CN101530159A - Feed additive for feeding animals and application thereof - Google Patents
Feed additive for feeding animals and application thereof Download PDFInfo
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- CN101530159A CN101530159A CN200810010614A CN200810010614A CN101530159A CN 101530159 A CN101530159 A CN 101530159A CN 200810010614 A CN200810010614 A CN 200810010614A CN 200810010614 A CN200810010614 A CN 200810010614A CN 101530159 A CN101530159 A CN 101530159A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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Abstract
A feed additive for feeding animals adopts pyrrole quinoline quinone (PQQ) as an active and effective ingredient. The feed additive PQQ can improve the reproductive performance of feeding animals obviously and can be widely applied in feeding livestock, poultry and aquatic animals without any harm to animals, human and environment.
Description
Technical field
The present invention relates to the cultivated animals feed, be a kind of new additive for animal feed PQQ (pyrroloquinoline quinone specifically, be called for short PQQ), it can promote growing of livestock and poultry, aquatic product animal, improve the laying rate of laying hen and the weight of laying eggs, and strengthen the immune resistivity of cultivated animals such as livestock and poultry, aquatic products, also relate to the using method of this feed addictive on the variety classes cultivated animals simultaneously.
Background technology
PQQ found from microorganism early than 1979, is a kind of organic molecule that extensively is formed in the bodies of aminal and plant.PQQ is the prothetic group of the prothetic group of multiple important enzyme in the bacterium, particularly some oxidoreducing enzyme.Studies show that, use the forage feed mouse that lacks PQQ, the mouse poor growth, fertility is poor, the skin fragility; And in these mouse, the mitochondrial quantity and the function that are called as energy factory obviously descend.Simultaneously, PQQ has very strong radical scavenging activity, the multiple disease that the opposing free radical causes, and its removing ability is 50-100 times of ascorbic acid.
The mechanism of action of PQQ and the two class factors (vitamin and polypeptide type cytokines) have the mechanism of action of acquaintance.First, PQQ participates in biological metabolic oxidation-reduction process as the prothetic group of quinoprotein enzyme, transmits idea, and growth institute energy requirement is provided, participate in body fat, carbohydrate, protein and nucleic acid metabolism simultaneously, play the physiological function identical with the B family vitamin.In addition, PQQ is as some other oxidoreducing enzyme, as the prothetic group of cuprammonium oxidizing ferment, nitrilase, and harmful substance such as cracked ammonium, nitrile and play detoxication in vivo.The second, PQQ plays with vitamin E and similarly acts on, and stimulates synthesizing coenzyme Q, strengthens the antitoxin and detoxication of body to hydrogen peroxide, aflatoxin, nitrous compound, and immunity of organisms is provided.PQQ and NADPH reaction generate PQQH2, participate in interior free yl and remove.PQQ participates in the protection of biological self reproducing function and keeps effect, regulates hormone by hypothalamus-anterior pituitary, promotes gonad development, improves fecundity.The 3rd, PQQ is similar to some peptide growth factors such as skin factor, IGF, can combine with some acceptor molecules on the cell membrane, its conformation is changed, thereby cause this acceptor to be activated at the specially property protease of cell membrane inboard, make the interior multiple target protein of its catalysis cell carry out phosphorylation reaction, the target protein by these phosphorylations starts a series of biochemical reactions relevant with division in the cell then, thus the propagation of realization cell.
In prokaryotes, plant and mammal, all extensively exist PQQ, it is not only the prothetic group of many enzymes, is undertaking the function of transmitting electronics, proton and chemical group in enzymatic reaction, can also stimulating plant the growing and reproductive performance of growth and animal.
List of references:
1.Salisbury-SA，Forrest-HS，Cruse-WB，Kennard-O.A?novel?coenzyme?frombacterial?primary?alcohol?dehydrogenases[J].Nature?280：843-844，
2.Tramontano?J.Am.Chem.Soc.1981，103：5599-5600
3.Janes-SM；Mu-D；Wemmer-D；Smith-AJ；Kaur-S；Maltby-D；Burlingame-AL；Klinman-JP.A?new?redox?cofactor?in?eukaryotic?enzymes；6-hydroxydopa?at?theactive?site?of?bovine?serum?amine?oxidase[J].Science?1990，248：981-987
Summary of the invention
The object of the invention is intended to the feed addictive as a kind of new type of safe with PQQ, adds in the middle of the feed of cultivated animals such as livestock and poultry, aquatic products, plays to promote growth of animal, the effect that improves aspects such as its reproductive performance.
A kind of cultivated animals feed addictive, it is an active and effective with pyrroles's quinoline purine quinone, pyrroles's quinoline purine quinone English is pyrroloquinoline quinone, abbreviation PQQ.
Described pyrroles's quinoline purine quinone PQQ is meant that the employing microbe fermentation method prepares the PQQ product of producing, the PQQ product that passes through to adopt the PQQ product of chemical synthesis process production or extraction preparation from natural plants.
Described feed addictive also contains carrier, and PQQ and carrier are re-dubbed final products; Described carrier can be mineral salts and/or carbon aqueous polymer, and wherein the weight content of carrier can be 30%-99%; Described mineral salts is silica, calcium carbonate or zeolite etc.; The carbon aqueous polymer is starch, dextrin, powdered glucose or corncob etc.
Described feed addictive can add in the cultivated animals feed, and described cultivated animals can be livestock and poultry, aquatic product animal and/or ruminates cultivated animals etc.It can promote that cultivated animals grows, the immunocompetence that improves survival rate and feed conversion rate and improve animal body.
The appropriate addn amount of PQQ feed addictive of the present invention in the cultivated animals feed is 0.1ppm-10ppm, in this interpolation scope, this feedstuff additive product can obviously improve the speed of growth of cultivated animals, reduces the death rate of animal, improves immunocompetence and the reproductive performance of animal.
PQQ is as a kind of feed addictive of new type of safe, promoting livestock and poultry, aquiculture animal growth, improving aspect such as its reproductive performance and have important effect.In the feed that adds feed addictive PQQ was fed the cultivated animals process, the immune resistivity and the survival rate of all kinds of cultivated animals all increased.
The feed addictive PQQ of invention can significantly improve the production performance of cultivated animals, can be widely used in livestock and poultry, the aquaculture of aquatic animal animal, the mankind and environment not being had any harm.
Illustrate that below by concrete not homozoic culture experiment PQQ feed addictive of the present invention improves the speed of growth of cultivated animals, reduce the death rate of animal, strengthen the immunocompetence of animal and the effect of reproductive performance.
The specific embodiment
PQQ can be commercial or can be prepared with reference to following document:
1.Ameyama?M，Hayash?iM，M?atsush?ita?K，et?al.M?icrobial?p?roduction?ofpyrro?loquino?line?quinone[J].A?gric?Bio?l?Chem，1984，48(2)：5612565.
2.van?Kleef?M?AG，Duine?J?A.Facto?rs?relevant?inbacterial?pyrro?loquinoline?quinone?p?roduction[J].App?lied?and?Envi2?ronmentalM?icrobio?logy，1989，55(5)：1?20921?213.
3.Co?rey?E?J，A?lfonso?T.To?tal?synthesis?of?the?quinono?id?alco2?ho?ldehydrogenase?coenzyme(1)of?methylo?troph?ic?bacteria[J].J?Am?Chem?Soc，1981，103(18)：5?59925?600.
4. Yin Fang etc. deliver＜methyl alcohol utilizes the condition of culture of type bacterial fermentation production pyrroles quinoline purine quinone 〉, the journal Vol.30 No.22004-04 of East China University of Science, 227-233.
Embodiment 1: the present invention adopts microorganism (bacterium) fermentation process, acquisition can be used for adding to biologically active PQQ product in the variety classes cultivated animals feed.
Embodiment 2: the effect of feed addictive PQQ on feeding dorking
PQQ added in the common meat chick fodder (being the experimental basis daily ration) to raising table hens according to 4ppm, 42 ages in days are delivered for sale, and the growth rate of chicken is accelerated, and the equal weight ratio control group of experimental group chicken is high more than 4%.
The PQQ feed addictive is to the effect test of meat chick production performance
1. experimental design
This test has designed 4 groups altogether, i.e. control group, the test group of three various dose PQQ that fed.The basal diet and the base additive (multivitamin, trace element, amino acid etc.) of each group are identical.Detailed design sees Table 1.
The PQQ additive capacity (ppm) of each experimental group of table 1
2. experimental animal
Select healthy 1 age in days Ai Wei mattress commodity for mixing 800 of chick, be divided into 4 groups at random, 200 every group, and every component is 5 repetitions.1 Japanese instar chickling body weight difference is not remarkable after measured, and average weight is 46.5 grams/only.
3. test daily ration
The experimental basis daily ration is divided into each stage basal diet composition of two stages (1-21,22-42) and nutritional labeling sees Table 2
Each stage basal diet of table 2 is formed (weight %) and nutritional labeling (Mcal/Kg, thermie/kilogram)
| Daily ration is formed | The 1-21 age in days | The 22-42 age in days |
| The big dregs of beans of corn (Huang), 2 grade corn protein powders, 2 calcium monohydrogen phosphate stone flours | 57.12 32.00 4.00? 1.98? 1.30? | 61.06 27.50 4.00? 1.80? 1.20? |
| Salt animal oil methionine lysine 1% premix fowl metabolizable energy, (Mcal/kg) crude protein, (%) crude fat, (%) calcium, (%) total phosphorus, (%) available phosphorus, (%) lysine, (%) methionine, (%) egg+cystine, (%) threonine, (%) tryptophan, (%) arginine, (%) | 1.81 0.26 0.23 1.00 0.30 (chicken) 2.93 21.30 5.00 1.00 0.65 0.45 1.12 0.55 0.90 0.85 0.28 1.35 | 0.30 2.73 0.21 0.21 1.00 (middle chickens) 3.03 19.63 6.00 0.93 0.60 0.41 1.00 0.47 0.80 0.78 0.25 1.22 |
4. feeding and management
Each test group adopts online putting down to support free choice feeding and drinking-water under same raising and management condition.Illumination in 23 hours, the feeding standard control routinely of house temperature, immune programme for children carries out immunity inoculation routinely.
5. experimental observation index
(1) body weight determination: measure respectively and respectively organize 21,42 age in days whose body weights.
(2) feed consumption rate is measured: the feeding coal of weighing and record each group every day, and weigh and settle accounts feed consumption rate before this simultaneously.
(3) extremely wash in a pan quantitative determination: every day, detail record was respectively organized death and the superseded quantity of chicken.
6, test results and analysis
Meat chick production performance is respectively organized in table 3 test
By the data in the last table 3 as can be known, add rate of body weight gain and the survival rate that PQQ can improve the meat chick in the meat chick fodder, feed coefficient also decreases simultaneously.Feed addictive PQQ can significantly improve the production performance of meat chick.
Embodiment 3: the effect of feed addictive PQQ on the pig of feeding
Add PQQ in the common pig feed (being the experimental basis daily ration) raising pig according to 6ppm, delivered for sale in 115 days, the equal weight ratio control group of experimental group pig is high more than 8%.
The PQQ feed addictive is to the effect test of growing-finishing pig production performance
1, experimental design
This test has designed 4 groups altogether, i.e. control group, the test group of three various dose PQQ that fed.The basal diet and the base additive (multivitamin, trace element, amino acid etc.) of each group are identical.Detailed design sees Table 4.Omnidistance 115 days of this test.
The PQQ additive capacity (ppm) of each experimental group of table 4
2. experimental animal
Select healthy PIC commodity for 48 of piglets, after conventional program vaccinate, expelling parasite, beating overbit and breeding observing,, be divided into 4 groups at random according to the approaching principle of each group average weight, 12 every group, male and female half and half, and every component is 3 repetitions.It is not remarkable respectively to organize average weight difference after measured.
3. test daily ration
The experimental basis daily ration is formed and nutritional labeling sees Table 5
Table 5 experimental basis daily ration is formed (weight %) and nutritional labeling (Mcal/Kg, thermie/kilogram)
| Daily ration is formed | Piglet | The growth pig | Growing and fattening pigs |
| Corn, the 2 grades of big dregs of beans cottonseed of wheat bran dregs of rice rapeseed dregs methionine calcium monohydrogen phosphate stone flour animal oil salt | 68.50 ----? 18.80 6.00? 3.00? ----? 1.20? 1.00? 0.50? ---- | 70.20 7.00? 13.00 4.00? 2.00? 0.10? 0.95? 0.95? 0.50? 0.30? | 71.30 13.00 7.00? 3.00? 2.00? ----? 0.30? 1.10? 1.00? 0.30? |
| 1% premix pig digestible energy (Mcal/kg) crude protein (%) crude fat (%) calcium (%) total phosphorus (%) available phosphorus (%) lysine (%) methionine (%) egg+cystine (%) threonine (%) tryptophan (%) arginine (%) | 1.00? 3.18? 17.53 3.40? 0.70? 0.59? 0.36? 0.94? 0.28? 0.61? 0.67? 0.21? 1.13? | 1.00? 3.18? 15.06 3.60? 0.61? 0.54? 0.31? 0.72? 0.25? 0.64? 0.56? 0.18? 0.93? | 1.00? 3.21? 13.01 4.23? 0.52? 0.44? 0.20? 0.53? 0.22? 0.49? 0.47? 0.15? 0.77? |
4, feeding and management
The test pig house is open colony house, adopts ground flat to support, the dry powder feeding of feeding, free choice feeding and nipple drinking device drinking-water.Feeding standard control and routine immunization program are carried out immunity inoculation routinely.
5, test observation project and method
(1) body weight determination: determination test starting weight, 60 days (the about 60Kg of body weight), test end weigh respectively, carry out whose body weight before early raising on an empty stomach.
(2) feed consumption rate is measured: the feeding coal of weighing and record each group every day, and weigh and settle accounts feed consumption rate before this simultaneously.
(3) extremely wash in a pan quantitative determination: detail record is respectively organized pig death and superseded quantity only.
6. test results and analysis
Table 6 variable concentrations PQQ is to the influence of pig production performance
| 1 | 2 | 3 | 4 | |
| Average starting weight (Kg) | 24.8±1.6 | 24.2±1.2 | 24.3±1.5 | 24.6±1.1 |
| Average end heavy (Kg) | 100.1±7.8 | 103.4±6.6 | 106.7±7.2 | 109.3±6.8 |
| Average total augment weight (Kg) | 75.3 | 79.2 | 82.4 | 84.7 |
| Average omnidistance daily gain (g) | 654.8 | 688.7 | 716.5 | 736.5 |
| Omnidistance material anharmonic ratio | 3.36 | 3.28 | 3.22 | 3.16 |
| Survival rate % | 100.0 | 100.0 | 100.0 | 100.0 |
By the data in the table 6 as can be known, adding PQQ and can improve the body weight gains of pig in pig feed, is useful for the production performance that improves pig.
Embodiment 4: the effect of feed addictive PQQ on the fish of feeding
PQQ added to according to 6ppm omnidistancely in the common carp feed (being the experimental basis daily ration) raises carp, go out the pool after, the equal weight ratio control group of experimental group fish is high more than 12%.
The PQQ feed addictive produces the effect test of performance to sashimi (raw fish)
1, experimental design
This test has designed 4 groups altogether, i.e. control group, the test group of three various dose PQQ that fed.The basal diet and the base additive (multivitamin, trace element, amino acid etc.) of each group are identical.Detailed design sees Table 7.Omnidistance 56 days of this test.
The PQQ additive capacity (ppm) of each experimental group of table 7
2, test fish and experiment material
Select healthy carp, the about 80g of the equal quality of tail, totally 400 tails are all put in a suitable place to breed.Test is carried out in net cage, and cage size is 2.0m x 2.0m x 1.0m.Experiment is divided into 4 groups, and each organizes 2 parallel tests, totally 8 net cages.The water source is underground well water.
3, test daily ration
The experimental basis daily ration is formed and nutritional labeling sees Table 8
Table 8 experimental basis daily ration is formed and nutritional labeling
| Raw material | Proportioning (kg/ criticizes) |
| Fish meal, Peru | 9.03 |
| Big dregs of beans | 12.00 |
| Expanded soybean | 20.00 |
| Rapeseed dregs 37 | 20.86 |
| The cottonseed dregs of rice, 2 grades | 16.77 |
| 2 grades of wheats | 16.50 |
| Calcium dihydrogen phosphate | 1.80 |
| Vegetable oil | 1.64 |
| Salt salt | 0.20 |
| Choline Chloride | 0.20 |
| Premix (1%) | 1.00 |
| Digestible energy (Mcal/kg) | 3.15 |
| Crude protein (%) | 34.00 |
| Digestible protein (%) | 0.00 |
| Crude fat (%) | 4.00 |
| Crude fibre (%) | 10.00 |
| Coarse ash (%) | 12.00 |
| Calcium (%) | 0.30 |
| Total phosphorus (%) | 0.90 |
| Available phosphorus (%) | 0.58 |
| Lysine (%) | 1.80 |
| Methionine (%) | 0.60 |
| Cystine (%) | 0.00 |
| Egg+cystine (%) | 1.00 |
4, feeding experiment, record and test item
The food situation of robbing according to fish is determined every group of inventory every day.Accurately take by weighing feed, divide and throw something and feed for 3 times: morning 6:00-7:00, noon 13:00-14:00, evening 19:00-20:00.Measure water temperature and dissolved oxygen content every day, do 1 water quality detection weekly.The heavy body weight of respectively organizing carp of off-test time-division another name, number of computations is calculated indexs such as weightening finish situation, feedstuff-meat ratio, the death rates simultaneously, and result of the test is carried out overall merit.
Table 9 variable concentrations PQQ is to the influence of carp rate of body weight gain, feed coefficient and survival rate
By the data in the last table as can be known, in carp feed, add PQQ and can improve rate of body weight gain and the survival rate of carp more significantly, also reduced feed coefficient simultaneously.Feed addictive PQQ is very useful for the production performance that improves carp.
Embodiment 5: the effect of feed addictive PQQ on the prawn of feeding
Add PQQ in the common Penaeus Vannmei feed (being the experimental basis daily ration) raising Penaeus Vannmei according to 6ppm, after prawn went out the pool, the equal weight ratio control group of experimental group prawn was high more than 15%.
The effect test of PQQ feed addictive prawn production performance
1, experimental design
This test has designed 3 groups altogether, i.e. control group, the test group of two various dose PQQ that fed.The basal diet and the base additive (multivitamin, trace element, amino acid etc.) of each group are identical.Detailed design sees Table 10.Omnidistance 56 days of this test.
The PQQ additive capacity (ppm) of each experimental group of table 10
2, test shrimp and experiment material
Select healthy Penaeus Vannmei, the about 1.0g of the equal weight of tail, be divided into 4 groups at random, 1 group is control group, the basal feed of feeding, and the 2-4 group is test group, feed and add the test feed of different metering PQQ, establish 3 aquariums for every group, each aquarium 300L flowing water capable of circulation filters, and puts 50 tail shrimps in each aquarium in a suitable place to breed.The test water source is the natural sea-water after husky filter, the sterilization.
3, test daily ration
The experimental basis daily ration is formed and nutritional labeling sees Table 11
Table 11 experimental basis daily ration is formed and nutritional labeling
| Raw material | Proportioning (kg/ criticizes) |
| Fish meal, Peru | 34.00 |
| Peanut meal | 24.70 |
| Rice bran (containing fat) | 2.38 |
| Rapeseed dregs | 3.00 |
| The cottonseed dregs of rice, 2 grades | 16.77 |
| Wheat bran, 1 grade | 5.26 |
| Calcium dihydrogen phosphate | 1.50 |
| Flour | 22.00 |
| Fish oil | 1.80 |
| Choline Chloride | 0.20 |
| Prawn vitamin | 0.20 |
| Adhesive | 0.20 |
| Betaine | 0.10 |
| Composite trace element | 0.66 |
| Digestible energy (Mcal/kg) | 3.22 |
| Crude protein (%) | 40.00 |
| Digestible protein (%) | 34.34 |
| Crude fat (%) | 5.20 |
| Crude fibre (%) | 3.60 |
| Coarse ash (%) | 9.14 |
| Calcium (%) | 1.70 |
| Total phosphorus (%) | 1.61 |
| Available phosphorus (%) | 0.92 |
| Lysine (%) | 2.31 |
| Methionine (%) | 0.83 |
| Cystine (%) | 0.42 |
| Egg+cystine (%) | 1.21 |
4, feeding experiment, record and test item
Accurately take by weighing feed, divide and throw something and feed for 3 times: morning 7:00-8:00, noon 15:00-16:00, evening 21:00-22:00.Preceding 2 weeks throw something and feed by 8% of body weight, do not have residual bait.Claim a body weight in 3,6,8 weeks, adjust feeding volume according to body weight, duration of test circulation flowing water continues oxygenation with aerator, 23-30 ℃ of test water temperature.During off-test, add up the survival rate of every case shrimp, the TBW of the every case shrimp of weighing behind the 24h that stops to throw something and feed calculates rate of body weight gain.And result of the test carried out overall merit.
Table 12 variable concentrations PQQ is to the influence of Penaeus Vannmei rate of body weight gain, feed coefficient and survival rate
| PQQ addition mg/Kg | First starting weight (g) | 3 all rates of body weight gain (%) | 6 all rates of body weight gain (%) | 8 all rates of body weight gain (%) | Feed coefficient | Survival rate (%) |
| (0.0 1 group) 3.0 (2 groups) 6.0 (3 groups) 10.0 (4 groups) | 1.0±0.2 1.0±0.2 1.0±0.2 1.0±0.2 | 138.8±2.8 151.4±5.7 155.6±2.3 158.9±5.2 | 375.3±7.6 340.4±8.1 422.7±9.2 430.1±8.6 | 565.9±10.5 618.6±16.2 655.5±17.6 661.8±9.7? | 1.39±0.3 1.30±0.1 1.27±0.2 1.27±0.2 | 87.5±4.7 88.2±2.1 89.3±1.7 89.3±1.7 |
Rate of body weight gain (%)=(average end weighs-average initial weight)/average initial weight;
Shrimp mantissa during shrimp mantissa during survival rate (%)=off-test/on-test;
Feed coefficient=consumption feed gross weight/shrimp body weight gains
By result shown in the table 12 as can be known, along with the increase of PQQ addition in the feed, the rate of body weight gain of Penaeus Vannmei also has the trend of rising thereupon, and reaches the highest at 10mg/Kg when (8 week), each group weightening finish significant difference (P＜0.05).The feed coefficient of Penaeus Vannmei and survival rate do not have significant difference between each group.In the shrimp feed, add PQQ, can improve the production performance of prawn.
From above result of the test, can draw beneficial functional of the present invention and be: in fryer, pig, fish and shrimp, add feed addictive PQQ and can improve body weight gains and survival rate and the feed conversion rate of animal.The additive capacity of feed addictive PQQ in the cultivated animals feed is 0.1ppm-10ppm.But cultivated animals such as the feed addictive PQQ extensive use chicken that the present invention proposes, pig, fish, shrimp.
The feed that the present invention proposes adds the PQQ product that PQQ not only refers to adopt microbe fermentation method preparation production, also comprises the PQQ product by adopting chemical synthesis process and extract preparation production from natural plants simultaneously.
The feed addictive PQQ that the present invention proposes not only is applicable to the cultivated animals of mentioning among the present invention, also comprises other cultivated animals kind simultaneously.
Claims (6)
1. cultivated animals feed addictive, it is characterized in that: it is an active and effective with pyrroles's quinoline purine quinone, pyrroles's quinoline purine quinone English is pyrroloquinoline quinone, be called for short PQQ.
2. feed addictive according to claim 1 is characterized in that: described pyrroles's quinoline purine quinone PQQ is meant that the employing microbe fermentation method prepares the PQQ product of producing, the PQQ product that passes through to adopt the PQQ product of chemical synthesis process production or extraction preparation from natural plants.
3. feed addictive according to claim 1 is characterized in that: described feed addictive also contains carrier, and PQQ and carrier are re-dubbed final products; Described carrier can be mineral salt and/or carbon aqueous polymer, and wherein the weight content of carrier can be 30%-99%.
4. feed addictive according to claim 3 is characterized in that: described mineral salt is silica, calcium carbonate or zeolite; The carbon aqueous polymer is starch, dextrin, powdered glucose or corncob.
5. the application of the described feed addictive of claim 1 is characterized in that: described feed addictive can add in the cultivated animals feed, and described cultivated animals can be livestock and poultry, aquatic product animal and/or ruminates cultivated animals.
6. according to the application of the described feed addictive of claim 5, it is characterized in that: the PQQ that described feed addictive adds in feed proportion in feed is 0.1ppm---10.0ppm.
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| CN103621826A (en) * | 2013-11-28 | 2014-03-12 | 淮安正昌饲料有限公司 | Low-carbon environment-friendly conservation-stage piglet feed |
| CN103598484A (en) * | 2013-12-02 | 2014-02-26 | 中国农业科学院饲料研究所 | Forage additive for preventing egg-laying hen fatty liver syndrome and application thereof |
| CN106660843A (en) * | 2014-05-23 | 2017-05-10 | Nch公司 | Method for improving quality of aquaculture pond water |
| CN103960550A (en) * | 2014-05-29 | 2014-08-06 | 福建傲农生物科技集团有限公司 | Additive premixing feed for pig |
| CN103960550B (en) * | 2014-05-29 | 2016-05-04 | 福建傲农生物科技集团股份有限公司 | One boar additive premix |
| CN104644552B (en) * | 2015-02-06 | 2018-01-09 | 中国农业科学院饲料研究所 | Provisions tonic and its application in a kind of embryo of promotion growth of meat chicken |
| CN104644552A (en) * | 2015-02-06 | 2015-05-27 | 中国农业科学院饲料研究所 | Intra-embryonic provision tonic capable of promoting growth of broiler chicken and application of intra-embryonic provision tonic |
| CN106360000A (en) * | 2016-09-05 | 2017-02-01 | 常茂生物化学工程股份有限公司 | Application of pyrroloquinoline quinine active matter in prevention and control of weaned piglet diarrhea |
| CN107183385A (en) * | 2017-06-15 | 2017-09-22 | 福建傲农生物科技集团股份有限公司 | A kind of feed addictive for improving milking sow production performance and preparation method and application |
| WO2019202398A1 (en) * | 2018-04-20 | 2019-10-24 | Adisseo France S.A.S. | Feed additive for farmed animals |
| CN112004419A (en) * | 2018-04-20 | 2020-11-27 | 安迪苏法国联合股份有限公司 | Feed additive for breeding animals |
| CN116158498A (en) * | 2023-01-31 | 2023-05-26 | 南京农业大学 | Mitochondrial nutrient composition for improving sugar metabolism and preparation method and application thereof |
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