CN102106461A - Enveloping acidifier for feed and preparation method thereof - Google Patents
Enveloping acidifier for feed and preparation method thereof Download PDFInfo
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- CN102106461A CN102106461A CN2010106224173A CN201010622417A CN102106461A CN 102106461 A CN102106461 A CN 102106461A CN 2010106224173 A CN2010106224173 A CN 2010106224173A CN 201010622417 A CN201010622417 A CN 201010622417A CN 102106461 A CN102106461 A CN 102106461A
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Abstract
The invention relates to enveloping acidifier and the preparation method thereof. The enveloping acidifier comprises acidifier solid microparticles and an enveloping layer on the surface of the acidifier solid microparticles, wherein the enveloping layer comprises an ethyecellulose (EC) and hydroxypropyl methyl cellulose (HPMC) composite layer and an enteric-coated polyacrylic resin layer. In the invention, sustained-release coating material with good film forming property and the coating process are adopted, so that excessive enveloping material consumption is avoided, the weight of the acidifier solid microparticles is increased slightly, the large total effective acid of the acidifier is kept, and the acidifier has good sustained-release effect.
Description
Technical field
The present invention relates to field of feed additive technology, specifically, relate to a kind of feed with wrapping by acidulant and preparation method thereof.
Background technology
Acidulant is a kind of common animal feed additive, can reduce feed is sour power, suppress in the feed and the interior growth that is harmful to bacterium of animal alimentary canal, and keep microbiotic balance in the animal animal alimentary canal, improve the digestibility of feed nutrition material, reduce the particularly diarrhoea of young animal of animal, and improve the immunity of animal body.Improve the growth performance of animal.
At present common acidulant is based on compound acidulant, its main component be various organic acids such as lactic acid, citric acid, fumaric acid, propionic acid, malic acid, sorbic acid, formic acid etc. with inorganic acid such as phosphoric acid according to the composite mixture that forms of certain ratio.
Acidulant has a series of advantages in animal produces, but in use also exist some problems at present, mainly comprise: common acidulant is absorbed too fast by the animal alimentary canal in animal body, major part promptly is absorbed under one's belt, seldom can arrive back segment alimentary canals such as animal small intestine, fully antibacterial the and growth promoting function of performance in metenteron; Some alkaline active materials react in common acidulant and the feed, and it is caused certain destruction; Common acidulant wants to bring into play it and should produce effect, and usually bigger addition need be arranged in feed, has increased feed cost.
In order to make acidulant performance acidifying and bacteriostasis in animal alimentary canal better; people have carried out a series of researchs to the release tech that delays of acidulant in recent years; wherein coating technique is that outer surface at common compound acidulant superscribes the specific protective layer of one deck by suitable art for coating; the active ingredient of acidulant can be discharged lentamente along with the dissolving of clothing film in the alimentary canal of animal, and reduce in feed the reaction with other composition.
The capsulating material that bag is used always by acidulant has fat, aliphatic acid and other common bag by auxiliary material etc., usually adopt the technology of melt coating, these solid matters fusing backs are sprayed onto solid particles surface in the mode of spraying or be pre-mixed after carry out spraying granulation.
Use above-mentioned melt coating method, the consumption of capsulating material fat and aliphatic acid is generally bigger, reached more than 40% by the consumption of capsulating materials such as acidulant capsulating material stearic acid and beta-schardinger dextrin-as the disclosed bag of CN200710029691, having caused bag on the low side by the content of the total effective acid of acidulant, is 45～53% as the disclosed bag of CN200310106338 by acidulant organic acid total amount.
At above-mentioned defective, the present invention utilizes film forming commonly used in the medicine sustained release coating material and art for coating preferably, has proposed a kind of novel bag by acidulant, and has provided its preparation method.
Summary of the invention
The purpose of this invention is to provide a kind of bag by acidulant and preparation method thereof.
The present invention adopts film forming commonly used in the medicine sustained release coating material and art for coating preferably, can exceed the consumption capsulating material, the weightening finish of acidulant solid particle is less, thereby makes acidulant keep bigger effective acid total amount, has slow release effect preferably simultaneously.
Bag of the present invention is comprised the bag tegillum on acidulant solid microparticle and acidulant solid microparticle surface by acidulant, and described acidulant solid microparticle comprises the component of following parts by weight: lactic acid: 20～30 parts; Fumaric acid: 5～15 parts; Citric acid: 10～15 parts; Malic acid: 5～10 parts; Formic acid: 5～10 parts; Propionic acid: 5～10 parts; Silica: 25～30 parts; 2～3 parts of synergist.
Described bag tegillum comprises ethyl cellulose and hydroxypropyl methylcellulose composite bed, and the quality of described ethyl cellulose and the compound coatings of hydroxypropyl methylcellulose is 2%～4% of an acidulant solid microparticle quality.。
The compound coatings of described ethyl cellulose and hydroxypropyl methylcellulose comprises ethyl cellulose and hydroxypropyl methylcellulose, and wherein the weight ratio of ethyl cellulose and hydroxypropyl methylcellulose is 1: 1～2.5;
In addition, outside described ethyl cellulose and hydroxypropyl methylcellulose composite bed, described bag tegillum also comprises enteric solubility polyacrylic resin layer; Generally, this area enteric solubility polyacrylic resin commonly used has polyacrylic resin number, III number etc.Described enteric solubility polyacrylic resin coatings comprises the enteric solubility polyacrylic resin, and the quality of described enteric solubility polyacrylic resin coatings is 2%～3% of an acidulant solid microparticle quality.
In addition, also comprise following one or more dressing additives in described enteric solubility polyacrylic resin coatings and described ethyl cellulose and the compound coatings of hydroxypropyl methylcellulose: caking inhibiter, dispersant, plasticizer and defoamer.The quality of described dressing additive is 10%～50% of its affiliated coatings quality.
Above-mentioned dressing additive is to add for the character such as firm, smooth that guarantees dressing, can select configuration packet clothing various additives commonly used for use, can select polyethylene glycol for use as caking inhibiter; Dispersant can be selected talcum powder, dolomol, titanium dioxide etc. for use; Plasticizer can be selected polyethylene glycol, propane diols, triethyl citrate etc. for use; Defoamer can be selected methyl-silicone oil etc. for use;
Described synergist is probiotics or origanum oil.Wherein, described microorganism formulation is this area probiotics commonly used, as Bacillus acidi lactici, bacillus subtilis formulation etc.
The present invention also provides above-mentioned bag by the preparation method of acidulant, and the present invention adopts macromolecular materials such as sustained-release matrix material and PH sensitive material, takes double-deck coating technique, makes bag by acidulant.
Described preparation method comprises the steps:
(1) lactic acid, fumaric acid, citric acid, malic acid, formic acid, propionic acid are mixed stirring, then the liquid that mixes is sprayed in the mixer that carrier silica is housed, fully mix, sneak into synergist then, obtain acidulant solid microparticle;
(2) mixed solid microparticle is added efficient fluidized-bed coating machine, under fluidized state, spray into ethyl cellulose and hydroxypropyl methylcellulose composite slow release framework material coating solution A wraps quilt, spray into enteric solubility polyacrylic resin coating solution B after having sprayed again with atomize.Wherein the weight of coating solution A is 30～50% of step (1) gained acidulant powder, and the weight of coating solution B is 50～70% of step (1) gained acidulant powder, obtains bag of the present invention by acidulant.
Wherein: described coating solution A comprises that ethyl cellulose, hydroxypropyl methylcellulose, solvent and one or more comprise the dressing additive of caking inhibiter, dispersant, plasticizer and defoamer; Wherein the mass ratio of ethyl cellulose, hydroxypropyl methylcellulose, solvent and dressing additive is: 1: 1～2.5: 55～80: 0.8～2.0;
Described coating solution B comprises that enteric solubility polyacrylic resin, solvent and one or more comprise the dressing additive of caking inhibiter, dispersant, plasticizer and defoamer; Wherein the mass ratio of enteric solubility polyacrylic resin, solvent and dressing additive is: 1: 10～35: 0.5～2.0;
Described solvent is water and/or absolute ethyl alcohol.
Subsequently the solid particle that makes being crossed the packing of weighing behind the screen cloth (20 order) gets product.
Concrete, described coating solution A can adopt following prescription: ethyl cellulose 1.5kg, and hydroxypropyl methylcellulose 1.5kg, PEG-60001kg, talcum powder 1kg, 95% ethanol 50kg, water 45kg, 100 mesh sieves are crossed promptly in the back that stirs.
Described coating solution B adopts following prescription polyacrylic resin 2.5kg, polyacrylic resin 2.5kg, and 95% ethanol 80kg, water 10kg, talcum powder 2kg, triethyl citrate 0.5kg, methyl-silicone oil 10ml, 100 mesh sieves were crossed promptly in the back that stirred.
For guaranteeing to mix, adopted liquid mixture to spray in the solid silica among the present invention, but be not limited to this kind method with atomize with various acid.
Detect and find; this bag is by the acidulant product bag average out to 5～6% that increased weight; the total effective acid content in back reaches more than 60% after testing; in addition; should wrap by acidulant and mix the back sealing with sodium bicarbonate solid; the bag phenomenon that expands do not occur in 48h, show its effective acid protection fully, the dressing sealing effectiveness is good.
After this bag is entered in the animal body by acidulant, in the gastral low pH environment of leading portion, wrap comparatively completely by the acidulant coating membrane, effective acid composition major part does not discharge.After arriving the metenteron of higher pH value, the dissolving of outer pH sensitive material coating membrane is broken, and the effective acid composition slowly releases by internal layer sustained-release matrix material, and performance is antibacterial and improve the effect of the little ecology of animal alimentary canal in whole metenteron.
Compared with prior art, the present invention has following advantage:
(1) adopt double-deck coating technique, total effective acid content height can reach more than 60% after after testing.
(2) capsulating material has the better protect effect to the active ingredient organic acid of acidulant.
The specific embodiment
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.Specialize as nothing, the raw material that present embodiment adopts is commercial.
Embodiment 1
30kg lactic acid, 10kg fumaric acid, 10kg citric acid, 9kg formic acid, 7kg propionic acid, 5kg malic acid are mixed stirring, the liquid that mixes is sprayed in the 29kg carrier silica then, fully mix, sneak into synergist probiotics (available from the very lucky feed corporation,Ltd in Jinan, intestines are peaceful and comfortable) 3kg then.
Mixed solid microparticle is added efficient fluidized-bed coating machine, under fluidized state, spray into compound coating solution A of 50kg ethyl cellulose and hydroxypropyl methylcellulose and 50kg enteric solubility polyacrylic resin coating solution B successively and wrap and granulated.
Wherein, coating solution A preparation technology is: ethyl cellulose 1.5kg, and hydroxypropyl methylcellulose 1.5kg, PEG-60001kg, talcum powder 1kg, 95% ethanol 50kg, water 45kg, the back that stirs is crossed 100 mesh sieves and is coating solution A; Coating solution B preparation technology is: polyacrylic resin 2.5kg, and polyacrylic resin 2.5kg, 95% ethanol 80kg, water 10kg, talcum powder 2kg, triethyl citrate 0.5kg, methyl-silicone oil 10ml, the back that stirs is crossed 100 mesh sieves and is coating solution B.
The solid particle that makes is crossed the packing of weighing behind 20 eye mesh screens to get product.
The back total acid content is 60.7% after testing, moisture≤8%.
Embodiment 2
25kg lactic acid, 12kg fumaric acid, 11kg citric acid, 10kg formic acid, 7kg propionic acid, 5kg malic acid are mixed stirring, the liquid that mixes is sprayed in the 30kg carrier silica then, fully mix, sneak into synergist probiotics (, adding the bacterium benefit) 3kg then available from the very lucky feed corporation,Ltd in Jinan.
Mixed solid microparticle is added efficient fluidized-bed coating machine, under fluidized state, spray into compound coating solution A of 40kg ethyl cellulose and hydroxypropyl methylcellulose and 60kg enteric solubility polyacrylic resin coating solution B successively and wrap and granulated.
Wherein, coating solution A preparation technology is: ethyl cellulose 1.5kg, and hydroxypropyl methylcellulose 2.5kg, PEG-60000.8kg, talcum powder 1kg, 95% ethanol 50kg, water 55kg, the back that stirs is crossed 100 mesh sieves and is coating solution A;
Coating solution B preparation technology is: polyacrylic resin 2.5kg, and polyacrylic resin 2kg, 95% ethanol 80kg, water 20kg, talcum powder 2kg, triethyl citrate 1.5kg, methyl-silicone oil 20ml, the back that stirs is crossed 100 mesh sieves and is coating solution B.
The solid particle that makes is crossed the packing of weighing behind 20 eye mesh screens to get product.
The back total acid content is 60.5% after testing, moisture≤8%.
Embodiment 3
20kg lactic acid, 15kg fumaric acid, 15kg citric acid, 10kg formic acid, 5kg propionic acid, 7kg malic acid are mixed stirring, then the liquid that mixes is sprayed in the 28kg carrier silica, fully mix, sneak into synergist origanum oil 2kg then.
Mixed solid microparticle is added efficient fluidized-bed coating machine, under fluidized state, spray into compound coating solution A of 30kg ethyl cellulose and hydroxypropyl methylcellulose and 70kg enteric solubility polyacrylic resin coating solution B successively and wrap and granulated.
Wherein, coating solution A preparation technology is: ethyl cellulose 1.0kg, and hydroxypropyl methylcellulose 2.5kg, PEG-60001kg, talcum powder 1kg, 95% ethanol 50kg, water 35kg, the back that stirs is crossed 100 mesh sieves and is coating solution A; Coating solution B preparation technology is: polyacrylic resin 3kg, and polyacrylic resin 1.5kg, 95% ethanol 70kg, water 13kg, talcum powder 2kg, triethyl citrate 0.5kg, methyl-silicone oil 10ml, the back that stirs is crossed 100 mesh sieves and is coating solution B.
The solid particle that makes is crossed the packing of weighing behind 20 eye mesh screens to get product.The back total acid content is 62.9% after testing, moisture≤8%.
Embodiment 4
The bag of embodiment 1-3 preparation is mixed respectively with sodium bicarbonate powder 5g by acidulant 5g, be contained in the vacuum bag, vacuum packaging, room temperature was placed 48 hours, found that bag phenomenon that do not rise.Illustrate that the bag tegillum is tight.
Embodiment 5
Investigate bag of the present invention by the effect of acidulant in animal produces.
Choose 72 of 21 age in days weanling pigs, be not divided into 3 groups at random by body weight, sex, nest, be respectively: control group (not adding acidulant), test one group and (add 0.2% commercial acidulant, Anhui Tiger Biotechnology Co., Ltd., acidulant II type), test two groups (add bag that 0.2% embodiment 1 makes by acidulant).Relatively acidulant uses in 4 weeks weanling pig growth promotion and anti diar rhea effect.Result of the test is as follows:
Table 1 bag is by the influence of acidulant consumption to weanling pig production performance and diarrhoea situation
| Index | Control group | Plain edition | Bag is by type |
| Initial weight (kg) | 5.3 | 5.3 | 5.3 |
| End heavy (kg) | 13.8 | 14.2 | 14.5 |
| Feed intake | 466 | 492 | 509 |
| Daily gain | 304 | 318 | 329 |
| Feedstuff-meat ratio | 1.53 | 1.55 | 1.55 |
| A diarrhoea number of times | 68 | 42 | 31 |
| Diarrhea rate | 10.1 | 6.3 | 4.6 |
As seen from the above table, this bag of interpolation 0.2% has been significantly improved the feed intake and the daily gain in 0～4 week by the acidulant product in 21 age in days weanling pig daily rations, reduced diarrhea rate, and its effect is better than common acidulant.Therefore in the weanling pig daily ration, add 0.2% bag and can significantly be improved the production performance of animal by acidulant.
Claims (10)
1. a bag is comprised the bag tegillum on acidulant solid microparticle and acidulant solid microparticle surface by acidulant, and described acidulant solid microparticle comprises the component of following parts by weight: lactic acid: 20～30 parts; Fumaric acid: 5～15 parts; Citric acid: 10～15 parts; Malic acid: 5～10 parts; Formic acid: 5～10 parts; Propionic acid: 5～10 parts; Silica: 25～30 parts; 2～3 parts of synergist.
2. bag as claimed in claim 1 is by acidulant, it is characterized in that, described bag tegillum comprises ethyl cellulose and hydroxypropyl methylcellulose composite bed, and the quality of described ethyl cellulose and the compound coatings of hydroxypropyl methylcellulose is 2%～4% of an acidulant solid microparticle quality.。
3. bag as claimed in claim 2 is by acidulant, it is characterized in that, the compound coatings of described ethyl cellulose and hydroxypropyl methylcellulose comprises ethyl cellulose and hydroxypropyl methylcellulose, and wherein the weight ratio of ethyl cellulose and hydroxypropyl methylcellulose is 1: 1～2.5.
As claim 2 or 3 described bags by acidulant, it is characterized in that described bag tegillum outside described ethyl cellulose and hydroxypropyl methylcellulose composite bed, also comprises enteric solubility polyacrylic resin layer; Described enteric solubility polyacrylic resin coatings comprises the enteric solubility polyacrylic resin, and the quality of this coatings is 2%～3% of an acidulant solid microparticle quality.
As claim 2 or 4 described bags by acidulant, it is characterized in that described enteric solubility polyacrylic resin coatings and described ethyl cellulose and the compound coatings of hydroxypropyl methylcellulose also comprise following one or more dressing additives: caking inhibiter, dispersant, plasticizer and defoamer.
6. bag as claimed in claim 5 be is characterized in that by acidulant the quality of described dressing additive is 10%～50% of its affiliated coatings quality.
7. bag as claimed in claim 1 be is characterized in that by acidulant described synergist is probiotics or origanum oil.
As the arbitrary described bag of claim 1-6 by the preparation method of acidulant, it is characterized in that, comprise the steps:
(1) lactic acid, fumaric acid, citric acid, malic acid, formic acid, propionic acid are mixed stirring, then the liquid that mixes is sprayed in the mixer that carrier silica is housed, fully mix, sneak into synergist then, obtain acidulant solid microparticle;
(2) mixed solid microparticle is added efficient fluidized-bed coating machine, under fluidized state, spray into ethyl cellulose and hydroxypropyl methylcellulose composite slow release framework material coating solution A wraps quilt with atomize, spray into enteric solubility polyacrylic resin coating solution B after having sprayed again, obtain bag of the present invention by acidulant;
Wherein: described coating solution A comprises that ethyl cellulose, hydroxypropyl methylcellulose, solvent and one or more comprise the dressing additive of caking inhibiter, dispersant, plasticizer and defoamer; Wherein the mass ratio of ethyl cellulose, hydroxypropyl methylcellulose, solvent and dressing additive is: 1: 1～2.5: 55～80: 0.8～2.0;
Described coating solution B comprises that enteric solubility polyacrylic resin, solvent and one or more comprise the dressing additive of caking inhibiter, dispersant, plasticizer and defoamer; Wherein the mass ratio of enteric solubility polyacrylic resin, solvent and dressing additive is: 1: 10～35: 0.5～2.0.
9. preparation method as claimed in claim 8 is characterized in that, described solvent is water and/or absolute ethyl alcohol.
10. preparation method as claimed in claim 8 is characterized in that, in step 2) afterwards, comprise that also the bag that makes crossed screen cloth by acidulant, packing.
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| 《中国饲料》 20050105 李浙烽 包被和控释技术在饲料工业中的应用 32-33 1-10 , 第1期 * |
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