaining the environmental balance in the body.
Magnesium is an important inorganic ion in animal cells, coexists with potassium ion in intracellular fluid, and can activate various enzymes in vivo, inhibit nerve excitation, maintain stable nucleic acid structure, and participate in protein synthesis, muscle contraction and thermoregulation. Magnesium also has antioxidant effects, and can inhibit lipid oxidation and the production of peroxide in muscle, thereby protecting the integrity of cell tissue, participate in various physiological activities such as enzymatic reaction, and maintain the growth of animal bone, regulate neuromuscular activity, and maintain the function of hormone secreted from gastrointestinal tract. Magnesium is also strongly associated with digestive system diseases, and peptic ulcers of gastrointestinal tract.
Phosphoglycerides, also known as phospholipids, made from glycerol and phosphoric acid are the basic materials that make up biological membranes. Phospholipids differ from fats in that the 1 hydroxyl group of glycerol is not bound to a fatty acid as an ester, but rather to phosphoric acid and its derivatives, such as phosphorylcholine, to form the most important class of phospholipids in cells. The phosphoglycerol is one of common molecules in biological cells, is also an intermediate product in glycolysis and Calvin cycle processes, and can provide energy for organisms, resist various stresses and improve the immunity of the organisms.
The magnesium glycerophosphate obtained after the reaction of the phosphoglyceride and the magnesium oxide can be used for supplementing organic phosphorus and organic magnesium, promoting the growth of bones, resisting oxidative stress and improving the immunity. The chemical formula of magnesium glycerophosphate is shown below:
the nucleotide can be obtained by degrading nucleic acid, and can be used as a second messenger of multiple hormones in an animal body, so that the concentration of LP (leptin) in the animal body can be remarkably increased, the secretion of Growth Hormone (GH) is promoted, the activity of acetyl coenzyme A carboxylase is reduced, fat synthesis is inhibited, amino acid is promoted to enter cells, protein kinase is activated, certain proteins of a nucleoprotein body in cytoplasm are phosphorylated, and the synthesis of the proteins is promoted, so that the growth of the animal is promoted, and the immunity of the animal body is favorably improved.
The feed additive for improving the anti-stress capability and the immunity of animals is prepared by reaction complexation and matching of the substances, and can supplement organic phosphorus and organic magnesium for the animals, promote the development of animal bones and improve the body shapes; can regulate animal endocrine system, reduce somatostatin factor (SS) expression level, and promote animal muscle growth; resisting oxidative stress, relieving fatigue, and improving immunity.
The product dosage and the using method of the invention are as follows: 500g of the feed is added into each ton of feed, and the feed is diluted into a premix by 10 times or mixed with other additives into the premix and then added with large materials for uniform mixing. The premix and the concentrated material are added in proportion, and the high-temperature resistant processing can be realized. Moreover, the feed additive is more suitable for the processing technological requirements of high-temperature expanded feed, and has the advantages of stable functional factors, low price and better economic benefits.
The present invention will be described in further detail with reference to specific embodiments.
Example 1
The raw material components are as follows: glycerol, phosphoric acid, magnesium oxide, nucleotide and anticaking agent silicon dioxide.
The raw material ratio is as follows: 29% of glycerol, 31% of phosphoric acid, 10% of magnesium oxide, 15% of nucleotide and 15% of silicon dioxide.
The preparation method comprises the following steps: adding glycerol into a reaction kettle, opening and stirring, heating to 90 ℃ in the reaction kettle, slowly adding phosphoric acid, finishing adding within one hour, continuously preserving heat, stirring and reacting for 2 hours, then adding magnesium oxide, continuously stirring and reacting, stopping reaction after measuring the pH value of a reaction solution to be 6.2-7.0 to obtain a magnesium glycerophosphate product, fully and uniformly mixing the magnesium glycerophosphate reactant, nucleotide and anticaking agent silicon dioxide, cooling by a vibrating screen, and sieving to obtain a finished product.
Test 1:
the feed additive product obtained in the above example 1 was added to daily ration for weaned piglets for evaluation of the effect of application.
Test time: year 2020, 6, 7.
Test site: shandong Linyi Junuo county Ponuo farm.
The 240 28-day-old weaned piglets are divided into 3 groups according to male parents, varieties and body weights. Three groups were fed with different diets for 36 days of the test.
Control group: feeding basic ration.
Test group a: adding phytosterol and cysteamine auxin (total addition amount is 500 g/T) into basal diet for feeding.
Experiment group B: the feed additive obtained in example 1 was added at a ratio of 500g/T to a basal diet. The test results are shown in table 1 below.
TABLE 1 weaned piglet test results
| Item | Control group | Test A group | Test group B |
| Number of heads (head) | 80 | 80 | 80 |
| Test time (sky) | 36 | 36 | 36 |
| Initial weight (jin) | 16.77 | 16.31 | 15.80 |
| Initial weight (jin) | 20.96 | 20.39 | 19.76 |
| Feed intake (jin) | 49.42 | 51.37 | 57.22 |
| Equal ingestion head (jin) | 61.78 | 64.22 | 71.54 |
| First average daily feed intake (jin/day/head) | 1.72 | 1.78 | 1.99 |
| Ending weight (jin) | 47.02 | 49.61 | 55.34 |
| End weight balancing (jin) | 58.77 | 62.02 | 69.16 |
| Weight gain (jin) | 30.24 | 33.30 | 39.53 |
| Average weight gain (jin/tou) | 37.81 | 41.62 | 49.42 |
| Daily gain (jin/day) | 1.05 | 1.16 | 1.37 |
| Material to weight ratio | 1.63 | 1.53 | 1.45 |
| Number of diarrhea heads (head) | 16 | 10 | 12 |
| Diarrhea Rate (%) | 0.56 | 0.34 | 0.42 |
| Survival rate (%) | 100 | 100 | 100 |
Test 2:
the feed additive product obtained in the example 1 is added into daily ration of growing-finishing pigs for evaluation of application effect.
Test time: 9/20/2020.
Test site: shandong Linyi Junuo county Ponuo farm.
The 260 fattening pigs are divided into 2 groups according to male parents, breeds and body weights. Two groups were fed with different diets for a test period of 40 days.
Control group: feeding basic ration.
Test groups: the feed additive obtained in example 1 was added at a ratio of 500g/T to a basal diet.
The test results are shown in table 2 below.
TABLE 2 growing-finishing pig test results
| Item | Control group | Test group | Degree of improvement |
| Number of heads (head) | 130 | 130 | —— |
| Test time (sky) | 40 | 40 | —— |
| Initial weight (kilogram/head) | 86.02 | 86.90 | —— |
| Test weight (kg/head) | 128.01 | 136.34 | +6.52％ |
| Average head weight gain (kilogram) | 42.04 | 49.44 | +17.71％ |
| Daily gain of head (kilogram) | 1.05 | 1.24 | +17.71％ |
| Total feed intake (kilogram) | 142.40 | 154.00 | +8.11％ |
| Daily average food intake (kilogram) | 3.56 | 3.85 | +8.11％ |
| Material to weight ratio | 3.39 | 3.11 | -8.16％ |
As can be seen from the above experiments 1 and 2, the novel feed nutrition additive of the embodiment 1 can produce a good effect of obviously promoting ingestion when being used in various age groups of animals, can adjust immunity and anti-stress reaction, improves fur and body shapes, improves production performance, and has remarkable economic benefit. In addition, the product has stable property, and the biological activity of the product is not influenced by high-temperature granulation and puffing and the like. Compared with an immunomodulator, an anti-stress additive and an additive for improving the feed intake, the feed additive provided by the invention is lower in cost and close in effect.
Example 2
The present example is basically the same as example 1, except that the raw material ratio of the present example is: 28% of glycerol, 30% of phosphoric acid, 12% of magnesium oxide, 15% of nucleotide and 15% of silicon dioxide.
Example 3
The present example is basically the same as example 1, except that the raw material ratio of the present example is: 35% of glycerin, 33% of phosphoric acid and 7% of magnesium oxide; nucleotide 15% and silicon dioxide 10%.
Tests prove that similar to the example 1, the feed additives of the examples 2 and 3 can also obviously improve the production performance: the endogenous feed intake is improved by 10 to 15 percent, the feces are reduced by 15 to 30 percent, the feed-meat ratio is reduced by 5 to 10 percent, and the daily gain is improved by 15 to 20 percent. In addition, the feed additive can ensure that animal fur is bright and strong in activity, and the slaughter index is improved: the carcass quality is improved, the meat color is bright red, and the hydraulic power of muscle is obviously enhanced.
Finally, it should be emphasized that the above-described embodiments are merely preferred embodiments of the present invention, and are not intended to limit the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The feed additive for improving the anti-stress capability and the immunity of animals is characterized by being prepared from the following raw materials in percentage by weight: 20-35% of glycerol, 30-45% of phosphoric acid, 7-12% of magnesium oxide, 15-20% of nucleotide and 10-20% of an anti-caking agent;
at least a portion of the glycerol, at least a portion of the phosphoric acid, and at least a portion of the magnesium oxide react to form magnesium glycerophosphate.
2. The feed additive for improving the anti-stress capability and the immunity of animals according to claim 1, characterized in that the glycerol and the phosphoric acid account for 50 to 65 percent of the weight of the raw materials.
3. The feed additive for improving the anti-stress ability and immunity of animals according to claim 1 or 2, wherein the anti-caking agent is silicon dioxide.
4. The feed additive for improving the anti-stress capability and immunity of animals according to claim 1 or 2, characterized in that the molar ratio of the glycerol to the phosphoric acid is 1:1.
5. a method for preparing the feed additive for improving the anti-stress capability and immunity of animals according to any one of claims 1 to 4, which is characterized by comprising the following steps:
the method comprises the following steps: reacting the glycerol with the phosphoric acid, and then adding the magnesium oxide for complexing to obtain a product containing magnesium glycerophosphate;
step two: and (3) mixing the product obtained in the step one with the nucleotide and the anticaking agent to obtain the feed additive.
6. The method according to claim 5, wherein in the first step, the glycerol is added into the reaction vessel, stirred and heated, then the phosphoric acid is slowly added, the reaction is continued under stirring at a constant temperature, then the magnesium oxide is added, the reaction is continued under stirring, and the reaction is stopped after the pH of the reaction solution is measured to be 6.2-7.0.
7. The method according to claim 6, characterized in that the glycerol is added to the reaction vessel, stirred and heated to 90 ℃; after the phosphoric acid is slowly added, the reaction is continued for 2 hours under the condition of heat preservation and stirring.
8. The method of claim 6, wherein the phosphoric acid is added within one hour.
9. A feed comprising the feed additive for improving the anti-stress ability and immunity of an animal according to any one of claims 1 to 4 or the feed additive for improving the anti-stress ability and immunity of an animal prepared by the method according to any one of claims 5 to 8.
10. The feed according to claim 9, wherein the feed is a basal diet for weaned piglets or a basal diet for growing-finishing pigs, the feed additive is added in an amount of 500g/T, and the feed additive is added by mixing the feed additive with a part of the feed and/or other additives to form a premix and then uniformly mixing the premix with the rest of the feed.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117137046A (en) * | 2023-07-28 | 2023-12-01 | 广州市正百饲料科技有限公司 | Functional feed additive for improving fertility of sow as well as preparation method and application thereof |
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