CN104397349A - Feeding intestinal tract sustained-release type compound acidifier and preparation method thereof - Google Patents
Feeding intestinal tract sustained-release type compound acidifier and preparation method thereof Download PDFInfo
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- CN104397349A CN104397349A CN201410609157.4A CN201410609157A CN104397349A CN 104397349 A CN104397349 A CN 104397349A CN 201410609157 A CN201410609157 A CN 201410609157A CN 104397349 A CN104397349 A CN 104397349A
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Abstract
The invention provides a feeding intestinal tract sustained-release type compound acidifier which comprises the following materials by weight percentage: 5-15 percent of lactic acid, 5-15 percent of anhydrous citric acid, 5-15 percent of fumaric acid, 3-8 percent of L-malic acid, 2-5 percent of sorbic acid, 3-8 percent of silicon dioxide, 1-8 percent of HPMCP (hydroxypropylmethyl cellulose phthalate), 0.5-1 percent of talcum powder and/or magnesium stearate and 30-50 percent of stearic acid and/or palmitic acid. The feeding intestinal tract sustained-release type compound acidifier has the effects of greatly reducing the using cost and efficiently replacing or reducing the usage of medicines and antibiotics in the livestock breeding process. The invention also provides a preparation method of the feeding intestinal tract sustained-release type compound acidifier.
Description
Technical field
The present invention relates to a kind of feeding intestinal sustained releasing type compound acidulant, also relate to a kind of preparation method of feeding intestinal sustained releasing type compound acidulant.
Background technology
Nowadays the problem of abuse of antibiotics more and more comes into one's own, and aquaculture is the severely afflicated area of abuse of antibiotics too.According to statistics, have many countries half in use antibiotic to be clinical for physianthropy in the world, half is then for livestock breeding industry.Allow people worry, if in aquaculture abuse of antibiotics, bring potential risk not only can to the safety of animal food, also can work the mischief to the health of the mankind and living environment.Therefore, a problem that can not be ignored in food security and animal husbandry sound development has been become to animal Using adapted Antibios.
In China, veterinary antibiotic is widely used in veterinary clinic and animal feeding, indispensable, but, in use also there are some problems that can not be ignored, such as blindly arbitrarily the situation such as medication, long-term excessive use is still outstanding, uses the phenomenon of forbidding antibiotic also to happen occasionally.Acidulant, as safety, environmental type feed addictive, has class antibiotic feature, is one of basic product of minimizing or alternative medicine and antibiotic usage.Compound acidulant has broad-spectrum antibacterial characteristic (as malic acid, sorbic acid) energy bactericidal on the one hand, on the other hand by reducing pH value in animal gastrointestinal tract, suppress harmful bacteria growth (as Escherichia coli, salmonella), promote beneficial bacterium increment (as Bacillus acidi lactici), promote animal health, reduce Animal diseases.
Present stage, intestinal sustained releasing type acidulant mostly was external product, and comply with one's wishes the producible Li Bian of large Leah scholar, and its complex manufacturing, use cost high (80 yuan ~ 120 yuan/kg), is difficult to promote the use of.
Summary of the invention
The present invention proposes a kind of feeding intestinal sustained releasing type compound acidulant, also proposed a kind of preparation method of feeding intestinal sustained releasing type compound acidulant, not only effect is remarkable, and greatly reduces use cost, efficiently can substitute or reduce livestock-raising process Chinese traditional medicine and antibiotic use.
Technical scheme of the present invention is achieved in that a kind of feeding intestinal sustained releasing type compound acidulant, by weight percentage, comprise following material: the fumaric acid of the lactic acid of 5-15%, the anhydrous citric acid of 5-15%, 5-15%, the L MALIC ACID of 3-8%, the sorbic acid of 2-5%, the silica of 3-8%, the HPMCP of 1-8%, the talcum powder of 0.5-1% and/or dolomol, the stearic acid of 30-50% and/or palmitic acid.
Preferably, by weight percentage, described feeding intestinal sustained releasing type compound acidulant comprises following material: the fumaric acid of the lactic acid of 5-10%, the anhydrous citric acid of 5-10%, 5-10%, the L MALIC ACID of 3-8%, the sorbic acid of 2-5%, the silica of 3-5%, the HPMCP of 1-8%, the talcum powder of 0.5-1% and/or dolomol, the stearic acid of 40-50% and/or palmitic acid.
Preferably, by weight percentage, described feeding intestinal sustained releasing type compound acidulant comprises following material: the lactic acid of 5%, the anhydrous citric acid of 15%, 15% fumaric acid, the L MALIC ACID of 8%, sorbic acid, the silica of 5%, the HPMCP of 1% of 2%, the talcum powder of 1% and/or dolomol, the stearic acid of 48% and/or palmitic acid.
Preferably, by weight percentage, described feeding intestinal sustained releasing type compound acidulant comprises following material: the lactic acid of 15%, the anhydrous citric acid of 10.5%, 5% fumaric acid, the L MALIC ACID of 3%, sorbic acid, the silica of 8%, the HPMCP of 3% of 5%, the talcum powder of 0.5% and/or dolomol, the stearic acid of 50% and/or palmitic acid.
Preferably, by weight percentage, described feeding intestinal sustained releasing type compound acidulant comprises following material: the lactic acid of 5%, the anhydrous citric acid of 15%, 15% fumaric acid, the L MALIC ACID of 8%, sorbic acid, the silica of 3%, the HPMCP of 8% of 5%, the talcum powder of 1% and/or dolomol, the stearic acid of 40% and/or palmitic acid.
A kind of preparation method of feeding intestinal sustained releasing type compound acidulant comprises the following steps:
Step 1: material prepares
Following raw material has been weighed: lactic acid, anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid, silica, HPMCP, talcum powder and/or dolomol, stearic acid and/or palmitic acid by formula rate;
Step 2: dissolve, pulverize, adsorb mixing, sieve
A) load weighted HPMCP is dissolved in the water, with for subsequent use;
B) load weighted stearic acid and/or palmitic acid and talcum powder and/or dolomol are dropped into hot melt in reaction pot to mix and be entirely packaging material, with for subsequent use;
C) anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid were pulverized 50 or 60 mesh sieves;
D) load weighted lactic acid atomization is sprayed into elder generation and powdered silica in mixer to adsorb, mix with anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid after completing, cross 50 or 60 mesh sieves, obtain mixed material;
Step 3: granulation, drying
A) open rotating pelletizer, rotary speed 80-100r/min is set, EAT 65-75 DEG C is set;
B) mixed material is dropped in rotating pelletizer;
C) arranging peristaltic pump rotating speed is 25-35r/min, spray gun pressure 1-2mpa, sprays into the HPMCP aqueous solution, and uniform atomizing is on material surface;
D) after 5-8 minute, after the HPMCP aqueous solution has sprayed and has single-size to be formed, adjustment EAT has been 85-90 DEG C, adjustment rotary speed 30-40r/min, dry 10-30min;
E) time to be dried arrives, and after material uniform loose, blowing crosses 30-80 order classifying screen;
F) upper and screenings are sieved in removal, obtain semi-finished product;
Step 4: end spray fluidized bed coating
A) semi-finished product are laid in fluidized-bed bottom, open fluid bed, blower fan frequency 28-45HZ is set, EAT 40 DEG C-50 DEG C, spray gun pressure 2.5-3mPA, thimble pressure 3-3.5mPA, automatic ash removing 2-3S/ time;
B) preheated fluidification seed-coating machine 10-15min, and simultaneously preheating spray gun 1, spray gun 2, spray gun 3, preheating time 10-15min;
C) after preheating, connect spray gun 1-3, open peristaltic pump power supply, peristaltic pump rotating speed 50-100r/min is set, the packaging material in reaction pot is sprayed in fluid bed;
F) after material cooling 3-8min, blowing crosses 20-80 order classifying screen, detects qualified rear packaging warehouse-in.
Preferably, the preparation method of described feeding intestinal sustained releasing type compound acidulant, comprises the following steps:
Step 1: material prepares
Following raw material has been weighed: lactic acid, anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid, silica, HPMCP, talcum powder and/or dolomol, stearic acid and/or palmitic acid by formula rate;
Step 2: dissolve, pulverize, adsorb mixing, sieve
A) load weighted HPMCP is dissolved in the water, with for subsequent use;
B) load weighted stearic acid and/or palmitic acid and talcum powder and/or dolomol are dropped into hot melt in reaction pot to mix and be entirely packaging material, with for subsequent use;
C) anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid were pulverized 60 mesh sieves;
D) load weighted lactic acid atomization is sprayed into elder generation and powdered silica in mixer to adsorb, mix with anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid after completing, cross 60 mesh sieves, obtain mixed material;
Step 3: granulation, drying
A) open rotating pelletizer, rotary speed 90-100r/min is set, EAT 70-75 DEG C is set;
B) mixed material is dropped in rotating pelletizer;
C) arranging rotating pelletizer rotating speed is 30r/min, spray gun pressure 1-2mpa, sprays into the HPMCP aqueous solution, and uniform atomizing is on material surface;
D) after 5-8 minute, after the HPMCP aqueous solution has sprayed and has single-size to be formed, adjustment EAT has been 85-90 DEG C, adjustment rotary speed 35-40r/min, dry 20-30min;
E) time to be dried arrives, and after material uniform loose, blowing crosses 30-80 order classifying screen;
F) upper and screenings are sieved in removal, obtain semi-finished product;
Step 4: end spray fluidized bed coating
A) semi-finished product are laid in fluidized-bed bottom, open fluid bed, blower fan frequency 38-45HZ is set, EAT 45 DEG C-50 DEG C, spray gun pressure 2.5-3mPA, thimble pressure 3-3.2mPA, automatic ash removing 3S/ time;
B) preheated fluidification seed-coating machine 12-15min, and simultaneously preheating spray gun 1, spray gun 2, spray gun 3, preheating time 12-15min;
C) after preheating, connect spray gun 1-3, open peristaltic pump power supply, peristaltic pump rotating speed 80-100r/min is set, the packaging material in reaction pot is sprayed in fluid bed;
F) after material cooling 3-8min, blowing crosses 20-80 order classifying screen, detects qualified rear packaging warehouse-in.
Advantageous Effects of the present invention is: feeding intestinal sustained releasing type compound acidulant substitutes or one of basic product reducing livestock-raising process Chinese traditional medicine and antibiotic usage, there is the features such as safety, green, efficient, environmental protection, use the problem that can greatly reduce breeding process Chinese traditional medicine and abuse of antibiotics and remain.
Add to after in feed and do not produce acid-base reaction with basic materials (as stone flour, trace element, sodium bicarbonate etc.), do not damage the nutritional labeling in feed.Pig farm foul smell can be reduced, improve nitrogen phosphorus digestibility, purification feeding environment.
Cross stomach arrival duodenum and start slow releasing, slowly-releasing reaches 3 ~ 5 hours, long action time, active area is wide, can not only direct bactericidal, and by the slow releasing of acid ion, regulate and reduce animal intestinal environment pH value, suppress harmful bacteria growth, promote beneficial bacterium propagation.Pathogenic bacteria the most suitable growth environmental pH as most of in Escherichia coli, salmonella etc. is 6.5 ~ 8.0, and the beneficial bacterium the most suitable growth environmental pH such as Bacillus acidi lactici are 5.5 ~ 6.0, therefore can effectively suppress pathogenic bacteria to grow by slowly-releasing regulation and control intestinal environment pH, support beneficial bacterium is bred, and promotes livestock and poultry animal healthy growth.
Described feeding intestinal sustained releasing type compound acidulant preparation method does not destroy its nutritional labeling, is easy to apply.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is the PH change curve of the aqueous solution of a kind of feeding intestinal sustained releasing type compound acidulant of the present invention embodiment.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
According to content provided by the invention, inventor obtains feeding intestinal sustained releasing type compound acidulant 1, material proportion by weight percentage and preparation process as follows:
Material proportion: the lactic acid of 5%, the anhydrous citric acid of 15%, 15% fumaric acid, the L MALIC ACID of 8%, sorbic acid, the silica of 5%, the HPMCP of 1% of 2%, the talcum powder of 1%, the stearic acid of 48%.
By said ratio, the preparation method of feeding intestinal sustained releasing type compound acidulant 1 is as follows:
Step 1: material prepares
Following raw material has been weighed: lactic acid, anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid, silica, HPMCP, talcum powder, stearic acid by formula rate;
Step 2: dissolve, pulverize, adsorb mixing, sieve
A) load weighted HPMCP is dissolved in the water, with for subsequent use;
B) load weighted stearic acid and talcum powder are dropped into hot melt in reaction pot to mix and be entirely packaging material, with for subsequent use;
C) anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid were pulverized 50 mesh sieves;
D) load weighted lactic acid atomization is sprayed into elder generation and powdered silica in mixer to adsorb, mix with anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid after completing, cross 50 mesh sieves, obtain mixed material;
Step 3: granulation, drying
A) open rotating pelletizer, rotary speed 80r/min is set, EAT 65 DEG C is set;
B) mixed material is dropped in rotating pelletizer;
C) arranging rotating pelletizer rotating speed is 25r/min, spray gun pressure 1mpa, sprays into the HPMCP aqueous solution, and uniform atomizing is on material surface;
D) after 5 minutes, after the HPMCP aqueous solution has sprayed and has single-size to be formed, adjustment EAT has been 85 DEG C, adjustment rotary speed 30r/min, dry 10min;
E) time to be dried arrives, and after material uniform loose, blowing crosses 30-80 order classifying screen;
F) upper and screenings are sieved in removal, obtain semi-finished product;
Step 4: end spray fluidized bed coating
A) semi-finished product are laid in fluidized-bed bottom, open fluid bed, blower fan frequency 28-45HZ is set, EAT 40 DEG C, spray gun pressure 2.5mPA, thimble pressure 3mPA, automatic ash removing 2S/ time;
B) preheated fluidification seed-coating machine 10min, and simultaneously preheating spray gun 1, spray gun 2, spray gun 3, preheating time 10min;
C) after preheating, connect spray gun 1-3, open peristaltic pump power supply, peristaltic pump rotating speed 50r/min is set, the packaging material in reaction pot is sprayed in fluid bed;
F) after material cooling 3min, blowing crosses 20-80 order classifying screen, obtains feeding intestinal sustained releasing type compound acidulant 1.
Embodiment 2
According to content provided by the invention, inventor obtains feeding intestinal sustained releasing type compound acidulant 2, material proportion by weight percentage and preparation process as follows:
Material proportion: the lactic acid of 15%, the anhydrous citric acid of 10.5%, 5% fumaric acid, the L MALIC ACID of 3%, sorbic acid, the silica of 8%, the HPMC of 3% of 5%, the dolomol of 0.5%, the palmitic acid of 50%.
By said ratio, the preparation method of feeding intestinal sustained releasing type compound acidulant 2 is as follows:
Step 1: material prepares
Following raw material has been weighed: lactic acid, anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid, silica, HPMC, dolomol, palmitic acid by formula rate;
Step 2: dissolve, pulverize, adsorb mixing, sieve
A) load weighted HPMC is dissolved in the water, with for subsequent use;
B) load weighted palmitic acid and dolomol are dropped into hot melt in reaction pot to mix and be entirely packaging material, with for subsequent use;
C) anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid were pulverized 60 mesh sieves;
D) load weighted lactic acid atomization is sprayed into elder generation and powdered silica in mixer to adsorb, mix with anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid after completing, cross 60 mesh sieves, obtain mixed material;
Step 3: granulation, drying
A) open rotating pelletizer, rotary speed 100r/min is set, EAT 75 DEG C is set;
B) mixed material is dropped in rotating pelletizer;
C) arranging rotating pelletizer rotating speed is 35r/min, spray gun pressure 2mpa, sprays into the HPMC aqueous solution, and uniform atomizing is on material surface;
D) after 8 minutes, after the HPMC aqueous solution has sprayed and has single-size to be formed, adjustment EAT has been 90 DEG C, adjustment rotary speed 40r/min, dry 30min;
E) time to be dried arrives, and after material uniform loose, blowing crosses 30-80 order classifying screen;
F) upper and screenings are sieved in removal, obtain semi-finished product;
Step 4: end spray fluidized bed coating
A) semi-finished product are laid in fluidized-bed bottom, open fluid bed, blower fan frequency 28-45HZ is set, EAT 50 DEG C, spray gun pressure 3mPA, thimble pressure 3.5mPA, automatic ash removing 3S/ time;
B) preheated fluidification seed-coating machine 15min, and simultaneously preheating spray gun 1, spray gun 2, spray gun 3, preheating time 15min;
C) after preheating, connect spray gun 1-3, open peristaltic pump power supply, peristaltic pump rotating speed 100r/min is set, the packaging material in reaction pot is sprayed in fluid bed;
F) after material cooling 5min, blowing crosses 20-80 order classifying screen, obtains feeding intestinal sustained releasing type compound acidulant 2.
Embodiment 3
According to content provided by the invention, inventor obtains feeding intestinal sustained releasing type compound acidulant 2, material proportion by weight percentage and preparation process as follows:
Material proportion: the lactic acid of 5%, the anhydrous citric acid of 15%, 15% fumaric acid, the L MALIC ACID of 8%, sorbic acid, the silica of 3%, the HPMCP of 8% of 5%, the talcum powder of 0.5%, the dolomol of 0.5%, the stearic acid of 20%, the palmitic acid of 20%.
By said ratio, the preparation method of feeding intestinal sustained releasing type compound acidulant 3 is as follows:
Step 1: material prepares
Following raw material has been weighed: lactic acid, anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid, silica, HPMCP, talcum powder, dolomol, stearic acid, palmitic acid by formula rate;
Step 2: dissolve, pulverize, adsorb mixing, sieve
A) load weighted HPMCP is dissolved in the water, with for subsequent use;
B) load weighted stearic acid, palmitic acid, talcum powder, dolomol are dropped into hot melt mixing in reaction pot and be entirely packaging material, with for subsequent use;
C) anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid were pulverized 60 mesh sieves;
D) load weighted lactic acid atomization is sprayed into elder generation and powdered silica in mixer to adsorb, mix with anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid after completing, cross 60 mesh sieves, obtain mixed material;
Step 3: granulation, drying
A) open rotating pelletizer, rotary speed 90r/min is set, EAT 70 DEG C is set;
B) mixed material is dropped in rotating pelletizer;
C) arranging rotating pelletizer rotating speed is 30r/min, spray gun pressure 1mpa, sprays into the aqueous solution of HPMCP, and uniform atomizing is on material surface;
D), after 6 minutes, after the aqueous solution of HPMCP has sprayed and has single-size to be formed, adjustment EAT has been 87 DEG C, adjustment rotary speed 35r/min, dry 20min;
E) time to be dried arrives, and after material uniform loose, blowing crosses 30-80 order classifying screen;
F) upper and screenings are sieved in removal, obtain semi-finished product;
Step 4: end spray fluidized bed coating
A) semi-finished product are laid in fluidized-bed bottom, open fluid bed, blower fan frequency 28-45HZ is set, EAT 45 DEG C, spray gun pressure 2.7mPA, thimble pressure 3.3mPA, automatic ash removing 3S/ time;
B) preheated fluidification seed-coating machine 12.5min, and simultaneously preheating spray gun 1, spray gun 2, spray gun 3, preheating time 12.5min;
C) after preheating, connect spray gun 1-3, open peristaltic pump power supply, peristaltic pump rotating speed 80r/min is set, the packaging material in reaction pot is sprayed in fluid bed;
F) after material cooling 4min, blowing crosses 20-80 order classifying screen, obtains feeding intestinal sustained releasing type compound acidulant 3.
Experiment 1:
The feeding intestinal sustained releasing type compound acidulant 1 obtained, feeding intestinal sustained releasing type compound acidulant 2, feeding intestinal sustained releasing type compound acidulant 3 have been done following slowly-releasing experiment by inventor:
SR test method: by 1g common acids agent and 1g intestinal sustained releasing type compound acidulant 1, be placed in the beaker of 99g deionized water respectively, leaves standstill every 30min, reading both measuring with laboratory pH meter.Be abscissa with time, take pH value as ordinate curve plotting, the result obtained as shown in Figure 1.
As shown in Figure 1,1% pH value of water solution of intestinal sustained releasing type compound acidulant 1 can slowly decline in 3-8 hour, and slow release effect is splendid, and after the molten water of common acids agent, pH value is not any change and slow release effect.
Inventor have also been made above-mentioned SR test with feeding intestinal sustained releasing type compound acidulant 2, feeding intestinal sustained releasing type compound acidulant 3, and result is also similar with above-mentioned experimental result.
Experiment 2
The feeding intestinal sustained releasing type compound acidulant 1 obtained, feeding intestinal sustained releasing type compound acidulant feeding intestinal sustained releasing type compound acidulant 3 have been done following raising experiment by inventor:
2.1 test materials: feeding intestinal sustained releasing type compound acidulant 1
2.2 experimental animals and grouping
Select age in days to differ and be no more than the weanling pig 180 that 3d, weight differences are remarkable, kind is identical, identical according to genetic background, that body weight is close, sex ratio is consistent principle is divided into 2 large group at random, often organize 90 weanling pigs, be respectively control group and test group.
2.3 test daily ration and Treatment Design
With reference to U.S. NRC weanling pig nutrition requirements and in conjunction with production practices preparation basal diet.Control group piglet is identical with test group piglet basal diet, wherein control group pig starter feed adds Chlortetracycline premix 100g/ ton feed, do not add intestinal sustained releasing type compound acidulant, test group pig starter feed adds 1000g feeding intestinal sustained releasing type compound acidulant 1/ ton of feed, does not add Chlortetracycline premix.
2.4 feedings and managements and epidemic prevention
This test preliminary trial period 2d, is just trying phase 28d.Test is carried out at same conservation pigsty, cleans thoroughly and sterilizes, carry out whole audience epidemic prevention to whole pigsty to test pig house used.Test according to pig farm normal procedure (25 ~ 35 age in days) injecting swine fever vaccine, triple vaccine (55 ~ 75 age in days), and carries out expelling parasite.Check the implementation of conditions of pig house, apparatus, isolation house, fecaluria process and piggery enviroment health.Piglet free choice feeding and drinking-water, feed day 3 times (morning seven point, afternoon a bit, evening seven point), every day accurate recording piglet feed intake.
2.5 results and analysis
Table 1 adds the impact of feeding intestinal sustained releasing type compound acidulant 1 on Growth Performance of Weaning Piglets
Note: having common superscript letter person difference not remarkable with column mean, is different Superscript letters person significant differences with column mean.
As shown in Table 1, the test group piglet of feeding intestinal sustained releasing type compound acidulant 1 is with the addition of compared with the control group piglet that with the addition of Chlortetracycline premix in pig starter feed in pig starter feed, test group piglet is all high than control group piglet in daily ingestion amount, daily gain, feedstuff-meat ratio is low, wherein in daily gain, test group piglet improves 26.92% compared with control group piglet
Table 2 adds the impact of feeding intestinal sustained releasing type compound acidulant 1 on Gastrointestinal Tract of Weanling Piglets Chyme pH
Note: having common superscript letter person difference not remarkable with column mean, is different Superscript letters person significant differences with column mean.
As shown in Table 2, in test group piglet stomach, the reduction more remarkable in control group of the pH value of chyme, reduces 11.47%.
Table 3 adds the impact of feeding intestinal sustained releasing type compound acidulant 1 on diarrhea of weaned piglets situation
Note: having common superscript letter person difference not remarkable with column mean, is different Superscript letters person significant differences with column mean.
As shown in Table 3, the diarrhea rate of test group piglet, significantly lower than control group piglet, reduces 30.12%, illustrates that the test group of adding feeding intestinal sustained releasing type compound acidulant 1 significantly can reduce the diarrhea rate of piglet than control group.
Inventor have also been made identical animal experiment with feeding intestinal sustained releasing type compound acidulant 2, feeding intestinal sustained releasing type compound acidulant 3, also can draw above-mentioned similar result.
To sum up interpretation of result, add a certain amount of feeding intestinal sustained releasing type compound acidulant in early days in weanling pig daily ration, piglet daily gain and feed intake can be improved, reduce the feedstuff-meat ratio of piglet, simultaneously in reduction diarrhea rate, also there is remarkable result, can the interpolation of substitute antibiotics use.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (7)
1. a feeding intestinal sustained releasing type compound acidulant, it is characterized in that: by weight percentage, comprise following material: the fumaric acid of the lactic acid of 5-15%, the anhydrous citric acid of 5-15%, 5-15%, the L MALIC ACID of 3-8%, the sorbic acid of 2-5%, the silica of 3-8%, the HPMCP of 1-8%, the talcum powder of 0.5-1% and/or dolomol, the stearic acid of 30-50% and/or palmitic acid.
2. feeding intestinal sustained releasing type compound acidulant as claimed in claim 1, it is characterized in that: by weight percentage, comprise following material: the fumaric acid of the lactic acid of 5-10%, the anhydrous citric acid of 5-10%, 5-10%, the L MALIC ACID of 3-8%, the sorbic acid of 2-5%, the silica of 3-5%, the HPMCP of 1-8%, the talcum powder of 0.5-1% and/or dolomol, the stearic acid of 40-50% and/or palmitic acid.
3. feeding intestinal sustained releasing type compound acidulant as claimed in claim 1, it is characterized in that: by weight percentage, comprise following material: the lactic acid of 5%, the anhydrous citric acid of 15%, 15% fumaric acid, the L MALIC ACID of 8%, sorbic acid, the silica of 5%, the HPMCP of 1% of 2%, the talcum powder of 1% and/or dolomol, the stearic acid of 48% and/or palmitic acid.
4. feeding intestinal sustained releasing type compound acidulant as claimed in claim 1, it is characterized in that: by weight percentage, comprise following material: the lactic acid of 15%, the anhydrous citric acid of 10.5%, 5% fumaric acid, the L MALIC ACID of 3%, sorbic acid, the silica of 8%, the HPMCP of 3% of 5%, the talcum powder of 0.5% and/or dolomol, the stearic acid of 50% and/or palmitic acid.
5. feeding intestinal sustained releasing type compound acidulant as claimed in claim 1, it is characterized in that: by weight percentage, comprise following material: the lactic acid of 5%, the anhydrous citric acid of 15%, 15% fumaric acid, the L MALIC ACID of 8%, sorbic acid, the silica of 3%, the HPMCP of 8% of 5%, the talcum powder of 1% and/or dolomol, the stearic acid of 40% and/or palmitic acid.
6. the preparation method of feeding intestinal sustained releasing type compound acidulant as claimed in claim 1, is characterized in that comprising the following steps:
Step 1: material prepares
Following raw material has been weighed: lactic acid, anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid, silica, HPMCP, talcum powder and/or dolomol, stearic acid and/or palmitic acid by formula rate;
Step 2: dissolve, pulverize, adsorb mixing, sieve
A) load weighted HPMCP is dissolved in the water, with for subsequent use;
B) load weighted stearic acid and/or palmitic acid and talcum powder and/or dolomol are dropped into hot melt in reaction pot to mix and be entirely packaging material, with for subsequent use;
C) anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid were pulverized 50 or 60 mesh sieves;
D) load weighted lactic acid atomization is sprayed into elder generation and powdered silica in mixer to adsorb, mix with anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid after completing, cross 50 or 60 mesh sieves, obtain mixed material;
Step 3: granulation, drying
A) open rotating pelletizer, rotary speed 80-100r/min is set, EAT 65-75 DEG C is set;
B) mixed material is dropped in rotating pelletizer;
C) arranging peristaltic pump rotating speed is 25-35r/min, spray gun pressure 1-2mpa, sprays into the HPMCP aqueous solution, and uniform atomizing is on material surface;
D) after 5-8 minute, after the HPMCP aqueous solution has sprayed and has single-size to be formed, adjustment EAT has been 85-90 DEG C, adjustment rotary speed 30-40r/min, dry 10-30min;
E) time to be dried arrives, and after material uniform loose, blowing crosses 30-80 order classifying screen;
F) upper and screenings are sieved in removal, obtain semi-finished product;
Step 4: end spray fluidized bed coating
A) semi-finished product are laid in fluidized-bed bottom, open fluid bed, blower fan frequency 28-45HZ is set, EAT 40 DEG C-50 DEG C, spray gun pressure 2.5-3mPA, thimble pressure 3-3.5mPA, automatic ash removing 2-3S/ time;
B) preheated fluidification seed-coating machine 10-15min, and simultaneously preheating spray gun 1, spray gun 2, spray gun 3, preheating time 10-15min;
C) after preheating, connect spray gun 1-3, open peristaltic pump power supply, peristaltic pump rotating speed 50-100r/min is set, the packaging material in reaction pot is sprayed in fluid bed;
F) after material cooling 3-8min, blowing crosses 20-80 order classifying screen, detects qualified rear packaging warehouse-in.
7. the preparation method of feeding intestinal sustained releasing type compound acidulant as claimed in claim 6, is characterized in that comprising the following steps:
Step 1: material prepares
Following raw material has been weighed: lactic acid, anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid, silica, HPMCP, talcum powder and/or dolomol, stearic acid and/or palmitic acid by formula rate;
Step 2: dissolve, pulverize, adsorb mixing, sieve
A) load weighted HPMCP is dissolved in the water, with for subsequent use;
B) load weighted stearic acid and/or palmitic acid and talcum powder and/or dolomol are dropped into hot melt in reaction pot to mix and be entirely packaging material, with for subsequent use;
C) anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid were pulverized 60 mesh sieves;
D) load weighted lactic acid atomization is sprayed into elder generation and powdered silica in mixer to adsorb, mix with anhydrous citric acid, fumaric acid, L MALIC ACID, sorbic acid after completing, cross 60 mesh sieves, obtain mixed material;
Step 3: granulation, drying
A) open rotating pelletizer, rotary speed 90-100r/min is set, EAT 70-75 DEG C is set;
B) mixed material is dropped in rotating pelletizer;
C) arranging rotating pelletizer rotating speed is 30r/min, spray gun pressure 1-2mpa, sprays into the HPMCP aqueous solution, and uniform atomizing is on material surface;
D) after 5-8 minute, after the HPMCP aqueous solution has sprayed and has single-size to be formed, adjustment EAT has been 85-90 DEG C, adjustment rotary speed 35-40r/min, dry 20-30min;
E) time to be dried arrives, and after material uniform loose, blowing crosses 30-80 order classifying screen;
F) upper and screenings are sieved in removal, obtain semi-finished product;
Step 4: end spray fluidized bed coating
A) semi-finished product are laid in fluidized-bed bottom, open fluid bed, blower fan frequency 38-45HZ is set, EAT 45 DEG C-50 DEG C, spray gun pressure 2.5-3mPA, thimble pressure 3-3.2mPA, automatic ash removing 3S/ time;
B) preheated fluidification seed-coating machine 12-15min, and simultaneously preheating spray gun 1, spray gun 2, spray gun 3, preheating time 12-15min;
C) after preheating, connect spray gun 1-3, open peristaltic pump power supply, peristaltic pump rotating speed 80-100r/min is set, the packaging material in reaction pot is sprayed in fluid bed;
F) after material cooling 3-8min, blowing crosses 20-80 order classifying screen, detects qualified rear packaging warehouse-in.
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